CN217156188U

CN217156188U - Circulation pumping system for solvent by flow cell method

Info

Publication number: CN217156188U
Application number: CN202123354520.7U
Authority: CN
Inventors: 李定中; 季超; 朱天德; 宋水军; 雷浩
Original assignee: Lugen Shanghai Life Technology Co ltd
Current assignee: Lugen Shanghai Life Technology Co ltd
Priority date: 2021-12-28
Filing date: 2021-12-28
Publication date: 2022-08-09
Anticipated expiration: 2031-12-28

Abstract

The utility model relates to a circulation cell method menstruum circulation pumping system, including frame and the four groups of pumping mechanisms of setting in the frame, transverse arrangement sets up four groups of pumping mechanisms in the frame, each group of pumping mechanism all includes the installation shell, the mounting panel, driving motor, the lift seat, the lead screw, pump the pipe, set up the mounting panel in the installation shell, set up two driving motor on the mounting panel, both sides of mounting panel bottom are vertically equipped with two sets of guide bars respectively, slide respectively on two sets of guide bars and set up a lift seat, each lift seat middle part all runs through and sets up a lead screw, two lead screws are driven through two driving motor respectively, make two lift seats move to opposite direction, the rotational speed is the same between two driving motor in each group of pumping mechanism, and the rotational speed of driving motor is all the same in different pumping mechanisms; the method realizes that the menstruum in the flow cell keeps different flow rates, thereby being capable of truly simulating the release condition of the medicament in the human body environment and meeting the technical requirements of the medicament dissolution test by the flow cell method.

Description

Solvent circulating pumping system adopting flow cell method

Technical Field

The utility model belongs to the technical field of the medicine test equipment, concretely relates to flow cell method menstruum circulation pumping system.

Background

The traditional drug dissolution rate determination method (paddle method, basket method and the like) has new problems in the process of determining the quality of the preparation, such as the determination of trace drug preparations, the formulation of novel medicaments such as patches, microspheres and the like, and the aspect of how to solve the in vivo and in vitro correlation of the quick-release preparation. As a novel dissolution concentration detection method, the flow cell method mainly depends on flowing solvent to continuously wash the preparation, and can well simulate the in vivo circulation of the medicine in a human body. The menstruum mainly flows through a plurality of flowerpots through the circulation system, and a menstruum circulating pumping system in the prior art adopts two circulation pumps to control 8 pipelines, so that the flow rate of the menstruum in the 8 flowerpots keeps constant, the dissolution condition of the medicament in the flowerpots at different flow rates of the menstruum cannot be tested, and the requirement of a systematic dissolution test by a flowerpot method cannot be met.

SUMMERY OF THE UTILITY MODEL

The utility model provides a to above-mentioned problem discloses a circulation pond method menstruum circulation pumping system, has solved among the prior art storage rack simple structure, the not convenient for classification management's problem.

The specific technical scheme is as follows:

a solvent circulating pumping system adopting a flow cell method comprises a frame and four groups of pumping mechanisms arranged in the frame, wherein the four groups of pumping mechanisms are transversely arranged in the frame, each group of pumping mechanisms comprises an installation shell, an installation plate, driving motors, lifting seats, screw rods and pumping pipes, the installation plate is horizontally arranged in the installation shell, two driving motors are respectively arranged on two sides of the installation plate, two groups of guide rods are respectively and longitudinally arranged on two sides of the bottom of the installation plate, one lifting seat is respectively and slidably arranged on the two groups of guide rods, the middle part of each lifting seat is provided with one screw rod in a penetrating way, the screw rods are in threaded connection with the lifting seats, the top ends of the two screw rods are respectively driven by the two driving motors, the two driving motors drive the two lifting seats to move in opposite directions, and the rotating speeds of the two driving motors in each group of pumping mechanisms are the same, the rotating speeds of the driving motors in different pumping mechanisms are different; the front end of the mounting plate is transversely provided with a plurality of pipe holes, the front end of the top of the mounting shell is horizontally provided with a first three-way valve island, two groups of pumping pipes are longitudinally arranged between a port at the bottom of the first three-way valve island and the pipe holes on the mounting plate, the upper ends of the pumping pipes are communicated with the first three-way valve island, the number of the pumping pipes in each group is two, a piston rod is movably arranged in each pumping pipe, the top of each piston rod is provided with a piston head, and the bottoms of the piston rods in the two groups of pumping pipes are respectively connected with the tops of the two lifting seats; the front end of the top of the rack is transversely provided with four three-way valve islands II, the position of each three-way valve island II is respectively positioned above one three-way valve island I, and each three-way valve island II is respectively connected with one three-way valve island I and the drug dissolution device through a pipeline, so that the circulation of menstruum is realized.

Further, the rack and the mounting shell are both rectangular frame structures.

Furthermore, the rear end of the mounting plate, which is positioned in the plurality of pipe holes, is longitudinally provided with a baffle plate, and the upper end of the baffle plate is connected with the top end of the mounting shell.

