CN216870583U

CN216870583U - Sample analysis apparatus

Info

Publication number: CN216870583U
Application number: CN202122982193.3U
Authority: CN
Inventors: 程蛟; 李江波
Original assignee: Shenzhen Mindray Bio Medical Electronics Co Ltd
Current assignee: Shenzhen Mindray Bio Medical Electronics Co Ltd
Priority date: 2021-11-30
Filing date: 2021-11-30
Publication date: 2022-07-01
Anticipated expiration: 2031-11-30

Abstract

The utility model discloses a sample analysis device, comprising: the sample bearing mechanism is provided with at least one sample position, and the sample position is used for placing a sample container; the reaction mechanism comprises at least one placing position, and the placing position is used for placing the reaction cup and incubating reaction liquid in the reaction cup; a sample dispensing mechanism including a moving member for driving the sample needle to move between a sample position and a placing position to suck the sample at the sample position by the sample needle and discharge the sample at the placing position, and a measuring member for measuring a reaction liquid to be measured; liquid way supporting mechanism includes water tank, water pump, control valve and the syringe that connects gradually through the connecting pipe, and the connecting pipe between syringe and the sample needle is first connecting tube, and the length of first connecting tube is 1400mm to 1600mm, is 0.92mm to 1.12 mm. The utility model can reduce the fluctuation of the liquid during flowing and ensure the sampling precision of the sample needle.

Description

Sample analysis apparatus

Technical Field

The utility model relates to the technical field of medical instruments, in particular to sample analysis equipment.

Background

In the sample analysis device, the sample needle is connected with the injector through the connecting pipe, the connecting pipe is filled with a working medium such as water, the working medium flows along with the movement of the piston of the injector to form negative pressure or positive pressure in the connecting pipe, so that the suction and the discharge of the sample to the sample are realized, however, the working medium can generate fluctuation along with the frequent movement of the piston when flowing in the pipe, and the sampling precision of the sample needle is influenced.

SUMMERY OF THE UTILITY MODEL

The present invention is directed to solving at least one of the problems of the prior art. Therefore, the utility model provides a sample analysis device which can buffer working liquid and ensure the sampling precision of a sample needle.

A sample analysis apparatus according to an embodiment of the present invention includes:

the sample bearing mechanism is provided with at least one sample position, the sample position is used for placing a sample container, and the sample container is used for accommodating a sample;

the reaction mechanism comprises at least one placing position, the placing position is used for placing a reaction cup and incubating reaction liquid in the reaction cup, and the reaction liquid is prepared by the sample;

a sample dispensing mechanism including a moving member and a sample needle provided on the moving member, the moving member for driving the sample needle to move between the sample position and the placement position to aspirate a sample at the sample position through the sample needle and discharge the sample at the placement position;

a measuring unit for measuring a reaction solution to be measured;

the liquid path supporting mechanism comprises a water tank, a water pump, a control valve and a syringe, wherein the water tank, the water pump, the control valve, the syringe and the sample needle are sequentially connected through connecting pipes, the connecting pipe between the syringe and the sample needle is a first connecting pipe, the length of the first connecting pipe is 1400 mm-1600 mm, and the inner diameter of the first connecting pipe is 0.92 mm-1.12 mm.

The sample analysis device provided by the embodiment of the utility model has at least the following beneficial effects:

in this embodiment, first connecting pipe has relatively great pipe length and internal diameter for working liquid can obtain the buffering when flowing, thereby can reduce the fluctuation when liquid flows to a certain extent, guarantees the sampling precision of sample needle.

In other embodiments of the present invention, the fluid path support mechanism further includes at least one adaptor, a plurality of first connecting tubes are disposed between the syringe and the sample needle, and adjacent first connecting tubes are connected by the adaptor.

In other embodiments of the present invention, the fluid path support mechanism further includes a pressure sensor connected between the sample needle and the syringe through the first connection tube.

In other embodiments of the present invention, the connection pipe between the control valve and the syringe is a second connection pipe having a length of 400mm to 600 mm.

In other embodiments of the present invention, the second connection pipe has an inner diameter of 1.3mm to 1.7 mm.

In other embodiments of the present invention, the fluid path support mechanism further includes at least one adaptor, a plurality of second connection pipes are disposed between the control valve and the syringe, and adjacent second connection pipes are connected by the adaptor.

In other embodiments of the present invention, the fluid path support mechanism further includes a pressure sensor connected between the control valve and the syringe through the second connection pipe.

