CN215302625U - Liquid-based cell preservation bottle - Google Patents
Liquid-based cell preservation bottle Download PDFInfo
- Publication number
- CN215302625U CN215302625U CN202121975398.2U CN202121975398U CN215302625U CN 215302625 U CN215302625 U CN 215302625U CN 202121975398 U CN202121975398 U CN 202121975398U CN 215302625 U CN215302625 U CN 215302625U
- Authority
- CN
- China
- Prior art keywords
- bottle
- liquid
- filter
- cartridge
- based cell
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Images
Landscapes
- Sampling And Sample Adjustment (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
Abstract
The utility model discloses a liquid-based cell preservation bottle, which comprises a bottle body and a bottle cap, wherein the bottle cap covers an opening at the upper end of the bottle body, a filter cylinder is arranged in the bottle body, the lower end of the filter cylinder is closed, a liquid suction opening for the liquid suction pipe to enter and exit is formed in the upper end of the filter cylinder, a gap for placing a collection brush is formed between the side wall of the filter cylinder and the inner wall of the bottle body, and a plurality of filter holes communicated with the inner space and the outer space of the filter cylinder are formed in the side wall of the filter cylinder and used for preventing interference components in the gap from entering the filter cylinder. Need not pour liquid in the sampling process, also need not the manual work and take out the collection brush, reduce operator intensity of labour, can keep apart the interference composition, reduce sample pretreatment step, promote the film-making efficiency, promoted the preliminary treatment effect to the cell, avoid liquid to spill, promote the security, more be fit for the direct sample of absorbing of automation equipment puncture bottle lid.
Description
Technical Field
The utility model relates to the field of medical equipment, in particular to a liquid-based cell preservation bottle.
Background
Liquid-based cell preservation is called TCT for short, and is a cytology slide making technology. Compared with the traditional smear, the liquid-based cell preservation is realized by preserving the specimen with the preservation solution, and then the specimen is treated with a series of early-stage technologies to remove impurity components in the specimen, so that a thin layer with clear observation under a mirror is manufactured, a reader can observe the specimen more easily, the diagnosis accuracy and sensitivity of the smear are obviously improved compared with the traditional smear, and the smear can effectively collect and preserve cervical exfoliated cells, and is a key technology for screening cervical cancer. The cell preservation solution has the functions of maintaining cell morphology, dispersing mucus, treating red blood cells, etc.
When clinical department of hospital carries out cervical cell sampling, generally be with cervical collection brush sample back, abandon the preservation liquid bottle with gathering the brush head, the artifical brush that will gather after the oscillation mixing takes out, and the manipulator on through manual work or equipment is again with the preservative solution suction film-making.
However, in the above manner, the operation intensity of a clinician is increased in the taking-out process of the collection brush, potential safety hazards are caused by the fact that the storage liquid is scattered outside the body in the taking-out process, and cells cannot be sufficiently eluted after the collection brush is taken out, and a part of the cells are lost.
Therefore, how to provide a stable and efficient liquid-based cell preservation bottle is a technical problem to be solved by those skilled in the art.
SUMMERY OF THE UTILITY MODEL
The utility model aims to provide a liquid-based cell preservation bottle, cells are collected and then placed into a bottle body, a collection brush does not need to be taken out manually, the labor intensity of an operator is reduced, liquid is prevented from being spilled, interference components can be isolated by sampling in a filter cylinder, the pretreatment effect on the cells is improved, and the liquid-based cell preservation bottle is more suitable for being used for directly sucking the samples by puncturing a bottle cap by automatic equipment.
In order to solve the technical problems, the utility model provides a liquid-based cell preservation bottle, which comprises a bottle body and a bottle cap covering an opening at the upper end of the bottle body, wherein a filter cylinder is installed in the bottle body, the lower end of the filter cylinder is closed, a liquid suction opening for a liquid suction pipe to enter and exit is formed at the upper end of the filter cylinder, a gap for placing a collection brush is formed between the side wall of the filter cylinder and the inner wall of the bottle body, and a plurality of filter holes communicated with the inner space and the outer space of the filter cylinder are formed in the side wall of the filter cylinder and used for preventing interference components in the gap from entering the filter cylinder.
Preferably, the liquid suction opening is flush with the opening at the upper end of the bottle body in height, and the liquid suction opening is abutted against the lower surface of the end surface of the bottle cap.
