CN213607139U - Experimental animal fixing device and animal experiment system - Google Patents
Experimental animal fixing device and animal experiment system Download PDFInfo
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- CN213607139U CN213607139U CN202021748824.4U CN202021748824U CN213607139U CN 213607139 U CN213607139 U CN 213607139U CN 202021748824 U CN202021748824 U CN 202021748824U CN 213607139 U CN213607139 U CN 213607139U
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- 210000005036 nerve Anatomy 0.000 abstract description 7
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- 238000004458 analytical method Methods 0.000 description 14
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- 230000008569 process Effects 0.000 description 6
- 230000004064 dysfunction Effects 0.000 description 5
- 206010061296 Motor dysfunction Diseases 0.000 description 4
- 238000010030 laminating Methods 0.000 description 4
- 230000000694 effects Effects 0.000 description 3
- 230000001537 neural effect Effects 0.000 description 3
- 208000012661 Dyskinesia Diseases 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 230000013011 mating Effects 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- 206010017577 Gait disturbance Diseases 0.000 description 1
- 208000016285 Movement disease Diseases 0.000 description 1
- 239000004677 Nylon Substances 0.000 description 1
- 241001272996 Polyphylla fullo Species 0.000 description 1
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- 238000010586 diagram Methods 0.000 description 1
- 230000007831 electrophysiology Effects 0.000 description 1
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Abstract
The utility model discloses an experimental animals fixing device and animal experiment system, this experimental animals fixing device includes the fixing base, a supporting seat, the fixed subassembly of head and the fixed subassembly of shank, the fixing base can be installed on running gear, the one end of supporting seat is connected on the fixing base, the other end is used for installing outside experimental apparatus, the fixed subassembly of head is connected on the supporting seat, the fixed subassembly of head can be connected the head with fixed experimental animals with experimental animals's neck ring, the fixed subassembly of shank is connected on the fixing base, be equipped with the shank fixed orifices on the fixed subassembly of shank, the shank fixed orifices is used for restricting experimental animals's shank. This experimental animals fixing device can fix the animal that the hind limb has serious motor function obstacle to can fix outside other experimental apparatus, make things convenient for going on of nerve regulation and control experiment.
Description
Technical Field
The utility model relates to an animal experiment research technical field especially relates to an experimental animals fixing device and animal experiment system.
Background
Gait behavior characterization of animals is an important part of the research and treatment process of movement diseases. Transmissions such as animal walkers or crawlers are well suited for this study. The current technology is to limit the animal in the closed space on the track directly, and detect the animal's movement behavior and gait characteristics by adjusting the speed of the track. When the legs of the animals have serious motor dysfunction, the animals have difficulty in walking and even standing, and the motor behavior and gait behavior characteristics of the animals cannot be detected by using the existing technical means.
In addition, when gait analysis experiment process is carried out, the nerve regulation experiment is often carried out in a matched manner, and the existing gait experiment device cannot well meet the experiment requirement of carrying out the nerve regulation experiment and the gait analysis experiment at the same time.
SUMMERY OF THE UTILITY MODEL
A first object of the utility model is to provide an experimental animals fixing device, this experimental animals fixing device can be fixed to the animal that the hind limb has serious motor function obstacle to can fix outside other experimental apparatus, conveniently carry out the animal experiment.
A second object of the present invention is to provide an experimental system, which can facilitate the exercise experiment of animals with serious motor dysfunction on hind limbs.
For realizing the above technical effect, the technical scheme of the utility model as follows:
the utility model discloses an experimental animal fixing device, which comprises a fixing seat, wherein the fixing seat can be arranged on a walking device; one end of the supporting seat is connected to the fixing seat, and the other end of the supporting seat is used for mounting an external experimental device; the head fixing component is connected to the supporting seat and can be connected with a neck ring of the experimental animal to fix the head of the experimental animal; the leg fixing assembly is connected to the fixing seat, leg fixing holes are formed in the leg fixing assembly and used for limiting legs of the experimental animal.
In some embodiments, the head fixation assembly comprises: the mounting piece is provided with a mounting groove; the matching piece is detachably arranged in the mounting groove; the mounting piece and the fitting piece are provided with matching holes, and the neck ring is connected with the head fixing component through a connecting piece arranged in the matching holes in a penetrating mode.
