CN216560277U - A bear device and chemiluminescence analysis appearance for realizing chemiluminescence reaction - Google Patents

Abstract

The embodiment of the utility model provides a bearing device for realizing chemiluminescence reaction and a chemiluminescence analyzer, wherein the bearing device is at least provided with: a loading station for effecting contact of the reaction vessels with the carrier; a sample station for filling a sample to be tested into a reaction vessel; a reagent injection station for injecting reagents into the reaction vessels; a detection station for detecting a chemiluminescent signal in a reaction vessel; an unloading station for effecting separation of the reaction vessels from the carrier; the bearing device is provided with a temperature control component for maintaining the reaction container in a preset temperature range; the reaction vessel traverses the various stations on the carrier, wherein a chemiluminescent reaction is effected and detection of a chemiluminescent signal is accomplished during the course of the reaction vessel from contact to separation from the carrier. The bearing device provided by the embodiment of the utility model has the advantages that the structure can be simplified, the volume is favorably reduced, the bearing device is more suitable for the environment with narrow space, and the utilization rate can be improved.

Description

A bear device and chemiluminescence analysis appearance for realizing chemiluminescence reaction

The present application claims priority from chinese patent application entitled "carrying device and chemiluminescent analyzer for carrying out chemiluminescent reactions" filed at 20/8/2020, having application number 202021756906.3, which is incorporated herein by reference in its entirety.

Technical Field

The embodiment of the utility model relates to the field of medical equipment, in particular to a bearing device for realizing chemiluminescence reaction and a chemiluminescence analyzer.

Background

Various detection devices based on analysis of body fluids of the human body are on the market in full abundance, such as devices for routine tests of blood, devices for routine tests of urine, etc.

Such medical devices are currently developed for institutions such as clinical laboratories, commercial laboratories or medical examination centers in large hospitals. Therefore, the environment in which such devices are used needs to be faced with a large batch of test samples, and therefore, in order to meet the requirement of such a large batch of test samples, the existing devices are large in size, large in occupied area, heavy and inconvenient to carry.

In actual use, most emergency scenes also need the equipment for diagnostic analysis, however, the existing equipment is too large and cannot meet the requirement of narrow emergency environment space, and the detection samples in emergency are basically few, so that the utilization rate of large-scale equipment cannot be fully utilized.

SUMMERY OF THE UTILITY MODEL

The embodiment of the utility model provides a bearing device for realizing a chemiluminescence reaction and a chemiluminescence analyzer, and aims to solve the problems that large equipment in the prior art is difficult to adapt to narrow emergency environment space and low in utilization rate.

In order to solve the technical problem, the utility model is realized as follows:

the embodiment of the utility model provides a bearing device for realizing chemiluminescence reaction, which is at least provided with the following stations:

a loading station for effecting contact of reaction vessels with the carrier;

a sample station for filling a sample to be tested into the reaction vessel;

a reagent injection station for injecting reagents into the reaction vessels;

a detection station for detecting a chemiluminescent signal in the reaction vessel;

an unloading station for effecting separation of the reaction vessels from the carrier;

the bearing device is provided with a temperature control assembly, and the temperature control assembly is used for maintaining the reaction container in a preset temperature range;

the reaction container traverses the loading station, the sample station, the reagent injection station, the detection station and the unloading station on the bearing device, wherein the chemiluminescence reaction is realized and the detection of a chemiluminescence signal is completed in the process from the contact to the separation of the reaction container and the bearing device.

The embodiment of the utility model also provides a chemiluminescence analyzer which comprises the bearing device.

In the embodiment of the utility model, the carrying device is used for realizing chemiluminescence reaction, and at least a loading station, a sample station, a reagent injection station, a detection station and an unloading station are arranged on the carrying device. At the loading station, the reaction vessels are conveyed to the carrying device, and the contact between the reaction vessels and the carrying device can be realized; at a sample station, the reaction container can receive a sample to be detected, wherein the sample to be detected is sample liquid to be detected; at the reagent injection station, the reaction vessel may receive a detection reagent that chemically reacts with a sample to be detected; after the injection of the reagent is completed, the chemiluminescent signals in the reaction container can be detected and analyzed at a detection station; after the detection is completed, the counter-container can be moved to an unloading station and separated from the carrying device, so that the counter-container is separated from the carrying device. In the process of realizing the chemiluminescence reaction and completing the detection of the chemiluminescence signal, the reaction vessel is always positioned on the bearing device. Therefore, when the carrying device is used for carrying out chemiluminescence reaction and detection of chemiluminescence signals, the reaction container does not need to be transferred among different devices, so that the structure of the device is simplified, the size of the device is reduced, the device is more beneficial to adapting to the narrow and small use environment of an emergency environment space, and the utilization rate can be improved.

Drawings

In order to more clearly illustrate the technical solutions of the embodiments of the present invention, the drawings needed to be used in the description of the embodiments of the present invention will be briefly introduced below, and it is obvious that the drawings in the following description are only some embodiments of the present invention, and it is obvious for those skilled in the art that other drawings can be obtained according to these drawings without inventive labor.

FIG. 1 is a schematic view of a first carrier assembly according to an embodiment of the present invention;

FIG. 2 is a schematic view of a second carrier assembly according to an embodiment of the present invention;

FIG. 3 is a schematic view of a third carrier assembly according to an embodiment of the present invention;

FIG. 4 is a schematic diagram of a chemiluminescence analyzer in an embodiment of the utility model.

Detailed Description

The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are some, not all, embodiments of the present invention. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.

It should be appreciated that reference throughout this specification to "one embodiment" or "an embodiment" means that a particular feature, structure or characteristic described in connection with the embodiment is included in at least one embodiment of the present invention. Thus, the appearances of the phrases "in one embodiment" or "in an embodiment" in various places throughout this specification are not necessarily all referring to the same embodiment. Furthermore, the particular features, structures, or characteristics may be combined in any suitable manner in one or more embodiments.

The following describes a supporting device and a chemiluminescence analyzer for performing a chemiluminescence reaction according to the present invention in detail by way of specific examples.

