CN214334970U - Multifunctional reagent detection box - Google Patents
Multifunctional reagent detection box Download PDFInfo
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- CN214334970U CN214334970U CN202022657467.7U CN202022657467U CN214334970U CN 214334970 U CN214334970 U CN 214334970U CN 202022657467 U CN202022657467 U CN 202022657467U CN 214334970 U CN214334970 U CN 214334970U
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Abstract
The utility model discloses a multi-functional reagent detects box, through urine tangible analysis part: the particle imaging area of the detection box is matched with the particle imaging chip to analyze urine visible components, and then the detection result is transmitted to a human-computer display terminal of a matched instrument; urine dry chemical analysis part: the urine dry chemical detection module of the matched instrument drives the detection head, the test paper medicine block part in the detection box is analyzed by utilizing a reflection photoelectric colorimetric method, the urine dry chemical analysis result is displayed on a human-computer interface of the matched instrument after data processing, a plurality of urine dry chemical tests can be carried out as required, the matched instrument is simple to operate, the focal length is not required to be adjusted, the classification and the quantity of visible components are not required to be manually identified, the detection box is integrated with the particle detection imaging module and the urine dry chemical detection test paper block, the urine visible component analysis and the urine dry chemical analysis can be simultaneously carried out, the urine dry chemical and the urine visible components can be detected at one time, the detection result can be obtained at one time, and the popularization of microparticle detection is facilitated.
Description
Technical Field
The utility model relates to a micro-detection and dry chemical test paper detection area of microparticle especially relates to a multi-functional reagent detects box in medical treatment inspection.
Background
At present, common detection methods for urine formed components include manual microscopic examination, quantitative counting cell type automatic urinary sediment analyzer detection, sheath flow type automatic analyzer detection, flow cytometry combined electrical impedance detection and the like.
The detection of a quantitative counting pool type urinary sediment automatic analyzer and the detection of a sheath flow type automatic analyzer are the detection modes which are used in the market at present. The detection method is the evolution of artificial microscopic examination, the urine sample is precipitated in a counting pool or forms sheath flow in a sheath flow pool by an instrument through a liquid path control technology, and then is subjected to image shooting identification after being amplified by a microscope system, so that the repeatability of a sample test result is greatly improved, the detection result is not different due to individual difference of inspectors, more importantly, the detection efficiency is improved, and the universal application of the detection of the visible components of the urine is realized. But the automatic instrument is more complicated, and the cost is higher, and is difficult to popularize in primary hospitals.
Flow cytometry combined with electrical impedance detection requires special dye solution and a precise optical detection mechanism, so that the instrument is more complex, the detection cost is higher, and the flow cytometry combined with electrical impedance detection is generally used only in three-level hospitals.
Most primary hospitals generally can only carry out dry chemical detection of urine at present, and because the instrument structure for detecting visible components of urine is complex, the detection cost is high, the detection of the visible components of urine and dry chemical test paper in primary hospitals is difficult to popularize.
SUMMERY OF THE UTILITY MODEL
An object of the utility model is to provide a multifunctional reagent detects box, the most basic unit hospital who aims at solving among the prior art generally can only carry out the dry chemistry of urine and detects, because the instrument structure that the tangible composition of urine detected is complicated, and detection cost is high to be difficult to promote and carry out the technical problem that the tangible composition of urine and the dry chemistry test paper of urine detected at basic unit hospital.
