CN214908608U - Rat and mouse trachea instillation device - Google Patents

Abstract

The utility model discloses a rat and mouse trachea instillation device, which comprises an operation table top, an upper incisor fixing mechanism and a lower incisor fixing mechanism, wherein the upper incisor fixing mechanism comprises an upper incisor fixing nail and an upper incisor pulley which are arranged and fixed at the left end and the right end of the operation table top; lower incisor teeth fixed establishment is located go up incisor teeth fixed establishment's lower part and including setting up the lower incisor teeth staple and the lower incisor teeth pulley at both ends about the operation mesa, lower incisor teeth staple with operation mesa fixed connection be provided with the slide that sets up along upper and lower direction on the operation mesa, the slide internal slip is established incisor teeth pulley down, incisor teeth staple department is connected with lower incisor teeth fixed line down, lower incisor teeth fixed line is walked around be connected with lower incisor teeth counter weight behind the lower incisor teeth pulley.

Description

Rat and mouse trachea instillation device

Technical Field

The utility model relates to a big mouse trachea instillation device and a small mouse trachea instillation device.

Background

Respiratory tract exposure is an important exposure way in the scientific research fields of toxicology, clinical medicine and the like, during research, respiratory tract contamination and drug administration are required more and more, and tracheal instillation is a common drug administration and contamination method in respiratory tract exposure research. The trachea instillation comprises non-exposure type trachea instillation and exposure type trachea instillation, the exposure type trachea instillation is to expose the trachea of an animal in an operation mode, the trachea instillation operation is carried out, and the non-exposure type trachea instillation is to directly perform trachea cannula instillation. The tracheal instillation has the advantages of stability, easiness in determining exposure and the like, and although the natural inhalation exposure method is increasingly used, the tracheal instillation method still has a large demand space due to the problems that exposure equipment is expensive, the exposure dose is difficult to evaluate and the like. As research progresses, the need for repeated tracheal instillations will increase as research on repeated exposure designs can provide more consistent results. The mouse is the most widely used animal in experimental animals and is also used in respiratory system exposure research in a large number, but because of the special oropharyngeal structure of the mouse, the tracheal instillation on the mouse has certain difficulty, and the exposed tracheal instillation can only be operated once, so the requirement of the research design of repeated respiratory tract exposure will put higher requirements on the repeated non-exposed tracheal instillation on the mouse. At present, no reliable and efficient mouse non-exposure type tracheal instillation equipment exists.

Chinese patent CN209827080U discloses a fixing device for non-exposed tracheal instillation for laboratory mice, and specifically discloses: the mouse fixing device comprises a rectangular acrylic plate a and a base b, wherein a string 1 is arranged at the upper end of the rectangular plate and used for hanging upper incisors of a laboratory mouse, and a rubber band is arranged at the lower end of the rectangular plate and used for fixing the body of the rat. Also comprises an oval ring for opening and fixing the oral cavity of the experimental mouse. The optimal included angle (alpha) between the rectangular plate and the horizontal plane is 80 degrees, and can be 75-85 degrees. The width and height of the rectangular plate are preferably 20cm and 30cm, the width can also be between 15 cm and 20cm, the height can also be between 25 cm and 30cm, the length of the base of the rectangular plate is between 15 cm and 20cm, and the width is between 6cm and 8 cm. The oral cavity fixer is an oval ring, and the diameters of the short side and the long side are 2cm and 4cm respectively.

However, the above patent only realizes the fixation of the mouse, and there is also unreliable fixation in the fixation, which cannot be applied to the mouse with various body types, and at least needs another person to cooperate, which takes 2 minutes to complete the operation. Low efficiency, low reliability and low safety.

SUMMERY OF THE UTILITY MODEL

The utility model aims to provide a big mouse trachea instillation device suitable for the mouse of various sizes.

