CN215611027U

CN215611027U - Transmission oscillation device for kit

Info

Publication number: CN215611027U
Application number: CN202122060194.2U
Authority: CN
Inventors: 赵海峰; 赵海涛
Original assignee: Changzhou Genmag Biotechnology Co ltd
Current assignee: Changzhou Genmag Biotechnology Co ltd
Priority date: 2021-08-30
Filing date: 2021-08-30
Publication date: 2022-01-25
Anticipated expiration: 2031-08-30

Abstract

The utility model provides a transmission oscillation device for a kit, which comprises: a support plate; the transmission mechanism is arranged on the supporting plate; the clamping mechanism is used for clamping the reagent kit and is connected with the transmission mechanism; and a controller for controlling the transmission mechanism and the clamping mechanism; the controller can control the clamping mechanism to clamp the reagent kit, and control the transmission mechanism to drive the clamping mechanism to reciprocate along the transverse direction, so as to drive the reagent kit to reciprocate, and further oscillate the reagent kit to mix the solution in the reagent kit.

Description

Transmission oscillation device for kit

Technical Field

The utility model relates to the technical field of automatic liquid treatment equipment, in particular to a transmission oscillation device for a kit.

Background

The full-automatic liquid treatment workstation is a biological medicine laboratory automatic operation platform which skillfully integrates automatic operation and liquid treatment, and can realize the operations of automatic sample adding, reagent distribution, ultra-micro liquid transfer, vibration, incubation and the like related to liquid treatment of a sample. Can be widely applied to the fields of nucleic acid purification, gene protein sequencing, clone rapid screening, cell culture, biochip sample preparation and the like. The liquid transfer mechanism is one of the core mechanisms of the full-automatic liquid treatment workstation and is used for realizing the actions of conveying, extracting, transferring and the like of liquid among standard liquid containers.

In the use of modern fully automated liquid handling workstations, the most common standard liquid containers are kits such as 8-well plates, 96-well plates, and the like. Wherein, the spacing between adjacent holes of standard liquid containers such as 96-hole plates and the like commonly used in laboratories is 9mm at least, the volume is about 0.5ml, and 8 holes are distributed in a single row. Automated liquid handling stations, particularly pipetting mechanisms therein, typically require agitation of the reagent cartridges for adequate mixing of the reagents within the cartridges at the time of dispensing. However, the conventional pipetting apparatus does not have an oscillation function, and usually requires an operator to manually oscillate and mix the reagent before use, which causes problems of low mixing efficiency, increased workload on the operator, and insufficient mixing and omission.

SUMMERY OF THE UTILITY MODEL

In view of the technical problems described above, the present invention is directed to a driven oscillation device for reagent cartridges, which can oscillate reagent cartridges while transferring the reagent cartridges so that reagents in the reagent cartridges can be sufficiently mixed.

To this end, according to the utility model, a driven oscillation device for a reagent cartridge is proposed, comprising: a support plate; the transmission mechanism is arranged on the supporting plate; the clamping mechanism is used for clamping the reagent kit and is connected with the transmission mechanism; and a controller for controlling the transmission mechanism and the clamping mechanism; the controller can control the clamping mechanism to clamp the reagent kit, and control the transmission mechanism to drive the clamping mechanism to reciprocate along the transverse direction, so as to drive the reagent kit to reciprocate, and further oscillate the reagent kit to mix the solution in the reagent kit.

In one embodiment, the transmission mechanism includes two timing belts spaced apart from each other and arranged in parallel, and two first driving motors for driving the timing belts.

In one embodiment, the first driving motor is fixedly installed at the lower end of the support plate by a motor installation plate, and an output shaft of the first driving motor protrudes upward through the support plate.

In one embodiment, the output shaft of the first driving motor is provided with a driving wheel, the supporting plate is provided with a driven wheel which is spaced from the driving wheel in the transverse direction, the synchronous belt is matched and mounted on the driving wheel and the driven wheel, and the first driving motor can drive the driving wheel to drive the synchronous belt to move.

