CN216155825U

CN216155825U - Omnibearing rotating shaking table for bioreactor

Info

Publication number: CN216155825U
Application number: CN202122084729.XU
Authority: CN
Inventors: 王嘉鹏; 邰会波; 吴佳佳; 韩中航; 葛忠玉
Original assignee: Changchun Bode Biotechnology Co ltd
Current assignee: Changchun Bode Biotechnology Co ltd
Priority date: 2021-08-31
Filing date: 2021-08-31
Publication date: 2022-04-01
Anticipated expiration: 2031-08-31

Abstract

The utility model discloses an omnibearing bioreactor rotating table concentrator, and relates to the field of bioreactors. The method comprises the following steps: a tray; the blood bag fixing frame is arranged on the tray and used for fixing a blood bag; and wave the drive base, it sets up to wave the drive base the tray lower surface is used for the drive the tray waves, it includes at least to wave the drive base: assembling a chassis; and the shaking generating part is arranged between the assembly chassis and the tray and is used for shaking the tray by 360 degrees. Set up on the tray that the blood bag mount can be fast and firm fix the blood bag, improve operating efficiency, wave the emergence portion that shakes in the drive base simultaneously so that the tray is 360 and waves, realized all-round shaking, improve stirring mixing efficiency, improve work efficiency.

Description

Omnibearing rotating shaking table for bioreactor

Technical Field

The utility model relates to the technical field of bioreactors, in particular to an omnibearing bioreactor rotating table concentrator.

Background

The bioreactor is a device system for carrying out biochemical reaction in vitro by utilizing the biological function of enzyme or organism (such as microorganism), and is a biological function simulator, such as a fermentation tank, an immobilized enzyme or an immobilized cell reactor, and the like. Has important application in the aspects of wine, medicine production, jam concentration, fruit juice fermentation and organic pollutant degradation.

In the existing reagent workshop, three products, namely an ABO blood type reverse typing kit (human red blood cells), an irregular antibody detection kit (human red blood cells) and an indication red blood cell for detecting platelet antibodies (a solid phase agglutination method) are produced by utilizing a split charging mode of combining a bioreactor and a peristaltic pump. The bioreactor used at present has the problems that the fixation of the blood bag is fixed by using a hanging rope, the operation is complicated, the working efficiency is influenced, meanwhile, the supporting plate of the bioreactor enables red blood cells to be stirred with the protective solution in a left-right shaking mode, the shaking mode is single, the mixing effect is poor, the efficiency is low, and the working efficiency is influenced. To improve this, it is necessary to design an all-directional bioreactor rotating shaker.

SUMMERY OF THE UTILITY MODEL

The present invention provides an omnidirectional rotating shaking table of a bioreactor, which aims to solve the technical problems.

In order to solve the technical problems, the technical scheme of the utility model is as follows:

all-round bioreactor rotates shaking table includes:

a tray;

the blood bag fixing frame is arranged on the tray and used for fixing a blood bag;

and wave the drive base, it sets up to wave the drive base the tray lower surface is used for the drive the tray waves, it includes at least to wave the drive base:

assembling a chassis;

and the shaking generating part is arranged between the assembly chassis and the tray and is used for shaking the tray by 360 degrees.

Preferably, the blood bag holder includes:

the vertical rods are symmetrically arranged on the tray in two groups, and the two groups of vertical rods are identical in structure and are arranged in parallel;

the two ends of the cross rod are respectively provided with a height adjusting and fixing mechanism for connecting the two groups of vertical rods in a one-to-one correspondence manner;

and the blood bag clamping and fixing mechanism is arranged on the cross rod and is used for fixing the blood bag.

Preferably, the height adjustment fixing mechanism includes:

the sleeves are coaxially sleeved on the corresponding vertical rods and can move on the vertical rods, and the side surfaces of the sleeves are fixedly connected with the cross rods;

and the first bolt is screwed in from the side surface of the sleeve and tightly propped against the vertical rod.

Preferably, the blood bag holding and fixing mechanism includes:

the first longitudinal plate is connected to the cross rod;

one end of the horizontal supporting plate is connected to the upper end part of the first longitudinal plate;

the upper end part of the second longitudinal plate is connected with one end, opposite to the first longitudinal plate, of the horizontal support plate, and the second longitudinal plate and the first longitudinal plate are arranged in parallel;

a movable clamp plate disposed between the second longitudinal plate and the first longitudinal plate;

the guide supporting mechanism is arranged between the movable clamping plate and the horizontal supporting plate and used for supporting the movable clamping plate and guiding the movable clamping plate to move towards the first longitudinal plate relatively;

and the second bolt is screwed into the second longitudinal plate and is abutted against the movable clamping plate.

