CN215692332U - Bio-pharmaceuticals extract filter equipment - Google Patents
Bio-pharmaceuticals extract filter equipment Download PDFInfo
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- CN215692332U CN215692332U CN202120165344.3U CN202120165344U CN215692332U CN 215692332 U CN215692332 U CN 215692332U CN 202120165344 U CN202120165344 U CN 202120165344U CN 215692332 U CN215692332 U CN 215692332U
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- Prior art keywords
- filter
- shell
- inner cavity
- pipeline
- filtering
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- 229960000074 biopharmaceutical Drugs 0.000 title claims abstract description 24
- 239000007788 liquid Substances 0.000 claims abstract description 49
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 44
- 239000000706 filtrate Substances 0.000 claims abstract description 17
- 238000003860 storage Methods 0.000 claims abstract description 17
- 239000002699 waste material Substances 0.000 claims abstract description 17
- 229920000742 Cotton Polymers 0.000 claims abstract description 15
- 239000007921 spray Substances 0.000 claims abstract description 8
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 11
- 230000001954 sterilising effect Effects 0.000 claims description 10
- 238000007789 sealing Methods 0.000 claims description 3
- 238000004659 sterilization and disinfection Methods 0.000 claims 2
- 238000001914 filtration Methods 0.000 abstract description 48
- 239000003814 drug Substances 0.000 description 6
- 239000010865 sewage Substances 0.000 description 6
- 244000005700 microbiome Species 0.000 description 5
- 229940079593 drug Drugs 0.000 description 3
- 230000005611 electricity Effects 0.000 description 3
- ULGZDMOVFRHVEP-RWJQBGPGSA-N Erythromycin Chemical compound O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)C(=O)[C@H](C)C[C@@](C)(O)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 ULGZDMOVFRHVEP-RWJQBGPGSA-N 0.000 description 2
- 239000003124 biologic agent Substances 0.000 description 2
- 238000004140 cleaning Methods 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
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- 238000004321 preservation Methods 0.000 description 2
- 230000009261 transgenic effect Effects 0.000 description 2
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- 101710081722 Antitrypsin Proteins 0.000 description 1
- 241000283690 Bos taurus Species 0.000 description 1
- 206010058314 Dysplasia Diseases 0.000 description 1
- CEAZRRDELHUEMR-URQXQFDESA-N Gentamicin Chemical compound O1[C@H](C(C)NC)CC[C@@H](N)[C@H]1O[C@H]1[C@H](O)[C@@H](O[C@@H]2[C@@H]([C@@H](NC)[C@@](C)(O)CO2)O)[C@H](N)C[C@@H]1N CEAZRRDELHUEMR-URQXQFDESA-N 0.000 description 1
- 229930182566 Gentamicin Natural products 0.000 description 1
- OJMMVQQUTAEWLP-UHFFFAOYSA-N Lincomycin Natural products CN1CC(CCC)CC1C(=O)NC(C(C)O)C1C(O)C(O)C(O)C(SC)O1 OJMMVQQUTAEWLP-UHFFFAOYSA-N 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
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- 235000005824 Zea mays ssp. parviglumis Nutrition 0.000 description 1
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- 229940088710 antibiotic agent Drugs 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 201000011510 cancer Diseases 0.000 description 1
- 229910052799 carbon Inorganic materials 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 238000005253 cladding Methods 0.000 description 1
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- 208000029078 coronary artery disease Diseases 0.000 description 1
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- 239000012535 impurity Substances 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- OJMMVQQUTAEWLP-KIDUDLJLSA-N lincomycin Chemical compound CN1C[C@H](CCC)C[C@H]1C(=O)N[C@H]([C@@H](C)O)[C@@H]1[C@H](O)[C@H](O)[C@@H](O)[C@@H](SC)O1 OJMMVQQUTAEWLP-KIDUDLJLSA-N 0.000 description 1
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- 229940088594 vitamin Drugs 0.000 description 1
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- 235000013343 vitamin Nutrition 0.000 description 1
- 150000003722 vitamin derivatives Chemical class 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
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- Water Treatment By Sorption (AREA)
Abstract
