CN217392204U

CN217392204U - Vibration subassembly and mixing device

Info

Publication number: CN217392204U
Application number: CN202221311002.9U
Authority: CN
Inventors: 张长龙; 邓英龙; 付先齐; 彭峰; 周扬; 陈婷婷
Original assignee: Wuhan Huada Gene Biomedical Engineering Co ltd
Current assignee: Wuhan Huada Gene Biomedical Engineering Co ltd
Priority date: 2022-05-23
Filing date: 2022-05-23
Publication date: 2022-09-09
Anticipated expiration: 2032-05-23

Abstract

The utility model provides a vibration subassembly and mixing device relates to external diagnostic equipment technical field, and the vibration subassembly includes casing, slider, resets and ultrasonic transducer. The sliding piece is connected with the shell in a sliding mode. The reset piece is connected with the sliding piece and the shell, and the sliding piece can slide relative to the shell when being acted by external force so as to accumulate reset force on the reset piece. The reset piece can release the reset force to drive the sliding piece to reset. The ultrasonic transducer is connected with the sliding piece and can drive the sliding piece to vibrate at a high frequency. The sliding part of the vibration component can be abutted against the reaction cup filled with the magnetic particle reagent, and the ultrasonic transducer works at the moment and can transmit energy to the reaction cup through the sliding part, so that the reaction cup vibrates at high frequency and uniformly mixes the magnetic particle reagent. Because the slider is at the in-process of butt reaction cup, reset the piece and save reset force, so the slider butt reaction cup is more stable, and the difficult liquid that splashes of magnetic particle reagent that the reaction cup is difficult for dropping and cup.

Description

Vibration subassembly and mixing device

Technical Field

The utility model relates to an external diagnostic equipment technical field especially relates to a vibration subassembly and mixing device.

Background

The magnetic particles are colloidal composite materials which can be uniformly dispersed in base liquid, and have the characteristics of superparamagnetism, modifiable functional groups and the like. Therefore, antigens/antibodies, enzymes, nucleic acids/oligonucleotides, small molecule drugs, etc. can be immobilized on their surfaces. At present, magnetic particle reagents are generally mixed by mechanical oscillation, specifically, the magnetic particle reagents are firstly placed in a reaction cup, and then the reaction cup is grabbed by a manipulator and placed in a mixer for oscillation and mixing. In the process of uniformly mixing, the reaction cup is easy to drop or splash, and the loss of materials is caused.

SUMMERY OF THE UTILITY MODEL

Accordingly, it is necessary to provide a vibration unit and a kneading apparatus for solving the problem that a magnetic fine particle reagent is likely to fall or splash during the process of shaking and kneading.

The utility model provides a vibration subassembly for vibration mixing magnetic particle reagent, the vibration subassembly includes:

a housing;

the sliding piece is connected with the shell in a sliding manner;

the resetting piece is connected to the sliding piece and the shell, and the sliding piece can slide relative to the shell when being acted by external force so as to accumulate resetting force by the resetting piece; the resetting piece can release the resetting force to drive the sliding piece to reset;

and the ultrasonic transducer is connected to the sliding piece and can drive the sliding piece to vibrate at a high frequency.

The sliding part of the vibration component can be abutted against the reaction cup filled with the magnetic particle reagent, and the ultrasonic transducer works at the moment and can transmit energy to the reaction cup through the sliding part, so that the reaction cup vibrates at high frequency and uniformly mixes the magnetic particle reagent. Because the slider is at the in-process of butt reaction cup, reset the piece and save the power that resets, so slider butt reaction cup is more stable, and the difficult liquid that spatters of the difficult drop of reaction cup and the magnetic particle reagent in the cup.

In one embodiment, the sliding part comprises a sliding block, a sliding cavity is arranged in the shell, and the outer wall of the sliding block is in sliding fit with the cavity wall of the sliding cavity, so that the sliding block can slide back and forth in the sliding cavity.

In one embodiment, the slider further comprises a horn, one end of the slider is connected to the horn, and the opposite end of the slider is connected to the ultrasonic transducer.

