CN215811992U - Sample mixing and sample adding device for Raman spectrum detection - Google Patents

Abstract

The utility model discloses a sample mixing and loading device for Raman spectrum detection. Foretell sample mixing application of sample device for raman spectroscopy detects includes mixing subassembly, extrusion subassembly and vibrations drive assembly, the mixing subassembly includes mixing vibrations piece and mixing pole, one of them end connection of mixing pole has mixing vibrations piece, another tip of mixing pole with the detachable connection of vibrations drive assembly, extrusion subassembly detachable connection in mixing pole and can along mixing pole removes in order to extrude scraping sample liquid on the mixing pole. The sample mixing and sample adding device for Raman spectrum detection can effectively solve the problems that the existing malarial pigment sample is difficult to mix uniformly and the available amount of the malarial pigment sample is reduced after mixing, achieves the purposes of good malarial pigment sample mixing effect and small malarial pigment sample mixing loss amount, and realizes direct sample loading and convenient sample loading after mixing.

Description

Sample mixing and sample adding device for Raman spectrum detection

Technical Field

The utility model relates to the technical field of biological detection, in particular to a sample mixing and adding device for Raman spectrum detection.

Background

The method for detecting malaria samples by Raman spectroscopy comprises a plurality of detection methods, wherein one method is a method for extracting hemozoin from red blood cells for detection. In the method for extracting the hemozoin from the red blood cells for detection, after the hemozoin is extracted, a hemozoin sample needs to be uniformly mixed with other reagents; because the content of the malaria pigment is less, if the traditional method of blowing, beating and uniformly mixing the malaria pigment sample by a sample adding gun is adopted, the malaria pigment sample is difficult to be well mixed; if the oscillator is adopted for mixing, the malaria pigment sample can be adhered to the tube wall of the centrifuge tube, the available amount of the malaria pigment sample can be further reduced, and the follow-up detection requirements are difficult to meet.

SUMMERY OF THE UTILITY MODEL

Therefore, it is necessary to provide a sample mixing and loading device for raman spectroscopy detection, which aims at the problems that the existing hemozoin sample is difficult to mix uniformly and the available amount of the hemozoin sample is reduced after mixing.

The utility model provides a Raman spectrum detects with sample mixing application of sample device, includes mixing subassembly, extrusion subassembly and vibrations drive assembly, the mixing subassembly includes that the mixing shakes and moves and mixing pole, one of them end connection of mixing pole has the mixing shakes and moves, another tip of mixing pole with the detachable connection of vibrations drive assembly, extrusion subassembly detachable connection in the mixing pole and can along the mixing pole removes in order to extrude scraping sample liquid on the mixing pole.

In one embodiment, the extrusion assembly comprises an extrusion ring and an extrusion handle, the extrusion ring can be sleeved on the blending rod and can slide along the blending rod, and the extrusion handle is connected to the extrusion ring.

In one embodiment, the squeezing handle is provided with a holding part for being held by an operator.

In one embodiment, the outer wall of the extrusion ring is provided with a limiting clamping groove, the extrusion handle is sleeved on the outer wall of the extrusion ring, and the extrusion handle is clamped in the limiting clamping groove.

In one embodiment, the limiting clamping groove is an annular groove which surrounds the outer wall of the extrusion ring for one circle.

In one embodiment, the compression ring is resilient.

In one embodiment, the extrusion ring is of a cylindrical structure, and the outer wall of the extrusion ring is gradually narrowed from one end far away from the blending vibration part to one end close to the blending vibration part.

In one embodiment, the vibratory drive assembly is a peristaltic pump.

In one embodiment, the blending vibration member is a spherical structure or an ellipsoidal structure.

In one embodiment, the mixing rod is in threaded connection with the vibration driving assembly.

