CN213667526U - Wearable ultrasonic iontophoresis transdermal drug delivery system - Google Patents
Wearable ultrasonic iontophoresis transdermal drug delivery system Download PDFInfo
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- CN213667526U CN213667526U CN202021778245.4U CN202021778245U CN213667526U CN 213667526 U CN213667526 U CN 213667526U CN 202021778245 U CN202021778245 U CN 202021778245U CN 213667526 U CN213667526 U CN 213667526U
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- Prior art keywords
- electrode
- drug delivery
- delivery system
- ultrasound
- iontophoresis
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- 238000013271 transdermal drug delivery Methods 0.000 title claims abstract description 37
- 229910052751 metal Inorganic materials 0.000 claims abstract description 22
- 239000002184 metal Substances 0.000 claims abstract description 22
- 230000005684 electric field Effects 0.000 claims abstract description 15
- 238000002604 ultrasonography Methods 0.000 claims description 40
- 239000003814 drug Substances 0.000 abstract description 21
- 230000000694 effects Effects 0.000 abstract description 15
- 229940079593 drug Drugs 0.000 abstract description 14
- 239000013543 active substance Substances 0.000 abstract description 11
- 239000000126 substance Substances 0.000 abstract description 6
- 238000001647 drug administration Methods 0.000 abstract description 4
- 229940126678 chinese medicines Drugs 0.000 abstract description 2
- 235000015097 nutrients Nutrition 0.000 abstract description 2
- 150000002500 ions Chemical class 0.000 description 16
- 210000001519 tissue Anatomy 0.000 description 9
- 230000017531 blood circulation Effects 0.000 description 4
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 3
- 238000010586 diagram Methods 0.000 description 3
- 238000009434 installation Methods 0.000 description 3
- 239000000741 silica gel Substances 0.000 description 3
- 229910002027 silica gel Inorganic materials 0.000 description 3
- HBBGRARXTFLTSG-UHFFFAOYSA-N Lithium ion Chemical compound [Li+] HBBGRARXTFLTSG-UHFFFAOYSA-N 0.000 description 2
- 229910001416 lithium ion Inorganic materials 0.000 description 2
- 210000000056 organ Anatomy 0.000 description 2
- 206010033675 panniculitis Diseases 0.000 description 2
- 210000004304 subcutaneous tissue Anatomy 0.000 description 2
- 230000001839 systemic circulation Effects 0.000 description 2
- 230000037317 transdermal delivery Effects 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 1
- 238000005460 biophysical method Methods 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 238000012377 drug delivery Methods 0.000 description 1
- 230000010354 integration Effects 0.000 description 1
- 238000010030 laminating Methods 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 238000007910 systemic administration Methods 0.000 description 1
- 230000009885 systemic effect Effects 0.000 description 1
- 210000000707 wrist Anatomy 0.000 description 1
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Abstract
The utility model discloses a leading-in transdermal drug delivery system of wearing formula supersound ion includes at least: a wearing ring; the first electrode and the second electrode are fixed on the wearing ring and oppositely arranged, and the first electrode and the second electrode form an ion introduction module; an ultrasonic generating module fixed on the wearing ring; and a transdermal patch for carrying active substances (chemical drugs, Chinese medicines, nutrients, etc.) and attaching to the skin surface; the ultrasonic generation module and the first electrode directly act on the transdermal patch; the utility model can continuously transdermal drug delivery for 24 hours; the position of the transdermal patch can be accurately positioned by the design of the metal buckle, so that the drug administration effect is ensured; the ultrasonic transducer enhances the drug administration effect through vibration; the drug introduction effect on the electrode electric field is stronger.
Description
Technical Field
The utility model relates to an ion leading-in transdermal drug delivery system, especially a wearing formula supersound ion leading-in transdermal drug delivery system.
Background
The ion introduction technology is a biophysical method for introducing medicine ions into local tissues or blood circulation by positioning through electrodes by using direct current, and the existing ion introduction administration instrument is large and inconvenient to use at any time.
Therefore, there is a need for a wearable ultrasound iontophoresis transdermal drug delivery system.
Disclosure of Invention
The utility model provides a wearing formula supersound iontophoresis transdermal drug delivery system has solved the problem that iontophoresis transdermal drug delivery system is difficult to hand-carried use, has ensured the long-term stable supply of medicine.