In other embodiments of the present invention, the sample needle comprises a first body portion and a first needle tip portion, the first needle tip portion is connected to the first body portion and has a constant outer diameter, wherein the outer diameter of the first needle tip portion is less than or equal to 0.6 mm;

the sample analysis apparatus further includes an ultrasonic cleaning mechanism for non-contact cleaning of the sample needle after discharge of a sample.

In other embodiments of the present invention, the sample analysis apparatus further includes a reagent dispensing mechanism including a reagent needle including a second body portion and a second tip portion connected to the second body portion and having a constant inner diameter, and a ratio of a length of the second tip portion to the inner diameter is less than or equal to 10.

In other embodiments of the present invention, the sample analyzer further includes a box and a pipe holder, the sample loading mechanism, the reaction mechanism, the sample dispensing mechanism, the measuring unit, the liquid path supporting mechanism, and the pipe holder are all connected to the box, the pipe holder includes a first connecting plate and a fixing member, and at least a portion of the first connecting pipe is connected to the first connecting plate through the fixing member, so that the first connecting pipe has at least one bending portion.

In other embodiments of the present invention, the first connecting tube includes a first vertical tube section and a second vertical tube section, the second vertical tube section is connected to the first connecting plate through the fixing member, the first vertical tube section is connected to the sample needle and can move synchronously with the sample needle, and the first vertical tube section and the second vertical tube section are connected through the bending portion.

In other embodiments of the present invention, the pipe support further comprises a second connecting plate connected to the first connecting plate and having an included angle α, wherein 0 < α < 180 °, a portion of the first connecting pipe is connected to the second connecting plate by the fixing member.

In other embodiments of the present invention, the box body includes a frame and a mounting plate, the mounting plate is connected to the frame, a mounting space is formed below the mounting plate, and the duct bracket is located in the mounting space and connected to a lower side of the mounting plate.

Additional aspects and advantages of the utility model will be set forth in part in the description which follows and, in part, will be obvious from the description, or may be learned by practice of the utility model.

Drawings

The utility model is further described with reference to the following figures and examples, in which:

FIG. 1 is a schematic plan view of a sample analysis apparatus of the present invention;

FIG. 2 is a schematic diagram of a fluid path support mechanism of the sample analysis device of FIG. 1;

FIG. 3 is a schematic diagram of a fluid circuit support mechanism in another embodiment of the present invention;

FIG. 4 is a schematic diagram of a fluid circuit support mechanism in another embodiment of the present invention;

FIG. 5 is a cross-sectional view of a sample needle of the sample analysis device of FIG. 1;

FIG. 6 is a cross-sectional view of a reagent needle of the sample analysis device of FIG. 1;

FIG. 7 is a front view of the sample analysis device of FIG. 1 with the housing coupled to the tube holder;

FIG. 8 is a perspective view of FIG. 7;

FIG. 9 is a perspective view of the conduit bracket of FIG. 7;

fig. 10 is a perspective view illustrating the pipe bracket of fig. 9 connected to a first connection pipe.

Reference numerals:

sample dispensing mechanism 100, sample needle 110, first body 111, and first tip 112

The liquid path support mechanism 200, the injector 210, the control valve 220, the water tank 240, the water pump 230, the first connecting pipe 250, the first vertical pipe section 251, the second vertical pipe section 252, the bent portion 253, the first horizontal pipe section 254, the second horizontal pipe section 255, the third horizontal pipe section 256, the second connecting pipe 260, the pressure sensor 270, the pipe joint 280, and the like

A sample support mechanism 300;

a reaction mechanism 400;

a measuring unit 500;

a reagent dispensing mechanism 600, a second body portion 611, and a second needle tip portion 612;

a reagent carrying mechanism 700;

a box 800, a frame 810, a mounting plate 820;

pipe bracket 900, first connecting plate 910, second connecting plate 920, mounting 930, third connecting plate 940.

Detailed Description

Reference will now be made in detail to embodiments of the present invention, examples of which are illustrated in the accompanying drawings, wherein like or similar reference numerals refer to the same or similar elements or elements having the same or similar function throughout. The embodiments described below with reference to the accompanying drawings are illustrative only for the purpose of explaining the present invention, and are not to be construed as limiting the present invention.

In the description of the present invention, it should be understood that the orientation or positional relationship referred to in the description of the orientation, such as the upper, lower, front, rear, left, right, etc., is based on the orientation or positional relationship shown in the drawings, and is only for convenience of description and simplification of description, and does not indicate or imply that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, and thus, should not be construed as limiting the present invention.