In order to achieve the above object, the present invention provides: the utility model provides a big mouse trachea instillation device, includes the operation mesa, the inclination of operation mesa is adjustable, be provided with incisor fixing mechanism, lower incisor fixing mechanism on the operation mesa, its characterized in that: the upper incisor tooth fixing mechanism comprises an upper incisor tooth fixing nail and an upper incisor tooth pulley which are fixed at the left end and the right end of the operation table board, an upper incisor tooth fixing line is connected at the upper incisor tooth fixing nail, and an upper incisor tooth counter weight is connected after the upper incisor tooth fixing line bypasses the upper incisor tooth pulley; lower incisor teeth fixed establishment is located go up incisor teeth fixed establishment's lower part and including setting up the lower incisor teeth staple and the lower incisor teeth pulley at both ends about the operation mesa, lower incisor teeth staple with operation mesa fixed connection be provided with the slide that sets up along upper and lower direction on the operation mesa, the slide internal slip is established incisor teeth pulley down, incisor teeth staple department is connected with lower incisor teeth fixed line down, lower incisor teeth fixed line is walked around be connected with lower incisor teeth counter weight behind the lower incisor teeth pulley. Adopt above-mentioned structure, accessible counter weight and pulley adjustment go up the radian of incisor fixed line and incisor fixed line down to slide adjustable interval between incisor fixed line and the lower incisor fixed line in the slide through lower incisor pulley, make this device can be applicable to the mouse of different sizes.

For further convenience in operation, the rat and mouse trachea instillation device further comprises a trachea cannula and an instillation mechanism, the trachea cannula and the instillation mechanism comprise a hollow trachea cannula needle, the tail part of the trachea cannula needle is connected with a trachea cannula handle, the tail part of the trachea cannula handle is connected with a trachea cannula connecting pipe, and the tail end of the trachea cannula connecting pipe extends into a trachea cannula indicator; the trachea cannula needle is detachably connected with the trachea cannula handle, and the tail part of the trachea cannula needle can be connected with a liquid injector.

Preferably, a bend is arranged at a position of 1.2-2.0cm away from the front section of the tracheal intubation needle, and an included angle of 15 degrees is formed between the front section and the rear section.

Preferably, a smooth clip is arranged at a position 0.7-1.2cm away from the tip of the needle head of the tracheal intubation needle, and the clip has the diameter of 2-3mm and the length of 4 mm.

Preferably, the endotracheal intubation indicator includes a transparent cylindrical container, and the cylindrical container contains colored indicating liquid. The top end of the cylindrical container is provided with an opening to ensure the balance of the air pressure inside and outside the container.

For further convenient operation, big mouse trachea instillation device still includes LDE transmission lamp, the LED transmission lamp is installed through adjustable return bend on the operation mesa.

For further facilitating the fixation of the mouse, a mouse outline groove is arranged in the middle of the operation table top.

Preferably, the bottom edge of the operation table surface is provided with a collecting groove for collecting excrement and urine.

Has the advantages that:

1. the device of the utility model can fix big and small mice, adjust the positions of the corresponding counter weight and the lower incisor pulley in the slideway according to the difference of the animal weight, thus achieving the purpose of fixing animals, not damaging the animals and having simple and convenient operation;

2. the utility model discloses a trachea cannula part of device comprises trachea cannula needle, trachea cannula handle, trachea cannula connecting pipe and trachea cannula indicator, whether trachea cannula indicator can objective reflection trachea cannula succeed to the success rate that the trachea instiled has been guaranteed. The connecting size of the tracheal intubation needle is matched with that of a common injector, after the tracheal intubation is successful, the handle of the tracheal intubation can be pulled out, the injector is connected with the tracheal intubation needle, and the operation of tracheal instillation is completed. Convenient and rapid operation, short time consumption and high success rate.

Drawings

FIG. 1 is a view showing the construction of a rat and rat tracheal instillation device in the embodiment (the direction of the arrow is the direction of air flow);

FIG. 2 is a right side view of the work table of embodiment 1;

FIG. 3 is a front view of the table top of example 1 (with upper and lower incisor securing mechanisms);

FIG. 4 is a front view of the work table of example 1 (with an LED transmission lamp);

FIG. 5 is a front view of the operating table of example 1 (with the anaesthetic mask mechanism);

FIG. 6 is a view showing the structure of the syringe and the endotracheal tube needle in example 1.

