CN213843134U

CN213843134U - Convenient-to-use high performance liquid chromatograph for producing oseltamivir

Info

Publication number: CN213843134U
Application number: CN202022574599.3U
Authority: CN
Inventors: 陈晓
Original assignee: Suzhou Aoputuo New Material Co ltd
Current assignee: Suzhou Aoputuo New Material Co ltd
Priority date: 2020-11-09
Filing date: 2020-11-09
Publication date: 2021-07-30
Anticipated expiration: 2030-11-09

Abstract

The utility model provides a high performance liquid chromatograph convenient to use for producing oseltamivir, including the thermostatic bath, be provided with the fixation clamp subassembly in the thermostatic bath, synchronous dwang and helping hand handle, left wheel through the fixation clamp subassembly, right wheel, conveyer belt and engaged with left gear and right gear, the left flange of left arm structure is in step with the right flange of right arm structure in the control fixation clamp or back of the body motion mutually, thereby press from both sides tightly or loosen the chromatographic column, through fixation clamp subassembly and synchronous dwang, the synchronous change fixation clamp size when matcing different diameter big or small chromatographic columns, reduce because the inhomogeneous damage that produces the chromatographic column of atress.

Description

Convenient-to-use high performance liquid chromatograph for producing oseltamivir

Technical Field

The utility model relates to a liquid chromatograph technical field, concretely relates to high performance liquid chromatograph who is used for producing oseltamivir convenient to use.

Background

Oseltamivir is an anti-influenza virus drug and is used for treating and preventing influenza, and the oseltamivir is widely used in clinical application in a global range and has a large demand. The production process of oseltamivir needs to use a high performance liquid chromatograph to detect the medicament. A high-performance liquid chromatograph uses liquid as mobile phase, and adopts high-pressure transfusion system to pump the mobile phase of single solvent with different polarity or mixed solvent and buffer solution with different proportions into chromatographic column filled with stationary phase, and after the components in the column are separated, the mobile phase is fed into detector to make detection so as to implement analysis of sample.

Document CN209542543U discloses a high performance liquid chromatograph, including instrument, pipe, heat preservation storehouse, chromatographic column and expansion bracket, the upside of instrument is provided with places the box, and the inside of placing the box is provided with reagent storehouse, the right-hand member of pipe is connected with reagent storehouse, the inside in heat preservation storehouse is provided with pretreatment column, and pretreatment column's lower extreme is connected with the guard post, chromatographic column's upper end is connected with the guard post, the right side rigid coupling of expansion bracket is on the rotating turret, and the right side rigid coupling of rotating turret is in the left side of instrument, reduces to minimum through this kind have the sealed storehouse body and the heat preservation storehouse body factor that influences the testing result, has improved the precision of testing result greatly, has effectually shortened the time that the analysis appraisal needs simultaneously, has improved work efficiency.

Document CN110426484A discloses a column oven for a liquid chromatograph and a liquid chromatograph, which comprises a box body; a loading chamber is arranged in the box body, an installation seat is arranged in the loading chamber, and a chromatographic column is arranged in the installation seat; a spiral groove is formed in the inner side wall of the mounting seat, and a spiral heating pipe is arranged in the spiral groove; insulation boards are arranged on two side walls of the mounting seat, and mounting cavities are formed in the insulation boards; an electric heating air box is arranged on the outer wall of the heat insulation plate and is communicated with the spiral heating pipe through an elastic air guide hose, and the elastic air guide hose penetrates through the heat insulation plate; a liquid guide pipe is arranged in the mounting cavity, and the liquid guide pipe is overlapped, wound and attached to the elastic air guide hose; the inside of the liquid guide pipe is filled with boiling liquid, and the boiling liquid is positioned at the winding position of the liquid guide pipe; the phenomenon that the temperature in the loading chamber or the mounting seat is inconsistent due to uneven heating is effectively prevented, and the recovery rate of the target product is effectively improved.

