CN216484820U - On-off valve group type preparation automatic sample injector - Google Patents

Abstract

The utility model discloses an on-off valve group type automatic sample preparation injector, which comprises an on-off valve group, an electric high-pressure six-way valve and an injection pump mechanism, wherein the electric high-pressure six-way valve is connected with the injection pump mechanism; the on-off valve group comprises an eleven-position normally closed two-way on-off valve and a one-position normally open two-way on-off valve, and is fixedly connected through two valve substrates; the electric high-pressure six-way valve comprises a high-pressure six-way valve and an electric switching device, wherein the high-pressure six-way valve is externally provided with 6 interfaces and has 2 working states of sampling and sample introduction; the injection pump mechanism, comprising: an injector; a two-position three-way electromagnetic valve; the upper end of the injector stepping motor is provided with a synchronous belt wheel; the upper end of the injector screw rod is provided with a synchronous belt pulley, and a screw rod nut is arranged on the shaft of the injector screw rod; the injector stepping motor and the injector lead screw are connected through a synchronous belt. The utility model uses the electromagnetic valve of the injector and the quantitative ring to suck the sample, and can effectively avoid the sample pollution and residue; meanwhile, the functions of large sample injection amount, continuous sample injection and the like can be realized.

Description

On-off valve group type preparation automatic sample injector

Technical Field

The utility model discloses an on-off valve group type automatic sample preparation injector, which can realize the function of continuous sample injection with large sample injection amount, and particularly relates to an automatic sample injector in the field of liquid chromatogram preparation application.

Background

For the field of preparing liquid phase, the sample injection is characterized by less sample types and large sample injection amount; the sample injection mode mainly adopts two types of a manual sample injector and an automatic sample injector; with the advancement of technology, the demand of users for automation is higher and higher, and the demand of auto-samplers is also higher and higher. The existing automatic equipment integrating sample introduction and collection in the market at present and equipment such as a sample introduction pump or an analysis sample introduction device used in combination with a system can realize that the single sample amount is 500 mu l-20ml and the continuous sample introduction is few.

SUMMERY OF THE UTILITY MODEL

The utility model aims to provide an on-off valve group type preparation automatic sample injector which is simple in movement mechanism and can carry out continuous sample injection with larger sample injection amount.

An on-off valve group type automatic sample preparation injector mainly comprises an on-off valve group, an electric high-pressure six-way valve, an injection pump mechanism and a sample test tube rack.

The on-off valve group mainly comprises eleven normally closed two-way on-off valves and one normally open two-way on-off valve, wherein the two valve substrates are fixedly connected, COM ports of all the two on-off valves are connected with a common channel port of the substrate, an NC port of the normally closed on-off valve is connected with a sample port, an NO port of the normally open on-off valve is connected with a cleaning liquid port, and a sample port connecting pipeline is inserted into a sample test tube.

The electric high-pressure six-way valve mainly comprises a high-pressure six-way valve and an electric switching device, wherein the electric switching device mainly comprises a stepping motor, a speed-changing belt wheel and a photoelectric switch and is mainly used for precisely rotating back and forth by 60 degrees so as to drive the six-way valve to switch; the high-pressure six-way valve is externally provided with 6 interfaces, and has 2 working states of sampling and sample introduction. The automatic sample injector is characterized in that a second interface and a fifth interface of the high-pressure six-way valve are connected with a quantitative ring, a fourth interface is connected with an outlet of a liquid chromatogram infusion pump, a third interface is connected with an inlet end of a chromatographic column, a sixth interface is connected with a public channel of an on-off valve group substrate, and a first interface is connected with an NC (numerical control) port of an electromagnetic valve on an injection pump. When the automatic sampler is in a sampling state, the connection relationship of 6 interfaces in the automatic sampler is as follows: the first interface is communicated with the second interface, the third interface is communicated with the fourth interface, and the fifth interface is communicated with the sixth interface. The sample is sucked into the quantitative ring by an injection pump, and the liquid chromatography main flow path is directly fed with the mobile phase into the chromatographic column by an infusion pump. When the automatic sample injector is in a sample injection state, the connection relationship of the 6 interfaces in the automatic sample injector is as follows: the first interface is communicated with the sixth interface, the second interface is communicated with the third interface, the fourth interface is communicated with the fifth interface, and the infusion pump brings the sample in the quantitative ring into the chromatographic column.

The injection pump mechanism, essentially comprising: an injector; the COM port of the two-position three-way electromagnetic valve is connected with the injector, the NC port is connected with a common channel of the valve base plate of the on-off valve group, and the NO port is connected with the waste liquid port; the upper end of the injector stepping motor is provided with a synchronous belt wheel; the upper end of the injector screw rod is provided with a synchronous belt pulley, and the shaft of the injector screw rod is provided with a screw rod nut. The injector stepping motor is connected with the injector lead screw through a synchronous belt, and when the injector stepping motor rotates, a lead screw nut on the injector lead screw is driven to move up and down through transmission of the synchronous belt.

