Automatic biological sample coating device
Technical Field
The utility model belongs to the technical field of medical instrument, concretely relates to automatic coating device of biological sample.
Background
Traditional medical slide glass is paintd and is all that the work load that adopts artifical paining is big, it is strong to be the repeatability, the activity that intensity of labour is big, waste time and energy and efficiency are very low, and the proficiency of the operation of artifical paining is different, the effect of staff's paining is also different, and the factor that artifical paining influences the effect is too many (mood, uncomfortable etc.), final experimental observation effect that probably influences, along with automatic continuous development, the quality of artifical paining has not reached the precision that needs now far away, and the artifical expense of present stage also progressively risees, the maximize of pursuit benefit simultaneously, the enterprise needs automation equipment to accomplish above-mentioned action, provide power for social development.
Traditionally, application No. 201611113331.1 provides an automatic slide reagent smearing device, which consists of a horizontal support, a vertical support, a conveyor belt module, a smearing module, a reagent supply module, a fan, a slide conveying plate and a slide collection box. The method is characterized in that: the automatic reagent smearing device is characterized in that the vertical supports are of V-shaped plates and comprise four vertical supports located at four corners of the whole device, the horizontal supports are mounted at the lower portions of the vertical supports, the number of the horizontal supports is two, the conveyor belt modules are mounted below the vertical supports and above the horizontal supports, the smearing module is mounted on the vertical supports and above the conveyor belt modules, the reagent supply module is mounted above the vertical supports and above the smearing module, the fan is mounted on the smearing module, the slide glass conveying plate is mounted on the conveyor belt modules, and the slide glass collecting box is mounted on the horizontal supports. However, the device provided by the patent can only smear a uniform type of reagent on the slide glass, and cannot realize smearing on biological samples with individuality differentiation.
Therefore, there is a need for an automatic biological sample coating device capable of coating biological samples with different individual differences while ensuring high quality coating, so as to meet the needs of practical detection work.
SUMMERY OF THE UTILITY MODEL
In order to solve the problem, the utility model provides an automatic coating device of biological sample when guaranteeing that the high quality scribbles the appearance, can realize scribbling the appearance of biological sample of different individual differences to satisfy the needs in the actual detection work.
In order to achieve the above object, the present invention provides an automatic coating device for biological samples, comprising:
the coating device comprises a coating rod and a rotary coating driving part, wherein one end of the coating rod is in transmission connection with the rotary coating driving part, and a soft sample coating part is arranged at the other end of the coating rod;
the coating driving mechanism comprises a horizontal moving module and a vertical moving module, the vertical moving module is arranged at the movable end of the horizontal moving module, and the coating device is arranged at the movable end of the vertical moving module;
the coating driving mechanism can drive the sample coating device to move in the horizontal direction and the vertical direction, and the rotary sample coating driving part can drive the coating rod to rotate.
In a further improvement of the above aspect, the material of the soft coating portion is a soft material having water absorption property.
As a further improvement of the scheme, the soft sample coating part is arranged at the lower end of the coating rod, and an included angle formed between the soft sample coating part and the coating rod is 90-180 degrees.
As a further improvement of the above scheme, the horizontal moving module and the vertical moving module comprise but are not limited to a servo lead screw moving module.
As a further improvement of the scheme, the automatic biological sample coating device also comprises a cleaning unit used for cleaning the sampling rod, and the cleaning unit is arranged on the horizontal moving path of the coating device.
As a further improvement of the scheme, the cleaning unit comprises a cleaning support, a first cleaning pipe and a second cleaning pipe, the first cleaning pipe and the second cleaning pipe are sequentially connected from top to bottom and arranged on the cleaning support, a cleaning liquid filling port is formed in the first cleaning pipe and used for filling cleaning liquid, a waste liquid collecting port is formed in the second cleaning pipe and used for being connected with a waste liquid collecting container, and the two cleaning pipes from top to bottom are arranged to ensure the cleaning cleanliness of the sampling rod.
