CN214303073U

CN214303073U - Container formula removes nucleic acid testing biology laboratory

Info

Publication number: CN214303073U
Application number: CN202023028344.3U
Authority: CN
Inventors: 韩宗润
Original assignee: Guangzhou Forever Purification Equipment Installation Engineering Co ltd
Current assignee: Guangzhou Forever Purification Equipment Installation Engineering Co ltd
Priority date: 2020-12-16
Filing date: 2020-12-16
Publication date: 2021-09-28
Anticipated expiration: 2030-12-16

Abstract

The utility model provides a container type mobile nucleic acid detection biological laboratory, which comprises a cabin body, an environment monitoring system, a ventilation system, a water utilization system and a control system, wherein the environment monitoring system, the ventilation system, the water utilization system and the control system are arranged in the cabin body; a PCR corridor is arranged in the cabin body, a reagent preparation area and an equipment room are respectively arranged at two ends of the PCR corridor, and a sample preparation area, an amplification analysis area and a washing and sterilizing area are sequentially arranged between the reagent preparation area and the equipment room; the environment monitoring system monitors the temperature, the humidity and the pressure in the cabin body in real time and adjusts the pressure; the ventilation system is a negative pressure type fresh air system, so that a negative pressure state is formed in the cabin body; and the control system is connected with the environment monitoring system and is used for man-machine interaction and data storage. The utility model discloses the container design, equipment flexibility is high, and each operation interval is independent and continuous, and the continuity and the cross contamination risk of guaranteeing the operation are little, can guarantee the accuracy of testing result.

Description

Container formula removes nucleic acid testing biology laboratory

Technical Field

The utility model relates to a medical treatment laboratory field, more specifically relate to a container formula removes nucleic acid and detects biological laboratory.

Background

Pneumonia caused by 2019-nCoV spreads globally at the end of 2019, so that medical staff, medical equipment, medical sites and other medical resources are extremely short, and the situation of serious shortage is caused all over the world.

In the active epidemic prevention and control work, the determination of infected patients is a crucial part, and nucleic acid detection is a main means for judging whether a human body is infected with viruses, but in the daily medical facilities for acute infectious disease nucleic acid detection are large-scale infectious disease special hospitals, and in areas where medical materials are limited or in short supply, such as remote areas, the requirements of nucleic acid detection cannot be met rapidly and flexibly in large quantities, so that a mobile nucleic acid detection biological laboratory with high integration level is required to be designed.

SUMMERY OF THE UTILITY MODEL

An object of the utility model is to provide a container formula removes nucleic acid testing biological laboratory, its integrated level is high and portable, solves the area that lacks medical equipment remote area and a large amount of medical equipment demands among the prior art, can not in time carry out infectious disease nucleic acid testing's technical problem.

In order to achieve the above object, the utility model provides a container type mobile nucleic acid detection biological laboratory, which comprises a chamber body, an environment monitoring system, a ventilation system, a water using system and a control system, wherein the environment monitoring system, the ventilation system, the water using system and the control system are arranged in the chamber body; a PCR corridor is arranged in the cabin body, a reagent preparation area and an equipment room are respectively arranged at two ends of the PCR corridor, and a sample preparation area, an amplification analysis area and a washing and sterilizing area are sequentially arranged between the reagent preparation area and the equipment room; the environment monitoring system comprises a temperature subsystem, a humidity subsystem and a pressure regulating subsystem, and is used for monitoring and regulating the temperature, the humidity and the pressure in the cabin body in real time respectively; the ventilation system is a negative pressure type ventilation system, one end of the ventilation system is connected with the external environment, the other end of the ventilation system is connected with a main air inlet, the reagent preparation area, the sample preparation area, the amplification analysis area and the washing and sterilization area are respectively provided with an air outlet and an air inlet, and the main air inlet is connected with each air outlet; and the control system is connected with the environment monitoring system and is used for man-machine interaction and data storage.

Preferably, the total air inlet and each air inlet are respectively provided with a primary filter, a medium-efficiency filter and a high-efficiency filter, and the air cleanliness of the inlet air and the exhaust air reaches level c.

Further preferably, the PCR corridor is connected to three buffer rooms, and the three buffer rooms are respectively connected to the reagent preparation area, the sample preparation area, the amplification and analysis area, and the wash and kill bacteria area.

Preferably, a combined water tank and a combined top tank are arranged in the buffer room, the combined water tank comprises shoe lattices, and the combined top tank comprises clothes lattices.

Further preferably, an ultraviolet disinfection system and a disinfectant atomization disinfection system are arranged in the buffer room.

