CN214512784U - Acetic anhydride toluene evaporation device for acyclovir intermediate preparation - Google Patents
Acetic anhydride toluene evaporation device for acyclovir intermediate preparation Download PDFInfo
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- CN214512784U CN214512784U CN202023323974.3U CN202023323974U CN214512784U CN 214512784 U CN214512784 U CN 214512784U CN 202023323974 U CN202023323974 U CN 202023323974U CN 214512784 U CN214512784 U CN 214512784U
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- tower body
- acyclovir
- acetic anhydride
- evaporation device
- toluene evaporation
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Abstract
The utility model provides an acetic anhydride toluene evaporation plant for preparation of acyclovir midbody. An acetic anhydride toluene evaporation device for preparing an acyclovir intermediate, comprising: a tower body; the plurality of L-shaped plates are fixedly arranged on the inner wall of the tower body in a staggered manner; the first temperature controller is mounted at the top in the tower body, and the second temperature controller is mounted at the bottom in the tower body; the liquid accumulation pool is arranged at the bottom in the tower body. The utility model provides an acetic anhydride toluene evaporation plant for preparation of acyclovir midbody is through setting up a plurality of L shaped plates and a plurality of impeller for the evaporation effect of crude is better, makes the efficiency of evaporation higher, and the rectification that has improved the crude to a certain extent is through setting up a plurality of L shaped plates and a plurality of impeller, makes the evaporation effect of crude better, makes the efficiency of evaporation higher, has improved the rectification of crude to a certain extent.
Description
Technical Field
The utility model relates to an acetic anhydride toluene rectifying column technical field especially relates to an acetic anhydride toluene evaporation plant for preparation of acyclovir midbody.
Background
In the preparation process of the acyclovir side chain, the collected 1, 3-dioxygen pentacyclic is transferred to a pentacyclic head tank of a side chain reaction kettle for standby by a pump in advance. Pumping 620kg of acetic anhydride into a 3000L side chain reaction kettle, then adding 5kg of p-toluenesulfonic acid (catalyst) through a charging opening, controlling the temperature after the material is completely added, slowly dropwise adding 1, 3-dioxolane, after the dropwise adding is completely finished, carrying out heat preservation reaction, transferring side chain reaction liquid into a 3000L side chain crude distillation kettle, controlling the temperature below 100 ℃, carrying out reduced pressure distillation to recover crude pre-distillation boiling (acetic acid, the boiling point of the acetic anhydride is lower than that of acyclovir side chain), collecting acetic anhydride and acetic acid steam through a 2-stage condenser (ice salt, the temperature is lower than or equal to-15 ℃) and transferring into a crude pre-distillation boiling receiving tank, collecting a small amount of steam through a 2-stage condenser (ice salt, the temperature is lower than or equal to-15 ℃), treating a trace amount of non-condensable gas G2-26 (acetic acid, acetic anhydride) through a 3 workshop tail gas absorption system, transferring the crude pre-distillation into a bibird mother liquor recovery kettle to carry out distillation to recover acetic anhydride, pumping the obtained side chain crude product into a side chain rectifying tower to carry out rectification, in the rectification process, the efficiency of evaporation is not high, so that the rectification effect is not good.
Therefore, it is necessary to provide an acetic anhydride toluene evaporation device for preparing acyclovir intermediates to solve the above technical problems.
SUMMERY OF THE UTILITY MODEL
The utility model provides a technical problem provide an acetic anhydride toluene evaporation plant for preparation of acyclovir midbody.
In order to solve the technical problem, the utility model provides an acetic anhydride toluene evaporation plant for preparation of acyclovir midbody, include: a tower body; the plurality of L-shaped plates are fixedly arranged on the inner wall of the tower body in a staggered manner; the first temperature controller is mounted at the top in the tower body, and the second temperature controller is mounted at the bottom in the tower body; the liquid accumulation tank is arranged at the bottom in the tower body; and the liquid inlet pipe is fixedly arranged in the middle of the tower body.
Preferably, the L-shaped plate is obliquely disposed in the tower body.
Preferably, rotate on the L shaped plate and install two first dwangs, two equal fixed mounting has the impeller on the first dwang, two first dwang all runs through the L shaped plate, the below of L shaped plate is equipped with the second dwang, the second dwang rotates and installs on the body of the tower, fixed mounting has two first bevel gear on the second dwang, two the equal fixed mounting in bottom of first dwang has second bevel gear, first bevel gear with second bevel gear meshes mutually, the one end of second dwang extends to outside the body of the tower, one side fixed mounting of body of the tower has the motor, the output shaft of motor with the one end fixed connection of second dwang.
