CN214930944U - High-quality and low-residual-oxygen powder injection preparation subpackaging and nitrogen charging device - Google Patents

Abstract

The utility model provides a nitrogen device is filled in partial shipment of high quality, low residual oxygen's powder injection preparation, it includes nitrogen gas storage unit, control valve, filter, conveying unit and seals the nitrogen part. Set up first nitrogen sealing part before lower powder device respectively, set up second nitrogen sealing part before the tamponade device, make powder needle preparation partial shipment get into the medicinal bottle that is filled with nitrogen gas, the long and narrow gas outlet that the second nitrogen sealing part set up can guarantee to fill nitrogen gas device in certain extent before the tamponade and enough nitrogen gas sent into in the bottle when medicinal bottle is carried or is stopped. Simultaneously, the baffle of cooperation setting in medicinal bottle both sides avoids the outside air current of partial shipment process to filling nitrogen environmental disturbance, can fill nitrogen to medicinal bottle continuous stable efficient, effectively reduces the residual oxygen volume, practices thrift nitrogen gas, also improves medicine stability effectively, prolongs medicine save time, reduction in production cost.

Description

High-quality and low-residual-oxygen powder injection preparation subpackaging and nitrogen charging device

Technical Field

The utility model relates to a nitrogen filling device in the medicine packaging process in the pharmacy field, in particular to powder injection preparation partial shipment nitrogen filling device suitable for medicine partial shipment machine.

Background

In the production of preparations, some medicines have special physical and chemical properties, and in order to prevent or delay the deterioration of easily oxidized medicines and prolong the shelf life of the medicines, the medicines must be protected by nitrogen. Therefore, it is necessary to fill nitrogen into the container during the process of packaging the medicine to exhaust other mixed gases in the container, so as to alleviate the change of the color grade of the medicine by the inertia of nitrogen, thereby achieving the effect of improving the stability of the medicine.

The design of the existing airflow racking machine or screw racking machine is that nitrogen is filled before a rubber plug is covered after a powder injection preparation is dumped into a medicinal bottle, although the oxygen content in the medicinal bottle can be effectively reduced, a loose powder injection preparation has a certain residual oxygen content, and the actual detection shows that the medicine can generate large color grade change along with the approaching of the validity period, so that the internal quality and the medicine property of the medicine are influenced.

In addition, in the actual production, when a large-size powder injection preparation is subpackaged, for example, powder injection preparations with the sizes of 1.5g and more than 1.5g are subpackaged in a medicinal bottle, the loose powder injection preparation occupies a larger volume in the medicinal bottle, and the existing nitrogen filling technology cannot effectively fill nitrogen, so that the residual oxygen content is too high.

Therefore, an optimized nitrogen filling device is needed to be designed, so that the residual oxygen amount in the powder injection preparation is further reduced, the content of mixed gas in the medicinal bottle is reduced, and the waste of nitrogen is reduced.

SUMMERY OF THE UTILITY MODEL

In order to solve the problem, the utility model provides an optimize modified high quality, the nitrogen device is filled to powder injection preparation partial shipment of low residual oxygen, through the nitrogen position that fills of design powder injection preparation partial shipment in-process, realize before powder injection preparation partial shipment, fill nitrogen in advance in to the medicinal bottle, after powder injection preparation partial shipment, recycle and seal the air in the medicinal bottle of nitrogen part replacement with high-purity nitrogen gas, seal the inner structure of nitrogen part through the design, promote and fill nitrogen effect, especially, the nitrogen effect that fills of powder injection preparation partial shipment of specification more than 1.5g and 1.5g has been promoted, effectively reduce residual oxygen volume, reduce the waste of nitrogen gas.

An object of the utility model is to provide a nitrogen device is filled in partial shipment of powder needle preparation, store unit, control valve, filter, conveying unit and seal the nitrogen part including nitrogen gas. When filling nitrogen, the control valve is opened, the nitrogen gas reaches the nitrogen sealing part from the nitrogen gas storage unit through the filter and the conveying unit, and then the nitrogen sealing part is filled into the medicine bottle.

