CN214593487U - General metabolism cage of big mouse - Google Patents

Abstract

The utility model provides a general metabolism cage of big mouse and little mouse, include: a feeding assembly, a manure separator and a collection unit. The feeding assembly is arranged above the excrement-urine separator, and the collecting unit is arranged below the excrement-urine separator. The collecting unit comprises a storage box and a collecting assembly, a connecting hole is formed in the top surface of the storage box, and the connecting hole is communicated with a urine guide pipe at the bottom of the excrement-urine separator. The collection assembly is arranged inside the storage box and comprises a collection disc and a controller, a plurality of urine collection test tubes which are annularly arranged are arranged on the collection disc, and the collection disc can be driven to rotate through the controller, so that different urine collection test tubes are aligned with the connecting holes in a preset time period. A general metabolism cage of big mouse, researcher's time cost can be practiced thrift, the metabolite sample of many time nodes is regularly gathered to promote the accurate degree of metabolism experimental result.

Description

General metabolism cage of big mouse

Technical Field

The utility model belongs to the experimental facilities field especially relates to a general metabolism cage of big mouse and little mouse.

Background

In the prior art, the experimental mouse has the advantages of good biological stability, easy replication of a disease model, low experimental cost and the like, so the experimental mouse is widely applied to the research process of physiological, pharmacological, metabolic diseases and the like. In conducting the study, researchers needed to raise laboratory mice in metabolic cages. The traditional metabolism cage mainly comprises a laboratory mouse feeding area and a fecaluria separation area, when a laboratory mouse generates metabolites (urine and excrement), the fecaluria separation area can separate the urine and the excrement, and researchers can extract the urine or the excrement according to actual needs, so that the metabolism condition of medicines or nutrient substances in an animal body is researched.

However, the existing metabolism cage is poor in use convenience, and the collection work of a plurality of samples cannot be continuously carried out. When the change rule of the metabolites of the laboratory mice needs to be researched, researchers only can consume a large amount of time and cost to carry out manual sampling. However, the time node of manual sampling is easy to have an error with the preset time node, so that a researcher misjudges the metabolic process of the experimental mouse, and the accuracy of the experimental result is further influenced. In addition, the existing metabolism cage is easy to cause sample pollution in the using process, the pollution source of the metabolism cage can come from leakage of drinking water or food residues of experimental rats, bacteria bred due to deterioration of the sample in the storage process can be generated, and meanwhile, some objects to be detected are easy to decompose or inactivate at normal temperature. The accuracy of the experimental results is further reduced because contamination or inactivation of the sample can cause changes in its internal components.

SUMMERY OF THE UTILITY MODEL

In view of this, the present invention provides a metabolism cage for big and small mice, so as to solve the above technical problems.

In order to achieve the above purpose, the technical scheme of the utility model is realized like this:

a universal metabolism cage for rats and mice, comprising:

a feeding assembly comprising: the feeding device comprises a feeding cage, a feeder and a water feeder, wherein a bearing net is arranged at the bottom of the feeding cage, and the feeder and the water feeder are detachably arranged on the side wall of the feeding cage;

the excrement-urine separator is arranged at the bottom of the rearing cage, and a urine guide pipe and an excrement collecting barrel are arranged at the bottom of the excrement-urine separator;

the collecting unit comprises a storage box and a collecting assembly, the storage box is arranged below the excrement separator, a partition plate is arranged in the storage box, a collecting cavity is formed above the partition plate, and an equipment cavity is formed below the partition plate; the top surface of the storage box is provided with a connecting hole, and the urine guide pipe is communicated with the connecting hole; the collecting assembly comprises a collecting tray and a controller, the collecting tray is arranged in the collecting cavity, and the collecting tray is provided with a plurality of urine collecting test tubes which are annularly arranged; the controller sets up inside equipment cavity, drives the catch tray through the controller and rotates to make different collection urine test tubes align with the connecting hole in the time quantum of predetermineeing.

Furthermore, the metabolism cage comprises an isolation assembly, the isolation assembly is arranged inside the rearing cage and comprises a middle shaft and two isolation plates, the two isolation plates are hinged with the side wall of the central shaft, and a rearing area is formed between the two isolation plates; the feeding area is aligned with the urine guide pipe, and the feeder and the water feeder are communicated with the feeding area.

Furthermore, the isolation assembly comprises a fixing piece and a supporting plate, wherein the fixing piece is arranged at the top of the isolation plate, a plurality of fixing holes are formed in the fixing piece, and the fixing holes are annularly arranged on the periphery of the central shaft; the supporting plate is arranged outside the feeding area, and one side of the supporting plate is hinged with the side wall of the central shaft; the top surface of the isolation plate is provided with a first fixing protrusion, the top surface of the supporting plate is provided with a second fixing protrusion, and the first fixing protrusion and the second fixing protrusion are inserted into the fixing holes.

Further, the feeder comprises: feed and eat casing, support groove and feed box, it is equipped with first interception net on the bottom surface of feeding the casing to feed, the bearing groove slides and sets up in the bottom of feeding the casing, and the top surface of bearing groove is located the below of first interception net, feed box slides and sets up inside feeding the casing, and is equipped with the laboratory mouse fodder in feed box.

