CN115217750A - Calibration device for infusion pump in liquid chromatograph - Google Patents
Calibration device for infusion pump in liquid chromatograph Download PDFInfo
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- CN115217750A CN115217750A CN202210628951.8A CN202210628951A CN115217750A CN 115217750 A CN115217750 A CN 115217750A CN 202210628951 A CN202210628951 A CN 202210628951A CN 115217750 A CN115217750 A CN 115217750A
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- 239000007788 liquid Substances 0.000 title claims abstract description 223
- 238000001802 infusion Methods 0.000 title claims abstract description 25
- 239000002699 waste material Substances 0.000 claims abstract description 72
- 238000005303 weighing Methods 0.000 claims abstract description 15
- 238000000034 method Methods 0.000 claims abstract description 8
- 230000007246 mechanism Effects 0.000 claims abstract description 5
- 238000007789 sealing Methods 0.000 claims description 9
- 238000012546 transfer Methods 0.000 claims description 7
- 230000005540 biological transmission Effects 0.000 claims description 3
- 230000008569 process Effects 0.000 abstract description 4
- 230000008859 change Effects 0.000 description 4
- 230000033228 biological regulation Effects 0.000 description 2
- 238000012545 processing Methods 0.000 description 2
- 230000009467 reduction Effects 0.000 description 2
- 238000000926 separation method Methods 0.000 description 2
- 231100000419 toxicity Toxicity 0.000 description 2
- 230000001988 toxicity Effects 0.000 description 2
- 230000005526 G1 to G0 transition Effects 0.000 description 1
- 239000005409 aflatoxin Substances 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 238000003912 environmental pollution Methods 0.000 description 1
- 230000005484 gravity Effects 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 230000000149 penetrating effect Effects 0.000 description 1
- 238000004451 qualitative analysis Methods 0.000 description 1
- 238000004445 quantitative analysis Methods 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 238000001179 sorption measurement Methods 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 238000002627 tracheal intubation Methods 0.000 description 1
- 238000012795 verification Methods 0.000 description 1
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- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F04—POSITIVE - DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS FOR LIQUIDS OR ELASTIC FLUIDS
- F04B—POSITIVE-DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS
- F04B51/00—Testing machines, pumps, or pumping installations
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
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Abstract
The invention relates to a calibration device of an infusion pump in a liquid chromatograph, which comprises a calibration support, wherein a rotary table driven by a power mechanism is rotatably assembled on the calibration support, metering bottles and waste liquid bottles are arranged on the rotary table at intervals along the circumferential direction, a weighing sensor is arranged on the rotary table at the lower side of the metering bottles, the rotating axis of the rotary table is arranged in an up-and-down extending manner, a liquid through pipe with the upper end used for being connected with a waste liquid pipe of the liquid chromatograph is arranged on the upper side of the metering bottles on the calibration support, a first station enabling an upper end bottle opening of the metering bottles to correspond to a liquid outlet of the liquid through pipe and a second station enabling an upper end bottle opening of the waste liquid bottles to correspond to a liquid outlet of the liquid through pipe are arranged in the rotating process of the rotary table, and the calibration device further comprises a timing unit connected with the weighing sensor. The invention solves the technical problem of high labor intensity caused by manual timing when the flow of the infusion pump is calibrated in the prior art.
Description
Technical Field
The invention relates to the field of metering calibration, in particular to a calibration device for an infusion pump in a liquid chromatograph.
Background
The liquid chromatograph is an analytical instrument consisting of a liquid conveying system, a sample introduction system, a separation system, a detection system, a data processing system and the like. The liquid chromatograph carries the sample into the chromatographic column by the mobile phase for separation according to the difference of the stationary phase and the mobile phase distribution or adsorption and other characteristics of each component in the sample in the chromatographic column, the sample is detected by a detector and the chromatogram is recorded by a data processing system, and qualitative and quantitative analysis is carried out according to the retention time and the response value of each component.
