CN214794816U

CN214794816U - Reagent strip preprocessing device and medical equipment

Info

Publication number: CN214794816U
Application number: CN202023157484.0U
Authority: CN
Inventors: 吴家辉; 黄公安; 徐吉; 李根乾
Original assignee: Xingtong Medical Technology Suzhou Co ltd
Current assignee: Xingtong Medical Technology Suzhou Co ltd
Priority date: 2020-12-24
Filing date: 2020-12-24
Publication date: 2021-11-19
Anticipated expiration: 2030-12-24

Abstract

The utility model discloses a reagent strip preprocessing device and medical equipment, wherein the reagent strip preprocessing device comprises a tray and at least one reagent strip limiting groove; a tray fixing jig having a structure for fixing the tray thereon; the membrane opening device comprises a row of membrane opening cones arranged along the extending direction of the reagent strip limiting groove, wherein the membrane opening cones are vertically arranged, and a row of membrane opening cones are connected with a membrane opening driving device for driving the membrane opening cones to synchronously and vertically move and a horizontal driving device for driving the membrane opening driving device to horizontally move. According to the scheme, the reagent strips are installed through the tray, the tray position is fixed through the tray fixing jig, so that the membrane can be accurately torn through the membrane opening devices with the membrane opening cones for one time by puncturing membranes on all holes of the reagent strips, basic conditions are created for subsequent addition of test liquid, and technical support is provided for automatic realization.

Description

Reagent strip preprocessing device and medical equipment

Technical Field

The utility model belongs to the technical field of automatic medical equipment and specifically relates to reagent strip preprocessing device and medical equipment.

Background

The circularly enhanced fluoroimmunoassay is a highly sensitive fluoroimmunoassay which enhances the intensity of a fluorescent signal by a certain method, thereby enabling the detection of a target at a low concentration.

It is a great trend to realize the reaction and the corresponding detection by the automatic equipment, and in the automatic detection, the reagent strip needs to be preprocessed so as to facilitate the reaction and the test of the subsequent addition of the test solution for supply.

The reagent strip is provided with a fixing jig

(1) Reading the wells, reading the fluorescent signal on the probe in the wells;

(2) cleaning the hole, namely cleaning the interfering substance, the redundant signal antibody and the redundant fluorescent signal in the sample on the probe in the hole;

(3) a dry reagent well, in which a dry state reagent for sample treatment, signal antibody and fluorescence signal is disposed, and reacts with the probe after dissolution;

(4) the probe storage hole stores the probe therein and is locked by a protective cover.

The above (1) to (3) are covered with the protective film before the test, so that the protective film must be torn or broken for the subsequent operation;

meanwhile, the probe in the above (4) also needs to open the upper cover first and then move the probe during testing.

Therefore, an automated device that automatically implements the above functions is necessary.

SUMMERY OF THE UTILITY MODEL

The utility model aims at solving the problems in the prior art and providing a reagent strip preprocessing device and medical equipment.

The purpose of the utility model is realized through the following technical scheme:

the reagent strip pretreatment device comprises

The tray is provided with at least one reagent strip limiting groove;

a tray fixing jig having a structure for fixing the tray thereon;

the membrane opening device comprises a row of membrane opening cones arranged along the extending direction of the reagent strip limiting groove, wherein the membrane opening cones are vertically arranged, and a row of membrane opening cones are connected with a membrane opening driving device for driving the membrane opening cones to synchronously and vertically move and a horizontal driving device for driving the membrane opening driving device to horizontally move.

Preferably, in the reagent strip preprocessing device, the probe protective cover opening mechanism is arranged above the tray fixing jig and comprises a first opening cover plate capable of being lifted, the first opening cover plate is vertical and perpendicular to the reagent strip limiting groove, and the first opening cover plate is connected with a fourth driving mechanism for driving the first opening cover plate to lift.

Preferably, in the reagent strip preprocessing device, the first uncovering plate comprises a group of equidistant uncovering push rods, and the uncovering push rods can correspond to the reagent strip limiting grooves in position one to one.

Preferably, in the reagent strip preprocessing device, the probe protective cover opening mechanism further comprises a second opening cover plate parallel to the first opening cover plate and located at the inner side of the first opening cover plate in a clearance manner, and the lower end of the second opening cover plate extends to the lower side of the first opening cover plate.

Preferably, in the reagent strip pretreatment device, a pressure lever is arranged beside the membrane opening cone, the extending direction of the pressure lever is perpendicular to the extending direction of the reagent strip limiting groove, and the pressure lever can independently lift and can synchronously and horizontally move with the membrane opening cone.

