CN214621797U - Sampling device of rat brain tissue sample - Google Patents
Sampling device of rat brain tissue sample Download PDFInfo
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- CN214621797U CN214621797U CN202120553153.4U CN202120553153U CN214621797U CN 214621797 U CN214621797 U CN 214621797U CN 202120553153 U CN202120553153 U CN 202120553153U CN 214621797 U CN214621797 U CN 214621797U
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Abstract
The utility model belongs to the technical field of medical experiment equipment, a sampling device of rat brain tissue sample is provided, include base, first guide bar, first screw rod, first knob, second guide bar, second screw rod, second knob, first sliding frame, second sliding frame, place platform, sleeve, sampling tube, reset spring, die cavity mould head and positive negative pressure device. The utility model provides a sampling device of rat brain tissue sample, the location is accurate, the sample is rapid.
Description
Technical Field
The utility model relates to a medical science experimental device technical field, concretely relates to sampling device of rat brain tissue sample.
Background
In the animal experiment process, the brain tissue of the experimental animal is often required to be sampled and researched, and the commonly adopted brain slice sampling method at present is to suck by a common dropper or directly obtain by tweezers.
The method has the following disadvantages: according to the method, after an experimenter judges a sampling position by naked eyes, a dropper or a forceps is used for sampling, so that the brain slice sampling positioning performance is poor, the randomness is high, the brain tissue around the sampling is easily damaged, and the repeatability of the experiment is poor.
SUMMERY OF THE UTILITY MODEL
To the defect among the prior art, the utility model aims at providing a sampling device of rat brain tissue sample to solve the problem of proposing in the background art.
In order to achieve the above object, the present invention provides a sampling device for rat brain tissue samples, comprising:
the base is provided with an upright column on one side of the top of the base, a cross beam is arranged on the top of the upright column, one end of the cross beam extends to the middle of the base from the other side of the base, an installation cavity is arranged on the top of the base and is rectangular, first slide ways are arranged on the side walls of the left side and the right side of the installation cavity, and second slide ways are arranged on the side walls of the front side and the rear side of the installation cavity;
the first guide rod is fixedly arranged in the first slide way;
the first screw is rotatably arranged in the other first slide way;
the first knob is arranged on one side of the base and is fixedly connected with one end of the first screw rod;
the second guide rod is fixedly arranged in the second slide way;
the second screw rod is rotatably arranged in the other second slide way;
the second knob is arranged on one side of the base and is fixedly connected with one end of the second screw rod;
the first sliding frame and the second sliding frame are rectangular, the first sliding frame and the second sliding frame are arranged in the installation cavity in a crossed mode and enclose a rectangular placement cavity, one end of the first sliding frame is connected with the first guide rod in a sliding mode, the other end of the first sliding frame is connected with the first screw in a threaded mode, one end of the second sliding frame is connected with the second guide rod in a sliding mode, and the other end of the second sliding frame is connected with the second screw in a threaded mode;
the placing table is matched with the placing cavity, and the placing table is arranged in the placing cavity and is in sliding connection with the base;
the sleeve is fixedly arranged at one end of the cross beam, which is far away from the upright post;
the sampling tube is arranged in the sleeve in a sliding mode, two ends of the sampling tube extend out of the sleeve, and a limiting part is arranged on the outer wall of the sampling tube;
the reset spring is sleeved outside the sampling tube, two ends of the reset spring are respectively abutted against the bottom end of the sleeve and the limiting part, and the reset spring has a tendency of enabling the sampling tube to move upwards in a natural state; and
the cavity die head is detachably arranged at the bottom end of the sampling tube and communicated with the sampling tube, the bottom of the cavity die head is opened, and the bottom of the side wall of the cavity die head is provided with a cutting edge; and
and the positive and negative pressure device is fixedly arranged on the cross beam and is communicated with the sampling tube through a hose.
Further, a plurality of transverse separation lines and a plurality of longitudinal separation lines which are vertically crossed are arranged on the top surface of the placing table.
Furthermore, the top surface of the base is provided with transverse displacement scale marks and longitudinal displacement scale marks, and the first sliding frame and the second sliding frame are respectively provided with reference scale marks matched with the transverse displacement scale marks and the longitudinal displacement scale marks.
Further, the top end of the sampling tube is provided with a pressing cap.
Furthermore, the first sliding frame is provided with a slide way along the length direction of the first sliding frame, and the second sliding frame is connected with the first sliding frame in a sliding mode through the slide way.
Further, the cavity die head is connected with the sampling tube through threads.