In one embodiment, the radial gears at the opposite ends of the horn are larger than the radial dimension of the middle portion.

In one embodiment, the end of the amplitude transformer, which faces away from the slide block, is a continuous plane.

In one embodiment, the resetting piece is an elastic piece, and the resetting force is an elastic force; or, the piece that resets includes two magnetism and inhales the piece, one of them magnetism is inhaled the piece and is located the casing, another magnetism is inhaled the piece and is located the slider, the power that resets is two magnetism is inhaled the magnetic force that produces between the piece.

In one embodiment, the vibration assembly further includes a connecting member and a limiting member, one end of the connecting member is connected to the sliding member or the ultrasonic transducer, the other end of the connecting member is connected to the limiting member, and the housing is capable of limiting the limiting member.

In one embodiment, the connecting piece is provided with a clamping groove along the circumferential direction, the limiting part is a clamp spring, the clamp spring is clamped in the clamping groove, and the shell can abut against the clamp spring.

The utility model also provides a mixing device, include lifting unit, reaction cup and as above-mentioned vibration subassembly, the vibration subassembly is connected lifting unit, the reaction cup is used for holding magnetic particle reagent, lifting unit can drive the slider supports and presses the reaction cup, so that ultrasonic transducer passes through the slider is right reaction cup high-frequency vibration.

In one embodiment, the blending device further comprises a turntable and a rotating assembly, wherein the turntable is provided with a plurality of reaction cups, and the rotating assembly can drive the turntable to rotate so that each reaction cup can be vibrated by the vibrating assembly at high frequency.

Drawings

Fig. 1 is a schematic structural view of a viewing angle of the blending device of the present invention;

fig. 2 is a schematic structural view of another visual angle of the blending device of the present invention;

fig. 3 is a schematic structural view of a viewing angle of the vibration assembly of the present invention;

fig. 4 is a schematic structural view of another view angle of the vibration assembly of the present invention;

fig. 5 is an exploded view of the vibration module of the present invention;

fig. 6 is a schematic structural diagram of the housing of the present invention.

In the drawings, the components represented by the respective reference numerals are listed below:

100. a blending device;

1. a blending component; 11. a machine platform; 12. a rotating assembly; 121. a rotation motor; 122. a driving wheel; 123. a first drive belt; 124. a first driven wheel; 125. a second driven wheel; 126. a second belt; 127. a third driven wheel; 13. a lifting assembly; 131. a drive motor; 132. a rotating shaft; 133. a rotating member; 134. a driven member; 135. a lifting guide rail; 136. a lifting frame; 14. a turntable;

2. a vibrating assembly; 21. a housing; 211. a sliding cavity; 212. a through hole; 213. a connecting flange; 214. mounting holes; 22. a slider; 221. a slider; 222. an amplitude transformer; 23. an ultrasonic transducer; 24. a reset member; 25. a connecting member; 251. fixing the disc; 252. a connecting rod; 2521. a card slot; 26. a limiting member; 261. a snap ring; 262. a shaft sleeve; 2621. a hollow bore; 2622. positioning seats; 2623. limiting the edge;

3. a reaction cup.

Detailed Description

In order to make the above objects, features and advantages of the present invention more comprehensible, embodiments of the present invention are described in detail below with reference to the accompanying drawings. It is apparent that the specific details set forth in the following description are merely exemplary of the invention, which can be practiced in many other embodiments that depart from the specific details disclosed herein. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without creative efforts all belong to the protection scope of the present invention.

It will be understood that when an element is referred to as being "secured to" another element, it can be directly on the other element or intervening elements may also be present. When an element is referred to as being "connected" to another element, it can be directly connected to the other element or intervening elements may also be present. The terms "vertical," "horizontal," "left," "right," and the like as used herein are for illustrative purposes only and do not represent the only embodiments.

Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs. The terminology used in the description of the invention herein is for the purpose of describing particular embodiments only and is not intended to be limiting of the invention.

