CN114403861A - Animal posture experiment system - Google Patents
Animal posture experiment system Download PDFInfo
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- CN114403861A CN114403861A CN202210184189.9A CN202210184189A CN114403861A CN 114403861 A CN114403861 A CN 114403861A CN 202210184189 A CN202210184189 A CN 202210184189A CN 114403861 A CN114403861 A CN 114403861A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/103—Detecting, measuring or recording devices for testing the shape, pattern, colour, size or movement of the body or parts thereof, for diagnostic purposes
- A61B5/11—Measuring movement of the entire body or parts thereof, e.g. head or hand tremor, mobility of a limb
- A61B5/1116—Determining posture transitions
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
- A61B5/0077—Devices for viewing the surface of the body, e.g. camera, magnifying lens
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/103—Detecting, measuring or recording devices for testing the shape, pattern, colour, size or movement of the body or parts thereof, for diagnostic purposes
- A61B5/1036—Measuring load distribution, e.g. podologic studies
- A61B5/1038—Measuring plantar pressure during gait
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/103—Detecting, measuring or recording devices for testing the shape, pattern, colour, size or movement of the body or parts thereof, for diagnostic purposes
- A61B5/11—Measuring movement of the entire body or parts thereof, e.g. head or hand tremor, mobility of a limb
- A61B5/1126—Measuring movement of the entire body or parts thereof, e.g. head or hand tremor, mobility of a limb using a particular sensing technique
- A61B5/1128—Measuring movement of the entire body or parts thereof, e.g. head or hand tremor, mobility of a limb using a particular sensing technique using image analysis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/24—Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
- A61B5/316—Modalities, i.e. specific diagnostic methods
- A61B5/369—Electroencephalography [EEG]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B2503/00—Evaluating a particular growth phase or type of persons or animals
- A61B2503/40—Animals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B2503/00—Evaluating a particular growth phase or type of persons or animals
- A61B2503/42—Evaluating a particular growth phase or type of persons or animals for laboratory research
Abstract
An animal posture experiment system is provided, comprising: experimental apparatus, experimental apparatus includes: the system comprises a gait experiment module, a maze training module and an open field experiment module, wherein any one of the gait experiment module, the maze training module and the open field experiment module is selected for experiment; the pressure monitoring device is used for acquiring the pressure information of the limb tail end of the animal to be tested; the image monitoring device is used for shooting the posture image information of the animal to be tested in the experimental device; the electrophysiological signal monitoring device is used for acquiring the electroencephalogram information of the animal to be tested and applying an electrical stimulation signal to the animal to be tested; and the processing device is used for acquiring the electroencephalogram information, the pressure information and the posture image information. According to the animal posture experiment system provided by the disclosure, the gait experiment module, the maze training module and the open field experiment module are arranged to acquire the pressure information, the posture image information and the electroencephalogram information of the animal to be tested, so that the comprehensive analysis in multiple aspects can be realized, and the accuracy of the analysis result is improved.
Description
Technical Field
The disclosure relates to the field of biotechnology, in particular to an animal posture experiment system.
Background
The animal posture refers to the change relationship of limbs in space and time in the advancing process of animals, is an important analysis method in animal behavioural and cognitive psychological researches, and has important significance for the diagnosis and research of various physiological and psychological diseases.
However, the current animal posture experiment device has a single analysis mode, so that the accuracy of an analysis result is low.
Disclosure of Invention
It would be advantageous to provide a mechanism that alleviates, mitigates or even eliminates one or more of the above-mentioned problems.