Detailed Description

The following detailed description of the embodiments of the present invention will be made with reference to the accompanying drawings, but the present invention is not limited to these embodiments, and any modifications or replacements within the basic spirit of the embodiments still fall within the scope of the present invention claimed in the claims.

Example (b): as shown in fig. 1-6, the present embodiment provides a rat and mouse trachea instillation device, which comprises an operation table 100, wherein the inclination angle of the operation table is adjustable. Specifically, the method comprises the following steps: including a base 101 that can arrange the mesa in, set up support frame 102 on the base, set up on the support frame the operation mesa, the back of operation mesa with the support frame support is provided with coupling mechanism 103, coupling mechanism sets up to adjustable form, makes the operation mesa can follow coupling mechanism rotates and then adjusts the angle of operation mesa, wherein, coupling mechanism can be for the face gear or the checkpost mechanism of mutually supporting, and this is prior art, and no longer repeated here.

In addition, the bottom surface of the operation table top can be connected with the front end of the base, and the angle adjustment of the operation table top is realized through the connection structure of the front section of the base and the bottom surface of the operation table top.

In the embodiment, the former arrangement is selected, the size of the operation table is set to be 25 × 50cm, and the bottom edge of the operation table is provided with a collecting groove 104 for collecting excrement and urine. The collecting vat is upwards open-ended U-shaped, and both ends are sealed, will a side of the collecting vat of U-shaped with the connection can be dismantled to operation mesa's base, this will the collecting vat with operation mesa bottom is provided with magnetism and inhales the formula fixed, convenient to detach and clearance.

In addition, be provided with the mechanism that is used for fixed mouse on the operation mesa, including four limbs fixed establishment, upper incisor fixed establishment and lower incisor fixed establishment, wherein, four limbs fixed establishment is unanimous with prior art, and no longer gives details here. The upper incisor fixing mechanism comprises an upper incisor fixing nail 201 and an upper incisor pulley 202 which are fixed at the left end and the right end of the operation table board, an upper incisor fixing line 203 is connected at the upper incisor fixing nail, and an upper incisor counter weight 204 is connected after the upper incisor fixing line winds around the upper incisor pulley; lower incisor tooth fixed establishment is located go up incisor tooth fixed establishment's lower part and including setting up the lower incisor staple 205 and the lower incisor pulley 206 at both ends about the operation mesa, lower incisor staple with operation mesa fixed connection be provided with the slide 207 that sets up along upper and lower direction on the operation mesa, the slide internal slip is established incisor tooth pulley down, incisor staple department is connected with lower incisor tooth fixed line 208 down, lower incisor tooth fixed line walks around be connected with lower incisor tooth counter weight 209 down behind the lower incisor tooth pulley.

In this embodiment, the fixing nails of the upper front tooth fixing mechanism and the fixing nails of the lower front tooth fixing mechanism are respectively arranged at the left side and the right side of the operation table-board, and the upper front tooth pulley and the upper front tooth counter weight of the upper front tooth fixing mechanism and the lower front tooth pulley and the lower front tooth counter weight of the lower front tooth fixing mechanism are respectively arranged at the left side and the right side of the operation table-board.

In this embodiment, the weight may be a metal block or other object with a higher density, and the weight may have multiple specifications for overlapping use. To adapt to mice of different sizes.

In addition, as another embodiment in the present embodiment, a mouse contour groove 105 for housing a mouse is provided in the middle of the operation table. The profile size of the mouse profile groove is set to be larger as much as possible, so that the mouse profile groove can be suitable for mice with different head volumes.

