CN215768617U - Biochemical photoelectric detection system and biochemical analyzer - Google Patents
Biochemical photoelectric detection system and biochemical analyzer Download PDFInfo
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- CN215768617U CN215768617U CN202121462151.0U CN202121462151U CN215768617U CN 215768617 U CN215768617 U CN 215768617U CN 202121462151 U CN202121462151 U CN 202121462151U CN 215768617 U CN215768617 U CN 215768617U
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Abstract
The application relates to a biochemical photoelectric detection system and a biochemical analyzer, the system comprises: the LED light source group and the photoelectric detection module; the LED light source group comprises a plurality of LED light sources; when the plurality of LED light sources are simultaneously lightened, the LED light sources are used for emitting polychromatic light beams covering a preset wavelength range; and the photoelectric detection module is used for simultaneously carrying out monochromatic processing on the polychromatic light beam passing through the detection channel after the polychromatic light beam passes through the detection channel to obtain an optical signal corresponding to the monochromatic light beam with a preset wavelength required by biochemical photoelectric detection. The biochemical photoelectric detection system has the advantages of high detection speed, high detection precision, low cost and small size.
Description
Technical Field
The application relates to the technical field of biochemical photoelectric detection, in particular to a biochemical photoelectric detection system and a biochemical analyzer.
Background
A biochemical analyzer based on spectrophotometry is an analyzer for obtaining various biochemical indexes (such as blood routine, liver function, kidney function, heart function, blood sugar, blood fat, mineral substances and the like) in human body fluid (blood and urine) by utilizing Lambert beer's law, can accurately and quickly provide required test data for doctors and chemical testers, and has important roles in clinical diagnosis and chemical test. The typical components of the biochemical analyzer comprise an optical detection system, a control system and a data processing system; the optical detection system is the premise of rapid and accurate detection of an automatic biochemical analyzer, and in addition, the optical detection system determines the development trend of the analyzer: miniaturization, automation, precision and multi-parameterization. The biochemical analyzer has two photoelectric colorimetric methods: the device comprises a front light splitting technology and a rear light splitting technology, wherein the front light splitting technology is simple in structure and low in cost, but the application of the front light splitting technology in a full-automatic biochemical analyzer is limited due to the low detection speed of the front light splitting technology. At present, a rear light splitting technology is generally adopted by a full-automatic biochemical analyzer, the rear light splitting technology can enable a composite light beam emitted by a light source to pass through a detection channel and then split by a monochromator, biochemical photoelectric detection of a plurality of preset wavelengths can be completed simultaneously, and the detection speed is high. The detection project of the biochemical analyzer is usually used to the wavelength of 300-800nm, and the halogen lamp is used as the light source in the prior art, but the halogen lamp has the defects of short service life, need of replacing the light source regularly, high heat generation and need of designing a special heat dissipation device, so that the development of the biochemical analyzer towards miniaturization and low maintenance cost is limited; the monochromator is a component which enables light with different wavelengths to be diffused at different angles, the monochromator commonly used by the biochemical analyzer is a grating, and the grating as the monochromator has the main defects of high price, secondary spectrum interference analysis and large stray light influence, so that the development of the biochemical analyzer towards low cost and high detection precision is limited.
SUMMERY OF THE UTILITY MODEL
In view of the above, there is a need to provide a biochemical photoelectric detection system and a biochemical analyzer that can achieve high detection speed, high detection accuracy, low cost and small size.
A biochemical photodetection system comprising: the LED light source group and the photoelectric detection module; the LED light source group comprises a plurality of LED light sources;
when the plurality of LED light sources are simultaneously lightened, the LED light sources are used for emitting polychromatic light beams covering a preset wavelength range;
and the photoelectric detection module is used for simultaneously carrying out monochromatic processing on the polychromatic light beam passing through the detection channel after the polychromatic light beam passes through the detection channel to obtain an optical signal corresponding to the monochromatic light beam with a preset wavelength required by biochemical photoelectric detection.
In one embodiment, the number of the LED light source groups is at least two; the system further comprises: a light combining element;
each LED light source group is used for emitting incident light beams with at least one preset wavelength required by biochemical photoelectric detection;
the light combination element is used for combining the incident light beams to obtain the polychromatic light beams covering the preset wavelength range.
In one embodiment, the system further comprises a condenser lens group; the arrangement position of the condenser lens group includes at least one of:
the LED light source group and the light combining element are arranged between the LED light source group and the light combining element;
the light combining element is arranged between the light combining element and the detection channel;
the detection channel and the photoelectric detection module.
In one embodiment, the photodetection module comprises a multispectral sensor; the multispectral sensor is a photoelectric detector array with a plurality of light filtering films plated on the surface;
the polychromatic light beams passing through the detection channel are incident to the multispectral sensor, the incident polychromatic light beams are subjected to monochromatic processing by the filter films respectively to obtain monochromatic light beams with corresponding preset wavelengths, and each photoelectric detector in the photoelectric detector array receives optical signals of the monochromatic light beams with the corresponding preset wavelengths.
