CN214174401U

CN214174401U - Single-channel rotary type fluorescence immunoassay analyzer

Info

Publication number: CN214174401U
Application number: CN202023162985.8U
Authority: CN
Inventors: 陈渝峰; 邓苑佐
Original assignee: Chongqing Kang Ju Quan Hong Biotechnology Co ltd
Current assignee: Chongqing Kang Ju Quan Hong Biotechnology Co ltd
Priority date: 2020-12-24
Filing date: 2020-12-24
Publication date: 2021-09-10
Anticipated expiration: 2030-12-24

Abstract

The utility model relates to the field of immunoassay analyzer, and discloses a single-channel rotary fluorescence immunoassay analyzer, which comprises a frame and a detection shell, wherein the detection shell is provided with a plug-in card port, the detection shell is internally provided with a detection mechanism, the detection shell is internally provided with a rotary detection disc, the rotary detection disc is provided with a plurality of incubation grooves which can be just opposite to the plug-in card port, and the incubation grooves are positioned below the detection mechanism; a card outlet mechanism is arranged between the detection shell and the rotary detection disc. The utility model provides a single channel fluorescence immunoassay appearance among the prior art the inconvenient and low problem of detection efficiency of operation that exists when using.

Description

Single-channel rotary type fluorescence immunoassay analyzer

Technical Field

The utility model relates to an immunoassay appearance field, concretely relates to single channel rotation type fluorescence immunoassay appearance.

Background

The biochemical analyzer is one of the common apparatuses for medical detection tests, and can perform analysis and measurement of various reaction types such as a timing method and a continuous monitoring method. The fluorescence immunoassay technology is an important detection and analysis technology in biochemical analysis technology, has the advantages of strong specificity, high sensitivity, good practicability and the like, and is used for measuring bioactive compounds with very low content, such as proteins (enzymes, receptors and antibodies), hormones (steroids, thyroid hormones and phthalein hormones), medicines, microorganisms and the like.

The fluorescence immunoassay analyzer is an apparatus for detecting by utilizing the fluorescence effect of a fluorescent substance, wherein a fluorescence element is arranged on an immunochromatography test strip (or a reagent card), and after the fluorescence element is irradiated by an excitation light source and absorbs incident light with a certain wavelength, the fluorescence with the wavelength slightly longer than that of the incident light can be emitted; the content of the corresponding antigen in the detected object can be obtained by converting the fluorescence intensity into an electric signal and analyzing the electric signal. Most fluorescence immunoassay appearance all is the single channel structure at present, inserts the back with the reagent card from the card slot when using, utilizes fluorescence detection probe to detect the strong and weak back of fluorescence, takes out the back with the reagent card, inserts next reagent card repeated detection again, and the operation is inconvenient and detection efficiency is low.

SUMMERY OF THE UTILITY MODEL

The utility model discloses it is anticipated to provide single channel rotation type fluorescence immunoassay appearance to solve the inconvenient and low problem of detection efficiency of operation that the single channel fluorescence immunoassay appearance exists when using among the prior art.

In order to achieve the above purpose, the utility model adopts the following technical scheme: the single-channel rotary type fluorescence immunoassay analyzer comprises a rack and a detection shell, wherein a card slot is arranged on the detection shell, a detection mechanism is arranged in the detection shell, a rotary type detection disc is arranged in the detection shell, a plurality of incubation grooves capable of being right opposite to the card slot are arranged on the rotary type detection disc, and the incubation grooves are positioned below the detection mechanism; a card outlet mechanism is arranged between the detection shell and the rotary detection disc.

The principle and the advantages of the scheme are as follows: during practical application, among this technical scheme, the frame plays the effect that supports and guarantee stable connection between each part of equipment, detects the shell and plays the effect that whole held and keep apart, can provide a relative independence and sealed dark environment. When the reagent card incubator is used, the reagent card is inserted along the card inserting opening, so that the reagent card incubator is accommodated in the incubation groove on the rotary detection plate, then the rotary detection plate rotates, the next incubation groove is just opposite to the card inserting opening, and an operator can sequentially store a plurality of reagent cards to be detected in the incubation groove. The rotary detection disc can enable the detection cards on the incubation groove to sequentially move to the lower part of the detection mechanism for detection in the rotating process, and after the detection is finished, the rotary detection disc continuously rotates to enable the detected reagent cards to move to the card outlet mechanism along with the incubation groove, so that the automatic card outlet is finished. The technical scheme is simple to operate, can finish continuous detection of a plurality of reagent cards in sequence, and is high in detection efficiency.

Preferably, as an improvement, the detection mechanism comprises a detection head and a lifting assembly for driving the detection head to lift, and the detection head can be opposite to the hatching tank.