In addition, the tracheal instillation device for rats and mice in the embodiment further comprises a negative pressure tongue depressing mechanism, the negative pressure tongue depressing mechanism comprises a hollow tongue spatula 301, the tail end of the tongue spatula is connected with a hollow tongue spatula handle 302, the tail end of the tongue spatula handle is connected with a negative pressure suction tube 303, and the negative pressure suction tube is connected with a liquid collecting bottle 304; the negative pressure air pump 305 is further included, the air pump is connected with the liquid collecting bottle, and a microswitch 306 for starting the air pump is arranged on the handle. In this embodiment, the micro switch is located at the rear third of the grip, so that the operator can conveniently hold and operate the micro switch. And the front end of the tongue depressor is an oval opening, so that the tongue depressor can be used as the tongue depressor to jack up the tongue of an animal, and the oropharynx secretions in the deep part of the oral cavity can be sucked out, so that the trachea opening is better exposed. In addition, the tongue depressor is provided with a bending part, the included angle between the front tongue depressor and the rear tongue depressor at the bending part is 20-30 degrees, and the included angle between the front tongue depressor and the rear tongue depressor in the embodiment is 25 degrees.

In addition, the rat and rat trachea instillation device in the embodiment further comprises a trachea cannula and an instillation mechanism, and the trachea cannula and the instillation mechanism in the embodiment can realize the functions of inserting into the trachea and instilling into the trachea. Specifically, the method comprises the following steps: the trachea cannula and instillation mechanism comprises a hollow trachea cannula needle 401, the tail part of the trachea cannula needle is connected with a trachea cannula handle 402, the tail part of the trachea cannula handle is connected with a trachea cannula connecting pipe 403, and the tail end of the trachea cannula connecting pipe extends into a trachea cannula indicator; the trachea cannula needle is detachably connected with the trachea cannula handle, and the tail part of the trachea cannula needle can be connected with a liquid injector. Trachea cannula and drip mechanism still includes LDE transmission lamp 405, LED transmission lamp is installed through adjustable return bend 406 on the operation mesa. The bent pipe can adopt angle-adjustable bent pipes such as a steel screw rod.

Wherein, mouse trachea cannula needle diameter 0.7mm, metal syringe needle length 3.0cm, the front end is smooth, and is provided with the bending in anterior segment 1.2cm department of metal syringe needle, and anterior segment and back end form 15 contained angles. The trachea cannula needle is provided with a smooth clip 407 at a position 0.7cm away from the tip of the needle head, wherein the diameter of the clip is 2mm, and the length of the clip is 4 mm. The endotracheal intubation indicator includes a transparent cylindrical container 404 with an open upper end and a volume of 5ml, and the transparent cylindrical container contains colored indicating liquid, for example, red indicating liquid, and the volume of the indicating liquid is 3 ml. The trachea cannula connecting pipe is inserted into the cylindrical container from the top of the cylindrical container, and the insertion indicating liquid opening of the trachea cannula connecting pipe is 1cm below the liquid level of the indicating liquid. The top end of the cylindrical container is provided with an opening to ensure the balance of the air pressure inside and outside the container.

When the experimental animal is a rat, the diameter of the tracheal intubation needle of the rat is 1.2mm, the length of the metal needle is 6cm, the front end of the metal needle is smooth, a bend is arranged at the 2.0cm position of the front section of the metal needle, and the front section and the rear section form an included angle of 15 degrees. The trachea cannula needle is provided with a smooth clip 407 at a position 1.2cm away from the tip of the needle head, wherein the diameter of the clip is 3mm, and the length of the clip is 4 mm. The other steps were essentially the same as for mice.