The utility model adopts the following technical proposal that the wearable ultrasound iontophoresis transdermal drug delivery system is characterized by at least comprising:
a wearing ring; the donning loop includes, but is not limited to, a collar, belt, wrist band, arm ring, etc.; the wearing ring may be an integral structure or an annular structure formed by a plurality of link units, and the link units may be connected by a pin, but not limited thereto.
The first electrode and the second electrode are fixed on the wearing ring and oppositely arranged to form an electric field, and the first electrode and the second electrode form an ion introduction module; the first electrode and the second electrode may be metal electrode sheets, but are not limited thereto.
An ultrasonic generating module fixed on the wearing ring;
and a transdermal patch for carrying active substances (chemical drugs, Chinese medicines, nutrients, etc.) and attaching to the skin surface;
the ultrasound generating module and the first electrode act directly on the transdermal patch. A stable low-current direct current electric field is generated between the first electrode and the second electrode, and the stable low-current direct current electric field acts on the drug ions on the transdermal patch in a directional mode. Drug ions can enter subcutaneous tissues and capillaries through the skin, and can be kept at higher concentration in local tissues for a longer time (local administration); or enter the systemic circulation through capillary vessels to reach target organs (systemic drug delivery), and the ultrasonic transducer emits ultrasonic waves to the transdermal patch to enhance the iontophoresis effect by high-frequency vibration. In the application, the wearable ultrasound iontophoresis transdermal drug delivery system further comprises a power supply module, wherein the power supply module supplies power to the iontophoresis module and the ultrasound generation module, so that an electric field is formed between two electrodes of the iontophoresis module; the power supply module includes, but is not limited to, an internal or external type. The external device comprises an external power supply, a mobile charger and the like. The built-in power supply module is positioned in the wearing ring, can be composed of a flexible battery (suitable for the wearing ring with an integrated structure) or a plurality of battery blocks (suitable for the annular structure composed of a plurality of chain link units), the battery blocks can be connected in series or in parallel, and the electrical series or parallel connection can be realized through a metal core arranged in the pin shaft (as the common knowledge in the field, the metal core is insulated from the pin shaft body).
In this application, the ultrasound generation module may be an ultrasonic transducer.
The ultrasound transducer and the first electrode can be fixed to a housing, since the ultrasound generating module and the first electrode together act directly on the transdermal patch.
In the present application, the first electrode is disposed in the middle of the housing, or the ultrasonic transducer is disposed in the middle of the housing.
Transdermal patches, as is conventional in the art, typically carry a sufficient amount of a chemically or pharmaceutically active substance and may also have transdermal microneedles. In this application, wearing formula supersound iontophoresis transdermal drug delivery system, still include the controller in the casing, the controller with ultrasonic transducer, first electrode and second electrode link to each other. According to the different drug concentration of the transdermal patch and the treatment requirement, the controller controls the polarity of the first electrode and the second electrode and the current voltage intensity between the first electrode and the second electrode, and the controller controls the vibration frequency and amplitude of the ultrasonic transducer, and the like, and the specific control mode is common knowledge in the field.
In some preferred embodiments, the first electrode is provided with a first metal buckle, and a second metal buckle correspondingly buckled with the first metal buckle is arranged in the middle of the transdermal patch, so that the position of the transdermal patch is fixed, and the effect of ion introduction is ensured.
Compared with the prior art, the utility model discloses wearing formula supersound iontophoresis transdermal drug delivery system's beneficial effect lies in:
(1) through the integration of all modules, the transdermal drug delivery can be continuously carried on for 24 hours;
(2) the position of the transdermal patch can be accurately positioned by the design of the metal buckle, so that the drug administration effect is ensured;
(3) the ultrasonic transducer enhances the drug administration effect through vibration;
(4) the electric field of the counter electrode leads the medicine to be guided in directionally and has stronger effect.
Drawings
FIG. 1 is a schematic front view of the internal structure of the wearable ultrasound iontophoresis transdermal drug delivery system of the present invention;
FIG. 2 is a schematic diagram of an electrical connection of a wearing ring of the internal structure of the wearable ultrasound iontophoresis transdermal drug delivery system of the present invention;
FIG. 3 is a schematic front view of a second embodiment of the wearable ultrasound iontophoresis transdermal drug delivery system of the present invention;
FIG. 4 is a schematic diagram of the electrical connections of the wearing ring of the second and fourth embodiments of the wearable ultrasound iontophoresis transdermal drug delivery system of the present invention;
FIG. 5 is a schematic front view of a third embodiment of a wearable ultrasound iontophoresis transdermal delivery system of the present invention;
FIG. 6 is a schematic diagram of the electrical connection of the wearing ring of the third embodiment of the wearable ultrasound iontophoresis transdermal drug delivery system of the present invention;
FIG. 7 is a schematic illustration of a fourth embodiment of the wearable ultrasound iontophoresis transdermal delivery system of the present invention in elevation view;
wherein: 1: wearing ring, 1-1: wearing ring shell, 1-2: battery mounting groove, 1-3: an electric wire; 1-4: battery block, 1-5: pin shaft, 2: first electrode, 3: second electrode, 4: ultrasonic transducer, 5: transdermal patch, 6: a housing, 7: controller, 8: a second housing.