In the technical scheme, in the rotating process of the rotary detection disc, a certain reaction time can be given to the reagent on the reagent card, and when the rotary detection disc moves to the position below the detection head, the detection head detects the fluorescence intensity of the reagent; the lifting assembly is used for driving the detection head to lift, so that the movement obstruction between the detection head and the rotary detection disc is avoided, and the stable operation of the equipment is ensured.

Preferably, as an improvement, lifting unit is including rotating the vertical drive lead screw of connection in detecting the shell, the cover be equipped with on the drive lead screw with drive lead screw threaded connection detect the seat, detect the vertical sliding connection of seat on detecting the shell, detect the head and install on detecting the seat.

In the technical scheme, when reagent cards in the hatching tank need to be detected, the screw rod is driven to rotate forwards, so that the detection seat which is in threaded connection with the driving screw rod moves downwards along the axial direction of the driving screw rod, and the detection head is close to the reagent card to be detected to detect; after the detection is finished, the screw rod is driven to rotate reversely, so that the detection seat moves upwards along the axial direction of the screw rod, the detection head is far away from the rotary detection disc and the reagent card, the rotary detection disc can rotate continuously conveniently, the structure is simple, the power transmission is stable,

preferably, as an improvement, one end of the incubation groove is hinged on the rotary detection plate, the card outlet mechanism comprises a fixed plate arranged below the rotary detection plate, and an inclined card outlet channel is arranged on the fixed plate.

In the technical scheme, after the reagent card is detected, the rotary detection disc rotates along the surface of the fixed disc, so that the reagent card continuously moves along with the rotary detection disc and the incubation groove, when the incubation groove moves to the card outlet channel on the fixed disc, because the incubation groove is hinged on the rotary detection disc, one end of the incubation groove, which is far away from the hinged end, can incline downwards, so that the reagent card in the incubation groove slides downwards under the action of self gravity, and the automatic card outlet is completed, and the operation is convenient.

Preferably, as an improvement, a reset component for driving the hatching tank to reset is installed on the card outlet channel, an infrared sensor is installed on the card outlet channel, and the infrared sensor is connected with a controller for driving the reset component.

In the technical scheme, the infrared sensor can be used for monitoring the card outlet condition of the reagent card, and after the infrared sensor detects that the reagent card is discharged from the card outlet channel, the infrared sensor can transmit the signal to the controller, and the controller controls the reset mechanism to drive the hatching tank to reset, so that the autorotation of the subsequent rotary detection tray is avoided being influenced, and the structural design is reasonable.

Preferably, as an improvement, the bottom wall of the hatching tank is provided with a plurality of balls.

According to the technical scheme, the bottom wall of the incubation groove is provided with the ball, so that when the incubation groove is inclined in the card outlet channel, the friction force between the incubation groove and the reagent card can be reduced, and the reagent card can be conveniently discharged.

Preferably, as an improvement, be provided with the motor cabinet in detecting the shell, install driving motor on the motor cabinet, the coaxial rigid coupling of rotation type detection dish has the drive shaft, is connected with the drive belt between drive shaft and the driving motor.

Among this technical scheme, driving motor is used for controlling the rotation of drive shaft, provides stable power source for the rotation type detects the dish.

Preferably, as an improvement, the detection housing is provided with a receiving groove with an upper opening, and the lower end of the card outlet channel is communicated with the receiving groove.

Among this technical scheme, after the reagent card slided along going out the card passageway, can unified slip to keeping in the detection shell, the later stage unified processing of being convenient for.

Drawings

FIG. 1 is a schematic diagram of the external structure of the single-channel rotary fluorescence immunoassay analyzer of the present invention;

FIG. 2 is a longitudinal cross-sectional view of FIG. 1;

FIG. 3 is a top view of the rotary test tray of FIG. 2;

fig. 4 is an enlarged view at a1 in fig. 3.

Detailed Description

The following is further detailed by way of specific embodiments:

reference numerals in the drawings of the specification include: the device comprises a rack 1, a detection shell 2, a stop curtain 3, a display screen 4, a receiving groove 5, a driving shaft 6, a rotary detection disc 7, an incubation groove 8, a ball 9, a fixed disc 10, a driving motor 11, a transmission belt 12, a driving screw 13, a partition plate 14, a strip-shaped hole 15, a driving belt 16, a detection seat 17, a housing 18, a card outlet channel 19, a driving cylinder 20, a piston rod 21 and a positive and negative motor 22.

Example one

This embodiment is substantially as shown in figure 1: single channel rotation type fluorescence immunoassay appearance includes frame 1 and through the detection shell 2 of bolt fastening on frame 1, is provided with detection mechanism and play card mechanism in detecting shell 2.