Furthermore, the feed box comprises a second intercepting net, and a recovery groove and a feed groove which are arranged in a step shape, wherein the feed groove is positioned above the recovery groove, and a feed outlet is formed in the side wall of the feed groove close to the recovery groove; the second interception net comprises a horizontal section and an inclined section, the horizontal section is arranged on the top surface of the recovery tank, the horizontal section is located below the first interception net, the inclined section is arranged inside the feed outlet, and the top of the inclined section inclines towards the direction of the feed trough.

Further, the water feeder comprises: the water feeding device comprises a water feeding shell, a containing support, a water feeding bottle and a recovery assembly, wherein the containing support is arranged on the side wall of the water feeding shell, the water feeding bottle is arranged in the containing support, and a bottle mouth of the water feeding bottle is inserted into the water feeding shell; retrieve the subassembly and set up in the below of feeding the water casing, be equipped with on the bottom surface of feeding the water casing and retrieve the incision, retrieve the inside third interception net that is equipped with of incision, and retrieve the subassembly and be linked together through retrieving the incision and feeding the water casing.

Furthermore, the recovery assembly comprises a flow guide channel and a recovery bottle, the flow guide channel is arranged at the bottom of the water feeding shell, and the flow guide channel is communicated with the water feeding shell through a recovery notch; be equipped with the water conservancy diversion mouth on the bottom surface of water conservancy diversion passageway, retrieve bottle detachable and install on the water conservancy diversion mouth, can retrieve the drinking water that leaks through the cooperation of water conservancy diversion mouth and recovery bottle.

Further, the manure separator comprises: the excrement collecting barrel and the urine guide pipe are arranged on the bottom surface of the outer barrel body;

the inner cylinder body comprises a collecting funnel and a flow guide funnel, the large end of the collecting funnel is upward, the large end of the flow guide funnel is downward, and the small end of the collecting funnel is communicated with the small end of the flow guide funnel; a diversion groove is arranged on the inner wall of the large end of the diversion funnel, and an included angle is formed between the diversion groove and the horizontal plane; the opening end of the excrement collecting cylinder is inserted into the flow guide funnel, and the axis of the excrement collecting cylinder is coincided with the axis of the flow guide funnel; a nozzle is arranged at one end of the diversion groove close to the bottom surface of the outer cylinder body and communicated with the urine guide pipe;

the downward setting of separation awl opening is inside collecting the funnel, and the external diameter of separation awl opening side is greater than the tip internal diameter of collecting the funnel to be less than the main aspects internal diameter of collecting the funnel.

Furthermore, the partition plate is provided with an installation cutting groove, a semiconductor refrigerator is arranged in the installation cutting groove, the cold end of the semiconductor refrigerator is arranged in the collection cavity, the hot end of the semiconductor refrigerator is arranged in the equipment cavity, and the hot end of the semiconductor refrigerator is provided with a radiator.

Furthermore, the metabolism cage comprises an assembling component, the assembling component comprises an upper support frame and a lower support frame, and the upper support frame is detachably arranged at the top of the lower support frame; the rearing cage and the excrement-urine separator are arranged on the upper supporting frame, and the preservation box is arranged on the lower supporting frame.

Compared with the prior art, the utility model a general metabolism cage of big mouse have following advantage:

(1) a general metabolism cage of big mouse, rotation that can pass through the catch tray makes different collection urine test tubes well mutually with the connecting hole in the time quantum of predetermineeing to the urine sample of laboratory mouse is gathered according to predetermineeing the time point pair. Compared with the prior art, the device can automatically collect the metabolite samples of each time node, and does not need to be watched by researchers for a long time, so that the time error caused by manual sample collection can be avoided, and the accuracy of the experimental result is improved. In addition, because the collection work of metabolite can be realized automatically to this device, consequently can also avoid the laboratory mouse to cause emergent reaction because of human intervention to avoid the experimental result error to appear.

(2) A general metabolism cage of big mouse, can leave a plurality of experimental samples inside collecting the cavity to adjust the temperature of preserving of sample through the semiconductor refrigerator. Compared with the prior art, this device can avoid the sample to receive external environment's pollution to through the preservation time of temperature regulation extension sample, prevent that it from taking place rotten, thereby further promoted the accurate degree of experimental result.

(3) A general metabolism cage of big mouse, the inner space of its feeder can be adjusted according to the volume of laboratory mouse to make the laboratory mouse get into the inside feed of feeder, prevent that food waste from causing the pollution to the metabolite sample. In addition, the water bowl in this device can also retrieve the drinking water that leaks through retrieving the subassembly to prevent that the drinking water that leaks from causing the pollution to the metabolite sample.

(4) A general metabolism cage of big mouse, can raise the region through keeping apart the subassembly at the inside formation of rearging cage, raise the home range that the region can restrict the laboratory mouse through setting up to reduce the distribution area of its metabolite, conveniently carry out the metabolite and gather.