In one embodiment, the photoelectric detection module comprises a multispectral sensor, a light splitting element and a photoelectric detector; the multispectral sensor is a photoelectric detector array with a plurality of light filtering films plated on the surface;
the light splitting element is used for splitting the polychromatic light beam passing through the detection channel into two beams, one beam of monochromatic light beam generating a first preset wavelength and acting on the photoelectric detector to obtain an incident optical signal of the monochromatic light beam with the first preset wavelength, the other beam of monochromatic light beam acting on the filter membrane of the multispectral sensor to obtain a corresponding monochromatic light beam with a second preset wavelength, and each photoelectric detector in the photoelectric detector array receives an optical signal of the monochromatic light beam corresponding to the second preset wavelength; the first preset wavelength is different from the second preset wavelength.
In one embodiment, the photodetection module further comprises: a beam expander; the beam expander is arranged between the light splitting element and the multispectral sensor.
In one embodiment, the photoelectric detection module comprises a light splitting element, a plurality of optical filters and a photoelectric detector corresponding to each optical filter; each optical filter is used for transmitting monochromatic light beams with preset wavelength required by biochemical photoelectric detection, and the monochromatic light beams transmitted through each optical filter correspond to monochromatic light beams with different preset wavelengths
The light splitting element is used for splitting the polychromatic light beams passing through the detection channel to obtain a plurality of polychromatic light beams which are respectively incident to the corresponding optical filters;
each optical filter is used for carrying out monochromatic processing on the incident polychromatic light beam to obtain monochromatic light beams with corresponding preset wavelengths;
each of the photodetectors is configured to receive an optical signal of a monochromatic light beam of a corresponding predetermined wavelength.
In one embodiment, the predetermined wavelength required for the biochemical photoelectric detection is one or more of 340nm, 380nm, 405nm, 450nm, 480nm, 500nm, 545nm, 570nm, 600nm, 660nm, 700nm, 750nm and 800 nm.
In one embodiment, the LED light sources in each LED light source group are arranged in a circle.
The biochemical photoelectric detection system adopts the LED light source group comprising the LED light sources as the system light source, and the LED light source has the advantages of long service life, no need of replacing the light source regularly, low heat generation, no need of designing a special heat dissipation device, and small size and low cost. In addition, when a plurality of LED light sources in the LED light source group are simultaneously lightened, the LED light source group emits the polychromatic light beam covering the preset wavelength range and is incident to the detection channel, the monochromatic light beam passing through the detection channel is simultaneously subjected to monochromatic processing through the photoelectric detection module to obtain monochromatic light beams with various preset wavelengths required by biochemical photoelectric detection, and optical signals of the monochromatic light beams with various preset wavelengths are received, so that the biochemical photoelectric detection under the corresponding preset wavelengths is simultaneously realized on the basis of the received optical signals of the monochromatic light beams with various preset wavelengths, and the detection speed can be improved. In addition, the biochemical photoelectric detection system adopts the photoelectric detection module as the monochromator and the photoelectric detector, and does not adopt the grating as the monochromator, so that the problem that the system is limited to develop towards the direction of low cost and high detection precision due to the adoption of the grating as the monochromator can be avoided. In summary, the biochemical photoelectric detection system provided by the utility model has the advantages of high detection speed, high detection precision, low cost and small size.
A biochemical analyzer comprises the biochemical photoelectric detection system provided in the system embodiments.
The biochemical photoelectric detection system provided in the above embodiment has the advantages of high detection speed, high detection precision, low cost and small size, so that the biochemical analyzer using the biochemical photoelectric detection system also has the advantages of high detection speed, high detection precision, low cost and small size.
Drawings
FIG. 1 is a schematic diagram of the structure of a biochemical photoelectric detection system in one embodiment;
FIG. 2 is a schematic diagram of an optical path structure of a biochemical photoelectric detection system in one embodiment;
FIG. 3 is a schematic cross-sectional view of a plurality of LED light sources arranged circumferentially in one embodiment;
FIG. 4 is a schematic diagram of an optical path structure of a biochemical photoelectric detection system in another embodiment;
FIG. 5 is a schematic diagram of an optical path structure of a biochemical photoelectric detection system in yet another embodiment;
FIG. 6 is a schematic diagram of an optical path structure of a biochemical photoelectric detection system in yet another embodiment;
FIG. 7 is a schematic diagram of an optical path structure of a biochemical photoelectric detection system in yet another embodiment.
Detailed Description
In order to make the objects, technical solutions and advantages of the present application more apparent, the present application is described in further detail below with reference to the accompanying drawings and embodiments. It should be understood that the specific embodiments described herein are merely illustrative of the present application and are not intended to limit the present application.
In one embodiment, as shown in FIG. 1, there is provided a biochemical photodetection system comprising: the LED light source group 100 and the photodetection module 200; the LED light source group 100 includes a plurality of LED light sources; the LED light sources are used for emitting polychromatic light beams covering a preset wavelength range when the LED light sources are simultaneously lightened; the photoelectric detection module 200 is configured to perform monochromatic processing on the polychromatic light beam after passing through the detection channel after the polychromatic light beam passes through the detection channel, so as to obtain an optical signal corresponding to the monochromatic light beam with a preset wavelength required by the biochemical photoelectric detection.
