CN216082771U

CN216082771U - Antigen-antibody accelerated reaction box

Info

Publication number: CN216082771U
Application number: CN202120981106.XU
Authority: CN
Inventors: 肖腾飞
Original assignee: Shanghai Xunbaihui Biotechnology Co ltd
Current assignee: Shanghai Xunbaihui Biotechnology Co ltd
Priority date: 2021-05-10
Filing date: 2021-05-10
Publication date: 2022-03-18
Anticipated expiration: 2031-05-10

Abstract

The utility model relates to the technical field of biology, in particular to an antigen-antibody accelerated reaction box which comprises a base, wherein a first step groove and a second step groove are respectively formed in two sides of the base, the cross sections of the first step groove and the second step groove are identical in size and shape, a first mounting plate and a second mounting plate are respectively detachably mounted in the first step groove and the second step groove, a plurality of test tube mounting holes identical in size are uniformly formed in the first mounting plate at intervals, a plurality of reagent bottle mounting holes are formed in the second mounting plate, a heating mechanism is arranged at the bottom of the first step groove of the base, a temperature sensor is further arranged in the first step groove, a controller is arranged in the base, and the heating mechanism and the temperature sensor are electrically connected with the controller. The antigen-antibody accelerated reaction box can effectively accelerate the combination of antigen and antibody so as to improve the detection efficiency.

Description

Antigen-antibody accelerated reaction box

Technical Field

The utility model relates to the technical field of biotechnology, in particular to an antigen-antibody accelerated reaction box.

Background

An antigen-antibody reaction refers to a specific binding reaction that occurs between an antigen and a corresponding antibody. This reaction can be carried out either in vivo or in vitro. The important application of specific antibody detection is to assist clinical diagnosis, and also to be an index for observing curative effect and prognosis in some diseases, and the detection of specific antibody has special and important significance in the observation of vaccination effect and epidemiological investigation of infectious diseases.

At present, commonly used antigen-antibody detection kits only carry simple experimental devices such as reagents, multi-well plates and the like, and the antigen and the antibody are fully combined by standing for a certain time in the reaction process of the antigen and the antibody, so that the time consumption is long, and the detection efficiency is low.

SUMMERY OF THE UTILITY MODEL

In order to solve the above-mentioned problems, an object of the present invention is to provide an antigen-antibody accelerated reaction cassette which can effectively accelerate the binding of antigen-antibody to improve the detection efficiency.

In order to achieve the technical effect, the utility model adopts the following technical scheme:

the utility model provides an antigen-antibody accelerated reaction box, includes the base, first ladder groove and second ladder groove have been seted up respectively to the both sides of base, just the big or small shape of cross section in first ladder groove and second ladder groove is the same, first mounting panel and second mounting panel are installed to difference detachably in first ladder groove and the second ladder groove, a plurality of big or small the same test tube mounting holes have been seted up uniformly at the interval on the first mounting panel, a plurality of reagent bottle mounting holes have been seted up on the second mounting panel, the base is provided with heating mechanism in the bottom in first ladder groove, the first ladder inslot still is provided with temperature sensor, be provided with the controller in the base, heating mechanism, temperature sensor all with the controller electricity is connected.

Furthermore, a drawing box is slidably mounted below the second stepped groove on the base, a plurality of test tubes are placed in the drawing box, and the test tubes can be correspondingly mounted in the test tube mounting holes.

Further, heating mechanism is including setting up the heating groove of first step inslot, the heating groove includes bottom plate and curb plate, be provided with the insulating layer between curb plate and the first step groove, the lateral wall and the bottom in first step groove are equipped with first cavity and second cavity respectively, first cavity communicates with each other with the second cavity, just all pack in first cavity and the second cavity and have heating medium, heating mechanism still is including setting up the heating element of bottom plate below.

Further, the heating assembly comprises an electric heating plate which is arranged below the bottom plate and is tightly attached to the bottom plate, a partition plate is arranged below the electric heating plate, a power supply is arranged below the partition plate, and the electric heating plate is electrically connected with the power supply through a wire.

Further, the inner wall of the second stepped groove is provided with a heat insulation layer.

Further, the top end of the first step groove is provided with a first cover plate, the first cover plate is hinged to the base, and the temperature sensor is arranged at the bottom of the first cover plate.

