CN213855123U - Full-automatic exosome extraction element - Google Patents
Full-automatic exosome extraction element Download PDFInfo
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- CN213855123U CN213855123U CN202022646519.0U CN202022646519U CN213855123U CN 213855123 U CN213855123 U CN 213855123U CN 202022646519 U CN202022646519 U CN 202022646519U CN 213855123 U CN213855123 U CN 213855123U
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Abstract
The utility model discloses a full-automatic exosome extraction element, including a plurality of support columns and first motor, the top fixedly connected with base of support column, the top fixedly connected with second centrifuge bucket shell of base, the top swing joint of second centrifuge bucket shell have the second upper cover, one side outer wall fixedly connected with dead lever at second centrifuge bucket shell top, the solid fixed ring of one end fixedly connected with of dead lever installs polymer storage silo in the fixed ring, and the top of polymer storage silo is equipped with sealed lid, one side fixedly connected with second passage of polymer storage silo, one side of second passage are equipped with the solenoid valve, and the other end and the second centrifuge bucket shell of second passage are linked together, the bottom fixedly connected with second motor of base. The utility model discloses a full automatization of extraction process has saved manpower resources, can also filter out the particle impurity in the urine, makes things convenient for the extraction in later stage.
Description
Technical Field
The utility model relates to a biology technical field especially relates to full-automatic exosome extraction element.
Background
In recent years, with the deepened research and understanding of the exosomes, exosome detection is widely applied to noninvasive diagnosis, treatment and monitoring of tumors and diseases by a plurality of clinical research institutions as a novel liquid biopsy hot spot technology, how to efficiently extract exosomes is the key for realizing clinical routine application of the emerging liquid biopsy technology, and the current exosome extraction standard is still a centrifugal method.
At present, exosome extraction element in the market can not fully automatic extraction, and many processes need manual operation of people, extravagant a large amount of manpowers, can not satisfy people's demand, so the full-automatic exosome extraction element of urgent need.
SUMMERY OF THE UTILITY MODEL
The utility model aims at solving the defects existing in the prior art and providing a full-automatic exosome extraction device.
In order to achieve the above purpose, the utility model adopts the following technical scheme:
the full-automatic exosome extraction device comprises a plurality of support columns and a first motor, wherein the tops of the support columns are fixedly connected with a base, the top of the base is fixedly connected with a second centrifugal barrel shell, the top of the second centrifugal barrel shell is movably connected with a second upper cover, the outer wall of one side of the top of the second centrifugal barrel shell is fixedly connected with a fixed rod, one end of the fixed rod is fixedly connected with a fixed ring, a polymer storage bin is installed in the fixed ring, the top of the polymer storage bin is provided with a sealing cover, one side of the polymer storage bin is fixedly connected with a second guide pipe, one side of the second guide pipe is provided with an electromagnetic valve, the other end of the second guide pipe is communicated with the second centrifugal barrel shell, the bottom of the base is fixedly connected with a second motor, one end of an output shaft of the second motor is fixedly connected with a second fixed block, and the top of the second fixed block is fixedly connected with a second centrifugal inner barrel, a plurality of second through-holes have been seted up to the circumference inner wall of centrifugal inner tube of second, and the circumference inner wall fixedly connected with second filter membrane of the centrifugal inner tube of second, one side fixedly connected with discharging pipe of second centrifugal barrel shell, one side of discharging pipe are equipped with the valve, the top of base is equipped with control panel, control panel and second motor and solenoid valve electric connection.
As the utility model discloses scheme further again, the circumference inner wall fixedly connected with second slide rail of second centrifugation bucket shell, swing joint have a plurality of second sliders in the second slide rail, one side of second slider and one side outer wall fixed connection of the centrifugal inner tube of second.
As the utility model discloses scheme further again, a plurality of fixed columns of top fixedly connected with of base, the first centrifugation bucket shell of top fixedly connected with of fixed column.
As a further proposal, one side of the upper surface of the first centrifugal barrel shell is fixedly connected with a hinge and the other side of the hinge is fixedly connected with a first upper cover.
As the utility model discloses scheme further still, first motor passes through the bolt fastening at the bottom outer wall of first centrifugation bucket shell, first motor and control panel electric connection, the first fixed block of one end fixedly connected with of first motor output shaft, the first centrifugation inner tube of top fixedly connected with of first fixed block, and a plurality of first through-holes, the first filter membrane of circumference inner wall fixedly connected with of first centrifugation inner tube have been seted up to the circumference inner wall of first centrifugation inner tube.
