CN214963222U - De-derivatization drug delivery device - Google Patents
De-derivatization drug delivery device Download PDFInfo
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- CN214963222U CN214963222U CN202023307455.8U CN202023307455U CN214963222U CN 214963222 U CN214963222 U CN 214963222U CN 202023307455 U CN202023307455 U CN 202023307455U CN 214963222 U CN214963222 U CN 214963222U
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Abstract
The utility model discloses a remove and derive and administer device and contain device's skin care products, including stock solution storehouse, driving pump and remove and derive separator. The derivatisation solution comprising the skin care active derivative is stored stably in a reservoir. When in use, the driving pump drives the derivatization solution to pass through the derivatization removing channel, and derivatization is removed under the action of the enzymatic filler, so that the active substance with good efficacy is obtained. The device solves the dual requirements of stable storage and better effect, has simple structure and low cost, and has wider application prospect in the field of skin care products and drug delivery.
Description
Technical Field
The utility model relates to the technical field of cosmetics, in particular to a de-derivatization drug delivery device.
Background
In the cosmetic field, the preparation of unstable active substances as stably present derivatives is an important means of solving the instability of ingredients. However, the efficacy of the active substance is reduced or even lost when it is prepared as a derivative. Therefore, a proper derivative group is selected, so that the active substance has good stability and can keep better efficacy. This is difficult to achieve in the course of practical development and is a major key problem limiting the use of unstable actives in cosmetics.
SUMMERY OF THE UTILITY MODEL
The utility model aims at providing a remove to derive and administer the device to the technical defect that skin care active derivative efficiency reduces among the prior art, remove among the device and derive separator, through closely filling the enzyme-based filler that removes in the channel of deriving to the derivation solution that the channel of deriving is removed to the flow through carrying out the enzyme digestion, thereby get rid of the derivation group when using and obtain better efficiency on the basis of stable storage.
For realizing the utility model discloses a technical scheme that the purpose adopted is:
a de-derivatization drug delivery device comprises a liquid storage bin for storing a derivatization solution, a driving pump communicated with the liquid storage bin to drive the derivatization solution to flow out, and a de-derivatization separation device, wherein one end of the de-derivatization separation device is communicated with the liquid storage bin, and the other end of the de-derivatization separation device is provided with a liquid outlet;
the de-derivatization separation device comprises a de-derivatization channel and an enzymatic filler tightly filled in the de-derivatization channel;
the derivatization solution enters the de-derivatization channel under the driving of the driving pump, is de-derivatized under the action of the enzymatic filler, and then flows out of the liquid outlet.
In the technical scheme, the liquid storage bin, the derivatization removing channel and the liquid outlet are of an integrated connecting structure, the two ends of the derivatization removing channel are respectively provided with the filter cores, and the enzymatic filler is tightly filled between the two filter cores.
In the technical scheme, the liquid storage bin is provided with a first connecting pipe, one end of the derivative removing device is provided with a second connecting pipe, and the first connecting pipe and the second connecting pipe are connected through threads, interference connection or buckles.
In the technical scheme, the liquid storage bin is provided with a liquid supplementing port for supplementing the derivative solution, and a sealing cover is arranged outside the liquid supplementing port.
In the above technical scheme, an air pump is connected to the second connecting pipe to blow out the residual solution in the derivatization removing channel; the first connecting pipe is provided with a one-way valve to prevent the derivative solution from flowing back.
In the above technical scheme, the inflation pump is a balloon or an air pump.
In the above technical scheme, a dust cover is arranged outside the liquid outlet, and the dust cover is in one of a cylinder, a cube, a prism and a circular truncated cone.
In the above technical solution, the enzymatic filler is a resin filler adsorbed with a de-derivatizing enzyme, and the de-derivatizing enzyme includes one of glucosidase, phosphatase, palmitatase, pectate esterase and propionate esterase; the resin filler is macroporous resin.