Compared with the prior art, the utility model has the beneficial effects that: the antigen-antibody accelerated reaction box provided by the utility model is provided with the first mounting plate and the second mounting plate which can be alternately mounted in the first ladder groove, when the first mounting plate is heated, an antigen-antibody reaction system in reaction can be heated to accelerate the combination of the first mounting plate and the second mounting plate, and when the second mounting plate is heated, a reagent before participating in the reaction can be preheated, so that the initial temperature of the reaction is further increased, and the combination speed of the antigen and the antibody is increased. In addition, the antigen-antibody accelerated reaction box also eliminates the influence of the ambient temperature on the reaction, and the antigen and the antibody can also be efficiently involved in the reaction when the ambient temperature is low.

Drawings

FIG. 1 is a schematic diagram of an overall structure of an antigen-antibody accelerated reaction cassette according to an embodiment of the present invention;

FIG. 2 is a top view of an antigen-antibody accelerated reaction cassette according to an embodiment of the present invention;

FIG. 3 is a schematic cross-sectional view taken along line A-A of an antigen-antibody accelerated reaction cassette according to an embodiment of the present invention;

the reference signs are: 10, a base, 11, a control panel, 20, a first step groove, 21, a first mounting plate, 211, a magnetic edge strip, 212, a test tube mounting hole, 30, a first cover plate, 31, a temperature sensor, 40, a second step groove, 41, a second mounting plate, 411, a reagent bottle mounting hole, 42, a heat preservation layer, 50, a second cover plate, 60, a drawing box, 70, a heating groove, 701, a first cavity, 702, a second cavity, 71, a heat insulation layer, 72, an electric heating plate, 73, a partition plate, 81, a power supply, 82, a controller, 90 and a positioning metal strip.

Detailed Description

Embodiments of the present invention will be described in detail below with reference to the accompanying drawings. The following examples are only for illustrating the technical solutions of the present invention more clearly, and therefore are only examples, and the protection scope of the present invention is not limited thereby.

As shown in fig. 1-3, the antigen-antibody accelerated reaction cassette provided in this embodiment includes a base 10, wherein a first step groove 20 and a second step groove 40 are respectively formed on two sides of the base 10, and the cross-sectional shapes and the cross-sectional sizes of the first step groove 20 and the second step groove 40 are the same. The first and

second mounting plates

21 and 41 are detachably mounted in the first and second stepped

grooves

20 and 40, respectively, and the mounting positions of the first and

second mounting plates

21 and 41 are exchangeable. A plurality of test tube mounting holes 212 that the size is the same have been seted up evenly at the interval on the first mounting panel 21, test tube mounting hole 212 is used for installing the test tube, a plurality of reagent bottle mounting holes 411 have been seted up on the second mounting panel 41, base 10 is provided with heating mechanism in the bottom of first ladder groove 20, still be provided with temperature sensor 31 in the first ladder groove 20, be provided with controller 82 in the base 10, heating mechanism, temperature sensor 31 all with controller 82 electricity is connected. In specific implementation, the reagent bottles may be correspondingly fixed on the second mounting plate 41, then the second mounting plate 41 is mounted in the first stepped groove 20, and the controller 82 controls the heating mechanism to heat the second mounting plate 41, so as to preheat the reagents in the reagent bottles. After the reagent is preheated, the second mounting plate 41 is placed in the second stepped groove 40, the first mounting plate 21 is correspondingly placed in the first stepped groove 20, and the reagent and the antigen and the antibody to be combined are added into the test tube, so that the temperature of the reaction system is increased and maintained in the process of combining the antigen and the antibody, the combination of the antibody and the antigen is accelerated, and the experimental efficiency is improved.

In this embodiment, a drawing box 60 is slidably installed on the base 10 below the second step groove 40, and a plurality of test tubes are placed in the drawing box 60 and can be correspondingly installed in the test tube installation holes 212. Specifically, the test tube can be used for adding a reagent for combining an antigen and an antibody, and the top of the test tube is provided with a limiting part so as to fix the test tube.