As the utility model discloses scheme further again, the first slide rail of circumference inner wall fixedly connected with of first centrifugation bucket shell, the swing joint of first slide rail has a plurality of first sliders, one side of first slider and the circumference outer wall fixed connection of first centrifugation inner tube.
As a further proposal, the first guide pipe is fixedly connected with one side of the first centrifugal barrel shell.
The utility model has the advantages that:
1. the utility model discloses an opening and the rotation time of first motor of control panel control and second motor to can carry out the centrifugation to the exosome automatically and draw, opening of rethread control panel control solenoid valve, thereby realize automatic interpolation polymer, and then realize the full automatization of extraction process, saved manpower resources.
2. The utility model discloses a setting of first motor and first centrifugal inner tube, first fixed block rotates under the drive of first motor to drive first centrifugal inner tube and first centrifugal barrel shell and rotate together and carry out centrifugal edulcoration, thereby filter out the particle impurity in the urine, make things convenient for the drawing in later stage.
3. The utility model discloses a setting of second motor and the centrifugal inner tube of second, the second fixed block rotates under the second motor drives to it carries out the centrifugation and draws to drive the centrifugal inner tube of second and second centrifugation bucket shell and rotate together, thereby draws the exosome in the supernatant out, easy operation, convenient and fast.
Drawings
Fig. 1 is a schematic view of a front cross-sectional structure of the fully automatic exosome extraction device provided by the present invention;
fig. 2 is a schematic view of a top view structure of the fully automatic exosome extraction device provided by the present invention;
fig. 3 is the perspective structure diagram of the full-automatic exosome extraction device provided by the utility model.
In the figure: 1. a support pillar; 2. a base; 3. fixing a column; 4. a first motor; 5. a first fixed block; 6. a first filter membrane; 7. a first centrifugal inner cylinder; 8. a first slide rail; 9. a hinge; 10. a first upper cover; 11. a first slider; 12. a first material guide pipe; 13. a second slider; 14. a second upper cover; 15. fixing the rod; 16. a sealing cover; 17. a fixing ring; 18. a polymer storage bin; 19. an electromagnetic valve; 20. a second material guide pipe; 21. a second slide rail; 22. a second centrifugal inner cylinder; 23. a second filter membrane; 24. a valve; 25. a discharge pipe; 26. a second motor; 27. a second fixed block; 28. a second centrifuge bucket housing; 29. a control panel; 30. a first centrifuge bucket housing.
Detailed Description
The technical solutions in the embodiments of the present invention will be described clearly and completely with reference to the accompanying drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only some embodiments of the present invention, not all embodiments. It should be noted that unless otherwise explicitly stated or limited, the terms "mounted," "connected," and "disposed" are to be construed broadly and their meaning in the context of this patent may be understood by those skilled in the art as appropriate.
Referring to fig. 1 to 3, the full-automatic exosome extraction device comprises a plurality of support columns 1 and a first motor 4, a base 2 is fixed on the top of each support column 1 through a bolt, a control panel 29 is arranged on the top of each base 2, a second centrifuge bucket shell 28 is fixed on the top of each base 2 through a bolt, a second upper cover 14 is rotatably connected on the top of each second centrifuge bucket shell 28, a fixing rod 15 is fixed on the outer wall of one side of the top of each second centrifuge bucket shell 28 through a bolt, a fixing ring 17 is fixed on one end of each fixing rod 15 through a bolt, a polymer storage bin 18 is installed in each fixing ring 17, a sealing cover 16 is arranged on the top of each polymer storage bin 18, a second guide tube 20 is fixed on one side of each polymer storage bin 18 through a bolt, an electromagnetic valve 19 is arranged on one side of each second guide tube 20, the electromagnetic valve 19 is controlled to be opened by the control panel 29, and polymer falls into supernatant from the second guide tubes 20, the other end of the second material guiding pipe 20 is communicated with a second centrifugal barrel shell 28, a second motor 26 is fixed at the bottom of the base 2 through bolts, a control panel 29 is electrically connected with the second motor 26 and the electromagnetic valve 19, a second fixing block 27 is fixed at one end of an output shaft of the second motor 26 through bolts, the second fixing block 27 is driven by the second motor 26 to rotate, a second centrifugal inner barrel 22 is fixed at the top of the second fixing block 27 through bolts, the second centrifugal barrel shell 28 and the second centrifugal inner barrel 22 are driven to rotate together to extract secretion bodies, a plurality of second through holes are formed in the circumferential inner wall of the second centrifugal inner barrel 22, a second filter membrane 23 is bonded on the circumferential inner wall of the second centrifugal inner barrel 22, a discharging pipe 25 is fixed on one side of the second centrifugal barrel shell 28 through bolts, and a valve 24 is arranged on one side of the discharging pipe 25.