(5) A general metabolism cage of big mouse, can realize dismantling of hutch and other subassemblies through assembling the subassembly and connect. When the device is used, a researcher can select the use mode of the device according to actual requirements, and therefore the use convenience of the device is improved.

Drawings

The accompanying drawings, which form a part hereof, are included to provide a further understanding of the invention, and are incorporated in and constitute a part of this specification, illustrate embodiments of the invention and together with the description serve to explain the invention without undue limitation. In the drawings:

FIG. 1 is a schematic structural diagram of a metabolic cage according to an embodiment of the present invention;

FIG. 2 is an exploded view of a metabolic cage according to an embodiment of the present invention;

fig. 3 is an exploded view of a feeding assembly (with the feeder and water feeder hidden) according to an embodiment of the present invention;

fig. 4 is a cross-sectional view of a feeding assembly (with the feeder and water feeder hidden) according to an embodiment of the present invention;

fig. 5 is an exploded view of a feeder according to an embodiment of the present invention;

fig. 6 is a cross-sectional view of a feeder according to an embodiment of the present invention;

FIG. 7 is an exploded view of a water feeder according to an embodiment of the present invention;

FIG. 8 is a cross-sectional view of a water feeder according to an embodiment of the present invention;

FIG. 9 is a cross-sectional view of a feces-urine separator according to an embodiment of the present invention;

FIG. 10 is a cross-sectional view of a feces-urine separator according to an embodiment of the present invention at another angle;

fig. 11 is a cross-sectional view of a collection unit according to an embodiment of the present invention;

fig. 12 is a schematic structural diagram of a collecting assembly according to an embodiment of the present invention.

Description of reference numerals:

1-a rearing cage; 11-a carrier web; 12-an intermediate shaft; 13-a separator plate; 131-a first fixing protrusion; 14-a support plate; 141-a second fixing projection; 15-fixing the sheet; 151-fixing holes; 2-a feeder; 21-feeding the shell; 211-a first interception net; 22-a support groove; 23-a recovery tank; 24-a trough; 251-a horizontal segment; 252-an inclined section; 3-water feeder; 31-water feeding shell; 311-a third interception net; 32-a containment bracket; 33-feeding bottle; 331-bottle mouth; 34-a flow guide channel; 341-a flow guide nozzle; 35-a fixed support; 36-recovery bottle; 41-outer cylinder; 421-a collection funnel; 422-a diversion funnel; 423-flow guide grooves; 424-nipple; 43-a separation cone; 44-a stool collection canister; 45-a urine catheter; 5-preservation of the box; 51-a divider plate; 52-a collection cavity; 53-equipment cavity; 54-connecting hole; 6-a collection tray; 61-urine collection tube; 62-a controller; 7-a semiconductor refrigerator; 71-a heat sink; 81-upper support frame; 82-lower support shelf.

Detailed Description

It should be noted that, in the present invention, the embodiments and features of the embodiments may be combined with each other without conflict.

In the description of the present invention, it is to be understood that the terms "center", "longitudinal", "lateral", "up", "down", "front", "back", "left", "right", "vertical", "horizontal", "top", "bottom", "inner", "outer", and the like, indicate orientations or positional relationships based on the orientations or positional relationships shown in the drawings, and are used merely for convenience of description and for simplicity of description, and do not indicate or imply that the device or element being referred to must have a particular orientation, be constructed and operated in a particular orientation, and therefore, should not be construed as limiting the present invention. Furthermore, the terms "first", "second", etc. are used for descriptive purposes only and are not to be construed as indicating or implying relative importance or implicitly indicating the number of technical features indicated. Thus, a feature defined as "first," "second," etc. may explicitly or implicitly include one or more of that feature. In the description of the present invention, "a plurality" means two or more unless otherwise specified.

In the description of the present invention, it is to be noted that, unless otherwise explicitly specified or limited, the terms "mounted," "connected," and "connected" are to be construed broadly, and may be, for example, fixedly connected, detachably connected, or integrally connected; can be mechanically or electrically connected; they may be connected directly or indirectly through intervening media, or they may be interconnected between two elements. The specific meaning of the above terms in the present invention can be understood by those of ordinary skill in the art through specific situations.

The present invention will be described in detail below with reference to the accompanying drawings in conjunction with embodiments.

The laboratory mouse metabolism cage is a common experimental device in the fields of life science and medicine, and is generally used for researching the metabolism condition of a laboratory mouse. In the experiment, researchers can raise the laboratory mice in the metabolism cage, provide enough drinking water and food for the laboratory mice, collect the metabolites (feces or urine) of the laboratory mice, and analyze the components and change rules of the metabolites to obtain the influence of the medicines or nutrients on the body of the laboratory mice.

However, the existing metabolism cage cannot continuously collect a plurality of samples, and when the change rule of the metabolites of the laboratory mouse needs to be researched, a large amount of time cost needs to be consumed by researchers for manual sampling. The time node of manual sampling is easy to have an error with the preset time node, and meanwhile, human interference can also generate certain stress response and the like to the experimental mouse, so that the researcher can misjudge the metabolic process of the experimental mouse. In addition, the existing metabolism cage is easy to cause sample pollution in the using process, the pollution source can be water leakage or food residue of experimental rats, and the pollution source can also be bacteria breeding due to deterioration of the sample in the storage process. Both of the above conditions will affect the data of the metabolic experiments, thereby reducing the accuracy of the experimental results.

