CN215964161U - Liquid biological sample concentrating device and system for processing liquid biological sample - Google Patents
Liquid biological sample concentrating device and system for processing liquid biological sample Download PDFInfo
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- CN215964161U CN215964161U CN202121225390.4U CN202121225390U CN215964161U CN 215964161 U CN215964161 U CN 215964161U CN 202121225390 U CN202121225390 U CN 202121225390U CN 215964161 U CN215964161 U CN 215964161U
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Abstract
The present invention provides a liquid biological sample concentration device, the device comprising: the centrifugal processing device comprises a fixed part and a rotatable part, wherein the fixed part comprises an upper cover, a rotating seat connected with the upper cover, and a connecting pipe positioned in the upper cover and the rotating seat, the rotatable part comprises a centrifugal processing chamber, and a flow guide piece positioned in the centrifugal processing chamber, and the fixed part and the rotatable part are connected through a plurality of rotary sealing pieces allowing the rotatable part to rotate relative to the fixed part. The present invention also provides a system for processing a liquid biological sample comprising the above liquid biological sample concentrating device.
Description
Technical Field
The present invention relates to a liquid biological sample concentration device, in particular to a device which can be used for continuously concentrating cell samples. The utility model also relates to a system for processing a liquid biological sample comprising the liquid biological sample concentration device described above.
Background
The cell therapy is to separate and extract a part of cells from tissues, peripheral blood and the like of human or animals, and directly return the cells to the human or animals, or return the cells to the human or animals by means of in vitro modification, culture and the like. The cell preparation process in cell therapy will typically involve a cell concentration step. Cell concentration is usually changed from a large culture system to a small preparation system, namely, the culture system is concentrated from hundreds of milliliters to 20 liters to a preparation system of 100-500ml, the concentration volume is usually more than 10 times, and most of clinical-grade cell treatments use closed systems, namely, the cell is completely treated in a closed system from collection to final return transfusion, and the closed system is not in contact with the outside so as to reduce the risks of pollution and cross contamination. Therefore, how to complete the concentration process from a large culture system to a small preparation system in a closed system is an important technical link of the cell preparation process.
The prior art is mainly divided into two types, the first method is completed by a centrifugal system, cell sap is pumped into a barrel through a barrel-shaped centrifugal device, the cell sap is centrifugally separated, waste liquor is discharged, the cell sap is pumped into the barrel again, and the step of centrifugally discharging the waste liquor is repeated until all the cell sap is centrifugally concentrated. The second method is realized by a hollow fiber or membrane filtration method, which generally uses a membrane with uniform pore diameter, and realizes a process of continuously concentrating cells by throttling cells on one side of the membrane and directly discharging waste liquid from the other side of the membrane through pressure by a tangential flow method, wherein the method is characterized in that the liquid pressure and the liquid flow rate are controlled, if the liquid pressure is high and the flow rate is constant, cells are easily blocked by the pressure increase and the cell viability is reduced, and if the liquid pressure is too low, the liquid concentration efficiency is low, so that a long time is needed for concentrating the same volume; the flow rate of increase liquid, then concentration efficiency reduces, produces great frictional force to the cell simultaneously, leads to the cell survival rate to reduce, and the flow rate is too slow, then can lead to the cell deposit, blocks up the surface of membrane, makes the concentration efficiency of membrane reduce gradually, so how to control flow rate and pressure is the key factor of membrane filtration system. Of course, in a membrane filtration system, the total efficiency can also be improved by increasing the surface area of the membrane, but the larger the surface area of the membrane, the higher the cost, and in practical use, the important problem. There is a need in the art for a disposable, cost effective device that can rapidly concentrate cells.