Further, the top of the cavity die head is provided with a plurality of through holes, and the cavity die head is communicated with the sampling tube through the through holes.
The utility model has the advantages that:
the utility model provides a sampling device of rat brain tissue sample can change the position of placing the platform through rotatory first knob and second knob to make and place the sliced section of sample part of treating of rat brain tissue of placing the bench and aim at the die head of die cavity, and then realized the accurate counterpoint and the quick sample of sample. Meanwhile, the cutting edge is arranged at the bottom of the cavity die head, so that the brain tissue is less damaged during sampling, and the repeatability of the experiment is improved.
Drawings
In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings used in the embodiments or the technical solutions in the prior art will be briefly described below. Throughout the drawings, like elements or portions are generally identified by like reference numerals. In the drawings, elements or portions are not necessarily drawn to scale.
Fig. 1 is a perspective view of a sampling device for rat brain tissue samples according to an embodiment of the present invention;
FIG. 2 is a front view of the rat brain tissue sample sampling device shown in FIG. 1;
FIG. 3 is a cross-sectional view taken along line A-A of FIG. 2;
FIG. 4 is a cross-sectional view taken along line B-B of FIG. 3;
FIG. 5 is a cross-sectional view taken along line C-C of FIG. 2;
FIG. 6 is an enlarged view at D of FIG. 3;
fig. 7 is an enlarged view at E shown in fig. 3.
Reference numerals:
010-base, 011-upright post, 012-cross beam, 013-installation cavity, 014-first slide way, 015-second slide way, 016-transverse displacement scale line, 017-longitudinal displacement scale line, 020-first guide bar, 030-first screw rod, 040-first knob, 050-second guide bar, 060-second screw rod, 070-second knob, 080-first sliding frame, 081-slide way, 090-second sliding frame, 100-placing table, 101-transverse separation line, 102-longitudinal separation line, 110-sleeve, 120-sampling tube, 121-limiting part, 122-pressing cap, 130-reset spring, 140-cavity die head, 141-cutting edge, 142-through hole, 150-positive and negative pressure device, 001-placing cavity, 002-reference scale mark.
Detailed Description
Embodiments of the present invention will be described in detail below with reference to the accompanying drawings. The following examples are only for illustrating the technical solutions of the present invention more clearly, and therefore are only examples, and the protection scope of the present invention is not limited thereby.
It is to be noted that unless otherwise specified, technical or scientific terms used herein shall have the ordinary meaning as understood by those skilled in the art to which the present invention belongs.
In the description of the present application, it is to be understood that the terms "center," "longitudinal," "lateral," "length," "width," "thickness," "upper," "lower," "front," "rear," "left," "right," "vertical," "horizontal," "top," "bottom," "inner," "outer," "clockwise," "counterclockwise," "axial," "radial," "circumferential," and the like are used in the orientations and positional relationships indicated in the drawings for convenience of description and simplicity of description, and are not intended to indicate or imply that the referenced devices or elements must have a particular orientation, be constructed and operated in a particular orientation, and are therefore not to be considered limiting.
Furthermore, the terms "first", "second", etc. are used for descriptive purposes only and are not to be construed as indicating or implying relative importance or implicitly indicating the number of technical features indicated. In the description of the present invention, "a plurality" means two or more unless specifically limited otherwise.
In this application, unless expressly stated or limited otherwise, the terms "mounted," "connected," "secured," and the like are to be construed broadly and can include, for example, fixed connections, removable connections, or integral parts; can be mechanically or electrically connected; either directly or indirectly through intervening media, either internally or in any other relationship. The specific meaning of the above terms in the present invention can be understood according to specific situations by those skilled in the art.
In this application, unless expressly stated or limited otherwise, the first feature "on" or "under" the second feature may be directly contacting the first and second features or indirectly contacting the first and second features through intervening media. Also, a first feature "on," "over," and "above" a second feature may be directly or diagonally above the second feature, or may simply indicate that the first feature is at a higher level than the second feature. A first feature being "under," "below," and "beneath" a second feature may be directly under or obliquely under the first feature, or may simply mean that the first feature is at a lesser elevation than the second feature.
As shown in fig. 1-7, the utility model provides a sampling device for rat brain tissue sample, including base 010, first guide bar 020, first screw 030, first knob 040, second guide bar 050, second screw 060, second knob 070, first sliding frame 080, second sliding frame 090, place platform 100, sleeve 110, sampling tube 120, reset spring 130, die head 140 and positive and negative pressure device 150.
