CN215822406U - Flow dividing and purifying flow path control system - Google Patents

Abstract

The utility model relates to the technical field of pipelines, in particular to a flow dividing and purifying flow path control system which comprises a main path, a plurality of branch paths and a plurality of branch paths, wherein the main path is suitable for conveying a solvent to the branch paths through a solvent pump; each branch comprises a mass flow meter and a flow regulating valve, two adjacent branches are converged in a bypass, and the bypass is communicated with the confluence box; wherein the mass flow meter is adapted to detect a flow rate of solvent on the respective branch; the flow regulating valves are suitable for regulating the proportion of the solvent on the corresponding branch. The utility model takes a high-precision system pressure stabilizing valve and a micro-fluidic flow dividing technology as the core, develops a multi-flow-path parallel transfusion system, realizes the parallel separation and elution of a plurality of chromatographic columns under the same gradient condition through a mass flow meter and a flow regulating valve bank, and can also respectively elute simultaneously according to different elution conditions corresponding to each column.

Description

Flow dividing and purifying flow path control system

Technical Field

The utility model relates to the technical field of pipelines, in particular to a flow dividing and purifying flow path control system.

Background

The systematic separation and purification preparation of one traditional Chinese medicine prescription/decoction piece (hundred kg grade) can be completed according to 3 days, the requirement of more than 300 compounds for purification preparation is obtained, and a multi-channel system in the multi-dimensional multi-channel purification and separation device needs 10-60 chromatographic columns to work simultaneously. The gradient, isocratic and flow control of an elution solvent in the traditional preparation process of the preparative liquid chromatography mainly comprises a high-pressure gradient and a low-pressure gradient, wherein the high-pressure gradient is realized by matching the flow of two or more high-pressure constant-flow mobile phase pumps, the mobile phase elution with different concentrations and gradients is realized by mixing after the pumps, the low-pressure gradient is realized by additionally arranging a proportional valve in front of the pumps, and the mixing of different mobile phase solvents is realized in front of the pumps through the proportional valve, so that the elution can only correspond to the single-column elution. According to the conventional mode, 10-60 sets of independent preparative chromatographic systems need to be configured, and the problems of high cost, synchronism, repeatability and the like exist, so that the feasibility is low.

SUMMERY OF THE UTILITY MODEL

The utility model provides a flow dividing and purifying flow path control system for solving the problem that a specification cannot be well placed in a medicine box, which comprises,

a main circuit adapted to deliver solvent to the plurality of branches via a solvent pump; each branch comprises a mass flow meter and a flow regulating valve, two adjacent branches are converged in a bypass, and the bypass is communicated with the confluence box; wherein the content of the first and second substances,

the mass flow meter is suitable for detecting the flow rate of the solvent on the corresponding branch;

the flow regulating valves are suitable for regulating the proportion of the solvent on the corresponding branch.

Further, the main road comprises a first main road, a second main road, a third main road and a fourth main road, the first main road, the second main road, the third main road and the fourth main road are all communicated with each branch through four-way valves, wherein,

and the first main road, the second main road, the third main road and the fourth main road are all provided with overflow pressure stabilizing valves.

Furthermore, the first main road, the second main road, the third main road and the fourth main road are all provided with sample injection pumps.

Further, pressure sensors are further arranged on the first main road, the second main road, the third main road and the fourth main road.

Furthermore, a pressure stabilizing valve is communicated with the bypass and is suitable for ensuring the pressure on the bypass to be stable.

Furthermore, the mass flow meter and the flow regulating valve are in signal connection with a control system.

Further, a pressure sensor is arranged on the bypass, and the pressure sensor is suitable for monitoring the pressure on the bypass.

Furthermore, a first three-way valve and a second three-way valve are further arranged on the bypass, the first three-way valve is communicated with the waste bin and the second three-way valve, and the second three-way valve is communicated with the feeding pump and the confluence box; wherein the content of the first and second substances,

the feeding pump is suitable for conveying a sample into the second three-way valve to be mixed with the bypass solvent;

the waste bin is suitable for recycling unqualified solvent.

Has the advantages that: the utility model takes a high-precision system pressure stabilizing valve and a micro-fluidic flow dividing technology as the core, develops a multi-flow-path parallel transfusion system, realizes the parallel separation and elution of a plurality of chromatographic columns under the same gradient condition through a mass flow meter and a flow regulating valve bank, and can also respectively elute simultaneously according to different elution conditions corresponding to each column.

