CN205785930U - A kind of tear harvester - Google Patents

A kind of tear harvester Download PDF

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Publication number
CN205785930U
CN205785930U CN201620312852.9U CN201620312852U CN205785930U CN 205785930 U CN205785930 U CN 205785930U CN 201620312852 U CN201620312852 U CN 201620312852U CN 205785930 U CN205785930 U CN 205785930U
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China
Prior art keywords
harvester
tear
utility
model
buffer unit
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CN201620312852.9U
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Chinese (zh)
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黄静峰
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Guangdong Shengze Kanghua Biological Pharmaceutical Co Ltd
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Guangdong Shengze Kanghua Biological Pharmaceutical Co Ltd
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Abstract

This utility model belongs to in-vitro diagnosis field, particularly relates to a kind of tear harvester.This utility model provides a kind of tear harvester, and described tear harvester includes: harvester, buffer unit and pressurizing unit;The rear end of described harvester is connected with the front end of described buffer unit, and the front end of described pressurizing unit is connected with the rear end of described buffer unit.Compared with glass capillary pipette, the tear harvester that this utility model provides more preferably grips after being easy to testing staff's sampling and gathering and extrudes sample, simultaneously, it is possible to alleviate the fear of patient.Compared with water absorbing material, the tear harvester that this utility model provides is easier to sample is carried out accurate quantitative analysis.Solving in prior art, tear harvester is primarily present the technological deficiency can not simultaneously taken into account between convenience and quantitative sampling of sampling.