The power source in the liquid conveying system in the liquid chromatograph is an infusion pump, and the following items in the liquid chromatograph need to be checked and calibrated periodically according to the regulation in the JJJG 705-2014 liquid chromatograph verification regulation, wherein the items needing to be checked and calibrated comprise the flow rate of the infusion pump, the temperature of a column oven, the baseline noise of a detector, baseline drift and the like.
In the prior art, the flow of the infusion pump needs to be calibrated firstly, and the specific calibration process is that a waste liquid tube of a liquid chromatograph is pulled out from a waste liquid bottle, then the waste liquid tube is manually inserted into a measuring bottle, a manual stopwatch is used for timing, and after a certain time, the weight or the volume of the waste liquid in the measuring bottle is weighed, so that the flow of the infusion pump is obtained; and then, carrying out subsequent calibration of other items under the same flow rate in the state that the infusion pump cannot be shut down.
In the prior art, the flow is calculated by means of intubation, manual tube drawing and manual timing, so that the method is time-consuming and labor-consuming, and inaccurate calculated data is easily caused. In addition, the waste liquid generated by detecting some special materials is toxic, for example, when the liquid chromatography-aflatoxin is used for detecting, the waste liquid contains toxicity, and the manual operation mode is easy to cause the problem that the waste liquid volatilizes to cause toxicity to the environment.
Disclosure of Invention
The invention aims to provide a calibration device for an infusion pump in a liquid chromatograph, which aims to solve the technical problem of high labor intensity caused by manual timing when the flow of the infusion pump is calibrated in the prior art.
In order to solve the technical problems, the technical scheme of the calibration device for the infusion pump in the liquid chromatograph is as follows:
calibration device of transfer pump in liquid chromatograph, including the calibration support, it is equipped with by power unit driven carousel to rotate on the calibration support, be provided with measuring flask and waste liquid bottle along circumference interval on the carousel, be provided with weighing sensor in the downside of measuring flask on the carousel, the axis of rotation of carousel extends the setting along upper and lower direction, be provided with the liquid pipe that leads to that the upper end is used for linking to each other with liquid chromatograph's waste liquid pipe on the calibration support in the upside of measuring flask, the carousel rotates the in-process and has the first station that makes the upper end bottleneck of measuring flask and the liquid outlet that leads to the liquid pipe correspond and the second station that makes the upper end bottleneck of waste liquid bottle and the liquid outlet that leads to the liquid pipe correspond.
The beneficial effects of the invention are as follows: when the calibrating device is used for calibrating an infusion pump in a liquid chromatograph, a waste liquid pipe of the liquid chromatograph is inserted into the upper end of a liquid through pipe, waste liquid flows to a metering bottle through the liquid through pipe, when a weighing sensor senses that weight begins to change, a timing unit automatically counts time, flow is calculated according to timing of the timing unit and weighing change of the weighing sensor, so that the infusion pump is calibrated, after calibration is finished, a rotating disc rotates, the rotating disc rotates from a first station to a second station, waste liquid flows to a waste liquid bottle through the liquid through pipe, manual operation is not needed, and other items of the liquid chromatograph can be calibrated continuously.
Furthermore, the calibration support comprises a support base, a vertically arranged fixing shaft is fixed on the support base, and the rotary table is rotatably assembled on the fixing shaft.
Furthermore, a rotating sleeve sleeved on the periphery of the fixed shaft is connected to the rotating disc, a rotating sleeve gear is arranged on the rotating sleeve, the power mechanism comprises a speed reducing motor arranged on the support base, and a motor shaft gear meshed with the rotating sleeve gear for transmission is fixed on a motor shaft of the speed reducing motor.
Furthermore, be provided with on the fixed axle along the radial liquid pipe bracket arm that extends of fixed axle, the one end that the fixed axle was kept away from to liquid pipe bracket arm is provided with the liquid pipe clamp that leads to, leads to the liquid pipe and connects on the liquid pipe clamp.
