CN214810941U

CN214810941U - Environment-friendly ion exchange device for producing crude heparin sodium

Info

Publication number: CN214810941U
Application number: CN202023174986.4U
Authority: CN
Inventors: 崔洁; 孙云霞; 乔康康; 龚运舟
Original assignee: Hebei Changshan Kaikude Biotechnology Co Ltd
Current assignee: Hebei Changshan Kaikude Biotechnology Co Ltd
Priority date: 2020-12-25
Filing date: 2020-12-25
Publication date: 2021-11-23
Anticipated expiration: 2030-12-25

Abstract

The utility model discloses a production crude heparin sodium environment-friendly ion exchange device relates to crude heparin sodium production facility technical field. The utility model discloses an upper portion device, lower part device and maintenance device, the upper portion device mainly carries out ion exchange, washing and elution, and the lower part device mainly deposits, overhauls the device setting at the back of upper portion device and lower part device, and the primary function of overhauing the device is overhauld and is clean ion exchange device. The utility model discloses a part about setting up, going on in the upper portion device with ion exchange, washing and elution setting, will deposiing the setting and go on in the lower part device to ion exchange device's work efficiency has been increased, the utility model discloses a set up the access hole, can maintain and clear up ion exchanger through the access hole, its a plurality of fixing bolt carry out fixed seal, thereby also can be convenient when having guaranteed the leakproofness maintain and clear up the inside of ion exchanger.

Description

Environment-friendly ion exchange device for producing crude heparin sodium

Technical Field

The utility model belongs to the technical field of crude product heparin sodium production facility, especially, relate to an environment-friendly ion exchange device of production crude product heparin sodium.

Background

Ion exchange is the action or phenomenon of exchanging ions in solution with ions on certain ion exchanger, and is the aim of extracting or removing some ions in solution by means of exchanging ions in solid ion exchanger with ions in dilute solution, and is a unit operation belonging to mass transfer separation process.

Ion exchange is a reversible, equivalent exchange reaction. The ion exchange resin is filled and clamped between the anion exchange membrane and the cation exchange membrane to form a single processing unit and form a fresh water chamber. The ion exchange rate decreases with increasing degree of crosslinking of the resin and increases with decreasing particle size. Ion exchange is a liquid-solid phase reaction process that necessarily involves diffusion of species in both the liquid and solid phases. The crude heparin sodium can also be prepared by using an ion exchange method, but the existing crude heparin sodium ion exchange device has low efficiency, and the maintenance and cleaning of the existing crude heparin sodium ion exchange device are very inconvenient. Therefore, an environment-friendly ion exchange device for producing crude heparin sodium is needed to solve the problems.

SUMMERY OF THE UTILITY MODEL

An object of the utility model is to provide a production crude heparin sodium environment-friendly ion exchange device to current problem has been solved: the efficiency of current crude product heparin sodium ion exchange device is not high, and the maintenance clearance of current crude product heparin sodium ion exchange device is very inconvenient.

In order to solve the technical problem, the utility model discloses a realize through following technical scheme:

the utility model relates to a production crude heparin sodium environment-friendly ion exchange device, including upper portion device, lower part device and maintenance device, the upper portion device mainly carries out ion exchange, washing and elution, the lower part device mainly deposits, overhaul the back that the device set up at upper portion device and lower part device, the main effect of overhauing the device is overhauld and is clean ion exchange device.

Further, the upper portion device is provided with a feeding opening, one side of the feeding opening is provided with a hydrolysate injection opening, the other side of the feeding opening is provided with a dilute brine injection opening, one side of the upper portion device is provided with a clear water injection opening, the other side of the upper portion device is provided with a strong brine injection opening, and a water outlet is arranged below the strong brine injection opening.

Further, the upper device comprises an elution liquid pipe, a filter screen is arranged at the bottom of the elution liquid pipe, an upper motor is arranged on the side face of the upper device and connected with an upper stirring shaft, the upper stirring shaft is arranged in the upper device, an upper sight glass is arranged on the surface of the upper device, and an upper thermometer is arranged on the side edge of the upper sight glass.

Further, the lower device comprises an alcohol injection hole, an alcohol extraction hole is formed below the alcohol injection hole, a lower motor is arranged on the side face of the lower device, the lower motor is connected with a lower stirring shaft, the lower stirring shaft is arranged in the lower device, a lower sight glass is arranged on the surface of the lower device, and a lower thermometer is arranged on the side edge of the lower sight glass.

Further, the overhaul device comprises an overhaul cover, an overhaul opening is formed in the overhaul cover, a screw hole is formed in the overhaul opening, a fixing bolt is arranged on the screw hole, and the overhaul cover is fixed to the overhaul opening through the fixing bolt.

Further, the feed inlet is used for feeding the treated resin, the hydrolysate injection inlet is used for injecting hydrolysate, and the water outlet is used for discharging all liquid except the eluent.

