CN213726600U

CN213726600U - Solvent preparation system

Info

Publication number: CN213726600U
Application number: CN202021390971.9U
Authority: CN
Inventors: 李定中; 宋水军; 姚鹏志
Original assignee: Lufen Apparatus Zhenjiang Co ltd
Current assignee: Lufen Apparatus Zhenjiang Co ltd; Logan Instruments Corp
Priority date: 2020-07-15
Filing date: 2020-07-15
Publication date: 2021-07-20
Anticipated expiration: 2030-07-15

Abstract

The utility model relates to a solvent preparation system, which comprises a solvent box body, a heating mechanism, a degassing mechanism and a transmission mechanism, wherein the heating mechanism, the degassing mechanism and the transmission mechanism are arranged in the solvent box body; the heating mechanism comprises a circulating water pump, an electric heater and a circulating pipe, the circulating water pump is arranged on one side of the water tank, and the electric heater, the circulating water pump and the water tank are connected through the circulating pipe to form a closed loop; the degassing mechanism comprises a vacuum suction filter, a first suction filter pipe and a second suction filter pipe, the filter and the water tank are connected through the first suction filter pipe to form a closed loop, the air inlet end of the vacuum suction filter is connected with the second suction filter pipe, and one end of the second suction filter pipe is communicated with the inside of the filter. The solvent in the water tank is heated and degassed rapidly and circularly, and the requirement of solvent experiment is met.

Description

Solvent preparation system

Technical Field

The utility model belongs to the technical field of test instrument, concretely relates to menstruum preparation system.

Background

Prior to marketing, drugs need to be tested for the rate and extent of dissolution of the active pharmaceutical ingredient from a formulation such as a tablet, capsule or granule under defined conditions. It is an index for evaluating the quality of oral solid preparation, and the medicine is tested in the physiological environment similar to human body, so that it needs solvent to simulate human body. The menstruum needs to be preheated and deoxidized before being used, in the prior art, the menstruum is heated and deoxidized separately, at least two devices and instruments are needed to work cooperatively, and the test cost is high and the efficiency is low.

SUMMERY OF THE UTILITY MODEL

The utility model discloses to above-mentioned problem, disclose menstruum preparation system, can preheat the menstruum and deoxidate to with menstruum quantitative transmission to dissolving out the cup.

The specific technical scheme is as follows:

the solvent preparation system comprises a solvent box body, and a heating mechanism, a degassing mechanism and a transmission mechanism which are arranged in the solvent box body, wherein the lower end of the solvent box body is provided with a water tank, one side of the top of the water tank is connected with a liquid pumping pipe, the other end of the liquid pumping pipe is connected with a liquid pumping pump, the water inlet end of the liquid pumping pump is connected with a liquid inlet pipe, and the liquid inlet pipe is communicated with the solvent end; the heating mechanism comprises a circulating water pump, an electric heater and a circulating pipe, the electric heater is arranged at the top of the inner wall of the solvent box body, the circulating water pump is arranged on one side of the water tank, and the electric heater, the circulating water pump and the water tank are connected through the circulating pipe to form a closed loop;

the degassing mechanism comprises a vacuum suction filter, a first suction filter pipe and a second suction filter pipe, the filter is arranged on the water tank, the filter and the water tank are connected through the first suction filter pipe to form a closed loop, the vacuum suction filter is arranged at the top of the inner wall of the solvent box body, the air inlet end of the vacuum suction filter is connected with the second suction filter pipe, and one end of the second suction filter pipe is communicated with the inside of the filter;