The carrying device provided by the embodiment of the utility model can be used for carrying a reaction container used in light-activated chemiluminescence detection, and the reaction container is a cup-shaped container for containing a sample to be detected and a detection reagent, such as a cylindrical reaction cup. After a sample to be detected in the reaction container is mixed with a detection reagent, under the irradiation of exciting light emitted by the light detection system, a mixture in the reaction container receives light energy, then the mixture is subjected to chemical reaction and converted into chemical energy, the chemical energy is converted into light energy to emit light signals, the light detection system is used for detecting and analyzing the emitted light signals, and the health condition of a person corresponding to the sample to be detected can be judged according to an analysis result.

Therefore, the carrying device provided by the embodiment of the utility model has the function of ensuring that empty reaction containers can be smoothly loaded onto the carrying device in the whole detection process, and stably and rotatably move to corresponding sample filling, reagent filling and detection positions, and can be smoothly discharged from the carrying device into a waste article collecting device after detection is finished. The above processes can be completed on the carrying device.

In combination with the following specific description given by way of example, as shown in fig. 1, a carrying device for implementing a chemiluminescent reaction according to an embodiment of the present invention is provided with at least the following stations:

a loading station 101 for effecting contact of the reaction vessels with the carrier;

a sample station 102 for filling the reaction vessel with a sample to be tested;

a reagent injection station 103 for injecting reagents into the reaction vessels;

a detection station 104 for detecting a chemiluminescent signal in the reaction vessel;

an unloading station 105 for effecting separation of the reaction vessels from the carrier;

the bearing device is provided with a temperature control assembly, and the temperature control assembly is used for maintaining the reaction container in a preset temperature range;

the reaction vessels traverse the loading station 101, the sample station 102, the reagent injection station 103, the detection station 104 and the unloading station 105 on the carrier, wherein a chemiluminescent reaction is achieved and detection of a chemiluminescent signal is completed during the process from contact to separation of the reaction vessels from the carrier.

Specifically, the carrying device is used as a carrier of the reaction vessel, and can provide a plurality of stations for the reaction vessel, wherein the stations are working positions where the reaction vessel is located in different links in the chemiluminescence reaction and detection processes. Illustratively, the carrier may provide the reaction vessels with stations such as a loading station 101, a sample station 102, a reagent injection station 103, a detection station 104, and an unloading station 105.

At the loading station 101, the reaction vessels can be regularly transferred from their storage positions to the carrier by means of a vessel loading unit 201, such as a robot or a link mechanism, for a set period of time. In this case, empty, clean reaction vessels are placed on the carrier at the loading station.

A sample filling unit 202 may be disposed around the carrier for filling a sample to be tested, a sample moving arm assembly of the sample filling unit 202 may suck the collected sample to be tested from the sample rack bin, and after the sample moving arm assembly sucks the sample to be tested, the sample moving arm assembly moves to the sample station 102 to fill the sample to be tested into a reaction container located at the sample station 102.

Similar to the process of sample injection, a reagent injection unit 203 may be further provided at the periphery of the carrier for injecting a detection reagent. When the detection reagent is filled, the reaction container with the filled sample moves to the reagent filling station 103, and the detection reagent is obtained from the reagent tray by the reagent filling unit 203 and filled into the reaction container to form a mixture of the sample and the reagent. After the incubation reaction of the two is carried out for a set time, the reaction container is transferred to the detection station 104, the light detection system 204 located at the detection station 104 emits exciting light to irradiate the mixture, the sample and the reagent emit light in the chemical reaction process under the catalysis of the exciting light, and the light can be detected and analyzed by the detector at the detection station.

After the detection and analysis, the reaction containers need to be removed from the detection station 104 so that other reaction containers can reach the detection station 104 for detection, and the reaction containers containing the detected samples become medical wastes and need to be subjected to centralized harmless treatment as required. Therefore, the reaction container after the detection is moved to the unloading station 105, and at the unloading station 105, the reaction container can be unloaded from the carrier and discharged to a device for collecting and storing waste by a container unloading unit 205 (similar to the container loading unit, and may be a component such as a robot or a link mechanism) around the carrier. In addition, in order to ensure that the reaction vessel is at a proper reaction temperature in the reaction process, the temperature control assembly can be fixedly connected to the bearing device, the temperature control assembly can be fixedly arranged below the bearing device and corresponds to each station position of the reaction vessel, and the temperature control assembly can control the reaction speed by heating up or cooling down. For example, a PTC (Positive Temperature Coefficient) device may be used for heating, or a semiconductor chilling plate module may be used for cooling.

It can be seen that, in the embodiment of the present invention, when the carrying device is used to implement a chemiluminescent reaction, the reaction container is loaded onto the carrying device from the loading station, and after the sample filling, the reagent filling, and the sample detection are respectively completed at the sample station, the reagent filling station, and the detection station, in the whole process of being unloaded from the unloading station, although the reaction container is moved and switched at different stations, the reaction container is always on the carrying device, and the detection process can be completed without moving to other platforms or devices. The chemiluminescent reaction and the detection of the chemiluminescent signal can be completed from the contact of the reaction container and the bearing device to the separation of the reaction container and the bearing device.

It should be noted that the reaction containers may be moved between different stations by driving the carrying device itself, or by holding the carrying device still, and picking up the reaction containers by an external operating mechanism (e.g., a manipulator, a pneumatic chuck, etc.), so that the positions of the reaction containers are changed to reach different stations. The embodiment of the present invention is not limited to the moving manner of the reaction vessel.

In the embodiment of the utility model, the carrying device is used for realizing chemiluminescence reaction, and at least a loading station, a sample station, a reagent injection station, a detection station and an unloading station are arranged on the carrying device. The chemiluminescent reaction and each link of detection can be completed at different stations. Therefore, when the carrying device is used for carrying out chemiluminescence reaction and detection of chemiluminescence signals, the reaction container does not need to be transferred among different devices, so that the structure of the device is simplified, the size of the device is reduced, the device is more beneficial to adapting to the narrow and small use environment of an emergency environment space, and the utilization rate can be improved.

Optionally, the carrying device drives the reaction vessels to move together.

In particular, in one embodiment, the motor can be used to drive the carrier device to move along a predetermined linear or curved path in order to switch the reaction vessels between the various stations. For example, the motor may drive the carrier to rotate, and after a certain reaction vessel is loaded on the carrier, the reaction vessel may move synchronously with the carrier, and the reaction vessel may move to different stations at different times along with the rotation of the carrier. Compared with the reaction container moving realized by the cooperation of devices such as a mechanical arm and the like, the reaction container moves synchronously along with the bearing device, so that the volume of the device can be reduced, and the space occupancy rate can be reduced.

