CN216646537U

CN216646537U - Sample analyzer

Info

Publication number: CN216646537U
Application number: CN202122942876.6U
Authority: CN
Inventors: 贾腾; 张少维; 冯亚辉
Original assignee: Shenzhen Mindray Bio Medical Electronics Co Ltd
Current assignee: Shenzhen Mindray Bio Medical Electronics Co Ltd
Priority date: 2021-11-26
Filing date: 2021-11-26
Publication date: 2022-05-31
Anticipated expiration: 2031-11-26

Abstract

The application discloses a sample analysis device. The sample analyzer includes a sample unit, a reagent unit, a cuvette, a measurement unit, and a cleaning unit. The sample part dispenses a sample to be tested. The reagent unit dispenses a reagent. The reaction cup carries a sample, or a reagent, or a reaction solution in which the sample and the reagent are mixed. The measuring unit performs a test of the reaction solution. The cleaning component comprises a liquid injection pipeline, a liquid injection switch valve and a branch pipeline, the liquid injection switch valve is installed in the liquid injection pipeline, and the part of the liquid injection pipeline, which is connected with the liquid inlet end of the liquid injection switch valve, is communicated with the branch pipeline. The liquid injection pipeline and the branch pipeline are filled with cleaning liquid, even if the flow rate of the cleaning liquid is increased, a part of the cleaning liquid flows out of the branch pipeline before the liquid injection switch valve is opened so as to release the fluid pressure in the liquid injection pipeline and eliminate the negative water hammer effect of the liquid injection pipeline, and after the liquid injection switch valve is opened, the cleaning liquid is conveyed into the reaction cup by the liquid injection pipeline, so that the cleaning liquid in the reaction cup can be prevented from splashing, and the cup mouth of the reaction cup is prevented from crystallizing.

Description

Sample analyzer

Technical Field

The utility model relates to the technical field of medical instruments, in particular to a sample analysis device.

Background

In the medical industry, sample analysis devices are one of the most commonly used important analytical instruments. The reaction cup for loading the sample in the sample analysis device is a reusable device, and the reaction cup needs to be cleaned and reused after one test analysis is completed. The cleaning process of the reaction cup comprises the steps of firstly sucking away the residual liquid in the reaction cup and then injecting cleaning liquid into the reaction cup. Because the cleaning effect of the reaction cup is strongly related to the liquid injection amount of the cleaning liquid, in order to ensure that the liquid injection amount of the cleaning liquid in a short time meets the requirement, the flow rate of the cleaning liquid is increased, but the increase of the flow rate can cause the liquid pressure in the liquid injection pipeline to rise at the moment of opening the switch valve during liquid injection, so that the cleaning liquid in the reaction cup splashes, exceeds the cleaning height, even reaches the cup mouth of the reaction cup, and the cup mouth of the reaction cup is crystallized due to long-term accumulation.

SUMMERY OF THE UTILITY MODEL

The application provides a sample analysis device to solve the problem that sample analysis device of prior art leads to the washing liquid in the reaction cup to produce and spatters the liquid through the velocity of flow that increases the washing liquid.

In one aspect, the present application provides a sample analysis device comprising: a sample part, a reagent part, a reaction cup, a measuring part and a cleaning part;

the sample component is used for dispensing a sample to be tested;

the reagent component is used for dispensing a reagent;

the reaction cup is used for bearing a sample, a reagent or a reaction liquid mixed by the sample and the reagent;

the measuring part is used for carrying out project test on the reaction liquid;

the cleaning component comprises a liquid injection pipeline, a liquid injection switch valve and a branch pipeline;

the liquid injection switch valve is arranged in the liquid injection pipeline; the part of the liquid injection pipeline, which is connected with the liquid inlet end of the liquid injection switch valve, is communicated with the branch pipeline;

the liquid injection pipeline and the branch pipeline are used for introducing cleaning liquid; and the liquid injection pipeline is used for conveying the cleaning liquid to the reaction cup after the liquid injection switch valve is opened.

In some possible implementation manners, the cleaning component further includes a branch switch valve installed in the branch pipeline, and a portion of the liquid injection pipeline, which is connected to the liquid inlet end of the liquid injection switch valve, is communicated with a portion of the branch pipeline, which is connected to the liquid inlet end of the branch switch valve.

In some possible implementations, the sample analysis device further includes a control unit connected to the priming on-off valve and the branch on-off valve;

the control unit is used for controlling the branch switch valve and the liquid injection switch valve to be opened simultaneously, or controlling the branch switch valve to be opened within preset opening time before the liquid injection switch valve is opened, and controlling the branch switch valve to be closed within preset closing time after the liquid injection switch valve is opened.

In some possible implementations, the cleaning component further includes a branch component installed in the liquid injection pipeline, and the branch component divides the liquid injection pipeline into a liquid injection main path and at least two liquid injection branch paths;

the liquid injection switch valve is installed in the liquid injection main path to serve as a main path switch valve.

In some possible implementations, a ratio of a path of the branch switching valve to a path of the main path switching valve is 0.9 to 1.3, and/or a ratio of a pipe diameter of the branch pipe to a pipe diameter of the main liquid injection path is 0.9 to 1.3.

