CN216602930U

CN216602930U - Herpes virus infection diagnosis stick for oral mucosa exudate

Info

Publication number: CN216602930U
Application number: CN202123125384.4U
Authority: CN
Inventors: 阎岩
Original assignee: Wuxi Fifth Peoples Hospital
Current assignee: Wuxi Fifth Peoples Hospital
Priority date: 2021-12-13
Filing date: 2021-12-13
Publication date: 2022-05-27
Anticipated expiration: 2031-12-13

Abstract

The utility model discloses an oral mucosa exudate herpesvirus infection diagnosis rod which comprises an outer sleeve, wherein the top of the outer sleeve is provided with a cylindrical groove, the bottom of the cylindrical groove is provided with a through hole, a core rod penetrates through the through hole, the core rod is in sliding fit with the through hole, the side wall of the top of the core rod is fixedly sleeved with a sealing ring, the sealing ring is in sliding contact with the cylindrical groove, the top end of the core rod is fixedly provided with a sampling head, the outside of the sampling head is coated with a cotton sleeve, the bottom end of the core rod is fixedly provided with a button, a spring is arranged between the button and the outer sleeve, the spring is sleeved on the outer side of the core rod, the side wall of the core rod is embedded with a chromatography detection assembly, and the chromatography detection assembly is communicated with the cotton sleeve. The device has the advantages of simple structure, convenient operation, no need of blood collection, no need of collection of oral mucosa exudate for detection, no damage to human body, reduced discomfort to human body, and great convenience for herpes virus infection detection.

Description

Oral mucosa exudate herpes virus infection diagnosis stick

Technical Field

The utility model relates to the technical field of biological diagnosis, in particular to an oral mucosa exudate herpes virus infection diagnosis stick.

Background

The oral herpes includes oral herpes simplex, oral herpes zoster, and hand-foot-and-mouth disease. Oral herpes simplex is caused by herpes simplex virus, and has many infections on human body, and oral cavity, skin, eyes, perineum, nervous system and the like are parts which are easy to be invaded. Humans are their natural hosts. The oral cavity is divided into primary herpetic stomatitis and recurrent herpetic stomatitis, wherein the primary herpetic stomatitis is often seen in children, and the recurrent herpetic stomatitis is often seen in adults and mainly expressed as herpes labialis. Oral herpes zoster is an acute infectious disease caused by varicella zoster virus.

Currently, the most common method for detecting the above infectious diseases is immunoassay, which includes two methods, namely traditional enzyme-linked immunosorbent assay and colloidal gold method. The colloidal gold method is divided into two modes of immunochromatography and immunofiltration, wherein the immunochromatography is most convenient and rapid and is widely applied, but most of the existing immunochromatography uses blood as a sample, blood components are complex, the blood components need to be processed before detection, the procedure is complex, and some patients can have uncomfortable emotions such as fear in blood collection.

SUMMERY OF THE UTILITY MODEL

The utility model aims to provide a diagnosis bar for herpes virus infection of oral mucosa exudate, which aims to solve the problems in the prior art.

In order to achieve the purpose, the utility model provides the following scheme: the utility model provides an oral mucosa exudate herpesvirus infection diagnosis rod which comprises an outer sleeve, wherein the top of the outer sleeve is provided with a cylindrical groove, the bottom of the cylindrical groove is provided with a through hole, a core rod penetrates through the through hole and is in sliding fit with the through hole, the side wall of the top of the core rod is fixedly sleeved with a sealing ring, the sealing ring is in sliding connection with the cylindrical groove, the top end of the core rod is fixedly provided with a sampling head, the outside of the sampling head is coated with a cotton sleeve, the bottom end of the core rod is fixedly provided with a button, a spring is arranged between the button and the outer sleeve, the spring is sleeved on the outer side of the core rod, the side wall of the core rod is embedded with a chromatography detection assembly, and the chromatography detection assembly is communicated with the cotton sleeve.

Preferably, the chromatography determine module includes the mounting groove, the mounting groove is seted up in the plug lateral wall, mounting groove bottom fixed mounting has the NC membrane, NC membrane top overlap joint has the colloidal gold pad, the colloidal gold pad top overlap joint has the sample pad, NC membrane bottom overlap joint has absorbent filter paper, colloidal gold pad, sample pad and absorbent filter paper all with mounting groove bottom fixed connection, it is equipped with detection line and quality control line to inlay on the NC membrane.

