CN216824925U - Liquid chromatography separation column - Google Patents
Liquid chromatography separation column Download PDFInfo
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- CN216824925U CN216824925U CN202220411425.1U CN202220411425U CN216824925U CN 216824925 U CN216824925 U CN 216824925U CN 202220411425 U CN202220411425 U CN 202220411425U CN 216824925 U CN216824925 U CN 216824925U
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- chromatography separation
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Abstract
The utility model discloses a liquid chromatography separation column belongs to liquid chromatography separation column technical field. A liquid chromatography separation column comprising a column body, further comprising: a threaded ring slidably connected to the post; the convex rings are fixedly connected to the two ends of the column body and used for limiting the threaded rings; the annular air bag is fixedly connected to the inner side of the convex ring close to the threaded ring; the utility model discloses a screw ring screw thread is screwed up on the screw post, and the screw ring extrudees annular gasbag and makes annular sealed gasbag and spout admit air, and annular sealed gasbag is hugged closely with the screw post terminal surface, packs the gap between cylinder and the screw post, improves the leakproofness, prevents to appear the weeping; the gas that enters into in the spout simultaneously promotes the stopper and enters into the spacing groove, with the reference column chucking on the screw post for the cylinder installation is firm, avoids rocking, prevents the gap increase between cylinder and the screw post, and further improvement leakproofness prevents to leak gas, and then prevents to produce the weeping under high-pressure operational environment.
Description
Technical Field
The utility model relates to a liquid chromatography separation column technical field especially relates to a liquid chromatography separation column.
Background
High performance liquid chromatography is the most commonly used technique in modern pharmaceutical testing. The separation principle of chromatography is to separate various substances to be separated by utilizing the difference of affinity capacities such as partition coefficient, adsorption capacity and the like of the substances in two phases. It technically adopts high-pressure pump, high-effective stationary phase and high-sensitivity detector, so that it possesses the characteristics of high speed, high efficiency, high sensitivity and automatic operation.
Modern liquid chromatographic separation is generally high performance liquid chromatographic separation, and high performance liquid chromatographic instruments are required for separation and preparation. The structure of a high performance liquid chromatography instrument is generally divided into 4 main parts: the device comprises a high-pressure transfusion system, a sample introduction system, a separation system and a detection system. The working process is as follows: the mobile phase and the solvent in the liquid reservoir are firstly sent into the chromatographic separation column by a high-pressure pump through a sample injector and then flow out from the outlet of the controller. When a sample to be separated is injected, the mobile phase flowing through the sample injector liquid reservoir simultaneously brings the sample into a chromatographic separation column for separation, then the sample enters a detector in sequence, and a recorder records signals sent by the detector, so that a liquid chromatogram is obtained.
When the chromatographic separation column is used, the chromatographic separation column needs to work under high pressure, the sealing performance of the chromatographic separation column becomes an important problem under high pressure, the chromatographic separation column must have no air leakage gap or air leakage gap, and liquid leakage is easily generated under high pressure in the working process to influence the separation effect. The leakage is a problem which often occurs when the existing liquid chromatography separation column is used. In addition, the installation of present chromatographic fractionation post is all that artifical manual twisting is connected respectively on the column joint of introduction port and detector, and the column joint links to each other with introduction port and detector respectively through thin steel pipe, and when installing chromatographic fractionation post, the easy unstable problem of installation that produces carelessly slightly easily leads to the chromatographic fractionation post to appear rocking when using easily, causes the gap increase between chromatographic fractionation post and the connecting piece, and the more serious problem of weeping phenomenon takes place.
SUMMERY OF THE UTILITY MODEL
The utility model aims to solve the problem that the liquid leakage phenomenon is caused after the gap is generated between the chromatographic separation column and the connecting piece; and the chromatographic separation column has the installation insecure when the installation, leads to the chromatographic separation column to appear rocking when using easily, causes the gap increase between chromatographic separation column and the connecting piece, the more serious problem of weeping phenomenon.
