CN215388961U

CN215388961U - Novel magnetic particle reagent mixing cleaning equipment

Info

Publication number: CN215388961U
Application number: CN202121451759.3U
Authority: CN
Inventors: 张长龙; 付先齐; 彭峰; 周扬; 陈婷婷
Original assignee: Wuhan Huada Gene Biomedical Engineering Co ltd
Current assignee: Wuhan Huada Gene Biomedical Engineering Co ltd
Priority date: 2021-06-28
Filing date: 2021-06-28
Publication date: 2022-01-04
Anticipated expiration: 2031-06-28

Abstract

A novel magnetic particle reagent mixing and cleaning device comprises: a frame; a reaction cup holder with a plurality of reaction cup bins; the magnetic driving device is arranged corresponding to the reaction cup bin and drives the magnetic particles in the reaction cup to move by changing the direction of the magnetic field so as to uniformly mix the reagent or clean the reagent; a control device connected to the power supply; the first transmission shaft assembly is arranged on the rack and is in transmission connection with the reaction cup holder; the driving device is fixedly assembled on the frame; the transmission device is connected with the driving device at one end and connected with the first transmission shaft assembly at the other end; and the positioning device is partially assembled on the first transmission shaft assembly or the transmission device in a transmission manner, is partially assembled on the rack, is electrically connected with the control device, and is used for controlling the reaction cup holder to move and enabling the reaction cup bin to stay at the position corresponding to the magnetic driving device for a preset time in sequence. By adopting the technical scheme, the reaction cup has the advantages of fully mixing uniformly and effectively preventing the reaction cup from falling and splashing.

Description

Novel magnetic particle reagent mixing cleaning equipment

Technical Field

The utility model relates to the technical field of in-vitro diagnosis equipment, in particular to novel magnetic particle reagent mixing and cleaning equipment.

Background

Magnetic particles refer to colloidal composite materials that can be uniformly dispersed in a certain base liquid. Because of the properties of superparamagnetism, higher specific surface area, capability of modifying functional groups and the like. Thus, antigens/antibodies, enzymes, nucleic acids/oligonucleotides, small molecule drugs, etc. are immobilized on their surfaces.

At present, magnetic particle reagents are generally mixed through mechanical oscillation, specifically, a reaction cup is grabbed to a mixing device through a manipulator to be oscillated and mixed, and in the process, the reaction cup is easy to drop and splash, so that the material loss is caused, and the normal operation of the operation is influenced to a certain extent, so that improvement is needed.

SUMMERY OF THE UTILITY MODEL

The utility model aims to provide novel magnetic particle reagent mixing and cleaning equipment aiming at the defects and shortcomings in the prior art, and the equipment has the advantages of fully mixing, and effectively preventing a reaction cup from falling and splashing.

In order to achieve the purpose, the utility model adopts the technical scheme that: a novel magnetic particle reagent mixing and cleaning equipment comprises: a frame; a reaction cup holder with a plurality of reaction cup bins; the magnetic driving device is arranged corresponding to the reaction cup bin and drives the magnetic particles in the reaction cup to move by changing the direction of the magnetic field so as to uniformly mix the reagent or clean the reagent; and the control device is connected with the power supply and is used for controlling the magnetic driving device to change the magnetic field.

Novel magnetism particle reagent mixing cleaning equipment still includes: the first transmission shaft assembly is arranged on the rack and is in transmission connection with the reaction cup holder; the driving device is fixedly assembled on the rack and electrically connected with the control device; the transmission device is connected with the driving device at one end and connected with the first transmission shaft assembly at the other end; and the positioning device is partially assembled on the first transmission shaft assembly or the transmission device in a transmission manner, is partially assembled on the rack, is electrically connected with the control device, and is used for controlling the reaction cup holder to move and enabling the reaction cup bin to stay at the position corresponding to the magnetic driving device for a preset time in sequence.

The positioning device includes: the first correlation switch is fixedly assembled on the rack and electrically connected with the control device; and the coded disc is assembled on the first transmission shaft assembly or the transmission device and positioned between the first correlation switches, and the grids on the coded disc correspond to the reaction cup bins one by one.