Detailed Description
The following detailed description of the specific implementation steps is provided in conjunction with the accompanying drawings:
example one
As shown in figures 1-2, it is an embodiment of the wearable ultrasound iontophoresis transdermal drug delivery system of the present invention. A wearable ultrasound iontophoresis transdermal drug delivery system, comprising:
(1) the wearable ring 1 comprises a wearable ring shell 1-1, wherein the wearable ring shell 1-1 is made of silica gel and is in a hollow annular shape, a plurality of battery installation grooves 1-2 are formed in the wearable ring shell and used for installing a plurality of battery blocks 1-4 forming a power supply module, in the embodiment, the battery blocks 1-4 adopt lithium ion batteries, and the battery blocks 1-4 are connected in a flexible electric wire 1-3 mode.
(2) Fix casing 6 and second electrode 3 on wearing ring 1, 6 both ends of casing are fixed wear ring 1 is last, and second electrode 3 is fixed at wearing ring 1 surface to the laminating skin. The inner side surface of the shell 6, which is attached to the skin, is fixedly provided with the ultrasonic transducer 4 and the first electrode 2, the first electrode 2 is positioned in the middle of the shell, the first electrode 2 and the second electrode 3 are oppositely arranged, and the first electrode 2 and the second electrode 3 are metal electrode plates;
(3) a transdermal patch 5 attached to the skin surface; the ultrasonic transducer 4 and the first electrode 2 are directly attached to the transdermal patch 5, and the transdermal patch 5 contains chemical active substances or traditional Chinese medicine active substances.
As shown in fig. 2, a power supply module formed by connecting a plurality of battery blocks 1-4 in series supplies power to the ultrasonic transducer 4, so that the ultrasonic transducer 4 generates ultrasonic waves, and the ultrasonic transducer 4 sends the ultrasonic waves to the transdermal patch 5 to enhance the iontophoresis effect by high-frequency vibration; meanwhile, two electrodes are connected to form an electric field, and the drug ions on the transdermal patch 5 directly penetrate through the skin to enter subcutaneous tissues and capillary vessels by utilizing the electric field, so that higher concentration and longer time (local administration) are kept in local tissues or enter the systemic circulation through the capillary vessels to reach target organs (systemic administration) to achieve the purpose of treatment.
In this embodiment, be provided with first metal buckle in the middle of first electrode 2, be provided with in the middle of transdermal patch 5 with the second metal buckle of the corresponding lock of first metal buckle for the position of location transdermal patch guarantees the leading-in effect of ion.
In this embodiment, the controller 7 controls the polarities of the first electrode 2 and the second electrode 3 and the current-voltage intensity therebetween according to the concentration of the drug in the transdermal patch 5, and the controller 7 controls the vibration frequency and amplitude of the ultrasonic transducer, and the specific control manner is common knowledge in the art.
Example two
As shown in FIGS. 3-4, it is another embodiment of the wearable ultrasound iontophoresis transdermal drug delivery system of the present invention. A wearable ultrasound iontophoresis transdermal drug delivery system, comprising:
(1) the wearable ring 1 comprises a wearable ring shell 1-1, wherein the wearable ring shell 1-1 is made of silica gel and is in a hollow annular shape, a battery installation groove 1-2 is formed in the wearable ring shell and used for installing a battery block 1-4 forming a power supply module, and in the embodiment, the battery block 1-4 adopts a flexible battery.
(2) The ultrasonic transducer 4, the first electrode 2 and the second electrode 3 are directly fixed on the wearing ring 1, the ultrasonic transducer 4, the first electrode 2 and the second electrode 3 are all fixed on the inner side surface of the wearing ring 1, which is attached to the skin, the first electrode 2 and the second electrode 3 are oppositely arranged, and the first electrode 2 and the second electrode 3 are metal electrode plates;
(3) a transdermal patch 5 attached to the skin surface; the ultrasonic transducer 4 and the first electrode 2 are directly attached to the transdermal patch 5, and the transdermal patch 5 contains chemical active substances or traditional Chinese medicine active substances.