the transmission mechanism is arranged at the top of the solvent box body and comprises a support, an installation frame, a servo motor, dissolution cups, a first transmission pipe and a second transmission pipe, the support is arranged at the top of the solvent box body, a plurality of support rods and a plurality of dissolution cups are vertically arranged at the top of the support, a plurality of three-way valves are arranged in the support, one end of each three-way valve penetrates through the support and is connected with the bottom of the dissolution cup, two ends of each three-way valve are respectively connected with one first transmission pipe and one second transmission pipe, one end of each first transmission pipe enters the bottom of the water tank, one end of each first transmission pipe close to the three-way valve is provided with a first one-way valve, the other transmission pipes penetrate through the top of the solvent box body and respectively transmit solvents to the dissolution cups, one end of each second transmission pipe close to the three-way valve is provided with a second one-way valve, and the top of each dissolution cup is connected with the installation frame, the mounting rack is arranged on the support through the plurality of support rods, and the plurality of support rods penetrate through the bottom of the mounting rack and are fixedly connected with the top of the mounting rack; a screw rod is vertically arranged in the middle of the mounting frame, a lifting seat is in threaded connection with the screw rod, the lifting seat is penetrated through by a plurality of support rods and is movably connected with the support rods, a plurality of piston rods are vertically arranged around the bottom of the lifting seat, a piston is arranged at the bottom of each piston rod, and the lower end of each piston rod enters each dissolving-out cup respectively; the upper end and the lower end of the screw rod are rotatably connected with rotating seats, the rotating seats are respectively arranged on the inner walls of the upper end and the lower end of the mounting rack, the bottom of the mounting rack is fixedly provided with the servo motor, and the output end of the servo motor penetrates through the rotating seats and is fixedly connected with the bottom end of the screw rod.

Furthermore, a PLC controller is further arranged in the mounting frame and is respectively and electrically connected with the liquid pump, the electric heater, the circulating water pump, the vacuum suction filter and the servo motor through leads.

Furthermore, the number of the dissolution cups is 6, and the 6 dissolution cups are uniformly distributed on the support.

Furthermore, the liquid pumping pipe, the liquid inlet pipe, the circulating pipe, the first suction filter pipe, the second suction filter pipe, the first transmission pipe and the second transmission pipe are all silica gel hoses.

Furthermore, scales are marked on the dissolution cup.

Further, the length of the silk rod is not less than that of the dissolving-out cup.

The utility model has the advantages that:

(1) the utility model discloses an electric heater, circulating water pump and circulating pipe cooperate and carry out quick circulation heating with the menstruum in the water tank, cooperate through vacuum suction filter, first suction filtration pipe and second suction filtration pipe simultaneously, realize degassing fast with the menstruum in the water tank, have satisfied the experimental needs of menstruum.

The utility model discloses can dissolve out the cup simultaneously and carry the menstruum to 6 to the transmission capacity of menstruum can pass through PLC controller accurate control, and the practicality is high, and the heating of menstruum, degassing process are convenient fast, great acceleration test efficiency.

Drawings

Fig. 1 is a schematic structural diagram of the present invention.

Fig. 2 is a perspective view of the medium case 1 of the present invention.

Fig. 3 is a front view of the medium box 1 of the present invention.

Description of the reference numerals

The device comprises a solvent box body 1, a water tank 2, a liquid pumping pipe 21, a liquid pumping pump 22, a liquid inlet pipe 23, a circulating water pump 31, an electric heater 32, a circulating pipe 33, a vacuum suction filter 41, a filter 42, a first suction filter pipe 43, a second suction filter pipe 44, a support 51, a support rod 511, a mounting rack 52, a servo motor 53, a dissolving cup 54, a piston rod 541, a piston 542, a three-way valve 543, a first transmission pipe 55, a first one-way valve 551, a second transmission pipe 56, a second one-way valve 561, a screw rod 57, a rotating seat 571, a lifting seat 58 and a PLC 6.

Detailed Description

For making the technical scheme of the utility model clear more clearly and definitely, it is right to combine the drawing below the utility model discloses further describe, any is right the utility model discloses technical scheme's technical characteristic carries out the scheme that equivalent replacement and conventional reasoning reachs and all falls into the utility model discloses protection scope.

