CN215651736U

CN215651736U - Fixing device for experimental animal in non-anesthesia state

Info

Publication number: CN215651736U
Application number: CN202122092459.7U
Authority: CN
Inventors: 韩蓓; 程悦; 李静; 石璐; 韩蕾
Original assignee: Xian Jiaotong University
Current assignee: Xian Jiaotong University
Priority date: 2021-08-31
Filing date: 2021-08-31
Publication date: 2022-01-28
Anticipated expiration: 2031-08-31

Abstract

The fixing device for the experimental animal in the non-anesthesia state is simple in structure, and can be used for fixing the animal in the non-anesthesia state quickly, safely and conveniently during experiment operation so as to be used for subsequent experiment processes of operation, measurement, recording and the like. Comprises a base and two fixing units; the base comprises a hollow box with an opening at the upper end and a lower bottom plate, and the fixing unit comprises an adjusting track and two limb fixing rings; the adjusting track is arranged in the empty box and comprises a sliding track, a track sliding assembly, a track fixing assembly and a track sliding adjusting rod; the sliding rail is fixed at a reserved position on the side wall of the empty box, the rail fixing assembly is fixed at a preset position of the sliding rail, and the upper end of the rail fixing assembly is fixedly connected with the four-limb fixing ring; track sliding assembly sliding connection is on the slip track, and lower extreme and track slide adjusting lever one end fixed connection, the solid fixed ring of upper end fixed connection four limbs leaves on the empty case lateral wall and predetermines the hole, and the free end of track slide adjusting lever is worn out and is predetermine the hole.

Description

Fixing device for experimental animal in non-anesthesia state

Technical Field

The utility model belongs to the field of animal experiment instruments, and particularly relates to a fixing device for an experimental animal in a non-anesthesia state.

Background

Experimental animal science is an important supporting condition and a foundation subject for the research and development of modern life science, and not only the research of human genome plans, gene structures and functional omics relates to animal experiments, but the development of almost all fields related to medicine can not leave high-quality animal experiments. At present, the variety of experimental animals is very large, and rodent experimental animals including rats, mice and guinea pigs are the most important experimental animals in all the subdivided fields of medicine. When a rodent experimental animal model (hereinafter, the rodent experimental animal model is described by taking an example in a unified way) is used, morphological related parameters need to be recorded, for example, the record of the visual change of the skin in the establishment of a skin related model, the establishment of a growth and development related model needs to dynamically measure the form and the like; for another example, tail vein blood sampling operation is performed, which often requires fixing the mouse to ensure the accuracy and precision of the experiment.

At present, there is no unified mouse operation flow, and there are two most common fixing methods, one is to bind the four limbs of the mouse directly with ropes, fix the mouse on a flat plate or other apparatus with a proper size, and obtain the required posture by adjusting the length of the ropes. And the other method is to anaesthetize the mice and then fix the mice. The mouse is flexible in action and sharp in teeth, experimental operation is carried out by using a non-anesthesia fixing method, at least three experiential experimenters are needed to cooperate, namely, one experimenter grasps the fixing head of the mouse by one hand, one foot of the experimenter is fixed by the other hand, the other experimenter cooperates with the rope to bind the fixed foot of the mouse, and then other feet of the mouse are bound in sequence, except that the rope and a flat plate or a fixed appliance are needed to be adjusted by the experimenter, so that the experimental requirement is met. The method has the disadvantages of complicated steps, certain requirements on the manipulation of experimenters, and the need of cooperation of multiple persons, and because the materials are used and obtained nearby and have no fixed standard, improper selection of appliances and ropes can occur, and the mouse is unnecessarily injured in the operation process. The advantages of the second method, although solving the drawbacks of the non-anesthetic fixation method, are also evident, firstly, the type and amount of anesthetic to be used need to be determined, which depends more on the experience of the operator; secondly, a certain time is required for the anesthetic to exert the effect, which increases the operation time; finally, each anesthetic has certain toxic and side effects, and mice have individual differences, and even under the condition of proper usage amount, the experimental result cannot be guaranteed not to be influenced by the usage of the anesthetic, so that experimental variables are increased invisibly, and the final experimental result can be influenced. Both of the current methods require experiential experientials and are not conducive to new-hand operation.