The nitrogen storage unit stores nitrogen with the purity not lower than 99.999 percent, and the nitrogen storage unit is a nitrogen source of the powder injection split charging nitrogen filling device.

The control valve is connected with the conveying unit through a filter and used for controlling the flow of nitrogen in the conveying pipeline, the flow rate of the air flow and/or the pressure of the air flow; the control valve is preferably a precision control valve, and comprises a pressure reducing valve, a ball valve for closing, a control battery valve and a safety valve.

The filter is a precise sterile filter, and after nitrogen is filtered, the nitrogen can meet the medicinal requirement of the powder injection, for example, the pore diameter of the filter is less than or equal to 0.22 micron.

The conveying unit controls the transmission path of the nitrogen, can play roles in buffering pressure, distributing and shunting, and conveys the nitrogen passing through the filter to the air inlet of the nitrogen sealing component at the designated position.

The nitrogen sealing component is arranged above the medicinal bottle and used for filling nitrogen into the medicinal bottle. The nitrogen sealing part comprises a first nitrogen sealing part and a second nitrogen sealing part, and the internal and external structures of the first nitrogen sealing part and the second nitrogen sealing part are preferably the same.

The utility model discloses in, on the direction of transmission of medicinal bottle, first nitrogen part setting is before lower powder device, and the second nitrogen part setting is before the tamponade device.

The first nitrogen sealing part is a linear part, is arranged along the track direction of the conveying unit, and is provided with a top wall, a bottom wall and a side wall, and a hollow cavity is formed in the first nitrogen sealing part in a hollow mode. The side wall is provided with a plurality of air inlets which are in a point distribution type.

The first nitrogen sealing component is provided with an air outlet, the air outlet penetrates through the lower inclined plane at the front end of the first nitrogen sealing component and the tail end of the first nitrogen sealing component, and the air outlet is in a slit shape.

The utility model provides a powder needle preparation partial shipment secondary nitrogen charging device powder needle preparation has following beneficial effect:

(1) the first nitrogen sealing part in the powder injection preparation of the powder injection preparation subpackaging and nitrogen filling device is arranged before the powder feeding device, nitrogen is prefilled for one time to an empty medicine bottle before subpackaging, then subpackaging is carried out, the residual oxygen quantity in the large-specification powder injection preparation medicine bottle can be effectively reduced, the residual oxygen quantity of the powder injection preparation with the specification of more than 1.5g and more than 1.5g is reduced to be less than 1% from 1% -3%, the problem that the powder injection preparation with the specification of more than 1.5g and more than 1.5g is loose is effectively solved, the occupied volume in the medicine bottle is large, the technical problem that the nitrogen cannot be effectively filled due to the fact that the powder occupies the space in the medicine bottle in an extruding mode in the existing nitrogen filling scheme is solved, and the subpackaging of the powder injection preparation with high quality and low residual oxygen is realized.

(2) Through design the utility model provides a seal nitrogen part structure seals nitrogen part front end at first nitrogen part and second and forms solitary compartment, can increase the exit pressure of nitrogen gas, reaches better nitrogen filling effect.

(3) The utility model provides a second seals nitrogen part can fill nitrogen to the medicinal bottle that is equipped with powder injection before the tamponade, and extension second seals nitrogen part increases nitrogen filling process time before the tamponade, improves the effect of filling nitrogen replacement.

(4) Through the utility model provides a seal appearance structure of nitrogen part, the use of cooperation baffle, along medicinal bottle transmission direction, form nitrogen atmosphere in medicinal bottle outside, prevent that outside air current from getting into medicinal bottle, influence fills the nitrogen effect, has guaranteed the nitrogen environment fully.