In the above technical scheme, the mass ratio of the de-derivatizing enzyme to the resin filler is 1: (5-10000).
In the technical scheme, the one-time dosage of the driving pump is 0.1-5mL, and the flow rate of the de-derivatization separation device is 0.01-1 mL/s.
In another aspect of the present invention, the use of a de-derivatisation delivery device for delivery of skin care products and drugs.
In another aspect of the present invention, a skin care product comprises the above-mentioned de-derivative drug delivery device and a derivative solution stored in a reservoir.
In the technical scheme, the derivative solution comprises a skin care active derivative, a skin care base component and water; the mass ratio of the skin care active derivative to the skin care basic component to the water is (5-10): (10-20): 100.
in the technical scheme, the skin care active derivative comprises one or a mixture of a vitamin C derivative, a vitamin E derivative and a retinol derivative in any proportion; the vitamin C derivative comprises one of ascorbyl glucoside, ascorbyl phosphate, ascorbyl palmitate and ascorbyl methylsilanol pectate; the vitamin E derivative comprises one of vitamin E succinate, vitamin E linoleate and vitamin E glucoside; the retinol derivative includes one of retinol palmitate and retinol propionate.
In the technical scheme, the skin care basic component comprises one or a mixture of any proportion of hyaluronic acid and salts thereof, polyols, hydroxyethyl urea, natural oil, synthetic oil, olefin, alkane, sugar, glycan, sugar alcohol, collagen and moisturizing plant extracts;
the polyalcohol comprises one or a mixture of butanediol, propylene glycol, pentanediol, octaethylene glycol, dipropylene glycol and glycerol in any proportion;
the natural oil comprises one or a mixture of any proportion of olive oil, squalane, jojoba seed oil, sunflower seed oil, macadamia nut oil, orange fruit fat, gamboge fat, cocoa butter and shea butter;
the synthetic grease comprises one or a mixture of hydrogenated polydecene, glyceride, caprylic capric triglyceride, isononyl isononanoate, cetyl alcohol ester, myristyl alcohol ester, pentaerythritol ester, coconut oil alcohol ester, alkanol ester and palmitic acid alcohol ester in any proportion.
In the technical scheme, the composition also comprises 20-50 parts of compound components; the compound components comprise one or the mixture of ferulic acid, scutellaria baicalensis extract, polyglutamic acid, shea butter, an anti-aging and anti-wrinkle compound and plant extract in any proportion;
the anti-aging and anti-wrinkle compound comprises one or more of fullerene, dimethylaminoethanol tartrate, salicylic acid and aminobutyric acid in any proportion;
the plant extract comprises one or more of flos Rosae Davuricae extract, semen Arachidis Hypogaeae extract, fructus Vitis Viniferae extract, rhizoma Polygoni Cuspidati extract, TAKUIYANGYE extract, fructus Zanthoxyli extract, herba Centellae extract, Ginseng radix extract, Cordyceps extract, herba Cibotii extract, Glycyrrhrizae radix extract and fructus Mori extract.
In another aspect of the present invention, in the method for using the skin care product, the derivative solution is derived by the derivative-removing administration device and then applied to the part to be cared.
Compared with the prior art, the beneficial effects of the utility model are that:
1. the utility model provides a remove and derive and administer the device, will contain the stable storage in stock solution storehouse of the derived solution of skin care active derivative. When in use, the driving pump drives the derivatization solution to pass through the derivatization removing channel, and derivatization is removed under the action of the enzymatic filler, so that the active substance with good efficacy is obtained. The device solves the dual requirements of stable storage and better effect, has simple structure and low cost, and has wider application prospect in the field of skin care products and drug delivery.
2. The utility model provides a skin care product, wherein the derivative solution stored comprises skin care active derivative, skin care basic component and water. Unstable skin care actives are formulated as skin care active derivatives to improve their stability. When in use, the skin care active substance protomer is obtained by derivatization of corresponding dedifferentiation enzyme, thereby enlarging the selectable range of the derivatization group of the skin care active substance protomer and simultaneously improving the efficacy of the skin care active substance.