Furthermore, a fixed disc located between the liquid flowing pipe and the measuring bottle is fixed on the fixed shaft, a fixed disc through hole penetrating through the fixed disc in the up-down direction is formed in the fixed disc, the fixed disc through hole is used for communicating the liquid outlet of the liquid flowing pipe with the upper end bottle opening of the measuring bottle or the liquid outlet of the liquid flowing pipe with the upper end bottle opening of the waste liquid bottle, and the upper end portion of the measuring bottle and the bottom of the fixed disc are in sealed sliding fit.
Furthermore, the fixed disc comprises a rigid plate, a rubber plate is fixed at the lower end of the rigid plate, and the upper end parts of the metering bottle and the waste liquid bottle are in sealing sliding fit with the lower plate surface of the rubber plate.
Furthermore, the height of the fixed disc can be adjusted up and down.
Furthermore, the upper ends of the metering bottle and the waste liquid bottle are fixed with an annular liquid guide groove, the section of the annular liquid guide groove is in a U shape with an open upper end, a groove cavity of the annular liquid guide groove corresponds to the through hole of the fixed disc, the upper end of the annular liquid guide groove is in sliding seal fit with the bottom of the fixed disc, the metering bottle and the waste liquid bottle divide the annular liquid guide groove into a first arc-shaped liquid guide groove section and a second arc-shaped liquid guide groove section which are independently arranged relative to each other, the upper end of the metering bottle is provided with a metering bottle inlet communicated with the first arc-shaped liquid guide groove section, and the upper end of the waste liquid bottle is provided with a waste liquid bottle inlet communicated with the second arc-shaped liquid guide groove section.
Further, the height of the bottom of the second arc-shaped liquid guide groove section is gradually reduced from the metering bottle to the liquid inlet of the waste liquid bottle; from the waste liquid bottle to the liquid inlet of the metering bottle, the height of the groove bottom of the first arc-shaped liquid guide groove section is gradually reduced.
Drawings
The above and other objects, features and advantages of exemplary embodiments of the present disclosure will become readily apparent from the following detailed description, which proceeds with reference to the accompanying drawings. Several embodiments of the present disclosure are illustrated by way of example, and not by way of limitation, in the figures of the accompanying drawings and in which like reference numerals refer to like or corresponding parts and in which:
fig. 1 is a schematic structural view of an embodiment of a calibration apparatus for an infusion pump in a liquid chromatograph according to the present invention;
FIG. 2 is an enlarged view at A in FIG. 1;
FIG. 3 is a schematic view of the combination of the measuring flask and the flask-holding bracket of FIG. 1;
FIG. 4 is a schematic view of the combination of the measuring flask, the waste liquid bottle and the annular liquid guiding groove in FIG. 1;
FIG. 5 is an enlarged view at B in FIG. 4;
description of the reference numerals: 1. a base leg; 2. a support base; 3. rotating the sleeve gear; 4. rotating the sleeve; 5. a turntable; 6. a waste liquid bottle; 7. fixing the disc; 8. fixing the disc; 9. an annular liquid guide groove; 10. a fixed shaft; 11. a liquid pipe bracket arm; 12. a liquid pipe clamp is arranged; 13. a waste liquid pipe; 14. a liquid through pipe; 15. a metering bottle; 16. a bottle limiting bracket; 17. a motor shaft gear; 18. a reduction motor; 19. a weighing sensor; 20. a limiting bracket supporting leg; 21. a screw; 22. a limiting block; 23. a rigid plate; 24. a rubber plate; 25. a through hole of the fixed disc; 26. a liquid inlet of the measuring bottle; 27. the upper end of the metering bottle is provided with a bottle mouth; 28. a first arc-shaped drain tank section; 29. a second arc-shaped drain tank section; 30. the upper end of the waste liquid bottle is provided with a bottle mouth; 31. a liquid inlet hole of the waste liquid bottle; 32. adjusting the nut; 33. a telescopic supporting rod.
