CN215757354U - Gene detection equipment - Google Patents
Gene detection equipment Download PDFInfo
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- CN215757354U CN215757354U CN202120380269.2U CN202120380269U CN215757354U CN 215757354 U CN215757354 U CN 215757354U CN 202120380269 U CN202120380269 U CN 202120380269U CN 215757354 U CN215757354 U CN 215757354U
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Abstract
The application discloses gene detection equipment, including frame, switch drive arrangement, pressure differential drive arrangement, heating device, optical device and detection drive arrangement. The base is provided with a bearing position, and the bearing position is used for bearing the gene detection kit. The switch driving device is used for driving the flow channel switch of the gene detection kit to move. The pressure difference driving device is used for driving the sample and/or the reagent to flow in the flow channel of the gene detection kit through the pressure difference. The heating device is movably arranged on the machine base and can move close to and far away from the bearing position. The optical device is movably arranged on the base and can move close to and away from the bearing position, the optical device is used for photographing nucleic acid in the container, and the detection driving device is used for driving the heating device and the optical device to move on the base. Due to the addition of the heating device and the optical device, mechanical support is provided for automation of heating processing and detection image acquisition.
Description
Technical Field
The application relates to the technical field of biological detection equipment, in particular to gene detection equipment.
Background
In practice of gene detection on samples, the prior art mostly adopts step-by-step operation, which separates the steps of gene extraction, treatment, detection and the like, and each step is operated by manual or semi-automatic equipment. However, the step-by-step manual operation has low efficiency, high error rate and large consumption of human resources. Therefore, an integrated and automated gene assaying device is a research and development direction, and in order to develop an integrated and automated gene assaying device, it is necessary to automate the heating process and the detection image acquisition.
SUMMERY OF THE UTILITY MODEL
The utility model mainly solves the technical problems that: how to provide mechanical structural support for the automation of the heating process and the acquisition of the inspection image.
In a first aspect, an embodiment provides a genetic testing device comprising:
the base is provided with a bearing position, and the bearing position is used for bearing a gene detection kit;
the switch driving device is used for driving a runner switch of the gene detection kit to move so as to realize the communication and the sealing of a runner in the gene detection kit;
the differential pressure driving device is used for driving the sample and/or the reagent to flow in the flow channel of the gene detection kit through differential pressure so that the sample and the reagent in the gene detection kit can react in sequence according to the experimental steps, the nucleic acid of the sample is extracted, and the nucleic acid is driven to be transferred into the container for amplification;
the heating device is movably arranged on the machine base, can move close to and far away from the bearing position, and is used for providing a heating environment for the bearing position;
the optical device is movably arranged on the base and can move close to and away from the bearing position, and the optical device is used for photographing the nucleic acid in the container; and
and the detection driving device is used for driving the heating device and the optical device to move on the base.
In one embodiment, the detection driving device is used for driving the heating device and the optical device to move respectively, or used for driving the heating device and the optical device to move simultaneously.
In one embodiment, the detection driving device comprises a driving motor, a sliding rail, a driving belt wheel, a driven belt wheel, a synchronous belt and a mounting piece;
the slide rail sets up on the frame, optical device and slide rail sliding connection, the installed part is parallel with the slide rail, the installed part is connected with the frame, driving motor sets up on the installed part, driving motor's output is connected with driving pulley, the hold-in range cup joints with driving pulley and driven pulley, optical device is connected with the hold-in range, heating device is connected with optical device, driving device is used for driving pulley to rotate, and then drives optical device and heating device and move on the slide rail.
In one embodiment, the heating device comprises a heat source, a fan and a ventilation pipeline, wherein one end of the ventilation pipeline is used for facing to the bearing position, the heat source and the fan are connected with the ventilation pipeline, the heat source is used for generating heat to heat air, and the fan is used for conveying the hot air to the bearing position through the ventilation pipeline.
In one embodiment, the optical device comprises a light source and a filter, the filter is arranged on one side of the light source, light emitted by the light source passes through the filter, and the light source is used for irradiating the container loaded with nucleic acid on the bearing position.
In one embodiment, the optical device comprises a camera assembly for taking a picture of the nucleic acid loaded container on the carrier site.