The sample mixing and sample adding device for Raman spectrum detection can effectively solve the problems that the existing malarial pigment sample is difficult to mix uniformly and the available amount of the malarial pigment sample is reduced after mixing, achieves the purposes of good malarial pigment sample mixing effect and small malarial pigment sample mixing loss amount, and achieves the effects of direct sample loading and convenient sample loading after mixing. Foretell raman spectrum detects with sample mixing application of sample device has realized the dual purpose of the mixing of malarial pigment sample and application of sample through setting up mixing subassembly, extrusion subassembly and vibrations drive assembly, can directly carry out the application of sample operation after the malarial pigment sample mixing finishes, need not the step of the application of sample rifle imbibition among the traditional approach, has reduced the loss of malarial pigment sample content, the follow-up demand that detects of being convenient for. When the malarial pigment sample needs the mixing, through vibrations drive assembly drive the action of mixing subassembly, the mixing pole vibrations of mixing subassembly are in order to drive the vibrations of mixing vibrations piece, and the vibrations of mixing vibrations piece drive the mixing of the malarial pigment sample in the centrifuge tube. When the malaria pigment sample need the point sample, remove the relation of connection between vibrations drive assembly and the mixing rod, shift the mixing rod to waiting the application of sample position, control extrusion subassembly along the mixing rod removes to realize that extrusion subassembly extrudees the mixing rod of scraping, malaria pigment sample liquid on the mixing rod can move down along the mixing rod, finally carry out the point sample through the mixing vibrations piece of mixing rod tip.

Foretell for raman spectroscopy detect sample mixing application of sample device is through setting up extrusion ring and extrusion handle, has made things convenient for operating personnel's operation, and when the application of sample, operating personnel accessible extrusion handle operation extrusion ring, extrusion ring along mixing pole slides and realizes crowding the malaria pigment sample of scraping.

Foretell sample mixing application of sample device for raman spectroscopy detects can realize the installation of extrusion handle through the spacing draw-in groove that sets up at the outer wall of extrusion ring, and extrusion handle cover is located the outer wall of extrusion ring and is extruded the handle card and locate spacing draw-in groove, when needs promote the extrusion ring and remove, can drive the extrusion ring through the extrusion handle and remove, and the setting of spacing draw-in groove can restrict the position of extrusion handle, prevents that the extrusion handle from shifting.

Foretell sample mixing application of sample device for raman spectroscopy detects can realize the cooperation of at utmost between extrusion ring and the mixing pole through setting up elastic extrusion ring, because extrusion ring has elasticity, consequently, extrusion ring can easily be attached to and be difficult for taking place to remove on the mixing pole, when extrusion ring needs to remove, can realize removing to the extrusion ring application of force.

Foretell raman spectrum detects with sample mixing application of sample device is spherical structure or ellipsoid structure through setting up mixing vibrations piece, can effectively mix the sample, does not waste simultaneously and mixes remaining sample on vibrations piece 110.

Drawings

In order to more clearly illustrate the technical solutions in the embodiments of the present application, the drawings used in the description of the embodiments will be briefly described below. It is obvious that the drawings in the following description are only some embodiments of the application, and that other drawings can be derived from these drawings by a person skilled in the art without inventive effort.

For a more complete understanding of the present application and its advantages, reference is now made to the following descriptions taken in conjunction with the accompanying drawings. Wherein like reference numerals refer to like parts in the following description.

Fig. 1 is a schematic view of a sample mixing and loading device for raman spectroscopy detection according to an embodiment of the present invention;

fig. 2 is a schematic diagram of a sample mixing and loading device and a centrifuge tube for raman spectroscopy detection according to an embodiment of the present invention.

Description of the reference numerals

10. A sample mixing and loading device for Raman spectrum detection; 100. a blending component; 110. mixing and vibrating part; 120. a mixing rod; 200. an extrusion assembly; 210. an extrusion ring; 211. a limiting clamping groove; 220. squeezing the handle; 221. a grip portion; 300. a vibration driving assembly; 20. and (6) centrifuging the tube.

Detailed Description

In order to make the aforementioned objects, features and advantages of the present invention comprehensible, embodiments accompanied with figures are described in detail below. In the following description, numerous specific details are set forth in order to provide a thorough understanding of the present invention. This invention may, however, be embodied in many different forms and should not be construed as limited to the embodiments set forth herein.

In the description of the present invention, it is to be understood that the terms "central," "longitudinal," "lateral," "length," "width," "thickness," "upper," "lower," "front," "rear," "left," "right," "vertical," "horizontal," "top," "bottom," "inner," "outer," "clockwise," "counterclockwise," "axial," "radial," "circumferential," and the like are used in the orientations and positional relationships indicated in the drawings for convenience in describing the utility model and to simplify the description, and are not intended to indicate or imply that the referenced device or element must have a particular orientation, be constructed and operated in a particular orientation, and are not to be considered limiting of the utility model.