Preferably, in the reagent strip preprocessing device, the number of the reagent strip limiting grooves is not less than 5, and the length of the pressing rod is not less than the sum of the widths of all the reagent strip limiting grooves.

Preferably, in the reagent strip pretreatment device, a clamping mechanism is further arranged above the fixed jig, and the clamping mechanism is connected with a mechanism for driving the clamping mechanism to lift and translate.

Preferably, in the reagent strip pretreatment device, the clamping mechanism is opened and closed by being driven by a motor.

Preferably, in the reagent strip pretreatment device, the tray is provided with a probe receiving hole.

Medical equipment, including any one above-mentioned reagent strip preprocessing device.

The utility model discloses technical scheme's advantage mainly embodies:

according to the scheme, the reagent strips are installed through the tray, the tray position is fixed through the tray fixing jig, so that the membrane can be accurately torn through the membrane opening devices with the membrane opening cones for one time by puncturing membranes on all holes of the reagent strips, basic conditions are created for subsequent addition of test liquid, and technical support is provided for automatic realization.

The automatic opening of probe visor can be realized effectively to the mechanism of uncapping of this scheme further sets up uncapping mechanism to the mechanism of uncapping of this scheme can be opened the probe visor of all reagent strips on the tray is whole through once-through operation, and it is efficient to uncap, and stability is good.

This scheme can be fixed the reagent strip when uncapping through the depression bar to avoid uncapping the action and cause not hard up, the displacement of reagent strip, be favorable to guaranteeing the stability of follow-up operation.

The clamping mechanism with the flexibly adjustable opening and closing size is further integrated, so that the probe can be conveniently moved out of the probe accommodating hole in the tray after the cover is opened, and convenience is brought to subsequent tests.

Drawings

Fig. 1 is a top view of the present invention;

fig. 2 is a partial end view of the present invention;

fig. 3 is a perspective view of the tray of the present invention;

FIG. 4 is a top view of the present invention with the cover opening mechanism and the clamping mechanism;

fig. 5 is a perspective view of a first viewing angle of the cover opening mechanism and the holding mechanism of the present invention;

fig. 6 is a cross-sectional view of the clamping mechanism of the present invention;

fig. 7 is a perspective view of a second viewing angle of the cover opening mechanism and the clamping mechanism of the present invention;

fig. 8 is a perspective view of the horizontal movement mechanism of the present invention.

Detailed Description

Objects, advantages and features of the present invention will be illustrated and explained by the following non-limiting description of preferred embodiments. These embodiments are merely exemplary embodiments for applying the technical solutions of the present invention, and all technical solutions formed by adopting equivalent substitutions or equivalent transformations fall within the scope of the present invention.

In the description of the embodiments, it should be noted that the terms "center", "upper", "lower", "left", "right", "front", "rear", "vertical", "horizontal", "inner", "outer", and the like indicate orientations or positional relationships based on the orientations or positional relationships shown in the drawings, and are only for convenience of description and simplicity of description, but do not indicate or imply that the devices or elements referred to must have a specific orientation, be constructed in a specific orientation, and be operated, and thus, should not be construed as limiting the present invention. Furthermore, the terms "first," "second," and "third" are used for descriptive purposes only and are not to be construed as indicating or implying relative importance. In the description of the embodiment, the operator is used as a reference, and the direction close to the operator is a proximal end, and the direction away from the operator is a distal end.

The reagent strip preprocessing device disclosed in the present invention is described below with reference to the accompanying drawings, as shown in fig. 1-2, it includes a tray 200, a tray fixing tool 300, and a film opening device 400.

As shown in fig. 1 and 3, the tray 200 includes at least one reagent strip limiting groove 210; specifically, the tray 200 includes a main body 220, the main body 220 is formed with 10 parallel reagent strip limiting grooves 210, each reagent strip limiting groove 210 includes two parallel and spaced vertically-arranged limiting surfaces 211, a bottom surface 212 is arranged between the two limiting surfaces 211 and is located at the lower end of the two limiting surfaces, a distal limiting rod 213 is arranged at an outer side of one end of each of the two limiting surfaces 211, a proximal limiting rod 214 is connected to the other end of each of the two limiting surfaces and is perpendicular to the one limiting surface, the top surface of the distal limiting rod 213 is higher than the bottom surface 212, and a gap 215 between the distal limiting rod 213 and the limiting surface 212 is used for removing reagent strips from the reagent strip limiting grooves 210 in the following process.