In one embodiment, the temperature control device further comprises a temperature controller, the temperature controller is connected with the base and located on one side of the bearing position, and the temperature controller is used for monitoring the ambient temperature of the bearing position.
In one embodiment, the base comprises a bottom plate and a shell, the shell is arranged on the bottom plate, the bearing position is connected with the inner wall of the shell, a consumable warehouse inlet is formed in the shell and communicated with the bearing position, and the heating device and the optical device are movably arranged on the bottom plate.
In one embodiment, the differential pressure driving device comprises a vacuum pump and a connecting pipeline, wherein one end of the connecting pipeline is connected with the vacuum pump, and the other end of the connecting pipeline is used for being connected with the gene detection kit.
In one embodiment, the switch driving device comprises a linear motor and a screw rod, wherein the output end of the linear motor is connected with the screw rod, and the linear motor is used for driving the screw rod to move along the extension direction of the screw rod so as to drive the runner switch of the gene detection kit to move through the screw rod.
The gene detection device according to the embodiment comprises a machine base, a switch driving device, a pressure difference driving device, a heating device, an optical device and a detection driving device. The base is provided with a bearing position, and the bearing position is used for bearing the gene detection kit. The switch driving device is used for driving the flow channel switch of the gene detection kit to move so as to realize the communication and the sealing of the flow channel in the gene detection kit. The pressure difference driving device is used for driving the sample and/or the reagent to flow in the flow channel of the gene detection kit through pressure difference, so that the sample and the reagent in the gene detection kit can react in sequence according to the experimental steps, the nucleic acid of the sample is extracted, and the nucleic acid is driven to be transferred into the container for amplification. The heating device is movably arranged on the machine base, can move close to and far away from the bearing position, and is used for providing a heating environment for the bearing position. The optical device is movably arranged on the base and can move close to and away from the bearing position, the optical device is used for photographing nucleic acid in the container, and the detection driving device is used for driving the heating device and the optical device to move on the base. Due to the addition of the heating device and the optical device, mechanical support is provided for automation of heating processing and detection image acquisition. When a heating environment is required to be provided for the bearing position, the heating device is driven to move close to the bearing position by the detection driving device, when the environment temperature of the bearing position is improved by the heating device, when nucleic acid in a container on the bearing position is required to be photographed, the optical device is driven to move close to the bearing position by the detection driving device, and the nucleic acid in the container is photographed by the optical device.
Drawings
FIG. 1 is a schematic view showing the structure of a gene assaying device according to an embodiment of the present application;
FIG. 2 is a schematic view showing the internal structure of a gene assaying device according to an embodiment of the present application;
FIG. 3 is a schematic view of the internal structure of the genetic testing device and the camera bellows at a viewing angle according to an embodiment of the present disclosure;
FIG. 4 is a schematic view of the internal structure of the genetic testing device and the camera bellows at another viewing angle according to an embodiment of the present disclosure.
Reference numerals: 100. a machine base; 110. a base plate; 120. a housing; 121. feeding consumables into a bin port; 122. a display screen; 130. a bearing position; 200. a switch drive device; 210. a linear motor; 300. a heating device; 310. A fan; 320. a ventilation duct; 400. an optical device; 410. a light source; 420. an optical filter; 430. a camera assembly; 440. a camera dark box; 500. detecting a driving device; 510. a drive motor; 520. a slide rail; 530. A driving pulley; 540. a driven pulley; 550. a synchronous belt; 560. a mounting member; 600. a gene detection kit; 700. and (7) a temperature controller.
Detailed Description
The present invention will be described in further detail with reference to the following detailed description and accompanying drawings. Wherein like elements in different embodiments are numbered with like associated elements. In the following description, numerous details are set forth in order to provide a better understanding of the present application. However, those skilled in the art will readily recognize that some of the features may be omitted or replaced with other elements, materials, methods in different instances. In some instances, certain operations related to the present application have not been shown or described in detail in order to avoid obscuring the core of the present application from excessive description, and it is not necessary for those skilled in the art to describe these operations in detail, so that they may be fully understood from the description in the specification and the general knowledge in the art.