Preferably, a bearing hole is formed in one side of the tower body, a sealing bearing is fixedly mounted in the bearing hole, and the second rotating rod is fixedly connected with an inner ring of the sealing bearing.
Preferably, one side of the L-shaped plate is provided with a plurality of liquid outlet holes.
Preferably, the bottom of the liquid accumulation pool is provided with a liquid outlet pipe.
Preferably, the top of the tower body is provided with an evacuation pipe.
Preferably, an air outlet pipe is arranged on one side of the top of the tower body.
Compared with the prior art, the utility model provides an acetic anhydride toluene evaporation plant for preparation of acyclovir midbody has following beneficial effect:
the utility model provides an acetic anhydride toluene evaporation plant for preparation of acyclovir midbody through setting up a plurality of L shaped plates and a plurality of impeller for the evaporation effect of crude is better, makes the efficiency of evaporation higher, has improved the rectification of crude to a certain extent.
Drawings
Fig. 1 is a schematic cross-sectional structural diagram of an acetic anhydride toluene evaporation device for preparing an acyclovir intermediate provided by the present invention;
fig. 2 is an enlarged view of a portion a in fig. 1.
Reference numbers in the figures: 1. the tower body, 2, L shaped plate, 3, first thermostat, 4, second thermostat, 5, hydrops pond, 6, feed liquor pipe, 7, drain pipe, 8, evacuation pipe, 9, outlet duct, 10, first dwang, 11, impeller, 12, second dwang, 13, first conical gear, 14, motor, 15, play liquid hole, 16, second conical gear.
Detailed Description
The present invention will be further described with reference to the accompanying drawings and embodiments.
Referring to fig. 1-2, in an embodiment of the present invention, an acetic anhydride toluene evaporation apparatus for acyclovir intermediate preparation includes: a tower body 1; the plurality of L-shaped plates 2 are fixedly installed on the inner wall of the tower body 1 in a staggered mode; the temperature control device comprises a first temperature controller 3 and a second temperature controller 4, wherein the first temperature controller 3 is installed at the top in the tower body 1, and the second temperature controller 4 is installed at the bottom in the tower body 1; the liquid accumulation tank 5 is mounted at the bottom in the tower body 1; and the liquid inlet pipe 6 is fixedly arranged in the middle of the tower body 1.
The L-shaped plate 2 is obliquely arranged in the tower body 1.
Rotate on the L shaped plate 2 and install two first dwang 10, two equal fixed mounting has impeller 11, two on the first dwang 10 all runs through L shaped plate 2, the below of L shaped plate 2 is equipped with second dwang 12, second dwang 12 rotates and installs on the body of the tower 1, fixed mounting has two first bevel gear 13 on the second dwang 12, two the equal fixed mounting in bottom of first dwang 10 has second bevel gear 16, first bevel gear 13 with second bevel gear 16 meshes mutually, the one end of second dwang 12 extends to outside the body of the tower 1, one side fixed mounting of body of the tower 1 has motor 14, motor 14 the output shaft with the one end fixed connection of second dwang 12.
A bearing hole is formed in one side of the tower body 1, a sealing bearing is fixedly mounted in the bearing hole, and the second rotating rod 12 is fixedly connected with an inner ring of the sealing bearing.
A plurality of liquid outlet holes 15 are formed in one side of the L-shaped plate 2.
And a liquid outlet pipe 7 is arranged at the bottom of the liquid accumulation pool 5.
An evacuating pipe 8 is arranged at the top of the tower body 1.
And an air outlet pipe 9 is arranged on one side of the top of the tower body 1.
The utility model provides an acetic anhydride toluene evaporation plant for preparation of acyclovir midbody's theory of operation as follows:
a vacuum-pumping pipe 8 is connected with a vacuum-pumping machine, when rectification is needed, firstly, a tower body 1 is vacuumized, meanwhile, the temperatures of a first temperature controller 3 and a second temperature controller 4 are respectively adjusted, so that the temperatures of the tower top and the tower bottom are different, the obtained side chain crude product is pumped into the tower body 1 through a liquid inlet pipe 6, at the moment, the crude product flows onto a corresponding L-shaped plate 2, a motor 14 is started, the motor 14 drives a second rotating rod 12 to rotate, the second rotating rod 12 rotates to drive a first bevel gear 13 to rotate, the first bevel gear 13 rotates to drive a second bevel gear 16 to rotate, the second bevel gear 16 rotates to drive a first rotating rod 10 to rotate, the first rotating rod 10 rotates to drive a impeller 11 to rotate, so that the crude product is stirred, the evaporation efficiency is higher, meanwhile, the crude product flows onto the next L-shaped plate 2 through a plurality of liquid outlet holes 15 until the crude product flows into a liquid accumulating pool 5, and after the crude product passes through a plurality of L-shaped plates 2, and some substances are evaporated under the heating action of the second temperature controller 4, when the evaporated substances move upwards and contact with the first temperature controller 3, a part of the evaporated substances are cooled to become liquid and drop on the corresponding L-shaped plate 2, and the rest steam is discharged into the corresponding device through the air outlet pipe 9.