Optionally, with reference to fig. 1, the carrying means comprise a movable carrier 11;

from the arrival of the reaction containers at the loading station 101 to the departure from the unloading station 105, the reaction containers are in constant contact with the carrier 11.

In particular, as shown in fig. 1, in one embodiment, the carrying means may comprise a movable carrier 11. The carrier 11 can move along a predetermined path under the driving of a power device such as a motor, for example, the motor directly drives the carrier 11 to rotate through a speed reducing mechanism, or the motor drives the carrier 11 to move linearly through a rack and pinion mechanism. At the loading station 101, the reaction vessels are loaded onto the carrier 11, and when the carrier 11 is moved, the reaction vessels are brought together until they reach the unloading station 105 and are unloaded from the carrier. For example, in practical applications, the bearing member 11 may be a disk, the center of the disk is connected to a rotating shaft, and the motor may directly drive or drive the rotating shaft through a speed reducer to rotate the disk.

Optionally, referring to fig. 2, the carrier is connected to a light detection system 204, and the light detection system 204 includes an optical assembly disposed at the detection station 104 for transmitting excitation light to the reaction vessels and collecting light emitted by the reaction vessels during the reaction.

Specifically, as shown in FIG. 2, in one embodiment, a light detection system 204 is coupled to the carrier, and the light detection system 204 is disposed at the inspection station 104. Illustratively, the optical assembly may be fixed at the detection station 104 by adjusting the connection structure, so that the excitation light emitted from the optical assembly can irradiate on the sample in the reaction container at the detection station 104, and the light emitted from the reaction container can be collected and received by the optical assembly.

For example, a light source emitting excitation light may be disposed at the detection station 104, the light source irradiates the reaction container at the detection station, the light emitted by the reaction container during the reaction may be collected by using an optical fiber, and the collected light signal may be transmitted to a detector fixedly connected to the carrier or a detector disposed around the carrier. In addition, the detector can also integrate a light source and a detection analyzer, an optical fiber can be arranged at the detection station 104, the exciting light emitted by the light source is guided by the optical fiber to irradiate the reaction container at the detection station 104, the light emitted by the reaction container during reaction can be collected, received and transmitted to the detector through the optical fiber, and the arrangement position of the detector is more flexible and free.

Optionally, the light detection system 204 further comprises a detector optically coupled to the optical assembly, the detector receiving and evaluating the optical signal of the optical assembly.

Specifically, in one embodiment, the light detection system 204 may include an optical assembly for emitting excitation light, and the light detection system may integrate a detector optically coupled to the optical assembly, wherein after the optical signal of the optical assembly is irradiated onto the reaction container, the sample in the reaction container is excited by the excitation light to emit light, and the detector may collect and receive the light emitted from the sample, and analyze and evaluate the wavelength, frequency band, and the like of the light. The optical detection system 204 integrates the optical assembly with the detector and is coupled by optical coupling to help avoid the reduction of detection accuracy due to optical transmission loss caused by the separate arrangement of the two.

Alternatively, referring to fig. 3, the detector is disposed at a cover plate 12 stacked above the carrier 11.

In particular, as shown in fig. 3, in one embodiment, a cover plate 12 may be disposed above the carrier 11, and the cover plate 12 substantially conforms to the shape and size of the carrier 11, and may be slightly larger than the size of the carrier 11. The cover plate 12 can act as a screen for the carrier 11 and the reaction vessels on the carrier 11 from above. Therefore, when the sample in the reaction container and the reagent are subjected to chemical reaction and detection, the interference of ambient light can be avoided, and the accuracy of the detection result is improved as much as possible.

Alternatively, referring to fig. 3, the optical assembly and the detector are enclosed in a housing of the light detection system 204, and the light detection system 204 is aligned with the detection station 104 on the cover plate.

Specifically, as shown in FIG. 3, in one embodiment, the inspection may be performed at the inspection station 104 using an optical detection system 204 in which optical components are integrally packaged with the detector. Because this detection station 104 needs to detect a plurality of different samples of different moments, consequently, when bearing the movable part of thing 11, bear thing 11 and can drive the reaction vessel who contains different samples and remove to the detection station. At this point, the light detection system 204 may be secured to the cover 12 over the carrier 11, with the light detection system 204 aligned with the inspection station 104. It can be understood that, in this solution, the cover plate 12 does not need to move along with the bearing 11, the light detection system 204 and the cover plate 12 remain stationary, and the cover plate 12 is provided with a light inlet and outlet aperture corresponding to the position of the detection station 104. It can be seen that in this embodiment, the light detection system 204 can be integrated into the cover 12 of the carrier, which is more highly integrated and contributes to the reduction of the volume.

Optionally, referring to fig. 3, the carrier further comprises a side enclosure 13, and the side enclosure 13 is disposed along the circumferential direction of the carrier 11.

In particular, as shown in fig. 3, in one embodiment, the movable carrier 11 is usually moved by a driving mechanism connected thereto, and in this structure, the driving mechanism may be disposed below the carrier 11. The side coaming 13 can be arranged in the circumferential direction of the bearing member 11, on one hand, the coaming 13 can shield the driving mechanism to prevent the foreign matter from invading and blocking the operation of the driving mechanism, and on the other hand, the coaming 13 can also play a role of shielding the ambient light from the side surface surrounding the circumferential direction of the bearing member 11.

Alternatively, referring to fig. 3, the side enclosing plate 13 supports the cover plate 12 and is stacked above the carrier 11.

Specifically, as shown in fig. 3, in an embodiment, when the side wall 13 surrounds the enclosure in the circumferential direction of the carrier 11, the top of the side wall 13 may also be connected with the cover plate 12 by screws, so that the cover plate 12 is supported and fixed by the side wall 13, and the cover plate 12 is supported above the carrier 11 without specially designing a support structure for the cover plate 12.

Alternatively, referring to fig. 2, the side coaming 13 is provided with a loading channel 131 and an unloading channel 132;

at the loading station 101, the reaction containers are conveyed to the carrier 11 through the loading channel 131;

at the unloading station 105, the reaction vessels are discharged from the carrier 11 through the unloading channel 132.

