CN216333593U - Storage device for PDX model management - Google Patents
Storage device for PDX model management Download PDFInfo
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- CN216333593U CN216333593U CN202122823628.XU CN202122823628U CN216333593U CN 216333593 U CN216333593 U CN 216333593U CN 202122823628 U CN202122823628 U CN 202122823628U CN 216333593 U CN216333593 U CN 216333593U
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Abstract
The utility model discloses a storage device for PDX model management, which relates to the field of PDX model management and comprises a box body, a storage box and a storage box, wherein the box body comprises an operation box, an observation box and a middle section connecting box; the sealing mechanism comprises a first sealing cover door arranged on the observation box through a hinge and a sealing assembly arranged on the middle section connecting box; and the conveying mechanism is arranged inside the observation box and is used for conveying the PDX model to the operation box. According to the storage device for managing the PDX model, the PDX model to be stored is prevented from being arranged on the top sliding table through the feeding cage, the temperature, humidity and air environment required by the observation box are set through the central centralized controller, when the PDX model needs to be subjected to anatomical observation, the second sealing cover door is opened, the driving cylinder drives the top sliding table to move to the operation box through the driving rod, the top sliding table is not in contact with the outside to guarantee sterility, an experimenter can operate the PDX model through the glove operation opening, the reliability of an experiment is guaranteed, and meanwhile, the experimenter can conveniently operate the storage device.
Description
Technical Field
The utility model relates to the field of PDX model management, in particular to a storage device for PDX model management.
Background
To meet the need for improved tumor models, the use of cancer cell lines has been currently shifted to patient-derived xenogeneic (PDX) in vivo animal models. The PDX model is a powerful preclinical tumor model, and can retain histopathology, genomics and transcriptomics, tumor heterogeneity, drug response and other characteristics of a patient's tumor. Patient-derived xenografts were generated by direct transplantation of tumor samples from cancer patients into immunocompromised mice.
In the PDX model management and storage process, a common breeding box is usually used for breeding, so that the sterility of the environment and the stable survival of the PDX model cannot be guaranteed.
SUMMERY OF THE UTILITY MODEL
The utility model aims to provide a storage device for PDX model management, which overcomes the defects of the prior art, ensures the existence of a PDX model by controlling the temperature, the humidity and the air environment in the device through a central centralized controller, ensures the sterile environment in the device by driving a cylinder to drive a top sliding table to move, and has the characteristics of convenience in operation, improvement on experimental accuracy and guarantee of the sterile environment.
In order to solve the problems, the technical scheme adopted by the utility model is as follows:
a storage device for PDX model management comprises
The box body comprises an operation box, an observation box and a middle section connecting box, wherein transparent observation windows are arranged at the centers of the outer walls of the two sides of the operation box, a connecting port for connecting other external equipment is fixedly arranged at the top of the operation box, the middle section connecting box is arranged between the operation box and the observation box, and the connecting part is subjected to sealing treatment;
the sealing mechanism comprises a first sealing cover door arranged on the observation box through a hinge and a sealing assembly arranged on the middle section connecting box;
and the conveying mechanism is arranged inside the observation box and is used for conveying the PDX model to the operation box.
Further, the central control ware of control operation box and inside humiture of observation box and air circumstance is installed at the operation box top, the gloves operation mouth of making things convenient for the experimenter to operate is installed to transparent observation window circular gap department.
Further, the operation box and the observation box are both subjected to aseptic sealing treatment.
Furthermore, transparent glass convenient for observation is installed at the center of the first sealing cover door, and a plurality of auxiliary closers are installed around the outer side of the first sealing cover door.
Further, the seal assembly comprises a second seal cover door and a top sliding rail, the top sliding rail is arranged at the top of the middle section connecting box, the second seal cover door is connected with the top sliding rail through a side sliding rail, an auxiliary handle which is convenient to open and close is installed on one side of a telescopic pipe with a control stroke at the bottom of the second seal cover door, and the other end of the telescopic pipe is installed on one side of the middle section connecting box through a mounting seat.
Further, conveying mechanism is including driving actuating cylinder and top slip table, it installs in observation box one side and the output passes through the actuating lever and is connected bottom the top slip table to drive actuating cylinder.
Further, top slip table bottom is equipped with the spout and installs inside the observation box through the bottom sprag seat.
Compared with the prior art, the utility model has the following beneficial effects:
the utility model is convenient for experimenters to carry out operations such as dissection on the PDX model through the transparent observation window and the glove operation opening, and is more convenient.