Drawings

Fig. 1 shows a schematic arrangement distribution diagram of a first nitrogen sealing part, a powder discharging device, a second nitrogen sealing part and a plugging device in the utility model;

fig. 2 shows a schematic structural view of a first nitrogen sealing member or a second nitrogen sealing member of the present invention;

FIG. 3 is a schematic view showing the positional relationship between a first nitrogen sealing member or a second nitrogen sealing member and a medicine bottle according to the present invention;

fig. 4 is a schematic structural view showing an included angle between an upper inclined surface and a lower inclined surface at the front end of the first nitrogen sealing part or the second nitrogen sealing part of the present invention;

fig. 5 shows a schematic structural diagram of a first-stage compartment and a second-stage compartment inside a nitrogen sealing component in the present invention.

Description of the reference numerals

1-nitrogen sealing component;

101-a first nitrogen sealing part;

1011-top wall;

1012-bottom wall;

1013-side walls;

1014-a hollow cavity;

141-first stage compartment;

142-a second-stage compartment;

1015-gas outlet;

1016-air inlet;

1017-upper inclined plane;

1018-lower slope;

102-a second nitrogen sealing part;

2-baffle plate.

Detailed Description

The present invention will be described in detail with reference to the following embodiments, and the features and advantages of the present invention will become more apparent and clear with the description.

The word "exemplary" is used exclusively herein to mean "serving as an example, embodiment, or illustration. Any embodiment described herein as "exemplary" is not necessarily to be construed as preferred or advantageous over other embodiments. While the various aspects of the embodiments are presented in drawings, the drawings are not necessarily drawn to scale unless specifically indicated.

In the nitrogen charging link of powder injection preparation subpackaging, different nitrogen charging devices are often selected based on different tamponade devices. In the prior art, the cork pressing device is generally a wheel-shaped cork or a linear cork, and correspondingly, a nitrogen charging device with linearly arranged air outlets or a nitrogen charging device with wheel-shaped arranged air outlets are selected, wherein the air outlets are distributed in a dotted intermittent manner, such as nitrogen charging devices in chinese patents CN210793769U and CN 104260923A. On one hand, when the medicine sub-packaging medicine bottle moves, the medicine bottle can not be continuously filled with nitrogen through the air outlet, so that the residual oxygen amount in the medicine bottle after being capped and plugged is higher. On the other hand, a larger nitrogen pressure is required to be provided for flushing the mixed gas in the medicinal bottle, the consumption of the nitrogen is large, and the utilization rate is low. On the other hand, the nitrogen filling process is carried out after the powder injection preparation is subpackaged, and part of mixed gas such as air and the like is brought into the powder injection preparation, so that the residual oxygen content is high.

The utility model provides a nitrogen filling device for split charging of powder injection preparations, which comprises a nitrogen storage unit, a control valve, a filter, a conveying unit and a nitrogen sealing part 1. When filling nitrogen, the control valve is opened, the nitrogen gas reaches the nitrogen sealing part 1 from the nitrogen gas storage unit through the filter and the conveying unit, and then the nitrogen sealing part 1 fills the medicine bottle.

The nitrogen storage unit stores nitrogen with the purity not lower than 99.999 percent, and the nitrogen storage unit is a nitrogen source of the powder injection split charging nitrogen filling device.

The control valve is connected with the conveying unit through a filter and used for controlling the flow of nitrogen in the conveying pipeline, the flow rate of the air flow and/or the pressure of the air flow; the control valve is preferably a precision control valve, and comprises a pressure reducing valve, a ball valve for closing, a control battery valve and a safety valve.

The filter is a precise sterile filter, and after nitrogen is filtered, the nitrogen can meet the medicinal requirement of the powder injection, for example, the pore diameter of the filter is less than or equal to 0.22 micron.

The conveying unit controls the transmission path of the nitrogen gas, can play the roles of buffering pressure, dividing and distributing, and conveys the nitrogen gas passing through the filter to the air inlet 1016 of the nitrogen sealing part 1 at a designated position.