In order to achieve the above purpose, the utility model discloses a multifunctional reagent detection box, which comprises a substrate and a detection device; the substrate is provided with a sample dripping area, a sample imaging area and a sample shunting channel, the sample dripping area is positioned on one side of the substrate, an opening of the sample dripping area penetrates through the substrate, the sample imaging area is positioned on one side, close to the sample dripping area, of the substrate and is communicated with the sample dripping area, and the sample shunting channel is positioned on one side, far away from the sample imaging area, of the sample dripping area and is communicated with the sample dripping area; the detection device comprises a test paper medicine block and a detection imaging component, wherein the test paper medicine block is detachably connected with the base plate, is communicated with the sample shunting channel and is positioned on one side of the sample shunting channel, which is far away from the sample dripping area; the detection imaging assembly comprises a cover glass and a particle imaging chip, the cover glass is fixedly connected with the substrate and is positioned on one side of the substrate close to the sample imaging area, and the particle imaging chip is fixedly connected with the substrate and is positioned between the substrate and the cover glass.
The substrate is also provided with a sample excessive storage area, and the sample excessive storage area is communicated with the sample imaging area and is positioned on one side of the sample imaging area, which is far away from the sample dripping area.
The substrate is also provided with a data transmission interface, the data transmission interface is connected with the particle imaging chip of the sample imaging area through a cable and is positioned on one side of the substrate close to the sample excess storage area.
The substrate is further provided with a power interface, the power interface is connected with the particle imaging chip through a cable, and the power interface is located on one side, close to the data transmission interface, of the substrate.
The base plate is provided with a medicine block storage groove, and the medicine block storage groove is located on one side, close to the test paper medicine block, of the base plate and matched with the test paper medicine block.
The utility model discloses a multi-functional reagent detects box, through urine tangible analysis part: the particle imaging area of the detection box is matched with the particle imaging chip to analyze urine visible components, and then the detection result is transmitted to a human-computer display terminal of a matched instrument; urine dry chemical analysis part: the urine dry chemical detection module of the matched instrument drives the detection head, the test paper medicine block part in the detection box is analyzed by utilizing a reflection photoelectric colorimetric method, the urine dry chemical analysis result is displayed on a human-computer interface of the matched instrument after data processing, a plurality of urine dry chemical tests can be carried out as required, the matched instrument is simple to operate, the focal length is not required to be adjusted, the classification and the quantity of visible components are not required to be manually identified, the detection box is integrated with the particle detection imaging module and the urine dry chemical detection test paper block, the urine visible component analysis and the urine dry chemical analysis can be simultaneously carried out, the urine dry chemical and the urine visible components can be detected at one time, the detection result can be obtained at one time, and the popularization of microparticle detection is facilitated.
Drawings
In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings used in the description of the embodiments or the prior art will be briefly described below, it is obvious that the drawings in the following description are only some embodiments of the present invention, and for those skilled in the art, other drawings can be obtained according to these drawings without creative efforts.
Fig. 1 is a schematic view of the internal structure of the substrate of the present invention.
Fig. 2 is a cross-sectional view a-a of the substrate of fig. 1 according to the present invention.
Fig. 3 is an enlarged view of the point I in fig. 2 according to the present invention.
In the figure: 1-substrate, 2-detection device, 11-sample dripping area, 12-sample imaging area, 13-sample shunting channel, 14-sample excess storage area, 15-data transmission interface, 16-power interface, 17-medicine block storage tank, 21-test paper medicine block, 22-detection imaging component, 100-multifunctional reagent detection box, 221-cover glass and 222-particle imaging chip.
Detailed Description
Reference will now be made in detail to embodiments of the present invention, examples of which are illustrated in the accompanying drawings, wherein like reference numerals refer to the same or similar elements or elements having the same or similar function throughout. The embodiments described below with reference to the drawings are exemplary and intended to be used for explaining the present invention, and should not be construed as limiting the present invention.
In the description of the present invention, it is to be understood that the terms "length", "width", "upper", "lower", "front", "rear", "left", "right", "vertical", "horizontal", "top", "bottom", "inner", "outer", and the like indicate orientations or positional relationships based on those shown in the drawings, and are merely for convenience of description and simplicity of description, and do not indicate or imply that the device or element being referred to must have a particular orientation, be constructed and operated in a particular orientation, and thus, should not be construed as limiting the present invention. In addition, in the description of the present invention, "a plurality" means two or more unless specifically limited otherwise.