Wherein, one side fixedly connected with stand 011 at the top of base 010, the top of this stand 011 is connected with crossbeam 012, and the one end of this crossbeam 012 extends to the middle part of base 010 to the other side of base 010, and installation cavity 013 has been seted up at the top of base 010, and specifically, installation cavity 013 is rectangle and open-top, and first slide 014 has all been seted up to the lateral wall of the left and right sides of installation cavity 013, and second slide 015 has all been seted up to the lateral wall of the front and back both sides of installation cavity 013.
The first guiding bar 020 is fixedly mounted in a first slideway 014. The first threaded rod 030 is rotatably mounted in the other first slideway 014. The first knob 040 is located on one side of the base 010 and is fixedly connected with one end of the first bolt 030, so that the first bolt 030 can be driven to rotate by rotating the first knob 040. The second guide bar 050 is fixedly disposed within a second slideway 015. The second screw 060 is rotatably provided in the other second slide 015. The second knob 070 is located on one side of the base 010 and is fixedly connected to one end of the second screw 060, so that the second screw 060 can be driven to rotate by rotating the second knob 070.
The first sliding frame 080 and the second sliding frame 090 are rectangular, the first sliding frame 080 and the second sliding frame 090 are installed and slide in the installation cavity 013, the first sliding frame 080 and the second sliding frame 090 are perpendicular to each other and intersect to form a rectangular placing cavity 001 in a surrounding mode, one end of the first sliding frame 080 is connected with the first guide rod 020 in a sliding mode, the other end of the first sliding frame 080 is connected with the first screw 030 in a threaded mode, one end of the second sliding frame 090 is connected with the second guide rod 050 in a sliding mode, and the other end of the second sliding frame 090 is connected with the second screw 060 in a threaded mode. The placing table 100 is adapted to the placing cavity 001, and the placing table 100 is installed in the placing cavity 001 and slidably connected to the base 010.
Thus, the positions of the first and second sliding frames 080 and 090 can be changed by rotating the first and second knobs 040 and 070, and the transverse and longitudinal positions of the placing table 100 can be changed to align the portion of the rat brain tissue slice to be sampled with the cavity mold head 140, thereby improving the accuracy and the positioning of the sampling position.
Specifically, when the first knob 040 is rotated, the first screw 030 turns together with the first knob 040, and the first slide frame 080 is prevented from turning by the first guide bar 020 and the first slide rail 014, so that the first screw 030 moves the first slide frame 080 and the placement stage 100 is carried by the first slide frame 080.
Similarly, when the second knob 070 is rotated, the second screw rod 060 rotates together with the second knob 070, and the second slide frame 090 cannot rotate under the action of the second guide bar 050 and the second slide 015, so that the second slide frame 090 is driven to move by the action of the second screw rod 060, and the placing table 100 is carried by the second slide frame 090.
The sleeve 110 is fixedly mounted on the end of the cross beam 012 remote from the column 011. The sampling tube 120 is slidably mounted in the sleeve 110, two ends of the sampling tube 120 extend out of the sleeve 110, and the outer wall of the sampling tube 120 is provided with a limiting portion 121. The reset spring 130 is sleeved outside the sampling tube 120, and two ends of the reset spring 130 are respectively abutted against the bottom end of the sleeve 110 and the limiting part 121, and in a natural state, the reset spring 130 has a tendency of making the sampling tube move upwards.
The cavity die head 140 is detachably mounted to the bottom end of the sampling tube 120 and communicates with the sampling tube 120. The cavity die head 140 is detachably connected to the sampling tube 120, facilitating replacement of different cavity die heads 140. The cavity die head 140 may be of different sizes and shapes, with different shapes of the cavity die head 140 depending on the brain region, brain nuclei. The bottom of the cavity die head 140 is open and the bottom of the sidewall of the cavity die head 140 is provided with a cutting edge 141, which reduces the damage to the tissue near the sampling point during sampling. The positive and negative pressure device 150 is fixedly mounted on the cross beam 012, and an air inlet of the positive and negative pressure device 150 is communicated with the sampling tube 120 through a hose. The positive and negative pressure device can form positive pressure and negative pressure in the sampling tube. Specifically, during sampling, negative pressure is first formed in the sampling tube 120 and the cavity die head 140 by the positive and negative pressure device 150 to adsorb the sampled brain tissue in the cavity die head 140, then the placing table or the sampling tube is removed, then the device for containing the sample is placed below the cavity die head, and positive pressure is formed in the cavity die head by the positive and negative pressure device, so that the sampled sample is blown out of the cavity die head.