The nitrogen sealing part 1 is arranged above the medicinal bottle and used for filling nitrogen. The nitrogen sealing part 1 comprises a first nitrogen sealing part 101 and a second nitrogen sealing part 102, the internal and external structures of the first nitrogen sealing part 101 and the second nitrogen sealing part 102 are preferably the same, and the length of the second nitrogen sealing part 102 is larger than that of the first nitrogen sealing part 101.

In the split charging process of the powder injection preparation, the medicinal bottles are arranged on a track corresponding to the split charging device and move forwards along with the track transmission, and the medicinal bottles sequentially pass through the first nitrogen sealing part 101, the powder discharging device, the second nitrogen sealing part 102 and the cork pressing device. The powder discharging device is used for quantitatively subpackaging the medicinal bottles, the cork pressing device is used for capping the medicinal bottles, the first nitrogen sealing part 101 is used for filling nitrogen into empty medicinal bottles, and the second nitrogen sealing part 102 is used for filling nitrogen into the medicinal bottles after powder injection preparation subpackaging.

The utility model discloses in, in the direction of transmission of medicinal bottle, first nitrogen part 101 that seals sets up before lower powder device, second nitrogen part 102 sets up before the tamponade device. Before powder discharging, the first nitrogen sealing part 101 is used for filling nitrogen into the empty medical bottle, so that the powder injection preparation is in a nitrogen environment when entering the medical bottle, the powder injection preparation which is subpackaged into the medical bottle is in the nitrogen environment, and particularly the powder injection preparation subpackaging amount of the specification of 1.5g and more than 1.5g is larger, the loose powder occupies a larger volume in the bottle, and the operation can reduce the air brought by the powder; before the tamponade, the medicine bottle filled with the powder injection preparation is filled with nitrogen again through the second nitrogen sealing part 102, as shown in fig. 1.

The first nitrogen sealing part 101 is a linear part and is arranged along the track direction of the conveying unit, and is provided with a top wall 1011, a bottom wall 1012 and a side wall 1013, and a hollow cavity 1014 is formed in the first nitrogen sealing part 101 in a hollow mode, as shown in fig. 2 and 3.

First nitrogen sealing component 101 preceding terminal surface includes inclined plane 1017, it is the setting of more than or equal to 90 degrees with the minimum positive contained angle of horizontal plane to go up inclined plane 1017, it is clockwise contained angle to go up inclined plane 1017 and the positive contained angle of horizontal plane, preferably parallel with the tangent plane that corresponds tamponade device department.

Preferably, the front end face of the first nitrogen sealing part 101 further comprises a lower inclined surface 1018, and the counterclockwise included angle θ from the upper inclined surface 1017 to the lower inclined surface 1018 is 30-270 degrees, preferably 35-160 degrees, and more preferably 40-50 degrees.

By arranging the front end face of the first nitrogen sealing part 101, the air outlet 1015 can be extended forwards, nitrogen flows to the capping and plugging station of the medicinal bottle of the cork pressing device, the coverage range of nitrogen atmosphere is extended as much as possible, the probability that air enters the medicinal bottle again when the medicinal bottle moves out of the coverage range of the air outlet 1015 and enters the processing range of the cork pressing device is reduced, and the structure of the included angle between the upper inclined plane 1017 and the lower inclined plane 1018 is shown in fig. 4.

The side wall 1013 is provided with a plurality of air inlets 1016 which are in a point distribution type; the gas inlets 1016 are disposed on one or both sidewalls 1013, and preferably, the gas inlets 1016 are equally spaced on the sidewalls 1013. After entering the hollow chamber 1014 along the inlet 1016 and impacting the inner side wall 1013, the nitrogen with pressure is mixed with the nitrogen delivered by other inlets 1016 uniformly and flows out along the outlet 1015, so that the flow diffusion surface and the flow pressure of the flowing nitrogen can be controlled more easily.