The simultaneous lighting means that the LED light sources in the LED light source group are simultaneously lighted, that is, the states of the LED light sources are synchronous, or all are in a lighted state, or all are in a non-lighted state. The LED light source group comprises a plurality of LED light sources, each LED light source is used for emitting incident light beams with at least one preset wavelength required by biochemical photoelectric detection, and the polychromatic light beams covering a preset wavelength range can be obtained based on the incident light beams emitted by the LED light sources. The LED light source may be a broad spectrum LED lamp, such as a broad spectrum LED lamp with a wavelength range of 400nm-1000nm (nanometers, a length measurement unit), a single color LED lamp, such as a single color LED lamp with a wavelength of 340nm or 380nm, a multi-color LED lamp, such as a multi-color LED lamp with a wavelength range of 720nm-820nm, or a white light LED lamp, such as a white light LED lamp with a wavelength range of 400nm-740nm, which is not limited herein. The preset wavelength range is a wavelength range or an interval covering various preset wavelengths required for biochemical photoelectric detection, for example, 300nm to 800nm, so that biochemical photoelectric detection at each preset wavelength can be realized based on the polychromatic light beam covering the preset wavelength range.
Be provided with detection device in the measuring channel, detection device specifically can be the cell or the color disc that includes a plurality of cells, the material that awaits measuring that awaits biochemical photoelectric detection is equipped with in the cell, like this, the polychromatic light beam that LED light source group emitted passes through the measuring channel, can transmit the material that awaits measuring in the cell that sets up in this measuring channel, from this, polychromatic light beam after passing through the measuring channel is promptly for transmitting the polychromatic light beam of the material that awaits measuring, based on this polychromatic light beam of transmitting the material that awaits measuring, can realize the biochemical photoelectric detection of the material that awaits measuring under each preset wavelength. The polychromatic light beams emitted by a plurality of LED light sources in the LED light source group are incident to the photoelectric detection module after passing through the detection channel, and the photoelectric detection module performs monochromatic processing on the incident polychromatic light beams to obtain optical signals corresponding to the monochromatic light beams with preset wavelengths required by biochemical photoelectric detection.
In one embodiment, the predetermined wavelength required for biochemical photodetection includes, but is not limited to, one or more of 340nm, 380nm, 405nm, 450nm, 480nm, 500nm, 545nm, 570nm, 600nm, 660nm, 700nm, 750nm, and 800 nm.
In one embodiment, for example, the predetermined wavelength range is 300nm to 800nm, the polychromatic light beam covering the predetermined wavelength range can be obtained by combining at least three LED light sources. For example, the light beam with the wavelength of 300nm to 800nm can be covered by the combination of a broad spectrum LED lamp with the wavelength range of 400nm to 1000nm, a monochromatic LED lamp with the wavelength of 340nm, a monochromatic LED lamp with the wavelength of 380nm, a polychromatic LED lamp with the wavelength range of 720nm to 820nm and a white light LED lamp with the wavelength range of 400nm to 740nm, or the combination of monochromatic LED lamps with the wavelengths of 340nm, 380nm, 405nm, 450nm, 480nm, 500nm, 545nm, 570nm, 600nm, 660nm, 700nm, 750nm and 800 nm. It is to be understood that the combination of the LED light sources is not limited to the above examples.
The biochemical photoelectric detection system adopts the LED light source group comprising the LED light sources as the system light source, and the LED light source has the advantages of long service life, no need of replacing the light source regularly, low heat generation, no need of designing a special heat dissipation device, and small size and low cost. In addition, when a plurality of LED light sources in the LED light source group are simultaneously lightened, the LED light source group emits the polychromatic light beam covering the preset wavelength range and is incident to the detection channel, the monochromatic light beam passing through the detection channel is simultaneously subjected to monochromatic processing through the photoelectric detection module to obtain monochromatic light beams with various preset wavelengths required by biochemical photoelectric detection, and optical signals of the monochromatic light beams with various preset wavelengths are received, so that the biochemical photoelectric detection under the corresponding preset wavelengths is simultaneously realized on the basis of the received optical signals of the monochromatic light beams with various preset wavelengths, and the detection speed can be improved. In addition, the biochemical photoelectric detection system adopts the photoelectric detection module as the monochromator and the photoelectric detector, and does not adopt the grating as the monochromator, so that the problem that the system is limited to develop towards the direction of low cost and high detection precision due to the adoption of the grating as the monochromator can be avoided. In summary, the biochemical photoelectric detection system has the advantages of high detection speed, high detection precision, low cost and small size.
In one embodiment, the number of LED light source groups is at least two; the biochemical photoelectric detection system further comprises: a light combining element; each LED light source group is used for emitting incident light beams with at least one preset wavelength required by biochemical photoelectric detection; the light combination element is used for combining the incident light beams to obtain the polychromatic light beams covering the preset wavelength range.
Each LED light source group comprises at least one LED light source, each LED light source emits incident light beams with at least one preset wavelength required by biochemical photoelectric detection, therefore, each LED light source group can be used for emitting incident light beams with at least one preset wavelength required by biochemical photoelectric detection, and the polychromatic light beams covering a preset wavelength range can be obtained based on the incident light beams emitted by the LED light source groups. When the LED light source group includes more than one LED light source, the incident light beams emitted by the more than one LED light sources are totally incident on the light combining element as the incident light beams finally emitted by the corresponding LED light source group. The light combining element is used for combining incident light beams emitted by the LED light source groups into a complex color light beam.
