CN216855380U - Warm air type bioreactor thermostat - Google Patents

Warm air type bioreactor thermostat Download PDF

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Publication number
CN216855380U
CN216855380U CN202122832992.2U CN202122832992U CN216855380U CN 216855380 U CN216855380 U CN 216855380U CN 202122832992 U CN202122832992 U CN 202122832992U CN 216855380 U CN216855380 U CN 216855380U
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bioreactor
inlet
medium
heat
cavity
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刘路
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Zhejiang Tonggan Medical Technology Co.,Ltd.
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Wuhan Togo Meditech Co ltd
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Abstract

The application relates to the technical field of medical equipment, provides warm braw formula bioreactor constant temperature equipment, includes: the constant temperature box is provided with a medium inlet and a medium outlet which are communicated with the inside of the constant temperature box; a heat supply pipe having one end communicating with the medium inlet; a return pipe having one end communicating with the medium outlet; the warm air blower is communicated with the other end of the heat supply pipe and is used for inputting heat-conducting media into the constant temperature box; and the exhaust fan is communicated with the other end of the return pipe and is used for pumping out the heat-conducting medium in the constant temperature box. Because the gas is used as the heat conducting medium, compared with a liquid heat conducting medium, when a certain interface of the bioreactor has micro leakage, whether the leakage exists is judged easily by observing whether residual liquid or stain exists on the outer wall of the bioreactor, and in addition, the leakage can not cause the liquid in the bioreactor to be polluted, and the operation of the bioartificial liver system can not be influenced.