The utility model relates to a bio-pharmaceutical extract filtering device, which comprises a shell, a base, a bearing platform, a filtering barrel and an upper cover, wherein the inner cavity of the shell is filled with water, the base is positioned at the bottom of the shell, the bearing platform is positioned in the inner cavity of the shell, the filtering barrel is positioned above the bearing platform, the top of the filtering barrel is flush with the top of the shell, the upper cover is positioned at the top of the shell, the inner cavity of the filtering barrel is sequentially provided with a coarse filtering plate, a fine filtering plate, filtering cotton and a microporous filtering plate from top to bottom, one side of the bottom of the filtering barrel is communicated with a filtrate storage tank positioned at the bottom of the inner cavity of the shell through a first pipeline, the other side of the bottom of the filtering barrel is communicated with a waste liquid treatment mechanism positioned at one side of the top of the base through a second pipeline, one side of the bottom of the inner cavity of the shell is provided with an electric heater, the outer side wall of the shell is provided with a water pump, the water pump is connected with a spray head through a third pipeline, and is communicated with a water taking port on the inner side wall of the shell through a fourth pipeline, the utility model can be suitable for low-temperature environment and can effectively treat the generated waste liquid.
Description
Technical Field
The utility model relates to a filtering device for a biopharmaceutical extracting solution, and belongs to the field of biopharmaceutical processing equipment.
Background
The biological pharmacy is a method for producing medicines by using a biological living body, for example, a human antibody is produced by using transgenic corn, antitrypsin is expressed by transgenic bovine mammary gland, the prospect of the biological pharmacy industry is wide, half of the medicines in the world are biosynthesized, the medicines can be widely used for treating various diseases such as cancer, AIDS, coronary heart disease, anemia, dysplasia, diabetes and the like, most of the antibiotics which are applied in the medicine are from microorganisms such as vitamin, erythromycin, lincomycin and gentamycin for injection.
In the biopharmaceutical process, the biopharmaceutical extract is required to be filtered, however, the prior biopharmaceutical extract filtering device has the following typical problems: firstly, it is not guaranteed that the biopharmaceutical extract is filtered at a suitable temperature. Because the biological agent has higher temperature requirement than common agents, the activity of the biological agent can be influenced when the temperature is too low, and even the filtrate can be frozen, the important significance is realized in ensuring that the filtering operation is carried out at the proper temperature; in addition, the prior bio-pharmaceutical extract filtering device does not consider the treatment of waste liquid, the washing waste liquid after the operation is generally directly discharged, and the biological medicament can cause serious influence on the environment without being treated. Therefore, it is of great significance to design a novel bio-pharmaceutical extract filtering device to solve the existing problems.
SUMMERY OF THE UTILITY MODEL
The utility model aims to provide a bio-pharmaceutical extract filtering device, which solves the problems that the existing bio-pharmaceutical extract filtering device has poor adaptability to environmental temperature and is inconvenient to use in cold regions and production waste liquid cannot be effectively treated.
In order to solve the problems existing in the technical background, the utility model provides the following technical scheme:
a bio-pharmaceutical extract filtering device comprises a shell, a base, a bearing platform, a filtering barrel and an upper cover, wherein the inner cavity of the shell is filled with water, the base is positioned at the bottom of the shell, the bearing platform is positioned in the inner cavity of the shell, the filtering barrel is positioned above the bearing platform, the top of the filtering barrel is flush with the top of the shell, the upper cover is positioned at the top of the shell, the inner cavity of the filtering barrel is sequentially provided with a coarse filtering plate, a fine filtering plate, filtering cotton and a microporous filtering plate from top to bottom, one side of the bottom of the filtering barrel is communicated with a filtrate storage tank positioned at the bottom of the inner cavity of the shell through a first pipeline, the other side of the bottom of the filtering barrel is communicated with a waste liquid treatment mechanism positioned at one side of the top of the base through a second pipeline, one side of the bottom of the inner cavity of the shell is provided with an electric heater, the outer side wall of the shell is provided with a water pump, the water pump is connected with a spray nozzle through a third pipeline, and the water inlet on the inner side wall of the shell through a fourth pipeline, the water pump top is equipped with the pipeline containing box, base top opposite side is equipped with the PLC controller, electric heater, water pump all with the PLC controller electricity is connected.