Drawings

FIG. 1 is a schematic view of the overall structure of the present invention;

in the figure:

100. a main road; 110. a first main road, 120, a second main road, 130, a third main road, 140 and a fourth main road; 150. an overflow pressure stabilizing valve 160 and a pressure sensor; 170. a sample injection pump; 180. a combiner box;

200. a branch circuit; 210. a mass flow meter; 220. a flow regulating valve; 230. a four-way valve;

300. a bypass; 310. pressure stabilizing valve 320, waste box 330, three-way valve I, 340, feeding pump 350, sample 360 and three-way valve II.

Detailed Description

In order to make the technical solutions of the present invention better understood, the technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.

Reference herein to "one embodiment" or "an embodiment" means that a particular feature, structure, or characteristic may be included in at least one implementation of the utility model. In the description of the present invention, it is to be understood that the terms "upper", "top", "bottom", and the like, as used herein, refer to an orientation or positional relationship based on that shown in the drawings, which is for convenience in describing the present invention and simplifying the description, and do not indicate or imply that the device or element referred to must have a particular orientation, be constructed in a particular orientation, and be operated, and thus, should not be taken as limiting the present invention. Furthermore, the terms "first", "second" and "first" are used for descriptive purposes only and are not to be construed as indicating or implying relative importance or implicitly indicating the number of technical features indicated. Thus, a feature defined as "first" or "second" may explicitly or implicitly include one or more of that feature. Moreover, the terms "first," "second," and the like are used for distinguishing between similar elements and not necessarily for describing a particular sequential or chronological order. It is to be understood that the data so used is interchangeable under appropriate circumstances such that the embodiments of the utility model described herein are capable of operation in sequences other than those illustrated or described herein.

Example 1

As shown in fig. 1, a split purification flow path control system includes,

a main circuit 100, said main circuit 100 being adapted to convey solvent to a plurality of branch circuits 200 by means of a solvent pump; each branch 200 comprises a mass flow meter 210 and a flow regulating valve 220, two adjacent branches 200 are converged into a bypass 300, and the bypass 300 is communicated with the confluence box 180; wherein the content of the first and second substances,

the mass flow meter 210 is adapted to detect the flow of solvent on the respective branch 200;

the flow regulating valve 220 is adapted to regulate the proportion of solvent on the respective branch 200.

Main road 100

The main line 100 may be linear, or may be in any shape such as arc, and the main line 100 is suitable for conveying the solvent to the plurality of branches 200 by the solvent pump.

The main circuit 100 comprises a first main circuit 110, a second main circuit 120, a third main circuit 130 and a fourth main circuit 140, the first main circuit 110, the second main circuit 120, the third main circuit 130 and the fourth main circuit 140 are all communicated with each branch circuit 200 through a four-way valve 230, wherein overflow pressure stabilizing valves 150 are arranged on the first main circuit 110, the second main circuit 120, the third main circuit 130 and the fourth main circuit 140. Relief pressure regulator valve 150 ensures that the pressure on first, second, third and fourth manifolds 110, 120, 130, 140 is stable.

In order to allow the solvent to enter the first, second, third and fourth manifolds 110, 120, 130 and 140, sample pumps 170 are respectively disposed on the first, second, third and fourth manifolds 110, 120, 130 and 140.

In order to monitor the pressure on the first, second, third and fourth main lines 110, 120, 130 and 140, pressure sensors 160 are further disposed on the first, second, third and fourth main lines 110, 120, 130 and 140.

Branch 200

The branch circuits 200 are communicated with the main circuit 100, each branch circuit 200 comprises a mass flow meter 210 and a flow regulating valve 220, and the mass flow meter 210 is suitable for detecting the flow of the solvent on the corresponding branch circuit 200; the flow regulating valve 220 is adapted to regulate the proportion of solvent on the respective branch 200. The mass flow meter 210 and the flow regulating valve 220 are in signal connection with a control system. The mass flow meter 210 and the flow regulating valve 220 realize the accurate control of different solvents, the mass flow meter 210 and the flow regulating valve 220 form a single loop, and the mass flow meter 210 feeds back to the control system while detecting the solvent flow on the branch 200.

Bypass 300

The bypass 300 is formed by converging two branches 200, and the bypass 300 is communicated with the confluence box 180.