SUMMERY OF THE UTILITY MODEL
The present invention provides the following:
1. a liquid biological sample concentration apparatus, the apparatus comprising:
a fixed portion; and
the rotatable part is provided with a rotatable part,
wherein the fixed part comprises an upper cover, a rotating seat connected with the upper cover, and a connecting pipe positioned in the upper cover and the rotating seat,
wherein the rotatable portion comprises a centrifugal processing chamber, and a flow guide located within the centrifugal processing chamber,
wherein the fixed portion and the rotatable portion are connected by a plurality of rotary seals that allow the rotatable portion to rotate relative to the fixed portion,
wherein the upper cover comprises a first port connected with the inlet and a second port connected with the outlet,
wherein the centrifugal processing chamber comprises an upper wall portion, a neck portion extending upwardly from the upper wall portion, a side wall portion and a downwardly inclined bottom wall portion, wherein the neck portion comprises an upper neck portion and a lower neck portion, wherein a lowest point is formed in the center of the bottom wall portion to enable liquid in the centrifugal processing chamber to be directed towards the lowest point due to gravity,
wherein the baffle is inserted in the centrifugal processing chamber and is rotatable co-axially with the centrifugal processing chamber during centrifugation, wherein the baffle is proximate to but not in contact with the upper wall portion of the centrifugal processing chamber, wherein the baffle is sized and shaped to mate with the upper wall portion of the centrifugal processing chamber, wherein the baffle includes a central bore and the central bore is sized and shaped to mate with the connecting tube, and wherein the connecting tube passes through the central bore,
wherein an upper end of the connection pipe is connected with the outlet, and a lower end of the connection pipe is close to but not in contact with the lowest point, thereby allowing the liquid guided to the lowest point to be discharged from the centrifugal processing chamber, and
wherein the device is configured to receive the liquid sample from the inlet and to sequentially direct the liquid sample to flow through a first space between the upper cap and the connecting tube, a second space between the upper neck and the connecting tube, a third space between the lower neck and the connecting tube, and a fourth space between the upper wall and the baffle and to the sidewall of the centrifugal processing chamber.
2. The apparatus of claim 1, wherein an upper end of the connecting tube is fixed at a second port connected to the outlet.
3. The apparatus of claim 1, further comprising at least one stationary seal.
4. The apparatus of claim 1, further comprising a bearing coupled to both the fixed portion and the rotatable portion.
5. The apparatus of claim 1, wherein the baffle comprises a hollow upwardly projecting central portion connected to the central bore, a plurality of protrusions on a sidewall portion of the upwardly projecting central portion, and wherein the plurality of protrusions are configured to secure the baffle within the neck of the centrifugal processing chamber.
6. The apparatus of claim 5, further comprising an internal dynamic seal disk located within an upper end of the upwardly projecting central portion and connected to a locating sleeve located on an outer wall of the connecting tube by one of the plurality of rotary seals.
7. The apparatus according to claim 1, wherein means for connecting a centrifugal driving apparatus are provided at the bottom of the centrifugal processing chamber.
8. The apparatus of claim 1, wherein the upper wall of the centrifugal processing chamber and the portion of the baffle adjacent the upper wall are horizontal or upwardly inclined.
9. The apparatus of claim 1, wherein the centrifugal processing chamber comprises an upper portion and a lower portion connected to the upper portion, and wherein the upper portion comprises the neck portion, the upper wall portion and the sidewall portion, and the lower portion comprises the downwardly sloped bottom wall portion.
10. The apparatus of claim 1, wherein the first port is connected to the inlet via a first junction and/or the second port is connected to the outlet via a second junction.
11. The apparatus of item 1, wherein the centrifugal processing chamber is rotationally symmetric.
12. A system for processing a liquid biological sample, comprising:
the apparatus of item 1;
at least one sample/wash solution bag;
at least one collection/waste bag; and
a line system for connecting the at least one sample/wash solution bag with the inlet of the apparatus of item 1 and the at least one collection/waste solution bag with the outlet of the apparatus of item 1.
13. The system of claim 12, further comprising a liquid drive device.
14. The system of item 13, wherein the liquid drive device comprises a first peristaltic pump connected to the inlet and/or a second peristaltic pump connected to the outlet.
Drawings
Fig. 1 is a schematic diagram of a system for processing a liquid biological sample including a liquid biological sample concentration device according to one embodiment of the present disclosure.
Fig. 2 is a schematic diagram of a liquid biological sample concentration device according to one embodiment of the present disclosure.
Fig. 3A is a cross-sectional view of the liquid biological sample concentrating device as shown in fig. 2, according to one embodiment of the present disclosure.
Fig. 3B is a cross-sectional view of the liquid biological sample concentrating device as shown in fig. 2 according to another embodiment of the present disclosure.
Fig. 4 is a cross-sectional view of the liquid biological sample concentrating device as shown in fig. 2 according to another embodiment of the present disclosure.
Fig. 5 is a perspective view of a flow guide in the liquid biological sample concentrating device as shown in fig. 2, according to one embodiment of the present disclosure.
Fig. 6 is a side view of the baffle as shown in fig. 5.
