CN216556517U - Concentrated preparation partial shipment device of biological cell - Google Patents
Concentrated preparation partial shipment device of biological cell Download PDFInfo
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- CN216556517U CN216556517U CN202123399899.3U CN202123399899U CN216556517U CN 216556517 U CN216556517 U CN 216556517U CN 202123399899 U CN202123399899 U CN 202123399899U CN 216556517 U CN216556517 U CN 216556517U
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Abstract
The utility model relates to a biological cell concentrated preparation split charging device, which belongs to the technical field of cell medicine split charging and comprises a separation cup, an intermediate bag and a product collecting bag, wherein the separation cup is communicated with the intermediate bag through a first branch pipeline, and the intermediate bag temporarily stores concentrated biological cells; the separation cup is communicated with a product collection bag through a second branch pipeline, and the product collection bag is used for subpackaging and collecting biological cells; the first branch pipeline is connected with a bypass pipeline, and the bypass pipeline drains waste liquid. The utility model has the advantages of integrated concentration, washing, preparation and split charging under closed conditions, no pollution to biological cell medicines, guarantee of the safety of biological cells, simple and convenient operation and time saving.
Description
Technical Field
The utility model relates to the technical field of cell medicine subpackage, in particular to a subpackage device for a biological cell concentrated preparation.
Background
The biological cell drug is a customized drug, which is customized according to the physical condition of a patient, and needs to be concentrated, prepared, and dispensed after cell culture. At present, cell preparation medicine concentration, preparation and subpackaging are generally carried out separately, and generally, cell medicine is concentrated first, then preparation liquid is added to the cell medicine through a manual device under A-grade clean environment, and then the cell medicine is subpackaged into a plurality of small bags for freezing storage.
At present, when cell biological medicines are subpackaged, an aseptic tube connecting machine is used for connecting a subpackage bag each time, after subpackage is finished, the bag of biological cell medicines is packaged and sealed by a heat sealing machine, then the aseptic tube connecting machine is used for connecting the next subpackage bag, and the process is circulated until subpackage is finished. Because the biological cell medicine has very high requirements on the sterile environment, pollution can not be generated, and the safety of the biological cell medicine for patients is ensured. However, the operation process of the split charging mode is complex, and the manual operation mode has an open environment, so that pollution is easy to occur, and finally biological cell medicines are scrapped. Therefore, it is a problem to be solved by those skilled in the art to provide a device capable of performing concentration, washing, preparation and dispensing operations under closed conditions.
Disclosure of Invention
This patent is just based on prior art's above-mentioned demand and proposes, and the technical problem that this patent will be solved provides a concentrated preparation partial shipment device of biological cell can once only accomplish concentration, washing, preparation and partial shipment operation under the confined condition to prevent that the biological cell medicine from taking place to pollute, guaranteed the security of biological cell medicine.
In order to solve the above problem, the technical scheme provided by the patent comprises:
a biological cell concentrated preparation split charging device is provided, the separation cup is communicated with an intermediate bag through a first branch pipeline, and the intermediate bag stores concentrated biological cells; the separation cup is communicated with a product collection bag through a second branch pipeline, and the product collection bag is used for subpackaging and collecting biological cells; the first branch pipeline is connected with a bypass pipeline, and the bypass pipeline drains waste liquid.
By adopting the technical scheme, the concentration, washing, preparation and subpackage operations of the biological cell medicine are finished in a closed environment, so that pollution can be prevented, and the safety of the biological cell medicine is ensured.
In a preferred embodiment of the present invention, the second branch line is provided in plurality and is in communication with a plurality of the product collection bags.
Through adopting above-mentioned technical scheme, a plurality of branch pipelines partial shipment simultaneously can improve the efficiency of partial shipment, practices thrift the time of partial shipment.
In a preferred embodiment of the present invention, the bypass line is connected to a waste bag, and the waste bag collects waste liquid generated in the concentration process and the washing process of the separation cup.
Through adopting above-mentioned technical scheme, collect the waste liquid bag with the waste liquid, centralized processing prevents the polluted environment.
In a preferred embodiment of the present invention, the first branch pipeline is communicated with a washing preparation pipeline through a first three-way joint, and the washing preparation pipeline circulates washing liquid and preparation liquid; the washing agent pipeline is communicated with the washing liquid container, a washing pump is further arranged in the washing liquid container, and the washing pump provides power for circulation of washing liquid in the washing agent pipeline.