In order to solve the above problems, the present embodiment provides a metabolism cage for rats and mice, as shown in fig. 1 and 2, the metabolism cage comprising: a feeding assembly, a manure separator and a collection unit. Can provide living space for the laboratory mouse through raising the subassembly, can separate excrement and urine in the metabolite through the excrement and urine separator, can retrieve and preserve the urine of laboratory mouse through the collection unit.

The feeding assembly comprises: the feeding cage comprises a feeding cage 1, a feeder 2 and a water feeder 3, wherein a bearing net 11 is arranged at the bottom of the feeding cage 1, and the feeder 2 and the water feeder 3 are detachably arranged on the side wall of the feeding cage 1. When carrying out experiments, the laboratory mouse living in the rearing cage 1 can move on the top surface of the bearing net 11, and after the laboratory mouse produces metabolites, the metabolites can move downwards along the meshes of the bearing net 11 so as to enter the excrement separator.

The excrement-urine separator is arranged at the bottom of the rearing cage 1, and a urine conduit 45 and an excrement collecting barrel 44 are arranged at the bottom of the excrement-urine separator. In the experiment, the metabolites entering the faeces and urine separator will undergo solid-liquid separation, wherein solid faeces enter the faeces collecting cylinder 44 and liquid urine flows along the urine conduit 45 towards the collecting unit.

Specifically, fig. 9 and 10 are sectional views of the feces-urine separator in the present embodiment, and as shown in the drawings, the feces-urine separator includes: an outer cylinder 41, an inner cylinder and a separation cone 43. The outer cylinder body 41 is sleeved outside the inner cylinder body, and the excrement collecting cylinder 44 and the urine guide pipe 45 are both arranged on the bottom surface of the outer cylinder body 41.

For conveniently realizing the separation of solid substance and liquid substance, interior barrel includes collection funnel 421 and water conservancy diversion funnel 422, and wherein the main aspects of collection funnel 421 is upwards, and the main aspects of water conservancy diversion funnel 422 are downwards, and the tip of collection funnel 421 communicates with the tip of water conservancy diversion funnel 422. The open end of the stool collection tube 44 is inserted into the guide funnel 422, and the axis of the stool collection tube 44 coincides with the axis of the guide funnel 422. The separation cone 43 is arranged inside the collection funnel 421 with the opening facing downward, and the outer diameter of the opening side of the separation cone 43 is larger than the inner diameter of the small end of the collection funnel 421 and smaller than the inner diameter of the large end of the collection funnel 421.

After the metabolites of the laboratory mouse enter the excrement and urine separating device, the metabolites will contact with the separating cone 43, and at this time, the liquid urine will flow along the outer wall of the separating cone 43 to the inner wall of the collecting funnel 421, and finally flow along the inner wall of the flow guiding funnel 422. The solid feces will fall down under the action of gravity and move down along the joint of the collection funnel 421 and the diversion funnel 422, and finally enter the feces collection cylinder 44.

In addition, for the convenience is collected the urine on the diversion funnel 422 inner wall, this embodiment is equipped with water conservancy diversion recess 423 on the main aspects inner wall of diversion funnel 422, there is the contained angle water conservancy diversion recess 423 and horizontal plane, still is equipped with connector 424 in the one end that water conservancy diversion recess 423 is close to outer barrel 41 bottom surface, connector 424 is linked together with urine pipe 45. After urine on the inner wall of the diversion funnel 422 enters the diversion groove 423, the urine will flow toward the connector 424 due to the included angle between the diversion groove 423 and the horizontal plane, and then will enter the urine conduit 45 along the connector 424 and finally flow toward the collection unit.

The collecting unit is arranged below the excrement-urine separator and comprises a storage box 5 and a collecting assembly, wherein the collecting assembly is arranged inside the storage box 5, collected samples can be contained through the storage box 5, the samples are prevented from being in direct contact with the external environment, timed collection of multiple samples can be achieved through the collecting assembly, the time cost of researchers is saved, and the accuracy degree of sampling time nodes is improved.

FIG. 11 is a sectional view of the collection unit, wherein a partition plate 51 is provided inside the preservation box 5, a collection cavity 52 is formed above the partition plate 51 for preserving the metabolite sample, and an equipment cavity 53 is formed below the partition plate 51 for accommodating relevant control equipment in the device. The top surface of the storage box 5 is provided with a connecting hole 54, and the urine guide tube 45 is communicated with the connecting hole 54, so that the urine of the laboratory mouse can be conveniently collected and stored.

Fig. 12 shows a schematic structure of a collecting assembly, which comprises a collecting tray 6 and a controller 62, wherein the collecting tray 6 is arranged inside the collecting cavity 52, and a plurality of urine collecting test tubes 61 arranged in a ring shape are arranged on the collecting tray 6. The controller 62 is disposed inside the apparatus cavity 53, and the collecting tray 6 is driven to rotate by the controller 62, so that different urine collecting tubes 61 are aligned with the connecting holes 54 for a predetermined period of time.

