CN216900595U - Reagent loading equipment and detecting system - Google Patents

Abstract

The application relates to a reagent loading device and a detection system, wherein the reagent loading device comprises a rack, a delivery pump and a liquid suction device. A plurality of placing positions are arranged in the rack and used for placing reagent barrels; the delivery pump is arranged on the frame; the liquid suction device is arranged in a plurality of modes, one liquid suction device corresponds to one reagent barrel, the liquid suction device comprises a control valve and a liquid suction pipe, the liquid suction pipe is arranged to suck out and convey the reagent in the reagent barrel to the conveying pump under the driving of the conveying pump, and the control valve is used for controlling the connection and disconnection between the liquid suction pipe and the conveying pump. The user can open the control valve of the liquid suction device corresponding to one of the reagent barrels to enable the liquid suction pipe to be communicated with the delivery pump, and close the control valves of the liquid suction devices corresponding to the other standby reagent barrels containing the same kind of reagents to block the liquid suction pipe and the delivery pump. When one barrel of reagent is used up, the other barrel can be directly started, the reagent adding device does not need to be stopped, the detection interruption is avoided, and the detection efficiency is greatly improved.

Description

Reagent loading equipment and detecting system

Technical Field

The utility model relates to the technical field of medical instruments, in particular to reagent loading equipment and a detection system.

Background

In the field of in vitro diagnosis, reagents are used in some instruments to detect samples to be detected. The reagent has the characteristics of high price, easy pollution, easy volatilization and the like, and is mostly contained in a reagent barrel with small capacity. Therefore, the conventional reagent loading device is often exposed to the situation that the reagent in the reagent barrel is exhausted during the use process, and the reagent barrel needs to be replaced in time to replenish the reagent.

However, the conventional reagent loading apparatus requires a shutdown operation when changing the reagent, resulting in interruption of reagent loading, which in turn affects detection efficiency.

SUMMERY OF THE UTILITY MODEL

In view of the above, it is necessary to provide a reagent loading apparatus and a detection system.

A reagent loading apparatus, comprising:

the reagent barrel placing device comprises a rack, wherein a plurality of placing positions are arranged in the rack and used for placing reagent barrels;

the conveying pump is arranged on the rack;

the liquid absorbing device is arranged in a plurality of modes, one liquid absorbing device corresponds to one reagent barrel, the liquid absorbing device comprises a control valve and a liquid absorbing pipe, the liquid absorbing pipe is arranged to be capable of absorbing the reagent in the reagent barrel and conveying the reagent to the conveying pump under the driving of the conveying pump, and the control valve is used for controlling the connection and disconnection between the liquid absorbing pipe and the conveying pump.

Above-mentioned reagent loading equipment, the user can place a plurality of reagent buckets that fill with reagent in advance on the position of placing of frame, and every reagent bucket corresponds a pipetting device. For example, a user may choose to place multiple reagent vats containing the same type of reagent for use. When the reagent barrel is used, the control valve of the liquid suction device corresponding to one of the reagent barrels can be opened to enable the liquid suction pipe to be communicated with the delivery pump, and the control valves of the liquid suction devices corresponding to the other standby reagent barrels containing the same kind of reagents are closed to block the liquid suction pipe and the delivery pump. When the reagent in the reagent barrel communicated with the delivery pump is insufficient, the control valve of the liquid suction device corresponding to the reagent barrel is closed, so that the liquid suction pipe is disconnected from the delivery pump, and the control valve corresponding to the other reagent barrel is opened to ensure the normal supply of the reagent. In short, when one of the barrels of reagents is used up, the other barrel of reagent can be directly started, the reagent adding device does not need to be stopped, the detection interruption is avoided, and the detection efficiency is greatly improved.

In one embodiment, the reagent loading apparatus further comprises a sensor for detecting the remaining amount of the reagent in the reagent barrel, wherein the sensor can adjust the control valve according to the remaining amount of the reagent to control the on-off between the pipette and the transfer pump. Through setting up the sensor, can in time learn the reagent surplus in the reagent bucket of supplying reagent at present, when detecting that reagent is not enough, the sensor alright in time close the control valve of the imbibition device that this reagent bucket corresponds to open the control valve of the imbibition device that reagent bucket that holds another reagent corresponds, and then realize the automatic switch-over of reagent bucket, guarantee the continuous supply of reagent. In addition, when the reagent of reagent bucket is not enough, its control valve of imbibition device that corresponds closes in time, can prevent to produce the bubble because the reagent of carrying is too few, avoids the testing result to receive the influence.