However, due to different requirements on the separation degree and the retention value of a sample, the existing chromatographic columns have various models and specifications, and a fixing clamp with a matched size is needed for clamping chromatographic columns with different thicknesses, while the fixing clamp of the constant temperature tank in the existing high performance liquid chromatograph has a single structure and is inconvenient to use, so that a worker needs to repeatedly replace the fixing clamp if clamping the chromatographic columns, manpower and material resources are wasted, and the chromatographic columns to be measured and internal samples are easily damaged in the operation process.

SUMMERY OF THE UTILITY MODEL

In order to solve the problem, the utility model provides a convenient to use's high performance liquid chromatograph for producing oseltamivir.

In order to realize the purpose, the utility model discloses a technical scheme as follows:

a convenient to use's high performance liquid chromatograph for producing oseltamivir, includes the thermostatic bath, its characterized in that: a fixed clamp assembly, a synchronous rotating rod and a power-assisted handle are arranged in the constant-temperature groove, the fixed clamp assembly comprises a first fixed clamp assembly and a second fixed clamp assembly, the first fixed clamp assembly comprises a first left arm structure, a first right arm structure and a first supporting platform, the first left arm structure comprises a first left conveyor belt, a first left convex plate, a first left arm left wheel, a first left arm right wheel, a first left arm support and a first left gear, the first left arm left wheel and the first left arm right wheel are connected through the first left conveyor belt, a bearing of the first left arm left wheel, a bearing of the first left arm right wheel and a bearing of the first left gear are respectively and fixedly connected to the first left arm support, and the first left conveyor belt is fixedly connected with the first left convex plate; the first right arm structure comprises a first right conveyor belt, a first right convex plate, a first right arm left wheel, a first right arm right wheel, a first right arm support and a first right gear, the first right arm left wheel and the first right arm right wheel are connected through the first right conveyor belt, a bearing of the first right arm left wheel, a bearing of the first right arm right wheel and a bearing of the first right gear are fixedly connected to the first right arm support respectively, and the first right conveyor belt is fixedly connected with the first right convex plate; the first left arm support and the first right arm support are fixedly connected to the thermostatic bath, and the first left gear is meshed with the first right gear; the second fixing clamp assembly is the same as the first fixing clamp assembly in structure and comprises a second left arm structure, a second right arm structure and a second saddle, the second left arm structure comprises a second left conveyor belt, a second left convex plate, a second left arm left wheel, a second left arm right wheel, a second left arm support and a second left gear, the second left arm left wheel and the second left arm right wheel are connected through the second left conveyor belt, a bearing of the second left arm left wheel, a bearing of the second left arm right wheel and a bearing of the second left gear are fixedly connected to the second left arm support respectively, and the second left conveyor belt is fixedly connected with the second left convex plate; the second right arm structure comprises a second right conveyor belt, a second right convex plate, a second right arm left wheel, a second right arm right wheel, a second right arm support and a second right gear, the second right arm left wheel and the second right arm right wheel are connected through the second right conveyor belt, a bearing of the second right arm left wheel, a bearing of the second right arm right wheel and a bearing of the second right gear are fixedly connected to the second right arm support respectively, and the second right conveyor belt is fixedly connected with the second right convex plate; the second left arm support and the second right arm support are fixedly connected to the thermostatic bath, and the second left gear is meshed with the second right gear; the synchronous dwang is used for making first left arm left wheel with second left arm left wheel synchronous rotation, helping hand handle fixed connection in first left arm left wheel is kept away from on the bearing of synchronous dwang. Through the fixed chromatographic column in clearance that left flange, the right flange formed in the fixation clamp subassembly, through helping hand handle control the fixation clamp subassembly makes the left flange and the right flange in each fixation clamp subassembly step up or open through synchronous dwang, engaged with left gear and right gear, matches the chromatographic column of different diameters, reduces the non-uniform by the atress of fixed position of chromatographic column.

Preferably, a conveyor belt gap is formed between the first left conveyor belt and the first right conveyor belt, and the first pallet is placed on the conveyor belt gap and is in sliding connection with the first left conveyor belt and the first right conveyor belt; and a conveyor belt gap is formed between the second left conveyor belt and the second right conveyor belt, a second saddle is placed on the conveyor belt gap, and the second saddle is respectively connected with the second left conveyor belt and the second right conveyor belt in a sliding manner.