In one embodiment, the driven wheel is mounted to the support plate through a mounting seat, the mounting seat is configured to comprise a main body portion and a support portion perpendicularly connected with the main body portion, and the driven wheel is mounted between the support portion and the support plate through a rotating shaft.

In one embodiment, the clamping mechanism comprises two second driving motors which are symmetrically distributed in the longitudinal direction, the second driving motors are fixedly connected with the corresponding synchronous belts through motor supporting plates respectively,

the output shaft of the second driving motor is provided with a telescopic sleeve, the second driving motor can drive the telescopic sleeve to extend out to clamp the reagent kit, and the reagent kit is driven to move under the action of the synchronous belt to oscillate.

In one embodiment, the end of the telescopic sleeve is provided with a clamping block, the clamping block can be matched with a clamping groove in the side wall of the reagent box, so that the reagent box can be clamped, and the clamping block can drive the reagent box to incline.

In one embodiment, the motor support plate clamps the timing belt through a connection plate, thereby forming a fixed connection with the timing belt.

In one embodiment, the clamping mechanism further comprises guide slide rails symmetrically distributed on two longitudinal sides of the supporting plate, the guide slide rails are provided with supporting slide blocks,

the motor supporting plate is fixedly connected with the supporting slide block, so that the second driving motor can reciprocate along the guide slide rail.

In one embodiment, the controller is in signal connection with two first driving motors of the transmission mechanism and two second driving motors of the clamping mechanism respectively, and enables the two first driving motors to operate synchronously and the two second driving motors to operate synchronously.

Compared with the prior art, the utility model has the advantages that:

the transmission oscillation device for the kit is suitable for a pipetting workstation, and can meet the automatic work of the pipetting workstation. The transmission oscillation device can oscillate the reagent kit while conveying the reagent kit 200 so as to enable reagents in the reagent kit to be fully mixed, thereby realizing automatic mixing of solutions in the reagent kit and being very favorable for improving the working efficiency of a liquid transfer workstation. And the transmission oscillation device has simple structure, convenient operation and low manufacturing cost and maintenance cost.

Drawings

The utility model will now be described with reference to the accompanying drawings.

Fig. 1 adaptively shows the structure of a driven oscillation device for a reagent cartridge according to the present invention.

Fig. 2 is an exploded view of the driven oscillating unit shown in fig. 1.

In the present application, the drawings are all schematic and are used only for illustrating the principles of the utility model and are not drawn to scale.

Detailed Description

The utility model is described below with reference to the accompanying drawings.

In the present invention, it should be noted that the direction along the X axis in fig. 1 is defined as the horizontal direction, the direction along the Y axis in fig. 1 is defined as the vertical direction, and the direction along the Z axis in fig. 1 is defined as the vertical direction. It is further noted that the terms "upper", "lower", "front", "rear", and the like, indicate orientations or positional relationships based on the orientations or positional relationships shown in the drawings, are merely for convenience in describing the present invention and simplifying the description, and do not indicate or imply that the referred devices or elements must have a specific orientation, be constructed in a specific orientation, and be operated, and thus should not be construed as limiting the present invention.

Fig. 1 adaptively shows the structure of a driven oscillation device 100 for a reagent cartridge according to the present invention. As shown in fig. 1, the driven oscillation device 100 includes a support plate 1, a driving mechanism 2, a holding mechanism 3, and a controller (not shown). The transmission mechanism 2 is provided on the support plate 1 and arranged in the lateral direction. The clamping mechanism 3 is connected with the transmission mechanism 2, and the clamping mechanism 3 is used for clamping the reagent kit 200. The controller is used for controlling the operation of the transmission mechanism 2 and the clamping mechanism 3. When the device works, the controller can control the clamping mechanism 3 to clamp the reagent box 200, and control the transmission mechanism 2 to drive the clamping mechanism 3 to reciprocate along the transverse direction, so as to drive the reagent box 200 to reciprocate, and further oscillate the reagent box 200 to mix the solution in the reagent box 200.

