CN213553884U - Chitosan oral ulcer patch based on temperature-sensitive microcapsule structure - Google Patents
Chitosan oral ulcer patch based on temperature-sensitive microcapsule structure Download PDFInfo
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- CN213553884U CN213553884U CN202022454502.5U CN202022454502U CN213553884U CN 213553884 U CN213553884 U CN 213553884U CN 202022454502 U CN202022454502 U CN 202022454502U CN 213553884 U CN213553884 U CN 213553884U
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- Prior art keywords
- temperature
- traditional chinese
- chinese medicine
- chitosan
- sensitive
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- 239000003094 microcapsule Substances 0.000 title claims abstract description 26
- 229920001661 Chitosan Polymers 0.000 title claims abstract description 20
- 208000007117 Oral Ulcer Diseases 0.000 title claims description 14
- 208000002399 aphthous stomatitis Diseases 0.000 title claims description 14
- 239000003814 drug Substances 0.000 claims abstract description 56
- 239000000341 volatile oil Substances 0.000 claims abstract description 7
- 239000010410 layer Substances 0.000 claims description 34
- 239000012790 adhesive layer Substances 0.000 claims description 4
- 230000000694 effects Effects 0.000 abstract description 9
- 230000008859 change Effects 0.000 abstract description 7
- 230000003902 lesion Effects 0.000 abstract description 7
- 208000025865 Ulcer Diseases 0.000 abstract description 5
- 231100000397 ulcer Toxicity 0.000 abstract description 5
- 210000002200 mouth mucosa Anatomy 0.000 abstract description 3
- 230000000638 stimulation Effects 0.000 abstract description 3
- 238000013270 controlled release Methods 0.000 abstract description 2
- 230000002035 prolonged effect Effects 0.000 abstract description 2
- 229940079593 drug Drugs 0.000 description 13
- 239000000463 material Substances 0.000 description 6
- 210000000214 mouth Anatomy 0.000 description 4
- 206010052428 Wound Diseases 0.000 description 3
- 208000027418 Wounds and injury Diseases 0.000 description 3
- 238000000034 method Methods 0.000 description 3
- 230000008569 process Effects 0.000 description 3
- 241000894006 Bacteria Species 0.000 description 2
- 230000009471 action Effects 0.000 description 2
- 230000007547 defect Effects 0.000 description 2
- 238000005538 encapsulation Methods 0.000 description 2
- 210000001519 tissue Anatomy 0.000 description 2
- 208000003322 Coinfection Diseases 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 239000004372 Polyvinyl alcohol Substances 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 239000002390 adhesive tape Substances 0.000 description 1
- 230000000172 allergic effect Effects 0.000 description 1
- 208000010668 atopic eczema Diseases 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000003467 diminishing effect Effects 0.000 description 1
- 238000007598 dipping method Methods 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- 238000012377 drug delivery Methods 0.000 description 1
- 230000000857 drug effect Effects 0.000 description 1
- 230000035876 healing Effects 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- 239000000155 melt Substances 0.000 description 1
- 210000004877 mucosa Anatomy 0.000 description 1
- 230000000149 penetrating effect Effects 0.000 description 1
- 229920002451 polyvinyl alcohol Polymers 0.000 description 1
- 230000008929 regeneration Effects 0.000 description 1
- 238000011069 regeneration method Methods 0.000 description 1
- 230000008439 repair process Effects 0.000 description 1
- 210000003296 saliva Anatomy 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 238000005507 spraying Methods 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 230000009967 tasteless effect Effects 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 229940126680 traditional chinese medicines Drugs 0.000 description 1
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Abstract
In order to solve the problem that the treatment effect of the dental ulcer patch is poor, the utility model provides a chitosan dental ulcer patch based on a temperature-sensitive microcapsule structure, which mainly comprises a pasting layer consisting of chitosan and a traditional Chinese medicine layer connected to the surface of the pasting layer, wherein the traditional Chinese medicine layer consists of temperature-sensitive microcapsules wrapped with traditional Chinese medicine volatile oil, the pasting layer adopts chitosan to isolate the lesion surface from the external environment, reduce the stimulation of food friction, temperature change and the like and protect the lesion surface; the traditional Chinese medicine layer adopts temperature-sensitive microcapsules to wrap traditional Chinese medicine volatile oil, the temperature-sensitive microcapsules wrap traditional Chinese medicine effective components, the loss of the effective components can be prevented at normal temperature, the temperature-sensitive microcapsules generate phase change when reaching a certain temperature, the temperature-sensitive controlled release effective components enable oral mucosa tissues to absorb the medicine, the release speed and the dosage of the medicine are controlled through the change of the oral temperature, the time of the medicine acting on affected surfaces is prolonged, the bioavailability of the medicine is greatly improved, and therefore the optimal curative effect is achieved.