Detailed Description
In order to facilitate an understanding of the invention, reference will now be made in detail to the present embodiments of the invention, examples of which are illustrated in the accompanying drawings. Preferred embodiments of the present invention are shown in the drawings. The invention may, however, be embodied in many different forms and should not be construed as limited to the embodiments set forth herein. Rather, these embodiments are provided so that this disclosure will be thorough and complete.
It is to be noted that, unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs. The terminology used in the description of the invention herein is for the purpose of describing particular embodiments only and is not intended to be limiting of the invention.
Fig. 1 to 5 show examples of a calibration device for an infusion pump in a liquid chromatograph according to the present invention: including the calibration support, the calibration support includes support base 2, and the bottom of support base is fixed with base landing leg 1, and the intermediate position of support base 2 is fixed with the fixed axle 10 that the axis extends along upper and lower direction.
The fixed shaft 10 is rotatably assembled with a rotating disc 5 driven by a power mechanism, in this embodiment, the lower end of the rotating disc 5 is fixedly connected with a rotating sleeve 4 sleeved on the periphery of the fixed shaft, a rotating sleeve gear 3 is fixed on the rotating sleeve 4, the power mechanism includes a gear motor 18 arranged on the base of the bracket, and a motor shaft gear 17 meshed with the rotating sleeve gear for transmission is fixed on a motor shaft of the gear motor 18.
The metering bottle 15 and the waste liquid bottle 6 are arranged on the rotary table at intervals along the circumferential direction, in the embodiment, the metering bottle 15 and the waste liquid bottle 6 are symmetrically arranged by taking the fixed shaft as a center, the metering bottle and the waste liquid bottle are both in a conical structure with a small top and a big bottom, the weighing sensor 19 is arranged on the rotary table at the lower side of the metering bottle, and the metering bottle is placed on the weighing sensor.
The rotary table is provided with bottle limiting supports 16 used for limiting the movement of the metering bottles and the waste liquid bottles, each bottle limiting support 16 comprises two limiting support legs 20 which are arranged at intervals, each limiting support leg 20 is fixed with a limiting block 22 through a screw 21, and each limiting block 22 is provided with a conical limiting surface matched with the periphery of the corresponding bottle in a conical manner. Two stoppers of each bottle spacing support are independently arranged along corresponding bottle circumference interval, can arrange the measuring flask in during use in between the spacing landing leg that corresponds earlier, then screwed connection stopper on the spacing landing leg that corresponds to restriction measuring flask relative carousel removes.
The upper end of the calibration support is provided with a liquid through pipe 14 connected with a waste liquid pipe of the liquid chromatograph, the turntable rotates to enable a first station corresponding to an upper end bottle opening 27 of the metering bottle and a liquid outlet of the liquid through pipe and a second station corresponding to an upper end bottle opening 30 of the waste liquid bottle and a liquid outlet of the liquid through pipe in the process, and the calibration device further comprises a timing unit connected with the weighing sensor.
In this embodiment, a liquid pipe bracket arm 11 extending along the radial direction of the fixed shaft is fixed on the fixed shaft, a liquid pipe clamp 12 is arranged at one end of the liquid pipe bracket arm far away from the fixed shaft, and a liquid pipe 14 is connected on the liquid pipe clamp 12. When in use, the waste liquid pipe 13 of the liquid chromatograph is plugged at the upper end of the liquid through pipe through a rubber bottle plug.
The fixed shaft is provided with a fixed disc 8 positioned between the liquid through pipe and the measuring bottle, and the fixed disc 8 is also positioned between the liquid through pipe 14 and the waste liquid bottle 6. The fixed disk is provided with a fixed disk through hole 25 which penetrates through the fixed disk along the vertical direction, the lower end of the liquid through pipe 14 extends into the fixed disk through hole 25, and a sealing ring is arranged between the periphery of the liquid through pipe 14 and the fixed disk through hole.