As a further improvement of the above scheme, the automatic biological sample coating device further comprises an automatic slide supply unit, which comprises a slide box and a slide pushing mechanism, wherein the slide box is erected on a pushing path of the slide pushing mechanism, the slide pushing mechanism can push away a slide at each time to keep away from the slide box, the pushing path of the slide pushing mechanism and a horizontal moving path of the coating device have a cross point, and the cross point is a biological sample coating station.
As a further improvement of the above scheme, slide push mechanism includes that base, propelling movement drive unit and propelling movement move the end, propelling movement drive unit sets up on the base, the propelling movement is moved the end and is connected with propelling movement drive unit transmission, and can horizontal migration under propelling movement drive unit's drive, the propelling movement is moved the end and can be moved the slide box under to can be with depositing in slide box below slide box propelling movement slide box one by one and remove the slide to the assigned position.
As a further improvement of the above scheme, the slide automatic supply unit further comprises a slide box support and a limiting device, the slide box is erected on the base through the slide box support, and the limiting device is arranged at the rear side of the slide box support and used for limiting the rear moving position of the pushing moving end so as to ensure that the lowest slide in the slide box falls on the pushing moving end and can be pushed.
As a further improvement of the above scheme, the limiting device comprises a limiting block, a limiting rod and a damping piece, the damping piece is arranged between the limiting block and the limiting rod, the limiting rod is connected with the rear wall of the glass box support, and the limiting block is used for abutting against the pushing moving end.
As a further improvement of the scheme, the limiting device further comprises a guide assembly, and the guide assembly is arranged below the limiting block.
As a further improvement of the above scheme, the guide assembly comprises a linear guide rail and a slider, the linear guide rail is arranged on the side wall of the slide box support, and the slider is arranged below the limiting block.
As a further improvement of the above, the damping member includes, but is not limited to, a spring.
As a further improvement of the above scheme, the slide cassette includes a slide cassette body and a slide cassette cover, one side of the slide cassette cover is hinged to one side of the slide cassette body, and the other side of the slide cassette cover is fastened to the other side of the slide cassette body.
As a further improvement of the above scheme, two sides of the bottom wall of the slide box body are respectively provided with a push-off opening for the push moving end to pass through.
As a further improvement of the above scheme, the pushing moving end comprises a pushing support and a U-shaped slide pushing plate arranged on the top surface of the pushing support, two supporting arms of the U-shaped slide pushing plate are symmetrically provided with grooves, the two grooves are used for accommodating slides, and the height of the rear wall of the U-shaped slide pushing plate is lower than the outer side surface of the bottom wall of the slide box body.
As a further improvement of the above solution, the pushing driving unit includes, but is not limited to, a servo lead screw driving module, a servo chain driving module, or a servo belt driving module, and the pushing moving end is disposed at a moving output end of the pushing driving unit.
Because the utility model adopts the above technical scheme, make the beneficial effect that this application possesses lie in:
1. the utility model discloses an automatic coating device of biological sample, include: the coating device comprises a coating rod and a rotary coating driving part, wherein one end of the coating rod is in transmission connection with the rotary coating driving part, and a soft sample coating part is arranged at the other end of the coating rod; the coating driving mechanism comprises a horizontal moving module and a vertical moving module, the vertical moving module is arranged at the movable end of the horizontal moving module, and the coating device is arranged at the movable end of the vertical moving module; the coating driving mechanism can drive the sample coating device to move in the horizontal direction and the vertical direction, and the rotary sample coating driving part can drive the coating rod to rotate; the sample coating device is driven by the coating driving mechanism to move in the horizontal direction, so that the sample coating device can move to different stations for operation, such as a sampling station, a cleaning station and a sample coating station; scribble appearance device and realize the removal of vertical direction under coating actuating mechanism's drive for the sampling rod can stretch into the test tube and take a sample, realizes taking a sample, scribbles a kind automation mechanized operation.