Description

Warm air type bioreactor thermostat
Technical Field
The utility model belongs to the technical field of medical instruments, and particularly relates to a warm air type bioreactor constant temperature device.
Background
The bioreactor is the core part of the bioartificial liver system acting on cells, and the performance of the bioreactor is directly related to the support and treatment effect of the artificial liver system. The bioreactor which is the most widely researched and applied at present is a hollow fiber type reactor, the structure of the reactor is generally composed of a cylindrical reactor shell and hollow fibers filled in the shell, the hollow fibers are arranged in a bundle, and the wall of the hollow fibers is provided with small holes for exchange. In order to improve the efficiency of the bioreactor, the prior art is to place the bioreactor in a water tank, fill the water tank with hot water, and heat the bioreactor with the hot water. However, this method has a risk of leakage, if there is a problem in sealing, hot water will be replaced with nutrient solution or cell sap in the bioreactor, and when a small leakage occurs at a certain interface of the bioreactor, it is difficult to find the leakage point in time due to the influence of water in the water tank.
SUMMERY OF THE UTILITY MODEL
The utility model aims to solve the problems that the existing water tank heating type bioreactor heating device is difficult to find leakage and has large leakage influence, and provides a warm air type bioreactor constant temperature device.
The utility model provides a warm air type bioreactor constant temperature device, comprising:
the constant temperature box is provided with a medium inlet and a medium outlet which are communicated with the interior of the constant temperature box;
a heat supply pipe having one end communicating with the medium inlet;
a return pipe having one end communicating with the medium outlet;
the warm air blower is communicated with the other end of the heat supply pipe and is used for inputting heat-conducting media into the constant temperature box; and
the exhaust fan is communicated with the other end of the return pipe and is used for pumping out the heat-conducting medium in the constant temperature box;
wherein at least one bioreactor surrounded by the heat-conducting medium is placed in the incubator; the incubator is provided with mounting ports which are in one-to-one correspondence with the interfaces on the bioreactor, so that the interfaces of the bioreactor penetrate out of the incubator.
Further, the incubator comprises an incubator body and an incubator cover, and the incubator body is detachably connected with the incubator cover; the interface on the bioreactor comprises a plasma inlet, a plasma outlet, a nutrient solution inlet and a nutrient solution outlet; the mounting port includes a plurality of nutrient solution ports and a plurality of plasma ports.
Still further, the bioreactor is horizontally arranged in the box body; the nutrient solution port is arranged on the box cover, and the blood plasma port is arranged at the joint of the box cover and the box body; the two nutrient solution ports are respectively matched with the nutrient solution inlet and the nutrient solution outlet, and the two plasma ports are respectively matched with the plasma inlet and the plasma outlet.
Preferably, a sealing ring is sleeved on the interface of the bioreactor and penetrates through the mounting port, and the sealing ring is connected with the mounting port in a sealing manner.
The beneficial effects of the above preferred scheme are: through set up the sealing washer on the interface, make sealing washer and installing port sealing connection, guaranteed the leakproofness of being connected of bioreactor and thermostated container, avoid the heat conduction medium in the thermostated container to spill over from the installing port.
Further, a fixing part for fixing the bioreactor is arranged in the incubator.
Fix bioreactor through the mounting, can avoid bioreactor to take place the displacement under the effect of heat conduction medium, also can be through the injecing to bioreactor position, make a plurality of bioreactors evenly arrange in the thermostated container, each bioreactor is heated evenly.
Preferably, warm braw formula bioreactor constant temperature equipment still includes the kuppe, the kuppe is the corrugated hose of loudspeaker form, and it has along the major axis end and the microcephaly end that the axial is linked together, microcephaly end with the air intake intercommunication of electric fan heater, the air outlet of air exhauster is directional the major axis end.
Through the effect of kuppe, can retrieve and gather together the heat-conducting medium that is higher than ambient air temperature that blows off the air outlet of air exhauster to inhale once more by the air intake of electric fan heater, realize the reuse of heat-conducting medium, the energy saving.