According to an embodiment of the present disclosure, there is provided an animal posture experiment system, including: an experimental apparatus, comprising: the system comprises a gait experiment module, a maze training module and an open field experiment module, wherein any one of the gait experiment module, the maze training module and the open field experiment module is selected for experiment; the gait experiment module comprises a running machine for enabling an animal to be tested to walk, the maze training module comprises a plurality of channels for enabling the animal to be tested to pass through and at least one plug board inserted into the channels, each plug board can move relative to the channels to change the communication relation of the channels, and the open field experiment module comprises an experiment platform for enabling the animal to be tested to move freely; the pressure monitoring device comprises a plurality of pressure sensors arranged on the treadmill, and the pressure sensors are used for acquiring the pressure information of the limb tail ends of the animals to be tested; the image monitoring device comprises a camera assembly arranged on the experimental device, and the camera assembly is used for shooting the attitude image information of the animal to be tested in the experimental device; the electrophysiological signal monitoring device comprises an electrophysiological signal collector which is arranged on the head of an animal to be tested and is used for collecting electroencephalogram information of the animal to be tested and applying an electrical stimulation signal to the animal to be tested to control the motion direction of the animal to be tested; and the processing device is in wireless communication connection with the electrophysiological signal collector to acquire the electroencephalogram information or send a command for generating an electrical stimulation signal to the electrophysiological signal collector, and is also in communication connection with the plurality of pressure sensors and the camera shooting assembly to acquire the pressure information and the attitude image information respectively.
According to the animal posture experiment system provided by the embodiment of the disclosure, the gait experiment module, the maze training module and the open field experiment module are arranged to acquire the pressure information, the posture image information and the electroencephalogram information of the animal to be tested, so that comprehensive analysis in multiple aspects can be realized, and the accuracy of an analysis result can be improved.
These and other aspects of the disclosure will be apparent from and elucidated with reference to the embodiments described hereinafter.
Drawings
Further details, features and advantages of the disclosure are disclosed in the following description of exemplary embodiments, taken in conjunction with the accompanying drawings, in which:
fig. 1 is a block diagram illustrating a structure of an animal pose experiment system according to an exemplary embodiment;
FIG. 2 is a block diagram illustrating the structure of an experimental apparatus according to an example embodiment;
FIG. 3 is a block diagram illustrating a gait experiment module according to an example embodiment;
FIG. 4 is a block diagram illustrating a rotarod experimental module according to an exemplary embodiment;
fig. 5 is a top view illustrating an animal pose experimental system according to an example embodiment.
Detailed Description
It will be understood that, although the terms first, second, third, etc. may be used herein to describe various elements, components, regions, layers and/or sections, these elements, components, regions, layers and/or sections should not be limited by these terms. These terms are only used to distinguish one element, component, region, layer or section from another element, component, region, layer or section. Thus, a first element, component, region, layer or section discussed below could be termed a second element, component, region, layer or section without departing from the teachings of the present disclosure.
Spatially relative terms such as "below …," "below …," "lower," "below …," "above …," "upper," and the like may be used herein for ease of description to describe one element or feature's relationship to another element(s) or feature(s) as illustrated in the figures. It will be understood that these spatially relative terms are intended to encompass different orientations of the device in use or operation in addition to the orientation depicted in the figures. For example, if the device in the figures is turned over, elements described as "below" or "beneath" or "under" other elements or features would then be oriented "above" the other elements or features. Thus, the example terms "below …" and "below …" may encompass both an orientation above … and below …. Terms such as "before …" or "before …" and "after …" or "next to" may similarly be used, for example, to indicate the order in which light passes through the elements. The devices may be otherwise oriented (rotated 90 degrees or at other orientations) and the spatially relative descriptors used herein interpreted accordingly. In addition, it will also be understood that when a layer is referred to as being "between" two layers, it can be the only layer between the two layers, or one or more intervening layers may also be present.
The terminology used herein is for the purpose of describing particular embodiments only and is not intended to be limiting of the disclosure. As used herein, the singular forms "a", "an" and "the" are intended to include the plural forms as well, unless the context clearly indicates otherwise. It will be further understood that the terms "comprises" and/or "comprising," when used in this specification, specify the presence of stated features, integers, steps, operations, elements, and/or components, but do not preclude the presence or addition of one or more other features, integers, steps, operations, elements, components, and/or groups thereof. As used herein, the term "and/or" includes any and all combinations of one or more of the associated listed items, and the phrase "at least one of a and B" refers to a alone, B alone, or both a and B.