Preferably, an observation port communicated with the through hole is formed in the side face of the outer sleeve, an observation window is fixedly installed on the observation port, and the position of the observation window corresponds to the position of the NC membrane.

Preferably, a plurality of holes communicated with the mounting groove are formed in the sampling head, a lead is arranged in each hole in a penetrating mode, one end of the lead is fixedly connected with the cotton sleeve, and the other end of the lead is fixedly connected with the sample pad.

Preferably, the diameter of the sealing ring is larger than that of the through hole and smaller than that of the cylindrical groove.

Preferably, the bottom end of the sealing ring is a conical surface.

Preferably, a holding handle is fixedly mounted at the bottom of the outer sleeve.

Preferably, the top end of the cylindrical groove is in threaded connection with a sealing cover.

The utility model discloses the following technical effects: when the mouth-washing device is used, a patient rinses mouth with clear water, then opens the mouth, medical staff holds the outer sleeve, a button is pressed by a thumb, the button pushes the core rod to slide upwards, the cotton sleeve extends out of the cylindrical groove, the head end of the device extends into the oral cavity of the patient, the cotton sleeve is in contact with the oral wall of the patient, the cotton sleeve is scraped for more than 20 times up and down, the force is based on the cheek part micro-protrusion, then the device is taken out from the oral cavity of the patient, the button is released, the button is pushed downwards by the spring, the core rod is enabled to slide downwards, the cotton sleeve enters the cylindrical groove, the sealing ring is in abutting connection with the top end of the through hole, the sealing ring and the top end of the through hole form a closed space, a dropper is used for injecting a phosphoric acid buffer solution into the cylindrical groove to enable the phosphoric acid buffer solution to submerge the top of the cotton sleeve, the oral mucosa exudate is diluted, the oral mucosa exudate enters the chromatography detection component from the cotton sleeve, the oral mucosa detection component carries out chromatography detection, to see if the patient is infected with herpes virus.

The device has the advantages of simple structure, convenient operation, no need of blood collection, no need of collection of oral mucosa exudate for detection, no damage to human body, reduced discomfort to human body, and great convenience for herpes virus infection detection.

Drawings

In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings needed to be used in the embodiments will be briefly described below, and it is obvious that the drawings in the following description are only some embodiments of the present invention, and it is obvious for those skilled in the art to obtain other drawings without inventive exercise.

FIG. 1 is an external structural view of a diagnosis stick for herpes virus infection of oral mucosa exudate;

FIG. 2 is an internal structure view of a diagnosis stick for herpes virus infection of oral mucosa exudate;

FIG. 3 is a schematic structural diagram of a chromatographic detection assembly and a sampling head;

FIG. 4 is a left side view of the chromatographic detection assembly;

FIG. 5 is a schematic structural view of a seal ring;

in the figure: 1. an outer sleeve; 2. a cylindrical groove; 3. a through hole; 4. a core rod; 5. a seal ring; 6. a sampling head; 7. cotton sleeves; 8. a button; 9. a spring; 10. mounting grooves; 11. NC film; 12. a colloidal gold pad; 13. a sample pad; 14. water-absorbing filter paper; 15. detecting lines; 16. a quality control line; 17. a lead wire; 18. a sealing cover; 19. a holding handle; 20. and (4) an observation window.

Detailed Description

The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.

In order to make the aforementioned objects, features and advantages of the present invention comprehensible, embodiments accompanied with figures are described in further detail below.

The utility model provides an oral mucosa exudate herpesvirus infection diagnosis rod which comprises an outer sleeve 1, wherein the top of the outer sleeve 1 is provided with a cylindrical groove 2, the bottom of the cylindrical groove 2 is provided with a through hole 3, a core rod 4 penetrates through the through hole 3, the core rod 4 is in sliding fit with the through hole 3, the side wall of the top of the core rod 4 is fixedly sleeved with a sealing ring 5, the sealing ring 5 is in sliding contact with the cylindrical groove 2, the top end of the core rod 4 is fixedly provided with a sampling head 6, the outer part of the sampling head 6 is wrapped with a cotton sleeve 7, the bottom end of the core rod 4 is fixedly provided with a button 8, a spring 9 is arranged between the button 8 and the outer sleeve 1, the spring 9 is sleeved on the outer side of the core rod 4, the side wall of the core rod 4 is embedded with a chromatography detection assembly, and the chromatography detection assembly is communicated with the cotton sleeve 7.