Specifically, as shown in fig. 2, in an embodiment, in the case that the side enclosing plates 13 are provided on the circumference of the carrier 11, in order to ensure that the reaction vessels can be smoothly loaded and unloaded, loading channels 131 and unloading channels 132, for example, strip-shaped grooves, may be provided on the side enclosing plates 13. It should be noted that the widths of the loading channel 131 and the unloading channel 132 may be the same as the widths of the reaction vessels, and the extension directions of the loading channel 131 and the unloading channel 132 are both toward the carrier 11. At this time, the loading path 131 is located at the loading station 101, and the unloading path 132 is located at the unloading station 105. At the loading station 101, the container loading unit 201 applies a force to the reaction containers, sliding the reaction containers along the loading channel 131 onto the carrier 11. At the unloading station 105, the container unloading unit 205 applies a force to the reaction containers to slide the reaction containers along the unloading path 132, slide out of the carrier 11, and discharge the reaction containers that have completed the inspection.

Alternatively, referring to fig. 2, the loading station 101, the sample station 102, the reagent injection station 103, the detection station 104, and the unloading station 105 are disposed along the circumference of the carrier 11.

Specifically, as shown in fig. 2, in one embodiment, the loading station 101, the sample station 102, the reagent injection station 103, the detection station 104, and the unloading station 105 may be disposed along a circumference of the carrier 11. In practical applications, the stations may be arranged in a ring shape according to the shape of the carrier 11 and the detection control program. For example, the stations are arranged one after the other on the circumference of a circular carrier 11 or on different sides of a rectangular carrier 11. The arrangement order of the stations can be arranged in the order of the loading station 101, the sample station 102, the reagent injection station 103, the detection station 104 and the unloading station 105, or in other orders suitable for the control program. When the loading station 101, the sample station 102, the reagent injection station 103, the detection station 104 and the unloading station 105 are arranged, repeated actions and repeated paths of the reaction containers during switching among the stations are fewer, so that the detection time can be saved, and the detection efficiency can be improved.

Alternatively, referring to fig. 2, the loading station 101, the sample station 102, the reagent injection station 103, the detection station 104, and the unloading station 105 are spaced apart by a preset distance, wherein the preset distances are different from each other.

Specifically, as shown in fig. 2, in one embodiment, the distance between each two stations of the loading station 101, the sample station 102, the reagent injection station 103, the detection station 104 and the unloading station 105 can be determined based on the movement speed of the carrier and the time required for each link in the detection process, so that the distance between each two stations is not exactly the same.

For example, when the stations are arranged in sequence on the circumference of the circular carrier 11, the distance between the stations can be determined by controlling the central angle of the sector area formed between the stations, and when the central angles of the sectors formed by adjacent stations are different, the difference in distance can be realized. When the stations are arranged on different sides of the rectangular bearing part 11, the distance between the stations is designed and calculated according to the movement speed of the bearing part and the time required by each link in the detection flow.

Different preset distances among the stations are beneficial to ensuring that all the stations are coordinated and consistent at the same time, the continuity of the detection flow is kept, and the time waste caused by interruption and stop is avoided. For example, at a certain time, when the reaction container a is located at the unloading station 105, at the same time, there may be a reaction container B at the loading station 101, a reaction container C at the sample station 102, a reaction container D at the reagent injection station 103, and a reaction container E at the detection station 104, and each reaction container may be transferred to a different station according to the same flow steps to perform corresponding work. Therefore, the detection efficiency can be improved by designing the distance between the stations in advance.

Optionally, referring to fig. 2, the carrier 11 has a circular structure, and a plurality of accommodating chambers are disposed along a circumferential direction of the carrier 11, and the accommodating chambers are used for accommodating the reaction containers.

Specifically, in one embodiment, a disk may be used as the carrier 11, and a plurality of receiving pockets for receiving reaction vessels are formed along the circumferential direction of the disk. It should be noted that the number of the accommodating chambers can be determined according to the reaction time (i.e. the reaction time between the sample and the detection reagent (including the reaction time with the common liquid, if any) and the number of the single cycles, i.e. the total time consumed for the carrier 11 to move one reaction container to switch between the stations.

With reference to the illustration of fig. 2, a plurality of notches may be formed along the circumference of the disk, each notch may serve as a holding bin, the plurality of notches may be evenly distributed along the circumference of the disk, and each notch may be adapted to clamp the reaction vessels. When the bearing piece rotates, the reaction container clamped in the notch can be driven to move together. Receiving empty reaction vessels through the aforementioned loading channels when empty recesses are transferred to the loading station; when the notch carrying the reaction vessel moves to a sample station, a reagent injection station and a detection station, sample injection, reagent injection and detection can be respectively carried out; when the reaction vessel-carrying pocket is moved to the unloading station, the reaction vessel can be unloaded from the pocket of the carrier through the aforementioned unloading channel and discharged.

Alternatively, referring to fig. 3, the side enclosing plate 13 is a circular ring structure, and the bearing 11 is embedded in the inner ring of the side enclosing plate 13.

In particular, as shown in fig. 3, in one embodiment, when the aforementioned carrier 11 is a disk-shaped part, the reaction vessel can rotate on the disk with the disk. Correspondingly, the side wall 13 can be designed as a cylindrical part with a circular ring shape, and the bearing 11 can be embedded in the inner ring of the side wall 13. In this configuration, the carrier 11 rotates and also rotates the reaction vessel relative to the side wall 13, and the stations can be assigned based on the fixed side wall 13. In this structure, can realize the circulation of reaction vessel at each station and rotate, can compromise the structural dimension of device again.

Alternatively, referring to fig. 2, the loading station 101, the sample station 102, the reagent injection station 103, the detection station 104, and the unloading station 105 are arranged along a circumferential direction of the carrier 11;

the loading station 101, the sample station 102, the reagent injection station 103, the detection station 104 and the unloading station 105 form a first configuration line, a second configuration line, a third configuration line, a fourth configuration line and a fifth configuration line with the center of the carrier 11 respectively;

the first construction line and the second construction line form a first preset angle therebetween, the second construction line and the third construction line form a second preset angle therebetween, the third construction line and the fourth construction line form a third preset angle therebetween, and the fourth construction line and the fifth construction line form a fourth preset angle therebetween.

Specifically, in one embodiment, when the loading station 101, the sample station 102, the reagent injection station 103, the detection station 104, and the unloading station 105 are arranged along the circumferential direction of the carrier 11 in the case where the carrier 11 is circular, the loading station 101, the sample station 102, the reagent injection station 103, the detection station 104, and the unloading station 105 may be regarded as different mark positions on the side enclosing plate 13 around the carrier 11 with the stationary side enclosing plate 13 as a reference.