The detection shell 2 plays a role in integrally accommodating, a card inserting opening (not shown in the figure) is arranged on the detection shell 2, a pull-down type blocking curtain 3 is arranged on the detection shell 2, when the card inserting opening is not used, the blocking curtain is used for blocking and sealing the card inserting opening to prevent the card inserting opening from being polluted or falling ash and the like, and a display screen 4 (the prior art is used for displaying fluorescence imaging on an irradiated reagent card) is further arranged on the detection shell 2. The frame 1 is fixed with an upper opening storage groove 5 through bolts, and the storage groove 5 is positioned on the left side of the detection shell 2.

As shown in fig. 2, a vertically arranged driving shaft 6 is rotatably connected in the detection housing 2, a horizontal rotary detection tray 7 is coaxially and fixedly connected to the top end of the driving shaft 6, and as shown in fig. 3 and 4, nine incubation grooves 8 for accommodating reagent cards are hinged to the rotary detection tray 7, the incubation grooves 8 can be opposite to the card insertion ports, and a plurality of balls 9 are connected in the incubation grooves 8 in a rolling manner. The lower part of the rotary detection disc 7 is provided with a fixed disc 10 which is fixed in the detection shell 2 and is transversely arranged, and the top surface of the fixed disc 10 is contacted with the bottom surface of the rotary detection disc 7. A motor base is fixed in the detection shell 2 through bolts, a driving motor 11 is fixed on the motor base through bolts, and a driving belt 12 is connected between an output shaft of the driving motor 11 and the driving shaft 6.

As shown in fig. 2, the detecting mechanism includes a vertical driving screw 13 rotatably connected in the detecting housing 2, the driving screw 13 is located at one side (rear side) of the rotary detecting plate 7, a vertically-arranged partition plate 14 fixedly connected to the top wall of the detecting housing 2 is arranged between the driving screw 13 and the rotary detecting plate 7, and a vertical strip-shaped hole 15 is formed in the partition plate 14. A positive and negative motor 22 is fixed on the top wall of the detection shell 2 through bolts, and a driving belt 16 is connected between the positive and negative motor 22 and the driving screw rod 13. The cover is equipped with detection seat 17 with it threaded connection on the drive lead screw 13, detects the vertical sliding connection of seat 17 and in detecting shell 2, and the one end of detecting seat 17 passes strip hole 15 and sets up. The detection seat 17 is fixed with a detection head which can be opposite to the incubation groove 8, the detection seat 17 is fixed with a cover shell 18 with an opening at the lower part through bolts, and the cover shell 18 can cover the incubation groove 8. In this embodiment, the detection head is the fluorescence structure of shooing among the prior art, and its principle and connected mode, using-way are prior art, and this embodiment is not optimized to the fluorescence structure of shooing.

The card outlet mechanism comprises a card outlet channel 19 arranged on the fixed disc 10, the card outlet channel 19 is arranged from right to left in an inclined and downward manner, the lower end of the card outlet channel 19 is communicated with the top end opening of the accommodating groove 5, and the incubation groove 8 can be just opposite to the card outlet channel 19. An infrared sensor is mounted on the side wall of the card outlet channel 19, the infrared sensor is in signal connection with a controller, the infrared sensor can transmit signals to the controller, a reset hole is formed in the bottom of the card outlet channel 19, a driving cylinder 20 is arranged below the reset hole, the driving cylinder 20 is fixed on the bottom wall of the detection shell 2 through bolts, and the driving cylinder 20 can enable a piston rod 21 to penetrate out of the reset hole and abut against the hatching tank 8 to reset the hatching tank 8 under the control of the controller. In practical application, the specific model of the infrared sensor and the controller can be selected according to the requirement, which is the prior art particularly commonly used in the field.

The specific implementation process is as follows: before fluorescence detection, after sample is added on the reagent card, an operator pushes the baffle curtain 3 upwards to enable the card insertion opening to leak, then the reagent card is inserted into the incubation groove 8 along the card insertion opening, and as the rolling ball 9 is arranged on the bottom wall of the incubation groove 8, the rolling ball 9 can reduce the friction force between the incubation groove 8 and the reagent card, so that the card insertion process is smooth. Then the driving motor 11 drives the driving shaft 6 to rotate through the driving belt 12, and drives the rotary type detection disc 7 and the incubation groove 8 to rotate, so that the next incubation groove 8 is opposite to the card inserting opening, and then the driving motor 11 is in a stop state, an operator inserts the next reagent card immediately, and the process is repeated.

