CN216024952U

CN216024952U - Micro-fluidic chip for blood detection

Info

Publication number: CN216024952U
Application number: CN202122611858.XU
Authority: CN
Inventors: 王锐; 王坚; 张海娟; 薛蕾
Original assignee: Yunao Biotechnology Changzhou Co ltd
Current assignee: Yunao Biotechnology Changzhou Co ltd
Priority date: 2021-10-28
Filing date: 2021-10-28
Publication date: 2022-03-15
Anticipated expiration: 2031-10-28

Abstract

The utility model discloses a micro-fluidic chip for blood detection, which comprises a base, wherein a threaded rod is vertically and fixedly arranged in the middle of the top end of the base, an installation plate is arranged at the top end of the threaded rod, a plurality of rotating plates are hinged to the outer side of the circumference of the installation plate, and a chip is fixedly arranged on the outer side of each rotating plate; supreme cover in proper order is equipped with regulating block, movable block and spring down in the circumference outside of threaded rod, the circumference outside of movable block is articulated to be provided with a plurality of connecting rods, the connecting rod is kept away from the one end of movable block with the bottom of rotor plate is rotated and is connected. Has the advantages that: through setting up the regulating block, can realize driving the movable block through rotating the regulating block and go up and down to drive the rotor plate through the connecting rod and swing, and then adjust the work angle of multiunit chip, guaranteed the short-term test to hyperlipemia blood.

Description

Micro-fluidic chip for blood detection

Technical Field

The utility model relates to the technical field of sample detection, in particular to a micro-fluidic chip for blood detection.

Background

Microfluidics (Microfluidics) is mainly used for studying the flow performance of some intermediate fluids (i.e. cells, proteins, chromosomes and the like in solution in biological tissues) in a microchannel under the drive of voltage, heat energy and peristaltic pressure difference by using a mode chip as a platform.

The micro-fluidic chip is a main platform for realizing the micro-fluidic technology. The device is characterized in that the effective structure (channels, reaction chambers and other functional components) for containing the fluid is in a micron scale at least in one dimension, the movement of a tiny volume of fluid in a tiny space is controlled, and a chemical or biological laboratory is constructed on a tiny chip, so that various chemical and biological processes are integrated into a rapid and automatic microfluidic system.

In the actual operation process, a blood sample can be detected by adopting a fluorescence micro-fluidic technology, however, most of the existing micro-fluidic chips are fixedly arranged, and for the hyperlipidemia blood with high fat content, the working angle of the fixedly arranged micro-fluidic chip cannot be adjusted according to the viscosity of the hyperlipidemia blood due to high viscosity of the blood, so that blood blockage can be caused, and the detection efficiency of the blood sample is influenced; patent No. CN201910605288.8 discloses a microfluidic chip assembly, which is driven by centrifugal force to achieve the purpose of rapid detection, but the manufacturing cost is high and the carrying is inconvenient and is limited to laboratory use, and the centrifugal force driving can easily cause the sample to splash or adhere to the cover plate, thereby causing the waste of the sample.

An effective solution to the problems in the related art has not been proposed yet.

SUMMERY OF THE UTILITY MODEL

Technical problem to be solved

Aiming at the defects of the prior art, the utility model provides the micro-fluidic chip for blood detection, which has the advantages of simple structure, convenience in carrying and capability of quickly detecting the blood sample with hyperlipidemia, and further solves the problem that the conventional micro-fluidic chip is mostly fixedly arranged and cannot quickly detect the blood sample with hyperlipidemia.

(II) technical scheme

In order to realize the advantages of simple structure, convenient carrying and capability of rapidly detecting the hyperlipemia blood sample, the utility model adopts the following specific technical scheme:

a micro-fluidic chip for blood detection comprises a base, wherein a threaded rod is vertically and fixedly arranged in the middle of the top end of the base, an installation plate is arranged at the top end of the threaded rod, a plurality of rotating plates are hinged to the outer side of the circumference of the installation plate, and a chip is fixedly arranged on the outer side of each rotating plate; supreme cover in proper order is equipped with regulating block, movable block and spring down in the circumference outside of threaded rod, and the circumference outside of movable block is articulated to be provided with a plurality of connecting rods, and the one end that the movable block was kept away from to the connecting rod is rotated with the bottom of rotor plate and is connected.