As shown in fig. 2, the loading station 101 may form a first configuration line with the center of the carrier 11, the sample station 102 may form a second configuration line with the center of the carrier 11, the reagent injection station 103 may form a third configuration line with the center of the carrier 11, the detection station 104 may form a fourth configuration line with the center of the carrier 11, and the unloading station 105 may form a fifth configuration line with the center of the carrier 11. Each two construction lines and the circumference of the carrier 11 enclose a sector area, and the central angle of each sector area can be used to determine the relative position of the corresponding two stations, such as a first preset angle α 1 between the first construction line and the second construction line, a second preset angle α 2 between the second construction line and the third construction line, a third preset angle α 3 between the third construction line and the fourth construction line, and a fourth preset angle α 4 between the fourth construction line and the fifth construction line, as shown in fig. 2. The preset angles are the same or different, and calculation can be designed according to the movement speed of the bearing part in the actual detection requirement and the time required by each link in the detection process, which is not limited in the embodiment of the utility model.

Optionally, referring to fig. 2, the sample station 102 includes a sample filling station 1021 and a sample diluting station 1022, the sample filling station 1021 and the sample diluting station 1022 being separated by a preset distance; and/or the presence of a gas in the gas,

the carrying device is provided with a plurality of reagent injection stations 103, and preset distances are arranged among the plurality of reagent injection stations 103.

Specifically, as shown in fig. 2, in one embodiment, the sample station 102 may specifically include a sample filling station 1021 and a sample diluting station 1022, and it should be noted that an empty reaction container may receive a sample drawn from the sample rack bin by the sample filling unit 202 at the sample filling station 1021, and may also receive a diluted sample drawn from a reaction container at the sample diluting station 1022 by the sample filling unit 202. The diluted sample at the sample diluting station 1022 is obtained by filling the sample at the sample filling station 1021 with the reaction container, moving to the reagent filling station 103 to add the diluent, and moving to the sample diluting station 1022 to distribute the empty reaction container to the sample filling station 1021. The sample filling station 1021 and the sample diluting station 1022 are also separated by a predetermined distance, and the design of the predetermined distance can be referred to the above description of the other stations, and will not be described herein again.

Similarly, the carrier may also be provided with a plurality of reagent injection stations 103 spaced apart by a predetermined distance. Each reagent injection station 103 can be used for filling one reagent, and the preset distances among the reagent injection stations 103 can also be referred to the description of other stations, which is not described herein again.

Optionally, the carrier is provided with more than three reagent injection stations 103, and the preset distances between each two reagent injection stations 103 are different from each other.

Specifically, in one embodiment, in order to match different detection items on the same carrier, more than three reagent injection stations 103 may be provided on the carrier, and the preset distances between the two reagent injection stations 103 are different from each other. Therefore, the injection stations of different reagents are independently designed in a split mode, the requirement that different reagents are injected at the same time can be met, namely different reagents can be added to different reagent injection stations aiming at samples to be detected, the requirements of different detection projects are met, and multi-project multifunctional detection can be achieved.

Optionally, a blending station is further arranged on the bearing device, and the blending station is used for uniformly mixing the sample to be tested in the reaction container with the reagent.

Particularly, in an embodiment, can also be provided with the mixing station on bearing the device, can remove to the mixing station after reaction vessel has added reagent, through the shake of device drive reaction vessel for the sample that awaits measuring and reagent misce bene, with the abundant that promotes chemical reaction, promote the testing result accuracy. It should be noted that, the blending process may also be completed in the moving process of the reaction container moving to the detection station after the reagent filling is completed, so as to save the waiting time.

Optionally, the carrying device further comprises a vibration assembly for controlling the reaction vessel to vibrate according to a preset frequency.

Particularly, in an embodiment, can set up the vibration subassembly in load-bearing device, but for example linear reciprocating's micro motor or ordinary rotating electrical machines, arrange the motor in the mixing station, through the motor drive reaction vessel according to the small amplitude swing of preset frequency or positive and negative rotation to with the sample that awaits measuring and reagent misce bene. It can be understood that, in the moving process that the reaction container moves to the detection station, the bearing part is controlled to rotate forward and backward according to the preset frequency to drive the reaction container to shake, so that the sample to be detected and the reagent are uniformly mixed.

Referring to fig. 4, an embodiment of the present invention further provides a chemiluminescence analyzer, which includes the carrying apparatus according to any one of the foregoing embodiments.

In the embodiment of the utility model, the chemiluminescence analyzer is used as a medical analysis instrument, and by applying the bearing device provided by any one of the embodiments, as the bearing device integrates the loading link of the reaction container, the filling link of the sample, the reagent injection link, the detection link and the unloading link of the container into one device, when the device is used for the chemiluminescence analyzer, the volume of the chemiluminescence analyzer can be effectively reduced, and the chemiluminescence analyzer can be more easily arranged and distributed in the environments of emergency desks, emergency rooms and the like with narrow spaces, and compared with the traditional large-scale equipment, the utilization rate can be effectively improved.

Optionally, referring to fig. 4, the chemiluminescence analyzer further comprises a container loading unit 201;

at the loading station 101, the container loading unit 201 loads the reaction containers to the carrier.

Specifically, as shown in fig. 4, in one embodiment, a fixed container loading unit 201 may be installed at the periphery of the carrier, and the moving path of the container loading unit 201 may cover the empty reaction container and the carrier. For example, a robot arm having a wide range of motion, an electrically driven link mechanism, or the like is used. At the loading station 101, the container loading unit 201 can load empty reaction containers onto a carrier for completing various work links.

Alternatively, referring to fig. 4, the container loading unit 201 includes: a load cradle 2011, a hub assembly 2012, and a transport assembly 2013;

the collecting and distributing assembly 2012 is connected to the loading support 2011, and the collecting and distributing assembly 2012 is used for orderly arranging the scattered reaction vessels;

the transfer assembly 2013 is used for transferring the reaction containers output by the collecting and distributing assembly 2012 to the loading station 101.