In one embodiment, when the polychromatic light beam covering the predetermined wavelength range is obtained by combining a broad spectrum LED lamp with a wavelength range of 400nm-1000nm, a monochromatic LED lamp with a wavelength of 340nm and a monochromatic LED lamp with a wavelength of 380nm, the three LED light sources may be combined into one or more LED light source groups, such as a single LED light source group comprising the three LED light sources at the same time, or each LED light source group comprising one of the LED light sources, or one LED light source group comprising one of the LED light sources and one LED light source group comprising the remaining two LED light sources. Similarly, for other LED light source combination modes capable of obtaining a polychromatic light beam covering a preset wavelength range, one or more LED light source groups can be obtained by combination, which is not listed here.
In one embodiment, as shown in fig. 2, a schematic diagram of an optical path structure of a biochemical photoelectric detection system is provided. The biochemical photoelectric detection system comprises: the LED light source group 100, the photodetection module 200, and the light combining element 300, wherein there are two LED light source groups 100, which are respectively represented by reference numerals 101 and 102, the detection channel is represented by 000, the light combining element 300 is disposed between the LED light source group 100 and the detection channel 000, and is configured to combine incident light beams emitted by the LED light source group 101 and the LED light source group 102, the combined light beam is a polychromatic light beam covering a preset wavelength range, the polychromatic light beam passes through the detection channel 000 and then enters the photodetection module 200, the photodetection module 200 performs monochromatic processing on the incident polychromatic light beam, and obtains an optical signal corresponding to the monochromatic light beam with a preset wavelength required for biochemical photoelectric detection.
It is understood that the number of LED light source sets, the types and number of light combining elements, and the like in fig. 2 are only examples, and are not limited to specific limitations. For example, when the light combining element is a dichroic mirror, each additional LED light source group is added with a dichroic mirror, so as to combine the incident light beams emitted by the additional LED light source group into the polychromatic light beam.
In one embodiment, the LED light sources in each LED light source group are arranged in a circle. For the LED light source group comprising a plurality of LED light sources, the LED light sources in the LED light source group are arranged in a circumferential manner, and the LED light sources in the LED light source group are arranged in a circumferential arrangement manner, so that the arrangement of the LED light sources is more compact, and the size of the LED light source group can be reduced.
As shown in fig. 3, in an embodiment, a schematic cross-sectional view of a plurality of LED light sources arranged in a circle is provided, and taking an example that an LED light source group includes 7 LED light sources, the 7 LED light sources are arranged in a circle, wherein 1 LED light source is located at a center of the circle, and the remaining 6 LED light sources are uniformly arranged on the circle around the center of the circle. It is understood that the number of LED light sources and the circumferential disposition of the LED light sources shown in fig. 3 are only examples, and are not limited to specific limitations, for example, the 7 LED light sources are all uniformly distributed on the circumference.
In one embodiment, the biochemical photoelectric detection system further comprises a condenser lens group; the arrangement position of the condenser lens group includes at least one of: the LED light source group and the light combination element; the light combining element and the detection channel; between the detection channel and the photoelectric detection module.
The condensing lens group includes one or more condensing lenses, and the condensing lens may specifically be a spherical lens and/or an aspheric lens, and when the condensing lens group includes a plurality of condensing lenses, the condensing lens group may specifically be a plurality of spherical lenses or a plurality of aspheric lenses, or a combination of a spherical lens and an aspheric lens. The light beams incident to the condenser lens group are condensed or focused through the condenser lens group, so that the energy of the light beams is more uniform, and the energy utilization rate can be improved.
In one embodiment, the photodetection module comprises a multispectral sensor; the multispectral sensor is a photoelectric detector array with a plurality of light filtering films plated on the surface; the polychromatic light beam passing through the detection channel is incident to the multi-spectral sensor, the incident polychromatic light beam transmits through each filter film to obtain monochromatic light beams with corresponding preset wavelengths, and each photoelectric detector in the photoelectric detector array receives optical signals of the monochromatic light beams with corresponding preset wavelengths.
The photodetector array may be specifically an annular photodetector array or a rectangular photodetector array, where the annular photodetector array refers to that more than one photodetectors are arranged in a circular ring, and the matrix photodetector array refers to that more than one photodetectors are arranged in a matrix, and it is understood that the arrangement and arrangement manner of more than one photodetectors is not limited to the above example, and may also be arranged in a circumferential manner, for example.
The light filtering films are respectively coated on each photoelectric detector in the multispectral sensor, each light filtering film can transmit monochromatic light beams with preset wavelength required by biochemical photoelectric detection, and the corresponding preset wavelengths of the monochromatic light beams transmitted through the light filtering films are different. The polychromatic light beams passing through the detection channel are simultaneously incident to the filter coatings in the multispectral sensor, and the filter coatings respectively perform monochromatic processing on the incident polychromatic light beams, so that the monochromatic light beams with preset wavelengths can respectively transmit the corresponding filter coatings, and the photodetectors coated with the filter coatings respectively receive optical signals of the monochromatic light beams transmitting the corresponding filter coatings, so that biochemical photoelectric detection under the preset wavelengths can be simultaneously realized on the basis of the received optical signals of the monochromatic light beams with the preset wavelengths, and the detection speed can be improved.