Description
Technical Field
The utility model relates to an oral ulcer paster technical field, in particular to chitosan oral ulcer paster based on temperature sensitive microcapsule structure.
Background
The patch for treating oral ulcer on the market has good effect and can treat ulcer to a certain extent, but the patch on the market at present has the following defects:
1. the hygiene is not effectively guaranteed. The traditional patch is applied to the affected part by dipping a little saliva on the finger and sticking the patch. Some bacteria are inevitably contacted in the process, and secondary infection on the wound is very likely to be caused, so that the wound is not cured for a long time;
2. the thickness of the product on the market is extremely large, discomfort is brought to the oral cavity, and activities such as speaking, eating and the like are greatly influenced;
3. the action time is short. The traditional Chinese medicine patch at present needs to consume a large amount of traditional Chinese medicines, and the processing process is complex. A part of active ingredients volatilize in the processing process, which greatly increases the cost of the patch and reduces the drug effect, and the drug playing time is shortened due to the reasons of insecure sticking, poor buccal effect and the like when the drug plays a role;
4. the main mode for treating oral ulcer in the market is spraying, so due to the limitation of dosage forms, the medicine for treating oral ulcer melts in the mouth, so that the impact on taste is caused, and the daily life is influenced;
5. the retention time of the spray, the buccal medicine and the like on the lesion part is short, the use rate and the action rate of the medicine are greatly reduced, and the medicine penetrates into the oral tissue to play the effects of diminishing inflammation, relieving pain and the like.
SUMMERY OF THE UTILITY MODEL
In order to solve the problem, the utility model provides a chitosan oral ulcer paster based on temperature sensitive microcapsule structure, the technical scheme of adoption as follows:
a chitosan oral ulcer patch based on a temperature-sensitive microcapsule structure is characterized by mainly comprising a sticking layer consisting of chitosan and a traditional Chinese medicine layer connected to the surface of the sticking layer, wherein the traditional Chinese medicine layer consists of temperature-sensitive microcapsules wrapped with traditional Chinese medicine volatile oil.
Preferably, a groove is formed in the inner surface of the sticking layer, the traditional Chinese medicine layer is located in the groove, and the inner surface of the traditional Chinese medicine layer is flush with the inner surface of the sticking layer.
Preferably, the inner surface of the traditional Chinese medicine layer is flush with the inner surface of the sticking layer.
The beneficial effects of the utility model reside in that:
1. the traditional Chinese medicine layer adopts temperature-sensitive microcapsules to wrap traditional Chinese medicine volatile oil, the temperature-sensitive microcapsules are used to wrap effective components of the traditional Chinese medicine, the effective components can be prevented from losing at normal temperature, and the patch is colorless and tasteless basically and has small volatilization loss of the effective components;
2. the temperature-sensitive microcapsule wrapped with the Chinese medicinal volatile oil has phase change when reaching a certain temperature, and the temperature-sensitive controlled release effective components enable oral mucosa tissues to absorb the medicament, and the release speed and dosage of the medicament are controlled through the change of the oral temperature, so that the time of the medicament acting on the affected surface is prolonged, the bioavailability of the medicament is greatly improved, and the optimal curative effect is exerted;
3. the adhesive layer adopts chitosan, so that the lesion surface is isolated from the external environment, the stimulation such as food friction and temperature change is reduced, the lesion surface is protected, and meanwhile, the traditional Chinese medicine layer is wrapped in the groove of the adhesive layer, so that the medicine is prevented from overflowing to a certain extent, and the maximum utilization rate of the medicine is realized.
Drawings
FIG. 1 is a schematic view of the structure of the present invention
FIG. 2 is a sectional view taken along line A-A
Wherein, 1-sticking layer, 2-Chinese medicine layer.