In some possible implementation manners, the number of the liquid injection switch valves is at least two, the liquid injection switch valves are installed in at least two liquid injection branches, and the liquid injection switch valves installed in the liquid injection branches are used as branch switch valves;

the drift diameter of the branch switch valve is smaller than the sum of the drift diameters of all the shunt switch valves, and/or the pipe diameter of the branch pipeline is smaller than the sum of the pipe diameters of all the liquid injection shunts.

the number of the liquid injection switch valves is at least two, the liquid injection switch valves are installed in at least two liquid injection branches, and the liquid injection switch valves installed in the liquid injection branches are used as branch switch valves;

In some possible implementations, a ratio of the bypass opening/closing valve to a sum of the bypass openings of all the shunt opening/closing valves is 3: 16 to 3: 8, and/or the ratio of the pipe diameter of the branch pipeline to the sum of all the pipe diameters of the liquid injection branches is 3: 16 to 3: 8.

in some possible implementations, a ratio of the bypass opening/closing valve to a sum of the bypass openings of all the shunt opening/closing valves is 7: 32 to 9: 32, and/or the ratio of the pipe diameter of the branch pipeline to the sum of the pipe diameters of all the liquid injection branches is 7: 32 to 9: 32.

in some possible implementation manners, the cleaning component further comprises a liquid storage tank for storing cleaning liquid, the liquid injection pipeline is connected with the liquid inlet end of the liquid injection switch valve and communicated with the liquid storage tank, and the branch pipeline is connected with the liquid outlet end of the branch switch valve and communicated with the liquid storage tank.

In some possible implementations, the cleaning component further includes a diversion block installed in the liquid injection pipe, and the branch pipe is connected to the diversion block.

In some possible implementations, the cleaning component further includes a pressure sensor connected to the diverter block.

In some possible implementations, the cleaning component further includes a heater installed in the liquid injection pipeline and located between the flow dividing block and the liquid injection switch valve.

In some possible implementations, the cleaning solution is deionized water.

In some possible implementation manners, the cleaning component further comprises a liquid injection needle connected with the liquid outlet end of the liquid injection pipeline, and a liquid suction needle connected with the liquid injection needle;

the upper end of the liquid injection needle close to the liquid injection pipeline and the liquid suction needle are obliquely arranged.

The sample analyzer includes a sample unit, a reagent unit, a cuvette, a measurement unit, and a cleaning unit. The sample part is used for dispensing a sample to be tested. The reagent unit is used for dispensing a reagent. The reaction cup is used for bearing a sample, or a reagent, or a reaction liquid for mixing the sample and the reagent. The measuring unit is used for performing a project test on the reaction solution. The cleaning component comprises a liquid injection pipeline, a liquid injection switch valve and a branch pipeline, the liquid injection switch valve is installed in the liquid injection pipeline, and the part of the liquid injection pipeline, which is connected with the liquid inlet end of the liquid injection switch valve, is communicated with the branch pipeline. The liquid injection pipeline and the branch pipeline can be filled with cleaning liquid, even if the flow rate of the cleaning liquid is increased, a part of the cleaning liquid can flow out of the branch pipeline before the liquid injection switch valve is opened so as to release the fluid pressure in the liquid injection pipeline and eliminate the negative water hammer effect of the liquid injection pipeline, after the liquid injection switch valve is opened, the cleaning liquid is conveyed into the reaction cup by the liquid injection pipeline, so that the cleaning liquid conveyed into the reaction cup can be prevented from splashing, and further the cup mouth of the reaction cup is prevented from crystallizing.

Drawings

In order to more clearly illustrate the technical solutions in the embodiments of the present invention, the drawings needed to be used in the description of the embodiments will be briefly introduced below, and it is obvious that the drawings in the following description are only some embodiments of the present invention, and it is obvious for those skilled in the art to obtain other drawings based on these drawings without creative efforts.

FIG. 1 is a block diagram of a sample analysis device according to an embodiment of the present application;

FIG. 2 is a schematic view of a sample analysis device provided in an embodiment of the present application;

FIG. 3 is a schematic view of a cleaning component of a sample analysis device provided in an embodiment of the present application;

FIG. 4 is a schematic view of a cleaning component of a sample analysis device provided in another embodiment of the present application;

FIG. 5 is a schematic view of a cleaning component of a sample analysis device according to yet another embodiment of the present application.

Detailed Description

The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.

In the description of the present invention, it is to be understood that the terms "center", "longitudinal", "lateral", "length", "width", "thickness", "upper", "lower", "front", "rear", "left", "right", "vertical", "horizontal", "top", "bottom", "inner", "outer", etc. indicate orientations or positional relationships based on those shown in the drawings, and are only for convenience of description and simplicity of description, but do not indicate or imply that the device or element being referred to must have a particular orientation, be constructed and operated in a particular orientation, and thus, should not be considered as limiting the present invention. Furthermore, the terms "first", "second" and "first" are used for descriptive purposes only and are not to be construed as indicating or implying relative importance or implicitly indicating the number of technical features indicated. Thus, features defined as "first", "second", may explicitly or implicitly include one or more of the described features. In the description of the present invention, "a plurality" means two or more unless specifically defined otherwise.

In the description of the present application, it is to be noted that, unless otherwise explicitly specified or limited, the terms "mounted," "connected," and "connected" are to be construed broadly, e.g., as meaning either a fixed connection, a removable connection, or an integral connection; may be mechanically connected, may be electrically connected or may be in communication with each other; either directly or indirectly through intervening media, either internally or in any other relationship. The specific meaning of the above terms in the present application can be understood by those of ordinary skill in the art as appropriate.