After the animal (mouse) is anesthetized, after the animal (mouse) is fixed on an operation table, the left hand holds the negative pressure tongue depressor to clean oral secretion, the tongue is slightly picked up to expose the oropharynx, a small flickering spot which appears in the deep part of the oropharynx along with the respiration of the animal can be seen, the brightening spot is the opening part of a trachea, the tracheal intubation needle is connected with the tracheal intubation handle, the right hand holds the tracheal intubation handle, the bent concave surface of the tracheal intubation needle faces to the ventral side of the animal, when the flickering of the opening part of the trachea is seen, the tracheal intubation needle is inserted from the brightening spot, the clip at the front end of the tracheal intubation needle is just clamped at the opening part of the trachea of the small animal, whether the liquid level in the tracheal intubation connecting tube in the tracheal intubation indicator fluctuates up and down along with the respiration of the small animal or not is immediately observed, the fluctuation can determine that the tracheal intubation needle is correctly inserted into the trachea of the animal, and the tracheal intubation needle can be stabilized by the left hand, then, the endotracheal tube grip is pulled out, the syringe 408 is used to suck the required liquid, and the syringe and the endotracheal tube needle are connected, so that the operation of the endotracheal instillation can be performed.

As another implementation manner in this embodiment, an anesthetic mask mechanism is further disposed on the top of the operation table, and the anesthetic mask mechanism includes an anesthetic mask 501, and the anesthetic mask is connected to an anesthetic line 502. And the bottom end of the anaesthetic mask is lower than the upper incisor fixing line, specifically, the bottom end of the anaesthetic mask is lower than the upper incisor fixing line by 0.5 cm. The operating table top is provided with a groove 105 for an anesthesia mask and a pipeline, and a depression 106 is also arranged at the contact position of the anesthesia machine pipeline and the operating table, so that the pipeline does not protrude too much, and the sight of an operator is not obstructed. The opening 503 of the anaesthetic mask is made of soft rubber, and the center of the opening is eccentrically arranged forwards. The part of the mask which is not opened is embedded in the operating platform, the opening of the anaesthetic mask is flush with the operating platform, the front end of the head and the nose of a mouse can be clamped in the anaesthetic mask, and the air tightness of the anaesthetic mask combined with an animal and the fact that the mask does not protrude out of the platform surface to cause the sight obstruction are ensured.

The device of this embodiment both can be used for gas anesthesia and also can be used for injecting the animal of anesthesia and carry out the trachea instillation operation, and fixed anesthesia machine face guard operates when carrying out gas anesthesia, and it can to take off anesthesia face guard mechanism when the mouse adopts the injection anesthesia. Can change the anaesthetic mask with different specifications openings according to the size of the mouse body.

As another implementation of this embodiment, still hang on the operation mesa and be equipped with tweezers and tongue clamp, tweezers and tongue clamp front end all can twine soft cloth, can guarantee not to harm the animal, when using gaseous anesthesia, accomplish to transfer the animal to the operation panel after induced anesthesia fast, fill in the anaesthetic mask with the nose of animal, fix the last front tooth with last front tooth fixed line, then fix the lower front tooth with lower front tooth fixed line, then fix four limbs, after fixing well pull out the tongue of animal gently with tweezers, clip the tongue gently with the tongue clamp, make the tongue of animal draw to one side. The upper incisor fixing line and the lower incisor fixing line are smooth flexible wires, so that the upper incisor fixing line just clamps the nose of the animal in the anaesthetic mask, and the lower incisor fixing line exposes the oral cavity of the animal, so that the animal cannot be damaged.

In addition, a power supply is also arranged and supplies power to the LED transmission lamp and the microswitch. A power switch may be provided on the base.

In addition, this example provides an operation method based on the rat and mouse tracheal instillation device:

step one, a regulating device: the weight of the upper front tooth counter weight and the weight of the lower front tooth counter weight are adjusted according to the size of the animal, and the distance between the lower front tooth fixing line and the upper front tooth fixing line is adjusted through the sliding rail. If the animal is anesthetized by gas, the mask of the anesthesia machine is required to be fixed on the operating platform, and if the animal is anesthetized by injection, the mask of the anesthesia machine is not required to be installed; turning on power supplies of the LED transmission lamp and the negative-pressure tongue depressor;