Description

A kind of tear harvester
Technical field
This utility model belongs to in-vitro diagnosis field, particularly relates to a kind of tear harvester.
Background technology
Containing a large amount of factors and albumen in ocular tear, generation development and molecular mechanism with disease are in close relations, pass through Obtain tear and carry out the detection of disease biomarker, to the diagnosis of ophthalmic diseases, especially eye surface diseases, Differential Diagnosis, Follow up a case by regular visits to, Outcome measure and prognosis prediction significant.
At present, the tear acquisition method operation used during domestic and international clinical research is complicated, and patient often feels nervous, nothing Method loosens cooperation medical personnel, causes gathering tear or collection effect is undesirable.The tear harvester being currently mainly used Specifically include that glass capillary pipette and two kinds of tear harvesters of water absorbing material.Due to the shape of glass capillary pipette, material and Design, has the disadvantage that glass capillary pipette external diameter is many within 1mm, elongated, glass material to the sharp sensation of people, when During direct-view capillary glass tube, patient is easily generated fear or is nervous, it is impossible to preferably coordinate the operation of examiner;Meanwhile, Glass capillary pipette is too thin, and examiner is difficult to hand-held and operation;3rd, the pointed edge of glass capillary pipette, without special place Reason, and be glass material, the sharpest, easily cause epithelial damage;4th, after drawing tear, in order to intraluminal liquid Blowout, carries out next step inspection, generally also needs to assemble extra device (such as: rubber ear washing bulb) temporarily, increase operator's Operating procedure, operates more complicated.Water absorbing material as the operation principle of tear harvester is: the absorbent materials such as Pilus Caprae seu Ovis terylene Inside contact lower eyelid (palpebral conjunctiva), utilize the water absorbing properties of material to draw tear, subsequently absorbent material is placed in buffer, shape Become containing tear active factors and the solution of albumen, then carry out corresponding analysis.The tear harvester master of this type of water absorbing material Shortcoming to be existed is: first, it is impossible to quantitatively: using absorbent material contact palpebral conjunctiva, absorbent material is by tear moistening thus enters Row gathers, but cannot accurately measure the Tear volume drawn, and therefore cannot be carried out detection by quantitative or experiment, and certain journey The result of qualitative test is affected on degree;Second, repetitious stimulation: in order to make absorbent material can draw tear, need to be anti-by absorbent material Conjunctiva is touched in multiple connection, may cause a large amount of secretion of tear, makes ocular tear film composition change;3rd, patient is uncomfortable: eye Table is distributed a large amount of teleneurons, and absorbent material contacts conjunctiva repeatedly, and patient can be caused uncomfortable;4th, the sample of collection is diluted: Tear is adsorbed in absorbent material, therefore needs to be placed in buffer absorbent material, treats that tear protein and active factors are dissolved in buffering After liquid, can be analyzed.The tear that this process can cause sample size own minimum is diluted so that original concentration is the lowest Target analyte be more difficult to be detected, thus limit its clinical practice.Therefore, tear harvester of the prior art, It is primarily present the technological deficiency can not simultaneously taken into account between convenience and quantitative sampling of sampling.
Therefore, develop a kind of tear harvester, be used for solving tear harvester of the prior art, be primarily present and adopt The technological deficiency can not simultaneously taken into account between sample convenience and quantitative sampling, becomes urgently to be resolved hurrily the asking of those skilled in the art Topic.
Utility model content
In view of this, this utility model provides a kind of tear harvester, is used for solving in prior art, tear harvester It is primarily present the technological deficiency can not simultaneously taken into account between convenience and quantitative sampling of sampling.
This utility model provides a kind of tear harvester, and described tear harvester includes: harvester, buffer unit and Pressurizing unit;The rear end of described harvester is connected with the front end of described buffer unit, and the front end of described pressurizing unit is with described The rear end of buffer unit connects.
Preferably, described tear harvester also includes: sealing device;Described sealing device is enclosed within described harvester and institute State the outside of buffer unit.
Preferably, rear end or the upper end of described pressurizing unit is provided with cavernous structure.
Preferably, described harvester is capillary pipette.
Preferably, described buffer unit be shaped as beloid pyramidal structure.
Preferably, described pressurizing unit is elastic squeezing unit.
Preferably, described harvester is transparent harvester.
Preferably, described buffer unit is transparent caching device.
In sum, this utility model provides a kind of tear harvester, and described tear harvester includes: harvester, Buffer unit and pressurizing unit;The rear end of described harvester is connected with the front end of described buffer unit, described pressurizing unit Front end is connected with the rear end of described buffer unit.A kind of tear harvester that this utility model provides, utilizes harvester collection To tear, when tear arrives the junction of harvester and buffer unit, sample complete, when tear is detected by needs Time, can be by extruding pressurizing unit so that tear discharges tear harvester.Compared with glass capillary pipette, this utility model carries The tear harvester of confession more preferably grips is easy to testing staff's sampling, simultaneously, it is possible to alleviate the fear of patient.With water absorbing material Comparing, the tear harvester that this utility model provides is easier to sample is carried out accurate quantitative analysis.Solve in prior art, tear Liquid harvester is primarily present the technological deficiency can not simultaneously taken into account between convenience and quantitative sampling of sampling.
Accompanying drawing explanation
In order to be illustrated more clearly that this utility model embodiment or technical scheme of the prior art, below will be to embodiment Or the required accompanying drawing used is briefly described in description of the prior art, it should be apparent that, the accompanying drawing in describing below is only It is embodiment of the present utility model, for those of ordinary skill in the art, on the premise of not paying creative work, also Other accompanying drawing can be obtained according to the accompanying drawing provided.
One of them structural representation of a kind of tear harvester that Fig. 1 provides for this utility model;
Another structural representation of a kind of tear harvester that Fig. 2 provides for this utility model;
Wherein, harvester 1, buffer unit 2, pressurizing unit 3, sealing device 4 and cavernous structure 31.
Detailed description of the invention
This utility model provides a kind of tear harvester, is used for solving tear harvester of the prior art, mainly deposits In the technological deficiency can not taken into account between sampling convenience and quantitative sampling simultaneously.
Technical scheme in this utility model embodiment will be clearly and completely described below, it is clear that described Embodiment is only a part of embodiment of this utility model rather than whole embodiments.Based on the enforcement in this utility model Example, the every other embodiment that those of ordinary skill in the art are obtained under not making creative work premise, broadly fall into The scope of this utility model protection.
In order to this utility model is described in more detail, a kind of tear collection this utility model provided below in conjunction with embodiment Device, is specifically described.
Referring to Fig. 1 and Fig. 2, this utility model provides a kind of tear harvester, including: harvester 1, buffer unit 2 and pressurizing unit 3;The rear end of harvester 1 is connected with 2 front ends of buffer unit, the front end of pressurizing unit 3 and buffer unit 2 Rear end connect.A kind of tear harvester that this utility model provides, utilizes harvester 1 to collect tear, when tear arrives During the junction of harvester 1 and buffer unit 2, sample complete, after utilizing harvester 1 to collect tear, when needs are right When tear detects, squeezable pressurizing unit 3 so that tear discharges tear harvester.Compared with glass capillary pipette, this reality More preferably grip with the tear harvester of novel offer and be easy to testing staff's sampling, simultaneously, it is possible to alleviate the fear of patient.With suction Water-based material is compared, and the tear harvester that this utility model provides is easier to sample is carried out accurate quantitative analysis.Solve existing skill In art, tear harvester is primarily present the technological deficiency can not simultaneously taken into account between convenience and quantitative sampling of sampling.