Fig. 7 shows a plan view and a cross-sectional view of the baffle as shown in fig. 5.
Fig. 8A is a front side view of an inlet and an outlet in the liquid biological sample concentrating device as shown in fig. 2.
Fig. 8B is a perspective view of an inlet and an outlet in the liquid biological sample concentrating device as shown in fig. 2.
Fig. 9 is a schematic diagram of a system for processing a liquid biological sample including a liquid biological sample concentration device according to another embodiment of the present disclosure.
Detailed Description
Specific embodiments of the present disclosure are described in detail below with reference to the accompanying drawings. It should be understood that the particular embodiments described herein are intended to be illustrative only and are not limiting upon the scope of the utility model.
Fig. 1 is a schematic diagram of a system for processing a liquid biological sample including a liquid biological sample concentration device according to one embodiment of the present disclosure.
Referring to fig. 1, a system 100 for processing a liquid biological sample of the present invention (hereinafter, referred to as the system of the present invention) includes connectors 101 and 102, reservoir bags 104 and 105, line valves 106 and 107, a fluid driving device 108, a connection device 109, and a liquid biological sample processing device 110. In one embodiment, the connectors 101 and 102 may include connectors for connecting to one or more reservoirs. In one embodiment, the adapter 101 connects a reservoir bag with a liquid sample to be processed.
In another embodiment, the adapter 102 is connected to a reservoir bag having a cleaning solution. The reservoirs 104 and 105 may store one or more liquids. In one embodiment, the reservoir bag 104 stores the treated cells. In another embodiment, the reservoir bag 105 stores a separate component to be discarded.
In another embodiment, line valves 106 and 107 may comprise three-way valves. In some embodiments, the fluid drive device 108 may comprise a pump. In one embodiment, the connection device 109 may comprise a peristaltic pump.
Specifically, the liquid biological sample processing device 110 can include at least an inlet and an outlet, a connecting tube, one or more seals, a bearing, a flow guide, and a centrifugal processing chamber.
Fig. 2 is a schematic diagram of a liquid biological sample concentration device according to one embodiment of the present disclosure. In fig. 2, the liquid biological sample processing device 110 includes an inlet 217 and an outlet 216.
Fig. 3A is a cross-sectional view of the liquid biological sample concentrating device as shown in fig. 2, according to one embodiment of the present disclosure. Specifically, fig. 3A shows a cross-sectional view of the liquid biological sample processing device 110. In one embodiment, the liquid biological sample processing device 110 has a fitting 211, a top cover 212, a connecting tube 218, one or more sealing rings 220, one or more rotary seals 219, a rotary seat 221, a bearing 223, a positioning sleeve 224, an internal dynamic seal 226, a centrifugal processing chamber 229, a baffle 228, and a seal 234.
The liquid biological sample processing device 110 includes a stationary portion and a rotatable portion. In one embodiment, the stationary portion may include a coupling tube 218, an upper cover 212, one or more sealing rings 220, a positioning sleeve 224, and a swivel 221. The rotatable portion may include one or more rotary seals 219, an inner dynamic seal 226, a baffle 228 and a centrifugal processing chamber 229.
The upper cover 212 includes an inlet 217 for access to a liquid biological sample to be treated, either directly or through a connector. The upper cover 212 includes an outlet 216 connected directly or through a fitting for discharging the treated liquid. The upper end of the connecting tube 218 is inserted and fixed to the outlet 216 (by an adhesive or interference fit). In one embodiment, the upper cover 212 and the swivel 221 are connected by an interference fit and sealed by one or more sealing rings 220.
The bearing 223 is a bearing connecting the fixed part with the rotatable part. The fixed and rotatable portions are connected by one or more seals, for example by one or more rotary seals 219, such as by resilient engagement, to allow rotation of the rotatable portion relative to the fixed portion.
The inner dynamic seal 226 is disposed within a hollow central protrusion of the centrifugal processing chamber 229. The inner dynamic seal 226 is connected to the locating sleeve 224 by a rotary seal 219. The locating sleeve 224 may be secured to the outer wall of the connecting tube 218 by an adhesive or an interference fit.