In order to achieve the above purpose, the utility model adopts the following technical scheme:
a liquid chromatography separation column comprising a column body, further comprising: a threaded ring slidably connected to the post; the convex rings are fixedly connected to the two ends of the column body and used for limiting the threaded rings; the annular air bag is fixedly connected to the inner side of the convex ring close to the threaded ring; the threaded ring is rotationally locked on the threaded column, an annular sealing air bag is fixedly connected to the end face of the column body, the annular sealing air bag is attached to the end face, close to the column body, of the threaded column, and the annular sealing air bag is communicated with the annular air bag through a connecting pipe; fixed connection be in the reference column of cylinder terminal surface, the constant head tank has been seted up on the screw post, the reference column is corresponding with the constant head tank, the spout has all been seted up to the reference column both sides, sliding connection has the stopper in the spout, fixedly connected with extension spring between stopper and the spout, the spacing groove has all been seted up to the constant head tank both sides, the stopper is corresponding with the spacing groove, be linked together through the trachea between spout and the annular gasbag.
In order to facilitate the rotational locking of the threaded ring on the threaded stud, the threaded ring is preferably screwed onto the threaded stud.
In order to facilitate not changing the contact area between the cylinder and the threaded column and further improve the stability of the cylinder after installation, further, an accommodating groove is formed in the end face of the cylinder, and the annular sealing air bag is fixedly connected in the accommodating groove.
In order to improve the firm effect after the cylinder installation, further, the reference column is the symmetry setting.
In order to avoid the rotation of the column body during installation, furthermore, the positioning column is positioned at the eccentric position of the column body.
In order to improve the steadiness of reference column in the constant head tank, further, reference column and constant head tank are the symmetry setting.
Compared with the prior art, the utility model provides a liquid chromatography separation column possesses following beneficial effect:
1. this liquid chromatography separation column blocks the screw ring through the bulge loop for the screw ring is screwed up on the screw thread post, is in the same place cylinder and screw thread column connection, and it is more stable more convenient to connect, when screwing up the screw ring on the screw thread post, and the screw ring extrusion annular gasbag admits air in making the annular seal gasbag, fills the gap after cylinder and screw thread post are hugged closely, improves the leakproofness and prevents gas leakage, and then prevents to produce the weeping phenomenon under the high pressure.
2. This liquid chromatography separation post, through cylinder and threaded column connection back, the reference column injects in the constant head tank on the threaded column, and the reference column sets up for the symmetry, can prevent that the cylinder from rotating on the threaded column, can further prevent simultaneously that the cylinder from rocking on the threaded column, and then avoids the cylinder to rock and leads to the gap increase between cylinder and the threaded column and take place the weeping problem.
The part which is not involved in the device is the same as the prior art or can be realized by adopting the prior art, the utility model discloses a screw thread ring screw thread is screwed up on the screw thread post, and the screw thread ring extrudes the annular gasbag to make the annular sealed gasbag and the spout admit air, and the annular sealed gasbag is clung to the screw thread post terminal surface, fills the gap between cylinder and the screw thread post, improves the leakproofness, prevents to appear the weeping; the gas that enters into in the spout simultaneously promotes the stopper and enters into the spacing groove, with the reference column chucking on the screw post for the cylinder installation is firm, avoids rocking, prevents the gap increase between cylinder and the screw post, and further improvement leakproofness prevents to leak gas, and then prevents to produce the weeping under high-pressure operational environment.
Drawings
Fig. 1 is a schematic structural diagram of a liquid chromatography separation column according to the present invention;
fig. 2 is a schematic view of a partial structure of a liquid chromatography separation column according to the present invention;
fig. 3 is a schematic structural diagram of a in fig. 2 of a liquid chromatography separation column according to the present invention.
In the figure: 1. a cylinder; 10. a convex ring; 11. a threaded ring; 13. an annular air bag; 14. an annular sealing air bag; 15. a connecting pipe; 16. a receiving groove; 21. a threaded post; 22. positioning a groove; 23. a limiting groove; 3. a positioning column; 31. a chute; 32. a tension spring; 33. a limiting block; 34. the trachea.