In one embodiment, the pipetting device further comprises a manifold joint through which a plurality of the pipettes are connected with the delivery pump.

In one embodiment, the multi-way pipe joint is a Y-shaped three-way joint, and two of the pipette tubes corresponding to every two reagent barrels are connected with the delivery pump through one Y-shaped three-way joint.

In one embodiment, the pipetting device further comprises a lifting assembly arranged on the rack, and the lifting assembly is used for driving the pipette to lift relative to the rack so as to enter and exit the reagent barrel.

In one embodiment, the lifting assembly comprises a support, a clamping member, a guide shaft, a guide sleeve and a handle connected to the pipette, the support is arranged in the rack, the clamping member is fixed to the support, the guide shaft is connected to the support, the guide shaft is arranged along the height direction of the rack, the guide sleeve is slidably sleeved on the guide shaft and connected to the handle, the handle is arranged to be capable of driving the guide sleeve to slide relative to the guide shaft under the action of an external force, and the guide sleeve is in clamping fit with the clamping member until the pipette is driven by the handle to move out of the reagent barrel. When the user operating handle drives the pipette to move out of the reagent barrel, the guide sleeve connected with the handle is just fixed with the clamping piece in a clamping manner, the user operating handle is not needed at the moment, the pipette connected with the handle can hover above the reagent barrel, and a user can conveniently replace the reagent barrel below the pipette.

In one embodiment, the screens piece is the bulb plunger, the screens groove has been seted up to the global outside of uide bushing, the uide bushing is set up to be able to be relative when the guiding axle slides the extrusion screens piece, until the screens piece at least part stretch into in the screens groove with the uide bushing joint.

In one embodiment, a linear bearing is fixedly connected in the guide sleeve, and the guide sleeve is sleeved on the guide shaft through the linear bearing. The arrangement of the linear bearing can ensure that the guide sleeve is more accurate and smooth when sliding relative to the guide shaft, namely the movement precision of the handle and the pipette which are connected with the guide sleeve is improved.

In one embodiment, the lifting assembly further comprises a fixed block, the fixed block is arranged on the support, and the fixed block is fixedly connected with the clamping piece.

In one embodiment, a linear bearing is fixedly connected in the guide sleeve, and the guide sleeve is sleeved on the guide shaft through the linear bearing;

and/or the rack is also provided with a limiting sliding groove, and the handle is inserted in the limiting sliding groove to be in limiting fit with the limiting sliding groove. The setting of spacing spout can be at the process of user operation handle, makes the motion of handle more steady accurate.

A test system comprising a reagent loading apparatus as described in any of the above embodiments.

Drawings

In order to more clearly illustrate the technical solutions in the embodiments or the conventional technologies of the present application, the drawings used in the descriptions of the embodiments or the conventional technologies will be briefly introduced below, it is obvious that the drawings in the following descriptions are only some embodiments of the present application, and for those skilled in the art, other drawings can be obtained according to the drawings without creative efforts.

FIG. 1 is a perspective view of a reagent loading apparatus according to an embodiment of the present invention;

FIG. 2 is an exploded view of a reagent loading apparatus provided in accordance with an embodiment of the present invention;

FIG. 3 is a schematic diagram of the connection of a reagent cartridge to a transfer pump according to one embodiment of the present invention;

fig. 4 is a structural perspective view of a pipette and a lift assembly provided in one embodiment of the utility model;

fig. 5 is a partial cross-sectional view of a lift assembly provided in accordance with one embodiment of the present invention.

Reference numerals are as follows:

10. a reagent loading device; 20. a reagent barrel; 100. a frame; 101. placing bits; 102. a limiting chute; 200. a delivery pump; 300. a liquid suction device; 310. a pipette; 311. a filter; 320. a control valve; 330. a multi-way pipe joint; 340. a lifting assembly; 341. a support; 342. a clamping piece; 343. a guide shaft; 344. a guide sleeve; 3441. a clamping groove; 345. a handle; 346. a linear bearing; 347. a fixed block; 400. a sensor.