The sample test tube rack can be used for holding 24 sample test tubes with the capacity of 100 ml.

The utility model relates to an on-off valve group type preparation automatic sample injector, which has the advantages that: the sample is sucked by using the electromagnetic valve of the injector and the quantitative ring, so that the pollution and the residue of the sample can be effectively avoided; meanwhile, the functions of large sample injection amount, continuous sample injection and the like can be realized.

Drawings

The accompanying drawings, which are included to provide a further understanding of the utility model and are incorporated in and constitute a part of this specification, illustrate embodiments of the utility model and together with the description serve to explain the principles of the utility model. In the drawings:

FIG. 1 is a schematic view of the overall flow path of the present invention.

Fig. 2 is a schematic view of the overall structure of the present invention.

Fig. 3 is a schematic diagram of a switching valve block of the present invention.

Fig. 4 is an exploded view of the electric high pressure six-way valve of the present invention.

Fig. 5 is a front view of the electric high-pressure six-way valve of the present invention.

Fig. 6 is a rear view of the electric high-pressure six-way valve of the present invention.

Fig. 7 is a schematic view of the injection pump mechanism of the present invention.

Fig. 8 is a schematic of an exemplary sample 1 sampling process of the present invention.

FIG. 9 is a schematic view of the sample injection process of the present invention.

The specific reference numbers in the figures are as follows:

1. make-and-break valve group 2 and electric high-pressure six-way valve

3. Injection pump mechanism 4, sample test-tube rack

110. On-off valve base plate 111, common channel

112. Sample inlet 113 and cleaning liquid port

120. Normally closed electromagnetic on-off valve 130 and normally open electromagnetic on-off valve

210. High-pressure six-way valve 220 and electric switching device

211. First interface 212 and second interface

213. Third interface 214 and fourth interface

215. Fifth interface 216 and sixth interface

217. Dosing ring 218, infusion pump

219. Chromatographic column 221 and stepping motor

222. Variable speed belt wheel set 223 and photoelectric switch

310. Injector 320 and two-position three-way electromagnetic valve

330. Stepping motor 331 and synchronous pulley for syringe

332. Syringe screw 333, synchronous pulley

334. Lead screw nut 335, synchronous belt

Detailed Description

The utility model discloses a novel on-off valve group type automatic sample preparation injector. As shown in fig. 1, which is a schematic view of an overall flow path, and fig. 2, which is a schematic view of an overall structure, the auto-sampler mainly includes: the device comprises an on-off valve group 1, a high-voltage electric six-way valve 2, an injection pump mechanism 3 and a sample test tube rack 4.

As shown in fig. 3, the low pressure on-off valve block 1 includes:

the on-off valve base plate 110 is provided with a common channel 111, a sample inlet 112 and a cleaning liquid port 113, the on-off valve base plate 110 is further provided with eleven normally closed electromagnetic on-off valves 120 provided with COM and NC ports and one normally closed electromagnetic on-off valve 130 provided with COM and NO ports, the COM ports of all two-way electromagnetic valves are connected with the common channel 111 of the on-off valve base plate 110, the NC port of the normally closed two-way electromagnetic on-off valve is connected with the sample port 112, and the NO port of the normally open two-way electromagnetic on-off valve is connected with the cleaning liquid port 113;

as shown in fig. 4, 5 and 6, the electric high-pressure six-way valve 2 includes:

the high-pressure six-way valve 210 and the electric switching device 220 are mainly composed of a stepping motor 221, a variable speed belt wheel set 222 and a photoelectric switch 223, and are mainly used for precisely rotating back and forth for 60 degrees so as to drive the high-pressure six-way valve 210 to switch; the high-pressure six-way valve 210 is externally provided with 6 interfaces, and has 2 working states of sampling and sample introduction. Viewed from the outside, the second port 212 and the fifth port 215 of the high-pressure six-way valve 210 are connected with a dosing ring 217, the fourth port 214 is connected with the outlet of an infusion pump 218 of the liquid chromatography, the third port 213 is connected with the inlet end of a chromatographic column 219, the sixth port 216 is connected with the common channel 111 of the on-off valve group, and the first port 211 is connected with the NC port of a two-position three-way electromagnetic valve 320 on the injection pump.

As shown in fig. 7, the injection pump mechanism 3 includes:

a syringe 310; a two-position three-way electromagnetic valve 320, wherein a COM port of the two-position three-way electromagnetic valve is connected with the injector 310, an NC port is connected with the common channel 111 of the on-off valve substrate 110, and NO is connected with waste liquid; an injector stepping motor 330, the upper end of which is provided with a synchronous belt wheel 331; the injector screw 332 is provided with a timing pulley 333 at its upper end and a screw nut 334 on its shaft. The syringe stepping motor 330 and the syringe lead screw 331 are coupled by a timing belt 335, and when the syringe stepping motor 330 rotates, a lead screw nut 334 of the syringe lead screw 332 is driven up and down by the timing belt 335, thereby driving the syringe 310 to suck and discharge liquid.