It will be understood that when an element or layer is referred to as being "on," "connected to," "coupled to" or "adjacent to" another element or layer, it can be directly on, connected to, coupled to or adjacent to the other element or layer or intervening elements or layers may be present. In contrast, when an element is referred to as being "directly on," "directly connected to," "directly coupled to," or "directly adjacent to" another element or layer, there are no intervening elements or layers present. However, neither "on … nor" directly on … "should be construed as requiring that one layer completely cover an underlying layer in any event.
Embodiments of the present disclosure are described herein with reference to schematic illustrations (and intermediate structures) of idealized embodiments of the present disclosure. As such, variations from the shapes of the illustrations as a result, for example, of manufacturing techniques and/or tolerances, are to be expected. Thus, embodiments of the present disclosure should not be construed as limited to the particular shapes of regions illustrated herein but are to include deviations in shapes that result, for example, from manufacturing. Thus, the regions illustrated in the figures are schematic in nature and their shapes are not intended to illustrate the actual shape of a region of a device and are not intended to limit the scope of the present disclosure.
Unless otherwise defined, all terms (including technical and scientific terms) used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this disclosure belongs. It will be further understood that terms, such as those defined in commonly used dictionaries, should be interpreted as having a meaning that is consistent with their meaning in the context of the relevant art and/or the present specification and will not be interpreted in an idealized or overly formal sense unless expressly so defined herein.
In the related art, the footprint of an animal to be tested, such as a mouse, is usually detected by an ink method, and the gait of the animal is analyzed based on the detected footprint. However, the method is relatively simple in analysis, and the accuracy of the analysis result is easily poor.
In order to solve the above problems, the embodiment of the present disclosure provides an animal posture experiment system, so as to obtain pressure information, posture image information, and electroencephalogram information of an animal to be tested by setting a gait experiment module, a maze training module, and an open field experiment module, which can realize comprehensive analysis in many aspects, thereby improving accuracy of an analysis result.
The embodiments of the present disclosure will be described in detail below with reference to the accompanying drawings. Fig. 1 is a block diagram illustrating a structure of an animal posture experiment system according to an exemplary embodiment, fig. 2 is a block diagram illustrating a structure of an experiment apparatus according to an exemplary embodiment, and fig. 3 is a block diagram illustrating a gait experiment module according to an exemplary embodiment.
Referring to fig. 1 to fig. 3, the present embodiment provides an animal posture experiment system 10, including: the experimental device 100, the pressure monitoring device 200, the image monitoring device 300, the electrophysiological signal monitoring device 400, and the processing device 500.
The experimental apparatus 100 includes: gait experiment module 110, maze training module 120 and open field experiment module 130. Any of the gait experiment module 110, the maze training module 120 and the open field experiment module 130 are selected for the experiment.
The gait experiment module 110 includes a running machine 111 for the animal 20 to be experimented to walk. The maze training module 120 includes a plurality of passages for allowing the passage of the animal 20 to be tested, and at least one insert plate inserted into the plurality of passages, each of the at least one insert plate being movable relative to the plurality of passages to change the communication relationship of the plurality of passages.
The open field experiment module 130 includes an experiment platform for freely moving the animal 20 to be tested.
The pressure monitoring device 200 includes a plurality of pressure sensors 210 provided to the treadmill 111. The plurality of pressure sensors 210 are used to collect pressure information of the extremity of the animal 20 to be tested.
The image monitoring apparatus 300 includes a camera module 310 provided in the experimental apparatus 100. The camera assembly 310 is used for shooting the posture image information of the animal 20 to be tested in the experimental device 100.
