Cleaning disc for magnetic particle chemiluminescence analyzer
Technical Field
The utility model relates to the technical field of medical treatment external diagnosis check out test set, in particular to a washing dish for a magnetic particle chemiluminescence analyzer.
Background
Immunological detection is a means for detecting mainly by utilizing a specific reaction between an antigen and an antibody, and is often used for detecting a trace amount of a substance such as a protein or a hormone because a detection signal can be amplified and displayed by using an isotope, an enzyme, a chemiluminescent substance, or the like. From the sixties of the last century, immunoassays are widely used in scientific research and clinical fields. The development of radioimmunoassay from the very beginning to enzyme-linked immunoassays, to chemiluminescent immunoassays which are currently in widespread use, has progressed.
The chemiluminescence immunoassay analyzer is a novel labeling immunoassay technology which combines chemiluminescence or bioluminescence with immunoreaction and is used for detecting trace antigens or antibodies. Compared with the traditional radioimmunoassay, the chemiluminescence immunoassay technology is environment-friendly and safe, and has higher sensitivity and wider detection range compared with enzyme-linked immunity. The chemiluminescence immunodetection has the characteristics of environmental protection, rapidness, accuracy and the like, is generally accepted by people, and becomes a main means of clinical immunodiagnosis at present.
The chemiluminescence detection process comprises the steps of adding liquid into reactants, incubating the reactants, cleaning the unreacted reactants, filling the substrates, detecting light, collecting data signals and calculating. The cleaning of the unreacted reactant is a very critical loop in the chemiluminescence detection process, and is one of the most difficult points for realizing a chemiluminescence analyzer, and if the cleaning of the unreacted reactant cannot meet the requirement, the problems of inaccurate result, poor consistency and the like are directly caused. Unreacted substance cleaning modules in the current market are mainly cleaning disc type modules and matrix type modules, and have the problems that some structures are too complex, production and maintenance are difficult, functions are not perfect, partial instability exists, and the like.
Disclosure of Invention
The utility model provides a cleaning disc for a magnetic particle chemiluminescence analyzer, which overcomes the defects of the prior art.
The utility model discloses a realize through following technical scheme:
a cleaning disc for a magnetic particle chemiluminescence analyzer comprises a cleaning needle mechanism, a fixed disc body, a rotary disc, a driving assembly and a blending mechanism, wherein the cleaning mechanism is fixedly arranged on the fixed disc body through a cleaning mechanism lifting device; mixing mechanism is located washs the dish bottom, including the rotor support who installs a plurality of mixing rotors, and high-speed direct current motor is installed to rotor support's bottom, high-speed direct current motor passes through the hold-in range and is connected with the mixing rotor, install on the mixing rotor with the tight lantern ring of reaction cup complex.
The lateral wall of fixed disk body is installed the magnetic adsorption piece.
And a rotor lifting mechanism is arranged at the bottom of the rotor bracket.
The cleaning mechanism comprises a needle frame, and a substrate needle, a waste liquid sucking needle and a cleaning liquid needle are mounted on the needle frame.
The cleaning solution needle and the substrate needle are fixed on the needle frame.
The waste liquid sucking needle is installed on the needle frame through the needle sleeve and the spring and can be jacked up.
And a bearing matched with the reaction cup is arranged on the hole position of the reaction cup of the cleaning disc turntable.
The fixed tray body is also provided with a heating sheet.
The driving assembly is also provided with a sensor which is connected with the code disc.
The utility model discloses following technological effect has:
the utility model relates to a magnetic particle chemiluminescence analysis appearance is with wasing dish, the structure is simple and easy, multiple functional, the module is independent, can be applied to high, medium and low-speed chemiluminescence analysis appearance.
Drawings
The present invention will be further described with reference to the accompanying drawings.
FIG. 1 is a structural view of a cleaning disc.
Fig. 2 is an exploded view of the cleaning mechanism.
Figure 3 is an exploded view of the stationary plate.
FIG. 4 is an exploded view of the blending mechanism.