Further preferably, the reagent preparation area, the sample preparation area, the amplification analysis area and the decontamination and sterilization area are all provided with a transmission window.

Further preferably, the water using system and the ventilation system are arranged in the equipment room, the equipment room is an independent space, and one side of the equipment room, which is far away from the PCR corridor, is communicated with the outside.

Preferably, the pressure adjustment subsystem includes a plurality of pressure sensors and a plurality of pressure valves, each pressure valve is respectively disposed at each air inlet and is configured to control an air inlet flow rate of the air inlet, each pressure sensor and each pressure valve are connected to the control system, and the control system receives pressure detection information transmitted by the pressure sensor and controls the pressure valve to adjust the air inlet flow rate of the air inlet.

The utility model discloses the beneficial effect who has as follows:

1) the utility model provides a container formula removes nucleic acid testing biological laboratory with reagent preparation district, sample preparation district, amplification analysis district and decontamination sterilization district independent nevertheless the integrated setting of intercommunication in proper order in the container, the integrated level is high, each district operates in succession and the cross contamination risk is little. The container type design enables the laboratory to be movable, can reach regions with requirements quickly and flexibly, and is high in flexibility and strong in practicability. The temperature, the humidity and the pressure in the container body are monitored in real time, real-time monitoring data are displayed in real time, the environment in the container body is conveniently monitored in real time, the pressure in the container body is adjusted through the pressure adjusting subsystem, and the pressure in the container body is ensured to be in a negative pressure state, so that a pressure difference is formed between the inside and the outside of the container body, and the air in the container body is not easy to flow out of the container body to pollute the external environment. Meanwhile, aerosol is prevented from being polluted mutually, and the accuracy of a detection result is ensured.

2) The ventilation system is connected with the primary filter, the intermediate filter and the high-efficiency filter, the air cleanliness reaches the level c, the exhaust and air intake cleanliness is guaranteed, and the cross contamination between the cabin body and the external environment through air is prevented.

3) The ultraviolet disinfection device is provided with a buffer room, an ultraviolet disinfection system and a disinfectant atomization disinfection system are arranged in the buffer room, so that cross contamination of people and objects between the intervals is avoided, human bodies are sterilized and disinfected in time, and the human bodies are prevented from being harmed by viruses or microorganisms.

Drawings

FIG. 1 is a schematic view of the planar structure layout of the present invention

Reference numerals:

1. a PCR corridor; 2. a reagent preparation zone; 3. a sample preparation zone; 4. amplifying the analysis area; 5. washing the sterilization area; 6. a device room; 7. a ventilation system; 8. a water use system; 91. a first buffer room; 92. a second buffer room; 93. a third buffer room; 94. a combined water tank; 95. a combined top cabinet; 10. a pass-through window; 100. A cabin body.

Detailed Description

The embodiments described below are only a part of the embodiments of the present invention, and not all of them. Based on the embodiments in the present invention, all other embodiments obtained by a person skilled in the art without creative efforts belong to the protection scope of the present invention.

The following embodiment of the present invention relates to a container-type mobile nucleic acid testing biological laboratory, and please refer to fig. 1.

A container-type mobile nucleic acid detection biological laboratory comprises a chamber 100, and an environment monitoring system, a ventilation system 7, a water using system 8 and a control system (not shown) arranged in the chamber 100.