According to the utility model, the temperature and humidity and the air environment in the device are controlled by the central centralized controller, so that the existence of the PDX model is ensured, meanwhile, the top sliding table is driven to move by the driving cylinder, the sterile environment in the device is ensured, and the experimental accuracy is improved.
The utility model has the characteristics of convenient operation, improved experimental accuracy and ensured sterile environment.
Drawings
FIG. 1 is a schematic view of a first perspective external overall structure of a storage device for PDX model management according to the present invention;
FIG. 2 is a schematic view of a second perspective external overall structure of the storage device for PDX model management according to the present invention;
FIG. 3 is a schematic external side view of a PDX model management storage device according to the present invention;
fig. 4 is a schematic internal sectional view of a storage apparatus for PDX model management according to the present invention.
In the figure: 100. a box body; 101. an operation box; 102. an observation box; 103. a transparent viewing window; 104. a glove operating opening; 105. a central centralized controller; 106. a connecting port; 107. the middle section is connected with the box; 200. a sealing mechanism; 201. a first seal cover door; 202. an auxiliary closer; 203. a second hermetically sealed lid door; 204. a telescopic pipe; 205. a top slide rail; 206. an auxiliary handle; 300. a conveying mechanism; 301. a driving cylinder; 302. a top sliding table; 303. a drive rod; 304. a bottom support seat.
Detailed Description
In order to make the technical means, the creation characteristics, the achievement purposes and the effects of the utility model easy to understand, the utility model is further described with the specific embodiments.
In the description of the present invention, it should be noted that the terms "upper", "lower", "inner", "outer", "front", "rear", "both ends", "one end", "the other end", and the like indicate orientations or positional relationships based on those shown in the drawings, and are only for convenience of description and simplicity of description, but do not indicate or imply that the referred device or element must have a specific orientation, be constructed in a specific orientation, and be operated, and thus, should not be construed as limiting the present invention. Furthermore, the terms "first" and "second" are used for descriptive purposes only and are not to be construed as indicating or implying relative importance.
In the description of the present invention, it is to be noted that, unless otherwise explicitly specified or limited, the terms "mounted," "disposed," "connected," and the like are to be construed broadly, such as "connected," which may be fixedly connected, detachably connected, or integrally connected; can be mechanically or electrically connected; they may be connected directly or indirectly through intervening media, or they may be interconnected between two elements. The specific meanings of the above terms in the present invention can be understood in specific cases to those skilled in the art.
Referring to FIGS. 1-4, the present invention is a storage device for PDX model management, comprising
The box body 100 comprises an operation box 101, an observation box 102 and a middle section connecting box 107, wherein transparent observation windows 103 are arranged at the centers of the outer walls of the two sides of the operation box 101, a connecting port 106 for connecting other external equipment is fixedly arranged at the top of the operation box 101, the middle section connecting box 107 is arranged between the operation box 101 and the observation box 102, and the connecting position is sealed;
a closing mechanism 200 including a first seal cover door 201 provided on the observation box 102 by a hinge and a closing member mounted on the middle section connection box 107;
and a conveying mechanism 300 which is installed inside the observation box 102 and conveys the PDX model into the operation box 101.
In use, the PDX model to be stored is secured to the top slide 302 by the cage, with the second gland door 203 closed, the observation box 102 closed, while closing the first hermetically-sealed lid door 201, and further increasing the hermeticity of the observation box 102 by the auxiliary closer 202, the temperature, humidity and air environment required by the observation box 102 are set by the central controller 105, the activity and sterile environment of the PDX model are ensured, when needs dissect the observation to the PDX model, open second sealing cover door 203, start and drive actuating cylinder 301, it moves to control box 101 to drive actuating cylinder 301 through actuating lever 303 drive top slip table 302, it is aseptic not guaranteed with external contact, the experimenter can operate the PDX model through gloves operation mouth 104, guarantee that the PDX model does not receive external environment influence, the reliability of experiment has been guaranteed, the stable existence of PDX model has been ensured, make things convenient for the experimenter to operate simultaneously.
In order to ensure the stable operation of the experiment, a central centralized controller 105 for controlling the temperature, humidity and air environment inside the operation box 101 and the observation box 102 is installed on the top of the operation box 101, and a glove operation opening 104 for facilitating the operation of experimenters is installed at the round notch of the transparent observation window 103.
The operation box 101 and the observation box 102 are both subjected to aseptic sealing treatment.
For convenient observation, transparent glass convenient for observation is installed at the center of the first sealing cover door 201, and a plurality of auxiliary closers 202 are installed around the outer side of the first sealing cover door 201.