Furthermore, the features, operations, or characteristics described in the specification may be combined in any suitable manner to form various embodiments. Also, the various steps or actions in the method descriptions may be transposed or transposed in order, as will be apparent to one of ordinary skill in the art. Thus, the various sequences in the specification and drawings are for the purpose of describing certain embodiments only and are not intended to imply a required sequence unless otherwise indicated where such sequence must be followed.
The numbering of the components as such, e.g., "first", "second", etc., is used herein only to distinguish the objects as described, and does not have any sequential or technical meaning. The term "connected" and "coupled" when used in this application, unless otherwise indicated, includes both direct and indirect connections (couplings).
The present embodiment provides a gene assaying device.
Referring to fig. 1-4, the gene testing apparatus includes a base 100, a switch driving device 200, a differential pressure driving device (not shown), a heating device 300, an optical device 400, and a testing driving device 500.
The machine base 100 is provided with a bearing position 130, and the bearing position 130 is used for bearing the gene detection kit 600. The switch driving device 200 is used for driving the flow channel switch of the gene detection kit 600 to move, so as to realize the communication and the sealing of the flow channel in the gene detection kit 600. The pressure difference driving device is used for driving the sample and/or the reagent to flow in the flow channel of the gene detection kit 600 through the pressure difference, so that the sample and the reagent in the gene detection kit 600 can react in sequence according to the experimental steps, the nucleic acid of the sample is extracted, and the nucleic acid is driven to be transferred to the container for amplification. The heating device 300 is movably disposed on the machine base 100, the heating device 300 can move close to and away from the carrying position 130, and the heating device 300 is used for providing a heating environment for the carrying position 130. The optical device 400 is movably disposed on the base 100, the optical device 400 can move close to and away from the loading position 130, the optical device 400 is used for photographing the nucleic acid in the container, and the detection driving device 500 is used for driving the heating device 300 and the optical device 400 to move on the base 100.
Due to the addition of the heating device 300 and the optical device 400, mechanical support is provided for automation of the heating process and acquisition of the inspection image. When a heating environment needs to be provided for the carrying position 130, the detection driving device 500 drives the heating device 300 to move close to the carrying position 130, the heating device 300 increases the environment temperature of the carrying position 130, and when the nucleic acid in the container on the carrying position 130 needs to be photographed, the detection driving device 500 drives the optical device 400 to move close to the carrying position 130, and the nucleic acid in the container is photographed through the optical device 400. Specifically, in this embodiment, the container for loading nucleic acid is a PCR tube, and in other embodiments, the container may be other suitable tubes.
It should be noted that the description of the gene assaying kit 600 is introduced herein only for the convenience of understanding the operation principle of the gene assaying device, and does not mean that the gene assaying kit 600 is necessarily a component of the gene assaying device. That is, in one embodiment, the gene assaying kit 600 may be a component of the gene assaying device, and in another embodiment, the gene assaying kit 600 is not a component of the gene assaying device but a consumable of the gene assaying device.
Referring to fig. 2-4, in one embodiment, the detection driving device 500 is used to drive the heating device 300 and the optical device 400 to move separately or drive the heating device 300 and the optical device 400 to move simultaneously.
In this embodiment, the detection driving device 500 drives the heating device 300 and the optical device 400 to move simultaneously. In other embodiments, the detection driving device 500 may drive the heating device 300 and the optical device 400 to move respectively, for example, the detection driving device 500 includes two independent power sources, and the two power sources are connected to the heating device 300 and the optical device 400 in a one-to-one correspondence to drive the heating device 300 and the optical device 400 to move respectively. Specifically, the power source may be a motor, a cylinder, or the like.
Referring to fig. 2-4, in one embodiment, the detection driving device 500 includes a driving motor 510, a slide rail 520, a driving pulley 530, a driven pulley 540, a timing belt 550, and a mounting member 560.
When the optical device 400 and the heating device 300 need to be driven to move, the driving belt wheel 530 is driven to rotate by the driving motor 510, so as to drive the synchronous belt 550 to move, and further drive the optical device 400 and the heating device 300 to move on the sliding rail 520, so that the optical device 400 or the heating device 300 moves below the carrying position 130. Specifically, the bottom of the carrying position 130 has a through hole, and when the heating device 300 moves to a position below the carrying position 130, the air outlet of the ventilation duct 320 faces the through hole at the bottom of the carrying position 130. When the optical device 400 moves below the carrying location 130, the lens of the camera assembly 430 faces the through hole at the bottom of the carrying location 130.