As shown in fig. 4, in one embodiment, a schematic diagram of an optical path structure of a biochemical photoelectric detection system is provided. The biochemical photoelectric detection system comprises: the LED light source assembly 100, the photodetection module 200, the light combining element 300 and the condensing lens assembly 400, wherein there are three LED light source assemblies 100, which are respectively represented by reference numerals 101, 102 and 103, and two light combining elements 300, which are respectively represented by reference numerals 301 and 302, are used for combining incident light beams emitted by the three LED light source assemblies into a composite color light beam, and the detection channel is represented by 000, the photodetection module 200 includes the multispectral sensor 210, and in addition, the condensing lens assembly 400 is disposed between the LED light source assemblies 101 and the light combining element 301, between the LED light source assemblies 102 and the light combining element 301, between the LED light source assemblies 103 and the light combining element 302, between the light combining element 302 and the detection channel 000, and between the detection channel 000 and the multispectral sensor 210, and the light combining element 302 is disposed behind the light combining element 301 with reference to the light beam propagation direction.
It is understood that the number of LED light source sets, the type and number of light combining elements, the number and arrangement positions of the condenser lens sets, and the like in fig. 4 are only examples and are not limited to specific limitations. For example, one or more of the condenser lens groups shown in fig. 4 may be reduced as the case may be.
In one embodiment, when there are at least two LED light source groups, a condenser lens group may be disposed between each LED light source group and the light combining element, or only a condenser lens group may be disposed between the LED light source group including a plurality of LED light sources and the light combining element, which is not limited herein.
In one embodiment, the photoelectric detection module comprises a multispectral sensor, a light splitting element and a photoelectric detector; the multispectral sensor is a photoelectric detector array with a plurality of light filtering films plated on the surface; the light splitting element is used for splitting the polychromatic light beam passing through the detection channel into two beams, one beam generates a monochromatic light beam with a first preset wavelength and acts on the photoelectric detector to obtain an incident optical signal of the monochromatic light beam with the first preset wavelength, the other beam acts on the filter membrane of the multispectral sensor to obtain a corresponding monochromatic light beam with a second preset wavelength, and each photoelectric detector in the photoelectric detector array receives an optical signal of the monochromatic light beam with the second preset wavelength; the first predetermined wavelength is different from the second predetermined wavelength.
The light splitting element can be used for splitting the incident polychromatic light beam into two beams, one beam is a monochromatic light beam with a first preset wavelength, the other beam is a polychromatic light beam which is separated out of the first preset wavelength and covers a second preset wavelength, and the light splitting element can be a light splitting mirror or a dichroic mirror. The first preset wavelength and the second preset wavelength are both preset wavelengths required by biochemical photoelectric detection, and the first preset wavelength is different from the second preset wavelength, the first preset wavelength may be a preset wavelength with weaker light energy, such as 340nm, and the second preset wavelength may be a preset wavelength with stronger light energy, such as one or more of 380nm, 405nm, 450nm, 480nm, 500nm, 545nm, 570nm, 600nm, 660nm, 700nm, 750nm, and 800 nm. The multispectral sensor is a photodetector array with a plurality of filter films plated on the surface, each filter film can transmit monochromatic light beams with a second preset wavelength required by biochemical photoelectric detection, and the second preset wavelengths corresponding to the monochromatic light beams transmitted through the filter films are different, so that the incident polychromatic light beams are subjected to monochromatic processing based on the filter films, and the monochromatic light beams with the second preset wavelengths can be obtained.
The monochromatic light beam with the first preset wavelength obtained by light splitting of the light splitting element is incident to the photoelectric detector, and the photoelectric detector receives an optical signal of the incident monochromatic light beam with the first preset wavelength. The polychromatic light beam obtained by light splitting of the light splitting element enters the multispectral sensor, monochromatic processing is carried out on the incident polychromatic light beam through a plurality of filter films in the multispectral sensor at the same time to obtain monochromatic light beams with second preset wavelengths, and each photoelectric detector in the photoelectric detector array receives optical signals of the monochromatic light beams transmitted through the corresponding filter film.
In one embodiment, the light splitting element may also be configured to split the incident polychromatic light beam into two polychromatic light beams, where the two polychromatic light beams are the same and cover both the first predetermined wavelength and the second predetermined wavelength, or one polychromatic light beam covers the first predetermined wavelength and the other polychromatic light beam covers the second predetermined wavelength.
In this embodiment, in the biochemical photoelectric detection system, the light splitting element may be a fiber bundle, a beam splitter or a dichroic mirror, and an optical filter capable of transmitting the monochromatic light beam with the first preset wavelength is disposed between the light splitting element and the photodetector, or a filter coating of the photodetector is coated with the monochromatic light beam with the first preset wavelength, so that when the polychromatic light beam with the first preset wavelength transmits through the optical filter or the filter coating, the monochromatic light beam with the first preset wavelength can be obtained, and thus, the photodetector can receive the optical signal of the monochromatic light beam with the first preset wavelength. The polychromatic light beam covering the second preset wavelength enters the multispectral sensor, each filter film in the multispectral sensor simultaneously performs monochromatic processing on the incident polychromatic light beam to obtain a monochromatic light beam with the second preset wavelength, and each photoelectric detector in the multispectral sensor receives an optical signal of the monochromatic light beam with the second preset wavelength.