Furthermore, in order to visually display the rotation angles of the rotating plates and the chip, an angle ruler is vertically arranged at the top end of the mounting plate, and pointers matched with the angle ruler are fixedly arranged at the top ends of a group of rotating plates.

Further, in order to realize detecting the blood sample and accurately controlling the flow rate of the blood sample, the top end of the chip is provided with a sample adding window, a reaction bin, a detection zone, a quality control zone and a waste liquid bin which are sequentially communicated, and the tail end of the reaction bin is clamped and connected with a fluid regulator.

Further, in order to guarantee the stability of chip installation, the top of chip is provided with a plurality of and rotor plate matched with installation cover, and through jackscrew fixed connection between installation cover and the rotor plate, the rotor plate wholly is L shape structure, and the flex point of rotor plate is articulated with the circumference outside of mounting panel.

Furthermore, adjust the regulating block for the convenience to guarantee that the regulating block can rotate from top to bottom in the threaded rod outside, the outline of regulating block is the hexagon structure, and the middle part of regulating block runs through and sets up the internal thread hole with threaded rod matched with.

(III) advantageous effects

Compared with the prior art, the utility model provides the microfluidic chip for blood detection, which has the following beneficial effects:

(1) through setting up the regulating block, can realize driving the movable block through rotating the regulating block and go up and down to drive the rotor plate through the connecting rod and swing, and then adjust the work angle of multiunit chip, guaranteed the short-term test to hyperlipemia blood.

(2) The chip in the utility model uses integrally formed high polymer material, and the plate is uniform and firm and stable in structure, thereby prolonging the service life of the chip; through set up fluid regulator at the end in reaction storehouse, can realize carrying out accurate control to the velocity of flow of blood sample to further accelerate detection speed.

(3) The angle ruler is arranged at the top of the mounting plate, and the pointer matched with the angle ruler is arranged at the top of the rotating plate, so that the rotating angle of the rotating plate and the chip can be visually displayed, the control and the recording are convenient, and the next-time use adjustment is convenient.

Drawings

In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings needed in the embodiments will be briefly described below, and it is obvious that the drawings in the following description are only some embodiments of the present invention, and it is obvious for those skilled in the art to obtain other drawings without creative efforts.

Fig. 1 is an isometric view of a microfluidic chip for blood testing according to an embodiment of the present invention;

FIG. 2 is a schematic diagram of a threaded rod and an adjusting block in a microfluidic chip for blood detection according to an embodiment of the present invention;

FIG. 3 is a schematic diagram of the engagement of a movable block and a rotation plate in a microfluidic chip for blood detection according to an embodiment of the present invention;

FIG. 4 is an enlarged view of a portion of FIG. 3 at A;

fig. 5 is one of schematic structural diagrams of a chip in a microfluidic chip for blood detection according to an embodiment of the present invention;

fig. 6 is a second schematic structural diagram of a microfluidic chip for blood detection according to an embodiment of the present invention.

In the figure:

1. a base; 2. a threaded rod; 3. mounting a plate; 4. a rotating plate; 5. a chip; 501. a sample adding window; 502. a reaction bin; 503. a detection zone; 504. a quality control region; 505. a waste liquid bin; 506. a fluid regulator; 6. an adjusting block; 7. a movable block; 8. a spring; 9. a connecting rod; 10. an angle ruler; 11. a pointer; 12. installing a sleeve; 13. and (5) jacking the screw.

Detailed Description

For further explanation of the various embodiments, the drawings which form a part of the disclosure and which are incorporated in and constitute a part of this specification, illustrate embodiments and, together with the description, serve to explain the principles of operation of the embodiments, and to enable others of ordinary skill in the art to understand the various embodiments and advantages of the utility model, and, by reference to these figures, reference is made to the accompanying drawings, which are not to scale and wherein like reference numerals generally refer to like elements.

According to an embodiment of the present invention, there is provided a microfluidic chip for blood detection.