SUMMERY OF THE UTILITY MODEL

Aiming at the problems in the prior art, the utility model provides a fixing device for experimental animals in a non-anesthesia state, which is simple in structure, and can be used for directly fixing the animals in the non-anesthesia state into a posture state required by an experiment quickly, safely and conveniently during experiment operation so as to be used for subsequent experiment processes of operation, measurement, recording and the like.

The utility model is realized by the following technical scheme:

a fixing device for experimental animals in a non-anesthesia state comprises a base and two fixing units;

the base comprises a hollow box with an opening at the upper end and a lower bottom plate, and the lower bottom plate is provided with two parallel grooves in a penetrating way;

the fixing unit comprises an adjusting track and two limb fixing rings, and the limb fixing rings penetrate through the grooves;

the adjusting track is arranged in the empty box and comprises a sliding track, a track sliding assembly, a track fixing assembly and a track sliding adjusting rod; the sliding rail is fixed at a reserved position on the side wall of the empty box, the rail fixing assembly is fixed at a preset position of the sliding rail, and the upper end of the rail fixing assembly is fixedly connected with a four-limb fixing ring; track sliding assembly sliding connection is on the slip track, and lower extreme and track slide adjusting lever one end fixed connection, another four limbs of upper end fixed connection solid fixed ring leaves on the empty case lateral wall and predetermines the hole, and the free end of track slide adjusting lever is worn out and is predetermine the hole.

Preferably, the lower bottom plate adopts a transparent plate, support legs are arranged at two ends of the transparent plate, and a base gap is arranged between the lower bottom plate and the empty box and used for placing scale paper.

Preferably, the scale paper box further comprises a transparent upper cover plate, and a cover plate gap is formed in the upper cover plate and used for placing scale paper.

Preferably, one corner of the upper cover plate is connected with the lower bottom plate through a hinge.

Preferably, an iron sheet is arranged at the diagonal of one corner of the upper cover plate and the lower base plate which are connected through a hinge, and a magnet is arranged at the position of the base corresponding to the iron sheet.

Preferably, the limb fixing ring is an anti-slip elastic silica gel ring.

Preferably, the limb fixing ring is connected with the track sliding assembly through screws.

Preferably, the part of the rail sliding adjusting rod penetrating through the side wall of the empty box is provided with a screw rod which is in threaded fit with a preset hole in a threaded hole.

Compared with the prior art, the utility model has the following beneficial technical effects:

the utility model provides a fixing device for experimental animals in a non-anesthesia state, which comprises a sliding rail fixed at a reserved position of a base, wherein a rail fixing component is fixedly connected to the sliding rail and sleeved with a rail sliding component in sliding connection with the rail fixing component, two ends of the rail sliding component are respectively connected with a four-limb fixing ring for fixing four limbs of an experimental animal and a rail sliding adjusting rod for adjusting the position of the four-limb fixing ring, the four limbs of the experimental animal can be longitudinally contracted and expanded by fixing the four limbs of the experimental animal through a soft and elastic silica gel four-limb fixing ring, and the relative position of the four-limb fixing ring is adjusted by adjusting the rail sliding adjusting rod to drive the rail sliding component to move so as to adapt to the difference of individual sizes among the experimental animals and to different experimental requirements.

The utility model is an integrated fixing device, which can avoid the complicated material preparation work before the technical implementation, when the fixing device is used, according to the size of the experimental animal for experiment, the screw rod of the rail sliding adjusting rod is rotated to drive the two rail sliding components fixedly connected with the screw rod to slide, the distance between the four limb fixing rings respectively positioned on the rail sliding components and the rail fixing components is adjusted to adapt to the experimental animals with different sizes, only one experimenter is needed to fix a mouse with one hand, the thumb and the forefinger of the other hand prop open the elastic silica gel fixing ring, the middle finger and the ring finger fix one four limbs of the mouse into the ring, the thumb and the forefinger can be loosened to fix the limb, the rest three limbs are fixed by the same method, if the distance between the four limb fixing rings has certain deviation after the fixation, the rail sliding adjusting rod can be adjusted again until the experiment requirement is met, the investment of manpower and time cost is greatly reduced, and the whole fixing process is simple, rapid and safe to operate and wide in application range.

When the utility model is used, the mouse does not need to be anesthetized in advance, so that the pain of animals caused by anesthesia operation can be avoided; the mouse stress reaction can be easily caused by complicated light and shadow and noise environment caused by simultaneous operation of too many experimenters, and the mouse stress reaction can be finished by a single person without the assistance of other persons.