By adopting the technical scheme, the cleaning solution and the preparation solution share one pipeline, so that the pipeline structure is simple, the complex pipeline structure is avoided, and the resources can be saved.
In a preferred embodiment of the present invention, the first branch pipeline and the second branch pipeline are communicated with a cup inlet pipeline through a second three-way joint, and the cup inlet pipeline is connected with the separation cup.
By adopting the technical scheme, the biological cells concentrated by the separation cup can flow into the middle bag through the first branch pipeline for storage, and the biological cells mixed with the washing liquid in the separation cup can also flow into the product collection bag, so that the concentration and washing in a closed environment are completed, and the biological cell medicines are prevented from being polluted by the external environment.
In a preferred embodiment of the present invention, an input end of the washing preparation pipeline is communicated with a preparation liquid container, a preparation pump is disposed in the preparation liquid container, and the preparation pump provides power for circulation of the preparation liquid in the washing preparation pipeline.
Through adopting above-mentioned technical scheme, the preparation liquid circulates to the product collection bag through washing preparation pipeline, first branch pipeline and second branch pipeline, accomplishes the partial shipment under the closed environment, avoids the pollution of open environment, guarantees the security of biological cell medicine.
The utility model provides a split charging device for a biological cell concentrated preparation, which has the following beneficial effects: the washing preparation pipeline, the first branch pipeline, the cup inlet pipeline and the second branch pipeline are communicated, so that concentration, washing, preparation and subpackaging are finished in a closed environment, safety in a biological cell medicine preparation and subpackaging process is guaranteed, an integrated preparation and subpackaging device is adopted, labor cost is saved, subpackaging efficiency is improved, and time is saved.
Drawings
FIG. 1 is a schematic view of a dispensing device for concentrated biological cell preparations according to the present invention;
description of reference numerals: 1. a detergent pipe; 2. a first three-way joint; 3. a first branch line; 4. a middle bag; 5. a bypass line; 6. a waste liquid bag; 7. a second three-way joint; 8. a cup inlet pipeline; 9. a separating cup; 10. a second branch line; 11. and (4) a product collecting bag.
Detailed Description
In order to make the objects, technical solutions and advantages of the embodiments of the present application clearer, the technical solutions in the embodiments of the present application will be clearly and completely described below with reference to the drawings in the embodiments of the present application, and it is obvious that the described embodiments are some embodiments of the present application, but not all embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present application.
For the purpose of facilitating understanding of the embodiments of the present application, the following description will be made in terms of specific embodiments with reference to the accompanying drawings, which are not intended to limit the embodiments of the present application.
The biological cell concentrated preparation subpackaging device provided by the specific embodiment is a device for integrally concentrating, washing, preparing and subpackaging biological cell medicines. The existing biological cell subpackaging device is complex in operation, needs manual operation of subpackaging bags, has an open environment, is easy to cause pollution of biological cell medicines, and affects the safety of the biological cell medicines. Therefore, it is a major difficulty in the art to provide a device capable of performing concentration, washing, formulation and dispensing under closed and contamination-free conditions.
As shown in FIG. 1, the concept of the present invention includes that a separation cup 9 is communicated with an intermediate bag 4, a waste liquid bag 6 and a product collection bag 11 through a first branch pipeline 3, a second branch pipeline 10 and a bypass pipeline 5, so that the concentration of biological cells is completed in a closed pollution-free environment, the concentrated biological cells flow into the intermediate bag 4, the waste liquid is discharged through the bypass pipeline 5, the washing liquid flows into the separation cup 9 from a washing preparation pipeline 1, the biological cells in the intermediate bag 4 flow into the separation cup 9 to be mixed, the generated waste liquid is discharged from the bypass pipeline 5, the preparation liquid flows into the product collection bag 11 from the washing preparation pipeline 1, and the biological cells mixed in the separation cup 9 flow into the product collection bag 11 to complete the sub-packaging process. The following examples are provided for this purpose in this detailed description.
The embodiment provides a biological cell concentrated preparation subpackaging device, referring to fig. 1, comprising a separation cup 9, an intermediate bag 4 and a product collecting bag 11, wherein the separation cup 9 is communicated with the intermediate bag 4 through a first branch pipeline 3, and the intermediate bag 4 stores concentrated biological cells.