In one embodiment, the box body comprises a bottom plate and an inner barrel, a middle barrel and an outer barrel which are concentric and have different diameters and are erected on the bottom plate; the inner cavity of the inner cylinder is a medium inlet cavity, and the area between the inner cylinder and the middle cylinder is a pipeline cavity; the area between the middle barrel and the outer barrel is a heating cavity; the plurality of bioreactors are uniformly distributed in the heating cavity along the circumferential direction of the middle cylinder, and a nutrient solution inlet and a nutrient solution outlet of each bioreactor penetrate through the middle cylinder and extend into the pipeline cavity; the plasma inlet of the bioreactor passes through the box cover, and the plasma outlet of the bioreactor passes through the bottom plate; the medium inlet comprises a first inlet and a second inlet, the first inlet penetrates through the box cover to be communicated with the medium inlet cavity, one end of the second inlet extends into the medium inlet cavity, and the other end of the second inlet extends into the heating cavity and is used for conveying heat-conducting medium into the heating cavity; the medium outlet is arranged on the outer cylinder and used for discharging heat-conducting media in the heating cavity.
The beneficial effects of the above embodiment are: the box body is arranged into the inner cylinder, the middle cylinder and the outer cylinder, so that the plurality of bioreactors can be uniformly heated.
Further, heating intracavity is provided with plum blossom shape radome fairing with one heart, the inner chamber of radome fairing is formed with a plurality of edges that are linked together the circumference evenly distributed's of well section of thick bamboo heat preservation chamber, still evenly be provided with a plurality of intercommunications on the radome fairing heat preservation chamber with the overflow mouth in heating chamber, stretching into of second entry one end in the heating intracavity is located the heat preservation intracavity, heat preservation intracavity is provided with bioreactor.
The beneficial effects of the further scheme are as follows: through the radome fairing that has the effect of gathering heat in heating intracavity setting to form the heat preservation chamber, make the constant temperature heating effect that is located the bioreactor of heat preservation intracavity better, the intensification is rapid, and the cooling is slow, has improved bioreactor's reaction efficiency.
Further preferably, the fairing is formed by a plurality of arc flow baffles in an enclosing mode.
The utility model has the beneficial effects that: the high-temperature gas blown out by the fan heater is used as a heat conducting medium, the heat conducting medium enters the incubator to heat the bioreactor under the flow guiding action of the heat supply pipe, and the exhaust fan is used for pumping out the heat conducting medium in the incubator, so that the temperature of the heat conducting medium in the incubator is in a dynamic balance state, and the bioreactor in the incubator is heated uniformly. The cells in the bioreactor are always kept in a high activity state, and the reaction efficiency of the bioreactor is ensured. Because the gas is used as the heat conducting medium, compared with a liquid heat conducting medium, when a certain interface of the bioreactor has micro leakage, whether the leakage exists is judged easily by observing whether residual liquid or stain exists on the outer wall of the bioreactor, and in addition, the leakage can not cause the liquid in the bioreactor to be polluted, and the operation of the bioartificial liver system can not be influenced.
Drawings
FIG. 1 is a schematic structural diagram of an embodiment of the warm air type bioreactor thermostat according to the present invention.
FIG. 2 is a schematic sectional view A-B-A of the incubator of FIG. 1.
FIG. 3 is a schematic perspective view of a bioreactor and a buckle disposed thereon in FIG. 2.
FIG. 4 is a schematic perspective view of another embodiment of the incubator of the constant temperature apparatus for a warm air type bioreactor according to the present invention.
Fig. 5 is a schematic sectional top view of the case of fig. 4.
FIG. 6 is a schematic perspective view of a bioreactor and a buckle disposed thereon in FIG. 5.
FIG. 7 is a schematic view of the structure of the heat transfer medium flow trace of FIG. 5 with the bioreactor removed.
In the figure, 1.1-heating pipe; 1.2-reflux tube; 2-a media inlet; 2.1-a first inlet; 2.2-a second inlet; 3-a medium outlet; 4, warm air blower; 5-an exhaust fan; 6, a box body; 7-box cover; 8-a shell; 9-plasma inlet; 10-plasma outlet; 11-nutrient solution inlet; 12-nutrient solution outlet; 14-buckling; 15-a base plate; 16-inner cylinder; 17-a middle cylinder; 18-an outer barrel; 19-media entry chamber; 20-a line cavity; 21-heating chamber; 22-a fairing; 23-heat preservation cavity; 24-an overflow port; 25-a flow baffle; 26-air guide sleeve.
Detailed Description
The utility model is described in further detail below with reference to figures 1 to 7 and the specific embodiments.
Example 1