The first nitrogen sealing part 101 is provided with an air outlet 1015, and the air outlet 1015 penetrates through a lower inclined surface 1018 at the front end of the first nitrogen sealing part 101 and the tail end of the first nitrogen sealing part 101. In a preferred embodiment of the present invention, an air outlet 1015 is provided on the bottom wall 1012. The air outlet 1015 is in the shape of a slit, the front end of the air outlet 1015 penetrates through the lower inclined surface 1018 of the front end of the first nitrogen sealing part 101, and the rear end of the air outlet 1015 extends to a position adjacent to the rear end of the first nitrogen sealing part 101 and penetrates through the bottom wall 1012, as shown in fig. 2. The medical bottles move along the air outlet 1015 in a linear arrangement mode, the air outlet 1015 can continuously fill nitrogen into the medical bottles, and compared with the point intermittent nitrogen filling treatment, the air discharging effect in the medical bottles is better.

Preferably, the gas outlet 1015 vertically penetrates through the bottom wall 1012, so that the nitrogen in the hollow chamber 1014 can flow out in the shortest path, and the loss of the nitrogen charging pressure is reduced.

In one embodiment of the present invention, the front end surface of the hollow chamber 1014 has the same shape as the front end surface of the first nitrogen sealing member 101. The nitrogen in the hollow cavity 1014 can be converged and enter the air outlet 1015, the flow rate of the nitrogen flowing out of the air outlet 1015 is improved, a better nitrogen filling effect is achieved, and the utilization rate of the nitrogen is improved. When the nitrogen is flushed out from the air outlet 1015 of the lower inclined surface 1018 at the front end of the first nitrogen sealing part 101, the diffusion surface of the outflowing nitrogen is favorably expanded, so that the medical bottle has a nitrogen atmosphere in a larger range.

The utility model provides an among the embodiment, go up inclined plane 1017 and be 180 degrees to the anticlockwise contained angle of lower inclined plane 1018, for the horizontal plane, when keeping the basic perpendicular setting, the nitrogen gas wind speed that flows in and flow out gas outlet 1015 is controlled more easily, more does benefit to workshop production and operation.

The hollow chamber 1014 includes at least two separate compartments, each compartment having at least one inlet 1016.

In a preferred embodiment of the present invention, an inner partition wall is disposed in the hollow chamber 1014 between the first air inlet and the second air inlet, and the inner partition wall is connected to the top wall 1011, the bottom wall 1012, and the side wall 1013 to separate the first stage compartment 141. The first inlet is a first inlet arranged near the front end of the first nitrogen sealing part 101, the second inlet is adjacent to the first inlet, and the first inlet is communicated with the first section compartment 141. Adjacent to the first stage compartment 141 is a second stage compartment 142.

In a preferred embodiment of the present invention, the front end width of the first-stage compartment 141 is smaller than the rear end width thereof, and if the front end width of the first-stage compartment 141 is 1/2-2/3 of the rear end width thereof, the front end of the first-stage compartment 141 is preferably processed into an arc shape to reduce the impact damage of nitrogen gas to the nitrogen sealing member 1, as shown in fig. 5.

In the existing production equipment, in order to improve the nitrogen filling effect and reduce the residual oxygen, the aperture of the air outlets arranged in a point shape is generally larger and is basically not less than 4mm, so the filling pressure of nitrogen is also improved and is generally not less than 0.35 MPa. The pressure is large, the aperture is large, and the waste is very serious when the nitrogen packaging is carried out on the medicinal bottle.