Referring to fig. 1 to 3, the present invention provides a multifunctional reagent detecting box 100, which includes a substrate 1 and a detecting device 2; the substrate 1 is provided with a sample dripping area 11, a sample imaging area 12 and a sample diversion channel 13, the sample dripping area 11 is positioned on one side of the substrate 1, an opening of the sample dripping area penetrates through the substrate 1, the sample imaging area 12 is positioned on one side, close to the sample dripping area 11, of the substrate 1 and is communicated with the sample dripping area 11, and the sample diversion channel 13 is positioned on one side, far away from the sample imaging area 12, of the sample dripping area 11 and is communicated with the sample dripping area 11; the detection device 2 comprises a test paper medicine block 21 and a detection imaging component 22, wherein the test paper medicine block 21 is detachably connected with the substrate 1, is communicated with the sample shunting channel 13 and is positioned on one side of the sample shunting channel 13, which is far away from the sample dripping area 11; the detection imaging assembly 22 comprises a cover glass 221 and a particle imaging chip 222, wherein the cover glass 221 is fixedly connected with the substrate 1 and is positioned on one side of the substrate 1 close to the sample imaging area 12, and the particle imaging chip 222 is fixedly connected with the substrate 1 and is positioned between the substrate 1 and the cover glass 221.
In this embodiment, the urine formed component analysis and detection portion is implemented by a detection box, and specifically, the substrate 1 of the detection box is generally made of glass or other transparent materials, so as to facilitate observation of the condition that the sample fills the imaging area after dropping the sample, and facilitate illumination of the instrument light source, so that the imaging effect is clearer. The sample dripping area 11 and the sample imaging area 12 are designed on the detection box substrate 1, the particle imaging chip 222 and the cover glass 221 are attached, and the sample dripping area 11 and the sample imaging area 12 are communicated with each other; the sample imaging area 12 is a cavity with equal thickness formed between the box substrate 1 and the cover glass 221, the particle imaging chip 222 is adhered below the sample imaging area 12, the particle imaging chip 222 can adopt a semi-floating gate transistor or a composite dielectric gate photosensitive detector as a photosensitive imaging unit, and the size of a single photosensitive pixel unit is less than or equal to 0.5 μm. The size of the micro-particles in urine and blood is generally more than 5 μm, and the pixel is enough to obtain clear particle shape information; the micro-particles in the sample are fully precipitated in the imaging area under the action of gravity and are basically attached to the bottom of the imaging area finally; the supporting instrument controls the particle imaging chip 222 to record information such as the form and quantity of the visible components; the volume of the detected sample can be calculated by calculating the area of the imaging area of the chip and the thickness of the sample imaging area 12, and further, the accurate information of each micro-particle in the detected sample can be accurately calculated according to the information such as the shape, the number and the like of the micro-particles obtained by the chip; the imaging area size of the particle imaging chip 222 varies according to different inspection accuracy; during testing, a liquid transfer gun, a capillary tube or other liquid transfer devices can be used for dropping a sample into the sample dropping area 11, the sample in the sample dropping area 11 enters the sample imaging area 12 along a flow channel until the sample imaging area 12 is filled, the urine sample does not need to be centrifuged, the sample dropping operation is simple, and the operation can be completed by ordinary personnel; then, the detection box with the sample is put into a matched instrument, and the sample is fully precipitated in the sample imaging area 12, so that the accurate information of the sample detected by the particle imaging chip 222 can be ensured; at this time, the supporting instrument controls the particle imaging chip 222 through the data transmission interface 15; the urine dry chemical analysis and detection part is implemented by matched instruments, specifically, a cold light source irradiation receiving detection head is arranged in each matched instrument, during testing, several different wavelengths of light are emitted to irradiate and emit colors to react on the test paper medicine block 21, and corresponding urine dry chemical information detection results such as urine cholangiogen, bilirubin, ketone bodies, nitrite, red blood cells, leukocyte esterase, specific gravity, pH value, protein, microalbumin, glucose, ascorbic acid, creatinine, calcium, urine color and the like are obtained