Referring to fig. 1 to 5, in an embodiment of the present application, a sample analyzer includes: a sample part 1, a reagent part 2, a reaction cup 3, a measuring part 4 and a cleaning part 5;

the sample component 1 is used for dispensing a sample to be tested;

the reagent unit 2 is used for dispensing a reagent;

the reaction cup 3 is used for bearing a sample, a reagent or a reaction liquid for mixing the sample and the reagent;

the measuring unit 4 is used for performing a project test on the reaction solution;

the cleaning component 5 comprises a liquid injection pipeline 51, a liquid injection switch valve 52 and a branch pipeline 53;

a liquid injection switch valve 52 is installed in the liquid injection pipe 51; the part of the liquid injection pipeline 51 connected with the liquid inlet end of the liquid injection switch valve 52 is communicated with a branch pipeline 53;

the liquid injection pipeline 51 and the branch pipeline 53 are used for introducing cleaning liquid; the liquid injection pipe 51 is used for delivering the cleaning liquid into the reaction cup 3 after the liquid injection switch valve 52 is opened.

After the measurement unit 4 performs the item test on the reaction solution, the cuvette 3 needs to be cleaned, and in order to clean the cuvette 3 in a short time, the flow rate of the cleaning solution is increased, that is, the power of the power pump 54 is increased, and the power pump 54 is installed in the liquid injection pipe 51. If the branch pipe 53 is not provided to communicate with the liquid inlet end of the liquid injection pipe 51 connected to the liquid injection switch valve 52, after the liquid injection switch valve 52 is closed, the cleaning liquid in the liquid injection pipe 51 cannot flow, the power of the power pump 54 is increased to increase the fluid pressure in the liquid injection pipe 51, and after the closed liquid injection switch valve 52 is suddenly opened, the cleaning liquid in the liquid injection pipe 51 is violently accelerated under the action of inertia, so that the cleaning liquid is quickly conveyed to the reaction cup 3 to generate splashing. The phenomenon that the cleaning liquid in the liquid injection pipe 51 is accelerated violently by inertia after the liquid injection on-off valve 52 is opened suddenly is also called negative water hammer effect.

This application is connected the part intercommunication of annotating liquid ooff valve 52 feed liquor end through setting up branch pipeline 53 and notes liquid pipeline 51, before wasing reaction cup 3, that is to say after annotating liquid ooff valve 52 and closing, because annotate liquid pipeline 51 and branch pipeline 53 and all can let in the washing liquid, so partly washing liquid can flow from branch pipeline 53, the washing liquid in annotating liquid pipeline 51 in other words also can flow, with the fluid pressure in the liquid pipeline 51 is annotated in the release, eliminate the negative water hammer effect of annotating liquid pipeline 51, annotate liquid ooff valve 52 that will close and open the back suddenly, the washing liquid in annotating liquid pipeline 51 can not violently accelerate, thereby can avoid carrying the washing liquid production in reaction cup 3 to spatter the liquid, and then avoid reaction cup 3 rim of a cup crystallization.

In some embodiments, the cleaning solution is deionized water, which has a good cleaning effect on the reaction cup 3 and is low in cost. But do not have chemical reagent in the deionized water, breed the microorganism easily and lead to the crystallization, promptly, produce when deionized water in reaction cup 3 and spatter the liquid the rim of a cup that can stop at reaction cup 3, and lead to reaction cup 3 rim of a cup crystallization, consequently, this application is connected the part intercommunication of annotating liquid switch valve 52 feed liquor end through setting up branch pipeline 53 and notes liquid pipeline 51, with the fluid pressure in the release notes liquid pipeline 51, eliminate the negative water hammer effect of annotating liquid pipeline 51, can avoid carrying the washing liquid production of reaction cup 3 in to spattering the liquid, and then avoid reaction cup 3 rim of a cup crystallization.

In some embodiments, the sample unit 1 is used for dispensing a sample to be tested, which means that the sample unit 1 can carry the sample to be tested, and the sample is provided to the determination unit 4 after being sucked. Referring to fig. 1 and 2, the sample unit 1 may include a sample carrier 11 and a sample dispensing mechanism 12. The sample carrier 11 is used to carry a sample. Some examples of the Sample carrier 11 may include a Sample Delivery Module (SDM) and a front end rail; in other examples, such as the example shown in fig. 2, the sample carrier 11 may also be a sample tray, the sample tray includes a plurality of sample sites for placing samples, such as sample tubes, and the sample tray can dispatch the samples to corresponding positions, such as positions for the sample dispensing mechanism 12 to suck the samples, by rotating the tray structure. The sample dispensing mechanism 12 is used for sucking a sample and discharging the sample into the reaction cup 3 to be loaded, so as to dispense the sample to be tested. For example, the sample dispensing mechanism 12 may include a sample needle that performs a two-dimensional or three-dimensional motion in space by a two-dimensional or three-dimensional driving mechanism, so that the sample needle can be moved to aspirate a sample carried by the sample carrying member 11, and to the cuvette 3 to be loaded, and discharge the sample to the cuvette 3.

The reagent unit 2 is used for dispensing a reagent, and means that the reagent unit 2 can carry a reagent, aspirate the reagent, and supply the reagent to the measurement unit 4. The reagent component 2 may in some embodiments comprise a reagent carrier component 21 and a reagent dispensing mechanism 22. The reagent bearing member 21 is for bearing a reagent. In one embodiment, the reagent carrier 21 may be a reagent disk, the reagent disk is configured in a disk-shaped structure and has a plurality of positions for carrying reagent containers, and the reagent carrier 21 can rotate and drive the reagent containers carried by the reagent carrier to rotate to a specific position, for example, a position for sucking reagent by the reagent dispensing mechanism 22. The number of the reagent carrying member 21 may be one or more. The reagent dispensing mechanism 22 is used to suck a reagent and discharge the reagent into the cuvette 3 to which the reagent is to be added. In one embodiment, the reagent dispensing mechanism 22 may include a reagent needle that performs a two-dimensional or three-dimensional motion in space by a two-dimensional or three-dimensional driving mechanism, so that the reagent needle can move to aspirate a reagent carried by the reagent carrying member 21 and to the cuvette 3 to be loaded with the reagent, and discharge the reagent to the cuvette 3.