The rack is also provided with a second opposite-jet switch, the coded disc is provided with a stop block corresponding to the second opposite-jet switch, and the stop block acts on the second opposite-jet switch when rotating to the original point along with the coded disc so as to control the driving device to stop.

And the rack is provided with a mounting plate for mounting the first correlation switch and the second correlation switch.

The transmission device includes: a second drive shaft assembly mounted to the frame; a first synchronous belt transmission component assembled on the second transmission shaft component and the driving device; and a second synchronous belt drive assembly assembled between the first drive shaft assembly and the second drive shaft assembly.

The magnetic driving device includes: the first electromagnet and the second electromagnet are arranged on the reaction cup holder or the rack, are positioned on two opposite sides of the reaction cup bin, can alternately act on the magnetic particles, and are electrically connected with the control device.

The reaction cup holder comprises: the reaction cup bin is arranged on the rotary table close to the edge along the circumferential direction; and the fixed disk is fixedly assembled on the rack, is positioned between the rotary disk and the rack and is coaxially arranged with the rotary disk, an annular groove is formed in the fixed disk corresponding to the reaction cup bin, and mounting holes for mounting the first electromagnet and the second electromagnet are formed in the wall of the annular groove.

The magnetic driving device includes: the motor is fixedly arranged on the rack; and the permanent magnet is assembled on the output shaft of the motor in a transmission manner and rotates around the reaction cup.

The permanent magnet is provided with a connecting end assembled with the output shaft, an offset end connected with the connecting end and extending in the radial direction, and an acting end connected with the offset end far away from the connecting end.

After the technical scheme is adopted, the utility model has the beneficial effects that: the magnetic driving device is adopted, and the magnetic field direction of the magnetic driving device acting on the magnetic particles is controlled to drive the magnetic particles in the reagent to move, so that the effect of uniformly mixing the reagent or cleaning is achieved, the problems of dropping and splashing of the reaction cup are effectively avoided, and the ordered mixing operation is ensured to a certain extent while the waste of materials is avoided.

Drawings

In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings used in the description of the embodiments or the prior art will be briefly described below, and it is obvious that the drawings in the following description are only some embodiments of the present invention, and for those skilled in the art, other drawings can be obtained according to these drawings without creative efforts.

FIG. 1 is a first structural schematic diagram of embodiment 1 of the present invention;

fig. 2 is a second schematic structural view of embodiment 1 of the present invention;

FIG. 3 is an enlarged view corresponding to detail A in FIG. 2;

fig. 4 is an exploded view of embodiment 1 of the utility model;

FIG. 5 is a schematic view of the first driveshaft assembly, second driveshaft assembly and frame structure of the present invention;

FIG. 6 is a sectional view taken along the section of FIG. 5;

FIG. 7 is a schematic structural view of embodiment 2 of the present invention;

fig. 8 is an enlarged view of detail B corresponding to fig. 7.

Description of reference numerals: 1. a frame; 11. a base plate; 12. a top plate; 121. a first adjustment aperture; 122. a second plurality of adjustment holes; 13. a pillar; 14. a reaction cup bin; 15. mounting a plate; 2. a reaction cup holder; 21. a turntable; 22. fixing the disc; 221. an annular groove; 222. mounting holes; 3. a drive device; 4. a magnetic drive device; 41. a first electromagnet; 42. a second electromagnet; 43. a motor; 44. a permanent magnet; 441. a connecting end; 442. an offset end; 443. an action end; 5. a control device; 6. a reaction cup; 7. a first drive shaft assembly; 71. a first rotating shaft; 72. a first bearing; 73. a first bushing; 8. a transmission device; 81. a second driveshaft assembly; 811. a second rotating shaft; 812. a second bearing; 813. a second shaft sleeve; 82. a first synchronous belt drive assembly; 83. a second synchronous belt transmission assembly; 9. a positioning device; 91. a first correlation switch; 92. code disc; 93. a second correlation switch; 94. and a stop block.

Detailed Description

The present invention will be described in further detail with reference to the accompanying drawings.

The present embodiment is only for explaining the present invention, and it is not limited to the present invention, and those skilled in the art can make modifications of the present embodiment as necessary without making a contribution thereto after reading the present specification, but all are protected by patent laws within the scope of the claims of the present invention.