In order to ensure that harvester is aseptic and prevent the ocular fluid samples collected to be contaminated, the one that this utility model provides Tear harvester also includes: sealing device 4;Sealing device 4 is enclosed within harvester 1 and the outside of buffer unit 2.Meanwhile, at tear Before liquid harvester does not also use, sealing device 4 is not so that the tip of harvester 1 is contaminated and collides the damage brought Bad.
In order to the sample of determined volume can quickly be drawn by tear harvester by siphon capillarity, this utility model carries The rear end of the pressurizing unit 3 of a kind of tear harvester of confession is provided with cavernous structure 31.After tear harvester is collected tear, Discharge for the ease of tear, in order to carry out next step detection, the extruding dress of a kind of tear harvester that this utility model provides Put 3 there is elasticity can be extruded.After sample collecting, first sample is mixed with buffer if needed, harvester 1 can be inserted In buffer pipe, block cavernous structure 31 with finger, extrude pressurizing unit 3, sample is blown in buffer pipe, then by release Pressure is drawn buffer and is entered in harvester 1, the most again blocks cavernous structure 31 with finger, and extrudes pressurizing unit simultaneously 3, liquid is blown out.After sample collecting, it is also possible to by blocking cavernous structure 31 with finger, extrude pressurizing unit 3, directly by sample Product are blown into the well in detection device.
For ease of sampling, in this utility model embodiment, harvester 1 is capillary pipette.Utilize capillarity (that is: liquid The surface captivation to the surface of solids) draw liquid.In capillary pipette inserts immersion liquid, intraluminal fluid face rises, and is higher than Outside pipe.Liquid level can be examined by collection head transparent tube standing motionless as if facing a wall, sample when capillary pipette is hydraulically full complete.
For realize accurate quantitative analysis sampling, in this utility model embodiment, harvester 1 be shaped as front end capillary pipette after The front fine and rear thick funnel structure that portion's caliber strengthens rapidly, the rear end of pressurizing unit 3 is provided with cavernous structure 31 simultaneously.Capillary is inhaled The internal diameter of pipe and length determine the liquid volume drawn, i.e. collection capacity.Inhale when ocular fluid samples is full of harvester 1, i.e. capillary Pipe, siphon capillarity i.e. stops.
On the basis of short and small convenient gripping tried one's best by tear harvester, meet multi-level use demand, it is achieved accurate fixed The collection capacity of volume tear of amount, in this utility model embodiment, buffer unit 2 be shaped as beloid pyramidal structure. The design of pyramidal structure, not only convenient gripping, and volume is little and mellow and full, can alleviate the fear of patient while convenient use Sense.
Discharge after gathering for the ease of tear, in this utility model embodiment, pressurizing unit 3 is elastic squeezing unit. Use the least power just can realize the discharge of tear, simple operation.
For ease of observing the collection situation of tear, in this utility model embodiment, harvester 1 is transparent harvester, Buffer unit 2 is transparent caching device.
From above technical scheme it should be apparent that above-mentioned provide only gather tear embodiment, art technology Personnel can clearly draw, on the premise of not paying creative work, and a kind of tear harvester that this utility model provides Can be used for the collecting work of the various body fluid such as saliva, urine, blood.
In brief, a kind of tear harvester that this utility model provides, have the following advantages.First, safety: this reality Structure with a kind of tear harvester of novel offer is more mellow and fuller, makes the roundest and the most smooth finishing with the position of patient contact, normally The lower noinvasive of operation is painless, also eyeball ocular will not be produced infringement.Second, ease for operation: a kind of tear that this utility model provides Liquid harvester designs according to principle of human engineering, makes the length of harvester, diameter be suitable for hand-held and do accurate operation in ocular. 3rd, to sample rapid and simple, a kind of tear harvester design that this utility model provides applies capillary siphoning action principle, Harvester is that the rear end of capillary tube that the smooth rounding of surfaces externally and internally, internal diameter are tiny and pressurizing unit has cavernous structure, tear Harvester can be quickly entered.4th, quantitative sampling: utilize the internal diameter of harvester and length accurately to control to suck the body of liquid Long-pending, establish good basis for the concentration of biomarker in quantitative analysis tear.5th, sampling sample presentation integration: tear collection After device gathers liquid, generally need to be transported on suitable verifying attachment test (such as colloidal gold card etc.) or in instrument and equipment, this The tear harvester of utility model design itself carries the resilient squeezable rear pipe of tool, can be by harvester and apparatus for temporary storage Tear blowout, it is achieved sampling sample presentation integration.6th, improve those who are investigated's experience: mellow and full full in harvester industrial design, To patient with the security;Utilize fine mould, make the collection head similar with glass capillary straw diameter most advanced and sophisticated, not in contact with (or inconspicuous stimulation) ocular tissue, it is achieved noinvasive is painless.
By above description it should be apparent that a kind of tear harvester of this utility model offer, solve existing In technology, tear harvester is primarily present the technological deficiency can not simultaneously taken into account between convenience and quantitative sampling of sampling.With Time, in clinical practice and industry application aspect, all it is significant.In terms of clinical value, as the unique nothing of ophthalmology Create desirable body fluid class biological sample, containing a large amount of factors and albumen in ocular tear, the generation development with disease and molecule machine Make in close relations, but be because on market or the most convenient, safe and effective tear harvester or method, tear The collection of liquid sample and analysis are only limitted to minority professional scientific researcher and scientific research character, and this is to lack to detect the external of tear always One of key reason of diagnostic reagent, various biochemistrys, protein analysis detection technique or immunologic detection method all fail should Diagnosis for ophthalmic diseases.A kind of tear harvester that this utility model provides, has convenience, safe and effective advantage. Meanwhile, the presence or absence of various active factorses, protein factor and biomarker in tear or its concentration, react ocular Health and pathological state.Gather specified disease patient tear after, to its composition, certain biomarker factor or albumen because of Son measures analysis, is conducive to studying the Molecular Pathogcnesis of this disease.Detect, to ophthalmology disease by obtaining tear The diagnosis of disease, especially eye surface diseases, Differential Diagnosis, follow up a case by regular visits to, Outcome measure and prognosis prediction significant.Should in industry Using value aspect, compared with prior art, i.e. glass capillary pipette is compared with water absorbing material, and this utility model provides A kind of tear harvester is can quantitatively, in terms of precision, accuracy, ease for operation, convenience and user experience, have significantly Lifting, probability and practicality will be provided for clinical tear collection, promote development and the ophthalmology of tear correlation detection technology External diagnosis reagent product development and application, strengthen ophthalmic diseases and precisely diagnose and treat.
In sum, this utility model provides a kind of tear harvester, including: harvester 1, buffer unit 2 and squeeze Pressure device 3;The rear end of harvester 1 is connected with 2 front ends of buffer unit, the front end of buffer unit 3 and the rear end of apparatus for temporary storage 1 Connect..A kind of tear harvester that this utility model provides, utilizes harvester 1 to collect tear, gathers dress when tear arrives Put 1 with the junction of buffer unit 2 time, sample complete, after utilizing harvester 1 to collect tear, when tear is entered by needs During row detection, squeezable pressurizing unit 3 so that tear discharges tear harvester.Compared with glass capillary pipette, this utility model The tear harvester provided more preferably grips is easy to testing staff's sampling, simultaneously, it is possible to alleviate the fear of patient.With water absorption material Material is compared, and the tear harvester that this utility model provides is easier to sample is carried out accurate quantitative analysis.Solve in prior art, tear Liquid harvester is primarily present the technological deficiency can not simultaneously taken into account between convenience and quantitative sampling of sampling.
The above is only preferred implementation of the present utility model, it is noted that for the common skill of the art For art personnel, on the premise of without departing from this utility model principle, it is also possible to make some improvements and modifications, these improve and Retouching also should be regarded as protection domain of the present utility model.