In the description of the present invention, the meaning of a plurality is one or more, the meaning of a plurality is two or more, and the above, below, exceeding, etc. are understood as excluding the present numbers, and the above, below, within, etc. are understood as including the present numbers. If the first and second are described for the purpose of distinguishing technical features, they are not to be understood as indicating or implying relative importance or implicitly indicating the number of technical features indicated or implicitly indicating the precedence of the technical features indicated.

In the description of the present invention, unless otherwise explicitly limited, terms such as arrangement, installation, connection and the like should be understood in a broad sense, and those skilled in the art can reasonably determine the specific meanings of the above terms in the present invention in combination with the specific contents of the technical solutions.

In the description of the present invention, reference to the description of the terms "one embodiment," "some embodiments," "an illustrative embodiment," "an example," "a specific example," or "some examples," etc., means that a particular feature, structure, material, or characteristic described in connection with the embodiment or example is included in at least one embodiment or example of the present invention. In this specification, the schematic representations of the terms used above do not necessarily refer to the same embodiment or example. Furthermore, the particular features, structures, materials, or characteristics described may be combined in any suitable manner in any one or more embodiments or examples.

Referring to fig. 1, a schematic plan view of a sample analysis apparatus according to an embodiment of the present invention is shown, in which a broken line indicates a rotation locus of a rotating member. The Sample analysis device of the embodiment of the present invention includes a Sample dispensing mechanism 100, a liquid path supporting mechanism 200, a Sample carrying mechanism 300, a reaction mechanism 400, and a measurement component 500, wherein the Sample carrying mechanism 300 is used for carrying a Sample, and may include a Sample Delivery Module (SDM) and a front end rail; in other embodiments, it may also be a rotary sample tray, and the sample tray is provided with at least one sample position for placing a sample container such as a sample tube, and the sample can be dispatched to a corresponding position, such as a position for the sample dispensing mechanism 100 to suck the sample, by the rotation of the sample tray.

The reaction mechanism 400 is used for bearing a reaction container, which may be a rotary reaction tray, and the reaction tray is provided with at least one placing position for placing a reaction cup, so as to incubate the reaction solution in the reaction cup.

The sample dispensing mechanism 100 includes a moving member and a sample needle 110, the sample needle 110 is movable between a sample position and a placement position by being driven by the moving member, so as to suck a sample at the sample position and discharge the sample at the placement position, and the moving member may be a driving member movable in a two-dimensional or three-dimensional space, such as a linear moving device based on motor-screw or motor-timing belt driving.

The measuring unit 500 may be a photometric unit for performing photometric measurement on the reaction solution after completion of incubation to obtain reaction data of the sample. For example, the photometric device may detect the light emission intensity of a reaction solution to be measured, and calculate the concentration of a component to be measured in a sample from a calibration curve.

The liquid path support mechanism 200 is used to provide the sample needle 110 with power for sucking and discharging the sample liquid, and cleaning liquid for cleaning the inner wall of the sample needle 110. Referring to fig. 2, which is a schematic diagram of a fluid circuit supporting mechanism 200, as shown, the fluid circuit supporting mechanism 200 includes a syringe 210, a control valve 220, a water tank 240 and a water pump 230, but in other embodiments, other related components may be included.

As shown in the figure, the sample needle 110, the syringe 210, the control valve 220, and the water pump 230 are connected in sequence with a water tank 240 through connecting pipes, and the water tank 240 is used for storing a working fluid which can be used for flushing the inner wall of the sample needle 110 and can also be used as a power transmission medium to cooperate with the syringe 210 to form positive pressure or negative pressure in the connecting pipes so as to provide power for discharging or sucking samples from the sample needle 110. The water pump 230 is used to drive the working fluid from the water tank 240 to the sample needle 110. The control valve 220 may be an electrically controlled valve having at least two states, open and closed, for controlling the connection and disconnection of the pipe between the syringe 210 and the water pump 230. The syringe 210 is used to provide the motive force for the sample needle 110 to aspirate and discharge the sample and includes a piston and a barrel, the piston being controllably moved in a piston cavity of the barrel by a drive mechanism to change the pressure state within the connecting tube. In use, the control valve 220 is in a closed state, the connection pipeline between the control valve 220 and the sample needle 110 is filled with the working liquid, and the sample needle 110 can suck a sample from the sample container when the piston moves relative to the cylinder body to increase the volume of the piston cavity; the sample needle 110 may discharge a sample into the reaction vessel when the piston moves in reverse relative to the barrel to reduce the volume of the piston cavity. After the sample needle 110 finishes discharging a single sample, the sample needle 110 needs to be cleaned, so as to prevent cross contamination between the sample remaining on the sample needle 110 and the sample to be sampled next time, one of the cleaning links is to clean the inner wall of the sample needle 110, at this time, the control valve 220 is opened, and the working fluid in the water tank 240 can flow along the connecting pipe under the driving of the water pump 230, and is finally discharged from the sample needle 110 to flush the inner wall. After the flushing action is completed, the control valve 220 is closed again, and the next sampling can be performed by the injector 210 by repeating the above actions.