Specifically, as shown in fig. 4, in one embodiment, the container loading unit 201 may include: a load cradle 2011, a hub assembly 2012, and a transport assembly 2013. The loading rack 2011 is a support for connecting and supporting the collecting and distributing assembly 2012 and the conveying assembly 2013, the collecting and distributing assembly 2012 can be a housing driven by a motor, the housing contains a plurality of scattered reaction containers, and when the collecting and distributing assembly 2012 rotates, each reaction container is embedded into a groove on the housing according to a set direction, so that the reaction containers are orderly arranged so as to be sequentially output. As the collecting and distributing assembly 2012 rotates, the reaction vessels nested in the grooves enter the conveying assembly 2013, and the conveying assembly 2013 applies force to the reaction vessels, so that the reaction vessels are conveyed to the loading station 101 and can be loaded on the carrier.

Optionally, referring to fig. 4, the chemiluminescence analyzer further comprises a sample filling unit 202, wherein the sample filling unit 202 comprises a sample moving arm assembly 2021 and a sample rack bin 2022;

the sample rack chamber 2022 and the sample station 102 are both located on the movement path of the sample transfer arm assembly 2021, and the sample transfer arm assembly 2021 is used for transferring the sample of the sample rack chamber 2022 to the reaction container of the sample station 102.

Specifically, as shown in fig. 4, in one embodiment, a sample priming unit 202 may be mounted at the periphery of the carrier, and the sample priming unit 202 may include a sample arm assembly 2021 and a sample rack bin 2022. The sample rack chamber 2022 is used for temporarily storing samples to be tested collected by medical staff, and the samples to be tested can be contained in the sampling test tubes on the sample rack chamber 2022. Sample rack storage 2022 may include emergency sample rack storage proximate to the carrier and conventional sample rack storage slightly distal to the carrier. The path of motion of the sample arm assembly 2021 may cover the sample rack bin 2022 as well as the sample station 102. For example, a robot arm having a wide range of motion, an electrically driven link mechanism, or the like is used as the sample transfer arm assembly 2021. The sample moving arm assembly 2021 can move between the sample rack bin 2022 and the sample station 102 to fill the sample.

Optionally, referring to fig. 4, the sample filling unit further comprises a tip bin 2023;

the pipette tip bin is positioned on the movement path of the sample moving arm assembly, the sample moving arm assembly is used for replacing a new sampling needle from the pipette tip bin, and the pipette tip bin stores a plurality of sampling needles to be replaced.

Specifically, as shown in fig. 4, in one embodiment, in order to avoid the detection accuracy reduction and even the error caused by the cross contamination, a tip magazine 2023 may be provided for the sample filling unit 202, and the tip magazine stores a plurality of sampling needles to be replaced, and after each sample filling, the sample arm assembly 2021 may be moved to the tip magazine 2023 to automatically replace the new sampling needles in the tip magazine 2023.

Optionally, the sample rack bin is in communication with ambient air of the chemiluminescent analyzer.

In particular, in one embodiment, the sample rack compartment may be in communication with the ambient air of the chemiluminescent analyzer, for example, by opening the sample rack compartment within a protective housing of the chemiluminescent analyzer, or by providing a corresponding aperture in the sample rack compartment that is in communication with the ambient air. Therefore, the sample on the sample rack bin is at the ambient temperature, so that the chemical reaction interference caused by the temperature can be reduced, and the detection result is more accurate.

Optionally, referring to fig. 4, the chemiluminescence analyzer further comprises a reagent injection unit 203 comprising a reagent carrier 2031 and a reagent arm assembly 2032;

a plurality of reagent boxes are fixed on the reagent carrier 2031 and move along with the reagent carrier 2031, wherein at least one reagent is placed in each reagent box;

the reagent cartridge and the reagent injection station 103 are both located on the path of movement of the reagent arm assembly 2032, the reagent arm assembly 2032 being used to fill reagents in the reagent cartridge into the reaction vessels of the reagent injection station 103.

Specifically, as shown in fig. 4, in one embodiment, a reagent injection unit 203 may be mounted at the periphery of the carrier device, and the reagent injection unit 203 may include a reagent carrier 2031 and a reagent arm assembly 2032. The reagent carrier 2031 is used for storing a reagent that chemically reacts with the sample. The reagent arm assembly 2032 is used to aspirate and transfer reagents from the reagent carrier 2031 to the reaction vessels at the reagent injection station 103.

In particular, the reagent carrier 2031 may be a moving part, on which reagent carrier 2031 a plurality of reagent cartridges may be fixed, wherein each reagent cartridge has at least one reagent placed therein. When the reagent carrier 2031 is moved, the reagent cartridge may move with the reagent carrier 2031. The reagent cartridge and the reagent injection station 103 are both located on the path of movement of the reagent arm assembly 2032, it will be readily appreciated that the reagent arm assembly 2032 may sequentially draw different reagents from the reagent cartridge in batches and sequentially add the different reagents to the reaction vessels of the reagent injection station 103. It can be seen that the use of a single reagent arm assembly 2032 allows for the injection of a variety of different reagents, and also facilitates functional integration and reduced size.

Alternatively, referring to fig. 4, in case the carrying means comprises one carrier 11, the geometric centers of the carrier 11 and the reagent carrier 2031 are located on the same line.

Specifically, as shown in fig. 4, in an embodiment, when the carrier 11 is one, the geometric centers of the two parts of the carrier 11 and the reagent carrier 2031 may be located on the same straight line, that is, the carrier 11 and the reagent carrier 2031 are arranged in a line or a column, which may be determined by combining the functional layout of other units of the chemiluminescence analyzer, and this is not limited by the embodiment of the present invention.

Optionally, in case the carrying means comprises one carrier 11, the carrier 11 coincides with the geometrical center of the reagent carrier 2031.

In particular, in one embodiment, when the carrier 11 is one, the geometric centers of the two parts of the carrier 11 and the reagent carrier 2031 may coincide, for example, for a circular reagent carrier 2031 and a circular ring shaped carrier 11, the circular reagent carrier 2031 may be nested within the circular ring shaped carrier 11, i.e., in a concentric circular arrangement. In this configuration, the spatial position of the chemiluminescent analyzer where the reagent carrier is originally disposed can be vacated, and this part of the space can be compressed, which further contributes to further reducing the size of the chemiluminescent analyzer.

Optionally, referring to fig. 4, the light detection system 204 includes optical components disposed at the detection station 104 for transmitting excitation light to the reaction vessels and collecting light emitted by the reaction vessels during reaction.