For example, in this embodiment, the controller 62 may include a servo motor and a timer, and the collecting tray 6 is connected to an output shaft of the servo motor. Before performing the experiment, the researcher can set the rotation time interval of the collecting tray 6 by a timer, and set the rotation angle of the servo motor according to the number of urine collecting test tubes 61. After the experiment starts, the controller 62 can drive the collection tray 6 to rotate according to the preset time interval, so that different urine collection test tubes 61 are aligned with the connection holes 54 within the preset time period, and the metabolites of the laboratory mouse at the time node are collected.

Compared with the prior art, the device can save the time cost of researchers through the timing rotation of the collecting tray 6, and the time accuracy of the multi-sample collection work is improved, so that the researchers are prevented from misjudging the metabolism process of the experimental mouse, and the accuracy of the metabolism experimental result is improved.

Optionally, because the sample collection period of the plurality of time nodes is long, in order to prevent the sample from deteriorating, the semiconductor refrigerator 7 is further disposed inside the storage box 5 in this embodiment, and the temperature of the collection cavity 52 can be controlled through the semiconductor refrigerator 7, so that the sample storage time is prolonged.

Specifically, a mounting slot may be formed on the partition plate 51, the semiconductor refrigerator 7 is disposed inside the mounting slot, the cold end of the semiconductor refrigerator 7 is disposed inside the collection cavity 52, the hot end of the semiconductor refrigerator is disposed inside the device cavity 53, and a heat sink 71 is further disposed at the hot end of the semiconductor refrigerator 7. When the semiconductor refrigerator 7 is energized, the cold end of the refrigerator will release cold, thereby lowering the temperature inside the collection cavity 52 and prolonging the storage time of the sample. Accordingly, the hot end of the semiconductor cooler 7 will release heat, and the heat can be dissipated through the heat sink 71, so as to ensure that the cold end has good cooling effect. In addition, researchers can control the refrigerating capacity in the collecting cavity 52 by adjusting the input current of the semiconductor refrigerator 7, so that the device is suitable for different working conditions.

In practice, other temperature adjustment methods may be used by the researchers to adjust the temperature inside the collection cavity 52, so as to prolong the storage time of the sample. It should be noted that when the preservation time of the sample is prolonged by the temperature adjustment device, the inside of the collection cavity 52 should be provided with an insulation layer, so as to reduce the heat exchange speed between the collection cavity 52 and the external environment.

Optionally, in order to reduce the distribution range of the metabolites of the laboratory mouse and avoid the waste of the metabolites in the excrement-urine separator, the metabolism cage in this embodiment further comprises an isolation component, and the isolation component is disposed in the metabolism cage. As shown in fig. 3 and 4, the isolation assembly comprises an intermediate shaft 12 and two isolation plates 13, both of said isolation plates 13 being hinged to the side walls of the central shaft and forming a feeding area between the two isolation plates 13. The feeding area is opposite to the urine guide tube 45, and the feeder 2 and the water feeder 3 are both communicated with the feeding area.

When carrying out experiments, researchers can adjust the included angle between the two partition plates 13 as required, thereby adjusting the internal space of the feeding area. When the laboratory mouse is placed in the breeding area, the activity space of the laboratory mouse is limited. By the method, the distribution range of the metabolites of the laboratory mice can be reduced, so that the metabolites can be conveniently collected.

In addition, to improve the structural strength of the feeding area, the insulation assembly may further include fixing pieces 15 and a support plate 14. Specifically, the fixing piece 15 is disposed on the top of the partition plate 13, and a plurality of fixing holes 151 are provided in the fixing piece 15, and the plurality of fixing holes 151 are annularly disposed on the periphery side of the central axis. The supporting plate 14 is arranged outside the feeding area, one side of the supporting plate 14 is hinged to the side wall of the central shaft, a first fixing protrusion 131 is arranged on the top surface of the isolation plate 13, a second fixing protrusion 141 is arranged on the top surface of the supporting plate 14, and the first fixing protrusion 131 and the second fixing protrusion 141 are inserted into the fixing hole 151.

Can promote division board 13 through setting up backup pad 14 and place stability, avoid division board 13 to take place to empty because of the activity of laboratory mouse. The rotation freedom of the isolation plate 13 can be limited by arranging the fixing plate 15, so that the isolation plate 13 is prevented from rotating due to the movement of a laboratory mouse.

As an optional implementation of this embodiment, the apparatus may further comprise a splicing assembly. Specifically, the assembly component comprises an upper support frame 81 and a lower support frame 82, the upper support frame 81 is detachably mounted at the top of the lower support frame 82, the rearing cage 1 and the excrement separator are mounted on the upper support frame 81, and the preservation box 5 is mounted on the lower support frame 82. The assembly component is used for realizing the detachable connection of the storage box and other components. When the device is used, a researcher can select the use mode of the device according to actual requirements, and therefore the use convenience of the device is improved.