Detailed Description
The technical solutions in the embodiments of the present invention will be described clearly and completely with reference to the accompanying drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only some embodiments of the present invention, not all embodiments.
In the description of the present invention, it is to be understood that the terms "upper", "lower", "front", "rear", "left", "right", "top", "bottom", "inner", "outer", and the like indicate orientations or positional relationships based on the orientations or positional relationships shown in the drawings, and are only for convenience of description and simplicity of description, and do not indicate or imply that the device or element being referred to must have a particular orientation, be constructed and operated in a particular orientation, and therefore, should not be construed as limiting the present invention.
Example 1:
referring to fig. 1 to 3, a liquid chromatography separation column includes a column body 1, and further includes: a threaded ring 11 connected to the cylinder 1 in a sliding and rotating manner; the convex rings 10 are fixedly connected to two ends of the column body 1 and used for limiting the threaded ring 11; an annular air bag 13 fixedly connected to the inner side of the convex ring 10 close to the threaded ring 11; the threaded column 21 is locked on the threaded column 21 in a rotating mode, the end face of the column body 1 is fixedly connected with an annular sealing air bag 14, the annular sealing air bag 14 is attached to the end face, close to the column body 1, of the threaded column 21, and the annular sealing air bag 14 is communicated with the annular air bag 13 through a connecting pipe 15; the positioning column 3 is fixedly connected to the end face of the column body 1, the threaded column 21 is provided with a positioning groove 22, the positioning column 3 corresponds to the positioning groove 22, sliding grooves 31 are formed in two sides of the positioning column 3, a limiting block 33 is connected in the sliding groove 31 in a sliding manner, a tension spring 32 is fixedly connected between the limiting block 33 and the sliding groove 31, limiting grooves 23 are formed in two sides of the positioning groove 22, the limiting block 33 corresponds to the limiting grooves 23, and the sliding groove 31 is communicated with the annular air bag 13 through an air pipe 34; the threaded ring 11 is in threaded connection with the threaded column 21; the positioning columns 3 are symmetrically arranged; the positioning column 3 is positioned at the eccentric position of the column body 1; the positioning column 3 and the positioning groove 22 are symmetrically arranged;
when in use, the two positioning columns 3 on the column body 1 are inserted into the positioning grooves 22 corresponding to the positioning columns 3, after the positioning columns 3 are inserted into the positioning grooves 22, the limiting blocks 33 are opposite to the limiting grooves 23, then the threaded rings 11 are pulled to be close to the corresponding threaded columns 21, and the threaded rings 11 are rotated to screw the threaded rings 11 on the threaded columns 21;
it should be understood that the outer diameter of the threaded column 21 is threaded, and the inner diameter of the threaded ring 11 is threaded; the threaded ring 11 is affected by the convex ring 10 and cannot fall off from the column body 1;
when the threaded ring 11 is screwed down, the threaded ring 11 extrudes the annular air bag 13, and after the annular air bag 13 is extruded, the internal gas enters the annular sealing air bag 14 through the connecting pipe 15 and enters the chute 31 through the air pipe 34;
after the annular sealing air bag 14 is tightly attached to the end face of the threaded column 21, the gas extruded in the annular air bag 13 enters the sliding groove 31, the gas pressure in the sliding groove 31 is increased, the tension spring 32 is pushed to extend, the limiting block 33 enters the limiting groove 23, the positioning column 3 is tightly clamped on the threaded column 21, the column body 1 is prevented from shaking after being installed on the threaded column 21, the gap between the column body 1 and the threaded column 21 is prevented from being increased, and the sealing performance is further improved;
it is understood that the annular air bag 13 is annular, is sleeved on the column body 1 and is fixed on the convex ring 10; the two ends of the column body 1 have the same structure and are connected through the connecting structure, which is not described in detail herein.