In one embodiment, the support plate 1 comprises two rectangular plates and a connection main plate connected between the two rectangular plates, the connection main plate being disposed at one end of the two rectangular plates, so that the support plate 2 forms a U-shaped plate-like structure.

According to the present invention, as shown in fig. 1 and 2, the transmission mechanism 2 includes two timing belts 21 and two first driving motors 22 for driving the timing belts 21. Preferably, the two timing belts 21 are respectively installed on a rectangular plate and arranged in a transverse direction such that the two timing belts 21 are spaced apart from each other and are parallel to each other. The first driving motor 22 is fixedly installed at the lower end of the support plate 1 by a motor installation plate 221, and the output shaft of the first driving motor 22 protrudes upward through the support plate 1. The motor mounting plate 221 is disposed on the upper end surface of the support plate 1, and the first driving motor 22 is fixed to the lower end surface of the support plate 1 by a bolt and nut assembly.

As shown in fig. 2, the transmission mechanism 2 further includes a driving pulley 23 and a driven pulley 24 for realizing the transmission of the timing belt 21. Each timing belt 21 is provided with a driving pulley 23 and a driven pulley 24. The driving wheel 23 is mounted on an output shaft of the first driving motor 22, the driven wheel 24 is mounted on the support plate 1 through a mounting seat 25, and the driven wheel 24 is distributed in a laterally spaced manner from the driving wheel 23. The synchronous belt 21 is mounted on the driving wheel 23 and the driven wheel 24 in a matching manner, and the driving wheel 23 can be driven to rotate by the first driving motor 22, so that the synchronous belt 21 is driven to move.

In the present embodiment, the mount 25 is configured to include a body portion 251 and a support portion 252 perpendicularly connected to the body portion 251. The main body portion 251 is fixedly connected with the support plate 1, and an installation space is formed between the support portion 252 and the support plate 1, and the driven wheel 24 is installed in the installation space through a rotating shaft. Preferably, in order to facilitate the installation of the timing belt 21, the mounting seat 25 may be provided to be adjustable, enabling the installation position on the support plate 1 to be adjusted.

According to the present invention, the clamping mechanism 3 comprises two second driving motors 31 symmetrically distributed in the longitudinal direction, and the second driving motors 31 are fixedly connected with the corresponding synchronous belts 21 through motor supporting plates 32 respectively. The output shaft of the second driving motor 31 is provided with a telescopic sleeve 311, and the second driving motor 31 can drive the telescopic sleeve 311 to extend out to clamp the reagent kit 200 and drive the reagent kit 200 to move under the action of the synchronous belt 21, so as to oscillate the reagent kit 200.

As shown in fig. 2, the motor support plate 32 is configured in a rectangular plate shape, and a through hole is provided on the motor support plate 32. The second drive motor 31 is fixed to the longitudinal outer side of the motor support plate 32, and the output shaft of the second drive motor 31 extends longitudinally inward through the through hole. The second driving motor 31 drives the output shaft to rotate so as to drive the telescopic sleeve 311 to perform telescopic motion. The motor support plate 32 clamps the timing belt 21 through the connection plate 33. The connection plate 33 is also configured in a rectangular plate shape, the timing belt 21 is disposed between the motor support plate 32 and the connection plate 33, and the motor support plate 32 and the connection plate 33 are in fastening connection by a bolt and nut assembly, thereby fixedly clamping the timing belt 21 to the motor support plate 32 and the connection plate 33. Thereby, the timing belt 21 can drive the motor support plate 32 to move synchronously with the second driving motor 31.