Specifically, a biological cell sample is firstly circulated into a separation cup 9 through a washing preparation pipeline 1, a first three-way joint 2, a first branch pipeline 3 and a cup inlet pipeline 8, the separation cup 9 is used for concentrating biological cell liquid, the concentrated biological cells enter an intermediate bag 4 through the cup inlet pipeline 8, a second three-way joint 7 and the first branch pipeline 3, and the intermediate bag 4 stores the concentrated biological cells.
The first branch pipeline 3 is connected with a bypass pipeline 5, and the bypass pipeline 5 discharges waste liquid.
Specifically, the separation cup 9 concentrates the biological cell sap, and the waste liquid generated during the concentration process of the biological cell sap is discharged through the inlet cup pipeline 8, the first branch pipeline 3 and the bypass pipeline 5. Preferably, the bypass pipeline 5 is communicated with a waste liquid bag 6, the waste liquid bag 6 collects waste liquid generated in the cell liquid concentration process of the separation cup 9, the waste liquid is collected and treated uniformly, garbage classification can be achieved, environmental pollution is prevented, and damage of medical waste to the environment is reduced.
The washing preparation pipeline 1 is also communicated with a washing liquid container, a washing pump is further arranged in the washing liquid container, and the washing pump provides power for circulation of washing liquid in the washing preparation pipeline.
Specifically, the washing liquid container can be of a box structure, so that a large amount of washing liquid can be stored at one time, and the washing liquid container are prevented from being polluted due to frequent addition of the washing liquid from the outside and frequent opening of a box cover; the washing liquid container can also be a bag-shaped container, so that the washing liquid in the bag can be used up as soon as possible, the washing liquid is prevented from being discarded due to overdue storage time in the bag, and the waste of resources is reduced.
The washing liquid enters the separation cup 9 through the washing preparation pipeline 1, the first three-way joint 2, the first branch pipeline 3, the second three-way joint 7 and the cup inlet pipeline 8, the concentrated biological cells flow out of the middle bag 4 again and enter the separation cup 9 through the first branch pipeline 3, the second three-way joint 7 and the cup inlet pipeline 8, so that the concentrated biological cells are mixed with the washing liquid, and the biological cells mixed with the washing liquid are left in the separation cup 9. Waste liquid produced in the mixing process enters the waste liquid bag 6 through the cup inlet pipeline 8, the second three-way joint 7, the first branch pipeline 3 and the bypass management 5, and the waste liquid is treated in a centralized manner, so that the pollution to the environment is reduced.
The washing preparation pipeline 1 is also communicated with a preparation liquid container, a preparation pump is further arranged in the preparation liquid container, and the preparation pump provides power for circulation of preparation liquid in the washing preparation pipeline.
Specifically, the washing liquid container can be of a box body structure, so that a large amount of preparation liquid can be stored at one time, and the pollution of the preparation liquid and the preparation liquid container caused by frequent addition of the preparation liquid from the outside and frequent opening of a box cover can be prevented; the preparation liquid container can also be a bag-shaped container, so that the preparation liquid in the bag can be used up as soon as possible, the preparation liquid is prevented from being discarded due to overdue storage time in the bag, and the resource waste is reduced.
Preferably, the first branch pipeline 3 is further communicated with a washing preparation pipeline through a first three-way joint 2, and the washing preparation pipeline circulates washing liquid and preparation liquid. The structure complexity caused by excessive pipelines can be reduced, and in addition, compared with a plurality of pipelines, a single pipeline can save resources.
The preparation liquid enters a product collecting bag 11 through a washing preparation pipeline 1, a first three-way joint 2, a first branch pipeline 3 and a second branch management 10, and the product collecting bag 11 is used for subpackaging and collecting biological cell medicines. Preferably, the second branch pipeline 10 is provided with a plurality of branch pipelines, the product collecting bag 11 is also provided with a plurality of branch pipelines, and the plurality of branch pipelines 10 are communicated with the plurality of product collecting bags 11. Can improve the collection efficiency, save the collection time, and can enable the patient to use the biological cell medicine as soon as possible to cure the patient.