Example 1

The embodiment relates to a novel magnetic particle reagent mixing and cleaning device, as shown in fig. 1, comprising: the device comprises a machine frame 1, a reaction cup holder 2, a magnetic driving device 4 and a control device 5.

Wherein, the reaction cup holder 2 is provided with at least 1 reaction cup bin 14. The magnetic driving device 4 is arranged corresponding to the reaction cup bin 14, and the control device 5 is connected with the power supply and the magnetic driving device 4 and is used for controlling the magnetic driving device 4 to change the magnetic field. When a reaction cup containing a solution with magnetic particles is placed in the reaction cup chamber 14, the magnetic driving device 4 intermittently and repeatedly changes the direction of the magnetic field to drive the magnetic particles to move back and forth, so as to be fully mixed with the reagent or cleaned. Can prevent the reaction cup from falling and splashing.

Further, in order to improve the efficiency of reagent mixing. This novel magnetism particle reagent mixing cleaning equipment still includes: a first transmission shaft assembly 7, a driving device 3, a transmission device 8 and a positioning device 9.

As shown in fig. 1, the reaction cup bins 14 are two or more in number and are arranged equidistantly along the circumference of the reaction cup holder 2. The first transmission shaft assembly 7 is assembled on the frame 1 on the top plate 12, and one end of the first transmission shaft assembly is in transmission connection with the reaction cup holder 2. The driving device 3 is fixedly assembled on the frame 1 and is electrically connected with the control device 5. Preferably, the driving means 3 is a motor. One end of the transmission device 8 is connected with the driving device 3, and the other end is connected with the first transmission shaft assembly 7. A part of the positioning device 9 is arranged on the first transmission shaft assembly 7 or the transmission device 8 in a transmission manner, a part of the positioning device is arranged on the frame 1, and the positioning device is electrically connected with the control device 5 and is used for controlling the driving device 3 through the control device 5 to control the reaction cup holder 2 to move so as to enable the reaction cup bins 14 to stay at the positions corresponding to the magnetic driving device 4 in sequence for a preset time, wherein the preset time is the time required for uniformly mixing the reagents in the single reaction cup, and during the period, the magnetic driving device 4 is used for uniformly mixing or cleaning the magnetic particles and the reagents.

Further, as shown in fig. 2 and 3, the positioning device 9 includes: a first correlation switch 91 and a code wheel 92. The first correlation switch 91 is fixedly mounted on the frame 1 and electrically connected to the control device 5. The code wheel 92 is fixedly mounted on the transmission 8 between the emitting end and the receiving end of the first correlation switch 91, and the code wheel 92 is also mounted on the first transmission shaft assembly 7. The grids on the code disc 92 correspond to the reaction cup bins 14 one by one.

When the driving device 3 is started, the first transmission shaft assembly 7 can be driven to rotate through the transmission device 8, so that the coded disc 92 and the reaction cup holder 2 are driven to rotate, when the reaction cups corresponding to the magnetic driving device 4 are replaced, the first ejection switch 91 is located at the grid, the driving device 3 can be controlled to stop through the control switch, and then the magnetic driving device 4 is controlled by the control device 5 to work so as to uniformly mix the reagents in the reaction cups.

Further, a second correlation switch 93 is further arranged on the rack 1, a stopper 94 is arranged on the code disc 92 corresponding to the second correlation switch 93, and when the stopper 94 rotates to the origin along with the code disc 92, the stopper acts on the second correlation switch 93 to control the driving device 3 to stop, so that the uniform mixing of all the reagents on the reaction cup holder 2 is completed.

Further, the rack 1 includes a bottom plate 11, a top plate 12, and a plurality of support columns 13 installed between the bottom plate 11 and the top plate 12. An L-shaped mounting plate 15 for mounting the first correlation switch 91 and the second correlation switch 93 is arranged on one side of the top plate 12 close to the bottom plate 11.

Further, the transmission 8 includes: a second drive shaft assembly 81, a first synchronous belt drive assembly 82 and a second synchronous belt drive assembly 83. The first transmission shaft assembly 7 is connected with the reaction cup holder 2 through one end of the top plate 12. The second transmission shaft assembly 81 is inserted into one end of the top plate 12 and connected to the driving device 3 through a first synchronous belt transmission assembly 82, and the other end of the second transmission shaft assembly 81 is connected to the other end of the first transmission shaft assembly 7 through a second synchronous belt transmission assembly 83.