The fixed disc comprises a rigid plate 23, a rubber plate 24 is fixed at the lower end of the rigid plate 23, the through hole of the fixed disc penetrates through the rigid plate and the rubber plate, and the upper end parts of the metering bottle and the waste liquid bottle are in sealing sliding fit with the lower plate surface of the rubber plate.
The fixed shaft is in threaded connection with adjusting nuts 32 on the upper side and the lower side of the fixed disc, and the height of the fixed disc can be adjusted by changing the positions of the adjusting nuts.
The upper ends of the metering bottle and the waste liquid bottle are fixed with an annular liquid guide groove 9, the groove bottom of the specific annular liquid guide groove is sleeved at the upper ends of the metering bottle and the waste liquid bottle, the section shape of the annular liquid guide groove is a U shape with an open upper end, a groove cavity of the annular liquid guide groove corresponds to a through hole of the fixed disc, the upper end of the annular liquid guide groove is in sliding sealing fit with the bottom of the fixed disc, the metering bottle and the waste liquid bottle divide the annular liquid guide groove into a first arc-shaped liquid guide groove section 28 and a second arc-shaped liquid guide groove section 29 which are independently arranged relative to each other, the side wall of the upper end of the metering bottle is provided with a metering bottle inlet 26 communicated with the first arc-shaped liquid guide groove section 28, and the side wall of the upper end of the waste liquid bottle is provided with a waste liquid bottle inlet 31 communicated with the second arc-shaped liquid guide groove section. In order to ensure the stability of the annular liquid guide groove, a telescopic supporting rod 33 with adjustable height is arranged between the rotary table and the bottom of the annular liquid guide groove, the bottom of the telescopic supporting rod is fixed on the rotary table, and the upper end of the telescopic supporting rod 33 is matched with the bottom support of the annular liquid guide groove. The widths of the first arc-shaped groove section and the second arc-shaped groove section are not smaller than the diameter of the through hole of the fixed disc.
The height of the bottom of the second arc-shaped liquid guide groove section is gradually reduced from the metering bottle to the liquid inlet of the waste liquid bottle; from the waste liquid bottle to the direction of the liquid inlet of the metering bottle, the height of the groove bottom of the first arc-shaped liquid guide groove section is gradually reduced.
In use, the gear motor may drive the turntable to rotate counterclockwise as viewed in fig. 4. When the device is used, the metering bottle and the waste liquid bottle are placed on the rotary table, then the bottle limiting support is fixed, and the height of the rotary table is adjusted again, so that the upper end of the metering bottle is in sealing fit with the rubber plate, the upper end of the waste liquid bottle is in sealing fit with the rubber plate, and the upper ends of the first arc-shaped liquid guide groove section and the second arc-shaped liquid guide groove section are in sealing fit with the rubber plate. The carousel rotates to first station, the upper end bottleneck of measuring flask passes through the fixed disk through-hole and leads to liquid pipe lower extreme intercommunication, weighing sensor returns to zero, weighing sensor's the button that returns to zero can be realized through setting up, be connected liquid chromatograph's waste liquid pipe and the upper end of leading to liquid pipe, when the waste liquid enters into the measuring flask, the gravity change is sensed to the measuring flask, give a signal of timing unit, the timing unit begins the timing, say after timing a minute, can accurately calculate the pump sending flow of transfer pump according to the weight change of measuring flask.
After the transfer pump is calibrated, the speed reduction motor drives the rotary table to rotate anticlockwise, the rotary table rotates from the first station to the second station, in the process, the upper end bottleneck of the metering bottle can rotate away from the fixed disc through hole, the second arc-shaped liquid guide groove section is connected with the liquid through pipe through the fixed disc through hole, at the moment, the liquid through pipe cannot be stopped because the transfer pump, waste liquid flows downwards continuously, the waste liquid can enter the second arc-shaped liquid guide groove section, the waste liquid is prevented from being lost and causing environmental pollution, the waste liquid enters the waste liquid bottle through the second arc-shaped liquid guide groove section and the liquid inlet hole of the waste liquid bottle, when the rotary table rotates to the second station, the upper end bottleneck of the waste liquid bottle is connected with the liquid through pipe through the fixed disc through hole, at the moment, the waste liquid in the liquid through pipe can directly enter the waste liquid bottle, and the implementation of other calibration items is guaranteed.