Furthermore, the terms "first", "second" and "first" are used for descriptive purposes only and are not to be construed as indicating or implying relative importance or implicitly indicating the number of technical features indicated. Thus, a feature defined as "first" or "second" may explicitly or implicitly include at least one such feature. In the description of the present invention, "a plurality" means at least two, e.g., two, three, etc., unless specifically limited otherwise.

In the present invention, unless otherwise expressly stated or limited, the terms "mounted," "connected," "secured," and the like are to be construed broadly and can, for example, be fixedly connected, detachably connected, or integrally formed; can be mechanically or electrically connected; they may be directly connected or indirectly connected through intervening media, or they may be connected internally or in any other suitable relationship, unless expressly stated otherwise. The specific meanings of the above terms in the present invention can be understood by those skilled in the art according to specific situations.

In the present invention, unless otherwise expressly stated or limited, the first feature "on" or "under" the second feature may be directly contacting the first and second features or indirectly contacting the first and second features through an intermediate. Also, a first feature "on," "over," and "above" a second feature may be directly or diagonally above the second feature, or may simply indicate that the first feature is at a higher level than the second feature. A first feature being "under," "below," and "beneath" a second feature may be directly under or obliquely under the first feature, or may simply mean that the first feature is at a lesser elevation than the second feature.

It will be understood that when an element is referred to as being "secured to" or "disposed on" another element, it can be directly on the other element or intervening elements may also be present. When an element is referred to as being "connected" to another element, it can be directly connected to the other element or intervening elements may also be present. The terms "vertical," "horizontal," "upper," "lower," "left," "right," and the like as used herein are for illustrative purposes only and do not denote a unique embodiment.

Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs. The terminology used in the description of the utility model herein is for the purpose of describing particular embodiments only and is not intended to be limiting of the utility model. As used herein, the term "and/or" includes any and all combinations of one or more of the associated listed items.

The embodiment of the application provides a sample mixing and sample adding device 10 for Raman spectrum detection, which aims to solve the problems that the existing hemozoin sample is difficult to mix uniformly and the available amount of the mixed hemozoin sample is reduced. The following description will be made with reference to the accompanying drawings.

It should be noted that the hemozoin sample mixing and loading device 10 for raman spectroscopy detection is not limited to the following embodiments, and it should be understood that the hemozoin sample mixing and loading device 10 for raman spectroscopy detection may be used for mixing and loading other samples with small content and difficult mixing in other embodiments.

Fig. 1 is a schematic view of a sample mixing and loading device 10 for raman spectrum detection, where fig. 1 is a schematic view of a structure of the sample mixing and loading device 10 for raman spectrum detection. The sample mixing and loading device 10 for Raman spectrum detection can be used for mixing and loading samples such as malarial pigment. The sample mixing and adding device 10 for Raman spectrum detection can effectively solve the problems that the existing malaria pigment sample is difficult to mix uniformly and the available amount of the mixed malaria pigment sample is reduced, achieves the purposes of good malaria pigment sample mixing effect and small malaria pigment sample mixing loss amount, and realizes the effects of direct sample loading and convenient sample loading after mixing.

In order to more clearly illustrate the structure of the sample mixing and loading device 10 for raman spectroscopy detection, the sample mixing and loading device 10 for raman spectroscopy detection will be described below with reference to the accompanying drawings.

Referring to fig. 1, fig. 1 is a schematic structural diagram of a sample blending and sample adding device 10 for raman spectrum detection according to an embodiment of the present disclosure, and the sample blending and sample adding device 10 for raman spectrum detection includes a blending assembly 100, an extrusion assembly 200, and a vibration driving assembly 300.

The blending assembly 100 includes a blending vibrator 110 and a blending rod 120. One end of the kneading rod 120 is connected to a kneading vibration member 110. The other end of the mixing rod 120 is detachably connected to the vibration driving assembly 300. The extrusion assembly 200 is removably attached to the mixing rod 120 and is capable of moving along the mixing rod 120 to extrude the sample fluid from the mixing rod 120. The mix shaker 110 is adapted to extend into the bottom of the centrifuge tube 20 as shown in FIG. 2. The blending shaking member 110 may be a blending brush. The vibration driving assembly 300 is used for driving the blending rod 120 to vibrate to drive the blending vibrating member 110 to vibrate, so as to achieve blending of the sample liquid in the centrifuge tube 20.