Furthermore, the elution liquid pipe is used for sending the elution liquid into the lower device, the filter screen is used for filtering the elution liquid, the upper stirring shaft is used for stirring the resin and accelerating the reaction of other liquid, the upper sight glass is used for observing the inside of the upper device to facilitate work, and the upper thermometer is used for obtaining the inside temperature of the upper device to facilitate work.

Further, the alcohol injection opening is used for injecting 95 percent alcohol, the alcohol extraction opening is used for extracting the alcohol, and the lower sight glass is used for conveniently observing the precipitation condition.

The utility model discloses following beneficial effect has:

1. the utility model discloses a part about setting up, going on ion exchange, washing and elution setting at the upper portion device, will deposiing to set up and go on in the lower part device, and the upper portion device also can carry out work simultaneously when making it can carry out the longer sediment of time to the effectual work efficiency who increases ion exchange device.

2. The utility model discloses a set up the access hole, can maintain and clear up ion exchanger through the access hole, it sets up at the back of the upper and lower device of ion exchanger and carries out fixed seal with a plurality of fixing bolt to also can be convenient when having guaranteed the leakproofness maintain and clear up the inside of ion exchanger.

Of course, it is not necessary for any particular product to achieve all of the above-described advantages at the same time.

Drawings

In order to more clearly illustrate the technical solutions of the embodiments of the present invention, the drawings used in the description of the embodiments will be briefly introduced below, and it is obvious that the drawings in the following description are only some embodiments of the present invention, and it is obvious for those skilled in the art that other drawings can be obtained according to these drawings without creative efforts.

Fig. 1 is a schematic view of the overall structure of the present invention;

fig. 2 is a top view of the present invention;

FIG. 3 is an internal structural view of the present invention;

fig. 4 is a back view of the present invention;

fig. 5 is a structure view of the maintenance opening of the present invention.

In the drawings, the components represented by the respective reference numerals are listed below:

1. an upper device; 2. a lower device; 3. overhauling the device; 101. a feeding port; 102. a hydrolysate injection port; 103. a clean water injection port; 104. a dilute brine injection port; 105. concentrated brine injection ports, 106 and water discharge ports; 107. an eluent tube; 108. a filter screen; 109. an upper motor; 110. an upper stirring shaft; 111. an upper sight glass; 112. an upper thermometer; 201. an alcohol injection port; 202. extracting alcohol from the mouth; 203. a lower motor; 204. a lower stirring shaft; 205. a lower sight glass; 206. a lower thermometer; 301. an access cover; 302. fixing the bolt; 303. a screw hole; 304. and (6) an access hole.

Detailed Description

The technical solutions in the embodiments of the present invention will be described clearly and completely with reference to the accompanying drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only some embodiments of the present invention, not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by a person of ordinary skill in the art without creative efforts belong to the protection scope of the present invention.

Please refer to fig. 1-5, the utility model relates to an environment-friendly ion exchange device for producing crude heparin sodium, including upper portion device 1, lower part device 2 and maintenance device 3, upper portion device 1 mainly carries out ion exchange, washing and elution, and lower part device 2 mainly deposits, overhauls device 3 and sets up at the back of upper portion device 1 and lower part device 2, and the main effect of overhauing device 3 is overhauld and is cleaned ion exchange device.

The upper device 1 is provided with a material inlet 101, one side of the material inlet 101 is provided with a hydrolysate injection port 102, the other side of the material inlet 101 is provided with a dilute brine injection port 104, one side of the upper device 1 is provided with a clear water injection port 103, and the other side of the upper device 1 is provided with a concentrated brine injection port 105 and a water outlet 106 is arranged below the concentrated brine injection port 105.

The upper device 1 comprises an elution liquid pipe 107, a filter screen 108 is arranged at the bottom of the elution liquid pipe 107, an upper motor 109 is arranged on the side surface of the upper device 1, the upper motor 109 is connected with an upper stirring shaft 110, the upper stirring shaft 110 is arranged in the upper device 1, an upper sight glass 111 is arranged on the surface of the upper device 1, and an upper thermometer 112 is arranged on the side edge of the upper sight glass 111.

The lower device 2 comprises an alcohol injection port 201, an alcohol extraction port 202 is arranged below the alcohol injection port 201, a lower motor 203 is arranged on the side surface of the lower device 2, a lower stirring shaft 204 is connected with the lower motor 203, the lower stirring shaft 204 is arranged in the lower device 2, a lower sight glass 205 is arranged on the surface of the lower device 2, and a lower thermometer 206 is arranged on the side edge of the lower sight glass 205.

The maintenance device 3 comprises an access cover 301, an access opening 304 is formed in the access cover 301, a screw hole 303 is formed in the access opening 304, a fixing bolt 302 is arranged on the screw hole 303, and the access cover 301 is fixed on the access opening 304 through the fixing bolt 302.

The inlet 101 is used for introducing the treated resin, the hydrolysate inlet 102 is used for injecting the hydrolysate, and the outlet 106 is used for discharging all liquid except the eluent.