The device is simple, the surface structure is smooth, the high-temperature and high-pressure resistant material is easy to clean and disinfect the surface, the cleanliness of the operation process can be ensured, a milder operation environment is brought to animals, and the requirements of certain animal experiments needing to control the microbial variables can be met.

The specification of the reserved gap of the upper cover plate is the same as that of the reserved gap between the lower base plate of the base and the empty box of the base, whether the scale paper is inserted or not can be selected automatically according to the experimental requirements, and the specification comprises the position of the scale paper, the accuracy of the scale paper and the like; the design of removable scale paper enables to measure more directly perceived, and the production of unnecessary experimental variable and the adverse effect that brings are reduced in more simple and convenient operation, for example the anesthetic dose in current fixed technology changes, and various stress response that different operating personnel amazing experimental animals produced etc. guarantee the accuracy of experimental result.

Drawings

FIG. 1 is a schematic perspective view of an experimental animal fixing device according to the present invention;

FIG. 2 is a plan view of the experimental animal holding device of the present invention (viewed from the upper cover plate downward);

FIG. 3 is a bottom view (looking up from the base) of the experimental animal holding device of the present invention;

FIG. 4 is a left side view of the experimental animal holding device of the present invention;

FIG. 5 is a schematic view of a three-dimensional structure of a fixing ring for four limbs and a track of the fixing device for an experimental animal according to the present invention;

FIG. 6 is a top view of the fixing ring for four limbs and the rail of the fixing device for laboratory animals according to the present invention;

FIG. 7 is a left side view of the connection of the limb fixing ring and the rail of the experimental animal fixing device of the utility model.

In the figure: 1. a fixing device; 2. adjusting the track; 3. an upper cover plate 4 and a screw rod; 5. a magnet and an iron piece; 6. empty boxes; 7. a lower base plate; 8. a base void; 9. a hinge; 10. a cover plate void; 11. fixing rings for four limbs; 12. a sliding track; 13. a track slide assembly; 14. a rail slide adjusting rod; 15. a screw; 16. a non-slip mat; 17. a thread; 18. presetting a hole; 19. a rail securing assembly.

Detailed Description

The present invention will now be described in further detail with reference to the attached drawings, which are illustrative, but not limiting, of the present invention.

As shown in fig. 1 to 4, a fixing device for a non-anesthetized experimental animal comprises a base and two fixing units; the base comprises an empty box 6 with an opening at the upper end and a lower bottom plate 7, and the lower bottom plate 7 is provided with two parallel grooves in a penetrating way; the fixing unit comprises an adjusting track 2 and two limb fixing rings 11, and the limb fixing rings 11 penetrate through the grooves; the adjusting track 2 is arranged inside the empty box 6, as shown in fig. 3 and 5-7, the adjusting track 2 comprises a sliding track 12, a track sliding component 13, a track fixing component 19 and a track sliding adjusting rod 14, the sliding track 12 is fixed at a reserved position on the side wall of the empty box, the track fixing component 19 is fixed at a preset position of the sliding track 12, and the upper end of the track fixing component is fixedly connected with a four-limb fixing ring 11; the track sliding assembly 13 is connected to the sliding track 12 in a sliding mode, the lower end of the track sliding assembly is fixedly connected with one end of the track sliding adjusting rod 14, the upper end of the track sliding adjusting rod is fixedly connected with the other limb fixing ring 11, a preset hole 18 is reserved in the side wall of the empty box, and the free end of the track sliding adjusting rod 14 penetrates out of the preset hole 18.

Further, as shown in fig. 3, the preset positions of the rail fixing assemblies 19 of the two fixing units are overlapped in the longitudinal direction of the bottom of the empty box, and the positions of the rail sliding assemblies 13 of the two fixing units are overlapped in the longitudinal direction of the bottom of the empty box.

Further, as shown in fig. 3, the rail sliding adjusting rod 14 includes two vertical rods fixedly connected to the rail sliding assemblies 13 of the two fixing units, respectively, a cross rod connected to the two vertical rods, and a screw rod 4 penetrating through the middle of the cross rod and connected thereto.