3. The utility model provides a skin care product, because skin care active derivative's stability is higher, consequently need not to add extra stable ingredient in deriving the solution.
Drawings
FIG. 1 is a schematic view of the structure of the de-derivatized drug delivery device of example 1;
fig. 2 is a schematic structural view of the de-derivatization drug delivery device of example 2.
In the figure: 1-driving pump, 2-liquid storage bin, 3-filter element, 4-derivatization removing channel, 5-enzymatic filler, 6-liquid outlet, 7-dustproof cover, 8-first connecting pipe, 9-second connecting pipe, 10-liquid supplementing port, 11-sealing cover, 12-inflating pump and 13-one-way valve.
Detailed Description
The present invention will be described in further detail with reference to specific examples. It should be understood that the specific embodiments described herein are merely illustrative of the invention and are not intended to limit the invention.
Example 1
A de-derivatization drug delivery device comprises a liquid storage bin 2 for storing a derivatization solution, a driving pump 1 communicated with the liquid storage bin 2 to drive the derivatization solution to flow out, and a de-derivatization separation device, wherein one end of the de-derivatization separation device is communicated with the liquid storage bin 2, and the other end of the de-derivatization separation device is provided with a liquid outlet 6; the de-derivatization separation device comprises a de-derivatization channel 4 and an enzymatic filler 5 tightly filled in the de-derivatization channel 4; the derivatization solution enters the de-derivatization channel 4 under the driving of the driving pump 1, is de-derivatized under the action of the enzymatic filler 5, and then flows out of the liquid outlet 6.
As shown in fig. 1, the liquid storage bin 2, the derivatization removing channel 4 and the liquid outlet 6 are an integral connecting structure, two ends of the derivatization removing channel 4 are respectively provided with a filter element 3, and the enzymatic filler 5 is tightly filled between the two filter elements 3.
The de-derivatization drug delivery device in the embodiment has the advantages of simple structure and lower manufacturing cost, and is suitable for daily use.
The enzymatic filler 5 is a resin filler adsorbed with a de-derivatization enzyme, and the de-derivatization enzyme is glucosidase; the resin filler is D-101 type macroporous adsorption resin.
In the embodiment, the de-derivatization enzyme is changed into glucosidase which is one of phosphatase, palmitate esterase, pectate esterase and propionate esterase, or the D-101 type macroporous adsorption resin is changed into macroporous resin HPD750, macroporous resin HPD-600 and macroporous resin AB-8, so that the integral structure and the use of the de-derivatization drug delivery device are not influenced. The choice of enzymatic filler is determined by the type of derivative in the derivatisation solution.
The mass ratio of the de-derivatization enzyme to the resin filler is 1: 1000. the one-time administration amount of the drive pump 1 was 0.5mL, and the flow rate of the dedifferentiation separation apparatus was 0.1 mL/s.
The mass ratio of the dedifferentiation enzyme to the resin filler in this example was changed to 1: (5-10000) without affecting the whole structure and use of the de-derivative drug delivery device. When the mass ratio of the dedifferentiating enzyme to the resin filler is increased, that is, the amount of the dedifferentiating enzyme is relatively increased, the one-time administration amount of the driving pump 1 and the flow rate of the dedifferentiation separation means can be increased accordingly.
Preferably, a dustproof cover 7 is arranged outside the liquid outlet 6, and the dustproof cover 7 is in the shape of a circular truncated cone, so that cleanness and sanitation can be kept, and the dustproof cover can be used as a base to keep the whole device stable.
The shape of the dust cover 7 is changed into one of a cube, a prism and a cylinder, and the overall structure and the use of the de-derivative drug delivery device are not influenced.
Example 2
This example is based on example 1 and describes another de-derivatization drug delivery device.