The electrophysiological signal monitoring device 400 comprises an electrophysiological signal collector 410 for being arranged on the head of the animal 20 to be tested. The electrophysiological signal collector 410 is used for collecting electroencephalogram information of the animal 20 to be tested and for applying an electrical stimulation signal to the animal 20 to be tested to control the direction of movement of the animal 20 to be tested.
The processing device 500 is in wireless communication connection with the electrophysiological signal collector 410 to obtain electroencephalogram information or send an instruction for generating an electrical stimulation signal to the electrophysiological signal collector 410. The processing device 500 is also communicatively coupled to the plurality of pressure sensors 210 and the camera assembly 310 to acquire pressure information and pose image information, respectively.
It is understood that the experimental device 100 may have a mounting platform on which different modules may be selectively placed during different experiments. For example, the gait experiment module 110 can be placed on the mounting platform when performing a gait experiment. In conducting a maze experiment, maze training module 120 may be placed on the mounting platform. When performing an open field experiment, the open field experiment module 130 may be placed on a mounting platform.
Referring to fig. 3, the treadmill 111 of the gait experiment module 110 can be a common structure capable of running. When the animal 20 to be tested is placed on the running machine 111, the running machine 111 moves, and the animal 20 to be tested is given the motion stimulus to move on the running machine 111.
In some embodiments, the gait experiment module 110 includes a transparent first casing 112, and the treadmill 111 is disposed in the first casing 112. The treadmill 111 includes a pulley set 1111 and a transmission belt 1112 connected to the pulley set 1111, the transmission belt 1112 is used for the animal 20 to be tested to walk, and the plurality of pressure sensors 210 are arranged in an array on the transmission belt 1112.
Wherein, the first box 112 can facilitate observing the movement of the animal 20 to be tested inside. The pressure sensors 210 can be uniformly distributed on the transmission belt 1112, so that the animal 20 to be tested can acquire the pressure information of the extremity thereof during the movement.
In one particular embodiment, belt 1112 is a transparent structure. The camera assembly 310 includes at least one first camera 311 disposed in the first box 112, and the at least one first camera 311 is disposed under the treadmill 111.
It is understood that the first camera 311 may be a common structure capable of capturing images or videos. The first camera 311 can be located in the gait experiment module 110, and since the transmission belt 1112 is of a transparent structure, the first camera 311 can directly shoot the landing point of the animal 20 to be tested from the bottom, and the obtained posture image information is more direct.
In some embodiments, the animal 20 to be tested may be moved into the gait experiment module 110 by a transfer cage. In the gait experiment module 110, one end of the first box 112 may be provided with a transfer cage interface, and the other end may be provided with a food induction box. The food-inducing box may be stored with food so that both ends of the moving direction of the treadmill 111 may be the transfer cage interface and the food-inducing box, respectively, so that the animal 20 to be tested may be encouraged to run along the treadmill 111.
In the gait experiment, the animal 20 to be tested may be positioned on the running machine 111, so that the animal 20 to be tested runs on the running machine 111, and then the processing device 500 may obtain the pressure information, that is, the stress condition of the extremity of the animal 20 to be tested, through the pressure sensor 210. Through the stress analysis, the gait parameters can be calculated, and then the gait pressure analysis is carried out. Meanwhile, the camera assembly 310 can also synchronously acquire the posture image information of the animal 20 to be tested on the treadmill 111 through a synchronous interface. The processing device 500 may acquire pose image information and perform gait cycle analysis. In addition, the processing device 500 can also acquire the electroencephalogram information of the animal 20 to be tested through the electrophysiological signal collector 410, so as to perform electroencephalogram cognitive analysis, and perform behavior analysis on the animal 20 to be tested by integrating gait pressure analysis, gait cycle analysis and electroencephalogram cognitive analysis.