Referring to the drawings and the detailed description, as shown in fig. 1-6, the microfluidic chip for blood detection according to the embodiment of the present invention includes a base 1, a threaded rod 2 is vertically and fixedly disposed in the middle of the top end of the base 1, a mounting plate 3 is disposed at the top end of the threaded rod 2, a plurality of rotating plates 4 are hinged to the outer side of the circumference of the mounting plate 3, and a chip 5 (the chip 5 is made of an integrally formed polymer material) is fixedly disposed at the outer side of the rotating plates 4; the circumference outside of threaded rod 2 is equipped with regulating block 6, movable block 7 and spring 8 (spring 8 is in compression state) from supreme cover in proper order down, and the circumference outside of movable block 7 articulates and is provided with a plurality of connecting rods 9, and the one end that movable block 7 was kept away from to connecting rod 9 is rotated with the bottom of rotor plate 4 and is connected.

With the aid of above-mentioned technical scheme, through setting up regulating block 6, can realize driving movable block 7 through rotating regulating block 6 and go up and down to drive rotor plate 4 through connecting rod 9 and swing, and then adjust the working angle of multiunit chip 5, guaranteed the short-term test to hyperlipemia blood.

In one embodiment, the top end of the mounting plate 3 is vertically provided with an angle ruler 10, the angle ruler 10 is provided with scale bars and numerical values, and the top end of one group of rotating plates 4 is fixedly provided with a pointer 11 matched with the angle ruler 10, so that the rotating angles of the rotating plates 4 and the chip 5 can be visually displayed, and therefore control and recording are facilitated, and adjustment for next use is facilitated.

In one embodiment, the top end of the chip 5 is provided with a sample application window 501, a reaction chamber 502, a detection chamber 503, a quality control chamber 504 and a waste chamber 505 which are sequentially communicated, and the end of the reaction chamber 502 is clamped with a fluid regulator 506, so that the flow rate of the blood sample can be accurately controlled by the fluid regulator 506.

Specifically, a filtering device is arranged in the sample adding window 501, after a blood sample is added into the sample adding window 501, large particles such as blood cells are intercepted through filtering, blood plasma flows through, the combination of a labeled antibody and target protein is carried out in the reaction bin 502, an S-shaped channel unit is arranged behind the reaction bin and used for controlling fluid so as to achieve the purpose of fully reacting the antibody and the antigen, the traditional combination of the antibody and the target protein adopts the combination principle of protein and membrane, the combination is mainly supported by hypothesis, and the combination depends on practical experience, and the combination of the protein and the plate is very thorough.

In one embodiment, the top end of the chip 5 is provided with a plurality of mounting sleeves 12 matched with the rotating plate 4, the mounting sleeves 12 are fixedly connected with the rotating plate 4 through jackscrews 13, the rotating plate 4 is integrally in an L-shaped structure, and the inflection point of the rotating plate 4 is hinged with the outer side of the circumference of the mounting plate 3, so that the mounting stability of the chip 5 can be ensured.

In one embodiment, the outer contour of the adjusting block 6 is a hexagonal structure, and the middle part of the adjusting block 6 is provided with an internal threaded hole matched with the threaded rod 2 in a penetrating manner, so that the adjusting block 6 can be conveniently adjusted, and the adjusting block 6 can be ensured to rotate up and down on the outer side of the threaded rod 2.

For the convenience of understanding the technical solutions of the present invention, the following detailed description will be made on the working principle or the operation mode of the present invention in the practical process.

In practical application, the working angle of the chip 5 can be adjusted in advance according to the viscosity of a hyperlipemia blood sample to be checked, the adjusting block 6 is rotated, the adjusting block 6 moves on the threaded rod 2 to drive the movable block 7 to move, the movable block 7 drives the connecting rod 9 to rotate, and the other end of the connecting rod 9 drives the rotating plate 4 to rotate around the inflection point of the rotating plate, so that the angle adjustment of the chip 5 is realized; at the moment, the pointer 11 on the inflection point of the rotating plate 4 swings on the surface of the angle ruler 10, so that the working angle of the chip 5 at the moment is displayed, and the angle adjusting precision is guaranteed;

the chip 5 is placed on a workbench by using the base 1, a blood sample to be detected is dripped into the sample adding window 501 on the chip 5, then a cover plate (the cover plate is made of transparent material and covers the chip 5) is covered, the blood sample is accelerated by the fluid regulator 506 after passing through the reaction bin 502, and flows into the position of the detection area 503 in the chip 5 through various flow channels (the inner wall of the flow channel is coated with certain specific substances so as to absorb impurities in liquid to be detected) in the chip 5, so that the content of related components is detected.