The sealing assembly comprises a second sealing cover door 203 and a top sliding rail 205, the top sliding rail 205 is arranged at the top of the middle section connecting box 107, the second sealing cover door 203 is connected with the top sliding rail 205 through a side sliding rail, an auxiliary handle 206 which is convenient to open and close is installed on one side and an extension pipe 204 which controls the stroke is installed at the bottom of the second sealing cover door 203, the other end of the extension pipe 204 is installed on one side of the middle section connecting box 107 through an installation seat, and the sealing performance and the sterile environment of the device are guaranteed through sliding the second sealing cover door 203.
The conveying mechanism 300 comprises a driving cylinder 301 and a top sliding table 302, wherein the driving cylinder 301 is installed on one side of the observation box 102, and the output end of the driving cylinder is connected with the bottom of the top sliding table 302 through a driving rod 303.
Top slip table 302 bottom is equipped with the spout and installs inside observation box 102 through bottom sprag seat 304, starts to drive actuating cylinder 301, drives actuating cylinder 301 and drives top slip table 302 and move to control box 101, guarantees the stability and the sterile environment of experiment.
In order to conveniently control the equipment, the equipment is also provided with a PLC control system, and the PLC control system controls the telescopic state of the driving cylinder 301; the circuit structure and the control principle of the PLC control system are prior art, and are not described in detail in this application.
The foregoing shows and describes the general principles and broad features of the present invention and advantages thereof. It will be understood by those skilled in the art that the present invention is not limited to the embodiments described above, which are described in the specification and illustrated only to illustrate the principle of the present invention, but that various changes and modifications may be made therein without departing from the spirit and scope of the present invention, which fall within the scope of the utility model as claimed. The scope of the utility model is defined by the appended claims and equivalents thereof.
Claims (7)
1. A storage device for PDX model management is characterized in that: comprises that
The box body (100) comprises an operation box (101), an observation box (102) and a middle section connecting box (107), wherein transparent observation windows (103) are arranged at the centers of the outer walls of the two sides of the operation box (101), a connecting port (106) for connecting other external equipment is fixedly arranged at the top of the operation box (101), the middle section connecting box (107) is arranged between the operation box (101) and the observation box (102), and the connecting position is subjected to sealing treatment;
a closing mechanism (200) comprising a first sealing cover door (201) arranged on the observation box (102) through a hinge and a closing component arranged on the middle section connecting box (107);
and a conveying mechanism (300) which is installed inside the observation box (102) and is used for conveying the PDX model into the operation box (101).
2. The storage device for PDX model management as set forth in claim 1, wherein: the central centralized control ware (105) of the inside humiture of control operation case (101) and observation box (102) and air circumstance are installed to operation box (101) top, glove operation mouth (104) that make things convenient for the experimenter to operate are installed to transparent observation window (103) circular breach department.
3. The storage device for PDX model management as set forth in claim 1, wherein: the operation box (101) and the observation box (102) are both subjected to aseptic sealing treatment.
4. The storage device for PDX model management as set forth in claim 1, wherein: transparent glass convenient to observe is installed to first sealed lid door (201) center department, a plurality of supplementary closers (202) are installed all around in first sealed lid door (201) outside.
5. The storage device for PDX model management as set forth in claim 4, wherein: the sealing assembly comprises a second sealing cover door (203) and a top sliding rail (205), the top sliding rail (205) is arranged at the top of the middle section connecting box (107), the second sealing cover door (203) is connected with the top sliding rail (205) through a side sliding way, an auxiliary handle (206) which is convenient to open and close is installed on one side and an extension pipe (204) of a control stroke is installed at the bottom of the second sealing cover door (203), and the other end of the extension pipe (204) is installed on one side of the middle section connecting box (107) through a mounting seat.
6. The storage device for PDX model management as set forth in claim 1, wherein: conveying mechanism (300) are including driving actuating cylinder (301) and top slip table (302), it installs in observation box (102) one side and the output passes through actuating lever (303) and is connected with top slip table (302) bottom to drive actuating cylinder (301).
7. The storage device for PDX model management as set forth in claim 6, wherein: the bottom of the top sliding table (302) is provided with a sliding groove and is arranged in the observation box (102) through a bottom supporting seat (304).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202122823628.XU CN216333593U (en) | 2021-11-17 | 2021-11-17 | Storage device for PDX model management |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202122823628.XU CN216333593U (en) | 2021-11-17 | 2021-11-17 | Storage device for PDX model management |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN216333593U true CN216333593U (en) | 2022-04-19 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202122823628.XU Active CN216333593U (en) | 2021-11-17 | 2021-11-17 | Storage device for PDX model management |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN216333593U (en) |
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2021
- 2021-11-17 CN CN202122823628.XU patent/CN216333593U/en active Active
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