The utility model discloses in, the circumference inner wall of second centrifuge bucket shell 28 has second slide rail 21 through the bolt fastening, sliding connection has a plurality of second sliders 13 in the second slide rail 21, second slider 13 slides in second slide rail 21 and leads to the rotation of second centrifuge bucket shell 28, one side of second slider 13 and one side outer wall fixed connection of second centrifuge inner tube 22, there are a plurality of fixed columns 3 at the top of base 2 through the bolt fastening, there is first centrifuge bucket shell 30 at the top of fixed column 3 through the bolt fastening, there is hinge 9 one side of first centrifuge bucket shell 30 upper surface through the bolt fastening, hinge 9's opposite side has first upper cover 10 through the bolt fastening, open first upper cover 10, fall the urine into in the first centrifuge inner tube 7.
Particularly, the first motor 4 is fixed on the outer wall of the bottom of the first centrifugal barrel shell 30 through a bolt, the first motor 4 is electrically connected with the control panel 29, one end of the output shaft of the first motor 4 is fixed with a first fixing block 5 through a bolt, the first fixing block 5 is driven by the first motor 4 to rotate, the top of the first fixing block 5 is fixed with a first centrifugal inner barrel 7 through a bolt so as to drive the first centrifugal barrel shell 30 and the first centrifugal inner barrel 7 to rotate together, the circumferential inner wall of the first centrifugal inner barrel 7 is provided with a plurality of first through holes, the circumferential inner wall of the first centrifugal inner barrel 7 is bonded with a first filter membrane 6, the circumferential inner wall of the first centrifugal barrel shell 30 is fixed with a first slide rail 8 through a bolt, the first slide rail 8 is connected with a plurality of first slide blocks 11 in a sliding manner, and simultaneously drives the first slide blocks 11 to slide in the first slide rail 8 so as to centrifugally remove impurities from urine, one side of the first sliding block 11 is fixedly connected with the circumferential outer wall of the first centrifugal inner cylinder 7, and one side of the first centrifugal barrel shell 30 is fixed with a first material guide pipe 12 through a bolt.
The working principle of the embodiment is as follows: when the device is used, firstly, the first upper cover 10 is opened, urine is poured into the first centrifugal inner barrel 7, then, the control panel 29 controls the first motor 4 to be started, the first fixing block 5 is driven by the first motor 4 to rotate, so that the first centrifugal barrel shell 30 and the first centrifugal inner barrel 7 are driven to rotate together, the first sliding block 11 is driven to slide in the first sliding rail 8, so that centrifugal impurity removal is carried out on the urine, particle impurities in the urine are remained in the first centrifugal inner barrel 7, supernatant is thrown into the first centrifugal barrel shell 30 from the first through hole through the first filter membrane 6, then, the supernatant flows into the second centrifugal inner barrel 22 from the first guide pipe 12, then, the control panel 29 controls the electromagnetic valve 19 to be opened, polymers fall into the supernatant from the second guide pipe 20, after standing for a period of time, the control panel 29 controls the second motor 26 to be started, the second fixing block 27 is driven by the second motor 26 to rotate, thereby drive second centrifugal barrel shell 28 and second centrifugal inner tube 22 and rotate together and carry out the extraction of secretion, the secretion is stayed in second centrifugal inner tube 22, and the waste liquid passes through second filter membrane 23, gets rid of to the second centrifugal barrel shell 28 in from the second through-hole, then, opens valve 24, discharges the waste liquid from discharging pipe 25.
The above, only be the concrete implementation of the preferred embodiment of the present invention, but the protection scope of the present invention is not limited thereto, and any person skilled in the art is in the technical scope of the present invention, according to the technical solution of the present invention and the utility model, the concept of which is equivalent to replace or change, should be covered within the protection scope of the present invention.