Referring to fig. 1 and 2, the present invention provides a mixing device 100, wherein the mixing device 100 is used for vibrating a reaction cup 3 containing magnetic particle reagents at high frequency to uniformly mix the magnetic particle reagents in the reaction cup 3. In the process of mixing uniformly, the magnetic particle reagent is not easy to spill out of the reaction cup 3 to waste materials, and the reaction cup 3 is not easy to drop.

The blending device 100 comprises a blending component 1 and a vibration component 2, wherein the vibration component 2 is arranged on the blending component 1. The uniform mixing component 1 is used for fixing the reaction cup 3, and the vibration component 2 is used for vibrating the reaction cup 3 at high frequency, so that the magnetic particle reagent in the reaction cup 3 is uniformly mixed.

The blending component 1 comprises a machine table 11, a rotating component 12, a lifting component 13 and a turntable 14, wherein the rotating component 12, the lifting component 13 and the turntable 14 are all arranged on the machine table 11.

A plurality of reaction cups 3 are arranged on the rotary table 14 along the circumferential direction, magnetic particle reagents can be poured into each reaction cup 3, and the rotary table 14 can rotate relative to the machine table 11, so that each reaction cup 3 is vibrated by the vibration component 2 at high frequency one by one, and the magnetic particle reagents in each reaction cup 3 are uniformly mixed.

The rotating assembly 12 is connected with the rotating disc 14, and the rotating assembly 12 is used for driving the rotating disc 14 to rotate, so that each reaction cup 3 on the rotating disc 14 is vibrated at high frequency by the vibrating assembly 2 one by one.

With continued reference to fig. 1, rotating assembly 12 includes a rotating motor 121, a drive pulley 122, a first drive belt 123, a first driven pulley 124, a second driven pulley 125, a second drive belt 126, and a third driven pulley 127. The rotation motor 121 is connected to a driving wheel 122, the driving wheel 122 is connected to a first driven wheel 124 through a first transmission belt 123, the first driven wheel 124 is coaxially connected to a second driven wheel 125, and the second driven wheel 125 is connected to a third driven wheel 127 through a second transmission belt 126.

When the rotation motor 121 is powered on, the rotation motor 121 can drive the driving wheel 122 to rotate, the driving wheel 122 drives the first driven wheel 124 to rotate through the first transmission belt 123, the first driven wheel 124 drives the second driven wheel 125 to rotate, and the second driven wheel 125 drives the third driven wheel 127 to rotate through the second transmission belt 126. The third driven wheel 127 is coaxially connected with the rotary disc 14, so that the third driven wheel 127 can drive the rotary disc 14 to rotate when rotating, so that each reaction cup 3 positioned on the rotary disc 14 is vibrated at high frequency by the vibration assembly 2 one by one.

Referring to fig. 2, the lifting assembly 13 includes a driving motor 131, a rotating shaft 132, a rotating member 133, a driven member 134, a lifting guide rail 135 and a lifting frame 136, the driving motor 131 is connected to the rotating shaft 132, the rotating shaft 132 is fixedly connected to the rotating member 133, the rotating member 133 is rotatably connected to the driven member 134, the lifting frame 136 is slidably connected to the lifting guide rail 135, one end of the lifting frame 136 is rotatably connected to the driven member 134, and the other end of the lifting frame 136 is connected to the vibrating assembly 2.

When the driving motor 131 is in a working state, the rotating shaft 132 can be driven to rotate, the rotating shaft 132 drives the rotating member 133 to rotate, the rotating member 133 drives the driven member 134 to reciprocate up and down in the rotating process, and the driven member 134 drives the lifting frame 136 to reciprocate up and down on the lifting guide rail 135, so that the lifting frame 136 drives the vibration assembly 2 to slide up and down back and forth, and the position of the vibration assembly 2 in the vertical direction is adjusted.