Preferably, a downward convex annular convex edge is arranged below the end face of the bottle cap, the bottle cap covers the opening at the upper end of the bottle body, and the annular convex edge extends into the liquid suction opening and is in interference fit with the liquid suction opening.
Preferably, the bottle body and the filter cartridge are of a cylindrical structure coaxially arranged, and the diameter of the bottle body is larger than that of the filter cartridge.
Preferably, the lower end of the filter cylinder is tightly attached to the bottom surface of the bottle body, and the filter cylinder and the bottle body are subjected to injection molding or bonding.
Preferably, the lower end of the filter cylinder is of a downward-pointed conical structure.
Preferably, the bottom surface of the bottle body is provided with a slot matched with the shape of the lower end of the filter cartridge, and the lower end of the filter cartridge is embedded into the slot.
Preferably, the filter cartridge is a nylon cartridge, and the size of the filter holes arranged in an array is 50 to 200 meshes.
Preferably, the thickness of the end surface of the bottle cap becomes thinner gradually from the edge to the center.
Preferably, the end face of the bottle cap is provided with a radial groove, the center of the radial groove is intersected at the center of the end face of the bottle cap and is superposed, and the thickness of the end face at the radial groove is smaller than that of the rest part of the end face of the bottle cap.
The utility model provides a liquid-based cell preservation bottle, which comprises a bottle body and a bottle cap, wherein the bottle cap covers an opening at the upper end of the bottle body, a filter cylinder is installed in the bottle body, the lower end of the filter cylinder is closed, a liquid suction opening for a liquid suction pipe to enter and exit is formed in the upper end of the filter cylinder, a gap for placing a collection brush is formed between the side wall of the filter cylinder and the inner wall of the bottle body, and a plurality of filter holes communicated with the inner space and the outer space of the filter cylinder are formed in the side wall of the filter cylinder and used for preventing interference components in the gap from entering the filter cylinder.
In the above-mentioned structure, the cell preservation liquid has been held in the bottle, and cartridge filter inside is the sampling area, and the region is for placing in the clearance area between the outer and bottle inner wall of cartridge filter lateral wall. In the course of the work, gather the brush sample back, put into by bottle upper end opening with the collection brush and place the district in, cover bottle lid closed bottle upper end opening and the imbibition opening of cartridge filter upper end, it mixes to vibrate the bottle, can freely pass through the filtration pore on the cartridge filter after the cell on the collection brush mixes with cell preservation liquid, the cell gets into the sampling area, the separation disturbs the composition simultaneously and gets into the sampling area, make to disturb the composition stop in placing the district, then pipette puncture bottle lid, get into by the imbibition opening of cartridge filter upper end, absorb the sample in order to carry out follow-up operation.
Need not pour liquid in the sampling process, also need not the manual work and take out the collection brush, reduce operator intensity of labour, can keep apart the interference composition, reduce sample pretreatment step, promote the film-making efficiency, promoted the preliminary treatment effect to the cell, avoid liquid to spill, promote the security, more be fit for the direct sample of absorbing of automation equipment puncture bottle lid.
Drawings
FIG. 1 is a front sectional view of a first embodiment of a liquid-based cell storage bottle according to the present invention;
FIG. 2 is a schematic structural diagram of a filter cartridge in a second embodiment of the liquid-based cell preservation bottle of the present invention;
FIG. 3 is a schematic structural diagram of a filter cartridge in a third embodiment of the liquid-based cell preservation bottle provided by the present invention;
FIG. 4 is a schematic front view of a bottle cap according to an embodiment of the present invention;
FIG. 5 is a schematic top view of a cap of one embodiment of a liquid-based cell preservation vial according to the present invention;
fig. 6 is a schematic bottom view of a bottle cap according to an embodiment of the liquid-based cell preservation bottle provided by the present invention.
Detailed Description
The core of the utility model is to provide a liquid-based cell preservation bottle, cells are placed into a bottle body after being collected, a collection brush does not need to be taken out manually, the labor intensity of an operator is reduced, liquid is prevented from being spilled, interference components can be isolated by sampling in a filter cylinder, the pretreatment effect on the cells is improved, and the liquid-based cell preservation bottle is more suitable for automatic equipment to puncture a bottle cap to directly absorb a sample.