The utility model provides a fixing device for experimental animals in a non-anesthesia state, which comprises a sliding rail 12 arranged at a reserved position of a base, a rail sliding component 13 in sliding connection with the sliding rail 12 is sleeved on the sliding rail 12, two ends of the rail sliding component 13 are respectively connected with a four-limb fixing ring 11 for fixing four limbs of the experimental animals and a rail sliding adjusting rod 14 for adjusting the position of the four-limb fixing ring 11, the four limbs of the experimental animals are fixed through the soft and elastic silica gel four-limb fixing ring 11, so that the bodies of the experimental animals can be contracted and extended in the longitudinal direction, and the relative positions of the four-limb fixing rings 11 are adjusted to adapt to the difference of the sizes of the experimental animals and different experimental requirements by adjusting the rail sliding adjusting rod 14 to drive the rail sliding component 13 to move.

The utility model is an integrated fixing device, which can avoid the complicated material preparation work before the technical implementation, greatly shortens the investment of manpower and time cost, when in use, two rail sliding components 13 fixedly connected with the rail sliding adjusting rod 14 can be driven to slide by rotating the screw rod 4 of the rail sliding adjusting rod 14 according to the size of an experimental animal for experiment, the distance between the four limb fixing rings 11 which are respectively arranged on the rail sliding components 13 and the rail fixing components 19 and used for fixing the experimental animal is adjusted to adapt to the experimental animals with different sizes, only one hand of an experimenter is needed to fix a mouse when in fixing, the thumb and the forefinger of the other hand prop open the elastic silica gel four limb fixing rings 11, the middle finger and the ring finger can fix one limb fixing ring 11 of the mouse by loosening the thumb and the forefinger, the other three limbs are fixed by the same method, and a certain deviation exists between the four limb fixing rings 11 after the fixing is completed, the rail sliding adjusting rod 14 can be adjusted again until the experimental requirements are met, the whole fixing process is simple to operate, and the application range is wide.

When the four-limb fixing device is used, two limbs of an experimental animal can be fixed in the two four-limb fixing rings 11 connected with the track fixing component 19, the track sliding adjusting rod 14 is adjusted according to the size of the experimental animal, the positions of the two four-limb fixing rings 11 connected with the track sliding component 13 are determined, the other two limbs of the experimental animal are fixed, the fixing is completed, the specific using sequence is determined according to the actual situation, and the flexibility is high.

Preferably, as shown in fig. 5, the rail sliding assembly 13 and the rail fixing assembly 19 are fixedly connected with the limb fixing ring 11 through screws 15, the rail sliding assembly 13 and the rail fixing assembly 19 are sleeved on the sliding rail 12, and the rail fixing assembly 19 is fixedly connected with the sliding rail 12 through screws.

Further, as shown in fig. 1, two ends of the lower plate 7 are provided with support legs, and a base gap 8 is arranged between the lower plate 7 and the empty box 6 for placing scale paper.

Further, as shown in fig. 1, the experimental animal fixing device further comprises a transparent upper cover plate 3, a cover plate gap 10 is formed in the middle of the upper cover plate 3 and used for placing scale paper, the upper cover plate 3 and the lower base plate 7 are transparent plates, the fixing condition of the experimental animal can be observed conveniently, and measured relevant parameters can be recorded.

The specification of the reserved gap of the upper cover plate 3 is the same as that of the reserved gap between the base lower bottom plate 7 and the base empty box 6, whether the scale paper is inserted or not can be automatically selected according to the experimental requirement, and the specification comprises the position of the scale paper, the accuracy of the scale paper and the like; the design of removable scale paper enables to measure more directly perceived, and the production of unnecessary experimental variable and the adverse effect that brings are reduced in more simple and convenient operation, for example the anesthetic dose in current fixed technology changes, and various stress response that different operating personnel amazing experimental animals produced etc. guarantee the accuracy of experimental result.

Preferably, the length and width of the reserved gap are 15cm and 12cm, respectively.

Further, as shown in fig. 1 and 2, one corner of the upper cover plate 3 is connected to the lower plate 7 by a hinge 9.

Further, as shown in fig. 1 and 2, an iron sheet is arranged at the diagonal of one corner of the upper cover plate 3 and the lower base plate 7 which are connected by a hinge, and a magnet is arranged at the position of the base corresponding to the iron sheet.