The measuring unit 4 is used for performing a test on the reaction solution to obtain test data of the item. The measurement component 4 may in some embodiments comprise a reaction component 41 and a photometric component 42. The reaction part 41 has at least one placing position for placing the cuvette 3 and incubating the reaction liquid in the cuvette 3. For example, the reaction part 41 may be a reaction disc, which is arranged in a disc-shaped structure and has one or more placing positions for placing the reaction cups 3, and the reaction disc can rotate and drive the reaction cups 3 in the placing positions to rotate, so as to schedule the reaction cups 3 in the reaction disc and incubate the reaction solution in the reaction cups 3. The photometric device 42 is used to perform photometric measurement on the incubated reaction solution to obtain reaction data of the sample. For example, the photodetector 42 detects the light emission intensity of the reaction solution to be measured, and calculates the concentration of the component to be measured in the sample from the calibration curve. In one embodiment, the photometric component 42 is separately disposed outside the reaction component 41.

In some embodiments, referring to fig. 3 to 5, the cleaning component 5 further includes a branch switch valve 531 installed in the branch pipe 53, and a portion of the liquid injection pipe 51 connected to the liquid inlet end of the liquid injection switch valve 52 is communicated with a portion of the branch pipe 53 connected to the liquid inlet end of the branch switch valve 531.

That is, when the reaction cup 3 is to be cleaned, the branch switch valve 531 and the filling switch valve 52 may be opened simultaneously, and the branch switch valve 531 may also be opened before the filling switch valve 52 is opened, so that a part of the cleaning liquid can flow out from the branch pipe 53 to release the fluid pressure in the filling pipe 51, and the negative water hammer effect of the filling pipe 51 is eliminated, thereby preventing the cleaning liquid delivered to the reaction cup 3 from splashing. Furthermore, the branch switch valve 531 may be closed after the filling switch valve 52 is opened, so as to stop a portion of the cleaning liquid from flowing out of the branch pipe 53, thereby avoiding excessively reducing the flow rate of the cleaning liquid in the filling pipe 51, and thus avoiding reducing the flow rate of the cleaning liquid in the filling pipe 51, so as to ensure that the amount of the cleaning liquid filled into the reaction cup 3 in a short time (e.g., a cleaning period of 3.6 seconds) satisfies a preset capacity.

In this embodiment, please refer to fig. 1, the sample analyzer further includes a control unit 6 connected to the injection switch valve 52 and the branch switch valve 531, wherein the control unit 6 is configured to control the branch switch valve 531 and the injection switch valve 52 to be simultaneously opened, or control the branch switch valve 531 to be opened within a preset opening time before the injection switch valve 52 is opened, and control the branch switch valve 531 to be closed within a preset closing time after the injection switch valve 52 is opened.

That is, the control unit 6 controls the branch switch valve 531 to open within a preset opening time before the liquid injection switch valve 52 opens, which may be 0.05 second to 0.4 second, for example, 0.1 second, so that not only the fluid pressure in the liquid injection pipeline 51 can be released, the negative water hammer effect of the liquid injection pipeline 51 can be eliminated, the liquid splashing of the cleaning liquid in the reaction cup 3 can be prevented, but also excessive cleaning liquid can be prevented from flowing out from the branch pipeline 53, so as to save the cleaning liquid. And the control unit 6 controls the branch switch valve 531 to close within a preset closing time after the liquid injection switch valve 52 is opened, which may be 0.05 to 0.4 seconds, for example, 0.1 second, so as to avoid excessive cleaning liquid from flowing out of the branch pipe 53, avoid excessively reducing the flow of the cleaning liquid in the liquid injection pipe 51, further avoid reducing the flow rate of the cleaning liquid in the liquid injection pipe 51, and ensure that the amount of the cleaning liquid injected into the reaction cup 3 in a short time meets a preset capacity, so as to ensure the cleaning effect of the reaction cup 3.

In this embodiment, under the condition that the cleaning cycle of the reaction cup 3 is not changed, the flow rate of the cleaning liquid in the liquid injection pipeline 51 is in a positive correlation with the size of the reaction cup 3, so as to ensure that the cleaning of the reaction cup 3 can be completed in the cleaning cycle for the reaction cups 3 with different sizes. For example, when the area of the bottom of the reaction cup 3 is 4mm by 5mm and the height is 30mm, the flow rate of the washing solution may be 50ml/min to 80 ml/min.

In this embodiment, the control unit 6 may also connect the sample part 1, the reagent part 2, and the assay part 4 to control the operations of the sample part 1, the reagent part 2, and the assay part 4. The control Unit 6 may be a Central Processing Unit (CPU), other general purpose Processor, a Digital Signal Processor (DSP), an Application Specific Integrated Circuit (ASIC), an off-the-shelf Programmable Gate Array (FPGA) or other Programmable logic device, discrete Gate or transistor logic device, discrete hardware component, etc.