In order that those skilled in the art will better understand the disclosure, the utility model will be described in further detail with reference to the accompanying drawings and specific embodiments.
Referring to fig. 1, fig. 1 is a front sectional view of a liquid-based cell preservation bottle according to a first embodiment of the present invention.
The embodiment of the utility model provides a liquid-based cell preservation bottle, which comprises a bottle body 1, a bottle cap 2 and a filter cylinder 3, wherein the lower end of the bottle body 1 is a bottom surface, the upper end of the bottle body is an opening, the bottle cap 2 covers the opening at the upper end of the bottle body 1, the bottle cap 2 comprises an end surface and a lower edge arranged below the edge of the end surface, the lower edge wraps the upper end of the bottle body 1, external threads can be arranged at the upper end of the outer wall of the bottle body 1, internal threads are arranged on the inner wall of the lower edge, the internal threads are connected with the internal threads through threads to seal the opening at the upper end of the bottle body 1, meanwhile, a limiting ring is arranged at the position, close to the upper end, of the outer wall of the bottle body 1 and used for supporting the bottle body 1 when the bottle body 1 is placed in a hole of a support, and vertical anti-slip threads are arranged on the pressing outer wall of the bottle cap 2.
In the course of the work, gather brush 4 sample backs, put into by 1 upper end opening of bottle with collection brush 4 and place the district in, cover the imbibition opening of 1 upper end opening of 2 closed bottle bodies of bottle and the 3 upper ends of cartridge filter, it mixes to vibrate bottle 1, can freely pass through the filtration pore on the cartridge filter 3 after the cell on the collection brush 4 mixes with the cell preservation liquid, the cell gets into the sampling area, the separation disturbs the composition simultaneously and gets into the sampling area, make to disturb the composition and stop in placing the district, then pipette puncture bottle lid 2, get into by the imbibition opening of the 3 upper ends of cartridge filter, absorb the sample in order to carry out follow-up operation.
Need not pour liquid in the sampling process, also need not the manual work and take out the collection brush, reduce operator intensity of labour, can keep apart the interference composition, reduce sample pretreatment step, promote the film-making efficiency, promoted the preliminary treatment effect to the cell, avoid liquid to spill, promote the security, more be fit for the direct sample of absorbing of automation equipment puncture bottle lid, need not artifical screw cap.
Specifically, in order to guarantee that isolated placing area and sampling area, imbibition opening and the high parallel and level of bottle 1 upper end open-ended, the imbibition opening offsets below the 2 terminal surfaces of bottle lid, makes bottle lid 2 can seal the imbibition opening simultaneously.
Further, in order to effectively seal the liquid suction opening, a downward convex ring-shaped convex edge 21 is arranged below the end face of the bottle cap 2, the shape of the ring-shaped convex edge 21 is matched with that of the liquid suction opening, after the bottle cap 2 covers the opening at the upper end of the bottle body 1, the ring-shaped convex edge 21 extends into the liquid suction opening, and the liquid suction opening is completely sealed by interference fit of the ring-shaped convex edge 21 and the liquid suction opening. The bottle 1 and the cartridge filter 3 can adopt multiple shapes, the bottle 1 and the cartridge filter 3 are the cylinder structure of coaxial setting, the diameter of the bottle 1 is greater than the diameter of the cartridge filter 3, and the bottle cap 2 is corresponding to be a round cap. Or the shape and arrangement of the components are adjusted according to the situation and are within the protection scope of the utility model.
Wherein, the lower end of the filter cartridge 3 is tightly attached to the bottom surface of the bottle body 1, and the filter cartridge and the bottom surface are injection molded or bonded. Specifically, the filter cartridge 3 may be provided with an independent bottom surface, and bonded to the bottom surface of the bottle body 1, or the filter cartridge 3 may be provided with no independent bottom surface, and the circular opening at the lower end of the filter cartridge 3 is directly bonded to the bottom surface of the bottle body 1 or integrally injection-molded.
The filter cartridge 3 can also take other shapes, please refer to fig. 2 and fig. 3, fig. 2 is a schematic structural diagram of the filter cartridge in the second embodiment of the liquid-based cell preservation bottle provided by the present invention; fig. 3 is a schematic structural diagram of a filter cartridge in a third embodiment of the liquid-based cell preservation bottle provided by the utility model.