It is understood that the gait pressure analysis can analyze the step size of the animal 20 to be tested, the force of the left foot and the right foot on the ground, and the like, and the gait cycle analysis can analyze the number of steps of walking per second, the span of the left foot and the right foot, and the like. The electroencephalogram cognitive analysis can analyze the activity degree of the brain moving region of the animal 20 to be tested, and the like. In addition, a comparison experiment group can be arranged, namely, the normal animal 20 and the sick animal 20 to be tested are respectively analyzed, and the accuracy of the experiment result is further improved.
Through the above analysis, the animal 20 to be tested can be comprehensively analyzed, and compared with gait analysis by an ink method in the related art, the gait analysis method has high accuracy of the analysis result. For animal gait analysis, parameters can be extracted based on a single footprint, including but not limited to: maximum foot contact time phase, maximum foot contact area, foot contact pressure, foot print width, foot contact time, proportion of the same paw contact time to the total time, walking cycle and stride. The relationship parameters may also be extracted based on different limbs, including but not limited to: number of steps per unit time, pace sequence, stride width (difference between forelimb and hindlimb).
In the labyrinth experiment, the insert plate can enable a plurality of channels to present different communication states, so that different labyrinths are presented. For example, the maze may be T-shaped, Y-shaped, cross-shaped, and the like. In addition, the maze training module 120 may further include a transparent box, the channel and the insertion board may be disposed in the box, and the camera assembly 310 may be located outside the box, and acquire the posture image information of the animal 20 to be tested inside the box through the transparent box.
In some embodiments, the camera assembly 310 may include a plurality of third cameras 313 disposed above the experimental device 100. The third camera 313 may be a common structure capable of taking an image or a movie. The third camera 313 may be used to photograph the animal 20 to be tested inside the experimental apparatus 100 from above. It is understood that, for the maze experiment, in order not to interfere with the behavior of the animal 20 to be tested, the side of each channel may be an opaque structure, and the top thereof may be a transparent structure, so as to facilitate the third camera 313 to photograph the animal 20 to be tested from the top.
When a maze experiment is performed, the animal 20 to be tested can be positioned in a maze formed by a plurality of channels, then the image pickup assembly 310 is used for shooting the attitude image information of the animal 20 to be tested, and the electrophysiological information of the animal 20 to be tested is monitored by the electrophysiological signal collector 410. The processing device 500 may acquire the posture image information and the electroencephalogram information, so as to analyze the posture and the electroencephalogram cognition of the animal 20 to be tested, and further perform the behavioural and electrophysiological analysis when the path of the animal 20 to be tested is selected and moved.
In addition, the electrophysiological signal collector 410 is further provided with an electrode, and the processing device 500 can also apply an electrical stimulation signal to the animal 20 to be tested through the electrode, so as to control the moving direction of the animal 20 to be tested in the maze, for example, turning left or turning right. And stimulation feedback analysis can be performed by observing whether the moving direction of the animal 20 to be tested is consistent with the applied electrical stimulation signal.
In some embodiments, the plurality of third cameras 313 may be respectively disposed at corners above the experimental apparatus 100, so that the photographing field of view may cover the entire experimental apparatus 100.
Additionally, in some embodiments, each of the plurality of third cameras 313 includes an infrared camera. The infrared camera can provide an enhanced light source for the third camera 313 in the dark environment, so that the posture image information of the animal to be tested 20 can be shot in the dark environment, and the maze experiment can be favorably carried out in the dark environment.
The open field experiment module 130 can observe the characteristic that the animal 20 to be tested moves freely in the open field. In the open field experiment, the electroencephalogram information and the posture image information of the animal 20 to be tested are mainly acquired. The processing device 500 can obtain the posture image information and the electroencephalogram information through the camera assembly 310 and the electrophysiological signal collector 410, respectively, so as to analyze the posture and the electroencephalogram cognition of the animal 20 to be tested.