Fig. 8 is a schematic flow diagram of a sampling process of an exemplary sample 1 according to the present invention. When the automatic sampler is in a sampling state, the connection relationship of the 6 internal interfaces is as follows: the first port 211 communicates with the second port 212, the third port 213 communicates with the fourth port 214, and the fifth port 215 communicates with the sixth port 216. The sample is drawn into the dosing ring 217 by a syringe pump, while the main flow path of the liquid chromatography, the infusion pump 218, feeds the mobile phase directly into the column 219.

FIG. 9 is a schematic view of a flow path in the sample injection process of the present invention. When the automatic sample injector is in a sample injection state, the connection relationship of the 6 internal interfaces is as follows: the first port 211 is in communication with the sixth port 216, the second port 212 is in communication with the third port 213, the fourth port 214 is in communication with the fifth port 215, and the infusion pump 218 is configured to bring the sample in the quantification ring 217 into the chromatography column 219.

The working steps and the principle of the utility model are as follows:

when the autosampler is in the sampling step: the two-position three-way electromagnetic valve, namely the NO port of the electromagnetic valve of the injector, is opened, and the push rod of the injector is pushed up to the top end. And the electric high-pressure six-way valve is adjusted to a sampling state, and the on-off valve group is switched to a sample hole position. Then opening an NC port of an injector electromagnetic valve, and enabling an injector push rod to move downwards to suck a quantitative sample from a sample test tube into a quantitative ring; thereafter, the injector solenoid valve NO port is opened, and the injector returns to the initial position to discharge the waste liquid.

When the autosampler is in the sample injection step: the electric high-pressure six-way valve is switched to a sample feeding state, and the sample in the quantitative ring is brought into the chromatographic system by the infusion pump.

And then, if different samples need to be fed, the sampling step needs to be repeated, and only the on-off valve group is switched to a cleaning solution hole position, and after a common channel is cleaned by the cleaning solution, the next sample is fed.

Claims (6)

1. The utility model provides an automatic injector of on-off valve group formula preparation which characterized in that: the automatic sample injector comprises an on-off valve group, an electric high-pressure six-way valve and an injection pump mechanism;

the on-off valve group comprises eleven-position normally closed two-way on-off valves and one-position normally open two-way on-off valves, the eleven-position normally closed two-way on-off valves and the one-position normally open two-way on-off valves are fixedly connected through two valve base plates, COM ports of all the two-way on-off valves are connected with a common channel port of the base plate, NC ports of the normally closed on-off valves are connected with a sample port, NO ports of the normally open on-off valves are connected with a cleaning liquid port, and a sample port connecting pipeline is inserted into a sample test tube;

the electric high-pressure six-way valve comprises a high-pressure six-way valve and an electric switching device, wherein the high-pressure six-way valve is externally provided with 6 interfaces and has 2 working states of sampling and sample introduction;

the injection pump mechanism, comprising: an injector; the COM port of the two-position three-way electromagnetic valve is connected with the injector, the NC port is connected with a common channel of the valve base plate of the on-off valve group, and the NO port is connected with the waste liquid port; the upper end of the injector stepping motor is provided with a synchronous belt wheel; the upper end of the injector screw rod is provided with a synchronous belt pulley, and the shaft of the injector screw rod is provided with a screw rod nut; the injector stepping motor and the injector lead screw are connected through a synchronous belt.

2. The on-off valve-set preparation autosampler of claim 1, wherein: the electric switching device consists of a stepping motor, a variable speed belt wheel and a photoelectric switch and drives the high-pressure six-way valve to switch.

3. The on-off valve-set preparation autosampler of claim 1, wherein: the automatic sample injector is characterized in that a second interface and a fifth interface of the high-pressure six-way valve are connected with a quantitative ring, a fourth interface is connected with an outlet of a liquid chromatogram infusion pump, a third interface is connected with an inlet end of a chromatographic column, a sixth interface is connected with a public channel of an on-off valve group substrate, and a first interface is connected with an NC (numerical control) port of an electromagnetic valve on an injection pump.

4. The on-off valve-set preparation autosampler of claim 1, wherein: when the automatic sampler is in a sampling state, the connection relationship of 6 interfaces in the automatic sampler is as follows: the first interface is communicated with the second interface, the third interface is communicated with the fourth interface, and the fifth interface is communicated with the sixth interface.

5. The on-off valve-set preparation autosampler of claim 1, wherein: when the automatic sample injector is in a sample injection state, the connection relationship of the 6 interfaces in the automatic sample injector is as follows: the first interface is communicated with the sixth interface, the second interface is communicated with the third interface, and the fourth interface is communicated with the fifth interface.

6. The on-off valve-set preparation autosampler of any of claims 1-5, wherein: the autosampler further includes a sample tube rack.

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