Furthermore, the front end of the mounting plate is longitudinally provided with a cover plate, and the bottom of the cover plate is connected with the bottom end of the mounting shell.

Furthermore, a first driving wheel is arranged at the output end of the driving motor, a second driving wheel is arranged at the top end of the screw rod, and the first driving wheel and the second driving wheel are in transmission connection through a transmission belt.

Furthermore, the pumping pipe is made of a transparent glass pipe.

The beneficial effects of the utility model are embodied in:

(1) the utility model discloses a plurality of flow cell pipelines that four pumping mechanisms can dissolve out in the device to the medicine are controlled, realize that the menstruum in the flow cell keeps different velocity of flow to can test out the medicine and release the condition in the menstruum of different velocity of flow, satisfy the experimental technical requirement of flow cell method medicine degree of dissolution, the practicality is high.

(2) The utility model discloses a two sets of pumping installations cooperation three-way valve island one and three-way valve island two realize the incessant transport of menstruum, and the simulation medicine that can be true releases the condition under human environment satisfies the experimental technical requirement of circulation cell method medicine degree of dissolution.

Drawings

Fig. 1 is a schematic structural diagram of the present invention.

Fig. 2 is a schematic front structural diagram of the middle pumping mechanism of the present invention.

Fig. 3 is a schematic diagram of a back structure of the pumping mechanism of the present invention.

Fig. 4 is a working schematic diagram of the middle circulation pumping system of the present invention.

The device comprises a frame 1, a pumping mechanism 2, an installation shell 3, an installation plate 4, a pipe hole 41, a driving motor 5, a first transmission wheel 51, a lifting seat 6, a screw rod 7, a second transmission wheel 71, a guide rod 8, a pumping pipe 9, a piston rod 10, a piston head 11, a three-way valve island I12, a three-way valve island II 13, a cover plate 14, a baffle plate 15 and a drug dissolution device 16.

Detailed Description

For making the technical scheme of the utility model clear more clearly and definitely, it is right to combine the drawing below the utility model discloses further describe, any is right the utility model discloses technical scheme's technical characteristic carries out the scheme that equivalent replacement and conventional reasoning reachs and all falls into the utility model discloses protection scope. The utility model discloses in the fixed connection who mentions, fixed setting is the general connected mode among the mechanical field, and welding, bolt and nut are connected and the screw connection is all can.

In the description of the present invention, it should be understood that the terms "upper", "lower", "front", "rear", "left", "right", "vertical", "horizontal", "top", "bottom", "inner", "outer", etc. indicate the orientation or positional relationship based on the orientation or positional relationship shown in the drawings, and are only for convenience of description of the present invention and for simplicity of description, and do not indicate or imply that the device or element referred to must have a particular orientation, be constructed and operated in a particular orientation, and therefore should not be construed as limiting the present invention.

As shown in fig. 1-4, a solvent circulating pumping system by a flow cell method comprises a frame 1 and four sets of pumping mechanisms 2 arranged in the frame 1, wherein the four sets of pumping mechanisms 2 are transversely arranged in the frame 1, each set of pumping mechanism 2 comprises an installation shell 3, an installation plate 4, driving motors 5, lifting seats 6, screw rods 7 and pumping pipes 9, the installation plate 4 is horizontally arranged in the installation shell 3, two driving motors 5 are respectively arranged on two sides of the installation plate 4, two sets of guide rods 8 are respectively and longitudinally arranged on two sides of the bottom of the installation plate 4, one lifting seat 6 is respectively arranged on the two sets of guide rods 8 in a sliding manner, one screw rod 7 is arranged in the middle of each lifting seat 6 in a penetrating manner, the screw rods 7 are in threaded connection with the lifting seats 6, the top ends of the two screw rods 7 are respectively driven by the two driving motors 5, and the two driving motors 5 drive the two lifting seats 6 to move in opposite directions, the rotating speeds of the two driving motors 5 in each group of pumping mechanisms 2 are the same, and the rotating speeds of the driving motors 5 in different pumping mechanisms 2 are different; the front end of the mounting plate 4 is transversely provided with a plurality of pipe holes 41, the front end of the top of the mounting shell 3 is horizontally provided with a first three-way valve island 12, two groups of pumping pipes 9 are longitudinally arranged between the port at the bottom of the first three-way valve island 12 and the pipe holes 41 on the mounting plate 4, the upper ends of the pumping pipes 9 are communicated with the first three-way valve island 12, an inlet end and an outlet end are respectively communicated with each pumping pipe 9 on the first three-way valve island 12, the number of each group of pumping pipes 9 is two, a piston rod 10 is movably arranged in each pumping pipe 9, the top of the piston rod 10 is provided with a piston head 11 for sucking and discharging liquid, and the bottoms of the piston rods 10 in the two groups of pumping pipes 9 are respectively connected with the tops of the two lifting seats 6; the front end of the top of the frame 1 is transversely provided with four three-way valve islands II 13, the position of each three-way valve island II 13 is respectively positioned above one three-way valve island I12, and each three-way valve island II 13 is respectively connected with one three-way valve island I12 and the drug dissolution device 16 through a pipeline, so that the circulation of a solvent is realized.