Preferably, the guide support mechanism includes:

the bar-shaped guide openings are formed in the horizontal support plate, the extending direction of the bar-shaped guide openings is perpendicular to the first longitudinal plate, and the bar-shaped guide openings are two groups which are arranged in parallel;

the movable support rods are arranged in two groups which are parallel to each other and are in one-to-one correspondence with the two groups of strip-shaped guide openings, one end of each movable support rod is connected to the movable clamping plate, and the other end of each movable support rod penetrates through the corresponding strip-shaped guide opening;

and two ends of the limiting supporting block are respectively connected with the two groups of movable supporting rods which extend out of the movable supporting rods above the strip-shaped guide opening.

Preferably, the assembly chassis includes:

the supporting base is a hollow shell.

Preferably, the shaking generation part includes:

the center of the lower surface of the lower chassis is connected with a supporting rotating shaft, the lower end part of the supporting rotating shaft extends into the supporting base, and the supporting rotating shaft is rotatably connected with the supporting base through a bearing;

the rotating motor is arranged in the supporting base and is in transmission connection with the lower chassis through gear transmission;

the annular supporting body is coaxially connected to the upper surface of the lower chassis;

the arc-shaped bulge is arranged on the upper end surface of the annular supporting body;

the upper chassis is connected to the center of the lower surface of the tray, and the upper chassis and the lower chassis are positioned on the same axis;

a cardan shaft connected between the upper chassis and the lower chassis;

the rollers are arranged on the lower surface of the upper chassis in a circular and uniform distribution mode and are of the same structure, the rollers are connected with the upper chassis through compression springs, and the rollers roll on the annular supporting body.

Preferably, the four edge positions of the lower surface of the tray are provided with support springs in a rectangular distribution mode, and the other ends of the support springs are connected to the assembly chassis to prevent the tray and the assembly chassis from rotating relatively.

The utility model has the following beneficial effects:

according to the omnibearing bioreactor rotating shaking table disclosed by the utility model, the blood bag can be quickly and firmly fixed by arranging the blood bag fixing frame on the tray, so that the operation efficiency is improved, and meanwhile, the shaking generating part in the base is shaken to enable the tray to shake 360 degrees, so that omnibearing shaking is realized, the stirring and mixing efficiency is improved, and the working efficiency is improved.

Drawings

The present invention will be described in further detail with reference to the accompanying drawings and specific embodiments.

FIG. 1 is a schematic view of the construction of an omnidirectional bioreactor rotating shaker of the present invention;

FIG. 2 is a front view of a second longitudinal plate of the omni-directional bioreactor rotating shaker of the present invention;

FIG. 3 is a schematic view showing the arrangement of the rollers of the rocking platforms of the all-directional bioreactor of the present invention;

FIG. 4 is a schematic view of the blood bag holder of the omnibearing bioreactor rotating table according to the present invention;

FIG. 5 is a schematic view showing the distribution of the movable support rods of the rocking platforms of the all-directional bioreactor of the present invention.

The reference numerals in the figures denote:

1. a tray; 2. a vertical rod; 3. a cross bar; 4. a sleeve; 5. a first bolt; 6. a first longitudinal plate; 7. a horizontal support plate; 8. a second longitudinal plate; 9. moving the clamping plate; 10. a second bolt; 11. a strip-shaped guide opening; 12. moving the support rod; 13. a limiting supporting block; 14. a support base; 15. a lower chassis; 16. a support shaft; 17. a rotating electric machine; 18. a circular support body; 19. an arc-shaped bulge; 20. an upper chassis; 21. a cardan shaft; 22. a roller; 23. a compression spring; 24. supporting the spring.

Detailed Description

The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.

Referring to FIGS. 1-5, an all-directional bioreactor rotating shaker includes:

a tray 1 for carrying a blood bag;

the blood bag fixing frame is arranged on the tray 1 and used for fixing the blood bag;

and wave the drive base, wave the drive base setting and rock at the tray lower surface for drive tray 1, wave the drive base and include at least:

an assembly chassis which plays a role of supporting the base and also plays a role of supporting the shake generating part and the tray 1;

and a swing generating part provided between the assembly chassis and the tray 1 to swing the tray 1 at 360 degrees.