As shown in fig. 2, a first connecting pipe 8 is arranged on the liquid storage bin 2, a second connecting pipe 9 is arranged at one end of the derivatization removing device, and the first connecting pipe 8 is connected with the second connecting pipe 9 through threads.
The first connecting pipe 8 and the second connecting pipe 9 are connected in an interference fit manner or in a buckling manner through threads in the embodiment, so that the overall structure and the use are not affected, and the derivative removing device and the liquid storage bin can be connected in a replaceable manner.
The liquid storage bin 2 is provided with a liquid supplementing port 10 for supplementing the derived solution, a sealing cover 11 is arranged outside the liquid supplementing port 10, and the position of the liquid supplementing port 10 can be adjusted according to actual use convenience. When liquid supplement is needed, the sealing cover 11 is opened, liquid supplement is carried out from the liquid supplement port 10 through a pipeline or a funnel, and the sealing cover 11 is tightly covered after liquid supplement is finished.
The volume of the reservoir 2 and the size of the de-derivatisation apparatus can be made larger than in example 1. After the derived solution in the liquid storage bin 2 is used up, the sealing cover 11 is opened, the derived solution is supplemented through the liquid supplementing port 10, the derived device is replaced, the liquid storage bin 2 and the driving pump 1 can be repeatedly used, the cost is reduced, and the liquid storage bin is more suitable for places with larger usage amount of skin care products such as beauty parlors.
An inflation pump 12 is connected to the second connecting pipe 9 to blow out the residual solution in the derivatization removing channel, and the inflation pump 12 is a balloon; the first connecting pipe 8 is provided with a one-way valve 13 to prevent back flow of the derivatizing solution. The residual solution in the de-derivatization channel is blown out, so that the residual solution is prevented from deteriorating in the de-derivatization channel to pollute the enzymatic filler 5, and the residual solution is also prevented from being wasted.
In this embodiment, because the volume of stock solution storehouse 2 and the size of removing the derivatization device are great compared in embodiment 1, stock solution storehouse 2 can cooperate the support to be fixed.
Example 3
The No. 1 derivative solution comprises 10 parts of ascorbyl phosphate (magnesium salt), 4 parts of hyaluronic acid, 4 parts of hydroxyethyl urea, 10 parts of glycyrrhiza glabra extract, 10 parts of glycyrrhiza extract and 100 parts of water in parts by mass.
The No. 2 derivative solution comprises 2 parts of ascorbyl palmitate, 3 parts of retinol palmitate, 3 parts of hyaluronic acid, 5 parts of polyols, 3 parts of natural oil and fat, 4 parts of sugar alcohol, 20 parts of tremella extract, 3 parts of ferulic acid, 5 parts of polyglutamic acid and 100 parts of water in parts by mass.
The No. 3 deriving solution comprises 3 parts of ascorbyl glucoside, 3 parts of vitamin E glucoside, 5 parts of hydroxyethyl urea, 10 parts of polyalcohol, 5 parts of collagen, cherry extract, centella asiatica extract and 100 parts of water in parts by mass.
Example 4
Skin care product No. 1 comprising the de-derivatizing drug delivery device of example 1 and the derivatizing solution of example 3 stored in a reservoir. Wherein the de-derivatizing enzyme in the de-derivatizing administration device is phosphatase.
A skin care product No. 2 comprising the de-derivatizing drug delivery device of example 2 and a derivatizing solution No. 2 of example 3 stored in a reservoir. Wherein the de-derivatizing enzyme in the de-derivatizing administration device is a palmitoyl esterase.
A skin care product No. 3 comprising the de-derivatizing drug delivery device of example 1 and a derivatizing solution No. 3 of example 3 stored in a reservoir. Wherein the de-derivatizing enzyme in the de-derivatizing drug delivery device is a glucosidase.
The use method of the skin care product comprises the steps of starting the driving pump 1, driving the derivatization solution in the liquid storage bin 2 to enter the derivatization removing channel 4, performing derivatization under the action of the enzymatic filler 5, then flowing out from the liquid outlet 6, and coating the liquid on the part to be treated.