In the sampling process, since the power for sucking and discharging the sample by the sample needle 110 is transmitted through the working fluid in the connection tube, the flow resistance of the working fluid in the connection tube is required, especially the flow resistance in the connection tube between the syringe 210 and the sample needle 110 is in a certain range to ensure the sampling precision of the sample needle 110, for convenience of description, the connection tube between the syringe 210 and the sample needle 110 is referred to as a first connection tube 250, the first connection tube 250 has a length of 1400mm to 1600mm and an inner diameter of 0.92mm to 1.12mm, in this range, the working fluid needs to flow a relatively long distance to reach the sample needle 110, and meanwhile, the larger lumen can also buffer the working fluid in the flow process, so that the fluctuation of the fluid during the flow can be reduced to a certain extent, and the sampling precision of the sample needle 110 can be ensured.

The connection tube between the syringe 210 and the sample needle 110 may be a whole continuous tube as shown in fig. 2, or may be divided into multiple segments, specifically, as shown in fig. 3, a plurality of first connection tubes 250 are included between the syringe 210 and the sample needle 110, and adjacent first connection tubes 250 are connected by an adapter, so that the number and length of the first connection tubes 250 can be adjusted according to actual installation conditions. The adapter may be the pipe joint 280 in fig. 3, and the first connecting pipes 250 have the same pipe diameter and the same or different length.

In some alternative embodiments, referring to fig. 4, the adaptor may also be a functional device such as a pressure sensor 270, that is, the adaptor may perform both a connection function and a pressure detection function. Taking pressure sensor 270 as an example, it may detect the pressure in first connecting tube 250, facilitating corresponding control of fluid circuit support mechanism 200.

It should be noted that the number of the first connection tubes 250 and the adapters is not limited to the number shown in fig. 3 and 4, for example, three or more first connection tubes 250 may be connected between the syringe 210 and the sample needle 110, and different adapters may be used in combination, for example, when there are three or more first connection tubes 250, each first connection tube 250 may be connected to the pressure sensor 270 through the tube joint 280 in sequence. The pressure sensor 270 may be replaced with other sensors or other functional devices.

Referring to fig. 3, for convenience of description, the connection pipe between the control valve 220 and the syringe 210 is referred to as a second connection pipe 260, and in some embodiments of the present invention, the second connection pipe 260 has a length of 400mm to 600mm, and the working fluid has a high flow rate when being pumped from the water pump 230, and the second connection pipe 260 is used to connect the control valve 220 and the syringe 210, on the one hand, and also can provide a certain flow resistance, so as to reduce the flow rate of the working fluid and to achieve buffering of the working fluid to some extent.

Taking fig. 3 as an example, the control valve 220 and the injector 210 may be connected by a plurality of second connection pipes 260, and the second connection pipes 260 may have the same pipe diameter, the same length, or different lengths. Similar to the first connection pipes 250, the adjacent second connection pipes 260 are connected by adapters, so that the number and the length of the second connection pipes 26 can be adjusted according to actual installation conditions. The adaptor may be a pressure sensor 270 shown in the figure, and the pressure sensor 270 is used for detecting the pressure in the second connection pipe 260, so as to facilitate the corresponding control of the fluid path support mechanism 200. Of course, the control valve 220 and the injector 210 may be connected by a whole second connection tube 260.

As an alternative to the above, referring to fig. 4, the adapter may also be a pipe fitting 280. It should be noted that the control valve 220 and the syringe 210 may be connected by three or more second connection pipes 260, and different adapters may be used in combination, for example, when there are three or more second connection pipes 260, each second connection pipe 260 may be connected to the pressure sensor 270 through the pipe joint 280 in sequence.

In some embodiments of the present invention, the inner diameter of the second connection pipe 260 is 1.3mm to 1.7mm, i.e. greater than the inner diameter of the first connection pipe 250, and the fast flowing working fluid can flow into the second connection pipe 260 with a larger lumen first and then flow into the first connection pipe 250, so that the working fluid can be buffered.