Preferably, a first flat anti-skid pad is arranged on the upper surface of the first pallet; and a second flat anti-skid pad is arranged on the upper surface of the second tray table.

Preferably, the constant temperature bath be provided with the tooth way subassembly, the tooth way subassembly includes preceding walking gear, back walking gear and tooth way rack, first fixation clamp subassembly fixed connection in preceding walking gear bearing, second fixation clamp subassembly fixed connection in back walking gear bearing, preceding walking gear with back walking gear with tooth way rack toothing, preceding walking gear shaft fixed connection first left arm support with first right arm support, the gear shaft fixed connection of back walking gear in second left arm support with second right arm support.

Preferably, a bearing of a gear shaft of the front walking gear is fixedly connected with one end of a front support, the other end of the front support is fixedly connected with a front sliding block, a tooth path sliding groove is fixedly installed on the thermostatic groove, the front sliding block is located in the tooth path sliding groove, the front sliding block is connected with the tooth path sliding groove in a sliding mode, and the length direction of the tooth path sliding groove is the same as the length direction of the tooth path rack; the bearing of back walking gear shaft fixedly connected with one end of after-poppet, the other end fixedly connected with back slider of after-poppet, back slider is located the tooth way spout, back slider with tooth way spout sliding connection.

Preferably, the number of the front sliding blocks is two, the number of the rear sliding blocks is two, and the number of the tooth path sliding grooves corresponding to the front sliding blocks is two.

Preferably, the synchronous dwang includes first bull stick and second bull stick, first bull stick fixed connection in the epaxial of first left arm left wheel, second bull stick fixed connection in the epaxial of second left arm left wheel, first bull stick with the junction of second bull stick is provided with the spline.

Preferably, the surface of the power-assisted handle is provided with an anti-skid bulge.

Preferably, the face of the first left convex plate contacting the chromatographic column to be tested is provided with a first left non-slip mat, the face of the first right convex plate contacting the chromatographic column to be tested is provided with a first right non-slip mat, the face of the second left convex plate contacting the chromatographic column to be tested is provided with a second left non-slip mat, and the face of the second right convex plate contacting the chromatographic column to be tested is provided with a second right non-slip mat.

Preferably, the precision grades of the rack, the front walking gear and the rear walking gear reach DIN5 grade.

Preferably, the accuracy grade of the first left gear, the first right gear, the second left gear and the second right gear reaches DIN4 grade.

The utility model discloses following beneficial effect has:

(1) the utility model discloses a fixation clamp subassembly, synchronous dwang and helping hand handle make the staff open or fold through rotating the left arm mechanism and the right arm mechanism that the helping hand handle drove first fixation clamp subassembly and second fixation clamp subassembly in step, can match the chromatographic column of different diameters size, can change the fixation clamp size in step simultaneously, reduce because the inhomogeneous damage that produces the chromatographic column of atress.

(2) The utility model discloses a tooth way subassembly, staff change first fixation clamp subassembly and second fixation clamp subassembly relative position through promoting fore-stock and after-poppet, realize matcing different length chromatographic columns and keep the stable function of chromatographic column clamping state.

Drawings

Fig. 1 is a side view of the overall shaft of the present invention.

Fig. 2 is an enlarged view of a portion I of fig. 1.

Fig. 3 is a front view of the present invention.

Fig. 4 is a cross-sectional view taken along line a-a of fig. 3.

Fig. 1 and 5 are top views of the first fixing clip assembly, the second fixing clip assembly and the synchronous rotating rod of the present invention.

In the figure: 1 is a first stationary clamp assembly, 11 is a first left arm structure, 111 is a first left belt, 112 is a first left flange, 1121 is a first left cleat, 113 is a first left arm left wheel, 114 is a first left arm right wheel, 115 is a first left arm bracket, 116 is a first left gear, 12 is a first right arm structure, 121 is a first right belt, 122 is a first right flange, 1221 is a first right cleat, 124 is a first right arm right wheel, 125 is a first right arm bracket, 126 is a first right gear, 14 is a first pallet, 141 is a first flat cleat, 2 is a second stationary clamp assembly, 21 is a second left arm structure, 22 is a second right arm structure, 24 is a second pallet, 3 is a rack bar assembly, 31 is a front travel gear, 311 is a front slider, 32 is a

rear support

312, 32 is a rear slider, 321 is a rear slider, 322 is a rear support, 33 is a rack bar, 34 is a rack bar, 4 is a synchronous chute, 41 is a first rotating rod, 42 is a second rotating rod, 5 is a thermostatic bath, 6 is a power-assisted handle, and 61 is an anti-skid bump.