It can be understood that, in the related art, there is a lack of complete open field experimental apparatus, and observation of animal behavioural and electrophysiological activities of the animal 20 to be tested cannot be performed. The animal posture experiment system 10 is incorporated into open field experiment module 130 to this embodiment, in epilepsy molding experiment, Parkinson's behavior experiment, the experiment of awaking of anesthesia, all can carry out the accurate observation of multi-angle. When the above experiment is performed, the processing device 500 is provided with various data processing functional modules, and the data filtering effect can be changed according to the actual collection situation. In the epilepsy modeling experiment, the processing device 500 uses a built-in epilepsy state judging module, can automatically judge the brain waveform of an epileptic seizure interval, applies electrical stimulation to an experimental animal according to a preset scheme, carries out epilepsy inhibition processing, and realizes the epilepsy regulation and control closed-loop control function. In the parkinson behavior experiment, the processing device 500 may automatically determine abnormal discharge of the parkinson brain region by using a built-in parkinson state determination module. In the experiment of recovering from anesthesia, the processing apparatus 500 uses the module for monitoring the depth of anesthesia, and can automatically perform the evaluation of the depth of anesthesia in real time.
It can be understood that, in the present embodiment, by setting the gait experiment module 110, the maze training module 120 and the open field experiment module 130, the pressure information, the posture image information and the electroencephalogram information of the animal 20 to be tested in the gait experiment can be acquired, and the posture image information and the electroencephalogram information in the maze experiment and the open field experiment can be acquired, so that the comprehensive analysis of multiple experiments and multiple indexes can be realized, and the accuracy of the analysis result can be improved.
In addition, the processing device 500 is connected with the electrophysiological signal collector 410 in a wireless communication manner, and compared with a wired connection manner in the related art, the interference to the animal 20 to be tested is smaller, so that the experiment is closer to the free movement of the animal 20 to be tested. The camera assembly 310 can ensure that the details of the movement of the limbs can be accurately captured no matter how the animal 20 to be tested is oriented, so that feature extraction can be conveniently carried out in the subsequent experimental analysis.
FIG. 4 is a block diagram illustrating a rotarod experimental module according to an example embodiment. Referring to FIG. 4, the experimental apparatus 100 further includes a rotating rod experimental module 140 for selecting experiments. The rotarod assay module 140 includes: a rotatable rotating rod 141 and a plurality of grids 142 arranged in parallel and at intervals along the axial direction of the rotating rod 141, and a part of the rotating rod 141 between two adjacent grids 142 is used for placing the animal 20 to be tested.
It is understood that the rotating rod 141 may be horizontally disposed, and a driving structure such as a driving motor may be connected thereto, so that the rotating rod 141 may be controlled to rotate.
The rotating rod 141 may be fixed with a grating 142, and the grating 142 may have a plate-like structure. The area of the grill 142 may be larger than the cross-sectional area of the rotating rod 141 to provide a separation function. Further, the grid 142 can divide the rotating rod 141 into a plurality of stations, and each station can be provided with one animal 20 to be tested, so that a plurality of groups of experiments can be performed simultaneously, and the experimental efficiency and the accuracy of the experimental result are improved.
The rotarod test is mainly used to evaluate the motor ability of the animal 20 to be tested, diseases or damages of the central nervous system, and the influence of drugs on motor coordination function and fatigue. During the experiment, the rotating rod 141 can rotate at a certain speed, and the animal 20 to be tested stands on the rotating rod 141 and needs to move in the opposite direction to maintain the position. If lactic acid in the body of the animal 20 to be tested cannot be removed and converted in time during the exercise, the animal will quickly become fatigued and fall off the rotating rod 141. In addition, the rotating rod experiment module 140 may have a timing function and a rotation speed adjusting function, so that the rotation time and the rotation speed of the rotating rod 141 may be controlled.
The camera component 310 can shoot the posture image information of the animal 20 to be tested, the electrophysiological signal collector 410 can monitor the electroencephalogram information of the animal 20 to be tested, and the processing device 500 can acquire the posture image information and the electroencephalogram information, so that the posture and electroencephalogram cognition of the animal 20 to be tested can be analyzed.