The warm air type bioreactor thermostat as shown in fig. 1 to 3 includes: a constant temperature box, a heat supply pipe 1.1, a return pipe 1.2, a warm air blower 4, an exhaust fan 5 and a flow guide cover 26.
The incubator is provided with a medium inlet and a medium outlet which are communicated with the inside of the incubator. At least one bioreactor surrounded by heat-conducting media is placed in the incubator; the incubator is provided with mounting ports which correspond to the interfaces on the bioreactor one by one so that the interfaces of the bioreactor penetrate out of the incubator.
One end of the heating pipe 1.1 is communicated with the medium inlet, and the other end of the heating pipe 1.1 is communicated with the air outlet of the warm air blower 4.
One end of the return pipe 1.2 is communicated with the medium outlet, and the other end of the return pipe 1.2 is communicated with the air inlet of the exhaust fan 5.
The warm air blower 4 adopts the prior art, after air enters from an air inlet, the air is heated to form a heat conducting medium, the heat conducting medium is blown out from an air outlet of the warm air blower to the heat supply pipe 1.1, and the heat supply pipe 1.1 conveys the heat conducting medium to the incubator so as to surround the bioreactor in the incubator.
The exhaust fan 5 may also be an existing device which draws out the heat-conducting medium in the incubator so that a new heat-conducting medium can enter the incubator, thereby forming a dynamic balance of the heat-conducting medium in the incubator and keeping the heat-conducting medium in a higher constant temperature state all the time. It should be noted that the medium inlet and the medium outlet should be oppositely disposed at two side ends of the oven, so that the circulation path of the heat-conducting medium in the oven is maximized, and energy loss is avoided.
In order to further reduce the energy waste, a flow guide 26 is arranged between the fan heater 4 and the exhaust fan 5. The air guide sleeve 26 is not fixed, and the position and the angle can be adjusted according to actual conditions.
The air guide sleeve 26 is a horn-shaped corrugated hose and is provided with a large head end and a small head end which are communicated along the axial direction, the small head end is communicated with the air inlet of the fan heater 4, and the air outlet of the exhaust fan 5 points to the large head end. The heat-conducting medium which is blown out from the air outlet of the exhaust fan 5 and is discharged from the thermostat and has reduced temperature enters the air guide sleeve 26, is sucked again by the fan heater 4 and then is heated to the required temperature to form the heat-conducting medium reaching the required temperature, and is conveyed into the thermostat again.
The constant temperature box comprises a box body 6 and a box cover 7, wherein the box body 6 is detachably connected with the box cover 7; the bioreactor comprises a shell 8, and the interface on the bioreactor comprises a plasma inlet 9, a plasma outlet 10, a nutrient solution inlet 11 and a nutrient solution outlet 12 which are arranged on the shell 8. Wherein the plasma inlet 9 and the plasma outlet 10 are arranged at both axial ends of the housing 8. A nutrient solution inlet 11 and a nutrient solution outlet 12 are provided at the side ends of the housing 8.
The mounting port on the incubator includes a plurality of nutrient solution ports and a plurality of plasma ports.
The shell 8 of the bioreactor is horizontally arranged in the box body 6; the nutrient solution port is arranged on the box cover 7, and the plasma port is arranged at the joint of the box cover 7 and the box body 6. The two nutrient solution ports are respectively matched with the nutrient solution inlet 11 and the nutrient solution outlet 12, and the two plasma ports are respectively matched with the plasma inlet 9 and the plasma outlet 10. When the number of the bioreactors is more, the corresponding nutrient solution port and the corresponding plasma port are correspondingly increased and arranged at corresponding positions.
The interface of the bioreactor is sleeved with a sealing ring and penetrates through the mounting opening, and the sealing ring is connected with the mounting opening in a sealing way. Through set up the sealing washer on the interface, make sealing washer and installing port sealing connection, guaranteed the sealing nature of being connected of bioreactor and thermostated container, avoid the heat conduction medium in the thermostated container to spill over from the installing port.
A fixing part for fixing the bioreactor is arranged in the constant temperature box. The securing member is a snap 14 or clip. The preferred fastener in this embodiment is a clasp 14. Fix bioreactor through the mounting, can avoid bioreactor to take place the displacement under the effect of heat conduction medium, also can be through the injecing to bioreactor position, make a plurality of bioreactors evenly arrange in the thermostated container, each bioreactor is heated evenly.