Detailed Description

The present invention will be further described with reference to the following detailed description of the drawings.

As shown in fig. 3, a convenient-to-use high performance liquid chromatograph for producing oseltamivir comprises a thermostatic bath 5, wherein a fixing clamp assembly for clamping a chromatographic column, a synchronous rotating rod 4 for synchronizing the movement of the fixing clamp, and a power-assisted handle 6 are arranged in the thermostatic bath 5. The fixing clamp assembly comprises a first fixing clamp assembly 1 and a second fixing clamp assembly 2.

As shown in fig. 1, the first fixing clip assembly 1 includes a first left arm structure 11 and a first right arm structure 12, the first left arm structure 11 includes a first left conveyor belt 111, a first left protruding plate 112, a first left arm left wheel 113, a first left arm right wheel 114, a first left arm bracket 115 and a first left gear 116, the first left arm left wheel 113 and the first left arm right wheel 114 are connected by the first left conveyor belt 111, the first left protruding plate 112 is fixedly connected to the first left conveyor belt 111, and a bearing of the first left arm left wheel 113, a bearing of the first left arm right wheel 114 and a bearing of the first left gear 116 are respectively fixedly connected to the first left arm bracket 115; as shown in fig. 3, the first left arm left wheel 113 is shielded by the first left gear 116, and the first left arm left wheel 113 is actually positioned inside the first left transfer belt 111. As shown in fig. 4, the first right arm structure 12 includes a first right conveyor belt 121, a first right protruding plate 122, a first right arm left wheel (which is hidden by a first right gear 126 and thus not labeled in fig. 4), a first right arm right wheel 124, a first right arm bracket 125, and a first right gear 126, wherein the first right arm left wheel and the first right arm right wheel 124 are connected by the first right conveyor belt 121, the first right protruding plate 122 is fixedly connected to the first right conveyor belt 121, and a bearing of the first right arm left wheel, a bearing of the first right arm right wheel 124, and a bearing of the first right gear 126 are respectively fixedly connected to the first right arm bracket 125; the first left arm bracket 115 and the first right arm bracket 125 are fixedly connected to the thermostatic bath 5; the first left gear 116 and the first right gear 126 are meshed. As shown in fig. 1 and 4, the first left arm structure 11 is disposed opposite to the first right arm structure 12, so that a gap for accommodating a chromatography column to be tested is formed between the first left convex plate 112 and the first right convex plate 122.

As shown in fig. 1 and 5, the second fixing clip assembly 2 has the same structure as the first fixing clip assembly 1, the second fixing clip assembly 2 includes a second left arm structure 21, a second right arm structure 22 and a second saddle 24, the second left arm structure 21 includes a second left conveyor belt, a second left convex plate, a second left arm left wheel, a second left arm right wheel, a second left arm bracket and a second left gear, the second left arm left wheel and the second left arm right wheel are connected through the second left conveyor belt, a bearing of the second left arm left wheel, a bearing of the second left arm right wheel and a bearing of the second left gear are respectively and fixedly connected to the second left arm bracket, and the second left conveyor belt is fixedly connected to the second left convex plate; the second right arm structure 22 includes a second right conveyor belt, a second right convex plate, a second right arm left wheel, a second right arm right wheel, a second right arm support and a second right gear, the second right arm left wheel and the second right arm right wheel are connected through the second right conveyor belt, a bearing of the second right arm left wheel, a bearing of the second right arm right wheel and a bearing of the second right gear are respectively and fixedly connected to the second right arm support, and the second right conveyor belt is fixedly connected with the second right convex plate; the second left arm support with the second right arm support fixed connection in the constant temperature bath 5, the second left gear with the meshing of the second right gear, the second left arm structure 21 with the second right arm structure 22 sets up relatively, so that the second left flange with form the clearance that holds the chromatographic column that awaits measuring between the second right flange.