In order to suck the sample, the tip portion of the sample needle 110 needs to be frequently contacted with the liquid, and in order to avoid cross contamination caused by the residual sample in the previous sampling step contacting the subsequent sample through the sample needle, the cleanliness of the sample needle before each sampling needs to be ensured. In some embodiments of the utility model, the outer surface area of the needle tip is reduced by reducing the outer diameter of the needle tip, thereby reducing the residue of liquid on the outer surface of the needle tip. Referring to fig. 5, which is a schematic cross-sectional view of the sample needle in the present embodiment, the sample needle 110 may include a first body portion 111 and a first needle tip portion 112, under the driving of a driving mechanism, sample liquid can be sucked into the sample needle through an opening at the head end of the first needle tip portion 112 and can also be discharged through the opening, the first body portion 111 is used for temporarily storing the sample liquid and is connected to the tail end of the first needle tip portion 112, the first body portion 111 is generally long, and fig. 5 shows only a partial structure of the first body portion 111 for clearly displaying the structure of the sample needle.

As shown in the drawings, the first body portion 111 and the second body portion 120 in this embodiment are both cylindrical structures, i.e. the outer diameters of both are kept constant, and since the first needle tip portion 112 is the portion of the sample needle contacting the sample, the reduction of liquid residue on the first needle tip portion 112 helps to avoid cross contamination. In order to reduce the residue, the outer diameter of the first needle tip 112 is reduced, specifically, the outer diameter D of the first needle tip 112 is smaller than or equal to 0.6mm, and as known from the calculation company of the outer peripheral surface area of the cylinder, the outer peripheral surface area of the first needle tip 112 is reduced simultaneously when the outer diameter is reduced, so as to reduce the attachment area of the liquid, that is, when the first needle tip 112 is separated from the liquid surface of the sample, the residual sample attached to the first needle tip 112 is reduced, thereby facilitating the subsequent cleaning step.

Specifically, two kinds of sampling needles were selected, the tip portions of which were cylindrical structures, and the length L of the tip portion of which extended into the sample liquid when sampling was performed was recorded, the length L was selected to be 5mm, the sample needle 1 was designed to have an outer diameter size according to the related art, and the sample needles 2 to 4 were designed to have an outer diameter size according to the present embodiment, and the outer peripheral surface area S calculated from the above data was shown in table 1, and as the outer diameter was decreased, the outer peripheral surface area S was also decreased in synchronization.

TABLE 1

It should be noted that the first needle tip portion 112 may have any value within a range not greater than 0.6mm, and is not limited to the values listed in the above table.

The sample needle needs to be cleaned to remove the residual sample after sampling, however, as the outer diameter of the first needle tip portion 112 is reduced, the strength of the first needle tip portion 112 is also reduced accordingly, which may cause bending due to easy touch with foreign objects during cleaning, and in severe cases may even cause breakage of the sample needle, so the inventor in the art generally does not consider reducing the liquid residue in a manner of reducing the outer diameter of the first needle tip portion 112. The present embodiment adopts a non-contact cleaning method to remove the residual liquid on the first needle tip portion 112 in order to solve the problem of strength reduction of the first needle tip portion 112, thereby avoiding damage to the first needle tip portion 112. In the present invention, the term "non-contact cleaning" means a method in which an operator does not directly contact the sample needle or indirectly contacts the sample needle with a tool, thereby eliminating the damage of the sample needle due to human operation errors. The embodiment can realize non-contact cleaning in an ultrasonic cleaning mode, and the ultrasonic cleaning can promote the separation of a sample adhered to the needle point and has strong cleaning capability.

Based on the above, in some embodiments, the sample analyzing apparatus further includes an ultrasonic cleaning mechanism, not shown, for performing non-contact cleaning of the sample needle, the ultrasonic cleaning mechanism includes a cleaning tank for containing an ultrasonic cleaning liquid, and an ultrasonic sound source assembly for supplying sound field vibration to the ultrasonic cleaning liquid in the ultrasonic cleaning tank, and the liquid path supporting mechanism is for supplying the ultrasonic cleaning liquid into the cleaning tank. Wash remaining sample on first pinpoint portion 112 through cavitation, acceleration action and the direct current effect of ultrasonic wave in liquid, at this in-process, first pinpoint portion 112 only can contact with the washing liquid, and can not contact operator or other instruments, can avoid first pinpoint portion 112 to bump and touch the foreign object and take place to buckle effectively.