Referring to fig. 2-4, in one embodiment, the heating device 300 includes a heat source (not shown), a fan 310, and an air duct 320, wherein one end of the air duct 320 is used to face the carrying location 130, the heat source and the fan 310 are connected to the air duct 320, the heat source is used to generate heat to heat air, and the fan 310 is used to deliver the hot air to the carrying location 130 through the air duct 320.
When it is necessary to increase the ambient temperature of the loading position 130, for example, when amplifying nucleic acids in the container, air is heated by the heat source, and the fan 310 delivers the heated air to the loading position 130 through the ventilation duct to increase the ambient temperature of the loading position 130. Specifically, the heat source can be a heating resistance wire or other suitable heating elements.
Referring to FIGS. 2-4, in one embodiment, the optical device 400 includes a light source 410 and a filter 420, the filter 420 is disposed on one side of the light source 410, the light emitted from the light source 410 passes through the filter 420, and the light source 410 is used to irradiate the container loaded with nucleic acid on the loading position 130. Light in accordance with the requirements of the experiment is emitted to the container holding the nucleic acid through the light source 410 and the filter 420.
Referring to FIGS. 2-4, in one embodiment, the optical device 400 includes a camera assembly 430, and the camera assembly 430 is used to photograph the container loaded with nucleic acid on the loading position 130. The nucleic acid in the container is photographed by the camera assembly 430. Specifically, the camera assembly 430 includes a camera body and a camera lens, and the camera lens is used to face the carrying position 130. The nucleic acids in the containers of the loading station 130 can be combined with a fluorescent reagent to enhance the image capture effect of the optical device 400.
Referring to fig. 2-4, in an embodiment, the optical apparatus 400 includes a photo-taking dark box 440, the light source 410, the optical filter 420 and the camera assembly 430 are disposed in the photo-taking dark box 440, and the photo-taking dark box 440 has an opening facing a side of the carrying position 130. The increase of the camera bellows 440 is beneficial to improving the image capturing effect of the optical device 400.
Referring to fig. 2-4, in an embodiment, the gene testing apparatus further includes a temperature controller 700, the temperature controller 700 is connected to the base 100, the temperature controller 700 is located at one side of the carrying position 130, and the temperature controller 700 is used for monitoring the ambient temperature of the carrying position 130. The temperature controller 700 detects the ambient temperature of the bearing position 130, which is beneficial to further realizing the accurate control of the experiment temperature.
Referring to fig. 1-4, in an embodiment, the base 100 includes a base plate 110 and a housing 120, the housing 120 is disposed on the base plate 110, the carrying position 130 is connected to an inner wall of the housing 120, the housing 120 is provided with a consumable inlet 121, the consumable inlet 121 is communicated with the carrying position 130, and the heating device 300 and the optical device 400 are movably disposed on the base plate 110. When performing gene testing, the gene testing kit 600 is put into the loading position 130 in the housing 120 from the consumable material loading opening 121.
Referring to fig. 1, in one embodiment, a display screen 122 is disposed on the housing 120.
In one embodiment, the differential pressure driving apparatus includes a vacuum pump and a connection pipe, one end of the connection pipe is connected to the vacuum pump, and the other end is used for connecting to the gene assaying kit 600. The driving of the sample and the reagent in the gene detection kit 600 is realized by making an air pressure difference by a vacuum pump.
Referring to fig. 2-4, in an embodiment, the switch driving device 200 includes a linear motor 210 and a screw (not shown), an output end of the linear motor 210 is connected to the screw, and the linear motor 210 is used for driving the screw to move along an extending direction thereof, so as to drive the flow channel switch of the gene detection kit 600 to move through the screw.
When the flow channel switch on the gene detection kit 600 needs to be driven to move, the linear motor 210 drives the screw rod to move, and then the screw rod drives the flow channel switch of the gene detection kit 600 to move, so that the communication and the sealing of the flow channel in the gene detection kit 600 are realized.