As shown in fig. 1 and 3, the synchronous rotating rod 4 is used for synchronously rotating the first left arm left wheel 113 and the second left arm left wheel. As shown in fig. 1 and 5, the assist handle 6 is fixedly connected to a bearing of the first left arm left wheel 113 away from the synchronous rotating rod 4.

When the worker wants to reduce the clamping diameter of the first fixing clamp assembly 1, the worker rotates the power-assisted handle 6, the first left arm left wheel 113 connected to the power-assisted handle 6 drives the first left conveyor belt 111 to move, so that the side of the first left conveyor belt 111 where the first left protruding plate 112 is fixed moves towards the first right protruding plate 122, and the first left protruding plate 112 is driven to move towards the first right protruding plate 122. Since the shaft of the first left gear 116 is fixedly connected to the shaft of the first left arm right wheel 114 and the shaft of the first right gear 126 is fixedly connected to the shaft of the first right arm left wheel (not shown), the movement of the first left transmission belt 111 drives the first left arm right wheel 114 to rotate, the rotation of the first left arm right wheel 114 drives the first left gear 116 to rotate, the rotation of the first left gear 116 drives the first right arm left wheel to rotate, the rotation of the first right arm left wheel drives the first right conveyor belt 121 to move, due to the engagement of the first left gear 116 and the first right gear 126, the rotation directions of the first left gear 116 and the first right gear 126 are opposite, so that the first right protruding plate 122 moves toward the first left protruding plate 112, so as to drive the first left convex plate 112 and the first right convex plate 122 to move towards each other through the power-assisted handle 6. A worker can adjust the size of the gap by rotating the power-assisted handle 6 to clamp or loosen the chromatographic column to be tested, the first left convex plate 112 and the first right convex plate 122 move oppositely or reversely at the same time, and the distance between the first left convex plate 112 and the first right convex plate 122 can be synchronously reduced. The shape, structure, connection mode and transmission principle of the second left convex plate and the second right convex plate in the second fixing clip assembly 2 are the same as those of the first left convex plate 112 and the first right convex plate 122 in the first fixing clip assembly 1, and are not described herein again.

As shown in fig. 4, in the first fixing clip assembly 1, a first left protruding plate 112 and a first right protruding plate 122 protruding upwards from the first right arm structure 12 are used for clamping the tube wall of the chromatographic column to be tested, a conveyor belt gap is formed between the first left conveyor belt 111 and the first right conveyor belt 121, in fig. 4, the conveyor belt gap is partially covered by a first left gear 116 and a first right gear 126, and the first pallet 14 is placed on the conveyor belt gap and slidably connected with the first left conveyor belt 111 and the first right conveyor belt 121. The first support table 14 is used for supporting the bottom surface of the tube body of the chromatographic column to be tested. The second pallet 24 in the second fixing clip assembly 2 and the first pallet 14 in the first fixing clip assembly 1 have the same shape, structure and use principle, and are not described herein again.

As shown in fig. 4, the top surface of the first pallet 14 is provided with a first flat non-slip pad 141, which increases the friction with the contact surface of the chromatographic column to be tested, so as to prevent the chromatographic column to be tested from sliding and improve the stability of clamping the chromatographic column to be tested. The shape, structure and usage principle of the second flat anti-skid pad in the second fixing clip assembly 2 are the same as those of the first flat anti-skid pad 141 in the first fixing clip assembly 1, and are not described herein again.