Detailed Description

In order to make the aforementioned objects, features and advantages of the present invention comprehensible, embodiments accompanied with figures are described in detail below. In the following description, numerous specific details are set forth in order to provide a thorough understanding of the present invention. This invention may, however, be embodied in many different forms and should not be construed as limited to the embodiments set forth herein.

Referring to fig. 1, fig. 2 and fig. 3, the present application provides a reagent loading apparatus 10, which includes a rack 100, a transfer pump 200 disposed in the rack 100, and a pipetting device 300. A plurality of placing positions 101 are arranged in the rack 100, and the placing positions 101 can be used for placing the reagent buckets 20. The pipetting device 300 is provided in a plurality, one pipetting device 300 corresponds to one reagent barrel 20, the pipetting device 300 comprises a control valve 320 and a pipette 310, the pipette 310 is provided to suck out and convey the reagent in the reagent barrel 20 to the transfer pump 200 under the driving of the transfer pump 200, and the control valve 320 is used for controlling the connection and disconnection between the pipette 310 and the transfer pump 200. It is considered that only one reagent barrel 20 can be placed in one placing position 101, and the number of placing positions 101 is the same as the number of reagent barrels 20. It can be understood that a plurality of reagent buckets 20 containing the same type of reagent can be placed on the plurality of placing positions 101, and a plurality of reagent buckets 20 containing different types of reagents can also be placed on the plurality of placing positions 101. In other words, the specific number of the placing positions 101 in the rack 100, the placing number of the reagent buckets 20, the types of the reagents in the reagent buckets 20, and the like can be flexibly adjusted by the user according to the actual situation. Wherein the control valve 320 may be a two-way valve.

In the reagent loading apparatus 10, a user may pre-place a plurality of reagent buckets 20 filled with reagents on the placement positions 101 of the rack 100, wherein each reagent bucket 20 corresponds to one pipetting device 300. For example, a user may choose to place multiple reagent vats 20 containing the same type of reagent for use. In use, the control valve 320 of the pipetting device 300 corresponding to one of the reagent buckets 20 can be opened to communicate the pipette 310 with the transfer pump 200, and the control valves 320 of the pipetting devices 300 corresponding to the other spare reagent buckets 20 containing the same kind of reagent can be closed to block the pipette 310 from the transfer pump 200. When the reagent in the reagent barrel 20 communicated with the transfer pump 200 is insufficient, the pipette 310 can be disconnected from the transfer pump 200 by closing the control valve 320 of the pipetting device 300 corresponding to the reagent barrel 20, and the control valve 320 corresponding to another reagent barrel 20 can be opened to ensure the normal supply of the reagent.

In short, when one barrel of reagent is used up, the other barrel can be directly started, the reagent adding device does not need to stop, the interruption of detection is avoided, and the detection efficiency is greatly improved. For example, in the embodiment shown in fig. 1, six placement locations are provided in the rack 100, and six reagent vats 20 can be placed at the same time. Wherein, two reagent buckets 20 are filled with A type reagent, two reagent buckets 20 are filled with B type reagent, and two reagent buckets 20 are filled with C type reagent. When the pipette 310 corresponding to one reagent bucket 20 containing type A reagent is connected to the transfer pump 200, the pipette 310 corresponding to the other reagent bucket 20 containing type A reagent is disconnected from the transfer pump 200. When the type A reagent in one reagent barrel 20 containing the type A reagent is insufficient, the other reagent barrel 20 containing the type A reagent can be directly started. For the specific use process of the two reagent barrels 20 containing the type B reagent and the two reagent barrels 20 containing the type C reagent, reference may be made to the use process of the two reagent barrels 20 containing the type a reagent, which is not described herein again.

Referring to fig. 3, in some embodiments, the pipetting device 300 further includes a manifold 330, and the plurality of pipettes 310 are connected to the transfer pump 200 through the manifold 330. For example, in the embodiment shown in fig. 3, the multi-way joint 330 is a Y-type three-way joint, two reagent buckets 20 containing the same reagent are provided, and two pipettes 310 corresponding to the two reagent buckets 20 can be connected to the transfer pump 200 through one multi-way joint 330. In some embodiments, the transfer pump 200 is fixedly attached within the frame 100. And the transfer pump 200 can be provided in plurality, and one transfer pump 200 can be connected with two pipettes 310 corresponding to two reagent buckets 20 of two reagents through one multi-way union 330.