secondly, fixing the mice: after the rats are anesthetized, the animals are quickly transferred to an operation table, the nose parts of the animals are plugged into an anesthetic mask, upper incisors are fixed by upper incisor fixing lines, lower incisors are fixed by lower incisor fixing lines, four limbs are fixed, after the animals are fixed, the tongues of the animals are slightly pulled out by tweezers, and the tongues are slightly clamped by tongue clamps to enable the tongues of the animals to be pulled to one side; adjusting the bent tube of the LED lamp to enable the light to be vertically incident from the neck of the animal; (gas anesthesia is divided into induction anesthesia and maintenance anesthesia, the induction anesthesia is completed in an induction box, the maintenance anesthesia provides anesthesia gas for an anesthesia machine mask on an operation table, the injection anesthesia is generally intraperitoneal injection, and the injection is only needed after the injection);

thirdly, clearing oropharynx secretions and exposing visual field: an operator is positioned at the rear side of the device, holds the negative-pressure tongue depressor by the left hand, the forefinger is arranged on the microswitch, the tongue depressor is stretched into the oral cavity of an animal, the tongue of the animal is lifted forwards, the oropharynx part is exposed, the forefinger presses the microswitch, the air pump starts to work, negative pressure is generated in the negative-pressure suction tube, the tongue depressor sucks the oropharynx secretions to the negative-pressure liquid collecting bottle through the negative-pressure suction tube, a twinkling small bright spot can be seen in the deep part of the oropharynx along with the breathing of the animal, the bright spot is the opening of the trachea, and the cleaning of the oral secretions can be completed immediately;

step four, trachea intubation and instillation: holding the negative-pressure tongue depressor by the left hand to maintain the previous operation, keeping the exposure of the opening of the trachea, connecting the tracheal cannula needle with the tracheal cannula handle, holding the tracheal cannula handle by the right hand, enabling the curved concave surface of the tracheal cannula needle to face the ventral side of the animal, inserting the tracheal cannula needle from a bright spot when the opening of the trachea is observed to flicker, enabling a clamp at the front end of the tracheal cannula needle to be just clamped at the opening of the trachea of the small animal, observing whether the liquid level in the tracheal cannula connecting pipe in the tracheal cannula indicator fluctuates up and down along with the respiration of the small animal immediately, determining that the tracheal cannula needle is correctly inserted into the trachea of the animal by fluctuation, stabilizing the tracheal cannula needle by the left hand, pulling out the tracheal cannula handle, sucking required liquid by an injector, connecting the injector with the tracheal cannula needle, instilling the liquid into the trachea of the mouse, and finishing the operation of instilling the trachea, after instillation, the rat keeps the current body position for a plurality of seconds, gently massages the chest of the rat, and observes whether asphyxia exists or not;

and fifthly, after the instillation is finished, the tracheal intubation needle is pulled out, the tongue clamp is taken down, the upper and lower incisors and the four limbs are unfastened, and the mouse is placed on a constant temperature plate to wait for revival. The opening of the air outlet end of the air pump is matched with the tracheal intubation needle, so that the air pump can be used for cleaning the tracheal intubation needle and avoiding blockage.

The rat and rat tracheal instillation device and method of the embodiment are adopted: 1. the whole device can complete all operations by only one person, and has simpler operation and high success rate, which is superior to the prior art that the operation is matched by multiple persons.

2. The device can be used for small animal trachea instillation operation of gas anesthesia and injection anesthesia, can be used for small animal trachea instillation operation of gas anesthesia when installing the anesthesia machine face guard, can be used for the animal of injection anesthesia to operate when taking off the anesthesia machine face guard.

3. The fixing device of the device can fix rats and mice, and the positions of the corresponding counter weight and the lower incisor pulley in the slide way are adjusted according to the difference of the weight of the animals, so that the purpose of fixing the animals can be achieved, the animals are not damaged, and the operation is simple and convenient.