Fig. 5 is a top view illustrating an animal pose experimental system according to an example embodiment. Referring to fig. 5, in some embodiments, the camera assembly 310 may further include a plurality of second cameras 312 disposed around the experimental device 100.
It is understood that the second camera 312 may be a common structure capable of capturing images or images, and may be located outside the experimental apparatus 100. A plurality of second cameras 312 may be disposed around experimental device 100. Taking the cubic experimental apparatus 100 as an example, the plurality of second cameras 312 may be disposed around the circumference of the experimental apparatus 100. The height of the second camera 312 may be lower than that of the third camera 313 so that it can photograph the posture image information of the animal 20 to be tested from the substantially front side of the experimental apparatus 100.
In addition, since the second camera 312 is disposed outside the experimental apparatus 100, it can be applied to a plurality of experiments and photograph posture image information, thereby simplifying the structure of each experimental module. For example, the second camera 312 may be applied to gait experiments together with the first camera 311, or it may be applied to open field experiments alone, or the second camera 312 may be applied to rolling bar experiments alone.
In some embodiments, the animal pose testing system 10 further comprises a support 600 disposed around the testing apparatus 100, wherein a plurality of mounting positions 610 are disposed on the support 600 in an array, and each mounting position 610 is used for mounting any one of the plurality of second cameras 312.
It is understood that the rack 600 may enclose an experimental space, and the experimental space may have an experimental platform therein, and the experimental apparatus 100 may be disposed on the experimental platform in the experimental space. The stand 600 may be constructed of a frame structure or a panel structure. A plurality of mounting locations 610 may be arranged in an array on the stand 600, and each second camera 312 may be mounted to any one of the mounting locations 610. Through the mounted position who selects second camera 312, can be according to the demand adjustment second camera 312's of experiment module position to make the scope of making a video recording can cover the home range of waiting to test animal 20, and the gesture image information that obtains is more accurate.
The detachable mounting between each mounting location 610 and second camera 312 may be varied. For example, the mounting position 610 may be used for being fixedly connected with the second camera 312 in a snap-fit manner, for example, the mounting position 610 may be a mounting hole, and the second camera 312 may be provided with a hook, and the hook may be fixedly connected to the mounting hole in the snap-fit manner. Alternatively, the mounting position 610 may be fixed to the second camera 312 by a screw thread, for example, the mounting position 610 may include a screw hole, and a screw may be inserted through the second camera 312 and screwed into the screw hole.
Of course, the third camera 313 may be disposed on the bracket 600. The third camera 313 can also be mounted on the support 600 through the mounting position 610 on the support 600, so that the position of the third camera 313 can also be adaptively adjusted. The connection between the third camera 313 and the installation site 610 may refer to the connection between the second camera 313 and the installation site 610, and is not described in detail.
The third camera 313 may be used for a maze experiment to acquire pose image information of the animal 20 to be tested. Of course, it can also be used in other experiments to assist in obtaining relevant information.
While the disclosure has been illustrated and described in detail in the drawings and foregoing description, such illustration and description are to be considered illustrative and exemplary and not restrictive; the present disclosure is not limited to the disclosed embodiments. Variations to the disclosed embodiments can be understood and effected by those skilled in the art in practicing the claimed subject matter, from a study of the drawings, the disclosure, and the appended claims. In the claims, the word "comprising" does not exclude other elements or steps not listed, the indefinite article "a" or "an" does not exclude a plurality, and the term "a plurality" means two or more. The mere fact that certain measures are recited in mutually different dependent claims does not indicate that a combination of these measures cannot be used to advantage.