In a preferred embodiment of the present invention, the gas outlet 1015 is slit-shaped and is disposed on the bottom wall 1012 to continuously fill nitrogen into the moving medical bottle. And the design of the first compartment 141 is utilized to extrude the nitrogen in the first compartment 141, so that the pressure of the nitrogen at the air outlet 1015 is increased, and therefore, a good nitrogen charging effect can be achieved without setting a large outlet width and a large nitrogen charging pressure. Wherein the moving direction of the medicine bottle is as shown by the arrow in figure 1, and the medicine bottle moves towards the cork pressing device.

The width of the air outlet 1015 is 1-3.5 mm, preferably 1-3.0 mm, more preferably 1.5-2.5 mm, such as 1.8 or 2 mm. Preferably, the width of the gas outlet 1015 at the first compartment 141 is 0.8-3mm, preferably 1.2-2.5, more preferably 1.5-1.8 mm.

It has also been found that the length of the outlet path of the vent 1015 affects the diffusion surface of the nitrogen gas. After the nitrogen gas flows out from the air outlet 1015, the nitrogen gas forms an air curtain to flow into the medicine bottle below the air outlet 1015 due to the slit-shaped outlet, and the air is discharged from the medicine bottle. When the nitrogen moves downwards, the diffusion surface of the nitrogen gradually becomes larger, so that the extrusion effect of the nitrogen airflow on the air in the medicinal bottle is weakened, and the nitrogen filling effect is reduced.

Further research shows that when the length of the outflow path of the air outlet 1015 is too short, the nitrogen airflow maintaining distance is short, the diffusion surface is large, and the residual oxygen amount is too high; when the outflow path is too long, the maintaining distance of the nitrogen airflow is lengthened, but the powder in the medicinal bottle is easy to fly, so that the content of the subpackaged medicines is not uniform; cleanliness in the plant may also be affected.

Since the gas outlet 1015 penetrates through the bottom wall 1012, the thickness of the bottom wall 1012 directly affects the outflow path length of the nitrogen gas, and when the gas outlet 1015 vertically penetrates through the bottom wall 1012, the thickness of the bottom wall 1012 is the outflow path length of the gas outlet 1015. Preferably, the length of the outlet path of the air outlet 1015 is 6-12 mm, and more preferably 8-10 mm.

The first nitrogen sealing part 101 or the second nitrogen sealing part 102 is suitable for a medicinal bottle with the volume of more than or equal to 5 ml. Preferably, the medicinal bottle comprises a vial of penicillin.

Accordingly, the pressure of the nitrogen gas is reduced to 2.0 to 4.5 kPa, preferably 2.0 to 3 kPa, so that the nitrogen gas can be filled into the bottom end of the interior of the medicine bottle and the medicine powder can be prevented from being blown up.

When the first nitrogen sealing part 101 or the second nitrogen sealing part 102 is used for filling nitrogen into the medicine bottle, the air outlet 1015 is downwards placed to be aligned with the bottle mouth of the medicine bottle, and the air outlet 1015 should be basically positioned in the middle of the bottle mouth of the medicine bottle so as to enable the medicine bottle to be uniformly filled with nitrogen. The height of the lower surface of the bottom wall 1012 from the opening of the medicinal bottle is 5mm or less, preferably 3mm or less, at the time of nitrogen charging.

The utility model discloses an in the preferred embodiment, the utility model discloses a nitrogen charging device is filled in powder injection preparation partial shipment can also be used to aseptic partial shipment process of aseptic powder injection preparation, realizes the powder injection preparation partial shipment of high quality, low residual oxygen.

Due to the requirement of sterility of powder injection preparation, a local A-grade clean environment needs to be maintained in a GMP production workshop to complete the sub-packaging, nitrogen filling and capping treatment. And a vertical external air flow with the air speed and pressure meeting GMP requirements from top to bottom is arranged in the A-grade clean environment.