Illustratively, when the automatic metabolite collection work is carried out, the preservation box can be communicated with the excrement-urine separator through the splicing of the upper support frame and the lower support frame, so that the automatic collection and preservation of the metabolites are realized. When carrying out manual teaching, but exclusive use upper bracket, excrement and urine separator and feeding subassembly to be convenient for carry out the demonstration of teaching content. When carrying out the multiunit contrast experiment, the assembly of researcher accessible upper and lower support frame is dismantled, and the control unit is unified to be set for, carries out the metabolite with the parallelly connected metabolite of different group's metabolism cages and collects to reduce interference factor between each experimental group, further promote the experiment accuracy.

In addition, because collection subassembly and semiconductor cooler all set up in the hutch, the cost of hutch is higher, and in the in-service use in-process of carrying out, the researcher can purchase a plurality of components of raising and excrement and urine separator, makes it use with a case of keeping in coordination to reduce laboratory mouse metabolism research's economic cost.

Fig. 5 and fig. 6 are schematic diagrams of the feeding device 2 in this embodiment, in order to avoid contamination of the metabolite sample by food residues generated by feeding of the laboratory rats, the feeding device 2 includes: a feeding shell 21, a supporting groove 22 and a feed box. Specifically, be equipped with first interception net 211 on the bottom surface of feeding casing 21, support groove 22 slides and sets up in the bottom of feeding casing 21, and the top surface of support groove 22 is located the below of first interception net 211, the fodder box slides and sets up inside feeding casing 21, and is equipped with the laboratory mouse fodder in the fodder box.

Before carrying out the experiment, the researcher can adjust the position of feed box according to laboratory mouse's size, and when the feed box outwards slided, feed the accommodation space of eating casing 21 inside and will promote, consequently enable the complete entering of laboratory mouse and feed the inside feed of casing 21 to avoid food waste to leak outward.

Optionally, to further improve the recovery capacity of the food residues, the feedbox comprises a second interception mesh and a recovery tub 23 and a feedbox 24 arranged in a step-like manner. Wherein the feed trough 24 is positioned above the recovery trough 23, and the side wall of the feed trough 24 close to the recovery trough 23 is provided with a feed outlet. The second intercepting net comprises a horizontal section 251 and an inclined section 252, the horizontal section 251 is arranged on the top surface of the recovering groove 23, the horizontal section 251 is positioned below the first intercepting net 211, the inclined section 252 is arranged in the feed outlet, and the top of the inclined section 252 is inclined towards the direction of the feed groove 24.

Can block the inside laboratory mouse fodder of fodder export through setting up slope section 252 to avoid laboratory mouse to bring food back to rearging cage 1 inside gnawing. Can extend first interception net 211 through setting up horizontal segment 251, when the feedbox outwards slides, horizontal segment 251 will form the platform that bears the weight of the laboratory mouse with first interception net 211 jointly to make things convenient for the great laboratory mouse of size to eat. In addition, when the laboratory mouse eats in the region of the horizontal section 251, food waste can enter the interior of the recovery tank 23, so that the waste collection capability of the device can be further improved.

Fig. 7 and 8 are schematic structural diagrams of the water feeder 3 in this embodiment, and in order to avoid pollution of leakage of water drinking of laboratory mice to metabolite samples, the water feeder 3 includes: a water feeding housing 31, a holding bracket 32, a water feeding bottle 33 and a recovery assembly. Specifically, the receiving bracket 32 is disposed on a side wall of the water feeding housing 31, the water feeding bottle 33 is mounted inside the receiving bracket 32, and the mouth 331 of the water feeding bottle 33 is inserted inside the water feeding housing 31. When drinking water is needed, the laboratory mouse can enter the inside of the water feeding housing 31 and lick the mouthpiece 331, thereby obtaining drinking water in the water feeding bottle 33.

However, the drinking water leakage is inevitably caused in the licking process under the influence of the water drinking mode of the laboratory rats. For convenient collection to the water that leaks, the below of feeding water casing 31 is equipped with retrieves the subassembly, and is equipped with on the bottom surface of feeding water casing 31 and retrieves the incision. The inside third interception net 311 that is equipped with of recovery incision, and retrieve the subassembly and be linked together through retrieving the incision and feeding the water casing 31.

When drinking water, the laboratory mouse will stand at third interception net 311 top, and the drinking water of revealing this moment will flow into along the mesh of third interception net 311 and retrieve inside the subassembly to avoid leaking drinking water and get into rearging cage 1, and cause the pollution to the metabolite sample.

Optionally, to enhance the recovery of the leaked water from the recovery assembly, the recovery assembly may include a diversion channel 34 and a recovery bottle 36. As shown in fig. 8, the guide passage 34 is provided at the bottom of the water feeding housing 31, and the guide passage 34 communicates with the water feeding housing 31 through the recovery slit. A diversion nozzle 341 is arranged on the bottom surface of the diversion channel 34, and the recovery bottle 36 is detachably mounted on the diversion nozzle 341.