In some specific embodiments, the mount comprises: one end of the connecting part is connected with the supporting seat; the U-shaped portion, U-shaped portion with the other end of connecting portion links to each other, all be equipped with on two branches of relative setting of U-shaped portion the mounting groove.
In some embodiments, the depth of the mounting groove is greater than the thickness of the mating member.
In some embodiments, the holder comprises: the seat body is formed into a U shape; the fixed legs are multiple, one end of each fixed leg is connected with the base, and the other end of each fixed leg can be detachably connected with the walking device.
In some embodiments, the experimental animal fixing device further comprises a blocking member disposed at the open end of the seat body.
In some embodiments, the support seat comprises: one end of the supporting part is connected with the fixed seat, and the supporting part is used for installing the head fixing device; the installation department, the installation department is located head fixing device top, the one end of installation department with the supporting part links to each other, and the other end is used for the installation outside experimental apparatus.
In some embodiments, the leg fixing device comprises a bandage, two ends of the bandage are connected with two opposite side walls of the fixing base, and two leg fixing holes are arranged on the bandage at intervals.
In some optional embodiments, both ends of the bandage are provided with velcro.
The utility model also discloses an animal experiment system includes running gear, pressure sensor, outside experimental apparatus and in the foregoing experimental animal fixing device, experimental animal fixing device establishes on the running gear, outside experimental apparatus installs on the experimental animal fixing device, the pressure sensor laminating is in experimental animal's sole and/or the pressure sensor laminating is in running gear's surface.
The utility model discloses experimental animals fixing device owing to have the fixed subassembly of head and the fixed subassembly of shank, can fix the experimental animals that the shank has serious movement dysfunction on running gear to realized carrying out the function of motion gesture analysis to the experimental animals that have the movement dysfunction. In addition, because can install outside experimental apparatus on the supporting seat for the fixing device of this embodiment animal can carry out motion gesture analysis experiment and other experiments simultaneously, has satisfied user's user demand betterly.
The animal experiment system of this embodiment because the animal fixing device of specific foretell, realized that the upper part of the body of laboratory animal is fixed and external experimental facilities's is fixed to can also carry out other experiments such as waiting when having realized carrying out the function of movement gesture analysis to the laboratory animal that has the dyskinesia, better satisfy user's user demand.
Additional aspects and advantages of the invention will be set forth in part in the description which follows and, in part, will be obvious from the description, or may be learned by practice of the invention.
Drawings
Fig. 1 is a schematic structural view of the experimental animal fixing device according to the embodiment of the present invention.
Fig. 2 is a schematic structural diagram of a head fixing assembly according to an embodiment of the present invention.
Fig. 3 is a schematic structural view of a leg fixing assembly according to an embodiment of the present invention.
Reference numerals:
1. a fixed seat; 11. a base body; 12. a fixed leg;
2. a supporting seat; 21. a support portion; 22. an installation part;
3. a head fixation assembly; 31. a mounting member; 311. a connecting portion; 3111. mounting grooves; 312. a U-shaped portion; 32. a mating member;
4. a leg securing assembly; 41. a leg fixing hole;
5. a barrier.
Detailed Description
In order to make the technical problem solved by the present invention, the technical solution adopted by the present invention and the technical effect achieved by the present invention clearer, the technical solution of the present invention will be further explained by combining the drawings and by means of the specific implementation manner.
In the description of the present invention, it is to be understood that the terms "center", "longitudinal", "lateral", "length", "width", "thickness", "upper", "lower", "front", "rear", "left", "right", "vertical", "horizontal", "top", "bottom", "inner", "outer", "clockwise", "counterclockwise", "axial", "radial", "circumferential", and the like, indicate the orientation or positional relationship based on the orientation or positional relationship shown in the drawings, and are only for convenience of description and simplicity of description, and do not indicate or imply that the device or element referred to must have a particular orientation, be constructed and operated in a particular orientation, and therefore, should not be construed as limiting the present invention.
Furthermore, features defined as "first" and "second" may explicitly or implicitly include one or more of the features for distinguishing between descriptive features, non-sequential, non-trivial and non-trivial. In the description of the present invention, "a plurality" means two or more unless otherwise specified.