In some embodiments, the charge switch valve 52 and the branch switch valve 531 may be solenoid valves or pneumatic valves. Of course, the filling switch valve 52 and the branch switch valve 531 may be other types of valves, and the present application is not limited thereto.

In some embodiments, referring to fig. 3, the cleaning component 5 further includes a branch component 55 installed in the liquid injection pipeline 51, and the branch component 55 divides the liquid injection pipeline 51 into a main liquid injection path 511 and at least two branch liquid injection paths 512. The filling switching valve 52 is installed in the filling main path 511 as a main path switching valve. That is to say, the at least two liquid injection branches 512 can deliver the cleaning liquid to the at least two reaction cups 3 respectively, and the main-way switching valve can control whether the cleaning liquid is introduced into the at least two liquid injection branches 512 at the same time, so as to clean the at least two reaction cups 3 at the same time, thereby improving the cleaning efficiency.

In this embodiment, the ratio of the main path of the branch switch valve 531 to the main path of the main path switch valve is 0.9 to 1.3, and/or the ratio of the pipe diameter of the branch pipe 53 to the pipe diameter of the main injection pipe 511 is 0.9 to 1.3, so that it can be ensured that the flow rate of the cleaning liquid in the branch pipe 53 can release the fluid pressure in the injection pipe 51 after the branch switch valve 531 is opened, thereby eliminating the negative water hammer effect of the injection pipe 51, preventing the cleaning liquid in the reaction cup 3 from splashing, and preventing excessive cleaning liquid from flowing out from the branch pipe 53, so as to save the cleaning liquid, and at the same time, it can be avoided that the flow rate of the cleaning liquid in the injection pipe 51 is excessively reduced, thereby ensuring that the cleaning liquid amount injected into the reaction cup 3 in a short time meets a preset capacity, so as to ensure the cleaning effect of the reaction cup 3.

In this embodiment, the flow splitting part 55 includes at least one flow splitting connector 551, the flow splitting connector 551 has one inflow nozzle and at least two outflow nozzles, the number of the flow splitting connectors 551 and the number of the outflow nozzles in the flow splitting connector 551 can be specifically selected according to the number of the liquid injection branches 512, and the application is not limited herein.

For example, when the number of the liquid injection branches 512 is two, the number of the branch joints 551 is one, and the number of the outflow nozzles in the branch joints 551 is two, the inflow nozzle of the branch joint 551 is connected to the liquid injection main passage 511, and the two outflow nozzles of the branch joint 551 are connected to the two liquid injection branches 512, respectively.

For another example, when the number of the liquid injection branches 512 is four, the number of the branch joints 551 is one, and the number of the outflow nozzles in the branch joints 551 is four, the inflow nozzle of the branch joint 551 is connected to the liquid injection main passage 511, and the four outflow nozzles of the branch joint 551 are connected to the four liquid injection branches 512, respectively.

For another example, when the number of the liquid injection branches 512 is four, the number of the branch joints 551 is three, and the number of the outflow nozzles in the branch joint 551 is two, the branch part 55 further includes two branch pipes 552, the inflow nozzle of the first branch joint 551 is connected to the liquid injection main branch 511, the two outflow nozzles of the first branch joint 551 are respectively connected to one ends of the two branch pipes 552, the other ends of the two branch pipes 552 are respectively connected to the inflow nozzles of the second and third branch joints 551, and a total of four outflow nozzles in the second and third branch joints 551 are respectively connected to the four liquid injection branches 512.

For example, when the number of the liquid injection branches 512 is eight, the number of the branch joints 551 is one, and the number of the outflow nozzles in the branch joints 551 is eight, the inflow nozzle of the branch joint 551 is connected to the main liquid injection branch 511, and the eight outflow nozzles of the branch joint 551 are connected to the eight liquid injection branches 512, respectively.

For another example, when the number of the liquid injection branches 512 is eight, the number of the branching joints 551 is seven, the number of the outflow nozzles in the branching joints 551 is two, the flow splitting part 55 further comprises six flow splitting pipes 552, the inlet nozzle of the first flow splitting joint 551 is connected to the main liquid injection pipe 511, two outlet nozzles of the first flow splitting joint 551 are respectively connected to one ends of the first and second first flow splitting pipes 552, the other ends of the first and second first flow splitting pipes 552 are respectively connected to the inlet nozzles of the second and third flow splitting joints 551, a total of four outlet nozzles of the second and third flow splitting joints 551 are respectively connected to one ends of the third to sixth second flow splitting pipes 552, the other ends of the third to sixth second flow splitting pipes 552 are respectively connected to the inlet nozzles of the fourth to seventh flow splitting joints 551, and a total of eight outlet nozzles of the fourth to seventh flow splitting joints 551 are respectively connected to the eight liquid injection branches 512.

In addition, in order to ensure the flow rate of the cleaning liquid in the at least two liquid injection branches 512, the pipe diameters of the at least two liquid injection branches 512 are required to be smaller than the pipe diameter of the main liquid injection branch 511, and the flow dividing part 55 further comprises at least one large-small turning joint 553, wherein the large-small turning joint 553 is provided with an inflow pipe nozzle with a larger pipe diameter and an outflow pipe nozzle with a smaller pipe diameter, and the large-small turning joint 553 is arranged in the flow dividing pipeline 552 or the liquid injection branch 512 so as to be matched with the liquid injection branch 512 with a smaller pipe diameter.