The eluent tube 107 is used for sending eluent into the lower device 2, the filter screen 108 is used for filtering eluent, the upper stirring shaft 110 is used for stirring resin and accelerating reaction of other liquid, the upper sight glass 111 is used for observing the inside of the upper device 1 to facilitate work, and the upper thermometer 112 is used for obtaining the inside temperature of the upper device 1 to facilitate work.

The alcohol injection port 201 is used for injecting 95 percent alcohol, the alcohol extraction port 202 is used for extracting the alcohol, and the lower sight glass 205 is used for observing the precipitation condition so as to facilitate work.

One specific application of this embodiment is: injecting hydrolysate through a hydrolysate injection port 102, controlling the temperature of the hydrolysate at 55 ℃, putting a treated 2.5 kg weight resin into an upper device (1) through a material inlet 101, then stirring and adsorbing for six hours, discharging waste liquid through a water outlet 106 after stirring, injecting clear water through a clear water injection port 103 until the resin is washed to be neutral, injecting 7 percent dilute saline with the weight 1.2 times that of the resin through a dilute saline injection port 104, stirring and washing twice, injecting 17 percent to 18 percent of concentrated saline into a concentrated saline injection port 105 through a concentrated saline injection port 105, carrying out elution twice, controlling the elution temperature between 20 and 25 ℃ for the first time and 2 hours for the second time, conveying the eluent into the lower device 1 through an eluent pipe 107, arranging a filter screen 108 at the bottom of the eluent pipe 107, adding 95 percent of alcohol equivalent to the volume of the eluent into the filtered eluent, stirring for a while, precipitating for 24 hours, extracting alcohol, and collecting heparin sodium at the bottom.

In the description herein, references to the description of "one embodiment," "an example," "a specific example," etc., mean that a particular feature, structure, material, or characteristic described in connection with the embodiment or example is included in at least one embodiment or example of the invention. In this specification, the schematic representations of the terms used above do not necessarily refer to the same embodiment or example. Furthermore, the particular features, structures, materials, or characteristics described may be combined in any suitable manner in any one or more embodiments or examples.

The preferred embodiments of the present invention disclosed above are intended only to help illustrate the present invention. The preferred embodiments are not intended to be exhaustive or to limit the invention to the precise embodiments disclosed. Obviously, many modifications and variations are possible in light of the above teaching. The embodiments were chosen and described in order to best explain the principles of the invention and its practical applications, to thereby enable others skilled in the art to best understand the invention for and utilize the invention. The present invention is limited only by the claims and their full scope and equivalents.

Claims

1. The utility model provides a production crude heparin sodium environment-friendly ion exchange device, includes upper portion device (1), lower part device (2) and overhauls device (3), its characterized in that: the ion exchange device comprises an upper device (1) and a lower device (2), wherein the upper device (1) mainly performs ion exchange, washing and elution, the lower device (2) mainly performs precipitation, a maintenance device (3) is arranged on the back surfaces of the upper device (1) and the lower device (2), the maintenance device (3) mainly performs maintenance and cleaning on the ion exchange device, the upper device (1) comprises an elution liquid pipe (107), a filter screen (108) is arranged at the bottom of the elution liquid pipe (107), an upper motor (109) is arranged on the side surface of the upper device (1), the upper motor (109) is connected with an upper stirring shaft (110), the upper stirring shaft (110) is arranged in the upper device (1), an upper sight glass (111) is arranged on the surface of the upper device (1), and an upper thermometer (112) is arranged on the side edge of the upper sight glass (111).

2. The environment-friendly ion exchange device for producing crude heparin sodium according to claim 1, wherein a feed inlet (101) is formed in the upper device (1), a hydrolysate injection port (102) is formed in one side of the feed inlet (101), a dilute brine injection port (104) is formed in the other side of the feed inlet (101), a clear water injection port (103) is formed in one side of the upper device (1), a concentrated brine injection port (105) is formed in the other side of the upper device (1), and a drain port (106) is formed below the concentrated brine injection port (105).

3. The environment-friendly ion exchange device for producing crude heparin sodium according to claim 1, wherein the lower device (2) comprises an alcohol injection port (201), an alcohol extraction port (202) is arranged below the alcohol injection port (201), a lower motor (203) is arranged on the side surface of the lower device (2), the lower motor (203) is connected with a lower stirring shaft (204), the lower stirring shaft (204) is arranged in the lower device (2), a lower sight glass (205) is arranged on the surface of the lower device (2), and a lower thermometer (206) is arranged on the side edge of the lower sight glass (205).

4. The environment-friendly ion exchange device for producing crude heparin sodium according to claim 1, wherein the maintenance device (3) comprises a maintenance cover (301), a maintenance opening (304) is formed in the maintenance cover (301), a screw hole (303) is formed in the maintenance opening (304), a fixing bolt (302) is arranged on the screw hole (303), and the maintenance cover (301) is fixed on the maintenance opening (304) through the fixing bolt (302).