In summary, according to the above technical scheme of the present invention, by arranging the adjusting block 6, the adjusting block 6 can be rotated to drive the movable block 7 to ascend and descend, so that the connecting rod 9 drives the rotating plate 4 to swing, and further, the working angles of the plurality of groups of chips 5 are adjusted, thereby ensuring rapid detection of hyperlipidemia blood.

In addition, the chip 5 in the utility model uses integrally formed high molecular material, the board is uniform and the structure is firm and stable, thereby prolonging the service life of the chip; the fluid regulator 506 is arranged at the tail end of the reaction chamber 502, so that the flow rate of the blood sample can be accurately controlled, and the detection speed is further increased; through setting up bevel protractor 10 at the top of mounting panel 3 to set up at the top of rotor plate 4 and bevel protractor 10 matched with pointer 11, can audio-visually demonstrate rotor plate 4 and chip 5's turned angle, thereby convenient control and record, and the regulation of conveniently using next time.

In the present invention, unless otherwise expressly specified or limited, the terms "mounted," "disposed," "connected," "secured," "screwed" and the like are to be construed broadly, e.g., as meaning fixedly connected, detachably connected, or integrally formed; can be mechanically or electrically connected; the terms may be directly connected or indirectly connected through an intermediate, and may be communication between two elements or interaction relationship between two elements, unless otherwise specifically limited, and the specific meaning of the terms in the present invention will be understood by those skilled in the art according to specific situations.

The above description is only for the purpose of illustrating the preferred embodiments of the present invention and is not to be construed as limiting the utility model, and any modifications, equivalents, improvements and the like that fall within the spirit and principle of the present invention are intended to be included therein.

Claims

1. A micro-fluidic chip for blood detection, includes base (1), its characterized in that:

a threaded rod (2) is vertically and fixedly arranged in the middle of the top end of the base (1), a mounting plate (3) is arranged at the top end of the threaded rod (2), a plurality of rotating plates (4) are hinged to the outer side of the circumference of the mounting plate (3), and chips (5) are fixedly arranged on the outer sides of the rotating plates (4);

supreme cover in proper order is equipped with regulating block (6), movable block (7) and spring (8) from down in the circumference outside of threaded rod (2), the circumference outside of movable block (7) is articulated to be provided with a plurality of connecting rods (9), connecting rod (9) are kept away from the one end of movable block (7) with the bottom of rotor plate (4) is rotated and is connected.

2. The microfluidic chip for blood detection according to claim 1, wherein a bevel (10) is vertically arranged at the top end of the mounting plate (3), and a pointer (11) matched with the bevel (10) is fixedly arranged at the top end of one group of the rotating plates (4).

3. The microfluidic chip for blood detection according to claim 1 or 2, wherein a sample application window (501), a reaction chamber (502), a detection chamber (503), a quality control chamber (504) and a waste solution chamber (505) are sequentially communicated with each other at the top end of the chip (5), and a fluid regulator (506) is clamped at the tail end of the reaction chamber (502).

4. The microfluidic chip for blood detection according to claim 1, wherein a plurality of mounting sleeves (12) matched with the rotating plate (4) are arranged at the top end of the chip (5), and the mounting sleeves (12) are fixedly connected with the rotating plate (4) through jackscrews (13).

5. The microfluidic chip for blood detection according to claim 1, wherein the rotating plate (4) is of an L-shaped structure as a whole, and the inflection point of the rotating plate (4) is hinged with the outer side of the circumference of the mounting plate (3).

6. The microfluidic chip for blood detection according to claim 1 or 5, wherein the outer contour of the adjusting block (6) is a hexagonal structure, and an internal threaded hole matched with the threaded rod (2) is formed in the middle of the adjusting block (6) in a penetrating manner.