2. The utility model discloses an automatic coating device of biological sample still includes the cleaning unit for wash the sampling rod, just the cleaning unit sets up on the horizontal migration route of coating device, the setting of cleaning unit for the sampling rod can be timely obtain wash in order to be equipped with the sample of different biological sample, thereby realize the sample of the biological sample of different individual differences and scribble the appearance, with the needs that satisfy actual work.
3. The utility model discloses an automatic biological sample coating device, still include slide automatic supply unit, it includes slide box and slide push mechanism, slide box erects on slide push mechanism's propelling movement route, slide push mechanism can push away from a slide at every turn and keep away from slide box, and slide push mechanism's propelling movement route and coating device's horizontal migration route have the crosspoint, the crosspoint is the biological sample and scribbles the appearance station; slide push mechanism includes that base, propelling movement drive unit and propelling movement move the end, propelling movement drive unit sets up on the base, the propelling movement moves the end and is connected with the transmission of propelling movement drive unit, and can horizontal migration under propelling movement drive unit's drive, the propelling movement moves the end and can move under the slide box to can be with depositing slide box below slide box propelling movement slide box one by one and remove the slide to the assigned position. According to the arrangement, the slide box is only required to be erected on the base of the slide pushing mechanism, the pushing and moving end is driven by the pushing driving unit to move to the position under the slide box, the slides stored at the lowest part of the slide box can be pushed out of the slide box one by one and moved to the designated position, so that automatic supply of the slides is realized, the labor intensity of operators is reduced, and the labor efficiency is improved; and because the pushing and moving end can move the slide to the designated position, the slide feeding device has no strict requirement on the installation precision of the equipment, greatly reduces the matching difficulty of the slide feeding device and the related equipment, and also means reduces the linkage control difficulty of the slide feeding device and the related equipment.
4. The utility model discloses an automatic biological sample coating device, the propelling movement end comprises a propelling support and a U-shaped slide push plate arranged on the top surface of the propelling support, two support arms of the U-shaped slide push plate are symmetrically provided with grooves for accommodating slides, and the height of the rear wall of the U-shaped slide push plate is lower than the outer side surface of the bottom wall of a slide box body; the two sides of the bottom wall of the slide box body are respectively provided with a push-off opening for the two support arms of the push moving end to pass through, the arrangement is convenient for the push moving end to move right below the slide box, because the two sides of the bottom wall of the slide box body are respectively provided with the push-off openings, and the height of the rear wall of the U-shaped slide push plate is lower than the outer side surface of the bottom wall of the slide box body, the lowest slide in the slide box can fall into the symmetrically arranged grooves, and along with the movement of the pushing and moving end, the slide glass is pushed out of the slide box and is moved to a designated position, the slide glass pushing and separating mechanism of the utility model has simple structure, and the simple operation, and the slide box push away from under the cooperation of opening and U type slide push pedal, realize that the slide falls into the recess automatically under the effect of dead weight, for the traditional mode that utilizes the push pedal to push away from the slide rear side, the influence that greatly reduced push pedal self thickness and rigidity pushed away the degree of accuracy to the slide.
Drawings
In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings needed to be used in the description of the embodiments or the prior art will be briefly described below, it is obvious that the drawings in the following description are only some embodiments of the present invention, and for those skilled in the art, other drawings can be obtained according to the drawings without creative efforts;
fig. 1 is a schematic perspective view of an embodiment 1 of an automatic coating apparatus for biological samples according to the present invention;
fig. 2 is a schematic perspective view of an embodiment 2 of an automatic coating apparatus for biological samples according to the present invention;
FIG. 3 is a top view of an embodiment 2 of the automatic coating apparatus for biological samples according to the present invention;
fig. 4 is a schematic perspective view of an automatic slide supply unit according to embodiment 2 of the present invention;
fig. 5 is a partial perspective view of an automatic slide supply unit according to embodiment 2 of the present invention;
FIG. 6 is a schematic front view of an automatic slide supply unit according to embodiment 2 of the present invention;
FIG. 7 is a cross-sectional view B-B of FIG. 6;
the reference numbers are as follows:
1. a coating device; 11. coating a rod; 111. a soft coating portion; 12. a spin coating drive section;
2. a coating drive mechanism; 21. a horizontal moving module; 22. a vertical moving module;
3. a cleaning unit; 31. cleaning the bracket; 32. a first cleaning pipe; 33. a second cleaning pipe;
4. an automatic slide supply unit; 41. a cassette for glass sheets; 42. a slide pushing mechanism; 421. a push driving unit; 422. pushing the mobile terminal; 4221. pushing the support; 4222. a U-shaped slide push plate; 423. a cassette holder; 424. a limiting device; 5. a glass slide;
A. a push path; B. a horizontal movement path; a. a sampling station; b. cleaning a station; c. and a sample coating station.