As shown in fig. 3, an end surface of the distal end limiting rod 213 facing the proximal end limiting rod 214 is an inclined surface, and a locking groove 216 is formed thereon, the locking groove 216 is used for limiting a reagent strip in the reagent strip limiting groove 210, the locking groove 216 is an arc-shaped through groove concavely formed in the side wall, and two ends of the arc-shaped through groove extend to the top surface and the bottom surface of the proximal end limiting rod 213.

As shown in FIG. 3, the width of the top edge of the arc-shaped through groove is smaller than that of the bottom edge, and the distance from the midpoint of the top edge of the arc-shaped through groove to the proximal limiting rod is smaller than that from the midpoint of the bottom edge of the arc-shaped through groove to the proximal limiting rod, so that the reagent strip can adapt to the change of the total length of the reagent strip and the control of the force required for pressing the reagent strip into the carrier is facilitated.

As shown in fig. 3, a probe receiving hole 230 matched with each reagent strip limiting groove is formed on the main body 220, and the probe receiving hole 230 is specifically disposed on the distal limiting rod 214, so as to be used for temporary storage of a probe on a reagent strip.

As shown in fig. 1 and 2, the tray 200 is fixed on the tray fixing jig 300, the tray fixing jig 300 includes a tray positioning plate 310, through holes 311 are disposed on the positioning plate 310 and located on two sides of the tray 200, an L-shaped fixing plate 320 is movably disposed in each through hole 311, the L-shaped fixing plate 320 can drive a fixing and releasing driving mechanism 330 that reciprocates in a direction perpendicular to the side edge of the tray 200, the two L-shaped fixing plates 320 can press two sides of the tray to fix the tray 200 on the positioning plate 310 after moving towards each other, and when the L-shaped fixing plates 320 move away from each other, the fixing of the tray 200 can be released. Further, the fixing and releasing mechanism 330 may also be connected to a lifting driving device (not shown in the drawings) for driving the lifting and lowering of the fixing and releasing mechanism.

After the reagent strips are loaded on the tray 200, the protective film covering each trough on the reagent strips needs to be removed or punctured to facilitate the subsequent operation, therefore, as shown in fig. 1 and fig. 2, the pretreatment device further comprises a membrane opening device 400 for puncturing the protective membrane of the reagent strip on the tray, the membrane opening device 400 comprises a row of membrane opening cones 410 arranged along the extending direction of the reagent strip limiting groove 210, the film opening cones 410 are vertically arranged, the number of the film opening cones 410 is consistent with the number of the material grooves on the reagent strip and corresponds to the material grooves on the reagent strip one by one, therefore, the film opening cones 410 can complete the film opening of all material grooves on one reagent strip at one time, one row of the film opening cones 410 are positioned below a vertical plate 440, and the vertical plate 440 is connected with a film opening driving device 420 for driving the film opening cones to vertically move and a horizontal driving device 430 for driving the film opening driving device 420 to horizontally move.

As shown in fig. 1, the film opening driving device 420 includes an air cylinder 421, an air cylinder shaft of the air cylinder 421 is vertically disposed and fixed on a sliding table 422 located outside the tray fixing jig 300, a body of the air cylinder 421 is slidably disposed on a first longitudinal guide rail 424 extending along a vertical direction (a direction perpendicular to both the first horizontal direction Y and the second horizontal direction X) through a first slider 423, the first longitudinal guide rail 424 is fixed on a side portion of the sliding table, a Z-shaped mounting rod 425 for mounting the film opening cone 410 is fixed on the first slider 423, and the mounting rod 425 extends out of a side of the sliding table close to the tray fixing jig 300.

As shown in fig. 1, the horizontal driving device 430 includes a motor 431, the motor 431 is connected to a horizontal screw 432 perpendicular to the reagent strip limiting groove and drives a screw of the horizontal screw 432 to rotate, an interactive nut of the horizontal screw 432 is connected to the sliding table 422, and the sliding table 422 is slidably disposed on two horizontal rails 423 parallel to the horizontal screw 432.