In the figure, 1.1-cleaning mechanism, 1.1.1-substrate needle, 1.1.2-waste liquid sucking needle, 1.1.3-cleaning liquid needle, 1.1.4-needle holder, 1.2-fixed disk body, 1.2.1-cleaning disk cover, 1.2.2-reaction cup, 1.2.3-fixed disk main body, 1.2.4-heating plate, 1.2.5-heating plate pressing plate, 1.2.6-cleaning mechanism lifting device, 1.3-rotating disk and driving component, 1.3.1-cleaning disk rotating disk, 1.3.2 reaction cup rotating bearing, 1.3.3-rotating disk driving motor, 1.3.4-coded disk, 1.3.5-sensor, 1.4 mixing mechanism, 1.4.1-mixing rotor, 1.4.1.1-lantern ring, 1.4.2-rotor lifting mechanism and 1.4.3-high-speed direct current motor.
Detailed Description
The following are only embodiments of the present invention, but the scope of the present invention is not limited thereto, and any changes or substitutions that can be easily conceived by those skilled in the art within the technical scope of the present invention should be covered by the present invention.
In the present invention, the words describing the directional relationship such as "front", "back", "inner", "outer" are only used for convenience of description of the embodiment, and are not considered as limitations of the present invention. The terms "first," "second," and the like are used solely to distinguish one from another and are not to be construed as indicating or implying relative importance. The fixed connection or installation mode includes but is not limited to welding, spiro union, joint, interference fit, integrated into one piece. The side-by-side relationship not only refers to a linear arrangement relationship, but also includes a positional relationship in which the modules are substantially in a straight line but have a certain deviation.
Fig. 1 and fig. 3 show an embodiment of the present invention. The embodiment provides a cleaning disc for a magnetic particle chemiluminescence analyzer, which comprises a cleaning needle mechanism 1.1, a fixed disc body 1.2, a rotary disc and driving assembly 1.3, a uniform mixing mechanism 1.4 and a liquid path system.
The cleaning mechanism 1.1 is arranged on the cleaning mechanism lifting device 1.2.6, and the cleaning mechanism lifting device 1.2.6 is fixedly arranged on the fixed disk main body 1.2.3 of the fixed disk body 1.2. The cleaning mechanism 1.1 comprises a needle frame 1.1.4, and a plurality of substrate needles 1.1.1, waste liquid sucking needles 1.1.2 and cleaning liquid needles 1.1.3 are arranged on the needle frame 1.1.4. Wherein the cleaning solution needle 1.1.3 and the substrate needle 1.1.1 are fixed on the needle frame 1.1.4 and can not move; inhale waste liquid needle 1.1.2 and installed on needle frame 1.1.4 through needle external member and spring, can be jack-up, realized that many inhale waste liquid needles 1.1.2 and installed on a needle frame 1.1.4, guarantee through needle jack-up that all inhale waste liquid needles 1.1.2 all insert reaction cup 1.2.2 bottom, completely absorb the waste liquid in the reaction cup 1.2.2 totally.
The cleaning mechanism lifting device 1.2.6 is a synchronous belt vertical lifter consisting of a linear motor, a guide rail, a synchronous wheel synchronous belt and a needle frame fixing piece, and the needle frame 1.1.4 is driven by the linear motor to move up and down; a substrate needle 1.1.1, a waste liquid sucking needle 1.1.2 and a cleaning liquid needle 1.1.3, wherein a needle frame 1.1.4 is controlled to be arranged at the same height through a cleaning mechanism lifting device 1.2.6, and liquid is added or absorbed by judging whether a reaction cup 1.2.2 is arranged below the needle body and driving an injection pump or a waste liquid sucking peristaltic pump or a substrate pump of a liquid path system; the cleaning mechanism 1.1 can be changed into cleaning processes of different orders, and cleaning liquid adding or cleaning liquid adding and waste liquid sucking combination can be independently carried out at each order; the cleaning mechanism 1.1 and the liquid path system are the most key parts for filling cleaning liquid and removing waste liquid in the cleaning process, and the purposes of removing unreacted substances and testing expected objects to be tested are achieved by sucking the waste liquid and filling the cleaning liquid.