In one embodiment, a clamping block 34 may be provided at the end of the telescopic sleeve 311, and the clamping block 34 can be adapted to the slot 201 on the side wall of the reagent cartridge 200, thereby clamping the reagent cartridge 200. Preferably, the clamping block 34 is configured to be non-circular, and the catch slot 201 on the side wall of the reagent vessel 200 is also non-circular. Therefore, in the reciprocating oscillation process, the second driving motor 31 rotates in a small amplitude, so that the clamping block 34 can drive the reagent kit 200 to slightly incline, and the oscillation effect on the reagent kit is enhanced. It should be understood that the second driving motor 31 is rotated by a small angle to prevent the clamping block 34 from being retracted and disengaged from the slot 201 on the side wall of the reagent cartridge 200.

According to the present invention, as shown in fig. 2, the clamping mechanism 3 further includes guide rails 35 symmetrically disposed on both longitudinal sides of the supporting plate 1, and the guide rails 35 are provided with supporting sliders 36. The motor support plate 32 is fixedly coupled to the support slider 36 so that the second driving motor 31 can reciprocate along the guide rail 35. On the one hand, the guide rail 35 can guide the second drive motor 31 and on the other hand can support the second drive motor 31 via the support slide 36. This is very advantageous in ensuring the stable support of the second driving motor 31, thereby ensuring the stability and reliability of the holding mechanism 3.

In an embodiment, which is not shown, the controller is in signal connection with the two first drive motors 22 of the transmission 2 and the two second drive motors 31 of the gripper 3, respectively, and the controller controls the two first drive motors 22 and the two second drive motors 31 to operate synchronously. Therefore, the two synchronous belts 21 of the transmission mechanism 2 are kept to move synchronously, and the two second driving motors 31 in the clamping mechanism 3 are kept to drive the corresponding telescopic sleeves 311 to move synchronously in a telescopic manner, so that the control accuracy and reliability of the transmission oscillation device 100 are ensured.

In practical use of the driving oscillation apparatus 100 for reagent cartridges according to the present invention, first, the reagent cartridge 200 filled with the solution is placed between the two timing belts 21 of the driving mechanism 2, and the holding blocks 34 at the output ends of the two second driving motors 31 in the holding mechanism 3 are aligned with the corresponding card slots 201 on the reagent cartridge 200. The two second driving motors 31 are controlled by the controller to synchronously operate to drive the corresponding telescopic sleeves 311 to longitudinally extend inwards, so that the clamping blocks 34 are matched with the corresponding clamping grooves 201, and the clamping mechanism 3 clamps the reagent kit 200. Then, the controller controls the two first driving motors 22 in the transmission mechanism 2 to synchronously move so as to drive the two synchronous belts 21 to synchronously move in a reciprocating manner, so that the synchronous belts 21 drive the two second driving motors 31 to reciprocate, and further drive the reagent kit 200 to reciprocate, thereby forming an oscillating action on the reagent kit 200. After the oscillation for a period of time, the solution in the reagent kit 200 is sufficiently mixed, thereby completing the oscillation of the reagent kit 200 and completing the solution mixing.

The transmission oscillation device 100 for reagent kit according to the present invention is suitable for a pipetting station, and can satisfy the automation work of the pipetting station. The transmission oscillation device 100 can oscillate the reagent kit 200 while conveying the reagent kit 200, so that reagents in the reagent kit 200 can be fully mixed, the automatic mixing of solutions in the reagent kit is realized, and the improvement of the working efficiency of a liquid transfer workstation is greatly facilitated. The transmission oscillation device 100 has a simple structure, is convenient to operate, and has low manufacturing cost and maintenance cost.

In the description of the present invention, it is to be understood that the terms "first", "second" and the like are used for descriptive purposes only and are not to be construed as indicating or implying relative importance or implying any number of technical features indicated. Thus, a feature defined as "first" or "second" may explicitly or implicitly include one or more of that feature. In the description of the present invention, "a plurality" means two or more unless specifically defined otherwise.

In the present invention, unless otherwise expressly specified or limited, the terms "mounted," "connected," "secured," and the like are to be construed broadly and can, for example, be fixedly connected, detachably connected, or integrally connected; can be mechanically or electrically connected; they may be connected directly or indirectly through intervening media, or they may be interconnected between two elements. The specific meanings of the above terms in the present invention can be understood by those skilled in the art according to specific situations.