In the description of the present invention, it is to be noted that, unless otherwise explicitly specified or limited, the terms "mounted," "connected," and "connected" are to be construed broadly, and may be, for example, fixedly connected, detachably connected, or integrally connected; can be mechanically or electrically connected; they may be connected directly or indirectly through intervening media, or they may be interconnected between two elements. The specific meaning of the above terms in the present invention can be understood in specific cases to those skilled in the art.
The experimental animal fixing device according to an embodiment of the present invention will be described with reference to fig. 1 to 3.
As shown in fig. 1-3, the utility model discloses experimental animals fixing device of embodiment includes fixing base 1, a supporting seat 2, head fixed component 3 and shank fixed component 4, fixing base 1 can be installed on running gear, the one end of supporting seat 2 is connected on fixing base 1, the other end is used for installing outside experimental apparatus, head fixed component 3 is connected on supporting seat 2, head fixed component 3 can be connected with experimental animals's neck ring with fixed experimental animals's head, shank fixed component 4 is connected on fixing base 1, be equipped with shank fixed orifices 41 on shank fixed component 4, shank fixed orifices 41 is used for restricting experimental animals's shank.
It can be understood that, in the actual use process, the fixing base 1 is installed on the walking device, then the hind limb of the experimental animal passes through the leg fixing hole 41 so that the experimental animal can be stably held on the leg fixing component 4, and then the neck ring of the experimental animal is fixed on the head fixing component 3, so that the experimental animal can be fixed on the experimental animal fixing device. Because the existence of the head fixing component 3 and the leg fixing component 4, even if serious movement dysfunction appears in the legs of the experimental animal, the experimental animal can be ensured to stably carry out the movement posture analysis experiment on the walking device, thereby better meeting the experiment requirement. Meanwhile, the supporting seat 2 can support the head fixing component 3 and can be used for fixing an external experimental device, and in the actual experimental process, the external experimental device can select experimental devices such as electrophysiology and optogenetics according to actual needs, so that the neural regulation and control experiment is synchronously performed in the process of performing the motion posture analysis experiment.
The utility model discloses experimental animals fixing device owing to have fixed subassembly 3 of head and the fixed subassembly 4 of shank, can fix the experimental animals that the shank has serious movement dysfunction on running gear to the function of moving the gesture analysis is carried out to the experimental animals that have the movement dysfunction has been realized. In addition, because can install outside experimental apparatus on the supporting seat 2 for the fixing device of this embodiment animal can carry out motion attitude analysis experiment and neural regulation and control experiment simultaneously, has satisfied user's user demand betterly.
It should be additionally noted that, in this embodiment, the walking device may be a treadmill, or may be a walking track, or may be a conveyor belt structure, that is, the walking device only needs to be able to realize that the laboratory animal can move relative to the walking device, and the walking device can adjust the movement speed relative to the laboratory animal.
In some embodiments, as shown in fig. 2, the head fixing assembly 3 includes a mounting member 31 and a fitting member 32, the mounting member 31 is provided with a mounting groove 3111, and the fitting member 32 is detachably mounted in the mounting groove 3111. The mounting member 31 and the fitting member 32 are provided with fitting holes, and the neck rings are connected to the head fixing assembly 3 through connecting members inserted into the fitting holes.
It will be appreciated that during the actual experiment, the volume of the experimental animals varies, so that the size of the neck ring of the experimental animals also varies. In this embodiment, since the mounting part 31 and the fitting piece 32 are both provided with the fitting holes, the fitting holes on the mounting part 31 or the fitting piece 32 can be matched according to actual needs when actually fixing the neck ring of the experimental animal, so that the head fixing component 3 of this embodiment can be well compatible with neck rings of different sizes. In addition, since the fitting member 32 is detachably mounted in the mounting groove 3111, when the size of the neck ring is changed greatly, the fitting member 32 can be replaced to adapt to the size change of the neck ring, so that the head fixing assembly 3 of the present embodiment can be compatible with more sizes of neck rings.