In this embodiment, referring to fig. 4, the number of the liquid injection switch valves 52 is at least two, the liquid injection switch valves 52 are installed in at least two liquid injection branches 512, the liquid injection switch valves 52 installed in the liquid injection branches 512 are used as branch switch valves, the drift diameter of the branch switch valve 531 is smaller than the sum of the drift diameters of all the branch switch valves, and/or the pipe diameter of the branch pipe 53 is smaller than the sum of the pipe diameters of all the liquid injection branches 512.

That is to say, the liquid injection main circuit 511 and the liquid injection branch circuit 512 can be provided with the liquid injection switch valve 52, and when the main circuit switch valve and the branch switch valve are both opened, the liquid injection branch circuit 512 can deliver the cleaning liquid to the reaction cup 3, so as to avoid mistakenly cleaning the reaction cup 3. Through making the latus rectum of branch switch valve 531 be less than the latus rectum sum of whole shunt switch valve, and/or, the pipe diameter of branch pipe 53 is less than the pipe diameter sum of whole notes liquid shunt 512, can open simultaneously at main way switch valve and a plurality of shunt switch valves, when making a plurality of notes liquid shunt 512 carry the washing liquid simultaneously and wash a plurality of reaction cups 3, avoid too much washing liquid to flow out from branch pipe 53, in order to practice thrift the washing liquid, can also avoid excessively reducing the flow of the washing liquid in a plurality of notes liquid shunt 512 simultaneously, thereby avoid reducing the velocity of flow of the washing liquid in a plurality of notes liquid shunt 512, guarantee that the washing liquid volume that a plurality of reaction cups 3 injected in the short time satisfies preset capacity, in order to guarantee the cleaning performance of a plurality of reaction cups 3.

In this embodiment, the ratio of the diameter of the branch switching valve 531 to the sum of the diameters of all the shunt switching valves may be 3: 16 to 3: 8, and/or the ratio of the pipe diameter of the branch pipe 53 to the sum of the pipe diameters of all the injection branches 512 can be 3: 16 to 3: 8, can guarantee that the flow of the washing liquid in the branch pipe 53 can release a plurality of fluid pressure of annotating in the liquid branch 512, thereby eliminate a plurality of negative water hammer effect of annotating the liquid branch 512, prevent that the washing liquid in the reaction cup 3 from producing the splash liquid, and can also avoid excessively reducing the flow of a plurality of washing liquids of annotating in the liquid branch 512, thereby avoid reducing the flow rate of a plurality of washing liquids of annotating in the liquid branch 512, guarantee that the washing liquid volume that a plurality of reaction cups 3 injected in the short time satisfies preset capacity, in order to guarantee the cleaning performance of a plurality of reaction cups 3.

Further, the ratio of the sum of the diameters of the branch switching valves 531 and the diameters of all the shunt switching valves may be 7: 32 to 9: 32, and/or the ratio of the pipe diameter of the branch pipe 53 to the sum of the pipe diameters of all the injection branches 512 can be 7: 32 to 9: 32, can further guarantee that the flow of the washing liquid in the branch pipeline 53 can release a plurality of fluid pressure of annotating in the liquid branch 512, thereby eliminate a plurality of negative water hammer effect of annotating the liquid branch 512, prevent that the washing liquid in the reaction cup 3 from producing the splash liquid, and can also avoid excessively reducing the flow of a plurality of washing liquids of annotating in the liquid branch 512, thereby avoid reducing the velocity of flow of a plurality of washing liquids of annotating in the liquid branch 512, guarantee that the washing liquid volume that a plurality of reaction cups 3 injected in the short time satisfies preset capacity, in order to guarantee the cleaning performance of a plurality of reaction cups 3.

In this embodiment, the cleaning component 5 may further include at least one pipeline concentrator 56, and the plurality of liquid injection branches 512 may be connected to the pipeline concentrator 56, so that the plurality of liquid injection branches 512 are concentrated together and restrained, and the liquid injection branches 512 are prevented from shaking during liquid injection. This pipeline is concentrated 56 can have a plurality of inlets and respectively with a plurality of liquid outlets of a plurality of inlets intercommunication, a inlet only communicates with a liquid outlet promptly, then one annotates partly connection inlet of liquid branch 512, another partly connection liquid outlet.

In some embodiments, the cleaning component 5 further includes a liquid injection needle 7 connected to the liquid outlet end of the liquid injection pipeline 51, and a liquid suction needle 8 connected to the liquid injection needle 7, wherein the liquid injection needle 7 is disposed in an inclined manner with the liquid suction needle 8 near the upper end of the liquid injection pipeline 51.

That is, the liquid injection needle 7 may be extended into the reaction cup 3 to facilitate the transfer of the cleaning liquid into the reaction cup 3. The pipette needle 8 may be connected to a pipette member to suck the waste liquid in the cuvette 3. The liquid injection needle 7 is generally close to the lower end of the liquid suction needle 8, that is, the lower end of the liquid injection needle 7 is close to the lower end of the liquid suction needle 8, and the upper end of the liquid injection needle 7 close to the liquid injection pipeline 51 can be obliquely arranged with the liquid suction needle 8, so that the upper end of the liquid injection needle 7 close to the liquid injection pipeline 51 is far away from the liquid suction needle 8, thereby facilitating the connection of the liquid injection branch 512 with the liquid injection needle 7.

In this embodiment, the liquid outlet end of the liquid injection pipeline 51 refers to the liquid outlet end of the liquid injection branch 512, the number of the liquid injection needles 7 may be the same as that of the liquid injection branches 512, and the liquid outlet end of each liquid injection branch 512 is connected to one liquid injection needle 7. The number of the liquid suction needles 8 can be the same as that of the liquid injection needles 7, and each liquid suction needle 8 is connected with one liquid injection needle 7.