As shown in fig. 3 and 4, a tooth path component 3 is arranged at the bottom of the thermostatic bath 5, the tooth path component 3 comprises a front walking gear 31, a rear walking gear 32 and a tooth path rack 33, the front walking gear 31 is fixedly connected with the first fixing clamp component 1, the rear walking gear 32 is fixedly connected with the second fixing clamp component 2, a gear shaft of the front walking gear 31 is fixedly connected with the first left arm support 115 and the first right arm support 125, a gear shaft of the rear walking gear 32 is fixedly connected with the second left arm support and the second right arm support, as shown in fig. 2, the front walking gear 31 is meshed with the tooth path rack 33, and the rear walking gear 32 is meshed with the tooth path rack 33. As shown in fig. 4, one end of a front bracket 312 is fixedly connected to a gear bearing of the front walking gear 31, a front slider 311 is fixedly connected to the other end of the front bracket 312, a rack runner 34 is fixedly installed on the thermostatic bath 5, the front slider 311 is located in the rack runner 34, as shown in fig. 1, the rear slider 321 is slidably connected to the rack runner 34, the front slider 311 and the rear slider 321 have the same sliding relationship with the rack runner 34, as shown in fig. 3, the length direction of the rack runner 34 is the same as the length direction of the rack 33, so that the relative position of the first fixing clip assembly 1 is maintained above the front walking gear 31, as shown in fig. 4, the contact position of the front slider 311 on the front bracket 312 is convex, as shown in fig. 3, the front slider 311 does not disengage from the rack tooth groove when sliding in the rack runner, as shown in fig. 4, the two front sliders 311 are located on both sides of the front walking gear 31, and the two rack runners 34 corresponding to the front slider 311 are also provided, the first fixing clamp assembly 1 slides along the horizontal direction, so that the chromatographic column to be tested clamped above is kept stable. As shown in fig. 4, the rear traveling gear 32 corresponding to the second fixing clip assembly 2 is identical to the front traveling gear 31, and the structure and principle of the first fixing clip assembly 1 are the same, which are not described herein again. Above-mentioned structure makes first fixation clamp subassembly 1 and second fixation clamp subassembly 2 all can steadily move on tooth track rack 33, realizes the function of adjusting two fixation clamp subassembly intervals, reaches the effect that remains stable when the chromatographic column that awaits measuring that centre gripping length is different.

As shown in fig. 3, the synchronous rotating rod 4 includes a first rotating rod 41 and a second rotating rod 42, a shaft of a first left arm left wheel 113 in the first fixing clamp assembly 1 is fixedly connected to the first rotating rod 41, a shaft of a second left arm left wheel in the second fixing clamp assembly 2 is fixedly connected to the second rotating rod 42, as shown in fig. 4, a connecting portion of the first rotating rod 41 and the second rotating rod 42 is provided with a spline, the first rotating rod 41 is provided with an internal spline tooth, the second rotating rod 42 is provided with an external spline tooth, two sets of spline teeth are matched to enable the first rotating rod 41 and the second rotating rod 42 to synchronously transmit, the first rotating rod 41 is sleeved outside the second rotating rod 42, the internal spline tooth of the first rotating rod 41 is engaged with the external spline tooth of the second rotating rod 42, and synchronous rotation of the first rotating rod 41 and the second rotating rod 42 can be achieved while the length is extended. The second rotating rod 42 is fixedly connected to the second left arm left wheel of the second fixing clip assembly 2, and the internal transmission principle of the second fixing clip assembly 2 is the same as that of the first fixing clip assembly 1, which is not described herein again. When the staff rotated helping hand handle 6, first fixed clamp subassembly 1 and second fixed clamp subassembly 2 changed left and right arms structure in step and press from both sides and get the interval, the even effect of atress when reaching the tight different chromatographic columns of clamp.

As shown in fig. 1, the surface of the power-assisted handle 6 is provided with an anti-slip protrusion 61, and the anti-slip protrusion 61 increases the friction between the hand of the worker and the power-assisted handle 6, so as to realize the function of rotating the power-assisted handle 6 more conveniently.

As shown in fig. 1, a first left anti-slip pad 1121 is fixedly connected to a surface of the first left protruding plate 112 contacting the chromatographic column to be tested, as shown in fig. 4, a first right anti-slip pad 1221 is arranged on a surface of the first right protruding plate 122 contacting the chromatographic column to be tested, so that a second left anti-slip pad is arranged on a surface of the second left protruding plate contacting the chromatographic column to be tested, and a second right anti-slip pad is arranged on a surface of the second right protruding plate contacting the chromatographic column to be tested, because the second fixing clamp assembly 2 has the same structure as the first fixing clamp assembly 1, the second left anti-slip pad and the second right anti-slip pad are not shown in the drawing, the friction between the above anti-slip pads and the contact surface of the chromatographic column to be tested is increased, the chromatographic column to be tested is prevented from sliding, and the effect of stably clamping the chromatographic column to be tested is achieved.