Specifically, as shown in FIG. 4, in one embodiment, an optical detection system 204 is coupled to the carrier, and the optical detection system 204 is disposed at the inspection station 104. Illustratively, the optical assembly may be fixed at the detection station 104 by adjusting the connection structure, so that the excitation light emitted from the optical assembly can irradiate on the sample in the reaction container at the detection station 104, and the light emitted from the reaction container can be collected and received by the optical assembly.

For example, a light source emitting excitation light may be disposed at the detection station 104, the light source irradiates the reaction container at the detection station 104, light emitted by the reaction container during the reaction may be collected by using an optical fiber, and the collected light signal may be transmitted to a detector fixedly connected to the carrier or a detector disposed around the carrier. In addition, the detector can also integrate a light source and a detection analyzer, an optical fiber can be arranged at the detection station, the exciting light emitted by the light source is guided by the optical fiber to irradiate the reaction container at the detection station 104, the light emitted by the reaction container during reaction can be collected, received and transmitted to the detector through the optical fiber, and the arrangement position of the detector is more flexible and free.

Optionally, the light detection system 204 further comprises a detector optically coupled to the optical assembly, the detector receiving and evaluating the optical signal of the optical assembly.

Specifically, in one embodiment, the light detection system 204 may include an optical component for emitting the excitation light, and the light detection system 204 may integrate a detector optically coupled to the optical component, wherein after the optical signal of the optical component is irradiated onto the reaction container, the sample in the reaction container is excited by the excitation light to emit light, and the detector may collect the light emitted from the sample and analyze and evaluate the wavelength, frequency band, etc. of the light. The optical detection system 204 integrates the optical assembly with the detector and is coupled by optical coupling to help avoid the reduction of detection accuracy due to optical transmission loss caused by the separate arrangement of the two.

Optionally, referring to fig. 4, the chemiluminescent analyzer further includes a container unloading unit 205 including an unloading support 2051, an unloading lever 2052, and an unloading drive assembly 2053;

the unloading bracket 2051 is arranged at the unloading station 105, the unloading deflector rod 2052 is connected with the unloading bracket 2051 in a sliding manner, and the unloading deflector rod 2052 is provided with an unloading notch;

the unloading driving assembly 2053 drives the unloading shift lever 2052 to move linearly relative to the unloading support 2051, and drives the reaction vessel to move through the unloading notch, so as to unload the reaction vessel from the carrying device.

Specifically, as shown in fig. 4, in one embodiment, a fixed container unloading unit 205 may be installed at the periphery of the carrier, and the container loading unit 205 may include: an unload support 2051, an unload lever 2052, and an unload drive assembly 2053. The unloading support 2051 is a support for connecting and supporting the unloading shift lever 2052 and the unloading drive assembly 2053, the unloading support 2051 is aligned with the unloading station 105, the unloading shift lever 2052 is slidably connected with the unloading support 2015, and the unloading shift lever 2052 is provided with an unloading notch. The unloading driving assembly 2053 drives the unloading shift lever 2052 to move linearly relative to the unloading support 2051, and when the unloading shift lever 2052 reciprocates, the unloading notch can clamp the reaction vessel, drive the reaction vessel to move, and unload the reaction vessel from the bearing device.

Optionally, the chemiluminescence analyzer further comprises a suction and injection unit, wherein the suction and injection unit comprises a filling pump and a pipeline;

the filling pump is respectively communicated to the sample station and the reagent injection station through the pipelines.

Specifically, in one embodiment, the chemiluminescence analyzer can further comprise a suction-injection unit, and the suction-injection unit comprises a filling pump and a pipeline. The filling pump is used for generating a negative pressure environment, and is connected to the sample station and the reagent injection station after being communicated with the pipeline. For example, the pipeline may be communicated with a sample filling unit corresponding to the sample station for sucking the sample to be measured. The pipeline can be communicated with a reagent injection unit corresponding to the reagent injection station and used for sucking the reagent. The filling pump and the pipeline can be arranged at the bottom or other idle positions of the chemiluminescence analyzer, so that the movement of the moving part is prevented from being interfered.

Finally, it should also be noted that, herein, relational terms such as first and second, and the like may be used solely to distinguish one entity or action from another entity or action without necessarily requiring or implying any actual such relationship or order between such entities or actions. Also, the terms "comprises," "comprising," or any other variation thereof, are intended to cover a non-exclusive inclusion, such that a process, method, article, or terminal that comprises a list of elements does not include only those elements but may include other elements not expressly listed or inherent to such process, method, article, or terminal. Without further limitation, an element defined by the phrase "comprising an … …" does not exclude the presence of other like elements in a process, method, article, or terminal that comprises the element.

The above description is only for the purpose of illustrating the preferred embodiments of the present invention and is not to be construed as limiting the utility model, and any modifications, equivalents and improvements made within the spirit and principle of the present invention are intended to be included within the scope of the present invention.

The above description is only for the specific embodiments of the present invention, but the scope of the present invention is not limited thereto, and any person skilled in the art can easily conceive of the changes or substitutions within the technical scope of the present invention, and all the changes or substitutions should be covered within the scope of the present invention. Therefore, the protection scope of the present invention shall be subject to the protection scope of the claims.

Claims (32)

1. A carrying device for realizing chemiluminescence reaction is characterized in that at least the following stations are arranged on the carrying device:

a loading station for effecting contact of reaction vessels with the carrier;

a sample station for filling a sample to be tested into the reaction vessel;

a reagent injection station for injecting reagents into the reaction vessels;

a detection station for detecting a chemiluminescent signal in the reaction vessel;

an unloading station for effecting separation of the reaction vessels from the carrier;

the bearing device is provided with a temperature control assembly, and the temperature control assembly is used for maintaining the reaction container in a preset temperature range;

the reaction container traverses the loading station, the sample station, the reagent injection station, the detection station and the unloading station on the bearing device, wherein the chemiluminescence reaction is realized and the detection of a chemiluminescence signal is completed in the process from the contact to the separation of the reaction container and the bearing device.

2. The carrier as claimed in claim 1, wherein the carrier moves the reaction vessels together.

3. The carrier of claim 2, wherein the carrier comprises a movable carrier;

from the arrival of the reaction vessels at the loading station to the departure from the unloading station, the reaction vessels are in constant contact with the carrier.