When driving motor 131 drives crane 136 and descends, vibration subassembly 2 can support the top of pressing reaction cup 3 downwards, and vibration subassembly 2 is with high-frequency vibration's energy transfer to reaction cup 3 again, orders about reaction cup 3 high-frequency vibration, the magnetic particle reagent in the mixing reaction cup 3. After the mixing operation of one reaction cup 3 is completed, the rotating motor 121 is started to drive the rotating disc 14 to rotate, so that the next reaction cup 3 rotates to a position right below the vibrating component 2, and then the driving motor 131 is controlled to drive the vibrating component 2 to descend to vibrate the new reaction cup 3 at a high frequency. And the same process is repeated to complete the mixing of all the reaction cups 3 on the rotating disc 14.

Referring to fig. 3, 4 and 5, a schematic view of the vibration assembly 2 is shown. As shown in fig. 5, the vibration assembly 2 includes a housing 21, a sliding member 22, an ultrasonic transducer 23, a reset member 24, a connecting member 25 and a limiting member 26, the sliding member 22 is slidably connected to the housing 21, the ultrasonic transducer 23 is connected to the sliding member 22, the reset member 24 is connected to the sliding member 22 and the housing 21, and the connecting member 25 is connected to the ultrasonic transducer 23 and the limiting member 26.

Referring to fig. 6, a sliding cavity 211 is formed in the housing 21, and the sliding cavity 211 is a cylindrical cavity. It is understood that in other embodiments, the shape of the sliding cavity 211 may also be other shapes, such as a rectangular parallelepiped shape, etc., and is not limited herein.

The sliding cavity 211 is used for slidably connecting the sliding member 22, so that the sliding member 22 can stably slide back and forth along the sliding cavity 211.

The top of the housing 21 is opened with a through hole 212, and the through hole 212 is communicated with the sliding cavity 211 and the outside of the housing 21. The through hole 212 is for the position-limiting element 26 to pass through, so that the housing 21 can limit the position of the position-limiting element 26.

The outer side wall of the casing 21 has two connecting flanges 213 disposed oppositely, each connecting flange 213 has a mounting hole 214, the mounting hole 214 can be penetrated by a screw, and the screw is threaded on the lifting member 132 of the mixing assembly 1 to mount the whole vibrating assembly 2 on the lifting member 132. It is understood that in other embodiments, the housing 21 and the lifting member 132 may be connected in other manners, such as an integral structure, a snap-fit manner, etc., which are not limited herein.

Slider 22 includes a slider 221 and a horn 222, slider 221 and horn 222 are integrally formed, and in other embodiments, slider 221 and horn 222 can be connected by other means, such as a threaded connection, a snap connection, etc., without limitation.

The slide block 221 is used for connecting with the ultrasonic transducer 23, and the amplitude transformer 222 is used for pressing against the reaction cup 3. The slider 221 and the amplitude transformer 222 in an integrally formed structure can be tightly connected, the ultrasonic transducer 23 transmits energy to the slider 221, the slider 221 can be substantially and completely transmitted to the amplitude transformer 222, and the loss of the energy transmitted in the middle is small.

The slider 221 has a pie shape, and the shape of the slider 221 substantially corresponds to the cross-sectional shape of the sliding cavity 211 inside the housing 21, and it can be understood that the cross-sectional diameter of the sliding cavity 211 substantially corresponds to the diameter of the slider 221, so that the slider 221 (the slider 22) can stably slide back and forth relative to the housing 21 in the sliding cavity 211.

The side of the slider 221 facing away from the horn 222 is used for connecting the ultrasonic transducer 23 so as to receive the high-frequency vibration energy of the ultrasonic transducer 23.

One end of horn 222 is connected to slider 221 so that horn 222 can follow the back and forth sliding movement of slider 221 as it slides back and forth.

The other end of the amplitude transformer 222 is used for pressing against the top of the reaction cup 3, and the amplitude transformer 222 receives the energy transmitted by the sliding block 221 and then vibrates in high frequency, so that the amplitude transformer 222 transmits the energy to the reaction cup 3, and drives the reaction cup 3 to vibrate in high frequency, so that the magnetic particle reagent in the reaction cup 3 is uniformly mixed.