As shown in fig. 5 and 6, the first transmission shaft assembly 7 includes: a first shaft 71, a first bearing 72 and a first sleeve 73. The first shaft 71 is stepped, the first sleeve 73 is sleeved outside the first shaft 71, and one end of the first sleeve is fixed to the top plate 12 through screws. The first bearings 72 include three bearings, each of which is disposed between the first shaft sleeve 73 and the first rotating shaft 71 and located at both ends of the first shaft sleeve 73, and plays a role of bearing the first rotating shaft 71.

The first driveshaft assembly 7 is located between the first driveshaft assembly 7 and the drive assembly, and the second driveshaft assembly 81 includes: a second shaft 811, a second bearing 812 and a second sleeve 813. The second shaft 811 is stepped, and the second sleeve 813 is sleeved outside the second shaft 811. The second bearings 812 include two second bearings 812, and the two second bearings 812 are disposed between the second sleeve 813 and the second rotating shaft 811 and located at two ends of the second sleeve 813, and play a role in bearing the second rotating shaft 811. The top plate 12 is provided with a first adjusting hole 121, one end of the second bearing 812 and the top plate 12 are fixed on the first adjusting hole 121 through screws, and the second bearing 812 can adjust the distance from the first rotating shaft 71 or the driving device 3 to tension or loosen the second synchronous belt transmission assembly 83. The top plate 12 is further provided with a second adjustment hole for mounting the driving device 3, and the second adjustment hole is used for realizing the adjustment of the distance from the second transmission shaft assembly 81 to tension or release the first timing belt transmission assembly 82.

Further, as shown in fig. 4, the magnetic driving device 4 includes: a first electromagnet 41 and a second electromagnet 42. The first electromagnet 41 and the second electromagnet 42 are electrically connected to the control device 5, and are respectively disposed on the reaction cup holder 2 or the rack 1, located on two opposite sides of the reaction cup chamber 14, and capable of alternately acting on the magnetic particles. The first electromagnet 41 and the second electromagnet 42 change the magnetic field acting on the magnetic particles by turning off the current, so as to drive the magnetic particles to reciprocate, thereby achieving the effect of uniformly mixing or cleaning.

Further, the reaction cup holder 2 includes: a turntable 21 and a fixed disk 22. The turntable 21 is assembled with the first transmission shaft assembly 7, and the reaction cup bin 14 is arranged on the turntable 21 along the circumferential direction and close to the edge. The fixed disk 22 is fixedly assembled on the frame 1 between the rotary disk 21 and the frame 1 and is coaxially arranged with the rotary disk 21, an annular groove 221 is arranged on the fixed disk 22 corresponding to the reaction cup chamber 14, and mounting holes 222 for mounting the first electromagnet 41 and the second electromagnet 42 are arranged on the wall of the annular groove 221. One or more magnetic driving devices 4 are provided.

Example 2

The main difference between this embodiment and embodiment 1 is that, as shown in fig. 7 and 8, the magnetic drive device 4 includes: a motor 43 and a permanent magnet 44. The motor 43 is electrically connected with the control device 5 and is fixedly arranged on one side of the top plate 12 close to the reaction cup holder 2. The permanent magnet 44 is drivingly mounted on the output shaft of the motor 43 and is rotatable about the reaction cup to vary the magnetic field applied to the magnetic particles.

Further, the permanent magnet 44 is provided with a connecting end 441 to be fitted to the output shaft, an offset end 442 connected to the connecting end 441 and extending in a radial direction, and an acting end 443 connected to the offset end 442 away from the connecting end 441.

The above description is only for the purpose of illustrating the technical solutions of the present invention and not for the purpose of limiting the same, and other modifications or equivalent substitutions made by those skilled in the art to the technical solutions of the present invention should be covered by the claims of the present invention without departing from the spirit and scope of the technical solutions of the present invention.