As shown in fig. 4, the battery blocks 1-4 supply power to the ultrasonic transducer 4 to make it generate ultrasonic waves, and the ultrasonic transducer 4 sends the ultrasonic waves to the transdermal patch 5 to enhance the iontophoresis effect by high-frequency vibration; meanwhile, two electrodes are connected to form an electric field, and the drug ions on the transdermal patch 5 directly penetrate into the tissue by the electric field without blood circulation, so that higher concentration and longer time can be kept in the tissue to achieve the purpose of treatment.
In this embodiment, the controller 7 controls the polarities of the first electrode 2 and the second electrode 3 and the current-voltage intensity therebetween according to the concentration of the drug in the transdermal patch 5, and the controller 7 controls the vibration frequency and amplitude of the ultrasonic transducer, and the specific control manner is common knowledge in the art.
EXAMPLE III
As shown in FIGS. 5-6, it is another embodiment of the wearable ultrasound iontophoresis transdermal drug delivery system of the present invention. A wearable ultrasound iontophoresis transdermal drug delivery system, comprising:
(1) a plurality of battery compartments, a first housing 6, a second housing 8; the battery bins, the first shell 6 and the second shell 8 are connected through a pin shaft to form a wearing ring.
Wherein, the inner side surface of the first shell 6, which is attached to the skin, is fixed with an ultrasonic transducer 4 and a first electrode 2; the inner side surface of the second shell, which is attached to the skin, is fixed with a second electrode 3; the first electrode 2 and the second electrode 3 are oppositely arranged, and the first electrode 2 and the second electrode 3 are metal electrode plates.
The battery compartment is internally provided with battery mounting grooves 1-2 for mounting battery blocks 1-4 forming a power supply module, in the embodiment, the battery blocks 1-4 adopt lithium ion batteries, and the battery blocks 1-4 are connected in series or in parallel through pin shafts (as shown in fig. 6, the battery compartment is structurally connected through the pin shafts, and the battery blocks 1-4 are electrically connected); as is common knowledge in the art, the pin shaft has an insulating coating to prevent electrical leakage.
(2) A transdermal patch 5 attached to the skin surface; the ultrasonic transducer 4 and the first electrode 2 are directly attached to the transdermal patch 5, and the transdermal patch 5 contains chemical active substances or traditional Chinese medicine active substances.
As shown in fig. 6, a power supply module formed by a plurality of battery blocks 1-4 supplies power to the ultrasonic transducer 4 to enable the ultrasonic transducer to generate ultrasonic waves, and the ultrasonic transducer 4 sends the ultrasonic waves to the transdermal patch 5 to enhance the iontophoresis effect by high-frequency vibration; meanwhile, two electrodes are connected to form an electric field, and the drug ions on the transdermal patch 5 directly penetrate into the tissue by the electric field without blood circulation, so that higher concentration and longer time can be kept in the tissue to achieve the purpose of treatment.
In this embodiment, the first electrode 2 is provided with a first metal buckle, the middle of the transdermal patch 5 is provided with a second metal buckle correspondingly buckled with the first metal buckle, and the second metal buckle is used for positioning the position of the transdermal patch and ensuring the ion introduction effect.
In this embodiment, the controller 7 controls the polarities of the first electrode 2 and the second electrode 3 and the current-voltage intensity therebetween according to the concentration of the drug in the transdermal patch 5, and the controller 7 controls the vibration frequency and amplitude of the ultrasonic transducer, and the specific control manner is common knowledge in the art.
Example four
Fig. 4 and 7 show another embodiment of the wearable ultrasound iontophoresis transdermal drug delivery system of the present invention. A wearable ultrasound iontophoresis transdermal drug delivery system, comprising:
(1) the wearable ring 1 comprises a wearable ring shell 1-1, wherein the wearable ring shell 1-1 is made of silica gel and is in a hollow annular shape, a battery installation groove 1-2 is formed in the wearable ring shell and used for installing a battery block 1-4 forming a power supply module, and in the embodiment, the battery block 1-4 adopts a flexible battery.
(2) The ultrasonic transducer 4, the first electrode 2 and the second electrode 3 are directly fixed on the wearing ring 1, the ultrasonic transducer 4, the first electrode 2 and the second electrode 3 are all fixed on the inner side surface of the wearing ring 1, which is attached to the skin, the first electrode 2 and the second electrode 3 are oppositely arranged, and the first electrode 2 and the second electrode 3 are metal electrode plates; the first electrode 2 also comprises a "C" -shaped support.