The accuracy grades of the rack 33, the front walking gear 31 and the rear walking gear 32 reach DIN5 grade, so that the accurate distance displacement of the first fixed clamp assembly 1 and the second fixed clamp assembly 2 is realized, the front walking gear 31 moves by one tooth pitch to be a unit distance, the higher the accuracy of the rack 33 is, the smaller the tooth pitch is, the smaller the unit distance is, as shown in FIG. 4, the accuracy grades of the first left gear 116, the first right gear 126 and the second left gear and the second right gear which are not marked in the drawing reach DIN4 grade, DIN represents the accuracy of the accurate gear rack established by the German industry standardization Association, and the gear rack with the accuracy is used for realizing the function of clamping the high-accuracy variation of the range of the chromatographic column to be tested.

In specific implementation, a worker rotates the power-assisted handle 6 to synchronously change the gap distance between the left arm structures and the right arm structures of the first fixing clamp assembly 1 and the second fixing clamp assembly 2, so that chromatographic columns with different diameters are clamped to prevent the chromatographic columns to be tested from being damaged due to uneven stress; the staff adjusts the relative position of first fixation clamp subassembly 1 and second fixation clamp subassembly 2 on tooth way rack 33, changes two relative distances of pressing from both sides the chromatographic column of getting to be measured to press from both sides the chromatographic column of getting different length, realize the function of steadily pressing from both sides tight to different model chromatographic columns.

Above technical characteristics constitute the utility model discloses a best embodiment, it has stronger adaptability and best implementation effect, can increase and decrease unnecessary technical characteristics according to actual need, satisfies the needs of different situation.

It should be finally noted that the above only serves to illustrate the technical solution of the present invention, and not to limit the scope of the present invention, and that simple modifications or equivalent replacements performed by those skilled in the art to the technical solution of the present invention do not depart from the spirit and scope of the technical solution of the present invention.

Claims

1. A convenient-to-use high performance liquid chromatograph for producing oseltamivir comprises a constant temperature bath (5), and is characterized in that: a fixing clamp assembly, a synchronous rotating rod (4) and a power-assisted handle (6) are arranged in the thermostatic bath (5), the fixing clamp assembly comprises a first fixing clamp assembly (1) and a second fixing clamp assembly (2), the first fixing clamp assembly (1) comprises a first left arm structure (11) and a first right arm structure (12), the first left arm structure (11) comprises a first left conveyor belt (111), a first left convex plate (112), a first left arm left wheel (113), a first left arm right wheel (114), a first left arm support (115) and a first left gear (116), the first left arm left wheel (113) and the first left arm right wheel (114) are connected through the first left conveyor belt (111), a bearing of the first left arm left wheel (113), a bearing of the first left arm right wheel (114) and a bearing of the first left gear (116) are respectively and fixedly connected to the first left arm support (115), the first left conveyor belt (111) is fixedly connected with the first left convex plate (112); the first right arm structure (12) comprises a first right conveyor belt (121), a first right convex plate (122), a first right arm left wheel, a first right arm right wheel (124), a first right arm support (125) and a first right gear (126), the first right arm left wheel and the first right arm right wheel (124) are connected through the first right conveyor belt (121), a bearing of the first right arm left wheel, a bearing of the first right arm right wheel (124) and a bearing of the first right gear (126) are fixedly connected to the first right arm support (125) respectively, and the first right convex plate (122) is fixedly connected to the first right conveyor belt (121); the first left arm bracket (115) and the first right arm bracket (125) are fixedly connected to the thermostatic bath (5), and the first left gear (116) and the first right gear (126) are meshed;

the second fixing clamp component (2) has the same structure as the first fixing clamp component (1); synchronous dwang (4) are arranged in making in first fixed clamp subassembly (1) first left arm left wheel (113) with second left arm left wheel synchronous rotation in the second fixed clamp subassembly (2), helping hand handle (6) fixed connection in first left arm left wheel (113) is kept away from on the bearing of synchronous dwang (4).