Further, the rack 1 and the installation shell 3 are both rectangular frame structures.

Furthermore, a baffle plate 15 is longitudinally arranged at the rear end of the mounting plate 4 at the plurality of pipe holes 41, and the upper end of the baffle plate 15 is connected with the top end of the mounting shell 3.

Furthermore, a cover plate 14 is longitudinally arranged at the front end of the mounting plate 4, and the bottom of the cover plate 14 is connected with the bottom end of the mounting shell 3.

Furthermore, a first driving wheel 51 is arranged at the output end of the driving motor 5, a second driving wheel 71 is arranged at the top end of the screw rod 7, and the first driving wheel 51 is in transmission connection with the second driving wheel 71 through a transmission belt.

Further, the pumping pipe 9 is made of a transparent glass pipe.

The working principle is as follows: when the device works, in the pumping mechanism 2, the two driving motors 5 drive the two lifting seats 6 to lift through the screw rods 7, so that one lifting seat 6 is lifted, the other lifting seat 6 is lifted, and the two groups of pumping pipes 9 are respectively used for sucking liquid and discharging liquid, thereby keeping the continuous flow of a solvent.

The above description is only for the preferred embodiment of the present invention, but the scope of the present invention is not limited thereto, and any changes or substitutions that can be easily conceived by those skilled in the art within the technical scope of the present invention should be covered by the present invention. Therefore, the protection scope of the present invention shall be subject to the protection scope of the claims.

Claims

1. A solvent circulating pumping system adopting a flow cell method is characterized by comprising a rack (1) and four groups of pumping mechanisms (2) arranged in the rack (1), wherein the four groups of pumping mechanisms (2) are transversely arranged in the rack (1), each group of pumping mechanisms (2) comprises an installation shell (3), an installation plate (4), a driving motor (5), a lifting seat (6), a screw rod (7) and a pumping pipe (9), the installation plate (4) is horizontally arranged in the installation shell (3), two driving motors (5) are respectively arranged on two sides of the installation plate (4), two groups of guide rods (8) are respectively and longitudinally arranged on two sides of the bottom of the installation plate (4), one lifting seat (6) is respectively arranged on the two groups of guide rods (8) in a sliding manner, one screw rod (7) is arranged in the middle of each lifting seat (6) in a penetrating manner, and the screw rod (7) is in threaded connection with the lifting seats (6), the top ends of the two screw rods (7) are respectively driven by the two driving motors (5), the two driving motors (5) drive the two lifting seats (6) to move in opposite directions, the rotating speeds of the two driving motors (5) in each group of pumping mechanisms (2) are the same, and the rotating speeds of the driving motors (5) in different pumping mechanisms (2) are different; the front end of the mounting plate (4) is transversely provided with a plurality of pipe holes (41), the front end of the top of the mounting shell (3) is horizontally provided with a first three-way valve island (12), two groups of pumping pipes (9) are longitudinally arranged between a port at the bottom of the first three-way valve island (12) and the pipe holes (41) on the mounting plate (4), the upper ends of the pumping pipes (9) are communicated with the first three-way valve island (12), each group of pumping pipes (9) is provided with two pumping pipes, a piston rod (10) is movably arranged in each pumping pipe (9), the top of each piston rod (10) is provided with a piston head (11), and the bottoms of the piston rods (10) in the two groups of pumping pipes (9) are respectively connected with the tops of the two lifting seats (6); the front end of the top of the frame (1) is transversely provided with four three-way valve islands II (13), the position of each three-way valve island II (13) is respectively positioned above one three-way valve island I (12), and each three-way valve island II (13) is respectively connected with one three-way valve island I (12) and the drug dissolution device (16) through a pipeline, so that the circulation of a solvent is realized.

2. A flow cell solvent circulating pumping system as claimed in claim 1, wherein the frame (1) and the mounting housing (3) are both rectangular frame structures.

3. The system for circulation pumping of solvent through a flow cell method as claimed in claim 2, wherein a baffle (15) is longitudinally arranged at the rear end of the plurality of pipe holes (41) on the mounting plate (4), and the upper end of the baffle (15) is connected with the top end of the mounting shell (3).

4. A flow-cell solvent circulating pumping system as claimed in claim 2, wherein the front end of the mounting plate (4) is provided with a cover plate (14) longitudinally, and the bottom of the cover plate (14) is connected with the bottom end of the mounting shell (3).

5. The system for solvent circulation pumping by the flow cell method as claimed in claim 1, wherein the output end of the driving motor (5) is provided with a first driving wheel (51), the top end of the screw rod (7) is provided with a second driving wheel (71), and the first driving wheel (51) and the second driving wheel (71) are in transmission connection through a transmission belt.

6. The system for circulation pumping of solvent through a flow cell method as claimed in claim 1, wherein the material of the pumping tube (9) is a transparent glass tube.