Referring to fig. 1, in some embodiments, the sample analysis apparatus may further include a reagent carrying mechanism 700 and a reagent dispensing mechanism 600, and the sample analysis apparatus carries a reagent by the reagent carrying mechanism 700 and performs automatic reagent addition by the reagent dispensing mechanism 600. The reagent carrying mechanism 700 may be a reagent disk having a plurality of reagent sites for carrying reagent containers, and the reagent carrying mechanism 700 can rotate and drive the reagent containers carried by the reagent carrying mechanism 700 to rotate for dispatching the reagent containers to corresponding positions, for example, positions for the reagent dispensing mechanism 600 to suck reagents. The reagent dispensing mechanism 600 includes a moving member and a reagent needle 610, the reagent needle 610 is movable between a reagent site and the above-mentioned placing site by being driven by the moving member so as to aspirate a reagent at the reagent site and discharge the reagent at the placing site, and the moving member may also be a driving member movable in a two-dimensional or three-dimensional space, such as a linear moving device based on motor-screw or motor-timing belt driving.

Referring to fig. 6, fig. 6 is a schematic sectional view of the reagent needle in the present embodiment, and similar to the sample needle 110, the reagent needle 610 is also an elongated tubular structure and is divided according to functions, the reagent needle 610 includes a second main body portion 611 and a second tip portion 612, under the driving of the driving mechanism, a reagent can be sucked into the reagent needle through an opening at the head end of the second tip portion 612 and can be discharged through the opening, the second main body portion 611 is used for temporarily storing the reagent and is connected to the tail end of the second tip portion 612, the second main body portion 611 is generally long, and fig. 6 shows only a partial structure of the second main body portion 611 for clearly showing the structure of the reagent needle.

In some modified implementations of the reagent needle described above, the ratio of the length L of the second needle tip portion 612 to the inner diameter d is defined to be less than or equal to 10. Similarly to the sample needle 110, the reagent needle 610 also needs to transmit power via the liquid medium to suck and discharge the reagent, so that the liquid medium enters the second body portion 611, and on the other hand, to improve efficiency, multiple reagent sets are stored in the second body portion 611, and in order to avoid the liquid medium and the reagent sets from being fused with each other, the reagent needle intermittently sucks air bubbles during reagent suction to separate the liquid medium from the reagent sets and adjacent reagent sets. If the length of the second needle tip portion 612 is too long, the reagent will form a laminar flow due to sufficient development of the flow rate when flowing in the second needle tip portion 612, and the longer the length, the more obvious the phenomenon of fluid stratification is, and the flow rates at different positions in the laminar flow are not consistent, which easily causes bubble collapse. Note that, the second needle tip portion 612 needs to extend to a certain depth below the liquid surface both at the time of sucking the reagent and at the time of discharging the reagent, and therefore the length of the second needle tip portion 612 cannot be too short, for example, not less than 5 mm.

As can be seen from the above, the first connection tube 250 has a long length, needs to occupy a large space, and is easily entangled with other members, thereby affecting the normal operation of the liquid path support mechanism 200, and therefore, the sample analysis apparatus further includes a box 800 and a tube holder 900, as shown in fig. 7 and 8, which are respectively a front view and a perspective view of the connection between the box 800 and the tube holder 900, wherein the box 800 is a main carrier member, and the tube holder 900, the sample carrier mechanism 300, the reaction mechanism 400, the sample dispensing mechanism 100, the measurement unit 500, and the liquid path support mechanism 200 are directly or indirectly mounted thereon. First connecting pipe 250 is fixed through pipe bracket 900, can reduce the space and occupy, realizes placing in order of pipeline.

Referring to fig. 9, the pipe bracket 900 includes a first connecting plate 910 and a fixing member 930, the fixing member 930 is located on the first connecting plate 910, at least a portion of the first connecting pipe 250 is connected to the first connecting plate 910 through the fixing member 930, and the first connecting pipe 250 has at least one bending portion 253, that is, the first connecting pipe 250 is fixed to the first connecting portion 910 after being bent at least once, so that the space occupied by the first connecting pipe 250 can be reduced. The bent portion 253 in this embodiment may be formed by naturally bending a soft pipe, and may have a substantially arc shape, and the bending angle of the bent portion 253 is not limited to the illustrated angle, and may be arbitrarily set according to the layout of the inside of the case 800. When a plurality of bent portions 253 are provided, the bent angles of the bent portions 253 may be the same or different.

To simplify the manufacturing process, the pipe bracket 900 may be a metal part formed by a sheet metal process or a hard plastic part formed by an integral process such as injection molding. For example, the first connecting plate 910 is a thin metal plate, the fixing member 930 may be a protrusion formed by punching, a gap is formed between the protrusion and the first connecting plate 910, and a fastener such as a ribbon may pass through the gap below the fixing member 930 and be bundled on the first connecting tube 250 to achieve fixing. The pipe bracket 900 may include a plurality of fixing members 930, and the plurality of fixing members 930 are sequentially arranged in the direction of the first connection pipe 250 to fix the first connection pipe 250 at multiple points. In other embodiments, the fixing member 930 may be a separate member that is separate from the first connection plate 910 and is connected to the first connection plate 910 by welding, clipping, or screwing.