In one embodiment, the top surface of the standing board 100 is arranged with a plurality of transverse separation lines 101 and a plurality of longitudinal separation lines 102 intersecting perpendicularly. The placing table 100 is divided into a plurality of small areas by arranging the transverse separation lines 101 and the longitudinal separation lines 102, so that the position of the area to be sampled on the rat brain tissue section on the placing table 100 is determined through the small areas, and the area only needs to be moved to the position below the cavity die head 140 during sampling to achieve the purpose of accurate sampling.
In one embodiment, the top surface of the base 010 is provided with lateral displacement markings 016 and longitudinal displacement markings 017, which facilitate precise control of the displacement of the placement table 100. The first and second slide frames 080 and 090 are respectively provided with a reference graduation line 002 which is matched with the transverse displacement graduation line 016 and the longitudinal displacement graduation line 017, and preferably, the straight line where the reference graduation line 002 on the first and second slide frames 080 and 090 is located intersects at the central position of the placing table 100, so that the placing table 100 is divided into four large regions, which facilitates the determination of the transverse and longitudinal moving directions of the placing table 100 according to the position of the region to be sampled of the rat brain tissue section on the placing table 100, and the transverse and longitudinal moving distances of the placing table 100 are determined according to the transverse separation lines 101 and the longitudinal separation lines 102. And the starting scale mark, namely the zero scale mark, of the transverse displacement scale mark 016 and the longitudinal displacement scale mark 017 on the base 010 is positioned in the middle of the base 010, namely the straight line where the zero scale mark is positioned intersects at the central position of the base 010, so that when the reference scale mark 002 on the first sliding frame 080 and the second sliding frame 090 respectively corresponds to the zero scale mark of the transverse displacement scale mark 017 and the center of the placing table 100 is positioned under the cavity mold head 140, the transverse and longitudinal moving directions and distances of the placing table 100 can be conveniently determined according to the positions of the region to be sampled of the rat brain tissue slices on the placing table 100.
This structure facilitates better adjustment and positioning of the placement stage 100, thereby further improving the accuracy and the positioning of the sampling region, and confirming the initial position of the placement stage 100, that is, the positions of the reference graduation lines 002 of the first and second slide frames 080 and 090 corresponding to the lateral displacement graduation lines 016 and the longitudinal displacement graduation lines 017, respectively.
In one embodiment, the tip of the sampling tube 120 is provided with a press cap 122. To facilitate pressing.
In one embodiment, the first sliding frame 080 is provided with a slide 081 along the length direction thereof, and the second sliding frame 080 is slidably connected with the first sliding frame 081 through the slide 081. This structure allows the first slide frame 080 and the second slide frame 090 to be better fitted to the placement table 100.
In one embodiment, cavity die head 140 is threadably connected to sampling tube 120. This structure is convenient for dismantle and installation.
In one embodiment, the top of the cavity die head 140 is formed with a plurality of through holes 142, and the cavity die head 140 communicates with the sampling tube 120 through the through holes 142. This configuration can reduce negative pressure suction, thereby reducing damage to the sampled brain tissue.
In one embodiment, the lower end of the sampling tube 120 is fitted with a sealing ring. Thus, after screwing the cavity die head 140, the cavity die head 140 presses the sealing ring to improve sealability.
The working principle of the utility model is as follows:
in use, the placing table 100 is first adjusted to a corner of the installation cavity 013 by adjusting the first knob 040 and the second knob 070, then the rat brain tissue slice is placed on the placing table 100, and then the position of the region to be sampled of the rat brain tissue slice on the placing table 100 is confirmed to determine the moving direction and distance of the placing table 100 with respect to the horizontal direction and the vertical direction at the initial position.
Then, the placing table 100 is restored to the initial position by adjusting the first knob 040 and the second knob 070.
Then, the first knob 040 and the second knob 070 are adjusted so that the placing table 100 is moved in accordance with the previously confirmed moving distance and direction of the placing table 100 in the lateral direction and the longitudinal direction.
Finally, the positive and negative pressure device 150 is started and the pressing cap 122 is pressed, so that the sampling tube 120 moves downwards, thereby carrying the cavity mold head 140 to move downwards, so that the cutting blade 141 cuts off the rat brain tissue, and the rat brain tissue sample is absorbed in the cavity mold head 140 under the action of the positive and negative pressure device 150.
In the specification of the present invention, a large number of specific details are explained. It is understood, however, that embodiments of the invention may be practiced without these specific details. In some instances, well-known methods, structures and techniques have not been shown in detail in order not to obscure an understanding of this description.