Compared with the prior art, the utility model provides an acetic anhydride toluene evaporation plant for preparation of acyclovir midbody has following beneficial effect:
this device is through setting up a plurality of L shaped plates 2 and a plurality of impeller 11 for the evaporation effect of crude is better, makes the efficiency of evaporation higher, has improved the rectification of crude to a certain extent.
The above only is the embodiment of the present invention, not limiting the scope of the present invention, all the equivalent structures or equivalent processes of the present invention are used in the specification and the attached drawings, or directly or indirectly applied to other related technical fields, and the same principle is included in the protection scope of the present invention.
Claims (8)
1. An acetic anhydride toluene evaporation device for preparing an acyclovir intermediate is characterized by comprising:
a tower body;
the plurality of L-shaped plates are fixedly arranged on the inner wall of the tower body in a staggered manner;
the first temperature controller is mounted at the top in the tower body, and the second temperature controller is mounted at the bottom in the tower body;
the liquid accumulation tank is arranged at the bottom in the tower body;
and the liquid inlet pipe is fixedly arranged in the middle of the tower body.
2. The acetic anhydride toluene evaporation apparatus for acyclovir intermediate preparation, according to claim 1, wherein the L-shaped plate is disposed in the tower body in an inclined manner.
3. The acetic anhydride toluene evaporation device for acyclovir intermediate preparation according to claim 1, wherein two first rotating rods are rotatably mounted on the L-shaped plate, two impellers are fixedly mounted on the first rotating rods, the two first rotating rods penetrate through the L-shaped plate, a second rotating rod is arranged below the L-shaped plate, the second rotating rod is rotatably mounted on the tower body, two first bevel gears are fixedly mounted on the second rotating rod, two second bevel gears are fixedly mounted at the bottom ends of the first rotating rods, the first bevel gears are meshed with the second bevel gears, one end of the second rotating rod extends to the outside of the tower body, a motor is fixedly mounted on one side of the tower body, and an output shaft of the motor is fixedly connected with one end of the second rotating rod.
4. The acetic anhydride toluene evaporation device for acyclovir intermediate preparation according to claim 3, wherein a bearing hole is formed in one side of the tower body, a sealing bearing is fixedly installed in the bearing hole, and the second rotating rod is fixedly connected with an inner ring of the sealing bearing.
5. The acetic anhydride toluene evaporation device for acyclovir intermediate preparation as claimed in claim 1, wherein one side of the L-shaped plate is provided with a plurality of liquid outlet holes.
6. The acetic anhydride toluene evaporation device for acyclovir intermediate preparation, as claimed in claim 1, wherein the bottom of the liquid accumulation pool is equipped with a liquid outlet pipe.
7. The acetic anhydride toluene evaporation device for acyclovir intermediate preparation, as claimed in claim 1, wherein the top of the tower body is equipped with a vacuum tube.
8. The acetic anhydride toluene evaporation device for acyclovir intermediate preparation, as claimed in claim 1, wherein an air outlet pipe is installed at one side of the top of the tower body.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202023323974.3U CN214512784U (en) | 2020-12-31 | 2020-12-31 | Acetic anhydride toluene evaporation device for acyclovir intermediate preparation |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202023323974.3U CN214512784U (en) | 2020-12-31 | 2020-12-31 | Acetic anhydride toluene evaporation device for acyclovir intermediate preparation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN214512784U true CN214512784U (en) | 2021-10-29 |
Family
ID=78299314
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202023323974.3U Active CN214512784U (en) | 2020-12-31 | 2020-12-31 | Acetic anhydride toluene evaporation device for acyclovir intermediate preparation |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN214512784U (en) |
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2020
- 2020-12-31 CN CN202023323974.3U patent/CN214512784U/en active Active
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