The first branch pipeline 3 and the second branch pipeline 10 are communicated with a cup inlet pipeline 8 through a second three-way joint 7, and the cup inlet pipeline 8 is connected with the separation cup 9. The biological cell sample and the washing liquid can be conveniently transferred into the separation cup 9, the preparation liquid can be directly transferred into the product collection bag 11, and the biological cells mixed with the washing liquid in the separation cup 9 can be transferred into the product collection bag 11; under the completely closed and sterile environment, the split charging of the biological cell concentrated preparation is completed, and the safety of the biological cell medicine is ensured.
Finally, the biological cells mixed with the washing liquid in the separation cup 9 enter the plurality of product collection bags 11 through the cup inlet pipeline 8 and the plurality of second branch pipelines 10 to be respectively mixed with the preparation liquid in each product collection bag 11, and the subpackaging process of the biological cells is completed.
By adopting the technical scheme, the concentration, washing, preparation and subpackaging operations of the biological cells are completed under the completely closed and pollution-free condition, no manual operation and open environment exist, pollution cannot be caused, and the rejection of biological cell medicines caused by pollution cannot be caused; on one hand, the safety of biological cell medicines is guaranteed, on the other hand, the preparation subpackaging efficiency of the biological cells is greatly improved, the operation is convenient, and the time is saved.
The above-mentioned embodiments, objects, technical solutions and advantages of the present application are described in further detail, it should be understood that the above-mentioned embodiments are merely exemplary embodiments of the present application, and are not intended to limit the scope of the present application, and any modifications, equivalent substitutions, improvements and the like made within the spirit and principle of the present application should be included in the scope of the present application.
Claims (7)
1. The utility model provides a concentrated preparation partial shipment device of biological cell, includes separation cup (9), middle bag (4) and product collection bag (11), its characterized in that:
the separation cup (9) is communicated with an intermediate bag (4) through a first branch pipeline (3), and the intermediate bag (4) stores concentrated biological cells;
the separation cup (9) is communicated with a product collection bag (11) through a second branch pipeline (10), and the product collection bag (11) is used for subpackaging and collecting biological cells;
the first branch pipeline (3) is connected with a bypass pipeline (5), and the bypass pipeline (5) drains waste liquid.
2. The split charging device for the concentrated preparation of biological cells as claimed in claim 1, wherein: the second branch pipeline (10) is provided with a plurality of product collecting bags (11) which are communicated with each other.
3. The split charging device for the concentrated preparation of biological cells as claimed in claim 1, wherein: the bypass pipeline (5) is communicated with a waste liquid bag (6), and the waste liquid bag (6) collects waste liquid generated in the concentration process and the washing process of the separation cup (9).
4. The split charging device for the concentrated preparation of biological cells as claimed in claim 1, wherein: the first branch pipeline (3) is communicated with a washing preparation pipeline (1) through a first three-way joint (2), and washing liquid and preparation liquid flow through the washing preparation pipeline (1).
5. The split charging device for the concentrated preparation of biological cells as claimed in claim 4, wherein: the first branch pipeline (3) and the second branch pipeline (10) are communicated with a cup inlet pipeline (8) through a second three-way joint (7), and the cup inlet pipeline (8) is connected with the separation cup (9).
6. The split charging device for the concentrated preparation of biological cells as claimed in claim 5, wherein: the washing agent pipeline (1) is communicated with a washing liquid container, a washing pump is arranged in the washing liquid container, and the washing pump provides power for the circulation of washing liquid in the washing agent pipeline.
7. The split charging device for the concentrated preparation of biological cells as claimed in claim 5, wherein: the input end of the washing preparation pipeline (1) is communicated with a preparation liquid container, a preparation pump is arranged in the preparation liquid container, and the preparation pump provides power for circulation of preparation liquid in the washing preparation pipeline.
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| Application Number | Priority Date | Filing Date | Title |
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| CN202123399899.3U CN216556517U (en) | 2021-12-30 | 2021-12-30 | Concentrated preparation partial shipment device of biological cell |
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| CN202123399899.3U CN216556517U (en) | 2021-12-30 | 2021-12-30 | Concentrated preparation partial shipment device of biological cell |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN116062218A (en) * | 2022-12-28 | 2023-05-05 | 中博瑞康(上海)生物技术有限公司 | Full-automatic cell preparation split charging method and device thereof |
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2021
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN116062218A (en) * | 2022-12-28 | 2023-05-05 | 中博瑞康(上海)生物技术有限公司 | Full-automatic cell preparation split charging method and device thereof |
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