Referring to fig. 4, in some embodiments, the pipetting device 300 further includes a lifting assembly 340 disposed on the rack 100, wherein the lifting assembly 340 is configured to lift the pipette 310 relative to the rack 100 to access the reagent tank 20.

Specifically, as shown in fig. 4 and 5, in some embodiments, the lifting assembly 340 includes a bracket 341, a detent 342, a guide shaft 343, a guide sleeve 344, and a handle 345. The handle 345 is connected with the pipette 310 and used for driving the pipette 310, the bracket 341 is arranged in the rack 100, the blocking part 342 is fixed with the bracket 341, the guide shaft 343 is connected with the bracket 341, the guide shaft 343 is arranged along the height direction of the rack 100, the guide sleeve 344 is slidably sleeved on the guide shaft 343, the guide sleeve 344 is connected with the handle 345, the handle 345 is arranged to be capable of driving the guide sleeve 344 to slide relative to the guide shaft 343 under the action of external force, and the guide sleeve 344 is in blocking fit with the blocking part 342 until the pipette 310 is moved out of the reagent barrel 20 under the driving of the handle 345. When the user operates the handle 345 to move the pipette 310 out of the reagent barrel 20, the guide sleeve 344 connected with the handle 345 is just clamped and fixed with the clamping piece 342, and at this time, the pipette 310 connected with the handle 345 can be suspended above the reagent barrel 20 without operating the handle 345 by the user, so that the user can conveniently replace the reagent barrel 20 below the pipette 310.

Further, in the embodiment shown in fig. 5, the lifting assembly 340 further includes a fixing block 347, the fixing block 347 is disposed on the bracket 341, and the fixing block 347 is fixedly connected to the locking member 342. The blocking member 342 is a ball plunger, the blocking groove 3441 is formed on the outer peripheral surface of the guide sleeve 344, and the guide sleeve 344 is configured to be capable of pressing the blocking member 342 when sliding relative to the guide shaft 343 until the blocking member 342 at least partially extends into the blocking groove 3441 to be blocked with the guide sleeve 344. During specific operation, a user can operate the handle 345 to drive the guide sleeve 344 to slide upwards along the axial direction of the guide shaft 343, the blocking piece 342 is extruded and deformed by the guide sleeve 344, and when the blocking groove 3441 on the outer circumferential surface of the guide sleeve 344 is opposite to the blocking piece 342, part of the structure of the blocking piece 342 rebounds to extend into the blocking groove 3441, so that the blocking piece 342 and the guide sleeve 344 are blocked and fixed. The pipette 310 is now outside the reagent cartridge 20 and the user can replace the reagent cartridge 20. After the user replaces the reagent barrel 20, the handle 345 can be further operated to drive the guide sleeve 344 to slide downwards along the guide shaft 343, and the blocking member 342 can be pushed by the guide sleeve 344 to be separated from the blocking groove 3441, so as to be separated from the guide sleeve 344.

Further, as shown in fig. 5, in some embodiments, a linear bearing 346 is further fixedly connected in the guide sleeve 344, and the guide sleeve 344 is sleeved on the guide shaft 343 via the linear bearing 346. The linear bearing 346 is provided to make the guide sleeve 344 slide with respect to the guide shaft 343 more accurate and smooth, i.e., to improve the accuracy of movement of the handle 345 and the pipette 310 connected to the guide sleeve 344.