The blending assembly 100 composed of the blending vibration member 110 and the blending rod 120 can be used as a consumable, and the usage rule is disposable.

Illustratively, the compression assembly 200 includes a compression ring 210 and a compression handle 220. The extrusion ring 210 can be sleeved on the kneading rod 120 and can slide along the kneading rod 120. The squeeze grip 220 is connected to the squeeze ring 210. Foretell raman spectroscopy detects with sample mixing application of sample device 10 is through setting up extrusion ring 210 and extrusion handle 220, has made things convenient for operating personnel's operation, and when the application of sample, operating personnel accessible extrusion handle 220 operates extrusion ring 210, and extrusion ring 210 slides along mixing pole 120 and realizes squeezing the malaria pigment sample of scraping.

The connection between the squeeze grip 220 and the squeeze ring 210 may be directly connected or connected through an intervening element. When the squeezing handle 220 is directly connected to the squeezing ring 210, the squeezing handle may be fixedly connected, movably connected, and the like, such as welded, integrally connected, sleeved, and the like.

Illustratively, the squeeze grip 220 is provided with a grip portion 221 for gripping by an operator.

Illustratively, the outer wall of the pressing ring 210 is provided with a limit catch 211. The extrusion handle 220 is sleeved on the outer wall of the extrusion ring 210, and the extrusion handle 220 is clamped in the limit clamping groove 211. Foretell raman spectroscopy detects with sample mixing application of sample device 10 through the spacing draw-in groove 211 that sets up at the outer wall of extrusion ring 210, can realize the installation of extrusion handle 220, extrusion handle 220 cover is located the outer wall of extrusion ring 210 and is extrudeed handle 220 card and locate spacing draw-in groove 211, when needs promote extrusion ring 210 and remove, can drive extrusion ring 210 through extrusion handle 220 and remove, the setting of spacing draw-in groove 211 can restrict the position of extrusion handle 220, prevent that extrusion handle 220 from shifting.

Illustratively, the retaining pockets 211 are outer walls that surround the extrusion ring 210.

Illustratively, the limiting notch 211 is an annular groove that surrounds the outer wall of the extrusion ring 210 by one circle. The annular groove surrounding the outer wall of the pressing ring 210 by one turn can maximally restrict the pressing handle 220, preventing the pressing handle 220 from moving.

Illustratively, the compression ring 210 is resilient. The sample mixing and sample adding device 10 for Raman spectrum detection can realize the maximum matching between the extrusion ring 210 and the mixing rod 120 by arranging the elastic extrusion ring 210, and the extrusion ring 210 has elasticity, so that the extrusion ring 210 can be easily attached to the mixing rod 120 and is not easy to move, and when the extrusion ring 210 needs to move, the extrusion ring 210 can be forced to move.

Illustratively, the crush ring 210 is a cylindrical structure. The outer wall of the extrusion ring 210 narrows from the end of the kneading vibrator 110 to the end of the extrusion ring that is closer to the kneading vibrator 110. For example, the extrusion ring 210 may have a cylindrical configuration, a tapered cylindrical configuration, or the like. It is understood that in other embodiments, the structure and shape of the pressing ring 210 is not limited to the above, and the structure and shape of the pressing ring 210 may also be a polygonal column-like, a sphere-like, an ellipsoid-like structure, or the like.

Illustratively, the vibratory drive assembly 300 is a peristaltic pump.

Illustratively, the kneading shaker 110 has a spherical or ellipsoidal configuration. The sample mixing and sample adding device 10 for Raman spectrum detection is of a spherical structure or an ellipsoidal structure by arranging the mixing vibration member 110, so that samples can be effectively mixed, and residual samples on the mixing vibration member 110 are not wasted.

Illustratively, the blend rod 120 is threadably coupled to the vibratory drive assembly 300. It is understood that in other embodiments, the connection between the mixing rod 120 and the vibratory drive assembly 300 is not limited to the above, and the connection between the mixing rod 120 and the vibratory drive assembly 300 may be a snap fit, or the like, or may be a removable connection via a third centering element.

