CN215026147U - Refining device of gamma cyclodextrin - Google Patents
Refining device of gamma cyclodextrin Download PDFInfo
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- CN215026147U CN215026147U CN202120758212.1U CN202120758212U CN215026147U CN 215026147 U CN215026147 U CN 215026147U CN 202120758212 U CN202120758212 U CN 202120758212U CN 215026147 U CN215026147 U CN 215026147U
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Abstract
The utility model belongs to the technical field of the medicine, concretely relates to gamma cyclodextrin's refining plant. The device comprises a solvent metering tank, a solid metering tank and a drying type centrifuge, wherein an outlet pipeline of the solvent metering tank is divided into two branches, one branch is connected with an inlet of a dissolution crystallization kettle, and the other branch is connected with an inlet of the solid metering tank; drying type centrifuge includes centrifuge shell, centrifuge inner shell and filters the sack, and centrifuge inner shell bottom is not the shutoff, filters sack both sides and the laminating of centrifuge inner shell both sides, and the opening is established to filtering the sack lower extreme, corresponds the opening and establishes sealed lid, and centrifuge shell lower extreme is the toper, and the toper is equipped with the discharge gate bottom, and the leakage fluid dram is established to toper one side, and air inlet pipeline, lower extreme connection air-out pipeline are connected to the inner chamber upper end between centrifuge shell and the centrifuge inner shell, establish the pre-heater on the air inlet pipeline. The whole refining process is closed, pollution is avoided, the drying type centrifugal machine is used for centrifugal drying, the operation is simple, waste caused by the material transfer process is reduced, and the method is suitable for industrial mass production.
Description
Technical Field
The utility model belongs to the technical field of the medicine, concretely relates to gamma cyclodextrin's refining plant.
Background
The gamma-cyclodextrin has a larger cavity than the beta-cyclodextrin, so that the range of guest molecules which can be included in the cavity is wider; better water solubility, gamma-cyclodextrin solubility is 25.6g/100ml at room temperature and 25 ℃, alpha-cyclodextrin solubility is 12.7g/100ml water, beta-cyclodextrin solubility is only 1.88g/100ml water. The application prospect is wider than that of beta-cyclodextrin, but the production scale is smaller, so the price is higher, and the popularization of the application is limited.
The gamma cyclodextrin is generally refined by recrystallization, and at present, no special refining device is provided for the gamma cyclodextrin. The refining process has the following problems:
1. in the process of transferring the crude gamma cyclodextrin product to a crystallization kettle, a part of the crude product is adhered to a container, so that waste is caused;
2. after the crystallization is finished, a centrifugal machine is mostly adopted, and an airflow dryer is used for centrifugal drying. The material is difficult to transfer, and the material is easy to cause pollution loss, so that the method is not suitable for industrial mass production.
SUMMERY OF THE UTILITY MODEL
The utility model aims at providing a gamma cyclodextrin's refining plant, simple structure, reasonable in design, the whole airtight of refining process avoids polluting, adopts stoving formula centrifuge to accomplish centrifugal drying process, and easy operation reduces the waste that the material transfer process caused, is fit for the industrialization mass production.
In order to realize the above purpose, the technical scheme of the utility model is as follows:
the refining device of the gamma cyclodextrin comprises a solvent metering tank, a solid metering tank and a drying type centrifuge, wherein an outlet pipeline of the solvent metering tank is divided into two branches, one branch is connected with an inlet of a dissolution crystallization kettle, and the other branch is connected with an inlet of the solid metering tank;
drying type centrifuge include centrifuge shell, centrifuge inner shell and filter the sack, centrifuge inner shell bottom is not the shutoff, filter the sack both sides and laminate with centrifuge inner shell both sides, filter the sack lower extreme and establish the opening, correspond the opening and establish sealed lid, centrifuge shell lower extreme is the toper, the toper is equipped with the discharge gate bottom, the leakage fluid dram is established to toper one side, the air inlet pipeline is connected to the inner chamber upper end between centrifuge shell and the centrifuge inner shell, establish the pre-heater on the air inlet pipeline, the air-out pipeline is connected to the inner chamber lower extreme between centrifuge shell and the centrifuge inner shell.
Wherein:
preferably, the solvent metering tank is connected with a nitrogen input pipeline, and the nitrogen protection reduces the influence of air on the materials.