Preferably, the casing outside cladding has the heat preservation, the cushion cap is the perforated plate, upper cover inner chamber parcel has heat preservation sealing rubber, there is the pull ring upper cover top.
Preferably, plugs are arranged at two ends of the rough filtering plate, the plugs are matched with slots above the inner cavity of the filtering barrel, and the slots are internally connected with limiting plates through springs; the micropore filter plate is arranged on a mounting seat of an inner cavity of the filter barrel, the filter cotton is arranged on the micropore filter plate, and the fine filter plate is arranged on the filter cotton.
Preferably, the diameters of the filter holes of the coarse filter plate, the fine filter plate, the filter cotton and the microporous filter plate are gradually reduced.
Preferably, the waste liquid treatment mechanism includes the box, box inner chamber top is equipped with the ultraviolet sterilizing lamp, box inner chamber top is equipped with the filter chamber, the filter chamber intussuseption is filled with active carbon, box inner chamber lateral wall is equipped with the level gauge, the bottom half is equipped with the fluid-discharge tube and has manual valve on a fluid-discharge tube, the ultraviolet sterilizing lamp with the level gauge all is connected with the PLC controller electricity.
Preferably, the first pipeline and the second pipeline are respectively provided with a first electric valve and a second electric valve, the bottom of the filtrate storage tank is provided with a second liquid discharge pipe, the second liquid discharge pipe penetrates through the bottom of the shell and the base, and the tail end of the second liquid discharge pipe is provided with a manual valve.
The utility model has the beneficial effects that: when the water-saving filter is used in a low-temperature environment, the PLC controller is used for starting the electric heater to heat water in the inner cavity of the shell to a proper temperature, and the water bath heats the filter barrel, so that the filtering operation in the filter barrel can be carried out at the proper temperature; pour the bio-pharmaceuticals extract into the filter vat in, the bio-pharmaceuticals extract is through the thick filter plate that the filtration pore reduces gradually in proper order, the thin filter plate, cross the filter pulp, can obtain limpid filtrating behind the micropore filter plate, open through PLC controller control electric valve one, the filtrating flows into the filtrating storage jar after pipeline one and stores, because the filtrating storage jar is also in the water bath of casing inner chamber, so filtrating can store under suitable temperature, can guarantee that the filtrating in the filtrating storage jar has fine activity, only need open the manual valve on filtrating storage jar bottom fluid-discharge tube two and can take out filtrating when needs get rid of the filtrating.
After the filtering operation is completed, the PLC controller closes the first electric valve and opens the second electric valve and the water pump, the water pump takes water from the inner cavity of the shell through the water intake of the inner cavity of the shell, the fourth pipeline takes water from the inner cavity of the shell, the water sequentially enters the third pipeline and the spray head, the filter barrel can be cleaned through the spray head, the cleaned sewage flows into the waste liquid treatment mechanism through the second pipeline, the ultraviolet sterilizing lamp can kill microorganisms in the cleaning liquid after entering the waste liquid treatment mechanism, the microorganisms in the sewage after passing through the filter chamber can be further adsorbed by activated carbon, the sewage is purified into harmless clear liquid after passing through the filter chamber and is stored below the box body, the clear liquid can be discharged through the liquid discharge pipe and added into the inner cavity of the shell again, and the clean liquid can be directly discharged into the environment without causing harm to the environment.
Drawings
The accompanying drawings, which are included to provide a further understanding of the utility model and are incorporated in and constitute a part of this specification, illustrate embodiments of the utility model and together with the description serve to explain the principles of the utility model and not to limit the utility model.
FIG. 1 is a schematic structural diagram of a main body of a biopharmaceutical extract filtering device of the present invention;
FIG. 2 is an enlarged view of a portion of a biopharmaceutical extract filtering device "A" of the present invention;
FIG. 3 is an enlarged view of a portion of a biopharmaceutical extract filtering device "B" of the present invention;
FIG. 4 is a schematic view of a waste liquid treatment mechanism of a biopharmaceutical extract filtering device of the present invention.