In one embodiment, the photodetection module further comprises: a beam expander; the beam expander is arranged between the light splitting element and the multispectral sensor.
The beam expander expands the incident polychromatic light beam, the expanded polychromatic light beam enters the multispectral sensor, and the multispectral sensor acquires optical signals of the monochromatic light beams with the second preset wavelengths based on the incident polychromatic light beam. It can be understood that the size of the multispectral sensor is limited by the spot size of the incident polychromatic light beam, the spot size of the polychromatic light beam incident to the multispectral sensor is generally small, and therefore the incident polychromatic light beam is generally required to be received and processed by the multispectral sensor with the small size, so that the cost of the multispectral sensor is relatively increased, and the cost of the biochemical photoelectric detection is relatively increased.
As shown in fig. 5, in one embodiment, a schematic diagram of an optical path structure of a biochemical photoelectric detection system is provided. The biochemical photoelectric detection system comprises: the LED light source assembly 100, the photodetection module 200, the light combining element 300, and the condenser lens assembly 400, wherein there are two LED light source assemblies 100, which are respectively represented by reference numerals 101 and 102, the detection channel is represented by 000, the photodetection module 200 includes a multispectral sensor 210, a light splitting element 211, a photodetector 212, and a beam expander 213, in addition, the condenser lens assembly 400 is disposed between the LED light source assembly 101 and the light combining element 300, between the LED light source assembly 102 and the light combining element 300, between the light combining element 300 and the detection channel 000, between the detection channel 000 and the light splitting element 211, and between the light splitting element 211 and the photodetector 212, and the beam expander 213 is disposed between the light splitting element 211 and the multispectral sensor 210.
It is understood that the number of LED light source sets, the type and number of light combining elements, the number and arrangement positions of the condenser lens sets, and the like in fig. 5 are only examples and are not limited to specific limitations. For example, one or more of the condenser lens groups shown in fig. 5 may be reduced as the case may be. It should be noted that, if the light beam received by the condenser lens group between the light splitting element and the photodetector is a polychromatic light beam covering a first preset wavelength, an optical filter may be disposed at any position between the light splitting element and the photodetector, and the optical filter may perform monochromatic processing on the incident polychromatic light beam to obtain a monochromatic light beam of the first preset wavelength.
In one embodiment, the photoelectric detection module comprises a light splitting element, a plurality of optical filters and a photoelectric detector corresponding to each optical filter; each optical filter is used for transmitting monochromatic light beams with a preset wavelength required by biochemical photoelectric detection, and the corresponding preset wavelengths of the monochromatic light beams transmitted through the optical filters are different; the light splitting element is used for splitting the polychromatic light beams passing through the detection channel to obtain a plurality of polychromatic light beams which are respectively incident to the corresponding optical filters; each optical filter is used for carrying out monochromatic processing on the incident polychromatic light beam to obtain monochromatic light beams with corresponding preset wavelengths; each photodetector is used for receiving the optical signal of the monochromatic light beam with the corresponding preset wavelength.
The light splitting element may be a fiber bundle, a light splitting sheet, or a dichroic mirror. It is understood that when the light splitting element is a fiber bundle, the number of the light splitting elements is independent of the number of the polychromatic light beams required by light splitting, for example, the polychromatic light beams passing through the detection channel can be simultaneously split into a plurality of polychromatic light beams by one monochromatic light beam and a plurality of optical fiber beams. When the light splitting element is a light splitting sheet or a dichroic mirror, the number of the light splitting elements is one less than the number of the polychromatic light beams required to be obtained by light splitting, for example, if the polychromatic light beams passing through the detection channel need to be split into two light splitting elements, one light splitting element needs to be arranged, if the polychromatic light beams passing through the detection channel need to be split into three light splitting elements, two light splitting elements need to be arranged, and so on, which are not listed herein.
In the case where the light splitting element is a light splitting plate or a dichroic mirror, when there are more than one light splitting elements, the combination manner and the relative positional relationship between the light splitting elements are not particularly limited as long as the light splitting element can split the polychromatic light beam passing through the detection channel into a plurality of polychromatic light beams, and the plurality of filters and the corresponding photodetectors can obtain optical signals corresponding to monochromatic light beams of preset wavelengths required for biochemical photoelectric detection, based on the plurality of polychromatic light beams, for example, the polychromatic light beam passing through the detection channel is split into two light beams by one light splitting element, and one of the split polychromatic light beams is split into two light beams by another light splitting element, so that the polychromatic light beam passing through the detection channel can be split into three polychromatic light beams by the combination of the two light splitting elements.
The light splitting element splits the polychromatic light beams passing through the detection channel into a plurality of polychromatic light beams, each polychromatic light beam is respectively incident to one optical filter, each optical filter performs monochromatic processing on the incident polychromatic light beam to obtain monochromatic light beams with corresponding preset wavelengths, and each photoelectric detector receives optical signals of the monochromatic light beams transmitted through the corresponding optical filters.