Referring to fig. 4, in some embodiments, the reagent loading apparatus 10 further includes a sensor 400 disposed on the bracket 341, the sensor 400 can be used for detecting the remaining amount of the reagent in the reagent barrel 20, and the sensor 400 can adjust the control valve 320 according to the remaining amount of the reagent to control the connection/disconnection between the pipette 310 and the transfer pump 200. Through setting up sensor 400, can in time learn the reagent surplus in the reagent bucket 20 that is supplying reagent at present, when detecting that reagent is not enough, sensor 400 alright in time close the control valve 320 of the imbibition device 300 that this reagent bucket 20 corresponds to open the control valve 320 of the imbibition device 300 that another reagent bucket 20 that contains reagent corresponds, and then realize the automatic switch-over of reagent bucket 20, guarantee the continuous supply of reagent. In addition, when the reagent in the reagent barrel 20 is insufficient, the corresponding control valve 320 of the liquid suction device 300 is closed in time, so that bubbles generated due to too little reagent can be prevented, and the detection result is prevented from being influenced.

Referring to fig. 1 and fig. 2, in some embodiments, the rack 100 is further provided with a limiting sliding groove 102, the limiting sliding groove 102 is in a strip shape and extends along the height direction of the rack 100, and the handle 345 is inserted into the limiting sliding groove 102 to be in limiting fit with the limiting sliding groove 102, that is, the handle 345 penetrates through the limiting sliding groove 102 and is disposed on the rack 100. When the handle 345 drives the pipette 310 to move up and down relative to the rack 100 under the action of an external force, the rack 100 is in limit fit with the handle 345 through the groove wall of the limit chute 102 to limit the moving direction of the handle 345. The arrangement of the limit chute 102 can make the movement of the handle 345 more stable and accurate during the operation of the handle 345 by the user.

Referring to fig. 4, in some embodiments, the reagent loading apparatus 10 further includes a filter 311 for filtering the reagent, the filter 311 being connected to the pipette 310 for extending into an end of the reagent barrel 20.

The present application also provides a detection system comprising a reagent loading apparatus as described in any of the above embodiments. The type of the detection system is not limited, and may be, for example, a biochemical detection device, an immunoassay device, a biochemical immunoassay cascade detection device, or the like, which requires reagent loading. The immunoassay device may be, for example, an electrochemiluminescence analyzer.

In the present invention, unless otherwise expressly stated or limited, the terms "mounted," "connected," "secured," and the like are to be construed broadly and can, for example, be fixedly connected, detachably connected, or integrally formed; can be mechanically or electrically connected; they may be directly connected or indirectly connected through intervening media, or they may be connected internally or in any other suitable relationship, unless expressly stated otherwise. The specific meanings of the above terms in the present invention can be understood by those skilled in the art according to specific situations.

In the present invention, unless otherwise expressly stated or limited, the first feature "on" or "under" the second feature may be directly contacting the first and second features or indirectly contacting the first and second features through an intermediate. Also, a first feature "on," "over," and "above" a second feature may be directly or diagonally above the second feature, or may simply indicate that the first feature is at a higher level than the second feature. A first feature being "under," "below," and "beneath" a second feature may be directly under or obliquely under the first feature, or may simply mean that the first feature is at a lesser elevation than the second feature.

In the description of the present invention, the terms "first" and "second" are used for descriptive purposes only and are not to be construed as indicating or implying relative importance or implying any number of technical features indicated. Thus, a feature defined as "first" or "second" may explicitly or implicitly include at least one such feature. In the description of the present invention, "a plurality" means at least two, e.g., two, three, etc., unless specifically limited otherwise.

In the description of the present invention, when an element is referred to as being "on," "disposed on" or "secured to" another element, it can be directly on the other element or intervening elements may also be present. When an element is referred to as being "connected" to another element, it can be directly connected to the other element or intervening elements may also be present. As used herein, the terms "vertical," "horizontal," "upper," "lower," "left," "right," and the like are for purposes of illustration only and do not denote a single embodiment.

In the description of the present invention, it is to be understood that the terms "central," "longitudinal," "lateral," "length," "width," "thickness," "upper," "lower," "front," "rear," "left," "right," "vertical," "horizontal," "top," "bottom," "inner," "outer," "clockwise," "counterclockwise," "axial," "radial," "circumferential," and the like are used in the orientations and positional relationships indicated in the drawings for convenience in describing the utility model and to simplify the description, and are not intended to indicate or imply that the referenced device or element must have a particular orientation, be constructed and operated in a particular orientation, and are not to be considered limiting of the utility model.