It should be noted that, after the bioreactor is disposed in the incubator, since the bioreactor is of an integrally formed structure and the interfaces connecting with the bioreactor system (existing system) are all located outside the incubator, the incubator and the heat conducting medium inside the incubator will not affect the use of the bioreactor. Namely, the use of the incubator and the bioreactor do not interfere with each other.
Because the whole bioreactor is surrounded by the heat conducting medium, the heating is uniform and stable, the cells in the bioreactor are always kept in a high activity state, and the reaction efficiency of the bioreactor is ensured.
Example 2
As shown in fig. 4 to 7, the structure of the warm air type bioreactor thermostat of the present embodiment is substantially the same as that of embodiment 1, except that the specific structure of the thermostat is different:
the case 6 of the present example is cylindrical, and the case 6 of the example 1 is cubic. The box body 6 of the embodiment comprises a bottom plate 15, an inner cylinder 16, a middle cylinder 17 and an outer cylinder 18 which are concentric with each other and have different diameters and are erected on the bottom plate 15; the inner cavity of the inner cylinder 16 is a medium inlet cavity 19, and the area between the inner cylinder 16 and the middle cylinder 17 is a pipeline cavity 20; the area between the middle barrel 17 and the outer barrel 18 is a heating cavity 21; a plurality of bioreactors are evenly distributed in the heating cavity 21 along the circumference of the middle barrel 17, a nutrient solution inlet 11 and a nutrient solution outlet 12 of each bioreactor penetrate through the middle barrel 17 and extend into the pipeline cavity 20, pipeline penetrating ports are further formed in positions, corresponding to the pipeline cavity 20, of the box cover 7, pipelines of the biological reaction system penetrate through the corresponding pipeline penetrating ports and then are communicated with the nutrient solution inlet 11 or the nutrient solution outlet 12, and therefore the biological reaction system can provide nutrient solution for the bioreactors. The plasma inlet 9 of the bioreactor passes through the lid 7 and the plasma outlet 10 of the bioreactor passes through the base 15. The medium inlet 2 of the present embodiment comprises a first inlet 2.1 and a second inlet 2.2. The first inlet 2.1 penetrates through the box cover 7 to be communicated with the medium inlet cavity 19, one end of the second inlet 2.2 extends into the medium inlet cavity 19, and the other end of the second inlet 2.2 extends into the heating cavity 21 to convey heat-conducting medium into the heating cavity 21. With the cooperation of the first inlet 2.1 and the second inlet 2.2, an external heat-conducting medium is introduced into the heating chamber 21. The medium outlet 3 is provided on the outer cylinder 18 for discharging the heat transfer medium in the heating chamber 21.
The heating chamber 21 is internally concentrically provided with a quincunx fairing 22, the inner cavity of the fairing 22 is formed with a plurality of communicated heat preservation chambers 23 which are uniformly distributed along the circumference of the middle cylinder 17, the fairing 22 is also uniformly provided with a plurality of overflow ports 24 which are communicated with the heat preservation chambers 23 and the heating chamber 21, one end of the second inlet 2.2 which extends into the heating chamber 21 is positioned in the heat preservation chamber 23, and the heat preservation chamber 23 is internally provided with a bioreactor. The fairing 22 is formed by a plurality of arcuate baffles 25.
The buckle 14 is fixed on the outer wall of the middle cylinder 17.
In this embodiment, there are four insulated chambers 23, and each insulated chamber 23 has a bioreactor therein. There are one first inlet 2.1 and four second inlets 2.2, and there are one second inlet 2.2 at the juncture of every two adjacent chambers 23 and correspondingly there are four media outlets 3. The arrows in fig. 7 indicate the direction of flow of the heat transfer medium. When the system of the embodiment operates, air heated by the fan heater 4, that is, heat-conducting medium, is conveyed to the medium inlet cavity 19 (the medium inlet cavity 19 is communicated with the heat supply pipe 1.1), the heat-conducting medium in the medium inlet cavity 19 uniformly flows into the corresponding four heat preservation cavities 23 from the four second inlets 2.2, and rapidly wraps the bioreactor in the heat preservation cavities 23, and then flows out to the heating cavity 21 from the overflow port 24, and finally flows out to the return pipe 1.2 from the medium outlet 3, and is discharged under the action of the exhaust fan 5.
The above description is only a preferred embodiment of the present invention, and the protection scope of the present invention is not limited to the above embodiments, and all technical solutions belonging to the idea of the present invention belong to the protection scope of the present invention. It should be noted that modifications and embellishments within the scope of the utility model may be made by those skilled in the art without departing from the principle of the utility model.