Referring to fig. 10, a first connecting tube 250 is shown by a dot-dash line, and the first connecting tube 250 at least includes a first vertical tube section 251, a second vertical tube section 252 and a bent portion 253, wherein the first vertical tube section 251 is used as a movable end, and the top end thereof is connected with the sample needle 110 and can move synchronously along the vertical direction along with the sample needle 110. The second upright tube section 252 is fixed end, fixed above the first connection plate 910 by a fixing member 930. The second installation pipe section 252 is connected to the first vertical pipe section 251 through a bending portion 253, so that the first connection pipe 250 can be bent to reduce the space occupied by the first connection pipe 250, and the bending portion 253 can be used as a buffer portion for the movement of the first vertical pipe section 251 to facilitate the vertical movement of the first vertical pipe section 251. In this embodiment, the first vertical pipe section 251 and the second vertical pipe section 252 are separated by a predetermined distance, and the bending portion 253 is an arc pipe section with an angle of approximately 180 °, so as to increase the stroke of the first vertical pipe section 251 in up-and-down movement. It should be noted that the term "vertical pipe section" in the present invention does not mean a vertical state in which the pipe section needs to be strictly maintained, that is, the pipe section is allowed to have a certain inclination so as to extend in a substantially vertical direction.

With continued reference to fig. 10, to further achieve compression of first connecting tube 250, first connecting tube 250 further includes a first horizontal tube segment 254 and a second horizontal tube segment 255, first horizontal tube segment 254 is connected to second vertical tube segment 252 by a bent portion 253, and second horizontal tube segment 255 is connected to first horizontal tube segment 254 by a bent portion 253. Like the second vertical pipe section 252, the first horizontal pipe section 254 and the second horizontal pipe section 255 are fixed on the first connection plate 910 by a fixing member 930 to increase the stability of the connection of the first connection pipe 250.

It should be noted that, when the sample analysis apparatus is provided with a plurality of sample needles 110, the liquid path support mechanism 200 is correspondingly provided with a plurality of first connection tubes 250, and as shown in fig. 10 in particular, two first connection tubes 250 are respectively connected to two sample needles 110 and are both fixed by the first connection plate 910.

In some embodiments of the present invention, the pipe bracket 900 further includes a second connection plate 920 to enable the turning of the first connection pipe 250, the second connection plate 920 is connected to one side of the first connection plate 910 with an angle α therebetween, wherein 0 < α < 180 °, a portion of the first connection pipe 250 extends from the first connection plate 910 to the second connection plate 920 and is fixed by a fixing member 930. Taking fig. 10 as an example, the second connecting plate 920 is connected to the left side of the first connecting plate 910 and is disposed perpendicular to the first connecting plate 910, the first connecting pipe 250 further includes a third horizontal pipe segment 256, and the third horizontal pipe segment 256 is connected to the second horizontal pipe segment 255 through a bending portion 253, so that the first connecting pipe 250 can be converted from extending in the left-right direction to extending in the front-back direction.

It should be noted that the second connecting plate 920 and the first connecting plate 910 may be metal plates, and may be integrally formed through a bending process, or may be connected into an integral structure through a welding process or the like. The angle α between the second connecting plate 920 and the first connecting plate 910 can be adjusted to other angles according to the desired orientation of the first connecting tube 250. The pipeline bracket 900 may be provided with a plurality of second connection plates 920, the plurality of second connection plates 920 are connected to different edges of the first connection plate 910, and may extend toward the same side or different sides of the first connection plate 910, as shown in the figure, the pipeline bracket 900 is provided with two second connection plates 920, which are respectively located at the left and right sides of the first connection plate 910, and extend toward the front and rear sides of the first connection plate 910, respectively, so as to implement multiple fixing manners of the connection pipes; in addition, when the plurality of first connection pipes 250 are fixed by the pipe bracket 900, the first vertical pipe sections 251 may be spaced apart by the first connection plates 910 and the second connection plates 920, thereby preventing the first vertical pipe sections 251 from interfering with each other when moving.