4. When the animal is in anesthesia oropharynx can have the secretion, and the secretion can obstruct operator's the field of vision, influences going on of operation, and it is not good to adopt the cotton swab to clear away oropharynx secretion effect in the past, and mouse oropharynx is less moreover, and the cotton swab is not suitable for the operation. The device uses the negative pressure tongue depressor to clear away the oropharynx secretion of animal, only need during the operation press the micro-gap switch on the handle can, clear away rapidly, effectual, also only need press the micro-gap switch again and can clear away when the secretion appears again in the operation process moreover, need not stop normal operation, and operating efficiency is high. When the microswitch is not pressed, the negative pressure tongue depressor can be used for picking up the tongue of the animal, so that the operation visual field is fully exposed.

5. The trachea cannula part of the device consists of a trachea cannula needle, a trachea cannula grip, a trachea cannula connecting pipe and a trachea cannula indicator, and the trachea cannula indicator can objectively reflect whether trachea cannula succeeds or not, so that the success rate of trachea instillation is ensured. The connecting size of the tracheal intubation needle is matched with that of a common injector, after the tracheal intubation is successful, the handle of the tracheal intubation can be pulled out, the injector is connected with the tracheal intubation needle, and the operation of tracheal instillation is completed. Convenient and rapid operation, short time consumption and high success rate.

Claims (8)

1. The utility model provides a big mouse trachea instillation device, includes the operation mesa, the inclination of operation mesa is adjustable, be provided with incisor fixing mechanism, lower incisor fixing mechanism on the operation mesa, its characterized in that:

the upper incisor tooth fixing mechanism comprises an upper incisor tooth fixing nail and an upper incisor tooth pulley which are fixed at the left end and the right end of the operation table board, an upper incisor tooth fixing line is connected at the upper incisor tooth fixing nail, and an upper incisor tooth counter weight is connected after the upper incisor tooth fixing line bypasses the upper incisor tooth pulley;

lower incisor teeth fixed establishment is located go up incisor teeth fixed establishment's lower part and including setting up the lower incisor teeth staple and the lower incisor teeth pulley at both ends about the operation mesa, lower incisor teeth staple with operation mesa fixed connection be provided with the slide that sets up along upper and lower direction on the operation mesa, the slide internal slip is established incisor teeth pulley down, incisor teeth staple department is connected with lower incisor teeth fixed line down, lower incisor teeth fixed line is walked around be connected with lower incisor teeth counter weight behind the lower incisor teeth pulley.

2. The rat and rat tracheal instillation device of claim 1, wherein: the trachea cannula and drip mechanism comprises a hollow trachea cannula needle, the tail of the trachea cannula needle is connected with a trachea cannula handle, the tail of the trachea cannula handle is connected with a trachea cannula connecting pipe, and the tail end of the trachea cannula connecting pipe extends into a trachea cannula indicator; the trachea cannula needle is detachably connected with the trachea cannula handle, and the tail part of the trachea cannula needle can be connected with a liquid injector.

3. The rat and rat tracheal instillation device of claim 2, wherein: a bend is arranged at a position 1.2-2.0cm away from the front section of the tracheal intubation needle, and an included angle of 15 degrees is formed between the front section and the rear section.

4. The rat and rat tracheal instillation device of claim 3, wherein: the trachea cannula needle is provided with a smooth clip at a position 0.7-1.2cm away from the tip of the needle head, and the clip has the diameter of 2-3mm and the length of 4 mm.

5. A rat and rat tracheal instillation device according to claim 2, 3 or 4, wherein the rat and tracheal instillation device comprises: the trachea cannula indicator comprises a transparent cylindrical container, wherein colored indicating liquid is contained in the cylindrical container, and an opening is formed in the top end of the cylindrical container.

6. The rat and rat tracheal instillation device of claim 5, wherein: still include LED transmission lamp, LED transmission lamp passes through adjustable return bend and installs on the operation mesa.

7. The rat and rat tracheal instillation device of claim 1 or 6, wherein the rat and tracheal instillation device comprises: a mouse profile groove is formed in the middle of the operating table top.

8. The rat and rat tracheal instillation device of claim 7, wherein: the bottom edge of the operation table top is provided with a collecting groove for collecting excrement and urine.

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