Be equipped with a PCR corridor 1 in the cabin body 100, the both ends in PCR corridor 1 are equipped with a reagent preparation area 2 and an equipment room 6 respectively, reagent preparation area 2 extremely be equipped with a sample preparation area 3, an amplification analysis area 4 and one wash and eliminate fungus district 5 between the equipment room 6 in proper order. Reagent preparation district 2 sample preparation district 3 amplification analysis district 4 with wash and all be equipped with a pass-through box 10 between kill fungus district 5 for article transfer guarantees the continuity of operation, and article transfer is convenient and cross contamination risk is little. The equipment room 6 is an independent space, and one side of the equipment room, which is far away from the PCR corridor 1, is communicated with the outside. PCR corridor 1 intercommunication has between first buffering 91, second buffering 92 and third buffering 93, 91 between first buffering with 2 intercommunications in reagent preparation district, between the second intercommunication with 3 intercommunications in sample preparation district, the third buffering 93 with amplification analysis district 4 reaches wash sterilization district 5 intercommunication, 91 between first buffering 92 between the second buffering and all be equipped with a combination formula water tank 94 and a combination formula top cabinet 95 in the third buffering 93, combination formula water tank 94 includes the shoes check for place the shoes of changing, combination formula top cabinet 95 includes the clothing check for place the clothes of changing. The first buffer room 91, the second buffer room 92 and the third buffer room 93 are all provided with an ultraviolet disinfection system and a disinfection liquid atomization disinfection system, specifically, the ultraviolet disinfection system comprises an ultraviolet disinfection light source and an ultraviolet controller which are arranged on the walls of the first buffer room 91, the second buffer room 92 and the third buffer room 93, the ultraviolet controller can be controlled manually and remotely by the control system, the disinfection liquid atomization disinfection system comprises a disinfection liquid tank and an atomization controller which are arranged on the walls of the first buffer room 91, the second buffer room 92 and the third buffer room 93 and an atomization nozzle which is arranged on the disinfection liquid tank, the atomization controller can be controlled manually and remotely by the control system, and a worker can manually select a disinfection mode to disinfect when entering the first buffer room 91, the second buffer room 92 and the third buffer room 93, when no person is present, the control system can disinfect the environments in the first buffer room 91, the second buffer room 92 and the third buffer room 93, so that the cleanliness of people, objects and the environment is guaranteed, the people and the objects in each interval are prevented from carrying cross contamination through the people and the objects, the human body is prevented from being biologically cleaned in time, and the human body is prevented from being harmed by viruses or microorganisms.

The ventilation system 7 and the water using system 8 are arranged in the equipment room 6, and the door opening direction of the equipment room 6 faces to the side far away from the PCR corridor 1 and is communicated with the external environment. Ventilation system 7 is negative pressure formula ventilation system 7, and total air intake is connected to its one end, other end intercommunication external environment, reagent preparation district 2 sample preparation district 3 amplification analysis district 4 with wash and eliminate bacterial zone 5 and all be equipped with air outlet and air intake, total air intake connection each the air outlet, negative pressure formula new trend system will dirty gas passes through each in the cabin body 100 the air outlet is discharged, makes form the negative pressure in the cabin body 100, and the external air process the air intake gets into in the cabin body 100, form the circulation of air, makes the air in the cabin body 100 is difficult to flow the container external and pollute external environment. Each air inlet and total air inlet all are equipped with a primary filter, a medium efficiency filter and a high efficiency filter, and air cleanliness reaches c level, guarantees to get into cabin body 100 and the air cleanliness of discharging into external environment, prevents that the gas from taking dirty letting in cabin body 100 influences the experiment accuracy and prevents that the gas from taking the poison to discharge into the atmosphere polluted environment. The water system 8 comprises a pure water subsystem, a tap water subsystem and a sewage treatment system, wherein the pure water subsystem, the tap water subsystem and the sewage treatment system are communicated with the reagent preparation area 2, the sample preparation area 3, the amplification analysis area 4 and the washing and sterilizing area 5, and the reagent preparation area 2, the sample preparation area 3, the amplification analysis area 4 and the washing and sterilizing area 5 provide water and sewage treatment conditions.

The environment monitoring system is connected with the control system, and comprises a temperature subsystem, a humidity subsystem and a pressure regulating subsystem, and is used for monitoring the temperature and the humidity in the cabin 100 in real time and monitoring and regulating the pressure respectively. Specifically, the pressure regulating subsystem includes a plurality of pressure sensors and a plurality of pressure valves, each pressure valve is respectively disposed at each air inlet and is configured to control an air inlet flow rate of the air inlet, each pressure sensor and the pressure valve are connected to the control system, the control system receives pressure detection information transmitted by the pressure sensor, compares the detection information with set information, and controls the pressure valve to regulate the air inlet flow rate of the air inlet according to a comparison result, thereby regulating a pressure difference between the interior of the cabin 100 and an external environment, or manually regulates the pressure difference through the control system according to a requirement, so as to prevent aerosol from mutual contamination and ensure accuracy of a detection result.

The control system is used for man-machine interaction and data storage, the data storage comprises temperature, humidity, pressure and experimental data storage, data backup can be carried out, and the man-machine interaction comprises data display, manual operation control and adjustment and the like.

In this embodiment, through with reagent preparation district 2, sample preparation district 3, amplification analysis district 4 with wash and eliminate integrated in the container body between fungus district 5, and carry out real-time supervision to temperature, humidity, cleanliness factor and pressure in the container body, and show real-time supervision data in real time, conveniently carry out real-time supervision to the internal environment of container, and adjust the internal pressure of container through pressure governing system, ensure that the pressure in the container body is in the negative pressure state, make the internal external and external formation pressure difference of container, the internal air of container is difficult to flow the external environment of container and pollute, prevent aerosol mutual pollution simultaneously, guarantee the accuracy of testing result. Meanwhile, the ventilation system 7 is connected with the primary filter, the intermediate filter and the high-efficiency filter, the air cleanliness reaches the level c, the exhaust and intake cleanliness is guaranteed, and the cabin body 100 is prevented from being cross-polluted with the external environment through air.