In some specific embodiments, as shown in fig. 2, the mounting member 31 includes a connecting portion 311 and a U-shaped portion 312, one end of the connecting portion 311 is connected to the supporting seat 2, the U-shaped portion 312 is connected to the other end of the connecting portion 311, and two opposite branches of the U-shaped portion 312 are respectively provided with a mounting groove 3111. It can be understood that, when the neck ring of the experimental animal is fixed on the mounting member 31, the mounting member 31 has the U-shaped portion 312, so that the head of the experimental animal is limited in the U-shaped portion 312 of the mounting member 31 to a certain extent, thereby avoiding the phenomenon that the head of the experimental animal moves too much to cause the nerve regulation experiment to be performed normally. It should be noted that, in this embodiment, the connecting portion 311 and the U-shaped portion 312 may be integrally formed, or two separate components may be connected by a connecting member such as a screw, a rivet, or a pin, or may be connected by a fastening structure such as a fixing post and a fixing hole.
In some embodiments, the depth of the mounting groove 3111 is greater than the thickness of the fitting 32. Therefore, the neck ring is fixed on the fitting piece 32, so that the neck ring can be well protected, and the phenomenon that the experimental animal is out of control due to damage caused by the exposed neck ring is avoided.
Of course, in other embodiments of the present invention, the head fixing device may be formed as a box body with both upper and lower ends open, instead of the U-shaped structure of the present embodiment.
In some embodiments, as shown in fig. 1, the fixing base 1 includes a base 11 and a fixing leg 12. The seat body 11 is formed into a U shape, the fixed legs 12 are multiple, one end of each fixed leg 12 is connected with the seat body 11, and the other end can be detachably connected with the walking device. It can be understood that the base body 11 is U-shaped and can limit the experimental animal in the base body 11 of the base body 11, thereby avoiding the phenomenon that the experimental animal falls from the walking device and ensuring the stability of the motion attitude analysis experiment.
In some embodiments, the experimental animal fixing device further comprises a blocking member 5, and the blocking member 5 is disposed at the open end of the seat body 11. Therefore, the movement space of the experimental animal is further limited, and the dynamic attitude analysis experiment can be stably carried out.
Advantageously, the blocking member 5 is removably attached to the body 11 by means of screws or the like. Therefore, the experimental animal can be conveniently taken out of the animal fixing device of the embodiment after the experiment is finished.
In addition, it should be additionally noted that the fixing base 1 can be directly formed into a circular ring shape or a square ring shape, and can also play a role in limiting the activity space of the experimental animal.
In some embodiments, as shown in fig. 1, the supporting seat 2 includes a supporting portion 21 and a mounting portion 22, one end of the supporting portion 21 is connected to the fixing seat 1, the supporting portion 21 is used for mounting the head fixing device, the mounting portion 22 is located above the head fixing device, one end of the mounting portion 22 is connected to the supporting portion 21, and the other end is used for mounting the external experimental device. Therefore, the support portion 21 can ensure the connection stability of the support base 2 and the fixing base 1 and the connection stability of the head fixing device. And the installation part 22 can ensure the installation stability of the external experimental device, thereby ensuring that the nerve regulation experiment can be stably carried out.
Advantageously, the head fixing device is detachably connected to the supporting portion 21 through a connecting piece, so that the position of the head fixing device can be adjusted according to the height of the experimental animal in the actual experiment process, and the compatibility of the experimental animals with different heights is realized.
In some embodiments, as shown in fig. 3, the leg fixing device comprises a bandage, two ends of which are connected to two opposite side walls of the fixing base 1, and two leg fixing holes 41 are formed in the bandage at intervals. From this, adopt the bandage as shank fixing device, can simplify shank fixing device's cost on the one hand to reduce whole experimental animals fixing device's manufacturing cost, on the other hand can ensure that experimental animals's shank is fixed and the motion travelling comfort, ensures that motion gesture analysis experiment can go on steadily.
In some alternative embodiments, both ends of the bandage are provided with velcro. From this, can fix the bandage on fixing base 1 through the separable fastening fabric comparatively conveniently to can guarantee the stability of bandage, thereby ensure the stable support to the laboratory animal.
Example (b):
the experimental animal holding device according to an embodiment of the present invention will be described with reference to fig. 1 to 3.