The radial dimension of the two opposite ends of the horn 222 is larger than the radial dimension of the middle part, so that the ends of the horn 222 can not only fully receive the energy transmitted by the slide block 221, but also fully transmit the energy to the reaction cup 3, and the energy loss is reduced as much as possible in the transmission process. The volume of the central portion of horn 222 is small, which reduces the loss of energy transferred from one end to the other.

The end surface of the amplitude transformer 222 facing away from the slider 221 is a continuous plane, so that when the end surface of the amplitude transformer 222 is pressed against the reaction cup 3, the end surface can completely block the opening of the reaction cup 3, and the waste of materials caused by the splashing of the magnetic particle reagent in the reaction cup 3 in the vibration process is avoided.

The ultrasonic transducer 23 is prior art, and its specific structure is not described in detail herein. The ultrasonic transducer 23 is used for emitting energy of high-frequency vibration and transmitting the energy to the sliding block 221 connected with the ultrasonic transducer, the sliding block 221 transmits the energy to the amplitude transformer 222, and the amplitude transformer 222 transmits the energy to the reaction cup 3.

The reset element 24 is an elastic element, and two ends of the elastic element are respectively connected to the end surface of the slider 221 and the bottom of the sliding cavity 211 in the housing 21. When the amplitude transformer 222 presses against the reaction cup 3, the position of the reaction cup 3 does not change, so the reaction cup 3 applies a reaction force to the amplitude transformer 222, the reaction force drives the elastic member to be compressed, and the elastic member accumulates elastic force.

Through the action of the elastic force, the amplitude transformer 222 is pressed against the top of the reaction cup 3 more tightly, and relative sliding between the amplitude transformer 222 and the reaction cup 3 is not easy to occur. In addition, the reaction cup 3 is not easily damaged by the rigid force of the horn 222, and the reaction cup 3 can be protected.

The connecting member 25 includes a fixing plate 251 and a connecting rod 252, and the fixing plate 251 and the connecting rod 252 are integrally formed.

One end of the fixed disk 251 is connected to the ultrasonic transducer 23, and the other end of the fixed disk 251 is connected to the connecting rod 252.

One end of the connecting rod 252 is connected to the fixing plate 251, and the other end of the connecting rod 252 is circumferentially provided with a slot 2521.

The limiting member 26 includes a clamp spring 261 and a shaft sleeve 262, and the clamp spring 261 is clamped in a clamping groove 2521 formed in the connecting rod 252.

The shaft sleeve 262 has a hollow hole 2621 extending through the thickness direction, and the hollow hole 2621 allows the connecting rod 252 to pass through. The shaft sleeve 262 includes a limit edge 2623 and a positioning seat 2622, and the limit edge 2623 and the positioning seat 2622 are an integrally formed structure.

The positioning seat 2622 is inserted into the through hole 212 formed in the top of the housing 21 and is in interference fit with the through hole to position the shaft sleeve 262.

The limiting edge 2623 abuts against the top of the housing 21, and in the installation process, after the end of the connecting rod 252 opposite to the fixed disk 251 penetrates through the through hole 212 at the top of the housing 21, the shaft sleeve 262 is penetrated through, and finally the clamp spring 261 is clamped in the clamping groove 2521.

The radial dimension of the circlip 261 is greater than the radial dimension of the hollow hole 2621 of the sleeve 262, so the limiting edge 2623 can abut the circlip 261 to limit the circlip 261.

When the amplitude transformer 222 presses against the reaction cup 3, the reaction force applied by the reaction cup 3 to the amplitude transformer 222 drives the sliding block 221 to slide towards the elastic member, and presses against the elastic member to accumulate the elastic force. At this time, the connecting rod 252 moves relative to the housing 21 to drive the circlip 261 to disengage from the limit edge 2623 of the sleeve 262.