2. The easy-to-use high performance liquid chromatograph for producing oseltamivir according to claim 1, wherein: a conveyor belt gap is formed between the first left conveyor belt (111) and the first right conveyor belt (121), and a first pallet (14) is placed on the conveyor belt gap and is in sliding connection with the first left conveyor belt (111) and the first right conveyor belt (121); a conveyor belt gap is formed between the second left conveyor belt and the second right conveyor belt, a second saddle (24) is placed on the conveyor belt gap, and the second saddle (24) is in sliding connection with the second left conveyor belt and the second right conveyor belt respectively.

3. The easy-to-use high performance liquid chromatograph for producing oseltamivir according to claim 2, wherein: a first flat anti-skid pad (141) is arranged on the upper surface of the first pallet (14); and a second flat anti-skid pad is arranged on the upper surface of the second saddle (24).

4. The easy-to-use high performance liquid chromatograph for producing oseltamivir according to claim 1, wherein: constant temperature bath (5) be provided with tooth way subassembly (3), tooth way subassembly (3) are including preceding walking gear (31), back walking gear (32) and tooth way rack (33), first fixed clamp subassembly (1) fixed connection in preceding walking gear (31) bearing, second fixed clamp subassembly (2) fixed connection in back walking gear (32) bearing, preceding walking gear (31) with back walking gear (32) with tooth way rack (33) meshing, the gear shaft fixed connection of preceding walking gear (31) first left arm support (115) with first right arm support (125), the gear shaft fixed connection of back walking gear (32) in second left arm support and second right arm support.

5. The easy-to-use high performance liquid chromatograph for producing oseltamivir according to claim 4, wherein: the bearing of the gear shaft of the front walking gear (31) is fixedly connected with one end of a front support (312), the other end of the front support (312) is fixedly connected with a front sliding block (311), the thermostatic bath (5) is fixedly provided with a tooth path sliding chute (34), the front sliding block (311) is positioned in the tooth path sliding chute (34), the front sliding block (311) is in sliding connection with the tooth path sliding chute (34), and the length direction of the tooth path sliding chute (34) is the same as that of the tooth path rack (33); the bearing of back walking gear (32) gear shaft fixedly connected with one end of after-poppet (322), the other end fixedly connected with back slider (321) of after-poppet (322), back slider (321) are located in tooth way spout (34), back slider (321) with tooth way spout (34) sliding connection.

6. The easy-to-use high performance liquid chromatograph for producing oseltamivir according to claim 5, wherein: the number of the front sliding blocks (311) is two, the number of the rear sliding blocks (321) is two, and the number of the tooth track sliding grooves (34) corresponding to the front sliding blocks (311) is two.

7. The easy-to-use high performance liquid chromatograph for producing oseltamivir according to claim 1, wherein: synchronous dwang (4) include first bull stick (41) and second bull stick (42), first bull stick (41) fixed connection in the epaxial of first left arm left wheel (113), second bull stick (42) fixed connection in the epaxial of second left arm left wheel, first bull stick (41) with the junction of second bull stick (42) is provided with the spline.

8. The easy-to-use high performance liquid chromatograph for producing oseltamivir according to claim 1, wherein: the surface of the power-assisted handle (6) is provided with an anti-skid bulge (61).

9. The easy-to-use high performance liquid chromatograph for producing oseltamivir according to claim 1, wherein: the face that first left flange (112) contact chromatographic column that awaits measuring is provided with first left slipmat (1121), the face that first right flange (122) contact chromatographic column that awaits measuring is provided with first right slipmat (1221), the face that the left flange contact chromatographic column that awaits measuring of second is provided with the left slipmat of second, and the face that the right flange contact chromatographic column that awaits measuring of second is provided with the right slipmat of second.

10. The easy-to-use high performance liquid chromatograph for producing oseltamivir according to claim 5, wherein: the precision grades of the rack (33), the front walking gear (31) and the rear walking gear (32) reach DIN5 grade.

11. The easy-to-use high performance liquid chromatograph for producing oseltamivir according to claim 1, wherein: the precision grades of the first left gear (116), the first right gear (126), the second left gear and the second right gear reach DIN4 grade.