Claims

1. The utility model provides a novel magnetic particle reagent mixing cleaning equipment which characterized in that includes: a frame (1);

a reaction cup holder (2) with a plurality of reaction cup bins (14);

the magnetic driving device (4) is arranged corresponding to the reaction cup bin (14) and drives the magnetic particles in the reaction cup to move by changing the direction of the magnetic field so as to uniformly mix the reagent or clean the reagent; and the number of the first and second groups,

and the control device (5) is connected with the power supply and is used for controlling the magnetic drive device (4) to change the magnetic field.

2. The novel magnetic particle reagent blending and cleaning device according to claim 1, further comprising:

the first transmission shaft assembly (7) is arranged on the rack (1) and is in transmission connection with the reaction cup holder (2);

the driving device (3) is fixedly assembled on the rack (1) and is electrically connected with the control device (5);

a transmission device (8) with one end connected with the driving device (3) and the other end connected with the first transmission shaft component (7); and the number of the first and second groups,

a positioning device (9) which is partially assembled on the first transmission shaft assembly (7) or the transmission device (8) in a transmission way, is partially assembled on the rack (1), is electrically connected with the control device (5) and is used for controlling the reaction cup holder (2) to move and enabling the reaction cup bin (14) to stay at a position corresponding to the magnetic driving device (4) for a preset time in sequence.

3. The novel magnetic particle reagent mixing and cleaning device as claimed in claim 2, wherein the positioning device (9) comprises:

a first correlation switch (91) fixedly assembled on the frame (1) and electrically connected with the control device (5); and the number of the first and second groups,

and the coded disc (92) is assembled on the first transmission shaft assembly (7) or the transmission device (8) and positioned between the first correlation switches (91), and gratings on the coded disc (92) correspond to the reaction cup bins (14) one by one.

4. The novel magnetic particle reagent mixing and cleaning device as claimed in claim 3, wherein a second correlation switch (93) is further disposed on the rack (1), a stopper (94) is disposed on the code disc (92) corresponding to the second correlation switch (93), and when the stopper (94) rotates to an origin along with the code disc (92), the stopper acts on the second correlation switch (93) to control the driving device (3) to stop.

5. The novel magnetic particle reagent mixing and cleaning device as claimed in claim 4, wherein the rack (1) is provided with a mounting plate (15) for mounting the first correlation switch (91) and the second correlation switch (93).

6. The novel magnetic particle reagent blending cleaning device according to claim 3, wherein the transmission device (8) comprises: a second transmission shaft assembly (81) assembled on the frame (1);

a first synchronous belt drive assembly (82) mounted on the second drive shaft assembly (81) and the drive device (3); and the number of the first and second groups,

a second synchronous belt drive assembly (83) assembled between the first drive shaft assembly (7) and the second drive shaft assembly (81).

7. The novel magnetic particle reagent mixing and cleaning device according to any one of claims 1 to 6, wherein the magnetic driving device (4) comprises: a first electromagnet (41) and a second electromagnet (42) which are arranged on the reaction cup holder (2) or the frame (1), are positioned on two opposite sides of the reaction cup bin (14), can alternately act on the magnetic particles, and are electrically connected with the control device (5).

8. The novel magnetic particle reagent mixing and cleaning device according to claim 7, wherein the reaction cup holder (2) comprises: the reaction cup bin (14) is arranged on the rotary table (21) close to the edge along the circumferential direction; and the number of the first and second groups,

the fixed assembly in frame (1) go up to be located carousel (21) with between frame (1), and with fixed disk (22) of carousel (21) coaxial setting, correspond on fixed disk (22) reaction cup storehouse (14) are equipped with ring channel (221), be equipped with the confession on ring channel (221) wall first electro-magnet (41) with mounting hole (222) of second electro-magnet (42) installation.

9. The novel magnetic particle reagent mixing and cleaning device according to any one of claims 1 to 6, wherein the magnetic driving device (4) comprises:

a motor (43) fixedly mounted on the frame (1); and the number of the first and second groups,

and the permanent magnet (44) is assembled on the output shaft of the motor (43) in a transmission way and rotates around the reaction cup.

10. The novel magnetic particle reagent blending and cleaning device as claimed in claim 9, wherein the permanent magnet (44) is provided with a connecting end (441) assembled with the output shaft; a radially extending offset end (442) connected to the connecting end (441); and an action end (443) connected to the offset end (442) away from the connection end (441).