When the device is used, a patient rinses mouth with clear water, then the mouth is opened, a medical worker holds the outer sleeve 1, the thumb presses the button 8, the button 8 pushes the core rod 4 to slide upwards, the cotton sleeve 7 extends out of the cylindrical groove 2, the head end of the device extends into the oral cavity of the patient, the cotton sleeve 7 is in contact with the inner wall of the oral cavity of the patient, the cotton sleeve 7 is scraped for more than 20 times up and down, the force is based on the micro-convex of the cheek part, then the device is taken out from the oral cavity of the patient, the button 8 is loosened, the button 8 is pushed downwards by the spring 9, the core rod 4 is driven to slide downwards, the cotton sleeve 7 enters the cylindrical groove 2, the sealing ring 5 is in contact connection with the top end of the through hole 3, the sealing ring 5 and the top end of the through hole 3 form a closed space, a dropper is used for injecting phosphoric acid buffer solution into the cylindrical groove 2, so that the phosphoric acid buffer solution does not pass through the top of the cotton sleeve 7, the oral mucosa exudate after dilution is diluted, the oral mucosa exudate enters the chromatography detection assembly from the cotton sleeve 7, and carrying out chromatographic detection on the oral mucosa exudate of the chromatographic detection component to check whether the patient is infected with the herpes virus.

Further optimize the scheme, chromatography determine module includes mounting groove 10, mounting groove 10 is seted up in 4 lateral walls of plug, mounting groove 10 bottom fixed mounting has

NC membrane

11, 11 top overlap joints of NC membrane have

colloidal gold pad

12, 12 top overlap joints of colloidal gold pad have sample pad 13, 11 bottom overlap joints of NC membrane have water-absorbing filter paper 14, colloidal gold pad 12, sample pad 13 and water-absorbing filter paper 14 all with mounting groove 10 bottom fixed connection, it is equipped with detection line 15 and quality control line 16 to inlay on the NC membrane 11. The detection line 15 is positioned at one side close to the colloidal gold pad 12, the quality control line 16 is positioned at one side close to the absorbent filter paper 14, the diluted oral mucosa exudate enters the colloidal gold pad 12 through the sample pad 13, is labeled with antigen or antibody by the colloidal gold pad 12, then enters the NC membrane 11, and judges the detection result according to the color development states of the detection line 15 and the quality control line 16, if the detection line 15 and the quality control line 16 both develop color, the sample is judged to be positive; if the detection line 15 appears and the quality control line 16 does not appear, the sample is judged to be negative; the detection line 15 and the quality control line 16 do not appear, or the detection line 15 does not appear the quality control line 16, and the detection is judged to be invalid, and the immunochromatography colloidal gold technology is a novel diagnosis technology, is widely applied and is not described herein any more.

According to a further optimized scheme, an observation port communicated with the through hole 3 is formed in the side face of the outer sleeve 1, an observation window 20 is fixedly mounted on the observation port, the position of the observation window 20 corresponds to the position of the NC film 11, the color development states of the detection line 15 and the quality control line 16 can be observed through the observation window 20, and a detection result is judged.

Further optimize the scheme, set up a plurality of holes that communicate with mounting groove 10 in the sampling head 6, wear to be equipped with lead wire 17 in the hole, lead wire 17 is the material that absorbs water, lead wire 17 one end and cotton-padded sleeve 7 fixed connection, lead wire 17 other end and sample pad 13 fixed connection, can inhale from cotton-padded sleeve 7 with the oral mucosa exudate after diluting, transport sample pad 13 through lead wire 17, carry out follow-up detection, use lead wire 17 to transport and can avoid the oral mucosa after diluting to ooze a large amount of inflow sample pad 13.

Further optimize scheme, the diameter of sealing ring 5 is greater than the diameter of through-hole 3, makes things convenient for sealing ring 5 to cover through-hole 3 completely, reaches sealed effect, and is less than the diameter of cylinder groove 2, makes things convenient for sealing ring 5 to slide from top to bottom in cylinder groove 2.

Further optimization scheme, 5 bottom ends of sealing ring are the toper face, make 5 bottom ends of sealing ring partly be located through-hole 3 inside, fully with 3 edge contact of through-hole, reach good sealed effects.