Specifically, this device sets up the blood bag mount through tray 1 and can be fast and firm fix the blood bag, improves operating efficiency, waves the emergence portion that shakes in the drive base simultaneously so that tray 1 is 360 and waves, has realized all-round shaking, improves stirring mixing efficiency, improves work efficiency.

Further, blood bag mount includes:

the vertical rods 2 are symmetrically arranged on the tray 1, the two groups of vertical rods 2 are identical in structure and are arranged in parallel, and the vertical rods 2 are fastened on the tray 1 through clamps or screws;

the two ends of the cross rod 3 are respectively provided with a height adjusting and fixing mechanism for connecting the cross rod 3 to the two groups of vertical rods 2 in a one-to-one correspondence manner, the cross rod 3 is supported and mounted by the two groups of vertical rods 2 and is more stable, and the supporting height of the cross rod 3 is adjusted through the height adjusting and fixing mechanisms, so that the fixing of blood bags with different specifications can be better adapted;

and a blood bag clamping and fixing mechanism which is arranged on the cross rod 3 and used for fixing the blood bag.

Further, the height adjustment fixing mechanism includes:

the sleeves 4 are coaxially sleeved on the corresponding vertical rods 2 and can move on the vertical rods 2, and the side surfaces of the sleeves 4 are fixedly connected with the cross rods 3;

and a first bolt 5, wherein the first bolt 5 is screwed in from the side surface of the sleeve 4 and is tightly pressed on the vertical rod 2.

Specifically, after the sleeve 4 drives the cross rod 3 to move up and down to a proper height along the vertical rod 2, the cross rod is tightly supported on the vertical rod 2 through the first bolt 5 to be fastened, and then the cross rod 3 is fixed in height. The height of the blood bag clamping and fixing mechanism, namely the height for fixing and supporting the blood bag is adjusted.

Further, blood bag centre gripping fixed establishment includes:

the first vertical plate 6 is connected to the cross rod 3;

one end of the horizontal supporting plate 7 is connected to the upper end part of the first vertical plate 6;

the upper end part of the second longitudinal plate 8 is connected with one end, opposite to the first longitudinal plate 6, of the horizontal support plate 7, and the second longitudinal plate 8 and the first longitudinal plate 6 are arranged in parallel;

a movable clamping plate 9, wherein the movable clamping plate 9 is arranged between the second vertical plate 8 and the first vertical plate 6;

the guide supporting mechanism is arranged between the movable clamping plate 9 and the horizontal supporting plate 7 and used for supporting the movable clamping plate 9 and guiding the movable clamping plate 9 to move relatively towards the first longitudinal plate 6;

and a second bolt 10, wherein the second bolt 10 is screwed into the second vertical plate 8 and is pressed against the movable clamping plate 9.

Specifically, the second bolt 10 is rotated to engage with the second longitudinal plate 8 by a screw thread, so that the movable clamp plate 9 is pushed against the first longitudinal plate 6, and the movable clamp plate 9 is pushed against the second bolt 10, so that the movable clamp plate 9 engages with the first longitudinal plate 6 to clamp the blood bag. The movable clamping plate 9 is guided to move by the guide supporting mechanism in the process.

Further, the guide support mechanism includes:

the strip-shaped guide openings 11 are formed in the horizontal support plate 7, the extending direction of the strip-shaped guide openings 11 is perpendicular to the first longitudinal plate 6, and the strip-shaped guide openings 11 are two groups which are arranged in parallel;

the movable support rods 12 are two groups which are arranged in parallel and are arranged between the two groups of strip-shaped guide openings 11 in a one-to-one correspondence mode, one end of each movable support rod 12 is connected to the movable clamping plate 9, and the other end of each movable support rod 12 penetrates through the strip-shaped guide openings 11;

and the two ends of the limiting supporting block 13 are respectively connected with the two groups of movable supporting rods 12 extending out of the movable supporting rods 12 above the strip-shaped guide opening 11.

Specifically, in the process of moving the movable clamp plate 9, the movable support rod 12 is driven to move in the strip-shaped guide opening 11, and only the movable clamp plate 9 is driven to move along the extending direction of the strip-shaped guide opening 11, so that the guide effect is achieved. The limiting support block 13 plays a limiting role and prevents the movable support rod 12 from separating from the strip-shaped guide opening 11. The movable support rods 12 and the strip-shaped guide openings 11 are two groups corresponding to each other one by one, so that the movable clamping plate 9 can be prevented from rotating in the moving process to influence normal use.