Example 2:
referring to fig. 2, a liquid chromatography separation column, substantially the same as in example 1, further comprising: the end face of the column body 1 is provided with a containing groove 16, and the annular sealing air bag 14 is fixedly connected in the containing groove 16;
the annular air-tight bag 14 is positioned in the accommodating groove 16, so that the contact area of the column body 1 and the threaded column 21 is constant, and the annular air-tight bag 14 can effectively fill the gap between the threaded column 21 and the column body 1.
The utility model has the advantages that after the threaded ring 11 is screwed on the threaded column 21, the threaded ring 11 extrudes the annular air bag 13 to enable the annular sealing air bag 14 to enter the air in the chute 31, the annular sealing air bag 14 is tightly attached to the end surface of the threaded column 21, and the gap between the column body 1 and the threaded column 21 is filled, so that the sealing performance is improved, and liquid leakage is prevented; the gaseous stopper 33 that promotes that enters into in the spout 31 simultaneously enters into spacing groove 23, with reference column 3 chucking on threaded column 21 for cylinder 1 installation is firm, avoids rocking, prevents the gap increase between cylinder 1 and the threaded column 21, and further improvement leakproofness prevents to leak gas, and then prevents to produce the weeping under high pressure operational environment.
The above, only be the concrete implementation of the preferred embodiment of the present invention, but the protection scope of the present invention is not limited thereto, and any person skilled in the art is in the technical scope of the present invention, according to the technical solution of the present invention and the utility model, the concept of which is equivalent to replace or change, should be covered within the protection scope of the present invention.
Claims (6)
1. A liquid chromatography separation column comprising a column body (1), characterized by further comprising:
a threaded ring (11) slidably connected to the cylinder (1);
the convex rings (10) are fixedly connected to the two ends of the column body (1) and used for limiting the threaded ring (11);
the annular air bag (13) is fixedly connected to the inner side, close to the threaded ring (11), of the convex ring (10);
a threaded column (21),
the threaded ring (11) is rotationally locked on the threaded column (21), an annular sealing air bag (14) is fixedly connected to the end face of the column body (1), the annular sealing air bag (14) is attached to the end face, close to the column body (1), of the threaded column (21), and the annular sealing air bag (14) is communicated with the annular air bag (13) through a connecting pipe (15);
fixed connection is in reference column (3) of cylinder (1) terminal surface, constant head tank (22) have been seted up on screw thread post (21), reference column (3) are corresponding with constant head tank (22), spout (31) have all been seted up to reference column (3) both sides, sliding connection has stopper (33) in spout (31), fixedly connected with extension spring (32) between stopper (33) and spout (31), spacing groove (23) have all been seted up to constant head tank (22) both sides, stopper (33) are corresponding with spacing groove (23), be linked together through trachea (34) between spout (31) and annular gasbag (13).
2. A liquid chromatography separation column according to claim 1, wherein the threaded ring (11) is threaded onto a threaded column (21).
3. The liquid chromatography separation column according to claim 1, wherein the end face of the column body (1) is provided with a receiving groove (16), and the annular sealing air bag (14) is fixedly connected in the receiving groove (16).
4. A liquid chromatography separation column according to claim 1, characterized in that the positioning columns (3) are symmetrically arranged.
5. A liquid chromatography separation column according to claim 1, characterized in that the positioning column (3) is located off-centre of the column body (1).
6. A liquid chromatography separation column according to claim 1, characterized in that the positioning column (3) and the positioning groove (22) are symmetrically arranged.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202220411425.1U CN216824925U (en) | 2022-02-28 | 2022-02-28 | Liquid chromatography separation column |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202220411425.1U CN216824925U (en) | 2022-02-28 | 2022-02-28 | Liquid chromatography separation column |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN216824925U true CN216824925U (en) | 2022-06-28 |
Family
ID=82092996
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202220411425.1U Active CN216824925U (en) | 2022-02-28 | 2022-02-28 | Liquid chromatography separation column |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN216824925U (en) |
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2022
- 2022-02-28 CN CN202220411425.1U patent/CN216824925U/en active Active
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