If need carry out recalibration to the transfer pump, then can rotate to first station by the second station through gear motor drive carousel, this in-process, the waste liquid can be through first arc drain chute section, during the measuring flask inlet enters into the measuring flask, when the carousel rotated to first station, weighing sensor return to zero, and the timing unit begins the timing simultaneously, carries out recalibration once more to the transfer pump.
In the above description of the present specification, the terms "fixed," "mounted," "connected," or "connected," and the like, are to be construed broadly unless otherwise expressly specified or limited. For example, with the term "coupled", it can be fixedly coupled, detachably coupled, or integrally formed; can be mechanically or electrically connected; they may be directly connected or indirectly connected through intervening media, or they may be connected internally or in any other suitable relationship. Therefore, unless otherwise specifically defined in the present specification, the specific meanings of the above-mentioned terms in the present invention can be understood by those skilled in the art according to specific situations.
In light of the foregoing description of the present specification, those skilled in the art will also understand that terms used herein, such as "upper," "lower," "front," "rear," "left," "right," "length," "width," "thickness," "vertical," "horizontal," "top," "bottom," "inner," "outer," "axial," "radial," "circumferential," "center," "longitudinal," "lateral," "clockwise," or "counterclockwise," etc., indicate that such terms are based on the orientations and positional relationships illustrated in the drawings of the present specification, and are intended merely to facilitate explanation of the invention and to simplify the description, but do not indicate or imply that the device or element involved must have the particular orientation, be constructed and operated in the particular orientation, and therefore such terms are not to be understood or interpreted as limiting the scope of the present invention.
In addition, the terms "first" or "second", etc. used in this specification are used to refer to numbers or ordinal terms for descriptive purposes only and are not to be construed as indicating or implying relative importance or implicitly indicating the number of technical features indicated. Thus, a feature defined as "first" or "second" may explicitly or implicitly include at least one of the feature. In the description of the present specification, "a plurality" means at least two, for example, two, three or more, and the like, unless specifically defined otherwise.
Finally, it should be noted that: the above examples are only intended to illustrate the technical solution of the present invention, but not to limit it; although the present invention has been described in detail with reference to the foregoing embodiments, it will be understood by those of ordinary skill in the art that: the technical solutions described in the foregoing embodiments may still be modified, or some technical features may be equivalently replaced; and such modifications or substitutions do not depart from the spirit and scope of the corresponding technical solutions of the embodiments of the present invention.
Claims (9)
1. The calibrating device of transfer pump among liquid chromatograph, its characterized in that: including the calibration support, it is equipped with by power unit driven carousel to rotate on the calibration support, be provided with measuring flask and waste liquid bottle along circumference interval on the carousel, be provided with weighing sensor in the downside of measuring flask on the carousel, the axis of rotation of carousel extends the setting along upper and lower direction, be provided with the logical liquid pipe that the upper end is used for linking to each other with liquid chromatograph's waste liquid pipe on the calibration support in the upside of measuring flask, the carousel rotates the in-process and has the first station that makes the upper end bottleneck of measuring flask and the liquid outlet that leads to the liquid pipe correspond and the second station that makes the upper end bottleneck of waste liquid bottle and the liquid outlet that leads to the liquid pipe correspond, calibrating device still includes the timing unit that links to each other with weighing sensor.
2. The calibration device for an infusion pump in a liquid chromatograph according to claim 1, wherein: the calibration support comprises a support base, a vertically arranged fixed shaft is fixed on the support base, and the rotary table is rotatably assembled on the fixed shaft.