Detailed Description
The technical solutions in the embodiments of the present invention will be described clearly and completely with reference to the accompanying drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only some embodiments of the present invention, not all embodiments. Based on the embodiments in the present invention, all other embodiments obtained by a person skilled in the art without creative efforts belong to the protection scope of the present invention.
It should be noted that all the directional indicators in the embodiments of the present invention, such as the first, second, upper, lower, left, right, front and rear … …, are only used to explain the relative position relationship between the components, the motion situation, etc. in a specific posture as shown in the drawings, and if the specific posture is changed, the directional indicator is changed accordingly.
In addition, the technical solutions between the embodiments of the present invention can be combined with each other, but it is necessary to be able to be realized by a person having ordinary skill in the art as a basis, and when the technical solutions are contradictory or cannot be realized, the combination of such technical solutions should be considered to be absent, and is not within the protection scope of the present invention.
The invention will be further described with reference to the following figures:
example 1:
referring to fig. 1, the present invention provides an automatic coating apparatus 1 for biological samples, comprising:
the coating device 1 comprises a coating rod 11 and a rotary coating driving part 12, wherein one end of the coating rod is in transmission connection with the rotary coating driving part, the other end of the coating rod is provided with a soft sample coating part 111, and the material of the soft sample coating part 111 has water absorption;
the coating driving mechanism 2 comprises a support frame (not shown in the figure), a horizontal moving module 21 and a vertical moving module 22, wherein the horizontal moving module 21 is arranged on the support frame, the vertical moving module 22 is arranged at the movable end of the horizontal moving module 21, and the coating device 1 is arranged at the movable end of the vertical moving module 22;
the coating driving mechanism 2 can drive the sample coating device to move in the horizontal direction and the vertical direction, the rotary sample coating driving part can drive the coating rod to rotate, and in the embodiment, the rotary sample coating driving part is a micro motor; with the arrangement, under the driving of the coating driving mechanism 2, the soft sample coating part 111 on the coating rod can be attached to the glass slide 5, and when the sample is coated in a rotating manner, the biological sample is uniformly coated on the glass slide 5 due to the extrusion between the soft sample coating part 111 and the glass slide 5; the sample coating device is driven by the coating driving mechanism 2 to move in the horizontal direction, so that the sample coating device can move to different stations for operation, such as a sampling station a, a cleaning station b and a sample coating station c; scribble the removal that appearance device realized vertical direction under the drive of coating actuating mechanism 2 for the sampling rod can stretch into the test tube and take a sample, realizes taking a sample, scribbles a kind automation mechanized operation.
In a preferred embodiment, the soft coating portion 111 is disposed at the lower end of the coating rod and forms an included angle of 90 to 180 degrees with the coating rod, and in this embodiment, the material of the soft coating portion 111 has water absorption, so that the soft coating portion 111 forms an included angle of 180 degrees with the lower end of the coating rod, and the soft coating portion 111 is pushed against the slide glass 5 to be bent under the driving of the vertical movement module 22, so as to adhere to the slide glass 5.
As a preferred embodiment, the horizontal moving module 21 and the vertical moving module 22 each include, but are not limited to, a servo lead screw moving module, and in this embodiment, the horizontal moving module 21 and the vertical moving module 22 are both servo lead screw moving modules.