The centrifugal processing chamber 229 includes an upper wall portion 227, a neck portion extending upwardly from the upper wall portion 227, a side wall portion 232, and a bottom wall portion 236. In one embodiment, the neck includes an upper neck 250 and a lower neck 252. The lower neck portion 252 is located between the upper neck portion 250 and the upper wall portion 227. In one embodiment, bottom wall portion 236 is a sloped wall that slopes downward. In one embodiment, the centrifugal processing chamber 229 includes an upper portion 240 and a lower portion 242. The upper portion 240 includes a neck portion, an upper wall portion 227 and a side wall portion 232. As shown in fig. 3A, the sidewall portion 232 is part of the upper portion 240. In another embodiment, the sidewall portion 232 can be a portion of the lower portion 242. In one embodiment, the centrifugal processing chamber 229 may be circular or polygonal in cross-section with rotational symmetry.
A portion for connecting a centrifugal driving means is provided at the bottom of the centrifugal processing chamber 229 so that the centrifugal processing chamber 229 can be driven to rotate by the centrifugal driving means. For example, as shown in FIG. 3A, the centrifugal processing chamber 229 has a downward projecting end at the bottom center for connection with a centrifugal drive device.
The flow guide 228 is designed for guiding the liquid sample to, for example, a sidewall portion 232 of the centrifugal process chamber 229. The baffle 228 may be inserted into the centrifugal processing chamber 229 and rotated coaxially with the centrifugal processing chamber 229. The baffle 228 may, for example, comprise an inclined frustoconical upper surface having a hole in the center thereof, the hole being sized and shaped to mate with the connecting tube 218. The frustoconical upper surface is proximate to but not in contact with the upper wall 227. The baffle 228 may include an upwardly projecting central portion. The central portion of the upward projection is hollow and communicates with the central bore of the baffle 228. The connection or fixation of the flow guide 228 and the centrifugal processing chamber 229 may be achieved by using one or more protrusions provided on the outer wall of said upwardly protruding central portion and abutting the inner wall of the lower neck portion 252 of the centrifugal processing chamber 229, for example by a tight fit or an adhesive (see fig. 5-7). In a cross-section taken through gaps between the plurality of projections on the upwardly projecting central portion (fig. 3A), a small space is shown between the central portion of the baffle 238 and the lower neck 252 (see fig. 5-7).
The upper end of the connection pipe 218 is connected to the outlet 216. The lower end of the connecting tube 218 is as close as possible to, but not in contact with, the lowest point 270, thereby allowing liquid collected at the lowest point 270 to be drained from the centrifugal processing chamber 229.
The first liquid passage 260 is defined by a space between the upper cover 212 and the connection pipe 218. The second fluid passage 262 is defined by the space between the upper neck 250 and the connecting tube 218. The third liquid passage 264 is defined by the space between the lower neck 252 and the connecting tube 218. The fourth liquid passage 266 is defined by the space between the upper wall 227 and the baffle 228. The liquid biological sample flows from the inlet 217 and passes through the first liquid channel 260, the second liquid channel 262, the third liquid channel 264 and the fourth liquid channel 266 in this order. The baffle 228 is proximate to but not in contact with the sidewall portion 232. The flow guide 228 guides the liquid passing through the first liquid passage 260, the second liquid passage 262, the third liquid passage 264 and the fourth liquid passage 266 to the side wall portion 232.
Fig. 3B is a cross-sectional view of the liquid biological sample concentrating device as shown in fig. 2 according to another embodiment of the present disclosure.
As described above, the baffle 228 is attached to the lower neck 252 of the centrifugal processing chamber 229 using a protrusion (e.g., by a tight fit) or an adhesive. In a cross-sectional view (fig. 3B) taken through the lobes on the upwardly projecting central portion of the baffle 228 (rather than the gaps between the lobes), there is no space between the upwardly projecting central portion of the baffle 228 and the lower neck 252 (see fig. 5-7).
The liquid sample containing the cells is directed by the flow guide 228 to the sidewall portion 232 of the spinning centrifugal processing chamber 229. In one embodiment, the centrifugal force at the sidewall of centrifugal processing chamber 229 is much greater than the centrifugal force at the center of centrifugal processing chamber 229. After exposure to horizontal sedimentation forces, the cells are separated from the supernatant or other medium. The cells settle on the inner wall of the centrifugal processing chamber 229 including the sidewall portion 232, and the separated waste liquid is discharged through the connecting tube 218 and the outlet 216 at the center of the centrifugal processing chamber 229.
In one embodiment, the liquid biological sample processing device 110 is designed for continuous introduction of a liquid sample containing cells and continuous discharge of waste. The cells settle on the inner wall of the centrifugal processing chamber 229, thereby achieving the purpose of cell concentration.