Further, the assembly chassis includes:

a supporting base 14, wherein the supporting base 14 is a hollow shell. The support base 14 serves firstly to support the entire device stably, and is a hollow housing for the purpose of mounting the constituent elements of the device therein.

Further, the shaking generating part includes:

the center of the lower surface of the lower chassis 15 is connected with a supporting rotating shaft 16, the lower end part of the supporting rotating shaft 16 extends into the supporting base 14, and the supporting rotating shaft 16 is rotatably connected with the supporting base 14 through a bearing;

the rotating motor 17 is arranged inside the supporting base 14, and the rotating motor 17 is in transmission connection with the lower chassis 15 through gear transmission;

the annular supporting body 18, the annular supporting body 18 is coaxially connected to the upper surface of the lower chassis 15;

the arc-shaped bulge 19 is arranged on the upper end surface of the circular ring-shaped support body 18;

the upper chassis 20, the upper chassis 20 is connected to the centre position of the lower surface of the tray 1, the upper chassis 20 and the lower chassis 15 are positioned on the same axle center;

a universal shaft 21, wherein the universal shaft 21 is connected between the upper chassis 20 and the lower chassis 15;

the rollers 22 are multiple groups of rollers with the same structure and are circularly and uniformly distributed on the lower surface of the upper chassis 20, the rollers 22 are connected with the upper chassis 20 through compression springs 23, and the multiple groups of rollers 22 roll on the annular supporting body 18.

Specifically, under the transmission connection of the gear transmission, the rotating motor 17 drives the supporting rotating shaft 16 to rotate, and then drives the lower chassis 15 to rotate, and then drives the circular ring-shaped supporting body 18 and the arc-shaped protrusion 19 to rotate, at this time, the rollers 22 which are installed on the upper chassis 20 and are uniformly distributed in a circular shape roll along the upper edge of the circular ring-shaped supporting body 18, that is, the circular upper edge of the circular ring-shaped supporting body 18 is equivalent to the track of the rollers 22, so that the rollers 22 which are uniformly distributed in a circular shape roll along the upper edge of the circular ring-shaped supporting body 18, and when the arc-shaped protrusion 19 is driven to rotate below each roller 22 in the rotation process of the circular ring-shaped supporting body 18, the gyro wheel 22 rolls all can upwards push up and move tray 1 on arc arch 19, then just also will be in proper order when arc arch 19 rotates the round through the omnidirectional upwards push up of gyro wheel 22 and move tray 1, then drive the omnidirectional of tray 1 and wave. The connection between the roller 22 and the upper chassis 20 is through a compression spring 23, so that when the compression spring 23 is pushed to deflect, the deformation of the compression spring 23 is used to compensate the distance change between different directions between the circular ring support 18 and the upper chassis 20. Meanwhile, the vibration generated when the arc-shaped protrusion 19 passes through the roller 22 can be generated, so that the tray 1 can shake in all directions more stably. In this process, the cardan shaft 21 plays a role of supporting the tray 1, and can simultaneously swing 360 degrees along with the tray.

Further, four marginal positions of tray 1 lower surface are rectangular distribution and are provided with supporting spring 24, and the supporting spring 24 other end is connected on the assembly chassis in order to prevent relative rotation between tray 1 and the assembly chassis, also plays the connection effect between tray 1 and the assembly chassis simultaneously to the supporting role to tray 1.

It should be understood that the above examples are only for clarity of illustration and are not intended to limit the embodiments. Other variations and modifications will be apparent to persons skilled in the art in light of the above description. And are neither required nor exhaustive of all embodiments. And obvious variations or modifications therefrom are within the scope of the utility model.

Claims

1. All-round bioreactor rotates shaking table, its characterized in that includes:

a tray (1);

the blood bag fixing frame is arranged on the tray (1) and used for fixing a blood bag;

and shake the drive base, it sets up to shake the drive base the tray lower surface is used for the drive tray (1) shakes, it includes at least to shake the drive base:

assembling a chassis;

and a shaking generation part which is arranged between the assembly chassis and the tray (1) and is used for shaking the tray (1) in 360 degrees.