In this embodiment, the heating mechanism includes a heating groove 70 disposed in the first step groove 20, the heating groove 70 includes a bottom plate and a side plate, a heat insulation layer 71 is disposed between the side plate and the first step groove 20, the heat insulation layer 71 is disposed between the side plate and the first step groove 20, a first cavity 701 and a second cavity 702 are respectively disposed on a side wall and a bottom of the first step groove 20, the first cavity 701 and the second cavity 702 are communicated with each other, and heating mediums are filled in the first cavity 701 and the second cavity 702. Specifically, the heating medium is water or oil, so as to improve the uniformity of heating the test tube. Facilitating the binding of antigen to antibody. The heating mechanism further comprises a heating assembly arranged below the bottom plate. Specifically, the heating assembly comprises an electric heating plate 72 which is arranged below the bottom plate and is tightly attached to the bottom plate, a partition plate 73 is arranged below the electric heating plate 72, a power supply 81 is arranged below the partition plate 73, and the electric heating plate 72 is electrically connected with the power supply 81 through a lead. The controller 82 is also disposed below the partition 73, and a control panel 11 is further disposed on the base 10, wherein the control panel 11 is electrically connected to the controller 82. In specific implementation, the controller 82 controls the temperature sensor 31 to detect the temperature in the heating tank 70, and the controller 82 controls the power supply 81 to supply power to the electric heating plate 72, so as to control the temperature in the heating tank 70.

In this embodiment, the inner wall of the second step groove 40 is provided with the insulating layer 42, and the top of the second step groove 40 is further provided with the second cover plate 50 to reduce heat loss.

In this embodiment, the top end of the first stepped groove 20 is provided with a first cover plate 30, the first cover plate 30 is hinged to the base 10, and the temperature sensor 31 is disposed at the bottom of the first cover plate 30, so as to detect the temperature in the first heating groove 70.

In this embodiment, in order to fix the positions of the first mounting plate 21 and the second mounting plate 41, the peripheries of the first mounting plate 21 and the second mounting plate 41 are both provided with a magnetic edge strip 211, and the side walls of the first step groove 20 and the second step groove 40 are both embedded with a positioning metal strip 90 matched with the magnetic edge strip 211 at a step.

Although the present invention has been described in detail with reference to the preferred embodiments, it will be understood by those skilled in the art that various changes may be made and equivalents may be substituted without departing from the spirit and scope of the utility model as defined in the appended claims. The techniques, shapes, and configurations not described in detail in the present invention are all known techniques.

Claims

1. An antigen-antibody accelerated reaction cassette, comprising: including base (10), first step groove (20) and second step groove (40) have been seted up respectively to the both sides of base (10), just the cross section size shape homogeneous phase of first step groove (20) and second step groove (40), first mounting panel (21) and second mounting panel (41) are installed to detachably respectively in first step groove (20) and second step groove (40), a plurality of test tube mounting holes (212) that the size is the same have been seted up uniformly at the interval on first mounting panel (21), a plurality of reagent bottle mounting holes (411) have been seted up on second mounting panel (41), base (10) are provided with heating mechanism in the bottom of first step groove (20), still be provided with temperature sensor (31) in first step groove (20), be provided with controller (82) in base (10), heating mechanism, The temperature sensors (31) are all electrically connected with the controller (82).

2. An antigen-antibody accelerated reaction cassette according to claim 1, wherein: a drawing box (60) is slidably mounted on the base (10) below the second step groove (40), a plurality of test tubes are placed in the drawing box (60), and the test tubes can be correspondingly mounted in the test tube mounting holes (212).

3. An antigen-antibody accelerated reaction cassette according to claim 1, wherein: the heating mechanism comprises a heating groove (70) arranged in the first step groove (20), the heating groove (70) comprises a bottom plate and a side plate, a heat insulation layer (71) is arranged between the side plate and the first step groove (20), a first cavity (701) and a second cavity (702) are respectively arranged on the side wall and the bottom of the first step groove (20), the first cavity (701) is communicated with the second cavity (702), heating media are filled in the first cavity (701) and the second cavity (702), and the heating mechanism further comprises a heating assembly arranged below the bottom plate.

4. An antigen-antibody accelerated reaction cassette according to claim 3, wherein: the heating assembly comprises an electric heating plate (72) which is arranged below the bottom plate and is tightly attached to the bottom plate, a partition plate (73) is arranged below the electric heating plate (72), a power supply (81) is arranged below the partition plate (73), and the electric heating plate (72) is electrically connected with the power supply (81) through a wire.

5. An antigen-antibody accelerated reaction cassette according to claim 1, wherein: and a heat-insulating layer (42) is arranged on the inner wall of the second stepped groove (40).

6. An antigen-antibody accelerated reaction cassette according to claim 1, wherein: the top end of the first step groove (20) is provided with a first cover plate (30), the first cover plate (30) is hinged to the base (10), and the temperature sensor (31) is arranged at the bottom of the first cover plate (30).