A pressure maintaining valve 310 is communicated with the bypass 300, and the pressure maintaining valve 310 is suitable for ensuring the pressure on the bypass 300 to be stable. A pressure sensor 160 is provided on the bypass 300, the pressure sensor 160 being adapted to monitor the pressure on the bypass 300. The bypass 300 is further provided with a first three-way valve 330 and a second three-way valve 360, the first three-way valve 330 is communicated with the waste tank 320 and the second three-way valve 360, and the second three-way valve 360 is communicated with the feed pump 340 and the confluence tank 180; wherein the feed pump 340 is adapted to deliver the sample 350 into the second three-way valve 360 to mix with the bypass 300 solvent; the waste bin 320 is adapted to recover off-spec solvent. The bypass 300 is provided with a first three-way valve 330 and a second three-way valve 360, one valve port of the first three-way valve 330 is communicated with the two branches 200 communicated with the bypass 300, the other two branches are respectively communicated with the second three-way valve 360 and the waste box 320, one valve port of the second three-way valve 360 is communicated with the first three-way valve 330, the other two valve ports are respectively communicated with the feed pump 340 and the confluence box 180, and the feed pump 340 conveys the sample 350 to the solvent in the second three-way valve 360 for mixing. The waste tank 320 recovers the unqualified solvent detected by the mass flow meter 210 and the flow regulating valve 220.

The working principle is as follows: the solvent is input to the first main line 110, the second main line 120, the third main line 130 and the fourth main line 140 by the sample pump 170, and the solvent is input to the two adjacent branches 200 by the first main line 110, the second main line 120, the third main line 130 and the fourth main line 140. The mass flowmeters 210 on the two branches 200 detect the flow of the solvent on the corresponding branch 200, the flow regulating valves 220 regulate the proportion of the solvent on the corresponding branch 200, the mass flowmeters 210 and the flow regulating valves 220 feed back information to the control system, and the liquid in the two branches 200 is then converged on the bypass 300. When off-specification solvent is present, the solvent flows to the first three-way valve 330, from the first three-way valve 330 of the bypass 300 to the waste tank 320. When the solvent is qualified, the qualified solvent flows into the second three-way valve 360, and the feed pump 340 conveys the sample 350 into the second three-way valve 360, mixes with the qualified solvent of the bypass 300, and then flows into the combiner box 180.

The above description is only for the purpose of illustrating the preferred embodiments of the present invention and is not to be construed as limiting the utility model, and any modifications, equivalents, improvements and the like that fall within the spirit and principle of the present invention are intended to be included therein.

Claims (8)

1. A split stream purification flow path control system, comprising,

a main circuit adapted to deliver solvent to the plurality of branches via a solvent pump; each branch comprises a mass flow meter and a flow regulating valve, two adjacent branches are converged in a bypass, and the bypass is communicated with the confluence box; wherein the content of the first and second substances,

the mass flow meter is suitable for detecting the flow rate of the solvent on the corresponding branch;

the flow regulating valves are suitable for regulating the proportion of the solvent on the corresponding branch.

2. The split-flow purification flow path control system of claim 1,

the main road comprises a first main road, a second main road, a third main road and a fourth main road, the first main road, the second main road, the third main road and the fourth main road are all communicated with each branch through four-way valves, wherein,

and the first main road, the second main road, the third main road and the fourth main road are all provided with overflow pressure stabilizing valves.

3. The split-flow purification flow path control system of claim 2,

and the first main road, the second main road, the third main road and the fourth main road are all provided with sample injection pumps.

4. The split-flow purification flow path control system of claim 3,

and pressure sensors are further arranged on the first main road, the second main road, the third main road and the fourth main road.

5. The split-flow purification flow path control system of claim 1,

and the bypass is communicated with a pressure stabilizing valve, and the pressure stabilizing valve is suitable for ensuring the pressure stability on the bypass.

6. The split-flow purification flow path control system of claim 5,

and the mass flow meter and the flow regulating valve are in signal connection with the control system.

7. The split-flow purification flow path control system of claim 1,

a pressure sensor is disposed on the bypass, the pressure sensor adapted to monitor a pressure on the bypass.

8. The split-flow purification flow path control system of claim 1,

a first three-way valve and a second three-way valve are further arranged on the bypass, the first three-way valve is communicated with the waste bin and the second three-way valve, and the second three-way valve is communicated with the feeding pump and the confluence box; wherein the content of the first and second substances,

the feeding pump is suitable for conveying a sample into the second three-way valve to be mixed with the bypass solvent;

the waste bin is suitable for recycling unqualified solvent.

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