One end of an upper cover plate 3 is connected with a lower base plate 7 of the base through a metal hinge 9, so that a transparent plate at the upper part can be turned over by 180 degrees up and down, and the transparent plate can be fixed through the attraction of a metal sheet which is pasted diagonally and a strong magnet which is fixed at the corresponding part of the base.

Furthermore, the limb fixing ring 11 is an anti-slip elastic silica gel ring, and the utility model adopts soft and elastic fixing materials, so that the pain of binding and fixing the experimental animals can be reduced, and unnecessary injury to the animals caused by scratching the experimental animals by coarse and thin ropes, wires, belts and the like of the fixing materials can be avoided.

Further, as shown in fig. 3, a screw rod 4 is arranged at one end of the rail sliding adjusting rod 14, which penetrates through the side wall of the empty box 6, and is in threaded fit with a preset hole 18 which is arranged in a threaded hole; the track sliding adjusting rod 14 penetrates out of the preset hole 18 in the side wall of the empty box 6, and the screw rods 4 are arranged in the space from the inside and the outside of the empty box 6 to the outside, so that the position of the track sliding adjusting rod 14 can be fixed without the assistance of other devices.

Further, as shown in fig. 3, anti-slip pads 16 are provided at four corners of the bottom of the hollow box for preventing the fixing device from slipping during the fixing process.

The foregoing embodiments and description are merely illustrative of the principles of the utility model, and various changes and modifications can be made therein without departing from the spirit and scope of the utility model, which fall within the scope of the utility model as claimed.

Claims

1. A fixing device for experimental animals in a non-anesthesia state is characterized by comprising a base and two fixing units;

the base comprises an empty box (6) with an opening at the upper end and a lower bottom plate (7), and the lower bottom plate (7) is provided with two parallel grooves in a penetrating manner;

the fixing unit comprises an adjusting track (2) and two limb fixing rings (11), and the limb fixing rings (11) penetrate through the grooves;

the adjusting track (2) is arranged inside the empty box (6), and the adjusting track (2) comprises a sliding track (12), a track sliding assembly (13), a track fixing assembly (19) and a track sliding adjusting rod (14); the sliding rail (12) is fixed at a reserved position on the side wall of the empty box, the rail fixing component (19) is fixed at a preset position of the sliding rail (12), and the upper end of the rail fixing component is fixedly connected with a four-limb fixing ring (11); the track sliding assembly (13) is connected to the sliding track (12) in a sliding mode, the lower end of the track sliding assembly is fixedly connected with one end of the track sliding adjusting rod (14), the upper end of the track sliding adjusting rod is fixedly connected with another four-limb fixing ring (11), a preset hole (18) is reserved in the side wall of the empty box, and the free end of the track sliding adjusting rod (14) penetrates out of the preset hole (18).

2. The fixing device for the experimental animal in the non-anesthesia state as claimed in claim 1, wherein the lower bottom plate (7) is a transparent plate, the two ends of the lower bottom plate are provided with support legs, and a base gap (8) is arranged between the lower bottom plate (7) and the empty box (6) for placing the calibration paper.

3. A fixing device for non-anesthetized laboratory animals according to claim 1, characterized by further comprising a transparent upper cover plate (3), wherein the upper cover plate (3) is provided with a cover plate gap (10) for placing the calibration paper.

4. A fixing device for non-anesthetized experimental animals according to claim 3, characterized in that one corner of the upper cover plate (3) is connected with the lower base plate (7) through a hinge (9).

5. The fixing device for the experimental animal in the non-anesthesia state as claimed in claim 4, wherein an iron sheet is arranged at the diagonal position of one corner of the hinge connection between the upper cover plate (3) and the lower bottom plate (7), and a magnet is arranged at the position of the base corresponding to the iron sheet.

6. The fixing device for the experimental animal in the non-anesthesia state as claimed in claim 1, wherein the limb fixing ring (11) is an anti-slip elastic silica gel ring.

7. The fixing device for non-anesthetized laboratory animals according to claim 1, characterized in that the extremity fixing ring (11) is connected to the rail sliding assembly (13) by means of screws (15).

8. The fixing device for the experimental animal in the non-anesthesia state is characterized in that the part of the track sliding adjusting rod (14) which penetrates out of the side wall of the empty box (6) is provided with a screw rod (4) which is in threaded fit with a preset hole (18) which is provided with a threaded hole.