(3) A transdermal patch 5 attached to the skin surface; the ultrasonic transducer 4 and the first electrode 2 are directly attached to the transdermal patch 5, the transdermal patch 5 contains chemical active substances or traditional Chinese medicine active substances, and the transdermal patch 5 is arranged in a C-shaped bracket of the first electrode 2 and used for positioning the position of the transdermal patch and conducting current to the transdermal patch 5; in order to ensure that the transdermal patch 5 can be well attached to the skin, the wall thickness of the C-shaped bracket is ultrathin, and the ion introduction effect is ensured; and the contact surface of the C-shaped bracket and the skin can be provided with an insulating layer to prevent the human body from contacting the first electrode 2 too much and being subjected to additional electric stimulation.
As shown in fig. 4, the battery blocks 1-4 supply power to the ultrasonic transducer 4 to make it generate ultrasonic waves, and the ultrasonic transducer 4 sends the ultrasonic waves to the transdermal patch 5 to enhance the iontophoresis effect by high-frequency vibration; meanwhile, two electrodes are connected to form an electric field, and the drug ions on the transdermal patch 5 directly penetrate into the tissue by the electric field without blood circulation, so that higher concentration and longer time can be kept in the tissue to achieve the purpose of treatment.
In this embodiment, the controller 7 controls the polarities of the first electrode 2 and the second electrode 3 and the current-voltage intensity therebetween according to the concentration of the drug in the transdermal patch 5, and the controller 7 controls the vibration frequency and amplitude of the ultrasonic transducer, and the specific control manner is common knowledge in the art.
Claims (10)
1. A wearable ultrasound iontophoretic transdermal drug delivery system, comprising at least:
a wearing ring;
the first electrode and the second electrode are fixed on the wearing ring and oppositely arranged to form an electric field, and the first electrode and the second electrode form an ion introduction module;
an ultrasonic generating module fixed on the wearing ring;
and a transdermal patch, for attaching to the skin surface;
the ultrasound generating module and the first electrode act directly on the transdermal patch.
2. The wearable ultrasound iontophoresis transdermal drug delivery system of claim 1, further comprising a power module to power the iontophoresis module and the ultrasound generation module.
3. The wearable ultrasound iontophoresis transdermal drug delivery system of claim 2, wherein the power module is located within the wearable ring.
4. The wearable ultrasound iontophoresis transdermal drug delivery system of claim 3, wherein the power module is comprised of a plurality of battery blocks.
5. The wearable ultrasound iontophoresis transdermal drug delivery system of claim 3, wherein the power module consists of one flexible battery.
6. The wearable ultrasound iontophoresis transdermal drug delivery system of claim 1, wherein the ultrasound generating module is an ultrasound transducer.
7. The wearable ultrasound iontophoresis transdermal drug delivery system of claim 6, wherein the ultrasound transducer and the first electrode are fixed to a housing.
8. The wearable ultrasound iontophoresis transdermal drug delivery system of claim 7, wherein the first electrode is disposed in the middle of the housing, or the ultrasound transducer is disposed in the middle of the housing.
9. The wearable ultrasound iontophoresis transdermal drug delivery system of claim 7, further comprising a controller within the housing, the controller being connected to the ultrasound transducer, the first electrode, and the second electrode, respectively.
10. The wearable ultrasound iontophoresis transdermal drug delivery system according to claim 1, wherein the first electrode is provided with a first metal buckle, and the transdermal patch is provided with a second metal buckle correspondingly buckled with the first metal buckle in the middle.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202021778245.4U CN213667526U (en) | 2020-08-24 | 2020-08-24 | Wearable ultrasonic iontophoresis transdermal drug delivery system |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202021778245.4U CN213667526U (en) | 2020-08-24 | 2020-08-24 | Wearable ultrasonic iontophoresis transdermal drug delivery system |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN213667526U true CN213667526U (en) | 2021-07-13 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202021778245.4U Expired - Fee Related CN213667526U (en) | 2020-08-24 | 2020-08-24 | Wearable ultrasonic iontophoresis transdermal drug delivery system |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN213667526U (en) |
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2020
- 2020-08-24 CN CN202021778245.4U patent/CN213667526U/en not_active Expired - Fee Related
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Granted publication date: 20210713 |