Finally, it should be noted that: the above embodiments are only used to illustrate the technical solution of the present invention, and not to limit the same; although the present invention has been described in detail with reference to the foregoing embodiments, it should be understood by those skilled in the art that: the technical solutions described in the foregoing embodiments may still be modified, or some or all of the technical features may be equivalently replaced; such modifications and substitutions do not substantially depart from the scope of the embodiments of the present invention, and are intended to be covered by the claims and the specification.
Claims (7)
1. A sampling device of rat brain tissue sample, which is characterized in that: the method comprises the following steps:
the base is provided with an upright column on one side of the top of the base, a cross beam is arranged on the top of the upright column, one end of the cross beam extends to the middle of the base from the other side of the base, an installation cavity is arranged on the top of the base and is rectangular, first slide ways are arranged on the side walls of the left side and the right side of the installation cavity, and second slide ways are arranged on the side walls of the front side and the rear side of the installation cavity;
the first guide rod is fixedly arranged in the first slide way;
the first screw is rotatably arranged in the other first slide way;
the first knob is arranged on one side of the base and is fixedly connected with one end of the first screw rod;
the second guide rod is fixedly arranged in the second slide way;
the second screw rod is rotatably arranged in the other second slide way;
the second knob is arranged on one side of the base and is fixedly connected with one end of the second screw rod;
the first sliding frame and the second sliding frame are rectangular, the first sliding frame and the second sliding frame are arranged in the installation cavity in a crossed mode and enclose a rectangular placement cavity, one end of the first sliding frame is connected with the first guide rod in a sliding mode, the other end of the first sliding frame is connected with the first screw in a threaded mode, one end of the second sliding frame is connected with the second guide rod in a sliding mode, and the other end of the second sliding frame is connected with the second screw in a threaded mode;
the placing table is matched with the placing cavity, and the placing table is arranged in the placing cavity and is in sliding connection with the base;
the sleeve is fixedly arranged at one end of the cross beam, which is far away from the upright post;
the sampling tube is arranged in the sleeve in a sliding mode, two ends of the sampling tube extend out of the sleeve, and a limiting part is arranged on the outer wall of the sampling tube;
the reset spring is sleeved outside the sampling tube, two ends of the reset spring are respectively abutted against the bottom end of the sleeve and the limiting part, and the reset spring has a tendency of enabling the sampling tube to move upwards in a natural state; and
the cavity die head is detachably arranged at the bottom end of the sampling tube and communicated with the sampling tube, the bottom of the cavity die head is opened, and the bottom of the side wall of the cavity die head is provided with a cutting edge; and
and the positive and negative pressure device is fixedly arranged on the cross beam and is communicated with the sampling tube through a hose.
2. A rat brain tissue sample sampling device according to claim 1, wherein: the top surface of the placing table is provided with a plurality of transverse separation lines and a plurality of longitudinal separation lines which are vertically crossed.
3. A rat brain tissue sample sampling device according to claim 2, characterized in that: the top surface of base is provided with lateral displacement scale mark and longitudinal displacement scale mark, just first sliding frame with be provided with respectively on the second sliding frame with lateral displacement scale mark with longitudinal displacement scale mark matched with benchmark scale mark.
4. A rat brain tissue sample sampling device according to claim 1, wherein: the top end of the sampling tube is provided with a pressing cap.
5. A rat brain tissue sample sampling device according to claim 1, wherein: the first sliding frame is provided with a slide way along the length direction of the first sliding frame, and the second sliding frame is connected with the first sliding frame in a sliding mode through the slide way.
6. A rat brain tissue sample sampling device according to claim 1, wherein: the cavity die head is connected with the sampling tube through threads.
7. A rat brain tissue sample sampling device according to claim 1, wherein: the top of die cavity mould head is provided with a plurality of through-holes, die cavity mould head passes through the through-hole with the sampling tube intercommunication.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202120553153.4U CN214621797U (en) | 2021-03-18 | 2021-03-18 | Sampling device of rat brain tissue sample |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202120553153.4U CN214621797U (en) | 2021-03-18 | 2021-03-18 | Sampling device of rat brain tissue sample |
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| Publication Number | Publication Date |
|---|---|
| CN214621797U true CN214621797U (en) | 2021-11-05 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202120553153.4U Active CN214621797U (en) | 2021-03-18 | 2021-03-18 | Sampling device of rat brain tissue sample |
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| CN (1) | CN214621797U (en) |
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- 2021-03-18 CN CN202120553153.4U patent/CN214621797U/en active Active
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