In the second embodiment, the lower end of the filter cartridge 3 is a cone-shaped structure with a downward tip, and the bottom of the cone-shaped filter cartridge is convenient for sedimentation and enrichment of cells, so that the filter cartridge is suitable for sucking cells under the condition that the diameter of the pipette is smaller, and the bottom of the cone-shaped filter cartridge is suitable for sucking cells under the condition that the diameter of the pipette is thicker.
In the third embodiment, the bottom surface of the bottle body 1 is provided with a slot 11 matching with the shape of the lower end of the filter cartridge 3, and the lower end of the filter cartridge 3 is embedded into the slot 11. Furthermore, the bottom surface of the bottle body 1 can be a plane surface, an inverted conical surface or various bottom surfaces, and the utility model is within the protection scope.
Furthermore, the filter cartridge 3 is a nylon cartridge or made of other materials, and the size of the filter holes arranged in an array is 50 to 200 meshes, so that interference components affecting diagnosis, such as mucus, leucorrhea and the like, can be prevented from entering the sampling area.
Referring to fig. 4 to 6, fig. 4 is a schematic front view of a bottle cap of an embodiment of a liquid-based cell preservation bottle of the present invention; FIG. 5 is a schematic top view of a cap of one embodiment of a liquid-based cell preservation vial according to the present invention; fig. 6 is a schematic bottom view of a bottle cap according to an embodiment of the liquid-based cell preservation bottle provided by the present invention.
On the basis of the liquid-based cell preservation bottle provided by each embodiment, the thickness of the end face of the bottle cap 2 is gradually reduced from the edge to the center, so that the pipette can conveniently puncture. Further, a radial groove 22 is formed in the end face of the bottle cap 2, the centers of the radial grooves 22 are intersected and positioned at the center of the end face of the bottle cap 2 to be overlapped, namely a plurality of linear grooves are formed in the upper face and/or the lower face of the end face of the bottle cap 2, each linear groove passes through the center of the end face of the bottle cap 2 in a radial mode, the radial grooves 22 are arranged in a staggered mode to be radial, meanwhile, the radial grooves 22 cannot penetrate through the end face of the bottle cap 2, the end face of the bottle cap 2 before the pipette punctures is a complete closed face, and the thickness of the position, where the radial groove 22 is formed, of the end face of the bottle cap 2 is smaller than the thickness of the rest portion of the end face of the bottle cap 2, so that the radial groove 22 is easier to puncture, and preferably, the radial groove 22 can be arranged in the annular convex edge 21. Specifically, the radial groove 22 may have a radial shape with six vertexes, or may have various shapes such as a cross shape.
In the process of puncturing the pipette, the pipette is aligned with the radial groove 22 and pressed downwards, the radial groove 22 cracks at first, the broken part of the end face bends downwards to form a hole in the center of the end face of the bottle cap 2, so that the pipette enters into the bottle, the pipette enters into the bottle for positioning in the above mode, and even if the pipette deviates from the center position, the radial groove 22 cracks at first to form a hole in the center.
The liquid-based cell preservation bottle provided by the utility model is described in detail above. The principles and embodiments of the present invention are explained herein using specific examples, which are presented only to assist in understanding the method and its core concepts. It should be noted that, for those skilled in the art, it is possible to make various improvements and modifications to the present invention without departing from the principle of the present invention, and those improvements and modifications also fall within the scope of the claims of the present invention.
Claims (10)
1. The utility model provides a bottle is preserved to liquid-based cell, its characterized in that, includes bottle (1) and cover bottle (2) of bottle (1) upper end open-ended, install cartridge filter (3) in bottle (1), cartridge filter (3) lower extreme is sealed, cartridge filter (3) upper end is provided with the imbibition opening that is used for the pipette business turn over, cartridge filter (3) lateral wall with be provided with the clearance that is used for placing collection brush (4) between bottle (1) inner wall, be provided with the intercommunication on cartridge filter (3) lateral wall a plurality of filtration pores of cartridge filter (3) inner and outer space, be used for the separation interference composition in the clearance gets into inside cartridge filter (3).
2. The liquid-based cell preservation bottle according to claim 1, wherein the liquid suction opening is flush with the upper opening of the bottle body (1) and abuts against the lower surface of the end surface of the bottle cap (2).