In the description of the present invention, it should be understood that the terms "upper", "lower", "front", "rear", "left", "right", "vertical", "horizontal", "top", "bottom", "inner", "outer", etc. indicate the orientation or positional relationship based on the orientation or positional relationship shown in the drawings, and are only for convenience of description of the present invention and for simplicity of description, and do not indicate or imply that the device or element referred to must have a particular orientation, be constructed and operated in a particular orientation, and therefore should not be construed as limiting the present invention.

As shown in fig. 1-3, the solvent preparation system includes a solvent box 1, and a heating mechanism, a degassing mechanism and a transmission mechanism disposed in the solvent box 1, wherein a water tank 2 is disposed at a lower end of the solvent box 1, a liquid pumping pipe 21 is connected to one side of a top of the water tank 2, a liquid pumping pump 22 is connected to the other end of the liquid pumping pipe 21, a liquid inlet pipe 23 is connected to a water inlet end of the liquid pumping pump 22, and the liquid inlet pipe 23 is communicated with a solvent end, so that the liquid pumping pump 22 delivers the solvent to the water tank 2 through the liquid inlet pipe 23; the heating mechanism comprises a circulating water pump 31, an electric heater 32 and a circulating pipe 33, the electric heater 32 is arranged on the top of the inner wall of the solvent box body 1, the circulating water pump 31 is arranged on one side of the water tank 2, and the electric heater 32, the circulating water pump 31 and the water tank 2 are connected through the circulating pipe 33 to form a closed loop, so that the circulating water pump 31 conveys the solvent to the electric heater 32 through the circulating pipe 33 for heating and conveys the solvent back to the water tank 2 for circulation;

the degassing mechanism comprises a vacuum filter 41, a filter 42, a first suction filter pipe 43 and a second suction filter pipe 44, the filter 42 is arranged on the water tank 2, the filter 42 and the water tank 2 are connected through the first suction filter pipe 43 to form a closed loop, the vacuum filter 41 is arranged on the top of the inner wall of the solvent tank body 1, the air inlet end of the vacuum filter 41 is connected with the second suction filter pipe 44, one end of the second suction filter pipe 44 is communicated with the inside of the filter 42, so that the vacuum filter 41 pumps the solvent in the water tank 2 into the filter 42 for filtering, and removes oxygen in the solvent;

the transmission mechanism is arranged at the top of the solvent box body 1, the transmission mechanism comprises a support 51, an installation frame 52, a servo motor 53, dissolving-out cups 54, a first transmission pipe 55 and a second transmission pipe 56, the support 51 is arranged at the top of the solvent box body 1, a plurality of support rods 511 and a plurality of dissolving-out cups 54 are vertically arranged at the top of the support 51, a plurality of three-way valves 543 are arranged in the support 51, one end of each three-way valve 543 penetrates through the support 51 and is connected with the bottom of the dissolving-out cup 54, two ends of each three-way valve 543 are respectively connected with one first transmission pipe 55 and one second transmission pipe 56, one end of each first transmission pipe 55 enters the bottom of the water box 2, one end of each first transmission pipe 55, which is close to the three-way valve 543, is provided with a first one-way valve 551, so as to prevent the solution discharged from the dissolving-out cups 54 from entering the water box 2, the second transmission pipes 56 penetrate through the top of the solvent box body 1 and respectively transmit the solvent to the dissolving-out cups 54, a second check valve 561 is arranged at one end of the second transmission pipe 56 close to the three-way valve 543 to prevent the piston 542 from sucking air from the second transmission pipe 56 when moving upwards, the top of the dissolution cup 54 is connected with the mounting rack 52, the mounting rack 52 is arranged on the support 51 through the plurality of support rods 511, and the plurality of support rods 511 all penetrate through the bottom of the mounting rack 52 and are fixedly connected with the top of the mounting rack 52; a screw rod 57 is vertically arranged in the middle of the mounting frame 52, a lifting seat 58 is connected to the screw rod 57 in a threaded manner, the lifting seat 58 is penetrated by a plurality of support rods 511, the lifting seat 58 is movably connected with the support rods 511, a plurality of piston rods 541 are vertically arranged around the bottom of the lifting seat 58, a piston 542 is arranged at the bottom of each piston rod 541, and the lower end of each piston rod 541 enters each dissolution cup 54; the upper end and the lower end of the screw 57 are rotatably connected with rotating seats 571, the rotating seats 571 are respectively arranged on the inner walls of the upper end and the lower end of the mounting rack 52, the servo motor 53 is fixedly arranged at the bottom of the mounting rack 52, the output end of the servo motor 53 penetrates through the rotating seats 571 and is fixedly connected with the bottom end of the screw 57, the screw 57 is driven to rotate by the servo motor 53, so that the lifting seat 58 drives the piston rod 541 to move upwards, and the solvent in the water tank 2 is sucked into the dissolution cup 54;