Further, as shown in fig. 1, a press rod 500 is disposed beside the row of the membrane opening cones 410, the extending direction of the press rod 500 is perpendicular to the extending direction of the reagent strip limiting grooves, the length of the press rod 500 is not less than the sum of the widths of all the reagent strip limiting grooves 210, the press rod 500 is connected with a press driving mechanism 600 for driving the press rod 500 to move vertically, the press driving mechanism 600 has the same structure as the membrane opening driving device 420, and comprises a lifting cylinder 610, the cylinder shaft of the lifting cylinder 610 is also fixed on the sliding table 422, the cylinder body of the lifting cylinder 610 is slidably disposed on a second longitudinal guide rail 630 extending in the perpendicular direction through a second slider 620, the second longitudinal guide rail 630 is fixed on the side of the sliding table 422, a Z-shaped mounting rod 640 for mounting the press rod 500 is fixed on the second slider 620, therefore, the plunger 500 is translated synchronously with the opening cone.

Further, as shown in fig. 4, a probe protective cover uncovering mechanism 80 is further arranged above the tray fixing jig 300, the probe protective cover uncovering mechanism 80 is used for opening a cover on the reagent strip, the probe protective cover uncovering mechanism 80 is arranged on the vertical frame 40, the probe protective cover uncovering mechanism 80 comprises a first uncovering plate 801, the first uncovering plate 801 is connected with a fourth driving mechanism 90 for driving the fourth uncovering plate to ascend and descend, and the fourth ascending and descending driving mechanism 90 is arranged on the vertical frame 40.

As shown in fig. 5, the lower portion of the first cover opening plate 801 includes a set of equidistant cover opening push rods 802, the number of the cover opening push rods 802 is preferably 10, and the cover opening push rods correspond to the reagent strip limiting grooves in a one-to-one manner, so that covers on a plurality of reagent strips can be opened simultaneously.

Meanwhile, a second opening cover plate 803 is arranged on the inner side of the first opening cover plate 801 in a clearance mode, the lower end of the second opening cover plate 803 extends to the lower portion of the first opening cover plate 801, the clearance between the second opening cover plate 803 and the first opening cover plate 801 is designed as required, when a protective cover for a reagent strip is opened, the clearance between the second opening cover plate 803 and the first opening cover plate 801 is met, and when the opening cover push rod 802 is embedded into a clamping groove at the end portion of the protective cover, the second opening cover plate 803 is in contact with the end portion of the protective cover.

As shown in fig. 5, the first open cover plate 801 and the second open cover plate 803 are both connected to the fourth driving mechanism 90, the fourth driving mechanism 90 includes a vertical connecting plate 901, the first open cover plate 801 and the second open cover plate 803 are disposed on both sides of the lower end of the vertical connecting plate 901, the upper end of the vertical connecting plate 901 is connected to an engaging block 902, the engaging block 902 is connected to a movable nut of a second lead screw 903 and slidably disposed on a second guide rail (not shown in the figure) extending in the vertical direction, and a screw of the second lead screw 903 is rotatably disposed on the upright 40 and connected to a motor 904 for driving the second lead screw to rotate.

As shown in fig. 5, the vertical frame 40 is further provided with a clamping mechanism 60, the clamping mechanism 60 and the mounting frame 8 are located at two opposite sides of the vertical frame 40, and the clamping mechanism 60 is connected with a third driving mechanism 70 for driving the clamping mechanism 60 to reciprocate along the vertical direction.

Specifically, as shown in fig. 6, the clamping mechanism 60 includes a second motor 601, a motor shaft of the second motor 601 extends in a longitudinal direction and is eccentrically connected to a transmission member 602, a rotation member 603 capable of rotating relative to the transmission member 602 is coaxially connected to the transmission member, the rotation member 603 may be a bearing, for example, the rotation member 603 is embedded in a mounting groove (not shown) of a first clamping block 604, the aperture of the mounting groove corresponds to the outer diameter of the rotation member 603, the first clamping block 604 is movably disposed on a guide rail 605 extending in the second horizontal direction X, the guide rail 605 is fixed on a fixed block 606, and the fixed block 606 is further provided with a second clamping block 607 cooperating with the first clamping block 604 for clamping.

When the clamping mechanism works, the second motor 601 drives the transmission piece 602 to rotate and drives the rotating piece 603 to rotate, and because the transmission piece 602 and the rotating piece 603 are eccentrically arranged, the rotating piece 603 revolves around the axis of the rotating piece 602, so that the first clamping block 604 is driven to reciprocate along the guide rail 605, and the distance between the first clamping block 604 and the second clamping block 607 is changed, so that the clamping mechanism is opened and closed.