As shown in fig. 6, in one embodiment, a schematic diagram of an optical path structure of a biochemical photoelectric detection system is provided. The biochemical photoelectric detection system comprises: the LED light source assembly 100, the photodetection module 200, the light combining element 300, and the condenser lens assembly 400, wherein there are two LED light source assemblies 100, which are respectively represented by reference numerals 101 and 102, and the detection channel is represented by 000, the photodetection module 200 includes a light splitting element 220, two filters 221 and photodetectors 222, the light splitting element 220 is a two-into-one optical fiber bundle, and is configured to split the incident polychromatic light beam into two polychromatic light beams, which are respectively incident to the filters 221, there are two filters 221 and photodetectors 222, each filter 221 can transmit a monochromatic light beam with a preset wavelength required for biochemical photoelectric detection, the monochromatic light beams transmitted through each filter 221 have different preset wavelengths, and each photodetector 222 is configured to receive an optical signal of the monochromatic light beam transmitted through the corresponding filter 221. In addition, the condensing lens assembly 400 is disposed between the LED light source set 101 and the light combining element 300, between the LED light source set 102 and the light combining element 300, between the light combining element 300 and the detection channel 000, and between the detection channel 000 and the light splitting element 220.
As shown in fig. 7, in one embodiment, a schematic diagram of an optical path structure of a biochemical photoelectric detection system is provided. The biochemical photoelectric detection system comprises: an LED light source group 100, a photoelectric detection module 200, a light combining element 300 and a condenser lens group 400, wherein, there are three LED light source sets 100, which are respectively represented by reference numerals 101, 102 and 103, there are two light combining elements 300, which are respectively represented by reference numerals 301 and 302, the detection channel is represented by 000, the photodetection module 200 includes a light splitting element 220, an optical filter 221 and a photodetector 222, the light splitting element 220 is a one-to-four optical fiber bundle, the light source module is configured to divide the incident polychromatic light beam into four polychromatic light beams, and the polychromatic light beams are respectively incident to the optical filters 221, where the number of the optical filters 221 and the number of the photodetectors 222 are four, each optical filter 221 can be configured to transmit a monochromatic light beam with a preset wavelength required by biochemical photoelectric detection, the preset wavelengths corresponding to the monochromatic light beams transmitted through each optical filter 221 are different, and each photodetector 222 is configured to receive an optical signal transmitted through the monochromatic light beam of the corresponding optical filter 221. In addition, the condensing lens group 400 is disposed between the LED light source set 101 and the light combining element 301, between the LED light source set 102 and the light combining element 301, between the LED light source set 103 and the light combining element 302, between the light combining element 302 and the detection channel 000, between the detection channel 000 and the light splitting element 220, between the light splitting element 220 and each filter 221, and between each filter 221 and the corresponding photodetector 222. The light combining element 302 is disposed behind the light combining element 301 with reference to the propagation direction of the light beam.
It is to be understood that the number of LED light source sets, the type and number of light combining elements, the type and number of light splitting elements, the number and arrangement positions of the light collecting lens groups, and when the light splitting element is an optical fiber bundle, the number of polychromatic light beams split by the optical fiber bundle, and the number of correspondingly arranged filters and photodetectors in fig. 6 and 7 are only used as examples and are not limited to specific limitations. For example, one or more of the condenser lens groups shown in fig. 6 and 7 may be reduced according to practical situations.
It should be noted that, if the biochemical photoelectric detection system is required to be capable of realizing biochemical photoelectric detection under a preset number of preset wavelengths, the fiber bundle is required to split the polychromatic light beam incident to the fiber bundle into a preset number of polychromatic light beams, so that monochromatic processing is performed on the preset number of polychromatic light beams through a preset number of optical filters, monochromatic light beams with each preset wavelength are obtained, and biochemical photoelectric detection under a corresponding preset wavelength is realized based on an optical signal of the monochromatic light beam with each preset wavelength. For example, if the biochemical photoelectric detection system is required to be capable of realizing biochemical photoelectric detection at 13 preset wavelengths, a thirteen-split optical fiber bundle is required to split the incident polychromatic light beam into 13 polychromatic light beams.
It should be understood that, in the schematic diagrams of the optical path structures shown in fig. 2, 4, 5, 6 and 7, the schematic structures and shapes of the optical elements are only used as examples and are not intended to be specifically limited, and the relative distances between the optical elements in the schematic diagrams of the optical path structures are only used as examples and are not intended to be specifically limited to the actual relative distances in the biochemical photoelectric detection system.
In one embodiment, a cuvette comprising a plurality of cuvettes is disposed in the detection channel; and the colorimetric discs are rotated to enable the colorimetric cups to be sequentially transmitted by the polychromatic light beams incident to the detection channels.
Wherein, set up the detection device in the measuring channel specifically can be the color comparison disc, be provided with a plurality of cuvettes on the color comparison disc, the color comparison disc can rotate, makes each cuvette on this color comparison disc in proper order by the transmission of the polychromatic light beam of inciding to the measuring channel through rotating the color comparison disc, from this, can realize the biochemical photoelectric detection to the material that awaits measuring in this color comparison disc based on the polychromatic light beam after transmitting the color comparison disc. Therefore, the biochemical photoelectric detection can be efficiently completed by setting the rotating speed of the colorimetric disc, so that the full-automatic high-speed biochemical photoelectric detection can be realized.