The utility model discloses exempt from the installation, use the freight train transportation, fall to the ground available, as long as transport this equipment to the area of remote area or a large amount of medical equipment demands, can carry out nucleic acid detection, solve the area that lacks the remote area of medical equipment and a large amount of medical equipment demands, can not in time carry out nucleic acid detection's technical problem. The reagent preparation area 2, the sample preparation area 3, the amplification analysis area 4 and the washing and sterilization area 5 are sequentially, independently and communicated and integrated in the container, so that the integration level is high, the operation of each area is continuous, and the cross contamination risk is small.

The ultraviolet disinfection device is provided with a buffer room, an ultraviolet disinfection system and a disinfectant atomization disinfection system are arranged in the buffer room, so that cross contamination of people and objects between the intervals is avoided, human bodies are sterilized and disinfected in time, and the human bodies are prevented from being harmed by viruses or microorganisms.

The above-mentioned embodiments are merely preferred embodiments for fully illustrating the present invention, and the scope of the present invention should not be limited thereby, and modifications and equivalent variations made by those skilled in the art can still be made within the scope of the present invention.

Claims

1. A container type mobile nucleic acid detection biological laboratory is characterized by comprising a cabin body, an environment monitoring system, a ventilation system, a water using system and a control system, wherein the environment monitoring system, the ventilation system, the water using system and the control system are arranged in the cabin body;

a PCR corridor is arranged in the cabin body, a reagent preparation area and an equipment room are respectively arranged at two ends of the PCR corridor, and a sample preparation area, an amplification analysis area and a washing and sterilizing area are sequentially arranged between the reagent preparation area and the equipment room;

the environment monitoring system comprises a temperature subsystem, a humidity subsystem and a pressure regulating subsystem, and is used for monitoring the temperature, the humidity and the pressure in the cabin body in real time and regulating the pressure respectively;

the ventilation system is a negative pressure type fresh air system, one end of the ventilation system is connected with the external environment, the other end of the ventilation system is connected with a main air inlet, the reagent preparation area, the sample preparation area, the amplification analysis area and the washing and sterilizing area are provided with air outlets and air inlets, and the main air inlet is connected with each air outlet;

and the control system is connected with the environment monitoring system and is used for man-machine interaction and data storage.

2. The container-type mobile nucleic acid-detecting biological laboratory according to claim 1, wherein said main air intake opening and each of said air intake openings are provided with a primary filter, a secondary filter and a high efficiency filter, and the air cleanliness reaches class c.

3. The container-type mobile nucleic acid-detecting biological laboratory according to claim 1, wherein said PCR corridor is connected to three buffer compartments, and said three buffer compartments are respectively connected to said reagent preparation compartment, said sample preparation compartment, said amplification and analysis compartment, and said wash-and-kill compartment.

4. The container-type mobile nucleic acid-detecting biological laboratory according to claim 3, wherein a combined water tank and a combined top tank are arranged in the buffer room, the combined water tank comprises a shoe lattice, and the combined top tank comprises a clothes lattice.

5. The container-type mobile nucleic acid-detecting biological laboratory according to claim 3, wherein an ultraviolet disinfection system and a disinfectant atomization disinfection system are arranged in the buffer room.

6. The container-type mobile nucleic acid-detecting biological laboratory according to claim 1, wherein said reagent preparation area, said sample preparation area, said amplification and analysis area, and said decontamination and sterilization area are each provided with a transmission window.

7. The container-type mobile nucleic acid-detecting biological laboratory according to claim 1, wherein said water-consuming system and said ventilation system are disposed in said equipment room, and said equipment room is a separate room, and a side thereof remote from said PCR corridor communicates with the outside.

8. The container-type mobile nucleic acid-detecting biological laboratory according to claim 1, wherein the pressure regulating subsystem comprises a plurality of pressure sensors and a plurality of pressure valves, each pressure valve is respectively disposed at each air inlet and used for controlling the air inlet flow rate of the air inlet, each pressure sensor and each pressure valve are connected to the control system, and the control system receives the pressure detection information transmitted by the pressure sensors and controls the pressure valves to regulate the air inlet flow rate of the air inlets.