Fixed disk body 1.2 includes fixed disk main part 1.2.3, with fixed disk main part 1.2 the disk lid of looks adaptation, install the magnetic adsorption piece on fixed disk main part 1.2.3's lateral wall, install magnet in the magnetic adsorption piece, magnetic adsorption piece magnet installation position has not co-altitude, according to different reaction cup 1.2.2 height or different magnetic particle magnet, use the magnetic adsorption piece of co-altitude and quantity, when reaching complete magnetic adsorption, also guarantee easily to break away, easily heavy suspension.
The rotary disc and driving assembly 1.3 comprises a cleaning disc rotary disc 1.3.1 and a driving assembly, the fixed disc main body 1.2.3 is fixedly arranged at the top of the driving assembly, the cleaning disc rotary disc 1.3.1 is positioned inside the fixed disc main body 1.2.3 and is arranged on a rotating shaft of the driving assembly and is a bearing platform of the reaction cup 1.2.2, in order to reduce the friction between the reaction cup 1.2.2 and the rotary disc in the uniform mixing process, a reaction cup rotating bearing 1.3.2 matched with the reaction cup 1.2.2 is fixed on the cleaning disc rotary disc 1.3.1, and the driving assembly is positioned at the bottom of the fixed disc main body 1.2.3. The bottom of the fixed disk main body 1.2.3 is provided with a heating plate 1.2.4 through a heating plate pressing plate 1.2.5.
A synchronizing wheel and a code wheel 1.3.4 are arranged on a rotating shaft of the driving component, the synchronizing wheel is connected with a rotary disc driving motor 1.3.3 through a synchronous belt, and a sensor 1.3.5 connected with the code wheel 1.3.4 is also arranged on the driving component.
Mixing mechanism 1.4 is located washs the dish bottom, it is cyclic annular wholly, drive assembly is located in the middle of mixing mechanism 1.4, specifically including installing the annular rotor support of a plurality of mixing rotors 1.4.1, rotor support's bottom is installed on rotor elevating system 1.4.2 and is installed high-speed direct current motor 1.4.3, high-speed direct current motor 1.4.3 is connected with mixing rotor 1.4.1 through the hold-in range, high-speed direct current motor 1.4.3's output promptly, mixing rotor 1.4.1 all installs the synchronizing wheel, the two passes through the hold-in range and connects. Connecting the high-speed direct current motor 1.4.3 with a plurality of belt pulleys by using a synchronous belt pulley to form simultaneous rotation of the plurality of synchronous belt pulleys, installing a tight sleeve ring 1.4.1.1 on the blending rotor 1.4.1, tightly sleeving the reaction cup 1.2.2 by the blending rotor 1.4.1, and driving the blending rotor 1.4.1 to rotate by the high-speed direct current motor 1.4.3 so as to realize uniform mixing and heavy suspension of the reaction liquid in the reaction cup 1.2.2; the holes of the reaction cup holes of the cleaning disc rotating disc 1.3.1 are provided with bearings 1.3.2 matched with the reaction cups 1.2.2, when the mixing rotor 1.4.1 is sleeved on the reaction cups 1.2.2 to rotate, the bearings 1.3.2 on the cleaning disc rotating disc 1.3.1 are driven to rotate by friction, and the rotating disc 1.3.1 and the reaction cups 1.2.2 do not directly rub.
The rotor lifting mechanism 1.4.2 is a linear motor and realizes the up-and-down movement of the whole blending mechanism; the mixing mechanism realizes the heavy suspension of the magnetic particles in the cleaning process, releases unreacted substances wrapped in the magnetic particles and ensures that the cleaning is more complete.
The liquid path system comprises a cleaning liquid adding injection pump and valve, a waste liquid sucking pump and valve and a substrate liquid injection pump and valve; each cleaning liquid needle 1.1.3 is connected with an independent cleaning liquid adding injection pump valve, and each step of cleaning is independently filled with different cleaning liquid amounts; the substrate needle 1.1.1 is connected with a substrate injection pump and a valve separately, and the substrate is filled separately. The waste liquid suction needle 1.1.2 is separately connected with a waste liquid suction pump and a valve.