2. The omni-directional bioreactor rotating shaker of claim 1, wherein the blood bag holder comprises:

the vertical rods (2) are symmetrically arranged on the tray (1), and the two groups of vertical rods (2) are identical in structure and are arranged in parallel;

the two ends of the cross rod (3) are respectively provided with a height adjusting and fixing mechanism for connecting the two groups of vertical rods (2) in a one-to-one correspondence manner;

and the blood bag clamping and fixing mechanism is arranged on the cross rod (3) and is used for fixing the blood bag.

3. The omni-directional bioreactor rotating shaker of claim 2, wherein the height adjustment fixture comprises:

the sleeves (4) are coaxially sleeved on the corresponding vertical rods (2) and can move on the vertical rods (2), and the side surfaces of the sleeves (4) are fixedly connected with the cross rods (3);

and the first bolt (5), the first bolt (5) is screwed from the side surface of the sleeve (4) and is tightly pressed on the vertical rod (2).

4. The omni-directional bioreactor rotating shaker of claim 2, wherein the blood bag holding fixture comprises:

a first longitudinal plate (6), wherein the first longitudinal plate (6) is connected to the cross bar (3);

one end of the horizontal supporting plate (7) is connected to the upper end part of the first longitudinal plate (6);

the upper end part of the second longitudinal plate (8) is connected with one end, opposite to the first longitudinal plate (6), of the horizontal support plate (7), and the second longitudinal plate (8) and the first longitudinal plate (6) are arranged in parallel;

a mobile clamping plate (9), the mobile clamping plate (9) being arranged between the second longitudinal plate (8) and the first longitudinal plate (6);

the guide supporting mechanism is arranged between the movable clamping plate (9) and the horizontal supporting plate (7) and used for supporting the movable clamping plate (9) and guiding the movable clamping plate (9) to move towards the first longitudinal plate (6) relatively;

and the second bolt (10), the said second bolt (10) is screwed into the said second vertical plate (8) and supported on the said movable clamp plate (9).

5. The omni-directional bioreactor rotating shaker of claim 4, wherein the guide support mechanism comprises:

the bar-shaped guide openings (11) are formed in the horizontal support plate (7), the extending direction of the bar-shaped guide openings (11) is perpendicular to the first longitudinal plate (6), and the bar-shaped guide openings (11) are two groups which are arranged in parallel;

the movable support rods (12) are arranged in two groups which are parallel to each other and are in one-to-one correspondence with the two groups of strip-shaped guide openings (11), one end of each movable support rod (12) is connected to the movable clamping plate (9), and the other end of each movable support rod (12) penetrates through the corresponding strip-shaped guide opening (11);

and the two ends of the limiting supporting block (13) are respectively connected with the two groups of movable supporting rods (12) extending out of the movable supporting rods (12) above the strip-shaped guide opening (11).

6. The omni-directional bioreactor rotating shaker of claim 1, wherein the mounting tray comprises:

the support base (14), support base (14) are hollow casing.

7. The omni-directional bioreactor rotating shaker of claim 6, wherein the shaking generating part comprises:

the center of the lower surface of the lower chassis (15) is connected with a supporting rotating shaft (16), the lower end part of the supporting rotating shaft (16) extends into the supporting base (14), and the supporting rotating shaft (16) is rotatably connected with the supporting base (14) through a bearing;

the rotating motor (17), the said rotating motor (17) is set up in the said support base (14), the said rotating motor (17) and the said lower chassis (15) are connected through the transmission of the gear;

the annular supporting body (18), the said annular supporting body (18) is connected to the upper surface of the said lower chassis (15) coaxially;

the arc-shaped bulge (19) is arranged on the upper end surface of the circular ring-shaped support body (18);

the upper chassis (20), the upper chassis (20) is connected to the central position of the lower surface of the tray (1), and the upper chassis (20) and the lower chassis (15) are positioned on the same axis;

a cardan shaft (21), said cardan shaft (21) being connected between said upper chassis (20) and said lower chassis (15);

the rollers (22) are arranged on the lower surface of the upper chassis (20) in a plurality of groups with the same structure and are distributed in a circular shape, the rollers (22) are connected with the upper chassis (20) through compression springs (23), and the rollers (22) roll on the annular supporting body (18).

8. The all-directional bioreactor rotating shaker as claimed in any one of claims 1-7, wherein the tray (1) is provided with support springs (24) at four edge positions of the lower surface thereof in a rectangular shape, and the other ends of the support springs (24) are connected to the mounting base to prevent the relative rotation between the tray (1) and the mounting base.