In one embodiment, a biochemical analyzer is provided that includes the biochemical photodetection system provided in the system embodiments described above.
The biochemical photoelectric detection system provided in one or more embodiments above may be applied to a biochemical analyzer, so that the biochemical analyzer realizes biochemical photoelectric detection corresponding to each preset wavelength based on the biochemical photoelectric detection system. The biochemical photoelectric detection system provided in the above embodiment has the advantages of high detection speed, high detection precision, low cost and small size, so that the biochemical analyzer using the biochemical photoelectric detection system also has the advantages of high detection speed, high detection precision, low cost and small size
The technical features of the above embodiments can be arbitrarily combined, and for the sake of brevity, all possible combinations of the technical features in the above embodiments are not described, but should be considered as the scope of the present specification as long as there is no contradiction between the combinations of the technical features.
The above-mentioned embodiments only express several embodiments of the present application, and the description thereof is more specific and detailed, but not understood as the description thereof
Limitations of the utility model patent scope. It should be noted that, for a person skilled in the art, several variations and modifications can be made without departing from the concept of the present application, which falls within the scope of protection of the present application. Therefore, the protection scope of the present patent shall be subject to the appended claims.
Claims (10)
1. A biochemical photodetecting system, characterized in that it comprises: the LED light source group and the photoelectric detection module; the LED light source group comprises a plurality of LED light sources;
when the plurality of LED light sources are simultaneously lightened, the LED light sources are used for emitting polychromatic light beams covering a preset wavelength range;
and the photoelectric detection module is used for simultaneously carrying out monochromatic processing on the polychromatic light beam passing through the detection channel after the polychromatic light beam passes through the detection channel to obtain an optical signal corresponding to the monochromatic light beam with a preset wavelength required by biochemical photoelectric detection.
2. The system of claim 1, wherein the LED light source groups are at least two; the system further comprises: a light combining element;
each LED light source group is used for emitting incident light beams with at least one preset wavelength required by biochemical photoelectric detection;
the light combination element is used for combining the incident light beams to obtain the polychromatic light beams covering the preset wavelength range.
3. The system of claim 2, further comprising a collection lens group; the arrangement position of the condenser lens group includes at least one of:
the LED light source group and the light combining element are arranged between the LED light source group and the light combining element;
the light combining element is arranged between the light combining element and the detection channel;
the detection channel and the photoelectric detection module.
4. The system according to any one of claims 1 to 3, wherein the photodetection module comprises a multispectral sensor; the multispectral sensor is a photoelectric detector array with a plurality of light filtering films plated on the surface; the polychromatic light beams passing through the detection channel are incident to the multispectral sensor, the incident polychromatic light beams are subjected to monochromatic processing by the filter films respectively to obtain monochromatic light beams with corresponding preset wavelengths, and each photoelectric detector in the photoelectric detector array receives optical signals of the monochromatic light beams with the corresponding preset wavelengths.
5. The system according to any one of claims 1 to 3, wherein the photodetection module comprises a multispectral sensor, a light splitting element, and a photodetector; the multispectral sensor is a photoelectric detector array with a plurality of light filtering films plated on the surface;
the light splitting element is used for splitting the polychromatic light beam passing through the detection channel into two beams, one beam of monochromatic light beam generating a first preset wavelength and acting on the photoelectric detector to obtain an incident optical signal of the monochromatic light beam with the first preset wavelength, the other beam of monochromatic light beam acting on the filter membrane of the multispectral sensor to obtain a corresponding monochromatic light beam with a second preset wavelength, and each photoelectric detector in the photoelectric detector array receives an optical signal of the monochromatic light beam corresponding to the second preset wavelength; the first preset wavelength is different from the second preset wavelength.
6. The system of claim 5, wherein the photodetection module further comprises: a beam expander; the beam expander is arranged between the light splitting element and the multispectral sensor.
7. The system according to any one of claims 1 to 3, wherein the photodetection module comprises a light splitting element and a plurality of filters, and a photodetector corresponding to each filter; each optical filter is used for transmitting monochromatic light beams with a preset wavelength required by biochemical photoelectric detection, and the corresponding preset wavelengths of the monochromatic light beams transmitted through the optical filters are different;
the light splitting element is used for splitting the polychromatic light beams passing through the detection channel to obtain a plurality of polychromatic light beams which are respectively incident to the corresponding optical filters;
each optical filter is used for carrying out monochromatic processing on the incident polychromatic light beam to obtain monochromatic light beams with corresponding preset wavelengths;
each of the photodetectors is configured to receive an optical signal of a monochromatic light beam of a corresponding predetermined wavelength.
8. The system of claim 1, wherein the predetermined wavelength required for the biochemical photodetection is one or more of 340nm, 380nm, 405nm, 450nm, 480nm, 500nm, 545nm, 570nm, 600nm, 660nm, 700nm, 750nm, and 800 nm.
9. The system of claim 1, wherein the LED light sources within each LED light source group are arranged circumferentially.
10. A biochemical analyzer, comprising the biochemical photodetection system according to any one of claims 1 to 9.
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