Preferably, a spray head is arranged inside the solid metering tank, and an outlet pipeline of the solvent metering tank is connected with an inlet end of the spray head and is used for washing the materials adhered to the inner wall of the solid metering tank.
Preferably, round holes are uniformly distributed on the side wall of the inner shell of the centrifugal machine and are used for the inlet and outlet of hot air in the centrifugal dehydration and drying processes.
Preferably, the liquid discharge port is connected with an inlet of the dissolution crystallization kettle through a pipeline, so that discharged liquid is recycled, the material utilization rate is increased, and the loss is reduced.
Preferably, the sealing cover is formed by splicing two semicircular plates and is convenient to open and close.
The working principle and the process are as follows:
during operation, the crude gamma-cyclodextrin product and the solvent are respectively added into the solid metering tank and the solvent metering tank, the valve of the solid metering tank is opened to add the material into the dissolution crystallization kettle, the solvent metering tank is opened to the valve of the solid metering tank and the valve connected with the dissolution crystallization kettle, and the feeding valve is closed after all the materials are added and washed clean. After dissolving and crystallizing, the mixture is pumped into a drying centrifuge through a kettle bottom pipeline. And discharging the centrifugal filtrate through a liquid outlet at one side, and recycling the centrifugal filtrate to the dissolution crystallization kettle. Hot air is fed through an air inlet pipeline, and the centrifuged material is dried by the hot air in a filter cloth bag to finally obtain a product with high purity, low moisture and uniform particle size. And opening the discharge port and the sealing cover at the bottom of the filtering cloth bag to discharge.
Compared with the prior art, the beneficial effects of the utility model are as follows:
1. the utility model discloses a totally enclosed is reinforced to be connected with nitrogen gas input pipeline on the solvent metering tank, reduced the air to the influence of material and the production of dust. The whole process adopts full-automatic feeding and conveying, so that the pollution of microorganisms is avoided, and the equipment is convenient to clean.
2. The utility model discloses a blast air stoving formula centrifuge, the material is heated evenly, and the product water content is low, the granule homogeneous. Personnel easy operation reduces the waste that the material transfer process caused, reduction equipment cost.
3. The utility model discloses filtrating (being centrifuge flowing back) can carry out recycle, increases material utilization, reduces the loss.
4. The utility model discloses a stoving formula centrifuge bottom adopts open-close type structure, reduces the drying process material loss, makes things convenient for the collection of material, is fit for industrial production.
Drawings
Fig. 1 is a schematic structural diagram of the present invention;
in the figure: 1. a nitrogen input line; 2. a solvent metering tank; 3. a solids metering tank; 4. a shower head; 5. a dissolution crystallization kettle; 6. an air intake line; 7. a preheater; 8. a centrifuge housing; 9. an inner shell of a centrifuge; 10. a filter cloth bag; 11. an air outlet pipeline; 12. a sealing cover; 13. a liquid discharge port; 14. and (4) a discharge port.
Detailed Description
The present invention will be further described with reference to the following detailed description.
Example 1
As shown in fig. 1, the refining device for gamma cyclodextrin comprises a solvent metering tank 2, a solid metering tank 3 and a drying centrifuge, wherein an outlet pipeline of the solvent metering tank 2 is divided into two branches, one branch is connected with an inlet of a dissolution crystallization kettle 5, and the other branch is connected with an inlet of the solid metering tank 3;
drying type centrifuge include centrifuge shell 8, centrifuge inner shell 9 and filter sack 10, 9 bottom end non-shutoff of centrifuge inner shell, filter sack 10 both sides and the laminating of centrifuge inner shell 9 both sides, filter sack 10 lower extreme and establish the opening, it establishes sealed lid 12 to correspond the opening, centrifuge shell 8 lower extreme is the toper, the toper is equipped with discharge gate 14 bottom, leakage fluid dram 13 is established to toper one side, air inlet line 6 is connected to the inner chamber upper end between centrifuge shell 8 and the centrifuge inner shell 9, establish pre-heater 7 on the air inlet line 6, air outlet line 11 is connected to the inner chamber lower extreme between centrifuge shell 8 and the centrifuge inner shell 9.
The solvent metering tank 2 is connected with a nitrogen input pipeline 1, and the influence of air on materials is reduced under the protection of nitrogen.
The inside shower head 4 that is equipped with of solid metering tank 3, the outlet pipeline of solvent metering tank 2 links to each other with the entrance point of shower head 4 for wash the material of adhesion on the 3 inner walls of solid metering tank.