Because the flow direction of the external vertical airflow is the same as that of the nitrogen airflow, the external vertical airflow and the nitrogen airflow can flow into the medical bottle together with the nitrogen during nitrogen filling, and the nitrogen filling effect is reduced. In addition, the vertical laminar flow can also impact the top wall 1011 in the first nitrogen sealing part 101 or the second nitrogen sealing part 102 and flow downwards along the two sides of the first nitrogen sealing part 101 or the second nitrogen sealing part 102 to interfere with the nitrogen charging airflow. To avoid the influence of vertical laminar flow, the upper surface of the top wall 1011 is preferably planar to maximize the change in the direction of the external vertical airflow.

Preferably, the width of the top wall 1011 is larger than the width of the body of the medicinal bottle, so that external vertical airflow can be effectively prevented from directly flowing into the medicinal bottle; more preferably, the width of the top wall 1011 is 1.5 to 2.5 times, for example, 2 times the width of the body of the medicinal bottle.

In addition, the research also finds that the longer the length of the first nitrogen sealing part 101 or the second nitrogen sealing part 102 is, the better the nitrogen filling effect of the medicinal bottle is; but when the length reaches a certain degree, the nitrogen filling effect of the medicinal bottle can not be improved. Preferably, the length of the first nitrogen sealing part 101 is not less than 10cm, preferably 10-30 cm, more preferably 14-25 cm, for example 17 cm.

The length of the second nitrogen sealing part 102 is not less than 20cm, preferably 20-50 cm, and more preferably 25-40 cm. Preferably, after the powder injection medicament is filled in the medicine bottle, the medicine bottle moves forwards to enter the lower part of the air outlet 1015 of the second nitrogen sealing part 102. The internal and external structures of the second nitrogen sealing part 102 are the same as those of the first nitrogen sealing part 101.

In a preferred embodiment of the present invention, the baffle 2 is disposed along the two vertical rails on the two sides of the rail of the bottle conveying unit, and the two sides of the baffle 2 face the bottle, as shown in fig. 3, preferably, the height of the baffle 2 is 2-3mm higher than the height of the bottle.

During nitrogen filling, the nitrogen gas in the medicine bottle is continuously pressed into the medicine bottle to replace the air in the bottle from the nitrogen gas curtain formed by the air outlet 1015 of the second nitrogen sealing part 102 to the completion of the corking process, so that the purity of the nitrogen gas is higher and higher. The nitrogen is blocked in a certain range by matching with the baffle 2, so that the outside of the bottle mouth of the medicine bottle is also in the nitrogen environment, and the nitrogen in the bottle starts to be pressed and plugged immediately when reaching a certain purity. And leaving the nitrogen protection area after the completion of the tamponade.

Preferably, the bottom end of the baffle 2 is also vertically provided with an extension part outwards, and the extension part is connected with the conveying track of the medicine bottle through a fastening device, so that a nitrogen atmosphere is formed in the baffle 2; the extrusion effect of the air in the medicinal bottle in the limited space is improved through the continuous filling of the nitrogen.

Considering the requirement of GMP in the pharmaceutical field on the cleanliness of a sterile subpackaging workshop and the requirement of materials of production equipment, the nitrogen sealing part 1 is preferably made of stainless steel, particularly 316 stainless steel, so that the influence of the preparation materials of the nitrogen filling device on the nitrogen cleanliness can be reduced.

Accordingly, the intake pipe of the delivery unit is made of the same metal material as the nitrogen sealing part 1, preferably 316 stainless steel.

The air inlet pipe of the conveying unit is fixedly connected with the air inlet 1016 of the nitrogen sealing part 1, and is in any one of welding connection, threaded connection and sticking connection, and is preferably fixed through welding or threaded connection.

The utility model provides an among the nitrogen charging device, first nitrogen sealing part 101 fills the nitrogen to the medicinal bottle before lower powder, make under the powder injection preparation get into nitrogen atmosphere in the medicinal bottle after the powder partial shipment, reduce the entering of powder injection preparation carried air, second nitrogen sealing part 102 can guarantee to obtain effectively filling nitrogen before the medicinal bottle tamponade, has improved and has filled nitrogen efficiency, has further reduced the residual oxygen volume, makes the residual oxygen volume reduce to below 1%, has effectively prolonged the medicine save time. And the waste of nitrogen is reduced, the blowing-out of the powder injection preparation is avoided, and the production cost of the powder injection preparation is reduced.