3. The liquid-based cell preservation bottle according to claim 2, wherein an annular flange (21) protruding downwards is arranged below the end face of the bottle cap (2), and after the bottle cap (2) covers the upper opening of the bottle body (1), the annular flange (21) extends into the liquid suction opening and is in interference fit with the liquid suction opening.
4. The liquid-based cell preservation bottle according to claim 3, wherein the bottle body (1) and the filter cartridge (3) are coaxially arranged in a cylindrical structure, and the diameter of the bottle body (1) is larger than that of the filter cartridge (3).
5. The liquid-based cell preservation bottle according to claim 1, wherein the lower end of the filter cartridge (3) is tightly attached to the bottom surface of the bottle body (1), and the two are injection-molded or bonded.
6. The liquid-based cell preservation bottle according to claim 1, wherein the lower end of the filter cartridge (3) is a downward-pointing conical structure.
7. The liquid-based cell preservation bottle according to claim 1, wherein the bottom surface of the bottle body (1) is provided with a slot (11) matching with the shape of the lower end of the filter cartridge (3), and the lower end of the filter cartridge (3) is embedded into the slot (11).
8. The liquid-based cell preservation bottle according to claim 1, wherein the filter cartridge (3) is a nylon cartridge, and the filter pores arranged in an array have a size of 50 to 200 meshes.
9. The liquid-based cell preservation bottle according to any one of claims 1 to 8, wherein the thickness of the end face of the bottle cap (2) is gradually reduced from the edge to the center.
10. The liquid-based cell preservation bottle according to claim 9, wherein the end face of the bottle cap (2) is provided with a radial groove (22), the centers of the radial grooves (22) meet at the center of the end face of the bottle cap (2) and coincide with each other, and the thickness of the end face at the radial groove (22) is smaller than that of the rest of the end face of the bottle cap (2).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202121975398.2U CN215302625U (en) | 2021-08-20 | 2021-08-20 | Liquid-based cell preservation bottle |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202121975398.2U CN215302625U (en) | 2021-08-20 | 2021-08-20 | Liquid-based cell preservation bottle |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN215302625U true CN215302625U (en) | 2021-12-28 |
Family
ID=79577916
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202121975398.2U Active CN215302625U (en) | 2021-08-20 | 2021-08-20 | Liquid-based cell preservation bottle |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN215302625U (en) |
-
2021
- 2021-08-20 CN CN202121975398.2U patent/CN215302625U/en active Active
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN201188066Y (en) | Ptysma-collecting device capable of storing reagent | |
| CN105122031A (en) | Medical apparatus and method for collecting biological samples | |
| WO1989001966A1 (en) | Filter units for biological sample preparation | |
| JP2021536011A (en) | Biological sample processing equipment | |
| CN215302625U (en) | Liquid-based cell preservation bottle | |
| US6629612B2 (en) | Biological filtration station | |
| CN112263862A (en) | Sample preservation liquid bottle, sample slide device and cell pretreatment method | |
| CN217438172U (en) | Cell sample draws subassembly | |
| CN215539844U (en) | Vacuum blood collection tube | |
| CN211381389U (en) | Vacuum filter tube suitable for chylemia and lipemia specimen detection | |
| CN210037309U (en) | Sample collection device and kit for detecting blood sample | |
| CN205538343U (en) | Dirt mite allergen detection device | |
| CN110643495A (en) | Cell suspension preparation facilities | |
| CN212087676U (en) | Disposable pine wood nematode collecting and separating device | |
| CN208318101U (en) | A kind of dedicated cylinder of enzyme standard liquid liquid based cell preservative | |
| CN105713828A (en) | Cell preserving fluid bottle and using method thereof | |
| CN216738334U (en) | Free DNA preservation structure | |
| CN217431741U (en) | Liquid-based cell sap filtering and storing bottle | |
| CN218879904U (en) | Antigen biological sample sampling tube | |
| CN214667729U (en) | Double-filtering quantitative biological sample collector | |
| CN217304400U (en) | Excrement sample collector | |
| CN220546975U (en) | Sample bottle | |
| CN219578161U (en) | Cervical liquid-based cell preservation bottle convenient for sample addition | |
| CN211537801U (en) | Pipettor suction head that has filtering capability | |
| CN217248997U (en) | A collection bottle for detecting cell sap sample |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| GR01 | Patent grant | ||
| GR01 | Patent grant |