Reference numbers in the figures: 1. a housing; 2. a base; 3. a bearing platform; 4. a filter vat; 401. coarse filter plate; 4011. a plug; 402. fine filter plates; 403. filtering cotton; 404. a microporous filter plate; 405. A slot; 406. a spring; 407. a limiting plate; 408. a mounting seat; 5. an upper cover; 6. a first pipeline; 7. a filtrate storage tank; 8. a second pipeline; 9. a waste liquid treatment mechanism; 901. a box body; 902. an ultraviolet sterilizing lamp; 903. a filtering chamber; 904. activated carbon; 905. a liquid level meter; 906. a first liquid discharge pipe; 10. an electric heater; 11. a water pump; 12. a third pipeline; 13. a spray head, 14 and a pipeline IV; 15. a water intake; 16. a storage box; 17. a PLC controller; 18. a first electric valve; 19. an electric valve II; 20. and a second liquid discharge pipe.
Detailed Description
The present invention will be further described with reference to the following detailed description, wherein the drawings are for illustrative purposes only and are not intended to be limiting, wherein certain elements may be omitted, enlarged or reduced in size, and are not intended to represent the actual dimensions of the product, so as to better illustrate the detailed description of the utility model.
As shown in figures 1-4, a filtering device for bio-pharmaceutical extract comprises a shell 1, a base 2, a bearing platform 3, a filter barrel 4 and an upper cover 5, wherein the inner cavity of the shell 1 is filled with water, the base 2 is arranged at the bottom of the shell 1, the bearing platform 3 is arranged in the inner cavity of the shell 1, the filter barrel 4 is arranged above the bearing platform 3, the filter barrel 4 can be fixed on the bearing platform 3 (for example, fixed by bolts), the top of the filter barrel 4 is flush with the top of the shell 1, the upper cover 5 is arranged at the top of the shell 1, the inner cavity of the filter barrel 4 is sequentially provided with a coarse filter plate 401, a fine filter plate 402, filter cotton 403 and a microporous filter plate 404 from top to bottom, one side of the bottom of the filter barrel 4 is communicated with a filtrate storage tank 7 at the bottom of the inner cavity of the shell through a first pipeline 6, the other side of the bottom of the filter barrel 4 is communicated with a waste liquid treatment mechanism 9 at one side of the top of the base 2 through a second pipeline 8, one side of the bottom of the inner cavity of the shell 1 is provided with an electric heater 10, be equipped with water pump 11 on the 1 lateral wall of casing, water pump 11 passes through pipeline three 12 and connects shower nozzle 13, and water pump 11 passes through pipeline four 14 and communicates intake 15 on the casing inside wall, and water pump 11 top is equipped with pipeline containing box 16, and 2 top opposite sides of base are equipped with PLC controller 17, and electric heater 10, water pump 11 all connect the commercial power, and all with PLC controller 17 electricity is connected.