The present invention has been described in terms of specific examples, which are provided to aid understanding of the utility model and are not intended to be limiting. For a person skilled in the art to which the utility model pertains, several simple deductions, modifications or substitutions may be made according to the idea of the utility model.
Claims (10)
1. A gene assaying device characterized by comprising:
the base is provided with a bearing position, and the bearing position is used for bearing a gene detection kit;
the switch driving device is used for driving a runner switch of the gene detection kit to move so as to realize the communication and the sealing of a runner in the gene detection kit;
the differential pressure driving device is used for driving the sample and/or the reagent to flow in the flow channel of the gene detection kit through differential pressure so that the sample and the reagent in the gene detection kit can react in sequence according to the experimental steps, the nucleic acid of the sample is extracted, and the nucleic acid is driven to be transferred into the container for amplification;
the heating device is movably arranged on the machine base, can move close to and far away from the bearing position, and is used for providing a heating environment for the bearing position;
the optical device is movably arranged on the base and can move close to and away from the bearing position, and the optical device is used for photographing the nucleic acid in the container; and
and the detection driving device is used for driving the heating device and the optical device to move on the base.
2. The gene assaying device according to claim 1, wherein the detection driving means is for driving the heating means and the optical means to move separately or for driving the heating means and the optical means to move simultaneously.
3. The gene assaying device according to claim 2, wherein the detection driving means comprises a driving motor, a slide rail, a driving pulley, a driven pulley, a timing belt, and a mounting member;
the slide rail sets up on the frame, optical device and slide rail sliding connection, the installed part is parallel with the slide rail, the installed part is connected with the frame, driving motor sets up on the installed part, driving motor's output is connected with driving pulley, the hold-in range cup joints with driving pulley and driven pulley, optical device is connected with the hold-in range, heating device is connected with optical device, driving device is used for driving pulley to rotate, and then drives optical device and heating device and move on the slide rail.
4. The gene detection device of claim 1, wherein the heating device comprises a heat source, a fan and a ventilation duct, one end of the ventilation duct is used for facing the bearing position, the heat source and the fan are connected with the ventilation duct, the heat source is used for generating heat to heat air, and the fan is used for conveying hot air to the bearing position through the ventilation duct.
5. The gene assaying device according to claim 1, wherein the optical means comprises a light source and a filter, the filter being disposed on one side of the light source, the light emitted from the light source passing through the filter, and the light source being used to irradiate the nucleic acid-loaded container on the carrying site.
6. The gene assaying device according to claim 1, wherein the optical means comprises a camera module for photographing the nucleic acid-loaded container on the carrying site.
7. The gene detecting apparatus of claim 1, further comprising a temperature controller, wherein the temperature controller is connected to the base, the temperature controller is located at one side of the carrying position, and the temperature controller is used for monitoring the ambient temperature of the carrying position.
8. The gene assaying device according to any one of claims 1 to 7, wherein the housing comprises a bottom plate and a housing, the housing is disposed on the bottom plate, the loading location is connected to an inner wall of the housing, the housing is provided with a consumable inlet, the consumable inlet is communicated with the loading location, and the heating device and the optical device are movably disposed on the bottom plate.
9. The gene assaying device according to any one of claims 1 to 7, wherein the differential pressure driving means comprises a vacuum pump and a connecting tube having one end connected to the vacuum pump and the other end for connecting to a gene assaying kit.
10. The gene detecting apparatus according to any one of claims 1 to 7, wherein the switch driving device comprises a linear motor and a screw rod, an output end of the linear motor is connected to the screw rod, and the linear motor is used for driving the screw rod to move along an extending direction thereof so as to drive the flow channel switch of the gene detecting kit to move through the screw rod.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202120380269.2U CN215757354U (en) | 2021-02-19 | 2021-02-19 | Gene detection equipment |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202120380269.2U CN215757354U (en) | 2021-02-19 | 2021-02-19 | Gene detection equipment |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN215757354U true CN215757354U (en) | 2022-02-08 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202120380269.2U Active CN215757354U (en) | 2021-02-19 | 2021-02-19 | Gene detection equipment |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN215757354U (en) |
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2021
- 2021-02-19 CN CN202120380269.2U patent/CN215757354U/en active Active
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