Foretell raman spectroscopy detects with sample mixing application of sample device 10 has realized the dual purpose of the mixing of malarial pigment sample and application of sample through setting up mixing subassembly 100, extrusion subassembly 200 and vibrations drive assembly 300, can directly carry out the application of sample operation after the malarial pigment sample mixing is finished, need not the step of the application of sample rifle imbibition among the traditional approach, has reduced the loss of malarial pigment sample content, the follow-up demand that detects of being convenient for. When the hemozoin sample needs to be mixed, the vibration driving assembly 300 drives the mixing assembly 100 to move, the mixing rod 120 of the mixing assembly 100 vibrates to drive the mixing vibration member 110 to vibrate, and the vibration of the mixing vibration member 110 drives the mixing of the hemozoin sample in the centrifuge tube 20. When the plasmodium pigment sample needs to be spotted, the connection relation between the vibration driving component 300 and the mixing rod 120 is released, the mixing rod 120 is transferred to a position to be added with sample, the extrusion component 200 is controlled to move along the mixing rod 120 so as to realize that the extrusion component 200 extrudes and scrapes the mixing rod 120, the plasmodium pigment sample liquid on the mixing rod 120 moves downwards along the mixing rod 120, and finally the spotting is carried out through the mixing vibration component 110 at the end part of the mixing rod 120.

In the foregoing embodiments, the descriptions of the respective embodiments have respective emphasis, and for parts that are not described in detail in a certain embodiment, reference may be made to related descriptions of other embodiments.

The technical features of the embodiments described above may be arbitrarily combined, and for the sake of brevity, all possible combinations of the technical features in the embodiments described above are not described, but should be considered as being within the scope of the present specification as long as there is no contradiction between the combinations of the technical features.

The above-mentioned embodiments only express several embodiments of the present invention, and the description thereof is more specific and detailed, but not construed as limiting the scope of the present invention. It should be noted that, for a person skilled in the art, several variations and modifications can be made without departing from the inventive concept, which falls within the scope of the present invention. Therefore, the protection scope of the present patent shall be subject to the appended claims.

Claims (10)

1. The utility model provides a Raman spectrum detects with sample mixing application of sample device, a serial communication port, including mixing subassembly, extrusion subassembly and vibrations drive assembly, the mixing subassembly includes mixing vibrations piece and mixing pole, one of them end connection of mixing pole has mixing vibrations piece, another tip of mixing pole with the detachable connection of vibrations drive assembly, extrusion subassembly detachable connection in mixing pole and can along mixing pole removes and scrapes with squeezing sample liquid on the mixing pole.

2. The Raman spectrum detection sample mixing and adding device according to claim 1, wherein the extrusion assembly comprises an extrusion ring and an extrusion handle, the extrusion ring can be sleeved on the mixing rod and can slide along the mixing rod, and the extrusion handle is connected to the extrusion ring.

3. The sample mixing and adding device for raman spectroscopy according to claim 2, wherein the pressing handle is provided with a holding portion for an operator to hold.

4. The raman spectroscopy detects with sample mixing application of sample device of claim 2, characterized in that, the outer wall of extrusion ring is provided with spacing draw-in groove, the extrusion handle cover is located the outer wall of extrusion ring, just the extrusion handle card is located in the spacing draw-in groove.

5. The sample mixing and loading device for Raman spectrum detection according to claim 4, wherein the limiting clamping groove is an annular groove surrounding the outer wall of the extrusion ring by one circle.

6. The sample mixing and loading device for raman spectroscopy according to claim 2, wherein the pressing ring has elasticity.

7. The sample mixing and adding device for raman spectrum detection according to claim 2, wherein the extrusion ring is of a cylindrical structure, and the outer wall of the extrusion ring gradually narrows from the end far away from the mixing vibration member to the end close to the mixing vibration member.

8. The sample mixing and feeding device for raman spectroscopy according to any one of claims 1 to 7, wherein the vibration driving component is a peristaltic pump.

9. The sample mixing and loading device for raman spectroscopy according to any one of claims 1 to 7, wherein the mixing vibration member has a spherical structure or an ellipsoidal structure.

10. The sample mixing and feeding device for raman spectroscopy according to any one of claims 1 to 7, wherein the mixing rod is in threaded connection with the vibration driving assembly.

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