When the drinking water leaks, the diversion channel 34 can guide the leaking drinking water into the interior of the recovery bottle 36. Since the diversion nozzle 341 is disposed at the bottom of the diversion channel 34, the leaked drinking water can be collected to the maximum extent in the recovery process of the leaked drinking water. After the experiment is completed, the drinking water consumption in the water feeding bottle 33 and the leakage drinking water recovery amount in the recovery bottle 36 can be calculated by researchers, so that the accurate water drinking amount of the laboratory mouse is obtained, and the metabolic condition of the laboratory mouse is conveniently analyzed.

In addition, in order to improve the stability of the connection between the recovery bottle 36 and the guide passage 34, the recovery assembly may further include a fixing bracket 35. Specifically, the fixing bracket 35 is disposed at the bottom of the diversion channel 34, and a claw for clamping the recovery bottle 36 may be disposed on the fixing bracket 35. When the device is used, the recovery bottle 36 can be stably fixed on the diversion nozzle 341 through the claws, so that the outflow of drinking water caused by the loosening of the recovery bottle 36 can be avoided.

Correspondingly, in order to further improve the sealing effect between the recovery bottle 36 and the flow guide nozzle 341, a researcher may further set an axial sealing ring and a radial sealing ring on the flow guide nozzle 341, where the axial sealing ring is set on the end surface of the flow guide nozzle 341, and the radial sealing ring is set on the side wall of the flow guide nozzle 341. Axial and radial sealed effect that can enable between recovery bottle 36 and water conservancy diversion mouth 341 through axial sealing washer and radial sealing washer to promote the degree of sealing between the two, avoid the drinking water to take place to reveal.

As a further optional implementation manner of this embodiment, in order to improve the automation degree of this device, the researcher may further set a sensor inside the device, so as to conveniently count the living state of the laboratory mouse. Illustratively, an infrared counter and a video collector can be arranged inside the feeder 2 and the water feeder 3, so as to count the eating (water intake) condition of the laboratory mouse. A temperature sensor, a humidity sensor and an ultraviolet sterilizer can be arranged inside the rearing cage 1, so that the temperature and humidity conditions of the living area of the laboratory mouse can be monitored, and the cage can be disinfected and sterilized after the laboratory mouse is moved out.

The following explains the effects of the above-described scheme:

the embodiment provides a general metabolism cage of big mouse and small mouse, can make different urine collection test tubes align with the connecting hole in the time quantum of predetermineeing through the timing rotation of collecting tray to carry out many samples collection work. Compared with the prior art, the device can save the time cost of researchers, and improve the accuracy of sample acquisition time, thereby improving the accuracy of the result of a metabolism experiment. In addition, this device can also preserve the sample through collecting the cavity to the food residue and the drinking water that leaks of laboratory mouse are retrieved. Can avoid the sample to take place to deteriorate through above-mentioned mode, prevent simultaneously that the sample from suffering the pollution of external environment, food waste or the water of leaking to avoid metabolite sample composition to change, further promote the accuracy of experimental result.

The above description is only a preferred embodiment of the present invention, and should not be taken as limiting the invention, and any modifications, equivalent replacements, improvements, etc. made within the spirit and principle of the present invention should be included in the protection scope of the present invention.

Claims (10)

1. A general metabolism cage for big and small mice, which is characterized by comprising:

a feeding assembly comprising: the feeding device comprises a feeding cage (1), a feeder (2) and a water feeder (3), wherein a bearing net (11) is arranged at the bottom of the feeding cage (1), and the feeder (2) and the water feeder (3) are detachably arranged on the side wall of the feeding cage (1);

the excrement-urine separator is arranged at the bottom of the rearing cage (1), and a urine conduit (45) and an excrement collecting barrel (44) are arranged at the bottom of the excrement-urine separator;

the collecting unit comprises a storage box (5) and a collecting assembly, wherein the storage box (5) is arranged below the excrement separator, a partition plate (51) is arranged inside the storage box, a collecting cavity (52) is formed above the partition plate (51), and an equipment cavity (53) is formed below the partition plate; a connecting hole (54) is arranged on the top surface of the storage box (5), and the urine guide pipe (45) is communicated with the connecting hole (54); the collection assembly comprises a collection tray (6) and a controller (62), the collection tray (6) is arranged inside the collection cavity (52), and a plurality of urine collection test tubes (61) which are arranged in a ring shape are arranged on the collection tray (6); the controller (62) is arranged inside the equipment cavity (53), and the collection tray (6) is driven to rotate by the controller (62) so that different urine collection test tubes (61) are aligned with the connecting holes (54) in a preset time period.

2. The universal metabolic cage for big and small mice according to claim 1, wherein: the metabolism cage comprises an isolation assembly, the isolation assembly is arranged inside the feeding cage (1) and comprises a middle shaft (12) and two isolation plates (13), the two isolation plates (13) are hinged with the side wall of the middle shaft, and a feeding area is formed between the two isolation plates (13); the feeding area is opposite to the urine guide pipe (45), and the feeder (2) and the water feeder (3) are communicated with the feeding area.