Round holes are uniformly distributed on the side wall of the centrifuge inner shell 9 and are used for hot air to enter and exit in the centrifugal dehydration and drying processes.
And the liquid outlet 13 is connected with an inlet of the dissolution crystallization kettle 5 through a pipeline, so that the discharged liquid is recycled, the material utilization rate is increased, and the loss is reduced.
The sealing cover 12 is formed by splicing two semicircular plates and is convenient to open and close.
During operation, add solid metering tank 3 and solvent metering tank 2 with gamma cyclodextrin crude and solvent respectively, open 3 valves of solid metering tank and add the material in dissolving crystallization kettle 5, open solvent metering tank 2 to 3 valves of solid metering tank and with dissolve the continuous valve of crystallization kettle 5, wait that all materials are added and wash clean after, close the feed valve. After dissolving and crystallizing, the mixture is pumped into a drying centrifuge through a kettle bottom pipeline. The centrifuged filtrate was discharged through a liquid outlet 13 at one side and recovered in the crystallization vessel 5. Hot air is fed through the air inlet pipeline 6, the centrifuged material is dried by the hot air in the filter cloth bag 10, and finally the product with high purity, low moisture and uniform particle size is obtained. And opening the discharge port 14 and the sealing cover 12 at the bottom of the filtering cloth bag 10 to discharge.
It is understood that the above description is only a preferred embodiment of the present invention, and is not intended to limit the present invention in any way, and that any person skilled in the art may make modifications or changes to the equivalent embodiment using the above disclosure. However, any simple modification, equivalent change and modification made to the above embodiments according to the technical substance of the present invention still belong to the protection scope of the technical solution of the present invention.
Claims (6)
1. A refining plant of gamma cyclodextrin which characterized in that: the device comprises a solvent metering tank (2), a solid metering tank (3) and a drying centrifuge, wherein an outlet pipeline of the solvent metering tank (2) is divided into two branches, one branch is connected with an inlet of a dissolution crystallization kettle (5), and the other branch is connected with an inlet of the solid metering tank (3);
drying type centrifuge include centrifuge shell (8), centrifuge inner shell (9) and filter sack (10), centrifuge inner shell (9) bottom is not the shutoff, filter sack (10) both sides and the laminating of centrifuge inner shell (9) both sides, the opening is established to filter sack (10) lower extreme, sealed lid (12) are established to corresponding the opening, centrifuge shell (8) lower extreme is the toper, the toper is equipped with discharge gate (14) bottom, leakage fluid dram (13) are established to toper one side, air inlet line (6) is connected to inner chamber upper end between centrifuge shell (8) and centrifuge inner shell (9), establish pre-heater (7) on air inlet line (6), air outlet line (11) is connected to the inner chamber lower extreme between centrifuge shell (8) and centrifuge inner shell (9).
2. The apparatus for refining gamma cyclodextrin as claimed in claim 1, wherein: the solvent metering tank (2) is connected with a nitrogen input pipeline (1).
3. The apparatus for refining gamma cyclodextrin as claimed in claim 1, wherein: the inside of the solid metering tank (3) is provided with a spray header (4), and an outlet pipeline of the solvent metering tank (2) is connected with the inlet end of the spray header (4).
4. The apparatus for refining gamma cyclodextrin as claimed in claim 1, wherein: round holes are uniformly distributed on the side wall of the centrifuge inner shell (9).
5. The apparatus for refining gamma cyclodextrin as claimed in claim 1, wherein: the liquid outlet (13) is connected with the inlet of the dissolution crystallization kettle (5) through a pipeline.
6. The apparatus for refining gamma cyclodextrin as claimed in claim 1, wherein: the sealing cover (12) is formed by splicing two semicircular plates.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202120758212.1U CN215026147U (en) | 2021-04-14 | 2021-04-14 | Refining device of gamma cyclodextrin |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202120758212.1U CN215026147U (en) | 2021-04-14 | 2021-04-14 | Refining device of gamma cyclodextrin |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN215026147U true CN215026147U (en) | 2021-12-07 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202120758212.1U Active CN215026147U (en) | 2021-04-14 | 2021-04-14 | Refining device of gamma cyclodextrin |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN215026147U (en) |
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2021
- 2021-04-14 CN CN202120758212.1U patent/CN215026147U/en active Active
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