after the received photoelectric signal data are processed by a central processing unit algorithm; during testing, a liquid transfer gun, a capillary tube or other liquid transfer devices can be used for dropping a sample into the sample dropping area 11 or directly dropping the sample onto the test paper block 21, and the sample in the sample dropping area 11 enters the test paper block 21 along the sample diversion channel 13 until the test paper block 21 is effectively soaked; then the multifunctional reagent detection box 100 with the sample dripped is put into a matched instrument, and after the sample fully reacts in the test paper drug block 21, the accurate information of the detected sample can be ensured; at the moment, the supporting instrument transmits the photoelectric emission information of the test paper drug block 21 to an information processing unit of the supporting instrument for processing and calculation through a detection head, and finally, a urine dryness chemical detection result is obtained; wherein the urine tangible analysis part: the particle imaging area of the detection box is matched with the particle imaging chip 222 to analyze urine visible components, and then the detection result is transmitted to a human-computer display terminal of a matched instrument; urine dry chemical analysis part: the urine dry chemical detection module of the supporting instrument drives the detection head, the reflection photoelectric colorimetry is used for analyzing the test paper medicine block 21 in the detection box, the urine dry chemical analysis result is displayed on a human-computer interface of the supporting instrument after data processing, 10, 11 or 14 urine dry chemical tests can be carried out according to requirements, the multifunctional reagent detection box 100 integrates the microparticle detection technology and dry chemical test paper detection, can quickly, simply and accurately detect the information such as the form and the quantity of microparticles in a sample, specifically uses the method including but not limited to urine visible component microscopic detection, blood cell morphological detection and other body fluid microscopic detection, and can quickly, simply and accurately detect the information such as the form and the quantity of the microparticles in the sample and urobilinogen, bilirubin, ketone bodies, nitrite, red blood cells, leukocyte esterase, specific gravity, pH value, and the like, The urine dryness chemical information such as protein, microalbumin, glucose, ascorbic acid, creatinine, calcium, urine color and the like, and the matching instrument has simple operation, does not need to adjust focal length, manually identify the classification and the quantity of visible components, has good repeatability of the test result, does not generate different test results due to individual difference of testers, and can finish the test by common personnel according to the instruction prompt to obtain an accurate test result; the detection box integrates the particle detection imaging module and the urine dry chemical detection test paper block, can simultaneously perform urine visible component analysis and urine dry chemical analysis, can detect urine dry chemistry and urine visible components at one time, and can output a detection result at one time, the detection is convenient and quick, and the detection box is low in cost, can be used as a disposable consumable, is disposable, has no cross contamination in continuous sample detection, and is small in size, free of reagents, free of a liquid path mechanism, a microscope system and a photographing system in the instrument, short in test time, simple in structure, convenient to use, low in maintenance cost and low in instrument price, and all primary hospitals even including general families with detection requirements can purchase the instrument, so that the popularization of microparticle detection is facilitated.
Further, referring to fig. 1, the substrate 1 further has a sample excess storage region 14, and the sample excess storage region 14 is connected to the sample imaging region 12 and is located on a side of the sample imaging region 12 away from the sample dripping region 11.
In this embodiment, the sample drips the appearance and carries out the urine and drips appearance in the appearance district 11, and the sample gets into sample imaging area 12, because the urine sample is in the sample drips the appearance and lasts dripping in the appearance district 11, sample imaging area 12 can't continue to save the urine sample to make the urine sample flow in with sample drips the appearance district 11 and link up the excessive storage area 14 of sample is saved, so use more convenient.
Further, referring to fig. 1, the substrate 1 further has a data transmission interface 15, and the data transmission interface 15 is connected to the particle imaging chip 222 of the sample imaging area 12 through a cable and is located on a side of the substrate 1 close to the sample excess storage area 14.