When the amplitude transformer 222 is separated from the reaction cup 3, the elastic member releases the elastic force to drive the sliding block 221 to slide back to the elastic force relative to the housing 21. The slider 221 drives the connecting rod 252 to slide toward the amplitude transformer 222 until the clamp spring 261 abuts against the limit edge 2623 of the sleeve 262. The sliding member 22, the ultrasonic transducer 23, the restoring member 24 and the connecting member 25 are prevented from sliding out of the sliding cavity 211 by the limiting action of the sleeve 262.

In an alternative embodiment, the above-mentioned elastic member can be replaced by two magnetic members, wherein one magnetic member is installed at the bottom of the sliding cavity 211, and the other magnetic member is installed on the fixing disk 251. When the slider 22 slides toward the cavity bottom of the slide cavity 211, the two magnetic attracting members accumulate a magnetic force. When the sliding member 22 is not acted upon by an external force, the two magnetic attraction members can release the magnetic force to drive the sliding member 22 to return.

The technical features of the embodiments described above may be arbitrarily combined, and for the sake of brevity, all possible combinations of the technical features in the embodiments described above are not described, but should be considered as being within the scope of the present specification as long as there is no contradiction between the combinations of the technical features.

The above-mentioned embodiments only represent some embodiments of the present invention, and the description thereof is specific and detailed, but not to be construed as limiting the scope of the present invention. It should be noted that, for those skilled in the art, without departing from the spirit of the present invention, several changes, substitutions and improvements can be made, and all of them should be covered by the protection scope of the present invention. Therefore, the protection scope of the present invention should be subject to the claims.

Claims

1. The utility model provides a vibration subassembly for vibrate mixing magnetic particle reagent, its characterized in that, the vibration subassembly includes:

a housing;

the sliding piece is connected with the shell in a sliding manner;

the resetting piece is connected to the sliding piece and the shell, and the sliding piece can slide relative to the shell when being acted by external force so as to accumulate resetting force on the resetting piece; the resetting piece can release the resetting force to drive the sliding piece to reset;

2. The vibration assembly of claim 1 wherein the sliding member comprises a sliding block, the housing has a sliding cavity therein, and an outer wall of the sliding block is slidably fitted with a wall of the sliding cavity so that the sliding block can slide back and forth in the sliding cavity.

3. The vibratory assembly of claim 2 wherein the slider further comprises a horn, one end of the slider being connected to the horn and an opposite end of the slider being connected to the ultrasonic transducer.

4. The vibratory assembly of claim 3 wherein the radial gears at opposite ends of the horn are larger than the radial dimension of the central portion.

5. The vibration assembly of claim 3 wherein the end of the horn facing away from the slider is a continuous flat surface.

6. The vibration assembly of claim 1 wherein the restoring member is an elastic member and the restoring force is an elastic force; or, the piece that resets includes two magnetism and inhales the piece, one of them magnetism is inhaled the piece and is located the casing, another magnetism is inhaled the piece and is located the slider, the power that resets is two magnetism is inhaled the magnetic force that produces between the piece.

7. The vibration assembly of claim 1, further comprising a connecting member and a limiting member, wherein one end of the connecting member is connected to the sliding member or the ultrasonic transducer, the other end of the connecting member is connected to the limiting member, and the housing can limit the limiting member.

8. The vibration assembly according to claim 7, wherein the connecting member is provided with a clamping groove along a circumferential direction thereof, the limiting member is a clamp spring, the clamp spring is clamped in the clamping groove, and the housing can abut against the clamp spring.

9. A blending device, characterized by including lifting unit, reaction cup and according to any claim 1-8 vibration subassembly, vibration subassembly is connected lifting unit, reaction cup is used for holding magnetic particle reagent, lifting unit can drive the slider supports and presses reaction cup, so that ultrasonic transducer passes through the slider is right reaction cup high-frequency vibration.

10. The blending device according to claim 9, further comprising a turntable and a rotating assembly, wherein the turntable is provided with a plurality of reaction cups, and the rotating assembly can drive the turntable to rotate, so that each reaction cup can be vibrated at high frequency by the vibrating assembly.