In some embodiments of the present invention, the box body 800 includes a frame 810 and a mounting plate 820, and the frame 810 may be formed by welding members such as profiles, and has high strength and relatively light weight. Mounting panel 820 is connected through modes such as threaded connection, welding with frame 810, and the below of mounting panel 820 is formed with installation space, and foretell pipeline bracket 900 is located installation space, and is connected with mounting panel 820's downside, and pipeline bracket 900 can correspond the chamber door setting of box 800, so, when the chamber door is in the open mode, pipeline bracket 900 is in the position that can the direct operation, the operator dismouting connecting pipe of being convenient for.

In order to fix the mounting plate 820 and the pipe bracket 900, the pipe bracket 900 further includes a third connecting plate 940, the third connecting plate 940 is located on the upper side of the first connecting plate 910 and is horizontally disposed, and during installation, the third connecting plate 940 is attached to the lower surface of the mounting plate 820 and is fixed by a threaded fastener.

In addition, the mounting plate 820 is also provided with a through hole, not shown, through which the first vertical pipe section 251 of the first connecting pipe 250 can pass upward and be connected with the sample needle 110 located at the upper side of the case 800.

The embodiments of the present invention have been described in detail with reference to the accompanying drawings, but the present invention is not limited to the above embodiments, and various changes can be made within the knowledge of those skilled in the art without departing from the gist of the present invention. Furthermore, the embodiments of the present invention and the features of the embodiments may be combined with each other without conflict.

Claims

1. A sample analysis apparatus, comprising:

a measuring unit for measuring a reaction solution to be measured;

liquid way supporting mechanism, liquid way supporting mechanism includes water tank, water pump, control valve and syringe, the water tank the water pump the control valve the syringe with the sample needle passes through the connecting pipe and connects gradually, wherein, the syringe with between the sample needle the connecting pipe is first connecting tube, the length of first connecting tube is 1400mm to 1600mm, and the internal diameter is 0.92mm to 1.12 mm.

2. The sample analysis apparatus according to claim 1, wherein the fluid path support mechanism further comprises at least one adaptor, a plurality of the first connection tubes are provided between the syringe and the sample needle, and adjacent first connection tubes are connected by the adaptor.

3. The sample analysis apparatus of claim 1, wherein the fluid path support mechanism further comprises a pressure sensor connected between the sample needle and the syringe through the first connection tube.

4. The sample analysis apparatus of claim 1, wherein the connection tube between the control valve and the syringe is a second connection tube having a length of 400mm to 600 mm.

5. The sample analysis device of claim 4, wherein the second connecting tube has an inner diameter of 1.3mm to 1.7 mm.

6. The sample analysis apparatus according to claim 4, wherein the fluid path support mechanism further comprises at least one adaptor, and a plurality of second connection pipes are provided between the control valve and the syringe, and adjacent second connection pipes are connected by the adaptor.

7. The sample analysis device of claim 4, wherein the fluid circuit support mechanism further comprises a pressure sensor connected between the control valve and the syringe through the second connecting tube.

8. The sample analysis apparatus of claim 1, wherein the sample needle comprises a first body portion and a first needle tip portion connected to the first body portion and having a constant outer diameter, wherein the outer diameter of the first needle tip portion is ≦ 0.6 mm;

9. The sample analysis apparatus of claim 1, further comprising a reagent dispensing mechanism comprising a reagent needle comprising a second body portion and a second tip portion, the second tip portion being connected to the second body portion and having a constant inner diameter, wherein a ratio of a length of the second tip portion to the inner diameter is less than or equal to 10.

10. The sample analyzer of claim 1, further comprising a housing and a tube holder, wherein the sample holder, the reaction mechanism, the sample dispensing mechanism, the measuring member, the liquid path supporting mechanism, and the tube holder are all connected to the housing, and the tube holder comprises a first connecting plate and a fixing member, and at least a portion of the first connecting tube is connected to the first connecting plate through the fixing member, so that the first connecting tube has at least one bending portion.

11. The sample analysis apparatus of claim 10, wherein the first connection tube comprises a first vertical tube section and a second vertical tube section, the second vertical tube section is connected to the first connection plate through the fixing member, the first vertical tube section is connected to the sample needle and can move synchronously with the sample needle, and the first vertical tube section and the second vertical tube section are connected through the bending portion.

12. The sample analysis device of claim 10, wherein the conduit support further comprises a second connection plate connected to the first connection plate and having an included angle α, wherein 0 < α < 180 °, wherein a portion of the first connection tube is connected to the second connection plate by the fastener.

13. The sample analysis device of claim 10, wherein the housing comprises a frame and a mounting plate, the mounting plate is connected to the frame, and a mounting space is formed below the mounting plate, and the pipe bracket is located in the mounting space and connected to a lower side of the mounting plate.