In the description of the present invention, it should be noted that the terms "upper", "lower", "inner", "outer", "front", "rear", and the like indicate the directions or positional relationships based on the operating states of the present invention, and are only for convenience of description and simplification of the description, but do not indicate or imply that the device or element indicated must have a specific direction, be constructed and operated in a specific direction, and thus should not be construed as limiting the present invention.

The invention has been described in detail with reference to specific embodiments and/or illustrative examples and the accompanying drawings, which, however, should not be construed as limiting the invention. Those skilled in the art will appreciate that various equivalent substitutions, modifications or improvements may be made to the technical solution of the present invention and embodiments thereof without departing from the spirit and scope of the present invention, and all fall within the scope of the present invention. The protection scope of the present invention is subject to the appended claims.

Claims (10)

1. The split charging and nitrogen filling device for the powder injection is characterized by comprising a nitrogen storage unit, a control valve, a filter, a conveying unit and a nitrogen sealing part (1);

the nitrogen sealing part (1) comprises a first nitrogen sealing part (101) and a second nitrogen sealing part (102);

in the transmission direction of the medicine bottle, the first nitrogen sealing part (101) is arranged in front of the powder discharging device, and the second nitrogen sealing part (102) is arranged in front of the tamponade device.

2. The nitrogen charging device according to claim 1, wherein the first nitrogen sealing part (101) is a linear part and is arranged along the track direction of the conveying unit, and a hollow chamber (1014) is formed in the first nitrogen sealing part (101) in a hollow mode.

3. A dosing device according to claim 2, characterized in that said hollow chamber (1014) comprises at least two separate compartments, each compartment being provided with at least one inlet opening (1016).

4. A dosing device according to claim 3, characterized in that the first compartment (141) has a front width smaller than a rear width.

5. The nitrogen charging device as claimed in claim 4, wherein the width of the front end of the first compartment (141) is 1/2-2/3 of the width of the rear end thereof, and the front end of the first compartment (141) is formed in a circular arc shape.

6. Nitrogen charging device according to claim 1,

the front end face of the first nitrogen sealing component (101) comprises an upper inclined plane (1017), and the minimum positive included angle between the upper inclined plane (1017) and the horizontal plane is greater than or equal to 90 degrees;

the front end face of the first nitrogen sealing component (101) further comprises a lower inclined face (1018), and the counterclockwise included angle from the upper inclined face (1017) to the lower inclined face (1018) is 30-270 degrees.

7. Nitrogen charging device according to claim 6,

the first nitrogen sealing part (101) is provided with an air outlet (1015), and the air outlet (1015) penetrates through a lower inclined plane (1018) at the front end of the first nitrogen sealing part (101) and the tail end of the first nitrogen sealing part (101).

8. Nitrogen charging device according to claim 7, characterized in that the gas outlet (1015) is slit-shaped.

9. Nitrogen charging device according to claim 7,

when the first nitrogen sealing part (101) or the second nitrogen sealing part (102) is used for filling nitrogen into the medicine bottle, the air outlet (1015) is downwards placed to be aligned with the bottle mouth of the medicine bottle;

baffle plates (2) are arranged along the vertical rails at the two sides of the rail of the medicinal bottle conveying unit, and the surfaces of the baffle plates (2) at the two sides face the medicinal bottles.

10. The nitrogen charging device according to any one of claims 1 to 9, wherein the second nitrogen sealing member (102) has the same inner and outer structure as the first nitrogen sealing member (101), the length of the first nitrogen sealing member (101) is not less than 10cm, and the length of the second nitrogen sealing member (102) is not less than 20 cm.

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