Claims (9)

1. A warm air type bioreactor thermostat device is characterized by comprising:
the constant temperature box is provided with a medium inlet and a medium outlet which are communicated with the interior of the constant temperature box;
a heat supply pipe having one end communicating with the medium inlet;
a return pipe having one end communicating with the medium outlet;
the warm air blower is communicated with the other end of the heat supply pipe and is used for inputting heat-conducting media into the constant temperature box; and
the exhaust fan is communicated with the other end of the return pipe and is used for pumping out the heat-conducting medium in the constant temperature box;
wherein at least one bioreactor surrounded by the heat-conducting medium is placed in the incubator; the incubator is provided with mounting ports which are in one-to-one correspondence with the interfaces on the bioreactor, so that the interfaces of the bioreactor penetrate out of the incubator.
2. The warm-air bioreactor thermostat of claim 1, wherein the thermostat comprises a box body and a box cover, the box body being detachably connected to the box cover; the interface on the bioreactor comprises a plasma inlet, a plasma outlet, a nutrient solution inlet and a nutrient solution outlet; the mounting port includes a plurality of nutrient solution ports and a plurality of plasma ports.
3. The warm-air bioreactor thermostat of claim 2 wherein the bioreactor is horizontally disposed within the tank; the nutrient solution port is arranged on the box cover, and the blood plasma port is arranged at the joint of the box cover and the box body; the two nutrient solution ports are respectively matched with the nutrient solution inlet and the nutrient solution outlet, and the two plasma ports are respectively matched with the plasma inlet and the plasma outlet.
4. The warm air type bioreactor thermostat device as claimed in claim 1, wherein a sealing ring is sleeved on the interface of the bioreactor and passes through the mounting port, and the sealing ring is connected with the mounting port in a sealing manner.
5. The warm-air bioreactor thermostat of claim 1, wherein a fixture for securing the bioreactor is provided within the incubator.
6. The warm-air bioreactor thermostat of claim 1, further comprising a dome, wherein the dome is a horn-shaped corrugated hose having a large end and a small end that are axially communicated, the small end is communicated with an air inlet of the fan heater, and an air outlet of the exhaust fan points to the large end.
7. The warm-air bioreactor thermostat of claim 2, wherein the box body comprises a bottom plate and an inner barrel, a middle barrel and an outer barrel which are concentric and have different diameters and are erected on the bottom plate; the inner cavity of the inner cylinder is a medium inlet cavity, and the area between the inner cylinder and the middle cylinder is a pipeline cavity; the area between the middle barrel and the outer barrel is a heating cavity; the plurality of bioreactors are uniformly distributed in the heating cavity along the circumferential direction of the middle cylinder, and a nutrient solution inlet and a nutrient solution outlet of each bioreactor penetrate through the middle cylinder and extend into the pipeline cavity; a plasma inlet of the bioreactor passes through the tank cover, and a plasma outlet of the bioreactor passes through the bottom plate; the medium inlet comprises a first inlet and a second inlet, the first inlet penetrates through the box cover to be communicated with the medium inlet cavity, one end of the second inlet extends into the medium inlet cavity, and the other end of the second inlet extends into the heating cavity and is used for conveying heat-conducting medium into the heating cavity; the medium outlet is arranged on the outer cylinder and used for discharging heat-conducting media in the heating cavity.
8. The warm air type bioreactor thermostat device according to claim 7, characterized in that a quincunx fairing is concentrically arranged in the heating cavity, a plurality of communicated heat preservation cavities are formed in an inner cavity of the fairing and are uniformly distributed along the circumference of the middle cylinder, a plurality of overflow ports communicated with the heat preservation cavities and the heating cavity are uniformly arranged on the fairing, one end of the second inlet extending into the heating cavity is positioned in the heat preservation cavity, and the bioreactor is arranged in the heat preservation cavity.
9. The warm-air bioreactor thermostat of claim 8, wherein the cowling is enclosed by a plurality of arcuate baffles.
CN202122832992.2U 2021-11-18 2021-11-18 Warm air type bioreactor thermostat Active CN216855380U (en)

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Application Number Priority Date Filing Date Title
CN202122832992.2U CN216855380U (en) 2021-11-18 2021-11-18 Warm air type bioreactor thermostat

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Application Number Priority Date Filing Date Title
CN202122832992.2U CN216855380U (en) 2021-11-18 2021-11-18 Warm air type bioreactor thermostat

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN117388696A (en) * 2023-12-12 2024-01-12 江苏天合储能有限公司 Incubator simulation model, incubator and constant temperature room

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN117388696A (en) * 2023-12-12 2024-01-12 江苏天合储能有限公司 Incubator simulation model, incubator and constant temperature room

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Address after: 4th floor, podium building, Gongtou Building, No. 433-505 Chunhui Road, Lingxi Town, Cangnan County, Wenzhou City, Zhejiang Province, 325000

Patentee after: Zhejiang Tonggan Medical Technology Co.,Ltd.

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