Claims (7)
1. The full-automatic exosome extraction device comprises a plurality of support columns (1) and a first motor (4), and is characterized in that the top of each support column (1) is fixedly connected with a base (2), the top of each base (2) is fixedly connected with a second centrifuge bucket shell (28), the top of each second centrifuge bucket shell (28) is movably connected with a second upper cover (14), the outer wall of one side of the top of each second centrifuge bucket shell (28) is fixedly connected with a fixing rod (15), one end of each fixing rod (15) is fixedly connected with a fixing ring (17), a polymer storage bin (18) is installed in each fixing ring (17), the top of each polymer storage bin (18) is provided with a sealing cover (16), one side of each polymer storage bin (18) is fixedly connected with a second guide pipe (20), one side of each second guide pipe (20) is provided with an electromagnetic valve (19), and the other end of each second guide pipe (20) is communicated with the second centrifuge bucket shell (28), the bottom fixedly connected with second motor (26) of base (2), the one end fixedly connected with second fixed block (27) of second motor (26) output shaft, the centrifugal inner tube of top fixedly connected with second (22) of second fixed block (27), a plurality of second through-holes have been seted up to the circumference inner wall of the centrifugal inner tube of second (22), the circumference inner wall fixedly connected with second filter membrane (23) of the centrifugal inner tube of second (22), one side fixedly connected with discharging pipe (25) of second centrifugal barrel shell (28), one side of discharging pipe (25) is equipped with valve (24), the top of base (2) is equipped with control panel (29), control panel (29) and second motor (26) and solenoid valve (19) electric connection.
2. The full-automatic exosome extraction device according to claim 1, wherein a second sliding rail (21) is fixedly connected to the inner circumferential wall of the second centrifugal barrel housing (28), a plurality of second sliding blocks (13) are movably connected in the second sliding rail (21), and one side of each second sliding block (13) is fixedly connected with the outer wall of one side of the second centrifugal inner barrel (22).
3. The fully automatic exosome extraction device according to claim 1, wherein a plurality of fixed columns (3) are fixedly connected to the top of the base (2), and a first centrifuge bucket housing (30) is fixedly connected to the top of the fixed columns (3).
4. A fully automatic exosome extraction device according to claim 3, wherein a hinge (9) is fixedly connected to one side of the upper surface of the first centrifuge bucket housing (30), and a first upper cover (10) is fixedly connected to the other side of the hinge (9).
5. The full-automatic exosome extraction device according to claim 4, wherein the first motor (4) is fixed on the outer wall of the bottom of the first centrifugal barrel shell (30) through a bolt, the first motor (4) is electrically connected with the control panel (29), one end of an output shaft of the first motor (4) is fixedly connected with a first fixing block (5), the top of the first fixing block (5) is fixedly connected with a first centrifugal inner barrel (7), a plurality of first through holes are formed in the circumferential inner wall of the first centrifugal inner barrel (7), and a first filter membrane (6) is fixedly connected with the circumferential inner wall of the first centrifugal inner barrel (7).
6. The full-automatic exosome extraction device according to claim 5, wherein a first sliding rail (8) is fixedly connected to the circumferential inner wall of the first centrifugal barrel housing (30), a plurality of first sliding blocks (11) are movably connected to the first sliding rail (8), and one side of each first sliding block (11) is fixedly connected to the circumferential outer wall of the first centrifugal inner barrel (7).
7. The fully automatic exosome extracting device according to claim 3, wherein a first feeding tube (12) is fixedly connected to one side of the first centrifuge bucket housing (30).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202022646519.0U CN213855123U (en) | 2020-11-16 | 2020-11-16 | Full-automatic exosome extraction element |
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| Application Number | Priority Date | Filing Date | Title |
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| CN202022646519.0U CN213855123U (en) | 2020-11-16 | 2020-11-16 | Full-automatic exosome extraction element |
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| CN213855123U true CN213855123U (en) | 2021-08-03 |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114015547A (en) * | 2021-11-05 | 2022-02-08 | 中南大学湘雅医院 | A aseptic extraction equipment of double linkage for preparation of mesenchymal stem cell exosome |
| CN114054219A (en) * | 2021-11-03 | 2022-02-18 | 李晶 | Separator of extracellular secretion body |
| CN115926956A (en) * | 2023-02-07 | 2023-04-07 | 山东灵犀生物科技有限公司 | Cell culture exosome collection device |
-
2020
- 2020-11-16 CN CN202022646519.0U patent/CN213855123U/en active Active
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114054219A (en) * | 2021-11-03 | 2022-02-18 | 李晶 | Separator of extracellular secretion body |
| CN114015547A (en) * | 2021-11-05 | 2022-02-08 | 中南大学湘雅医院 | A aseptic extraction equipment of double linkage for preparation of mesenchymal stem cell exosome |
| CN114015547B (en) * | 2021-11-05 | 2022-10-11 | 中南大学湘雅医院 | A aseptic extraction equipment of double linkage for preparation of mesenchymal stem cell exosome |
| CN115926956A (en) * | 2023-02-07 | 2023-04-07 | 山东灵犀生物科技有限公司 | Cell culture exosome collection device |
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