As a preferred embodiment, the automatic biological sample coating device 1 further comprises a cleaning unit 3 for cleaning the sampling rod, and the cleaning unit 3 is disposed on the horizontal moving path B of the coating device 1, and the cleaning unit 3 is disposed so that the sampling rod can be cleaned in time for sampling different biological samples, thereby realizing sampling and coating of biological samples with different individual differences to meet the needs of actual work.
As a preferred embodiment, the cleaning unit 3 includes a cleaning support 31, a first cleaning pipe 32 and a second cleaning pipe 33, the first cleaning pipe 32 and the second cleaning pipe 33 are sequentially connected to the cleaning support 31 from top to bottom, a cleaning liquid filling port is arranged on the first cleaning pipe 32 for filling a cleaning liquid, a waste liquid collecting port is arranged on the second cleaning pipe 33 for connecting a waste liquid collecting container, and the arrangement of the two cleaning pipes from top to bottom enables the waste liquid to flow out of the first cleaning pipe 32 in time to ensure the cleaning degree of the sampling rod.
Example 2:
referring to fig. 2-7, the utility model also provides an automatic coating device 1 of biological sample still sets up slide automatic feeding unit 4 on the basis of above-mentioned structure, just slide automatic feeding unit 4 includes slide box 41 and slide push mechanism 42, slide box 41 erects on slide push mechanism 42's propelling movement route A, and slide push mechanism 42 can push away from a slide 5 at every turn and keep away from slide box 41, just slide push mechanism 42's propelling movement route A and coating device 1's horizontal migration route B have the intersect, the intersect scribbles appearance station c for the biological sample. With such an arrangement, the slide cassette 41 only needs to be mounted on the base of the slide 5 pushing mechanism 42, the pushing moving end 422 is driven by the pushing driving unit 421 to move to the position right below the slide cassette 41, and can push the slides 5 stored at the lowest position of the slide cassette 41 out of the slide cassette 41 one by one and move the slides 5 to the designated position, so that the automatic supply of the slides 5 is realized, the labor intensity of operators is reduced, and the labor efficiency is improved; and because the pushing and moving end 422 can move the slide 5 to the designated position, the installation accuracy of the equipment is not strictly required, the matching difficulty of the slide 5 supply device and the related equipment is greatly reduced, and the linkage control difficulty of the slide 5 supply device and the related equipment is also reduced.
As a preferred embodiment, the slide pushing mechanism 42 includes a base, a pushing driving unit 421 and a pushing moving end 422, the pushing driving unit 421 is disposed on the base, the pushing moving end 422 is in transmission connection with the pushing driving unit 421 and can horizontally move under the driving of the pushing driving unit 421, the pushing moving end 422 can move right below the slide cassette 41 and can push the slide 5 stored at the lowest position of the slide cassette 41 out of the slide cassette 41 one by one and move the slide 5 to a designated position.
As a preferred embodiment, referring to fig. 4, the slide automatic supply unit 4 further includes a cassette support 423 and a limiting device 424, the cassette 41 is mounted on the base through the cassette support 423, and the limiting device 424 is disposed at the rear side of the cassette support 423 for limiting the rear moving position of the pushing moving end 422, so as to ensure that the lowermost slide 5 in the cassette 41 falls onto the pushing moving end 422 and can be pushed.
As a preferred embodiment, referring to fig. 4, the limiting device 424 includes a limiting block, a limiting rod, a damping member and a guiding component, the damping member is disposed between the limiting block and the limiting rod, the limiting rod is connected with the rear wall of the slide cassette support 423 through a thread, and the limiting block is used for abutting against the pushing moving end 422 to limit the moving position thereof; the direction sets up in the below of stopper, and is concrete, the direction subassembly includes linear guide and slider, linear guide sets up on the lateral wall of slide box support 423, the slider sets up below the stopper, in this embodiment, stop device 424 is two, and two stop device 424 set up the inside both sides between slide box 41 respectively, the damping piece is the spring, and the spring housing is established on the gag lever post, and the one end and the stopper of spring are contradicted, and the other end of spring is contradicted with the back wall inboard between slide box 41.