As shown in fig. 7, the fixed block 606 is connected to a third driving mechanism 70 for driving the fixed block 606 to reciprocate in the vertical direction, specifically, the third driving mechanism 70 includes a carrier plate 701 for fixing the fixed block 606, the carrier plate 701 is connected to a movable nut of a lead screw 703 through a transfer block 702, a screw of the lead screw 703 extends in the vertical direction and both ends of the screw are rotatably disposed on the stand 40, the lead screw 703 is located at a side portion (left side) of the second lead screw 903, one end of the screw is connected to a motor 704 for driving the screw to rotate and is fixed on the stand 40, the motor 704 is slidably disposed on the stand 702, the transfer block 702 is further connected to a sliding block 705, the sliding block 705 is slidably disposed on a sliding rail 706 extending in the vertical direction, and the sliding rail 706 is disposed on the stand 40.

Of course, in other embodiments, the third driving mechanism 70 may be implemented by a rodless cylinder, a hydraulic cylinder, or an electric push rod.

In actual operation, it is necessary to horizontally move the stand 40 to meet the requirements for grasping and transferring at different positions, and therefore, as shown in fig. 4 and 5, the stand 40 is connected to a horizontal movement mechanism 100 for driving the stand to move in the first horizontal direction Y and the second horizontal direction X, and the horizontal movement mechanism 100 may have various known configurations. In a preferred embodiment, as shown in fig. 7, the first translational driving mechanism 110 and the second translational driving mechanism 120 are included, as shown in fig. 7 and 8, the first translational driving mechanism 110 includes a moving frame 116, one end of the moving frame 116 is provided with a first translational motor 111, a motor shaft of the first translational motor 111 is coaxially connected with a synchronous pulley 112, the synchronous pulley 112 is connected with a driven synchronous pulley 114 through a synchronous belt 113, the driven synchronous pulley 114 is rotatably arranged at the other end of the moving frame 116, a clamping block 115 is fixed on the synchronous belt 113, the clamping block 115 is fixed on the stand 40, and the stand 40 is slidably arranged on a horizontal rail extending in the first horizontal direction Y through a sliding block 117. As shown in fig. 5, the second translation driving mechanism 120 has a structure equivalent to that of the first translation driving mechanism 110, and the first translation driving mechanism 110 is translated by using mechanisms such as a motor 121, a synchronizing wheel 122, a synchronizing belt 123, a clamping block 124, and a guide rail 125, which are not described herein again.

The embodiment also discloses medical equipment comprising the reagent strip pretreatment device.

The utility model has a plurality of implementation modes, and all technical schemes formed by adopting equivalent transformation or equivalent transformation all fall within the protection scope of the utility model.

Claims

1. Reagent strip preprocessing device, its characterized in that: comprises that

The tray is provided with at least one reagent strip limiting groove;

a tray fixing jig having a structure for fixing the tray thereon;

2. The reagent strip pretreatment device of claim 1, wherein: the probe protective cover uncovering mechanism is arranged above the tray fixing jig and comprises a first uncovering plate capable of ascending and descending, the first uncovering plate is vertical and perpendicular to the reagent strip limiting groove, and the first uncovering plate is connected with a fourth driving mechanism for driving the first uncovering plate to ascend and descend.

3. The reagent strip pretreatment device of claim 2, wherein: the first uncovering plate comprises a group of equidistant uncovering push rods, and the uncovering push rods can correspond to the reagent strip limiting groove in position one to one.

4. The reagent strip pretreatment device of claim 2, wherein: the probe protective cover uncovering mechanism further comprises a second cover opening plate which is parallel to the first cover opening plate and is located on the inner side of the first cover opening plate in a gap mode, and the lower end of the second cover opening plate extends to the position below the first cover opening plate.

5. The reagent strip pretreatment device of any one of claims 1 to 4, wherein: a pressing rod is arranged beside the membrane opening cone, the extending direction of the pressing rod is perpendicular to the extending direction of the reagent strip limiting groove, and the pressing rod can independently lift and can synchronously and horizontally move with the membrane opening cone.

6. The reagent strip pretreatment device of claim 5, wherein: the number of the reagent strip limiting grooves is not less than 5, and the length of the pressing rod is not less than the sum of the widths of all the reagent strip limiting grooves.

7. The reagent strip pretreatment device of claim 5, wherein: and a clamping mechanism is further arranged above the tray fixing jig and connected with a mechanism for driving the tray fixing jig to ascend, descend and translate.

8. The reagent strip pretreatment device of claim 7, wherein: the clamping mechanism is driven by a motor to open and close.

9. The reagent strip pretreatment device of claim 7, wherein: the tray is provided with a probe accommodating hole.

10. Medical equipment, its characterized in that: comprising a reagent strip pretreatment device according to any one of claims 1 to 9.