further, a PLC controller 6 is disposed in the mounting bracket 52, and the PLC controller 6 is electrically connected to the liquid pump 22, the electric heater 32, the circulating water pump 31, the vacuum filter 41, and the servo motor 53 through wires.

Further, the number of the dissolution cups 54 is 6, and the 6 dissolution cups 54 are uniformly distributed on the support 51.

Further, the liquid pumping pipe 21, the liquid inlet pipe 23, the circulating pipe 33, the first suction pipe 43, the second suction pipe 44, the first transmission pipe 55, and the second transmission pipe 56 are all silica gel hoses.

Further, the dissolution cups 54 are marked with scales.

Further, the length of the screw 57 is not less than the length of the dissolution cup 54.

The working principle is as follows:

when in use, the PLC 6 controls the liquid pump 22 to deliver the solvent into the water tank 2 through the liquid inlet pipe 23 and the liquid pumping pipe 21, then the circulating water pump 31, the electric heater 32 and the vacuum suction filter 41 are started, the circulating water pump 31 delivers the solvent to the electric heater 32 through the circulating pipe 33 to be heated and delivered back to the water tank 2 for circulation, meanwhile, the vacuum suction filter 41 pumps the solvent in the water tank 2 into the filter 42 for filtration, and removes oxygen in the solvent, after heating and degassing are completed, the servo motor 53 is started, the servo motor 53 drives the screw rod 57 to rotate, and enables the lifting seat 58 to ascend and drive the piston rod 541 in the dissolution cup 54 to ascend to a specified position, meanwhile, under the action of the second one-way valve 561, the solvent in the water tank 2 quantitatively enters each dissolution cup 54 through the first delivery pipe 55, and finally, the servo motor 53 drives the screw rod 57 to reversely rotate, so that the lifting seat 58 drives the piston rod 541 to move downwards, and simultaneously, under the action of the first one-way valve 551, the solvent in each dissolution cup 54 is respectively conveyed to the plurality of dissolution cups 54 through each second conveying pipe 56.

The above description is only for the preferred embodiment of the present invention, but the scope of the present invention is not limited thereto, and any changes or substitutions that can be easily conceived by those skilled in the art within the technical scope of the present invention should be covered by the present invention. Therefore, the protection scope of the present invention shall be subject to the protection scope of the claims.

Claims

1. The solvent preparation system is characterized by comprising a solvent box body (1), and a heating mechanism, a degassing mechanism and a transmission mechanism which are arranged in the solvent box body (1), wherein the lower end of the solvent box body (1) is provided with a water tank (2), one side of the top of the water tank (2) is connected with a liquid pumping pipe (21), the other end of the liquid pumping pipe (21) is connected with a liquid pumping pump (22), and the water inlet end of the liquid pumping pump (22) is connected with a liquid inlet pipe (23); the heating mechanism comprises a circulating water pump (31), an electric heater (32) and a circulating pipe (33), the electric heater (32) is arranged on the top of the inner wall of the solvent box body (1), the circulating water pump (31) is arranged on one side of the water tank (2), and the electric heater (32), the circulating water pump (31) and the water tank (2) are connected through the circulating pipe (33) to form a closed loop;

