CN214809882U

CN214809882U - Membrane system for standard fetal bovine serum deep ultrafiltration sterilization

Info

Publication number: CN214809882U
Application number: CN202120549853.6U
Authority: CN
Inventors: 何秀琴
Original assignee: Nanjing Hemiao Biotechnology Co ltd
Current assignee: Nanjing Hemiao Biotechnology Co ltd
Priority date: 2021-03-17
Filing date: 2021-03-17
Publication date: 2021-11-23
Anticipated expiration: 2031-03-17

Abstract

The utility model discloses a membrane-shaped system of sterilization of deep ultrafiltration of standard fetal calf serum relates to fetal calf serum technical field, for the pressurization mode of solving the membrane-shaped system of sterilization of the deep ultrafiltration of ordinary fetal calf serum among the prior art, harms the problem of serum easily. Sealed lid is installed to the top of filter, and sealed lid passes through bolt fixed connection with the filter, the inside of filter is provided with the increased pressure board, and increased pressure board and filter sliding connection, the cavity threaded rod is installed to the top of increased pressure board, and cavity threaded rod and increased pressure board fixed connection, the bracket is installed to the top of sealed lid, and bracket and sealed fixed connection that covers, the swivel mount is installed to the top of bracket, and swivel mount and bracket rotate to be connected, swivel mount and cavity threaded rod threaded connection, the feed liquor pipe is installed to one side of transfer pump, the transfer line is installed to the opposite side of transfer pump, feed liquor pipe and transfer line all pass through flange and transfer pump fixed connection.

Description

Membrane system for standard fetal bovine serum deep ultrafiltration sterilization

Technical Field

The utility model relates to a fetal calf serum technical field specifically is a membrane system of deep ultrafiltration sterilization of standard fetal calf serum.

Background

The fetal calf serum is a slightly viscous liquid with characteristics, light yellow and clear appearance, no hemolysis and no foreign matters, the fetal calf serum is taken from a fetal calf born by caesarean section, the new bovine serum is taken from a newborn calf within 24 hours of birth, and the calf serum is taken from a calf born for 10-30 days.

At present, in the domestic bovine serum production process, a filtering method is adopted, only a sterilization effect can be achieved simply, the requirement on cell culture is far from insufficient, most of domestic cells pollute mycoplasma and the like, the endotoxin content of the products exceeds the standard, and the batch uniformity of serum is unstable, so most of manufacturers and scientific research institutes of biological products select imported serum products, but when deep ultrafiltration sterilization is carried out on fetal bovine serum, the serum needs to be pressurized, generally a liquid pump is directly used for pressurizing, the pressure when the serum is pressurized is too concentrated, the serum is easily damaged, and the filtering quality of the fetal bovine serum is influenced; therefore, the market urgently needs to develop a standard fetal calf serum deep ultrafiltration sterilization membranous system to help people to solve the existing problems.

SUMMERY OF THE UTILITY MODEL

An object of the utility model is to provide a membrane system of sterilization is crossed in deep ultrafiltration of standard fetal calf serum to solve the pressurization mode of the membrane system of sterilization is crossed in the deep ultrafiltration of ordinary fetal calf serum that proposes in the above-mentioned background art, harm the problem of serum easily.

In order to achieve the above object, the utility model provides a following technical scheme: the utility model provides a deep ultrafiltration sterilization membranous system of standard fetal calf serum, includes filter and transfer pump, sealed lid is installed to the top of filter, and sealed lid and filter pass through bolt fixed connection, the inside of filter is provided with the increased pressure board, and increased pressure board and filter sliding connection, hollow threaded rod is installed to the top of increased pressure board, and hollow threaded rod and increased pressure board fixed connection, the bracket is installed to the top of sealed lid, and bracket and sealed lid fixed connection, the swivel mount is installed to the top of bracket, and swivel mount and bracket rotation are connected, swivel mount and hollow threaded rod threaded connection.

Preferably, the feed liquor pipe is installed to one side of transfer pump, the transfer line is installed to the opposite side of transfer pump, feed liquor pipe and transfer line all pass through flange and transfer pump fixed connection, the one end that the transfer pump was kept away from to the transfer line is installed the check valve, and check valve and transfer line fixed connection.

Preferably, the fluid-discharge tube is installed to the below of filter, and fluid-discharge tube and filter fixed connection, the internally mounted of filter has ultrafiltration sterilization membrane, and ultrafiltration sterilization membrane and filter fixed connection, the handle is installed to the top of sealed lid, and handle and sealed lid fixed connection.

Preferably, the fixing base is installed to the top of sealed lid, and fixing base and sealed lid fixed connection, driven gear is installed in the outside of transposition, and driven gear and transposition fixed connection, the motor is installed to the top of fixing base, and motor and fixing base fixed connection.

Preferably, the reduction gear is installed to the below of motor, drive gear is installed to the below of reduction gear, drive gear and motor all pass through shaft coupling and reduction gear fixed connection, drive gear is connected with the driven gear interlock.