In addition, the distance between the lower end surface of the liquid suction needle 8 and the cup bottom of the reaction cup 3 is smaller than the distance between the lower end surface of the liquid injection needle 7 and the cup bottom of the reaction cup 3, so that the liquid suction needle 8 can suck away waste liquid in the reaction cup 3.

In some embodiments, referring to fig. 5, the cleaning component 5 further includes a branch component 55 installed in the liquid injection pipeline 51, and the branch component 55 divides the liquid injection pipeline 51 into a main liquid injection path 511 and at least two branch liquid injection paths 512. The number of the liquid injection switch valves 52 is at least two, the liquid injection switch valves 52 are installed in the at least two liquid injection branches 512, and the liquid injection switch valves 52 installed in the liquid injection branches 512 are used as branch switch valves. The drift diameter of the branch switch valve 531 is smaller than the sum of the drift diameters of all the shunt switch valves, and/or the pipe diameter of the branch pipe 53 is smaller than the sum of the pipe diameters of all the liquid injection shunts 512.

That is, only the filling branch 512 is provided with the filling on-off valve 52, and when the branch on-off valve is opened, the filling branch 512 can deliver the cleaning solution to the reaction cup 3. Through making the latus rectum of branch switch valve 531 be less than the latus rectum sum of whole shunt switch valve, and/or, the pipe diameter of branch pipe 53 is less than the pipe diameter sum of whole notes liquid shunt 512, can open simultaneously at a plurality of shunt switch valves, when making a plurality of notes liquid shunt 512 carry the washing liquid to wash a plurality of reaction cups 3 simultaneously, avoid too much washing liquid to flow from branch pipe 53, in order to practice thrift the washing liquid, can also avoid excessively reducing the flow of the washing liquid in a plurality of notes liquid shunt 512 simultaneously, thereby avoid reducing the velocity of flow of the washing liquid in a plurality of notes liquid shunt 512, guarantee that the washing liquid volume that a plurality of reaction cups 3 injected in the short time satisfies preset capacity, in order to guarantee the cleaning performance of a plurality of reaction cups 3.

In some embodiments, referring to fig. 3 to 5, the cleaning component 5 further includes a liquid storage tank 57 for storing the cleaning liquid, a portion of the liquid injection pipeline 51 connected to the liquid inlet end of the liquid injection switch valve 52 is communicated with the liquid storage tank 57, and a portion of the branch pipeline 53 connected to the liquid outlet end of the branch switch valve 531 is communicated with the liquid storage tank 57. That is to say, the part of the branch pipe 53 connected with the liquid inlet end of the branch switch valve 531 is communicated with the part of the liquid injection pipe 51 connected with the liquid inlet end of the liquid injection switch valve 52, which is equivalent to the part of the branch pipe 53 connected with the liquid inlet end of the branch switch valve 531 is communicated with the liquid storage tank 57, and the part of the branch pipe 53 connected with the liquid outlet end of the branch switch valve 531 is also communicated with the liquid storage tank 57, so that the branch pipe 53 can form a loop with the liquid storage tank 57, and after the branch switch valve 531 is opened, the branch pipe 53 not only can release the fluid pressure in the liquid injection pipe 51, but also can make the cleaning liquid in the branch pipe 53 flow back to the liquid storage tank 57, thereby realizing the recycling of the cleaning liquid and saving the cleaning liquid.

In some embodiments, referring to fig. 3 to 5, the cleaning component 5 further includes a diversion block 58 installed in the liquid injection pipe 51, and the branch pipe 53 is connected to the diversion block 58. That is, the diverting block 58 is installed in the part of the liquid injection pipeline 51 connected to the liquid inlet end of the liquid injection switch valve 52, the diverting block 58 is provided with a plurality of diverting ports, the branch pipeline 53 is connected to one diverting port of the diverting block 58 to realize the communication between the branch pipeline 53 and the part of the liquid injection pipeline 51 connected to the liquid inlet end of the liquid injection switch valve 52, and the branch pipeline 53 is connected to the diverting block 58 so as to facilitate the replacement or maintenance of the branch pipeline 53.

In this embodiment, the cleaning component 5 further comprises a pressure sensor 59, the pressure sensor 59 being connected to the diverter block 58. Because the branch pipe 53 and the injection pipe 51 are communicated through the diversion block 58, the pressure sensor 59 can simultaneously sense the fluid pressure in the branch pipe 53 and the injection pipe 51, and after the branch switch valve 531 and the injection switch valve 52 are opened, whether the cleaning liquid in the branch pipe 53 and the injection pipe 51 normally flows can be monitored through the fluid pressure in the branch pipe 53 and the injection pipe 51, for example, after the cleaning component 5 is used for a long time, microorganism accumulation can occur in the branch pipe 53 and the injection pipe 51, which causes the cleaning liquid in the branch pipe 53 and the injection pipe 51 to flow unsmoothly, the fluid pressure in the branch pipe 53 and the injection pipe 51 can be correspondingly changed, when the fluid pressure in the branch pipe 53 and the injection pipe 51 is not at a normal value, the branch pipe 53 and the injection pipe 51 can be maintained or replaced, thereby ensuring the normal flow of the cleaning liquid in the branch pipe 53 and the injection pipe 51, thereby ensuring the cleaning effect of the reaction cup 3.