In contrast to the flow guide 228 being configured to guide the liquid sample to the sidewall portion 232 of the centrifugal processing chamber 229, if the liquid sample flows into the centrifugal processing chamber 229 from the central axis of the liquid biological sample processing device 110, it will take longer for the cells in the liquid sample to be distributed to the sidewall portion 232 of the centrifugal processing chamber 229 under the influence of centrifugal force. In this case, if the inflow speed of the liquid sample is increased, the cells in the liquid sample will not have enough time to reach the inner wall of the centrifugal processing chamber 229 and may be discharged out of the centrifugal processing chamber 229, resulting in a low cell yield. In the present disclosure, the liquid sample containing the cells directly reaches the sidewall portion 232 of the centrifugal processing chamber 229, so that the cells can be easily distributed to the sidewall portion 232 of the centrifugal processing chamber 229 under the centrifugal force. Thus, in the present disclosure, the centrifugation duration can be reduced and high cell yields can be achieved at high flow rates.
Fig. 4 is a cross-sectional view of the liquid biological sample concentrating device as shown in fig. 2 according to another embodiment of the present disclosure.
In fig. 4, the inlet 217, outlet 216 and connecting tube 218 are as described for fig. 3A. The space 313 is a space between the upper cover 212 and the connection pipe 218. The space 314 is the space between the upper neck 250 and the connecting tube 218. The space 318 is the space between the lower neck 252 and the connecting tube 218. The space 317 is a space between the upper wall portion 227 and the baffle 228. Referring to fig. 3A, 3B and 4, a liquid sample containing cells passes through inlet 217, space 313, space 314, space 318 and space 317 in that order, and is finally received by centrifugal processing chamber 229.
Fig. 5 is a perspective view of a flow guide in the liquid biological sample concentrating device as shown in fig. 2, according to one embodiment of the present disclosure. Fig. 6 is a side view of the baffle as shown in fig. 5. Fig. 7 shows a plan view and a cross-sectional view of the baffle as shown in fig. 5.
Referring to fig. 5-7, the baffle 228 has an inclined frustoconical upper surface 460 (the baffle 228 may also have a horizontal configuration in addition to the inclined configuration shown in the figures), a central portion 238, and six protrusions 400, 410, 420, 430, 440, and 450 disposed on the central portion 238. The number of projections on the baffle 228 may not be limited to six and may be one, two, three, four, five, or any number. The protrusions may have any shape, including stripes, cubes, dots, rings, and the like. The protrusion may extend from the central portion 238 to the upper surface 460. In one embodiment, the protrusion (e.g., 410) may comprise a base element (e.g., 401). In one embodiment, a liquid sample containing cells can flow through the spaces 470 between adjacent projections.
Fig. 8A is a front side view of an inlet and an outlet in the liquid biological sample concentrating device as shown in fig. 2.
Fig. 8B is a perspective view of an inlet and an outlet in the liquid biological sample concentrating device as shown in fig. 2.
Fig. 9 is a schematic diagram of a system for processing a liquid biological sample including a liquid biological sample concentration device according to another embodiment of the present disclosure.
Referring to fig. 9, the system for processing a liquid biological sample of the present invention includes connectors 101 and 102 for use with a liquid biological sample processing device 110, reservoir bags 104 and 105, line valves 106 and 107, and a fluid driving device 108. In one embodiment, the connectors 101 and 102 may include connectors for connecting to one or more reservoirs. The reservoirs 104 and 105 may store one or more liquids.
In one embodiment, the adapter 101 is connected to a reservoir containing a liquid sample to be processed. In another embodiment, the connector 102 is connected to a reservoir containing a washing solution. In one embodiment, the reservoir bag 104 stores the final solution containing the target cells. In another embodiment, the reservoir bag 105 stores waste fluid. In another embodiment, line valves 106 and 107 may comprise three-way valves. In some embodiments, the fluid drive device 108 may comprise a pump.
As shown in fig. 9, the system for processing a liquid biological sample of the present invention may further include a pressure sensor 1205 and a gas supply 1207 controlled by a control switch 1209 (default to an off state).