Description of reference numerals:
10: an animal posture experiment system; 100: an experimental device;
110: a gait experiment module; 111: a treadmill;
1111: a pulley block; 1112: a transmission belt;
112: a first case; 120: a maze training module;
130: an open field experiment module; 140: a rotating rod experiment module;
141: rotating the rod; 142: a grid;
200: a pressure monitoring device; 210: a pressure sensor;
300: an image monitoring device; 310: a camera assembly;
311: a first camera; 312: a second camera;
313: a third camera; 400: an electrophysiological signal monitoring device;
410: an electrophysiological signal collector; 500: a processing device;
600: a support; 610: an installation position;
20: and (5) animals to be tested.
Claims (10)
1. An animal pose experiment system, comprising:
an experimental apparatus, comprising: the system comprises a gait experiment module, a maze training module and an open field experiment module, wherein any one of the gait experiment module, the maze training module and the open field experiment module is selected for experiment; wherein the content of the first and second substances,
the gait experiment module comprises a running machine for the walking of the animal to be tested,
the maze training module comprises a plurality of channels for enabling the animals to pass and at least one plug board inserted in the channels, each plug board can move relative to the channels to change the communication relation of the channels,
the open field experiment module comprises an experiment platform which is used for enabling the animal to be tested to freely move;
the pressure monitoring device comprises a plurality of pressure sensors arranged on the treadmill, and the pressure sensors are used for acquiring the pressure information of the limb tail ends of the animals to be tested;
the image monitoring device comprises a camera component arranged on the experimental device, and the camera component is used for shooting the attitude image information of an animal to be tested in the experimental device;
the electrophysiological signal monitoring device comprises an electrophysiological signal collector which is arranged on the head of the animal to be tested and is used for collecting electroencephalogram information of the animal to be tested and applying an electrical stimulation signal to the animal to be tested so as to control the movement direction of the animal to be tested; and
the processing device is in wireless communication connection with the electrophysiological signal collector to acquire the electroencephalogram information or send a command for generating an electrical stimulation signal to the electrophysiological signal collector, and is also in communication connection with the plurality of pressure sensors and the camera shooting assembly to acquire the pressure information and the attitude image information respectively.
2. The animal pose experimental system of claim 1, wherein,
the gait experiment module comprises a transparent first box body, the running machine is arranged in the first box body and comprises a belt wheel set and a transmission belt connected with the belt wheel set, the transmission belt is used for supplying the walking of the animal to be tested, and the pressure sensor arrays are arranged on the transmission belt.
3. The animal pose experimental system of claim 2, wherein,
the transmission belt is of a transparent structure, the camera shooting assembly comprises at least one first camera arranged in the first box body, and the at least one first camera is arranged below the running machine.
4. The animal pose experimental system of any one of claims 1-3, wherein said experimental apparatus further comprises a rotarod experimental module for selecting for experiments;
the rotating rod experiment module comprises: rotatable commentaries on classics stick and along a plurality of grids that the axis direction of commentaries on classics stick is parallel and the interval sets up, the part between two adjacent grids the commentaries on classics stick is used for placing the animal of waiting to experimental.
5. The animal pose experimental system of any one of claims 1 to 3, wherein said camera assembly comprises a plurality of second cameras disposed around said experimental device.
6. The animal pose experimental system of claim 5, further comprising: the bracket is arranged around the experimental device, a plurality of mounting positions arranged in an array are arranged on the bracket, and each mounting position is used for mounting any one of the second cameras.
7. The animal pose experiment system of claim 6, wherein said mounting location is configured to engage and fixedly connect with said second camera.
8. The animal pose experimental system of any one of claims 1 to 3, wherein said camera assembly comprises a plurality of third cameras disposed above said experimental device.
9. The animal pose experiment system of claim 8, wherein said plurality of third cameras are respectively disposed at corners above said experimental device.
10. The animal pose experiment system of claim 9, wherein each of said plurality of third cameras comprises an infrared camera.
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| CN116171885A (en) * | 2022-09-07 | 2023-05-30 | 燕山大学 | Closed loop ultrasonic stimulation system and method for free activity mouse behavior state dependence |
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