3. The apparatus for calibrating an infusion pump in a liquid chromatograph according to claim 2, wherein: the rotating sleeve sleeved on the periphery of the fixed shaft is connected to the rotating disc, a rotating sleeve gear is arranged on the rotating sleeve, the power mechanism comprises a speed reducing motor arranged on the support base, and a motor shaft gear meshed with the rotating sleeve gear for transmission is fixed on a motor shaft of the speed reducing motor.
4. The apparatus for calibrating an infusion pump in a liquid chromatograph according to claim 2, wherein: be fixed with on the fixed axle along the liquid pipe bracket arm that leads to of fixed axle radial extension, the one end that leads to the liquid pipe bracket arm and keep away from the fixed axle is provided with leads to the liquid pipe clamp, leads to the liquid pipe and connects on leading to the liquid pipe clamp.
5. The apparatus for calibrating an infusion pump in a liquid chromatograph according to claim 2, wherein: the fixed shaft is provided with a fixed disc positioned between the liquid through pipe and the metering bottle, the fixed disc is provided with a fixed disc through hole which penetrates through the fixed disc along the up-down direction, the fixed disc through hole is used for communicating the liquid outlet of the liquid through pipe with the upper end bottle opening of the metering bottle or the liquid outlet of the liquid through pipe with the upper end bottle opening of the waste liquid bottle, and the upper end parts of the metering bottle and the waste liquid bottle are in sealed sliding fit with the bottom of the fixed disc.
6. The apparatus for calibrating an infusion pump in a liquid chromatograph according to claim 5, wherein: the fixed disc comprises a rigid plate, a rubber plate is fixed at the lower end of the rigid plate, and the upper end parts of the metering bottle and the waste liquid bottle are in sealing sliding fit with the lower plate surface of the rubber plate.
7. The calibration device for an infusion pump in a liquid chromatograph according to claim 5, wherein: the height of the fixed disk is adjustable.
8. The calibration device for an infusion pump in a liquid chromatograph according to claim 5, wherein: the upper end of the measuring bottle and the waste liquid bottle is fixed with an annular liquid guide groove, the section of the annular liquid guide groove is in a U shape with an open upper end, a groove cavity of the annular liquid guide groove corresponds to the through hole of the fixed disc, the upper end of the annular liquid guide groove is matched with the bottom of the fixed disc in a sliding and sealing manner, the measuring bottle and the waste liquid bottle divide the annular liquid guide groove into a first arc-shaped liquid guide groove section and a second arc-shaped liquid guide groove section which are mutually and independently arranged, the side wall of the upper end of the measuring bottle is provided with a measuring bottle inlet communicated with the first arc-shaped liquid guide groove section, and the side wall of the upper end of the waste liquid bottle is provided with a waste liquid bottle inlet communicated with the second arc-shaped liquid guide groove section.
9. The calibration device for an infusion pump in a liquid chromatograph according to claim 8, wherein: the height of the bottom of the second arc-shaped liquid guide groove section is gradually reduced from the metering bottle to the liquid inlet of the waste liquid bottle; from the waste liquid bottle to the liquid inlet of the metering bottle, the height of the groove bottom of the first arc-shaped liquid guide groove section is gradually reduced.
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| CN202210628951.8A CN115217750B (en) | 2022-06-06 | 2022-06-06 | Calibrating device for infusion pump in liquid chromatograph |
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| CN202210628951.8A CN115217750B (en) | 2022-06-06 | 2022-06-06 | Calibrating device for infusion pump in liquid chromatograph |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN116242440A (en) * | 2023-05-04 | 2023-06-09 | 江苏省计量科学研究院(江苏省能源计量数据中心) | Flow calibration method and system for liquid chromatograph infusion system |
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| CN116242440B (en) * | 2023-05-04 | 2023-09-29 | 江苏省计量科学研究院(江苏省能源计量数据中心) | Flow calibration method and system for liquid chromatograph infusion system |
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