Claims (14)
1. A liquid biological sample concentrating apparatus, characterized in that the apparatus comprises:
a fixed portion; and
the rotatable part is provided with a rotatable part,
wherein the fixed part comprises an upper cover, a rotating seat connected with the upper cover, and a connecting pipe positioned in the upper cover and the rotating seat,
wherein the rotatable portion comprises a centrifugal processing chamber, and a flow guide located within the centrifugal processing chamber,
wherein the fixed portion and the rotatable portion are connected by a plurality of rotary seals that allow the rotatable portion to rotate relative to the fixed portion,
wherein the upper cover comprises a first port connected with the inlet and a second port connected with the outlet,
wherein the centrifugal processing chamber comprises an upper wall portion, a neck portion extending upwardly from the upper wall portion, a side wall portion and a downwardly inclined bottom wall portion, wherein the neck portion comprises an upper neck portion and a lower neck portion, wherein a lowest point is formed in the center of the bottom wall portion to enable liquid in the centrifugal processing chamber to be directed towards the lowest point due to gravity,
wherein the baffle is inserted in the centrifugal processing chamber and is rotatable co-axially with the centrifugal processing chamber during centrifugation, wherein the baffle is proximate to but not in contact with the upper wall portion of the centrifugal processing chamber, wherein the baffle is sized and shaped to mate with the upper wall portion of the centrifugal processing chamber, wherein the baffle includes a central bore and the central bore is sized and shaped to mate with the connecting tube, and wherein the connecting tube passes through the central bore,
wherein an upper end of the connection pipe is connected with the outlet, and a lower end of the connection pipe is close to but not in contact with the lowest point, thereby allowing the liquid guided to the lowest point to be discharged from the centrifugal processing chamber, and
wherein the device is configured to receive the liquid biological sample from the inlet and to sequentially direct the liquid biological sample to flow through a first space between the upper cap and the connecting tube, a second space between the upper neck and the connecting tube, a third space between the lower neck and the connecting tube, and a fourth space between the upper wall and the baffle and to the sidewall of the centrifugal processing chamber.
2. The apparatus of claim 1, wherein an upper end of the connecting tube is fixed at a second port connected to the outlet.
3. The apparatus of claim 1, further comprising at least one stationary seal.
4. The apparatus of claim 1, further comprising a bearing coupled to both the fixed portion and the rotatable portion.
5. The apparatus of claim 1, wherein said baffle member comprises a hollow upwardly projecting central portion connected to said central bore, a plurality of protrusions located on side wall portions of said upwardly projecting central portion, and wherein said plurality of protrusions are configured to secure said baffle member within a neck portion of said centrifugal processing chamber.
6. The apparatus of claim 5, further comprising an internal dynamic seal disk located within the upper end of the upwardly projecting central portion and connected to a locating sleeve located on the outer wall of the connecting tube by one of the plurality of rotary seals.
7. The apparatus of claim 1, wherein means for connecting a centrifugal driving device are provided at the bottom of the centrifugal processing chamber.
8. The apparatus of claim 1 wherein the upper wall portion of the centrifugal processing chamber and the portion of the baffle adjacent the upper wall portion are horizontal or upwardly inclined.
9. The apparatus of claim 1 wherein said centrifugal processing chamber comprises an upper portion and a lower portion connected to said upper portion, and wherein said upper portion comprises said neck portion, said upper wall portion and said sidewall portion, and said lower portion comprises said downwardly sloping bottom wall portion.
10. The apparatus of claim 1, wherein the first port is connected to the inlet via a first connector and/or the second port is connected to the outlet via a second connector.
11. The apparatus of claim 1, wherein said centrifugal processing chamber is rotationally symmetric.
12. A system for processing a liquid biological sample, comprising:
the liquid biological sample concentration device of claim 1;
at least one sample/wash solution bag;
at least one collection/waste bag; and
a line system for connecting the at least one sample/wash solution bag with the inlet of the liquid biological sample concentration device of claim 1 and the at least one collection/waste solution bag with the outlet of the liquid biological sample concentration device of claim 1.
13. The system of claim 12, further comprising a fluid-driven device.
14. The system of claim 13, wherein the fluid driving device comprises a first peristaltic pump connected to the inlet and/or a second peristaltic pump connected to the outlet.
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| Application Number | Priority Date | Filing Date | Title |
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| CN202121225390.4U CN215964161U (en) | 2021-06-02 | 2021-06-02 | Liquid biological sample concentrating device and system for processing liquid biological sample |
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| CN202121225390.4U CN215964161U (en) | 2021-06-02 | 2021-06-02 | Liquid biological sample concentrating device and system for processing liquid biological sample |
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