Further optimizing the scheme, outer sleeve 1 bottom fixed mounting has holding handle 19, when pressing button 8, forefinger and middle finger can catch on holding handle 19, and convenient application of force avoids hand skidding when gathering oral mucosa exudate, influences the collection effect.

Further optimize the scheme, 2 top threaded connection in cylinder groove have sealed lid 18, inject phosphoric acid buffer solution in cylinder groove 2 after, can install sealed lid 18, rock this device, make phosphoric acid buffer solution and oral cavity mucous membrane exudate intensive mixing, reach good dilution effect.

In the description of the present invention, it is to be understood that the terms "longitudinal", "lateral", "upper", "lower", "front", "rear", "left", "right", "vertical", "horizontal", "top", "bottom", "inner", "outer", and the like, indicate orientations or positional relationships based on those shown in the drawings, are merely for convenience of description of the present invention, and do not indicate or imply that the referenced devices or elements must have a particular orientation, be constructed and operated in a particular orientation, and thus, are not to be construed as limiting the present invention.

The above-described embodiments are only intended to illustrate the preferred embodiments of the present invention, and not to limit the scope of the present invention, and various modifications and improvements made to the technical solution of the present invention by those skilled in the art without departing from the spirit of the present invention should fall within the protection scope defined by the claims of the present invention.

Claims

1. A diagnosis stick for herpes virus infection of oral mucosa exudate is characterized in that: comprises an outer sleeve (1), a cylindrical groove (2) is arranged at the top of the outer sleeve (1), a through hole (3) is arranged at the bottom of the cylindrical groove (2), a core rod (4) is arranged in the through hole (3) in a penetrating way, the core rod (4) is in sliding fit with the through hole (3), a sealing ring (5) is fixedly sleeved on the side wall of the top of the core rod (4), the sealing ring (5) is in sliding contact with the cylindrical groove (2), the top end of the core rod (4) is fixedly provided with a sampling head (6), the sampling head (6) is externally coated with a cotton sleeve (7), the bottom end of the core rod (4) is fixedly provided with a button (8), a spring (9) is arranged between the button (8) and the outer sleeve (1), spring (9) cover is located the plug (4) outside, inlay on plug (4) lateral wall and be equipped with the chromatography detection subassembly, the chromatography detection subassembly with cotton cover (7) intercommunication.

2. The oral mucosa exudate herpesvirus infection diagnostic stick as claimed in claim 1, characterized in that: the chromatography detection subassembly includes mounting groove (10), mounting groove (10) are seted up in plug (4) lateral wall, mounting groove (10) bottom fixed mounting has NC membrane (11), NC membrane (11) top overlap joint has colloidal gold pad (12), colloidal gold pad (12) top overlap joint has sample pad (13), NC membrane (11) bottom overlap joint has absorbent filter paper (14), colloidal gold pad (12), sample pad (13) and absorbent filter paper (14) all with mounting groove (10) bottom fixed connection, it is equipped with detection line (15) and matter accuse line (16) to inlay on NC membrane (11).

3. The oral mucosa exudate herpesvirus infection diagnostic stick as claimed in claim 2, characterized in that: an observation port communicated with the through hole (3) is formed in the side face of the outer sleeve (1), an observation window (20) is fixedly mounted on the observation port, and the position of the observation window (20) corresponds to the position of the NC film (11).

4. The oral mucosa exudate herpesvirus infection diagnostic stick as claimed in claim 2, characterized in that: set up in sampling head (6) a plurality of with the hole of mounting groove (10) intercommunication, wear to be equipped with lead wire (17) in the hole, lead wire (17) one end with cotton cover (7) fixed connection, lead wire (17) the other end with sample pad (13) fixed connection.

5. The oral mucosa exudate herpesvirus infection diagnostic stick as claimed in claim 1, characterized in that: the diameter of the sealing ring (5) is larger than that of the through hole (3) and smaller than that of the cylindrical groove (2).

6. The oral mucosa exudate herpesvirus infection diagnostic stick as claimed in claim 1, characterized in that: the bottom end of the sealing ring (5) is a conical surface.

7. The oral mucosa exudate herpesvirus infection diagnostic stick as claimed in claim 1, characterized in that: a holding handle (19) is fixedly arranged at the bottom of the outer sleeve (1).

8. The oral mucosa exudate herpesvirus infection diagnostic stick as claimed in claim 1, characterized in that: the top end of the cylindrical groove (2) is in threaded connection with a sealing cover (18).