4. The carrier device of claim 3, wherein the carrier device is coupled to a light detection system comprising an optical assembly disposed at the detection station for transmitting excitation light to the reaction vessels and collecting light emitted by the reaction vessels during the reaction.

5. The carrier device as recited in claim 4 wherein the light detection system further comprises a detector optically coupled to the optical assembly, the detector receiving and evaluating a light signal from the optical assembly.

6. The carrier as claimed in claim 5, wherein the detector is provided at a cover plate of the carrier stacked above the carrier.

7. The carrier as in claim 6 wherein the optical assembly and the detector are enclosed in a housing of the light detection system and the light detection system is aligned with the detection station on the cover plate.

8. The carrier according to claim 6 further comprising side enclosures arranged along a circumference of the carrier.

9. The carrier as claimed in claim 8 wherein the side enclosures support the deck stack above the carrier.

10. The carrier according to claim 8 wherein the side enclosures are provided with loading and unloading channels;

at the loading station, the reaction vessels are transported to the carrier through the loading channel;

at the unloading station, the reaction vessels are discharged from the carrier through the unloading channel.

11. The carrier as recited in claim 8,

the loading station, the sample station, the reagent injection station, the detection station and the unloading station are arranged along the circumference of the carrier.

12. The carrier as recited in claim 11,

preset distances are arranged among the loading station, the sample station, the reagent injection station, the detection station and the unloading station at intervals, wherein the preset distances are different from one another.

13. The carrier as recited in claim 12,

the bearing piece is of a circular structure, a plurality of containing bins are arranged in the circumferential direction of the bearing piece, and the containing bins are used for containing the reaction containers.

14. The carrier as recited in claim 13,

the side coaming is of a circular ring-shaped structure, and the bearing piece is embedded in the inner ring of the side coaming.

15. The carrier as recited in claim 14,

the loading station, the sample station, the reagent injection station, the detection station and the unloading station are arranged along the circumferential direction of the bearing piece;

the loading station, the sample station, the reagent injection station, the detection station and the unloading station form a first construction line, a second construction line, a third construction line, a fourth construction line and a fifth construction line with the circle center of the bearing piece respectively;

the first construction line and the second construction line form a first preset angle therebetween, the second construction line and the third construction line form a second preset angle therebetween, the third construction line and the fourth construction line form a third preset angle therebetween, and the fourth construction line and the fifth construction line form a fourth preset angle therebetween.

16. The carrying device according to any one of claims 1 to 15,

the sample station comprises a sample filling station and a sample diluting station, and the sample filling station and the sample diluting station are separated by a preset distance; and/or the presence of a gas in the gas,

the carrying device is provided with a plurality of reagent injection stations, and preset distances are arranged among the reagent injection stations at intervals.

17. The carrier according to claim 16 wherein there are more than three reagent injection stations, and the predetermined distances between each two reagent injection stations are different from each other.

18. The carrying device according to claim 16, further comprising a mixing station, wherein the mixing station is configured to uniformly mix the sample to be tested in the reaction vessel with the reagent.

19. The carrier as claimed in claim 18 further comprising a vibration assembly for controlling the reaction vessel to vibrate at a predetermined frequency.

20. A chemiluminescent analyzer comprising the carrier of any one of claims 1 to 19.

21. The chemiluminescent analyzer of claim 20 further comprising a container loading unit;

at the loading station, the container loading unit loads the reaction containers to the carrier.

22. The chemiluminescent analyzer of claim 21 wherein the container loading unit comprises: the loading device comprises a loading bracket, a distribution assembly and a conveying assembly;

the collecting and distributing assembly is connected with the loading bracket and is used for orderly arranging the scattered reaction vessels;

the conveying assembly is used for conveying the reaction containers output by the collecting and distributing assembly to the loading station.

23. The chemiluminescent analyzer of claim 20 further comprising a sample priming unit comprising a sample transfer arm assembly and a sample rack bin;

the sample rack bin and the sample station are both located on a movement path of the sample transfer arm assembly, and the sample transfer arm assembly is used for transferring samples in the sample rack bin to the reaction containers in the sample station.

24. The chemiluminescent analyzer of claim 23 wherein the sample fill unit further comprises a pipette tip magazine;

the pipette tip bin is positioned on the movement path of the sample moving arm assembly, the sample moving arm assembly is used for replacing a new sampling needle from the pipette tip bin, and the pipette tip bin stores a plurality of sampling needles to be replaced.

25. The chemiluminescent analyzer of claim 24 wherein the sample rack bin is in communication with ambient air of the chemiluminescent analyzer.

26. The chemiluminescent analyzer of claim 20 further comprising a reagent injection unit comprising a reagent carrier and a reagent arm assembly;

a plurality of reagent boxes are fixed on the reagent carriers and move along with the reagent carriers, wherein at least one reagent is placed in each reagent box;

the reagent box and the reagent injection station are both positioned on a motion path of the reagent arm assembly, and the reagent arm assembly is used for injecting the reagent in the reagent box into the reaction container of the reagent injection station.

27. The chemiluminescent analyzer of claim 26,

in case the carrier means comprises one carrier, the carrier is located on the same line as the geometric centre of the reagent carrier.

28. The chemiluminescent analyzer of claim 26,

in case the carrier means comprises one carrier, the carrier coincides with the geometric centre of the reagent carrier.

29. A chemiluminescent analyzer according to claim 20 wherein the carrier means is connected to a light detection system including an optical assembly disposed at the detection station for transmitting excitation light to the reaction vessel and collecting light emitted by the reaction vessel during reaction.

30. The chemiluminescent analyzer of claim 29,

the light detection system further includes a detector optically coupled to the optical assembly, the detector receiving and evaluating the optical signal from the optical assembly.

31. The chemiluminescent analyzer of claim 20 further comprising a container unloading unit comprising an unloading bracket, an unloading lever and an unloading drive assembly;

the unloading bracket is arranged at the unloading station, the unloading deflector rod is connected with the unloading bracket in a sliding manner, and the unloading deflector rod is provided with an unloading notch;

the unloading driving assembly drives the unloading deflector rod to move linearly relative to the unloading support, and the unloading notch drives the reaction container to move so as to unload the reaction container from the bearing device.

32. The chemiluminescent analyzer of claim 20 further comprising a suction and injection unit comprising a priming pump and tubing;

the filling pump is respectively communicated to the sample station and the reagent injection station through the pipelines.

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