The foregoing is only a preferred embodiment of the present invention, and it should be noted that, for those skilled in the art, a plurality of improvements and decorations can be made without departing from the principle of the present invention, and these improvements and decorations should also be regarded as the protection scope of the present invention.
Claims (10)
1. The de-derivatization drug delivery device is characterized by comprising a liquid storage bin for storing a derivatization solution, a driving pump communicated with the liquid storage bin for driving the derivatization solution to flow out and a de-derivatization separation device, wherein one end of the de-derivatization separation device is communicated with the liquid storage bin, and the other end of the de-derivatization separation device is provided with a liquid outlet;
the de-derivatization separation device comprises a de-derivatization channel and an enzymatic filler tightly filled in the de-derivatization channel;
the derivatization solution enters the de-derivatization channel under the driving of the driving pump, is de-derivatized under the action of the enzymatic filler, and then flows out of the liquid outlet.
2. The de-derivatization drug delivery device according to claim 1, wherein the reservoir, the de-derivatization channel and the liquid outlet are an integral connecting structure, two ends of the de-derivatization channel are respectively provided with a filter element, and the enzymatic filler is tightly filled between the two filter elements.
3. The de-derivatization drug delivery device according to claim 1, wherein the reservoir is provided with a first connecting pipe, one end of the de-derivatization device is provided with a second connecting pipe, and the first connecting pipe and the second connecting pipe are connected through a threaded connection, an interference connection or a snap connection.
4. The de-derivatization drug delivery device according to claim 3, wherein the reservoir is provided with a fluid infusion port for supplementing the derivatized solution, and a sealing cover is mounted outside the fluid infusion port.
5. The de-derivatization drug delivery device of claim 3, wherein an air pump is connected to the second connecting pipe to blow out residual solution in the de-derivatization channel; the first connecting pipe is provided with a one-way valve to prevent the derivative solution from flowing back.
6. The de-derivatized drug delivery device of claim 5, wherein the inflation pump is a balloon or an air pump.
7. The de-derivatization drug delivery device of claim 1, wherein a dust cap is disposed outside the fluid outlet, the dust cap being one of cylindrical, cubic, prismatic, and frustoconical in shape.
8. The de-derivatized drug delivery device of claim 1, wherein the enzymatic filler is a resin filler having de-derivatized enzyme adsorbed thereto, the de-derivatized enzyme comprising one of glucosidase, phosphatase, palmitate, pectate, succinate, linoleate, and propionate; the resin filler is macroporous resin.
9. The de-derivatized drug delivery device according to claim 8, wherein the mass ratio of the de-derivatized enzyme to the resin filler is 1: (5-10000).
10. The de-derivatized drug delivery device of claim 9, wherein the pump is actuated to deliver a dose of 0.1 to 5mL at a time, and the de-derivatized separation device has a flow rate of 0.01 to 1 mL/s.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202023307455.8U CN214963222U (en) | 2020-12-31 | 2020-12-31 | De-derivatization drug delivery device |
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| Application Number | Priority Date | Filing Date | Title |
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| CN202023307455.8U CN214963222U (en) | 2020-12-31 | 2020-12-31 | De-derivatization drug delivery device |
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| CN214963222U true CN214963222U (en) | 2021-12-03 |
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| CN202023307455.8U Active CN214963222U (en) | 2020-12-31 | 2020-12-31 | De-derivatization drug delivery device |
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Effective date of registration: 20220907 Address after: Tianning District Hehai road 213000 Jiangsu city of Changzhou province No. 9 Patentee after: CHANGZHOU YOUDUN INDUSTRIAL INVESTMENT CO.,LTD. Address before: 250000 Huihe Industrial Park, Zhaili Town, Laiwu nonggao District, Jinan City, Shandong Province Patentee before: Shandong Tantuo Agricultural Technology Co.,Ltd. |
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