In this embodiment, the cleaning component 5 further includes a heater 510, and the heater 510 is installed in the liquid injection pipe 51 and is located between the flow dividing block 58 and the liquid injection switch valve 52. The heater 510 may heat the cleaning fluid to 35 deg. -39 deg. to enhance the cleaning effect of the cleaning fluid. In addition, the heater 510 only heats the cleaning liquid in the injection pipeline 51, but not heats the cleaning liquid in the branch pipeline 53, and the heater 510 can heat the cleaning liquid first when the injection switch valve 52 is closed, and after the injection switch valve 52 is opened, the injection pipeline 51 can deliver the heated cleaning liquid to the reaction cups 3, so as to improve the cleaning efficiency of the reaction cups 3.

In this embodiment, the power pump 54 described above may be mounted between the diverter block 58 and the reservoir 57. The cleaning component 5 further comprises a throttle valve 520 installed in the liquid injection pipeline 51, the throttle valve 520 can be installed between the flow dividing block 58 and the power pump 54, and the flow rate of the cleaning liquid in the liquid injection pipeline 51 can be conveniently adjusted through the throttle valve 520 so as to adapt to the cleaning of different types and/or different sizes of reaction cups 3.

In this embodiment, the diverter block 58, heater 510, throttle valve 520, and power pump 54 may all be installed in the main charge circuit 511.

In the above embodiments, the descriptions of the respective embodiments have respective emphasis, and parts that are not described in detail in a certain embodiment may refer to the above detailed descriptions of other embodiments, and are not described herein again.

In a specific implementation, each component or structure may be implemented as an independent entity, or may be combined arbitrarily and implemented as one or several entities, and the specific implementation of each component or structure may refer to the foregoing embodiments, which are not described herein again.

The sample analyzer provided by the embodiment of the present invention is described in detail above, and the principle and the embodiment of the present invention are explained herein by applying specific examples, and the description of the above embodiments is only used to help understanding the method and the core concept of the present invention; meanwhile, for those skilled in the art, according to the idea of the present invention, there may be variations in the specific embodiments and the application scope, and in summary, the content of the present specification should not be construed as a limitation to the present invention.

Claims

1. A sample analysis apparatus, comprising: a sample part, a reagent part, a reaction cup, a measuring part and a cleaning part;

the sample component is used for dispensing a sample to be tested;

the reagent component is used for dispensing a reagent;

the measuring component is used for carrying out project test on the reaction liquid;

2. The sample analyzer as claimed in claim 1, wherein the cleaning member further comprises a branch switch valve installed in the branch conduit, and a portion of the liquid injection conduit connected to a liquid inlet end of the liquid injection switch valve communicates with a portion of the branch conduit connected to a liquid inlet end of the branch switch valve.

3. The sample analysis device of claim 2, further comprising a control unit connected to the priming on-off valve and the branch on-off valve;

4. The sample analysis device of claim 2, wherein the cleaning component further comprises a flow splitting component mounted in the liquid injection conduit, the flow splitting component dividing the liquid injection conduit into a main liquid injection path and at least two liquid injection paths;

5. The sample analyzer as claimed in claim 4, wherein the ratio of the passage of the branch switching valve to the passage of the main passage switching valve is 0.9 to 1.3, and/or the ratio of the pipe diameter of the branch pipe to the pipe diameter of the main liquid-filled passage is 0.9 to 1.3.

6. The sample analyzer as claimed in claim 4, wherein the number of the liquid injection switching valves is at least two, the liquid injection switching valves are installed in at least two of the liquid injection branches, and the liquid injection switching valves installed in the liquid injection branches are used as branch switching valves;

7. The sample analysis device of claim 2, wherein the cleaning component further comprises a flow splitting component mounted in the liquid injection conduit, the flow splitting component dividing the liquid injection conduit into a main liquid injection path and at least two liquid injection branches;

8. The sample analyzing apparatus according to claim 6 or 7, wherein a ratio of a path of the branch switching valve to a sum of paths of all the shunt switching valves is 3: 16 to 3: 8, and/or the ratio of the pipe diameter of the branch pipeline to the sum of all the pipe diameters of the liquid injection branches is 3: 16 to 3: 8.

9. the sample analyzer as claimed in claim 6 or 7, wherein the ratio of the bypass opening/closing valve diameter to the sum of all the bypass opening/closing valve diameters is 7: 32 to 9: 32 and/or the ratio of the pipe diameter of the branch pipeline to the sum of the pipe diameters of all the liquid injection branches is 7: 32 to 9: 32.

10. the sample analysis device according to any one of claims 2 to 7, wherein the cleaning component further comprises a liquid storage tank for storing a cleaning liquid, a part of the liquid injection pipeline connected with the liquid inlet end of the liquid injection switch valve is communicated with the liquid storage tank, and a part of the branch pipeline connected with the liquid outlet end of the branch switch valve is communicated with the liquid storage tank.

11. The sample analysis device of any one of claims 1 to 7, wherein the cleaning component further comprises a diverter block mounted in the priming conduit, the branch conduit connecting the diverter block.

12. The sample analysis device of claim 11, wherein the cleaning component further comprises a pressure sensor coupled to the diverter block.

13. The sample analysis device of claim 11, wherein the cleaning component further comprises a heater mounted in the priming conduit and positioned between the diverter block and the priming switch valve.

14. The sample analysis device of any of claims 1-7, wherein the wash solution is deionized water.

15. The sample analysis device according to any one of claims 1 to 7, wherein the cleaning member further comprises a liquid injection needle connected to the liquid outlet end of the liquid injection pipe, and a liquid suction needle connected to the liquid injection needle;