Claims (7)

1. a tear harvester, it is characterised in that described tear harvester includes: harvester, buffer unit and extruding dress Put;
The rear end of described harvester is connected with the front end of described buffer unit, the front end of described pressurizing unit and described buffering dress The rear end put connects;Rear end or the upper end of described pressurizing unit are provided with cavernous structure.
Tear harvester the most according to claim 1, it is characterised in that described tear harvester also includes: sealing device;
Described sealing device is enclosed within described harvester and the outside of described buffer unit.
Tear harvester the most according to claim 1, it is characterised in that described harvester is capillary pipette.
Tear harvester the most according to claim 1, it is characterised in that being shaped as of described buffer unit is beloid Pyramidal structure.
Tear harvester the most according to claim 1, it is characterised in that described pressurizing unit is elastic squeezing unit.
Tear harvester the most according to claim 1, it is characterised in that described harvester is transparent harvester.
Tear harvester the most according to claim 1, it is characterised in that described buffer unit is transparent caching device.
CN201620312852.9U 2016-04-13 2016-04-13 A kind of tear harvester Active CN205785930U (en)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105675352A (en) * 2016-04-13 2016-06-15 广东盛泽康华生物医药有限公司 Tear fluid collector

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105675352A (en) * 2016-04-13 2016-06-15 广东盛泽康华生物医药有限公司 Tear fluid collector
WO2017177886A1 (en) * 2016-04-13 2017-10-19 广东盛泽康华生物医药有限公司 Tear collector

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