In the description herein, references to the description of the term "one embodiment," "some embodiments," "an example," "a specific example," or "some examples," etc., mean that a particular feature, structure, material, or characteristic described in connection with the embodiment or example is included in at least one embodiment or example of the utility model. In this specification, the schematic representations of the terms used above do not necessarily refer to the same embodiment or example. Furthermore, the particular features, structures, materials, or characteristics described may be combined in any suitable manner in any one or more embodiments or examples.

Finally, it should be noted that the above-mentioned embodiments are only preferred embodiments of the present invention, and do not limit the present invention. Although the present invention has been described in detail with reference to the foregoing embodiments, it will be apparent to those skilled in the art that modifications may be made to the embodiments described in the foregoing examples, or that equivalents may be substituted for elements thereof. Any modification, equivalent replacement, or improvement made within the spirit and principle of the present invention should be included in the protection scope of the present invention.

Claims

1. A driven oscillation device for a reagent cartridge, comprising:

a support plate (1);

a transmission mechanism (2) arranged on the supporting plate;

a gripping mechanism (3) for gripping a reagent cartridge (200), said gripping mechanism being in connection with said transmission mechanism; and

a controller for controlling the drive mechanism and the clamping mechanism;

the controller can control the clamping mechanism to clamp the reagent kit, and control the transmission mechanism to drive the clamping mechanism to reciprocate along the transverse direction, so as to drive the reagent kit to reciprocate, and further oscillate the reagent kit to mix the solution in the reagent kit.

2. The driven oscillation device of claim 1, wherein the driving mechanism comprises two timing belts (21) and two first driving motors (22) for driving the timing belts, the two timing belts being spaced apart from each other and arranged in parallel.

3. The transmission oscillation apparatus of claim 2 wherein the first drive motor is fixedly mounted at a lower end of the support plate by a motor mounting plate (221), and an output shaft of the first drive motor protrudes upward through the support plate.

4. The transmission oscillation device of claim 3 wherein the output shaft of the first drive motor is mounted with a drive pulley (23), the support plate is provided with a driven pulley (24) laterally spaced from the drive pulley, the timing belt is adapted to be mounted to the drive pulley and the driven pulley, and the first drive motor is capable of driving the drive pulley to move the timing belt.

5. The driven oscillation device of claim 4 wherein the driven wheel is mounted to the support plate by a mount (25),

the mounting seat is configured to include a main body portion (251) and a support portion (252) perpendicularly connected to the main body portion, and the driven wheel is mounted between the support portion and the support plate through a rotating shaft.

6. The transmission oscillation device of claim 2, wherein the clamping mechanism comprises two second driving motors (31) symmetrically distributed in the longitudinal direction, the second driving motors are fixedly connected with the corresponding synchronous belts respectively through motor supporting plates (32),

an output shaft of the second driving motor is provided with a telescopic sleeve (311), the second driving motor can drive the telescopic sleeve to extend out to clamp the reagent kit, and the reagent kit is driven to move under the action of the synchronous belt to oscillate.

7. The transmission oscillation device of claim 6, wherein the end of the telescopic sleeve is provided with a clamping block (34), the clamping block can be matched with a clamping groove (201) on the side wall of the reagent box so as to clamp the reagent box, and the clamping block can drive the reagent box to incline.

8. The driven oscillation device of claim 6 wherein the motor support plate clamps the timing belt through a connection plate (33) to form a fixed connection with the timing belt.

9. The transmission oscillation device of claim 6 or 8, wherein the clamping mechanism further comprises guide rails (35) symmetrically distributed on both longitudinal sides of the support plate, the guide rails being provided with support sliders (36),

10. The transmission oscillation apparatus of claim 6 wherein the controller is in signal communication with two first drive motors of the transmission mechanism and two second drive motors of the clamping mechanism, respectively, and synchronizes operation of the two first drive motors and the two second drive motors.