Preferably, the air pump is installed to the top of sealed lid, and air pump and sealed lid fixed connection, install the gas-supply pipe on the preceding terminal surface of air pump, and the gas-supply pipe passes through flange fixed connection with the air pump, air cleaner is installed to the one end of gas-supply pipe, and air cleaner and gas-supply pipe fixed connection, air hose is installed to air cleaner's top, hollow threaded rod and air cleaner all with gas hose fixed connection.

Compared with the prior art, the beneficial effects of the utility model are that:

1. the utility model discloses a through the setting of increased pressure board, the increased pressure board setting is in the inside of filter, and accessible cavity screw rod orders about the increased pressure board and sinks, exerts pressure to serum through the increased pressure board, makes serum atress even when being pressurized through mechanical pressurization's mode, avoids serum to damage when being pressurized to improve the filtration quality of this filter, avoid fetal bovine serum to receive the damage.

2. The utility model discloses a through the setting of air pump, be the inside pressurization of filter through the air pump, in fetal bovine serum's filtration process, play supplementary pressurization volume effect to improve the speed that serum flows between ultrafiltration sterilization membrane, improve fetal bovine serum's filtration efficiency, make this filter work more high-efficient, the working effect is better.

Drawings

FIG. 1 is a front view of a membrane system for deep ultrafiltration sterilization of standard fetal bovine serum of the present invention;

FIG. 2 is a cross-sectional view of a membrane system for deep ultrafiltration sterilization of a standard fetal bovine serum of the present invention;

fig. 3 is an enlarged schematic view of a position a in the drawing of the present invention.

In the figure: 1. a filter; 2. a sealing cover; 3. an infusion pump; 4. a liquid inlet pipe; 5. a transfusion tube; 6. a liquid discharge pipe; 7. a handle; 8. a one-way valve; 9. a bracket; 10. rotating; 11. a driven gear; 12. a drive gear; 13. a hollow threaded rod; 14. a pressurizing plate; 15. a fixed seat; 16. a motor; 17. a speed reducer; 18. an air pump; 19. a gas delivery pipe; 20. an air filter; 21. a gas hose; 22. and (3) an ultrafiltration sterilization membrane.

Detailed Description

The technical solutions in the embodiments of the present invention will be described clearly and completely with reference to the accompanying drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only some embodiments of the present invention, not all embodiments.

Referring to fig. 1-3, the present invention provides an embodiment: the utility model provides a deep ultrafiltration sterilization membranous system of standard fetal calf serum, including filter 1 and transfer pump 3, sealed lid 2 is installed to filter 1's top, sealed lid 2 passes through bolt fixed connection with filter 1, filter 1's inside is provided with increased pressure board 14, increased pressure board 14 and filter 1 sliding connection, hollow threaded rod 13 is installed to increased pressure board 14's top, hollow threaded rod 13 and increased pressure board 14 fixed connection, bracket 9 is installed to sealed lid 2's top, bracket 9 and sealed 2 fixed connection of covering, swivel mount 10 is installed to bracket 9's top, swivel mount 10 rotates with bracket 9 to be connected, swivel mount 10 and hollow threaded rod 13 threaded connection.

Further, feed liquor pipe 4 is installed to one side of transfer pump 3, and transfer line 5 is installed to the opposite side of transfer pump 3, and feed liquor pipe 4 and transfer line 5 all pass through flange and transfer pump 3 fixed connection, and one-way valve 8 is installed to the one end that transfer line 5 kept away from transfer pump 3, and one-way valve 8 and transfer line 5 fixed connection, the inside of pressure plate 14 is provided with the check valve equally.

Further, fluid-discharge tube 6 is installed to filter 1's below, and fluid-discharge tube 6 and filter 1 fixed connection, the internally mounted of filter 1 has ultrafiltration sterilization membrane 22, ultrafiltration sterilization membrane 22 and filter 1 fixed connection, and handle 7 is installed to the top of sealed lid 2, handle 7 and sealed 2 fixed connection of lid, and ultrafiltration sterilization membrane 22 is provided with a plurality of, and handle 7 is provided with two.

Further, fixing base 15 is installed to the top of sealed lid 2, fixing base 15 and sealed 2 fixed connection of lid, and driven gear 11 is installed in swivel mount 10's the outside, driven gear 11 and swivel mount 10 fixed connection, and motor 16 is installed to the top of fixing base 15, and motor 16 and fixing base 15 fixed connection, sealed lid 2 can be dismantled.

Further, a speed reducer 17 is installed below the motor 16, a driving gear 12 is installed below the speed reducer 17, the driving gear 12 and the motor 16 are both fixedly connected with the speed reducer 17 through a coupler, the driving gear 12 is in meshed connection with the driven gear 11, and the motor 16 is a servo motor.