The outer side of the shell 1 is coated with a heat-insulating layer which can prevent the temperature of the water bath from dissipating, the bearing platform 3 is a porous plate, the design can ensure that the upper part and the lower part of the bearing platform 3 are communicated with water, the inner cavity of the upper cover 5 is coated with heat-insulating sealing rubber, and the top of the upper cover 5 is provided with a pull ring; plugs 4011 are arranged at two ends of the coarse filter plate 401, the plugs 4011 are matched with slots 405 above the inner cavity of the filter barrel 4, and the slots 405 are connected with limiting plates 407 through springs 406, so that the coarse filter plate can be flexibly detached in the filter barrel 4; the microporous filter plate 404 is arranged on a mounting seat 408 in the inner cavity of the filter barrel 4, the filter cotton 403 is arranged on the microporous filter plate 404, and the fine filter plate 402 is arranged on the filter cotton 403; the diameters of the filtering holes of the coarse filtering plate 401, the fine filtering plate 402, the filtering cotton 403 and the microporous filtering plate 404 are gradually reduced, and the design can ensure that the medicament is filtered by four stages to obtain clear liquid without impurities; the waste liquid treatment mechanism 9 comprises a box body 901, an ultraviolet sterilizing lamp 902 is arranged at the top of the inner cavity of the box body 901, a filter chamber 903 is arranged above the inner cavity of the box body 901, activated carbon 904 is filled in the filter chamber 903, a liquid level meter 905 is arranged on the side wall of the inner cavity of the box body 901, a first liquid discharge pipe 906 is arranged at the bottom of the box body 901, a manual valve is arranged on the first liquid discharge pipe 906, the ultraviolet sterilizing lamp 902 and the liquid level meter 905 are both electrically connected with a PLC (programmable logic controller) 17, and the PLC can control the opening of the ultraviolet sterilizing lamp 902 and the liquid level meter 905; the first pipeline 6 and the second pipeline 8 are respectively provided with a first electric valve 18 and a second electric valve 19, the bottom of the filtrate storage tank 7 is provided with a second liquid discharge pipe 20, the second liquid discharge pipe 20 penetrates through the bottom of the shell 1 and the base 2, and the tail end of the second liquid discharge pipe 20 is provided with a manual valve.
The specific working principle is as follows: when the utility model is used in a low-temperature environment, the PLC 17 is used for starting the electric heater to heat the water in the inner cavity of the shell to a proper temperature, and the water bath heats the filter barrel 4 at the moment, so that the filtering operation in the filter barrel 4 can be ensured to be carried out at the proper temperature; pouring the biopharmaceutical extract into the filter vat 4, obtaining clear filtrate after the biopharmaceutical extract sequentially passes through the coarse filter plate 401, the fine filter plate 402, the filter cotton 403 and the microporous filter plate 404 with gradually reduced filter holes, controlling the opening of the first electric valve 18 through the PLC 17, and allowing the filtrate to flow into the filtrate storage tank 7 for storage after passing through the first pipeline 6, wherein the filtrate storage tank 7 is also in a water bath in the inner cavity of the shell 1, so the filtrate can be stored at an appropriate temperature, and when the filtrate needs to be removed, the filtrate can be taken out only by opening a manual valve on a second liquid discharge pipe 20 at the bottom of the filtrate storage tank 7.
After the filtering operation is finished, the PLC controller closes the first electric valve 18, the second electric valve 19 and the water pump 11 are opened, the water pump 11 takes water from the inner cavity of the shell 1 through the water taking port 15 and the pipeline four 14 in the inner cavity of the shell 1, the water sequentially enters the pipeline three 12 and the spray head 13, the filter barrel 4 can be cleaned through the spray head 13, the cleaned sewage flows into the waste liquid treatment mechanism 9 through the pipeline two 8, the ultraviolet sterilizing lamp 902 can kill microorganisms in cleaning liquid after entering the waste liquid treatment mechanism 9, the microorganisms in the sewage after passing through the filter chamber 903 can be further adsorbed by the activated carbon 904, the sewage is purified into harmless clear liquid after passing through the filter chamber 903 and is stored below the box 901, and the clear liquid can be discharged through the first liquid discharge pipe 906 to be added into the inner cavity of the shell again and can also be directly discharged into the environment.
While there have been shown and described what are at present considered the preferred embodiments of the utility model, the fundamental principles and essential features of the utility model and advantages thereof, it will be understood by those skilled in the art that the utility model is not limited by the embodiments described above, which are included to illustrate the principles of the utility model, but that various changes and modifications may be made therein without departing from the spirit and scope of the utility model as defined by the appended claims and their equivalents.