As shown in fig. 1-3, the experimental animal fixing device of the embodiment of the present invention includes a fixing base 1, a supporting base 2, a head fixing component 3, a leg fixing component 4, and a blocking component 5.
The fixing base 1 comprises a base body 11 and fixing legs 12. The seat body 11 is formed into a U shape, the fixed legs 12 are multiple, one end of each fixed leg 12 is connected with the seat body 11, and the other end can be detachably connected with the walking device. The blocking member 5 is disposed at the open end of the seat body 11. The supporting seat 2 comprises a supporting portion 21 and an installation portion 22, one end of the supporting portion 21 is connected with the fixing seat 1, the supporting portion 21 is used for installing a head fixing device, the installation portion 22 is located above the head fixing device, one end of the installation portion 22 is connected with the supporting portion 21, and the other end of the installation portion is used for installing an external experiment device. The head fixing component 3 comprises a mounting part 31 and two fitting parts 32, the mounting part 31 comprises a connecting part 311 and a U-shaped part 312, one end of the connecting part 311 is connected with the supporting seat 2, the U-shaped part 312 is connected with the other end of the connecting part 311, and two opposite branches of the U-shaped part 312 are provided with mounting grooves 3111. The two fitting members 32 are fitted in the mounting groove 3111. The U-shaped portion 312 of the mounting member 31 and the fitting member 32 are provided with fitting holes, and the neck ring is connected to the head fixing assembly 3 by a connecting member inserted into the fitting holes. The leg fixing device comprises a bandage, two ends of the bandage are connected with two oppositely arranged side walls of the seat body 11, and nylon buckles are arranged at two ends of the bandage. The bandage is provided with two leg fixing holes 41 which are arranged at intervals, and the leg fixing holes 41 are used for limiting the legs of the experimental animal.
The advantages of the animal fixation device of the present application are as follows:
firstly, the method comprises the following steps: the experimental animal with serious motor dysfunction on hind limbs can be supported, so that the motor function of the experimental animal with motor dysfunction is detected;
secondly, the method comprises the following steps: external experimental equipment can be arranged on the supporting seat 2, so that various nerve regulation experiments can be performed while function detection is performed on experimental animals;
thirdly, the method comprises the following steps: the head fixing component 3 can realize neck rings with various sizes, realizes the compatibility of the animal fixing device to experimental animals with different volumes, and expands the application range of the animal fixing device;
fourthly: the bandage is adopted as the leg fixing device, so that the leg fixing and the movement comfort of the experimental animal can be ensured, and the movement posture analysis experiment can be stably carried out.
The utility model also discloses an animal experiment system, this animal experiment system include running gear, pressure sensor, outside experimental apparatus and the experimental animals fixing device in the former, and experimental animals fixing device establishes on running gear, and outside experimental apparatus installs on experimental animals fixing device, and the pressure sensor laminating is on experimental animals's sole portion and/or the surface of pressure sensor laminating at running gear. It can be understood that, the utility model discloses an animal experiment system carries out the in-process at the experiment, can be fixed with experimental animals's upper part of the body, through the height-adjusting for on the shank can be more natural contact running gear's the track, make the animal can accomplish the walking. And the characteristics of the animal's motor behavior and gait behavior can be recorded and analyzed by means of the pressure sensors. Under the condition that has kept the simple operation nature, can detect low limbs motion function, the head is half fixed state to experimental animals fixing device can install multiple outside experimental facilities, provides probably for the use of multiple neurobiology technique.
It should be added to say that, in the embodiment of the present invention, the external experimental device may be a light nerve regulation experimental device, an injection device, or other experimental devices, and may be specifically selected according to actual needs.
Advantageously, the animal experiment system of the embodiment further comprises a camera, so that the motion posture of the experimental animal can be recorded, and the experiment precision is improved.
The animal experiment system of this embodiment, because the animal fixing device of specific foretell, realized that experimental animals's upper part of the body is fixed and external experimental facilities's is fixed to can also carry out the neural regulation and control experiment when having realized carrying out the function of motion gesture analysis to experimental animals that have the dyskinesia, better satisfy user's user demand.