3. The universal metabolic cage for big and small mice according to claim 2, wherein: the isolation assembly comprises a fixing piece (15) and a supporting plate (14), the fixing piece (15) is arranged at the top of the isolation plate (13), a plurality of fixing holes (151) are formed in the fixing piece (15), and the fixing holes (151) are annularly arranged on the periphery of a central shaft; the supporting plate (14) is arranged outside the feeding area, and one side of the supporting plate (14) is hinged with the side wall of the central shaft; the top surface of the isolation plate (13) is provided with a first fixing protrusion (131), the top surface of the supporting plate (14) is provided with a second fixing protrusion (141), and the first fixing protrusion (131) and the second fixing protrusion (141) are inserted into the fixing holes (151).

4. The universal metabolic cage for big and small mice according to claim 1, wherein: the feeder (2) comprises: feed casing (21), hold groove (22) and feed box, be equipped with first interception net (211) on the bottom surface of feeding casing (21), hold groove (22) and slide the setting in the bottom of feeding casing (21), and hold the top surface in first interception net (211) of holding groove (22), the feed box slides and sets up inside feeding casing (21), and is equipped with the laboratory mouse fodder in the feed box.

5. The universal metabolic cage for rats and mice according to claim 4, wherein: the feed box comprises a second intercepting net, and a recovery groove (23) and a feed groove (24) which are arranged in a stepped manner, wherein the feed groove (24) is positioned above the recovery groove (23), and a feed outlet is formed in the side wall, close to the recovery groove (23), of the feed groove (24); the second intercepting net comprises a horizontal section (251) and an inclined section (252), the horizontal section (251) is arranged on the top surface of the recovery tank (23), the horizontal section (251) is located below the first intercepting net (211), the inclined section (252) is arranged inside the feed outlet, and the top of the inclined section (252) inclines towards the direction of the feed tank (24).

6. The universal metabolic cage for big and small mice according to claim 1, wherein: the water feeder (3) comprises: the water feeding device comprises a water feeding shell (31), a containing support (32), a water feeding bottle (33) and a recovery assembly, wherein the containing support (32) is arranged on the side wall of the water feeding shell (31), the water feeding bottle (33) is installed inside the containing support (32), and a bottle mouth (331) of the water feeding bottle (33) is inserted into the water feeding shell (31); retrieve the subassembly and set up in the below of feeding water casing (31), be equipped with on the bottom surface of feeding water casing (31) and retrieve the incision, retrieve the inside third interception net (311) that is equipped with of incision, and retrieve the subassembly and be linked together through retrieving incision and feeding water casing (31).

7. The universal metabolic cage for big and small mice according to claim 6, wherein: the recycling assembly comprises a flow guide channel (34) and a recycling bottle (36), the flow guide channel (34) is arranged at the bottom of the water feeding shell (31), and the flow guide channel (34) is communicated with the water feeding shell (31) through a recycling notch; the bottom surface of the flow guide channel (34) is provided with a flow guide nozzle (341), and the recovery bottle (36) is detachably arranged on the flow guide nozzle (341).

8. The universal metabolic cage for big and small mice according to claim 1, wherein: the manure separator comprises: the excrement collecting device comprises an outer cylinder body (41), an inner cylinder body and a separating cone (43), wherein the outer cylinder body (41) is sleeved outside the inner cylinder body, and an excrement collecting cylinder (44) and a urine guide pipe (45) are arranged on the bottom surface of the outer cylinder body (41);

the inner cylinder body comprises a collecting funnel (421) and a flow guide funnel (422), the large end of the collecting funnel (421) faces upwards, the large end of the flow guide funnel (422) faces downwards, and the small end of the collecting funnel (421) is communicated with the small end of the flow guide funnel (422); a flow guide groove (423) is formed in the inner wall of the large end of the flow guide funnel (422), and an included angle is formed between the flow guide groove (423) and the horizontal plane; the opening end of the excrement collecting cylinder (44) is inserted into the flow guide funnel (422), and the axis of the excrement collecting cylinder (44) is coincided with the axis of the flow guide funnel (422); one end of the diversion groove (423) close to the bottom surface of the outer cylinder body (41) is provided with a connector (424), and the connector (424) is communicated with the urine guide pipe (45);

the separation cone (43) is arranged in the collection funnel (421) with a downward opening, and the outer diameter of the opening side of the separation cone (43) is larger than the inner diameter of the small end of the collection funnel (421) and smaller than the inner diameter of the large end of the collection funnel (421).

9. The universal metabolic cage for big and small mice according to claim 1, wherein: the separating plate (51) is provided with an installation cutting groove, a semiconductor refrigerator (7) is arranged in the installation cutting groove, the cold end of the semiconductor refrigerator (7) is arranged in the collection cavity (52), the hot end of the semiconductor refrigerator is arranged in the equipment cavity (53), and the hot end of the semiconductor refrigerator (7) is provided with a radiator (71).

10. The universal metabolic cage for big and small mice according to claim 1, wherein: the metabolism cage comprises an assembling component, the assembling component comprises an upper support frame (81) and a lower support frame (82), and the upper support frame (81) is detachably arranged at the top of the lower support frame (82); the rearing cage (1) and the excrement-urine separator are arranged on an upper support frame (81), and the preservation box (5) is arranged on a lower support frame (82).

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