Claims (6)
1. The utility model provides a bio-pharmaceuticals extract filter equipment, includes casing (1), base (2), cushion cap (3), filter vat (4), upper cover (5), casing (1) inner chamber is filled water, base (2) are located casing (1) bottom, cushion cap (3) are located casing (1) inner chamber, filter vat (4) are located cushion cap (3) top and filter vat (4) top and casing (1) top parallel and level, upper cover (5) are located casing (1) top, its characterized in that: the filter drum is characterized in that an inner cavity of the filter drum (4) is sequentially provided with a coarse filter plate (401), a fine filter plate (402), filter cotton (403) and a microporous filter plate (404) from top to bottom, one side of the bottom of the filter drum (4) is communicated with a filtrate storage tank (7) positioned at the bottom of the inner cavity of the shell through a first pipeline (6), the other side of the bottom of the filter drum (4) is communicated with a waste liquid treatment mechanism (9) positioned at one side of the top of the base (2) through a second pipeline (8), one side of the bottom of the inner cavity of the shell (1) is provided with an electric heater (10), the outer side wall of the shell (1) is provided with a water pump (11), the water pump (11) is connected with a spray head (13) through a third pipeline (12), the water pump (11) is communicated with a water intake (15) on the inner side wall of the shell through a fourth pipeline (14), a pipeline containing box (16) is arranged above the water pump (11), the other side of the top of the base (2) is provided with a PLC controller (17), the electric heater (10) and the water pump (11) are electrically connected with the PLC (17).
2. The apparatus of claim 1, wherein the apparatus further comprises: the outer side of the shell (1) is coated with a heat-insulating layer, the bearing platform (3) is a porous plate, the inner cavity of the upper cover (5) is wrapped with heat-insulating sealing rubber, and the top of the upper cover (5) is provided with a pull ring.
3. The apparatus of claim 1, wherein the apparatus further comprises: plugs (4011) are arranged at two ends of the coarse filter plate (401), the plugs (4011) are matched with slots (405) above the inner cavity of the filter barrel (4), and the slots (405) are internally connected with limiting plates (407) through springs (406); the micropore filter plate (404) is arranged on a mounting seat (408) of the inner cavity of the filter barrel (4), the filter cotton (403) is arranged on the micropore filter plate (404), and the fine filter plate (402) is arranged on the filter cotton (403).
4. The apparatus of claim 1, wherein the apparatus further comprises: the diameters of the filter holes of the coarse filter plate (401), the fine filter plate (402), the filter cotton (403) and the micropore filter plate (404) are gradually reduced.
5. The apparatus of claim 1, wherein the apparatus further comprises: the waste liquid treatment mechanism (9) comprises a box body (901), an ultraviolet sterilization lamp (902) is arranged at the top of an inner cavity of the box body (901), a filter chamber (903) is arranged above the inner cavity of the box body (901), activated carbon (904) is filled in the filter chamber (903), a liquid level meter (905) is arranged on the side wall of the inner cavity of the box body (901), a first liquid discharge pipe (906) is arranged at the bottom of the box body (901), a manual valve is arranged on the first liquid discharge pipe (906), and the ultraviolet sterilization lamp (902) and the liquid level meter (905) are electrically connected with a PLC (17).
6. The apparatus of claim 1, wherein the apparatus further comprises: the first pipeline (6) and the second pipeline (8) are respectively provided with a first electric valve (18) and a second electric valve (19), the bottom of the filtrate storage tank (7) is provided with a second liquid discharge pipe (20), the second liquid discharge pipe (20) penetrates through the bottom of the shell (1) and the base (2), and the tail end of the second liquid discharge pipe (20) is provided with a manual valve.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
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CN202120165344.3U CN215692332U (en) | 2021-01-21 | 2021-01-21 | Bio-pharmaceuticals extract filter equipment |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN202120165344.3U CN215692332U (en) | 2021-01-21 | 2021-01-21 | Bio-pharmaceuticals extract filter equipment |
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Publication Number | Publication Date |
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CN215692332U true CN215692332U (en) | 2022-02-01 |
Family
ID=79986096
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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CN202120165344.3U Expired - Fee Related CN215692332U (en) | 2021-01-21 | 2021-01-21 | Bio-pharmaceuticals extract filter equipment |
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CN (1) | CN215692332U (en) |
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2021
- 2021-01-21 CN CN202120165344.3U patent/CN215692332U/en not_active Expired - Fee Related
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Granted publication date: 20220201 |