Further, an air pump 18 is installed above the sealing cover 2, the air pump 18 is fixedly connected with the sealing cover 2, an air pipe 19 is installed on the front end face of the air pump 18, the air pipe 19 is fixedly connected with the air pump 18 through a flange, an air filter 20 is installed at one end of the air pipe 19, the air filter 20 is fixedly connected with the air pipe 19, an air hose 21 is installed above the air filter 20, the hollow threaded rod 13 and the air filter 20 are both fixedly connected with the air hose 21, and the hollow threaded rod 13 is communicated with the pressurizing plate 14.

The working principle is as follows: when in use, the storage tank of fetal calf serum is connected through the liquid inlet pipe 4, the infusion pump 3 is started, the fetal calf serum is conveyed into the infusion pipe 5 through the infusion pump 3 and conveyed into the filter 1, the serum is conveyed to the position above the ultrafiltration sterilization membrane 22 at the highest position, on one hand, the serum flows downwards under the action of gravity, on the other hand, the motor 16 is started, the motor 16 decelerates through the reducer 17 and drives the driving gear 12, the driving gear 12 drives the rotary seat 10 to rotate through the driven gear 11, the hollow threaded rod 13 descends through the rotation of the rotary seat 10, the hollow threaded rod 13 pushes the pressurizing plate 14 to descend, so that the serum can be pressurized through the pressurizing plate 14, thereby the ultrafiltration sterilization work of the serum is realized, on the other hand, the air pump 18 is started, the air pump 18 conveys high-pressure air into the air conveying pipe 19, the air enters the air conveying hose 21 after being filtered through the air filter 20, and finally, the inside of the hollow threaded rod 13 is filled into the filter 1, so that the inside of the filter 1 is pressurized, and the filtering efficiency of fetal calf serum is improved.

It is obvious to a person skilled in the art that the invention is not restricted to details of the above-described exemplary embodiments, but that it can be implemented in other specific forms without departing from the spirit or essential characteristics of the invention. The present embodiments are therefore to be considered in all respects as illustrative and not restrictive, the scope of the invention being indicated by the appended claims rather than by the foregoing description, and all changes which come within the meaning and range of equivalency of the claims are therefore intended to be embraced therein. Any reference sign in a claim should not be construed as limiting the claim concerned.

Claims

1. The utility model provides a membrane system of sterilization of deep ultrafiltration of standard fetal calf serum, includes filter (1) and transfer pump (3), its characterized in that: sealed lid (2) is installed to the top of filter (1), and sealed lid (2) passes through bolt fixed connection with filter (1), the inside of filter (1) is provided with increased pressure board (14), and increased pressure board (14) and filter (1) sliding connection, cavity threaded rod (13) are installed to the top of increased pressure board (14), and cavity threaded rod (13) and increased pressure board (14) fixed connection, bracket (9) are installed to the top of sealed lid (2), and bracket (9) and sealed lid (2) fixed connection, swivel mount (10) are installed to the top of bracket (9), and swivel mount (10) rotate with bracket (9) and are connected, swivel mount (10) and cavity threaded rod (13) threaded connection.

2. The membrane system of claim 1, wherein the membrane system comprises: feed liquor pipe (4) is installed to one side of transfer pump (3), transfer line (5) are installed to the opposite side of transfer pump (3), feed liquor pipe (4) and transfer line (5) all through flange and transfer pump (3) fixed connection, one end that transfer pump (3) were kept away from in transfer line (5) is installed check valve (8), and check valve (8) and transfer line (5) fixed connection.

3. The membrane system of claim 1, wherein the membrane system comprises: fluid-discharge tube (6) are installed to the below of filter (1), and fluid-discharge tube (6) and filter (1) fixed connection, the internally mounted of filter (1) has ultrafiltration sterilization membrane (22), and ultrafiltration sterilization membrane (22) and filter (1) fixed connection, handle (7) are installed to the top of sealed lid (2), and handle (7) and sealed lid (2) fixed connection.

4. The membrane system of claim 1, wherein the membrane system comprises: fixing base (15) are installed to the top of sealed lid (2), and fixing base (15) and sealed lid (2) fixed connection, driven gear (11) are installed in the outside of swivel mount (10), and driven gear (11) and swivel mount (10) fixed connection, motor (16) are installed to the top of fixing base (15), and motor (16) and fixing base (15) fixed connection.

5. The membrane system of claim 4, wherein the membrane system comprises: reduction gear (17) are installed to the below of motor (16), drive gear (12) are installed to the below of reduction gear (17), drive gear (12) and motor (16) all pass through shaft coupling and reduction gear (17) fixed connection, drive gear (12) are connected with driven gear (11) interlock.

6. The membrane system of claim 1, wherein the membrane system comprises: air pump (18) are installed to the top of sealed lid (2), and air pump (18) and sealed lid (2) fixed connection, install air supply pipe (19) on the preceding terminal surface of air pump (18), and air supply pipe (19) pass through flange fixed connection with air pump (18), air cleaner (20) are installed to the one end of air supply pipe (19), and air cleaner (20) and air supply pipe (19) fixed connection, air hose (21) are installed to the top of air cleaner (20), cavity threaded rod (13) and air cleaner (20) all with air hose (21) fixed connection.