In this embodiment, the imaging information obtained on the particle imaging chip 222 is transmitted to the information processing unit of the associated instrument through the data transmission interface 15 for processing and calculation, and finally the detection result is obtained, the particle imaging area of the detection box is used for analyzing urine visible components in cooperation with the particle imaging chip 222, and then the detection result is transmitted to the human-computer display terminal of the associated instrument through the data transmission interface of the detection box, so that the detection is more convenient.
Further, referring to fig. 1, the substrate 1 further has a power interface 16, the power interface 16 is connected to the particle imaging chip 222 through a cable, and the power interface 16 is located on a side of the substrate 1 close to the data transmission interface 15.
Further, referring to fig. 1, the substrate 1 further has a medicine block storage slot 17, and the medicine block storage slot 17 is located on one side of the substrate 1 close to the test paper medicine block and is matched with the test paper medicine block.
In this embodiment, the number of the tablet storage slots 17 may be multiple, each tablet storage slot 17 is communicated with one of the sample diversion channels 13, and one test paper tablet 21 is stored in an inner shell of each tablet storage slot 17, so that a plurality of test paper tablets 21 can be placed for one-time detection, and the detection is more convenient.
While the invention has been described with reference to a preferred embodiment, it will be understood by those skilled in the art that various changes in form and details may be made therein without departing from the spirit and scope of the invention.
Claims (5)
1. A multifunctional reagent detection box is characterized by comprising a substrate and a detection device;
the substrate is provided with a sample dripping area, a sample imaging area and a sample shunting channel, the sample dripping area is positioned on one side of the substrate, an opening of the sample dripping area penetrates through the substrate, the sample imaging area is positioned on one side, close to the sample dripping area, of the substrate and is communicated with the sample dripping area, and the sample shunting channel is positioned on one side, far away from the sample imaging area, of the sample dripping area and is communicated with the sample dripping area;
the detection device comprises a test paper medicine block and a detection imaging component, wherein the test paper medicine block is detachably connected with the base plate, is communicated with the sample shunting channel and is positioned on one side of the sample shunting channel, which is far away from the sample dripping area;
the detection imaging assembly comprises a cover glass and a particle imaging chip, the cover glass is fixedly connected with the substrate and is positioned on one side of the substrate close to the sample imaging area, and the particle imaging chip is fixedly connected with the substrate and is positioned between the substrate and the cover glass.
2. The multifunctional reagent cartridge according to claim 1,
the substrate is also provided with a sample excessive storage area which is communicated with the sample imaging area and is positioned on one side of the sample imaging area far away from the sample dripping area.
3. The multifunctional reagent cartridge according to claim 2,
the substrate is also provided with a data transmission interface, and the data transmission interface is connected with the particle imaging chip of the sample imaging area (12) through a cable and is positioned on one side of the substrate close to the sample excess storage area.
4. The multifunctional reagent cartridge according to claim 3,
the substrate is also provided with a power interface, the power interface is connected with the particle imaging chip through a cable, and the power interface is positioned on one side of the substrate close to the data transmission interface.
5. The multifunctional reagent cartridge according to claim 1,
the base plate is also provided with a medicine block storage groove, and the medicine block storage groove is positioned on one side of the base plate close to the test paper medicine block and matched with the test paper medicine block.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202022657467.7U CN214334970U (en) | 2020-11-17 | 2020-11-17 | Multifunctional reagent detection box |
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| Application Number | Priority Date | Filing Date | Title |
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| CN202022657467.7U CN214334970U (en) | 2020-11-17 | 2020-11-17 | Multifunctional reagent detection box |
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| CN214334970U true CN214334970U (en) | 2021-10-01 |
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| CN202022657467.7U Active CN214334970U (en) | 2020-11-17 | 2020-11-17 | Multifunctional reagent detection box |
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