the degassing mechanism comprises a vacuum suction filter (41), a filter (42), a first suction filter pipe (43) and a second suction filter pipe (44), the filter (42) is arranged on the water tank (2), the filter (42) and the water tank (2) are connected through the first suction filter pipe (43) to form a closed loop, the vacuum suction filter (41) is arranged on the top of the inner wall of the solvent box body (1), the air inlet end of the vacuum suction filter (41) is connected with the second suction filter pipe (44), and one end of the second suction filter pipe (44) is communicated with the inside of the filter (42);

the transmission mechanism is arranged at the top of the solvent box body (1), the transmission mechanism comprises a support (51), an installation frame (52), a servo motor (53), dissolving-out cups (54), a first transmission pipe (55) and a second transmission pipe (56), the support (51) is arranged at the top of the solvent box body (1), a plurality of support rods (511) and a plurality of dissolving-out cups (54) are arranged at the top of the support (51), a plurality of three-way valves (543) are arranged in the support (51), one end of each three-way valve (543) penetrates through the support (51) and is connected with the bottom of each dissolving-out cup (54), two ends of each three-way valve (543) are respectively connected with one first transmission pipe (55) and one second transmission pipe (56), one end of each first transmission pipe (55) enters the bottom of the water tank (2), and one end, close to the three-way valves (543), of each first transmission pipe (55) is provided with a first one-way valve (551), the second transmission pipes (56) penetrate through the top of the solvent box body (1), one end, close to the three-way valve (543), of each second transmission pipe (56) is provided with a second one-way valve (561), the top of the dissolution cup (54) is connected with the mounting rack (52), the mounting rack (52) is arranged on the support (51) through the support rods (511), and the support rods (511) penetrate through the bottom of the mounting rack (52) and are fixedly connected with the top of the mounting rack (52); a screw rod (57) is arranged in the middle of the mounting frame (52), a lifting seat (58) is connected to the screw rod (57) in a threaded manner, the lifting seat (58) is penetrated through by a plurality of supporting rods (511), the lifting seat (58) is movably connected with the supporting rods (511), a plurality of piston rods (541) are arranged around the bottom of the lifting seat (58), a piston (542) is arranged at the bottom of each piston rod (541), and the lower end of each piston rod (541) enters each dissolving-out cup (54) respectively; the upper end and the lower end of the screw rod (57) are rotatably connected with rotating seats (571), the rotating seats (571) are respectively arranged on the inner walls of the upper end and the lower end of the mounting rack (52), the servo motor (53) is arranged at the bottom of the mounting rack (52), and the output end of the servo motor (53) penetrates through the rotating seats (571) and is fixedly connected with the bottom end of the screw rod (57).

2. The solvent preparation system as claimed in claim 1, wherein a PLC controller (6) is further disposed in the mounting rack (52), and the PLC controller (6) is electrically connected to the liquid pump (22), the electric heater (32), the water circulating pump (31), the vacuum filter (41) and the servo motor (53) through wires.

3. The vehicle preparation system according to claim 1, wherein the number of dissolution cups (54) is 6 and the 6 dissolution cups (54) are evenly distributed on the support (51).

4. The solvent preparation system as set forth in claim 1, wherein the liquid suction pipe (21), the liquid inlet pipe (23), the circulation pipe (33), the first suction filtration pipe (43), the second suction filtration pipe (44), the first transfer pipe (55), and the second transfer pipe (56) are all silicone hoses.

5. The vehicle preparation system of claim 1, wherein said dissolution cups (54) are graduated.

6. The vehicle preparation system of claim 1, wherein the lead screw (57) has a length not less than the length of the dissolution cup.