When the hatching tank 8 rotates to a position right below the detection head, the forward and reverse motor 22 is started, the forward and reverse motor 22 drives the driving screw rod 13 to rotate forward through the driving belt 16, the driving screw rod 13 drives the detection seat 17 in threaded connection with the driving screw rod to move downwards along the isolation plate 14 in the forward rotation process, so that the housing 18 covers the reagent card to be detected, a dark environment for internal detection is formed, at the moment, the detection head detects the fluorescence intensity of the reagent card, and the result is reflected on the display screen 4. After the detection of one reagent card is finished, the forward and reverse motor 22 drives the driving screw rod 13 to rotate reversely, so that the driving screw rod 13 drives the detection seat 17 to move upwards along the isolation plate 14, and further the detection head and the housing 18 move upwards. At the moment, the driving motor 11 is started again to drive the rotary detection disc 7 to rotate, and the next hatching tank 8 is opposite to the detection head, and then the forward and backward motor 22 drives the driving screw rod 13 to rotate forward again, so that the detection head moves down to perform fluorescence detection on the next reagent card.

After the reagent card detection is finished, the rotary detection disc 7 drives the incubation groove 8 and the detected reagent card to rotate in the rotation process, and when the incubation groove 8 rotates to a position right above the card outlet channel 19, the card outlet channel 19 is inclined downwards, and the incubation groove 8 is hinged on the rotary detection disc 7, so that the incubation groove 8 is inclined downwards from the hinged end to the free end and is laid in the card outlet channel 19. At this time, due to the existence of the rolling ball 9, the friction force between the reagent card and the incubation groove 8 is reduced, and at this time, the reagent card slides downwards along the inclined incubation groove 8 and falls into the storage groove 5 to realize concentrated storage and temporary storage for subsequent uniform treatment.

During the process that the reagent card slides down along the card outlet channel 19, after the infrared sensor detects that the reagent card slides down, the infrared sensor transmits a signal to the controller, and the controller controls the driving cylinder 20 to start, so that the piston rod 21 penetrates through the reset hole and pushes the hatching tank 8 upwards to reset. Then the rotary detection disc 7 continues to rotate, so that the next hatching groove 8 is just opposite to the card outlet channel 19, the automatic card outlet process of the next reagent card can be realized, and the operation is convenient.

The above description is only an example of the present invention, and the detailed technical solutions and/or characteristics known in the solutions are not described too much here. It should be noted that, for those skilled in the art, without departing from the technical solution of the present invention, several modifications and improvements can be made, which should also be regarded as the protection scope of the present invention, and these will not affect the effect of the implementation of the present invention and the practicability of the patent. The scope of the claims of the present application shall be determined by the contents of the claims, and the description of the embodiments and the like in the specification shall be used to explain the contents of the claims.

Claims

1. Single channel rotation type fluorescence immunoassay appearance, including frame and detection shell, be provided with the bayonet socket on the detection shell, be provided with detection mechanism, its characterized in that in the detection shell: a rotary detection disc is arranged in the detection shell, a plurality of incubation grooves which can be just opposite to the card inserting ports are arranged on the rotary detection disc, and the incubation grooves are positioned below the detection mechanism; a card outlet mechanism is arranged between the detection shell and the rotary detection disc.

2. The single channel rotary fluoroimmunoassay analyzer of claim 1, wherein: the detection mechanism comprises a detection head and a lifting assembly for driving the detection head to lift, and the detection head can be just opposite to the hatching tank.

3. The single channel rotary fluoroimmunoassay analyzer of claim 2, wherein: the lifting assembly comprises a vertical driving screw rod which is rotatably connected in the detection shell, a detection seat which is in threaded connection with the driving screw rod is sleeved on the driving screw rod, the detection seat is vertically and slidably connected to the detection shell, and the detection head is installed on the detection seat.

4. The single channel rotary fluoroimmunoassay analyzer of claim 3, wherein: one end of the incubation groove is hinged to the rotary detection disc, the card outlet mechanism comprises a fixed disc arranged below the rotary detection disc, and an inclined card outlet channel is arranged on the fixed disc.

5. The single channel rotary fluoroimmunoassay analyzer of claim 4, wherein: the card outlet channel is provided with a reset assembly for driving the hatching tank to reset, the card outlet channel is provided with an infrared sensor, and the infrared sensor is connected with a controller for driving the reset assembly.

6. The single channel rotary fluoroimmunoassay analyzer of claim 5, wherein: a plurality of balls are arranged on the bottom wall of the hatching tank.

7. The single channel rotary fluoroimmunoassay analyzer of claim 6, wherein: the motor base is arranged in the detection shell, the driving motor is installed on the motor base, the rotary detection disc is coaxially and fixedly connected with the driving shaft, and a driving belt is connected between the driving shaft and the driving motor.

8. The single channel rotary fluoroimmunoassay analyzer of claim 7, wherein: the detection shell is provided with an accommodating groove with an opening at the upper part, and the lower end of the card outlet channel is communicated with the accommodating groove.