As a preferred embodiment, referring to fig. 4 and 5, in order to facilitate the placement of the slide 5, the slide cassette 41 includes a slide cassette 41 body and a slide cassette 41 cover, one side of the slide cassette 41 cover is hinged to one side of the slide cassette 41 body, and the other side of the slide cassette 41 cover is fastened to the other side of the slide cassette 41 body, so that when the slide in the slide cassette 41 is used up, the slide can be loaded by only opening the slide cassette 41 cover, which is convenient and fast; in some embodiments, the cassette 41 can also be removably attached to the cassette 41, and when the slide in the cassette 41 is depleted, the entire cassette 41 can be removed and replaced with a new cassette 41 to be processed.
As a preferred embodiment, the pushing moving end 422 includes a pushing support 4221 and a U-shaped slide push plate 4222 arranged on the top surface of the pushing support 4221, two arms of the U-shaped slide push plate 4222 are symmetrically provided with grooves for accommodating the slide 5, and the height of the rear wall of the U-shaped slide push plate 4222 is lower than the outer side surface of the bottom wall of the slide box 41 body; two sides of the bottom wall of the slide box 41 body are respectively provided with a push-off opening for the two support arms of the push moving end 422 to pass through. Such setting makes things convenient for the propelling movement end 422 to move under slide box 41, because the both sides of the diapire of slide box 41 body are equipped with respectively and pushes away from the opening, and the diapire lateral surface that highly is less than slide box 41 body of U type slide push pedal 4222's back wall for slide 5 of the bottom in the slide box 41 can fall into the recess that the symmetry set up, and along with the propelling movement end 422's removal, slide 5 is pushed out slide box 41 and is moved the assigned position, the utility model discloses a slide pushes away from mechanism simple structure, and convenient operation, and slide box 41 pushes away under opening and U type slide push pedal 4222's the cooperation, realizes that the slide is automatic to fall into in the recess under the effect of dead weight, for the traditional mode that utilizes the push pedal to push away from the slide rear side, greatly reduced push pedal self thickness and rigidity to the slide influence of pushing away the degree of accuracy.
As a preferred embodiment, the pushing driving unit 421 includes, but is not limited to, a servo screw driving module, a servo chain driving module, or a servo belt driving module, and the pushing moving end 422 is disposed at a moving output end of the pushing driving unit 421.
The working procedure of example 2 is as follows:
the pushing moving end 422 of the slide automatic supply unit 4 pushes away one slide 5 from the slide cassette 41, and under the driving of the pushing driving unit 421, the taken slide 5 is conveyed to the sample coating station c; meanwhile, the sample coating device is driven by the horizontal moving module 21 to move to a sampling station a, a biological sample is absorbed from a test tube to be detected, after the sample is absorbed, the vertical moving module 22 is lifted upwards to separate from the test tube, then driven by the horizontal moving module 21 to a sample coating station c, the vertical moving module 22 is lowered downwards until the soft sample coating part 111 is abutted and attached to the glass slide 5, and the rotary sample coating driving part drives the coating rod to rotate to coat the sample and take away the glass slide 5 after the sample coating is completed by manual work or other butt joint equipment; scribble the appearance and accomplish the back, vertical removal module 22 upwards promotes and scribbles a kind device to move to cleaning unit 3 top under the drive of horizontal migration module 21, vertical removal module 22 descends downwards and washs in submerging first scavenge pipe 32 until the coating rod, circulates in proper order, and the test tube that reaches sample station a detects the completion.
The above is a detailed introduction of the present invention, and the principles and embodiments of the present invention have been explained herein using specific embodiments, and the explanations of the above embodiments are only used to help understand the methods and core ideas of the present invention. It should be noted that, for those skilled in the art, without departing from the principle of the present invention, the present invention can be further modified and modified, and such modifications and modifications also fall within the protection scope of the appended claims.