In the description herein, references to the description of "some embodiments," "other embodiments," etc., mean that a particular feature, structure, material, or characteristic described in connection with the embodiment or example is included in at least one embodiment or example of the invention. In this specification, the schematic representations of the terms used above do not necessarily refer to the same embodiment or example. Furthermore, the particular features, structures, materials, or characteristics described may be combined in any suitable manner in any one or more embodiments or examples.
The above description is only for the preferred embodiment of the present invention, and for those skilled in the art, there are variations on the detailed description and the application scope according to the idea of the present invention, and the content of the description should not be construed as a limitation to the present invention.
Claims (10)
1. A laboratory animal holding apparatus, comprising:
the walking device comprises a fixed seat (1), wherein the fixed seat (1) can be arranged on the walking device;
one end of the supporting seat (2) is connected to the fixed seat (1), and the other end of the supporting seat (2) is used for mounting an external experimental device;
the head fixing component (3) is connected to the supporting seat (2), and the head fixing component (3) can be connected with a neck ring of an experimental animal to fix the head of the experimental animal;
the leg fixing component (4), the leg fixing component (4) is connected on the fixing base (1), leg fixing holes (41) are formed in the leg fixing component (4), and the leg fixing holes (41) are used for limiting the legs of the experimental animal.
2. Laboratory animal holding device according to claim 1, characterized in that the head holding assembly (3) comprises:
the mounting piece (31), the mounting piece (31) is provided with a mounting groove (3111);
the fitting piece (32), the said fitting piece (32) is mounted in the said mounting groove (3111) removably; wherein:
the mounting piece (31) and the fitting piece (32) are provided with fitting holes, and the neck ring is connected with the head fixing component (3) through a connecting piece arranged in the fitting holes in a penetrating mode.
3. Laboratory animal holding device according to claim 2, characterized in that the mounting (31) comprises:
the connecting part (311), one end of the connecting part (311) is connected with the supporting seat (2);
the U-shaped portion (312), U-shaped portion (312) with the other end of connecting portion (311) links to each other, all be equipped with on two branches of relative setting of U-shaped portion (312) mounting groove (3111).
4. Laboratory animal holding device according to claim 2, characterized in that the depth of the mounting groove is greater than the thickness of the fitting piece (32).
5. Laboratory animal holding device according to claim 1, characterized in that the holder (1) comprises:
the seat body (11), the seat body (11) is formed into a U shape;
the walking device comprises a plurality of fixed legs (12), wherein the fixed legs (12) are multiple, one end of each fixed leg (12) is connected with the seat body (11), and the other end of each fixed leg can be detachably connected with the walking device.
6. Laboratory animal holding device according to claim 5, characterized in that it further comprises a blocking element (5), said blocking element (5) being provided at the open end of said seat (11).
7. Laboratory animal holding device according to claim 1, characterized in that the support base (2) comprises:
one end of the supporting part (21) is connected with the fixed seat (1), and the supporting part (21) is used for installing the head fixing component;
installation department (22), installation department (22) are located the fixed subassembly top of head, the one end of installation department (22) with supporting part (21) link to each other, and the other end is used for the installation outside experimental apparatus.
8. The laboratory animal fixing device according to claim 1, characterized in that the leg fixing assembly (4) comprises a bandage, two ends of which are connected to two opposite side walls of the fixing base (1), and two leg fixing holes (41) are formed in the bandage at intervals.
9. The laboratory animal holding apparatus according to claim 8, wherein both ends of said bandage are provided with velcro.
10. An animal testing system, comprising: the experimental animal fixing device comprises a walking device, a pressure sensor, an external experimental device and the experimental animal fixing device as claimed in any one of claims 1 to 9, wherein the experimental animal fixing device is arranged on the walking device, the external experimental device is installed on the experimental animal fixing device, and the pressure sensor is attached to the bottom of a foot of an experimental animal and/or the pressure sensor is attached to the surface of the walking device.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202021748824.4U CN213607139U (en) | 2020-08-20 | 2020-08-20 | Experimental animal fixing device and animal experiment system |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202021748824.4U CN213607139U (en) | 2020-08-20 | 2020-08-20 | Experimental animal fixing device and animal experiment system |
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| CN213607139U true CN213607139U (en) | 2021-07-06 |
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