Furthermore, the terms "first", "second" and "first" are used for descriptive purposes only and are not to be construed as indicating or implying relative importance or implicitly indicating the number of technical features indicated. Thus, a feature defined as "first" or "second" may explicitly or implicitly include at least one of the feature. In the description of the present invention, "a plurality" means at least two, e.g., two, three, etc., unless specifically limited otherwise.

The technical features of the embodiments described above may be arbitrarily combined, and for the sake of brevity, all possible combinations of the technical features in the embodiments described above are not described, but should be considered as being within the scope of the present specification as long as there is no contradiction between the combinations of the technical features.

The above-mentioned embodiments only express several embodiments of the present invention, and the description thereof is more specific and detailed, but not construed as limiting the scope of the utility model. It should be noted that, for a person skilled in the art, several variations and modifications can be made without departing from the inventive concept, which falls within the scope of the present invention. Therefore, the protection scope of the present patent shall be subject to the appended claims.

In the description herein, references to the description of "an embodiment," "other embodiments," etc., mean that a particular feature, structure, material, or characteristic described in connection with the embodiment or example is included in at least one embodiment or example of the utility model. In this specification, a schematic description of the above terminology may not necessarily refer to the same embodiment or example. Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this application belongs. The terminology used herein in the description of the present application is for the purpose of describing particular embodiments only and is not intended to be limiting of the application.

Claims (10)

1. A reagent loading apparatus, comprising:

the reagent barrel placing device comprises a rack, wherein a plurality of placing positions are arranged in the rack and used for placing reagent barrels;

the conveying pump is arranged on the rack;

the liquid absorbing device is arranged in a plurality of modes, one liquid absorbing device corresponds to one reagent barrel, the liquid absorbing device comprises a control valve and a liquid absorbing pipe, the liquid absorbing pipe is arranged to be capable of absorbing the reagent in the reagent barrel and conveying the reagent to the conveying pump under the driving of the conveying pump, and the control valve is used for controlling the connection and disconnection between the liquid absorbing pipe and the conveying pump.

2. The reagent loading apparatus of claim 1, further comprising a sensor for detecting a reagent remaining amount in the reagent bucket, the sensor being capable of adjusting the control valve to control the on-off between the pipette and the transfer pump according to the reagent remaining amount.

3. The reagent loading apparatus of claim 1, wherein the pipetting device further comprises a manifold joint through which a plurality of the pipettes are connected with the transfer pump.

4. The reagent loading apparatus of claim 3, wherein the multi-way joint is a Y-shaped three-way joint, and two pipettes corresponding to every two reagent buckets are connected with the delivery pump through one Y-shaped three-way joint.

5. The reagent loading apparatus of claim 1, wherein the pipetting device further comprises a lifting assembly disposed on the rack for moving the pipettes up and down relative to the rack for accessing the reagent bucket.

6. The reagent loading device of claim 5, wherein the lifting assembly comprises a support, a locking member, a guide shaft, a guide sleeve and a handle connected to the pipette, the support is disposed in the rack, the locking member is fixed to the support, the guide shaft is connected to the support, the guide shaft is disposed along a height direction of the rack, the guide sleeve is slidably sleeved on the guide shaft, the guide sleeve is connected to the handle, and the handle is configured to drive the guide sleeve to slide relative to the guide shaft under an external force until the pipette is moved out of the reagent barrel under the driving of the handle, and the guide sleeve is in snap fit with the locking member.

7. The reagent loading device of claim 6, wherein the blocking member is a ball plunger, a blocking groove is formed in the outer peripheral surface of the guide sleeve, the guide sleeve is arranged to be capable of extruding the blocking member when sliding relative to the guide shaft until the blocking member at least partially extends into the blocking groove to be clamped with the guide sleeve.

8. The reagent loading apparatus of claim 6, wherein the lifting assembly further comprises a fixed block, the fixed block is disposed on the bracket, and the fixed block is fixedly connected to the retaining member.

9. The reagent loading apparatus of claim 6, wherein a linear bearing is fixedly connected in the guide sleeve, and the guide sleeve is sleeved on the guide shaft through the linear bearing;

and/or the rack is also provided with a limiting sliding groove, and the handle is inserted in the limiting sliding groove to be in limiting fit with the limiting sliding groove.

10. A test system comprising a reagent loading apparatus according to any one of claims 1 to 9.

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