Detailed Description
Exemplary embodiments of the present disclosure will be described in detail below with reference to fig. 1-2. While exemplary embodiments of the present disclosure are shown in the drawings, it should be understood that the present disclosure may be embodied in various forms and should not be limited to the embodiments set forth herein. Rather, these embodiments are provided so that this disclosure will be thorough and complete, and will fully convey the scope of the disclosure to those skilled in the art.
In the description of the present invention, it is to be understood that the terms "longitudinal", "lateral", "up", "down", "front", "back", "left", "right", "vertical", "horizontal", "top", "bottom", "inner", "outer", and the like indicate orientations or positional relationships based on those shown in the drawings, and are only for convenience of description of the present invention, and do not indicate or imply that the device or element so referred to must have a particular orientation, be constructed and operated in a particular orientation, and therefore, should not be construed as limiting the present invention.
The chitosan dental ulcer patch based on the temperature-sensitive microcapsule structure as shown in fig. 1-2 mainly comprises a patch layer 1 and a traditional Chinese medicine layer 2, wherein the patch layer 1 is mainly made of chitosan materials, the chitosan materials have good effects of resisting bacteria and repairing wounds, can clear away heat and toxic materials, and can be used for astringing and relieving pain, and as a patch material, the chitosan dental ulcer patch can be stably pasted on an affected part, is not easy to displace and can prevent adhesion; the traditional Chinese medicine layer 2 mainly comprises temperature-sensitive microcapsules wrapped with traditional Chinese medicine volatile oil, a circular groove is arranged in the middle of the inner surface of the sticking layer 1, the traditional Chinese medicine layer 2 is pasted in the groove on the inner surface of the sticking layer 1 in a gel-like manner, and the inner surface of the traditional Chinese medicine layer 2 is flush with the inner surface of the sticking layer 1.
When the multifunctional adhesive tape is used, the patch is integrally adhered to an oral cavity affected part through the adhering layer 1, the traditional Chinese medicine layer is attached to the surface of the affected part, the adhering layer 1 isolates a lesion surface from the external environment, stimulation such as food friction and temperature change is reduced, the lesion surface is protected, the chitosan material has good adhesion, is easy to adhere to the oral cavity mucosa and is not easy to generate allergic symptoms, the chitosan has good biocompatibility, flexibility and film forming property, and is used as an adhering material, so that the defects that polyvinyl alcohol is not easy to coat and adhere and is not smooth in adhering surface are avoided, regeneration, repair and healing of the oral ulcer surface are facilitated, and an auxiliary treatment effect is achieved.
The temperature-sensitive microcapsule is used as a carrier of the drug to form a drug encapsulation layer, when the patch is pasted on the oral mucosa, the temperature-sensitive microcapsule is used as a temperature control switch to control and release the drug encapsulated in the temperature-sensitive microcapsule under the environment of the oral temperature, and then drug molecules enter the skin in a tissue penetrating drug delivery mode to play a role in drug treatment; meanwhile, the temperature-sensitive microcapsule can fix drug molecules in the microcapsule, volatilization loss does not occur at normal temperature, the smell of the drug is reduced, the drug encapsulation layer can release the drug under the oral temperature environment, zero-order release and constant absorption of the drug are facilitated, and the microcapsule is light and thin in structure, small in volume, lighter in overall structure and convenient to carry compared with the traditional oral ulcer drug.
The above description is only a preferred embodiment of the present invention, and it should be noted that: for those skilled in the art, without departing from the principle of the present invention, several improvements can be made, and these improvements should also be regarded as the protection scope of the present invention.
Claims (3)
1. A chitosan oral ulcer patch based on a temperature-sensitive microcapsule structure is characterized by mainly comprising a sticking layer consisting of chitosan and a traditional Chinese medicine layer connected to the surface of the sticking layer, wherein the traditional Chinese medicine layer consists of temperature-sensitive microcapsules wrapped with traditional Chinese medicine volatile oil.
2. The chitosan oral ulcer patch based on the temperature-sensitive microcapsule structure as claimed in claim 1, wherein a groove is formed on the inner surface of the adhesive layer, and the traditional Chinese medicine layer is located in the groove.
3. The chitosan oral ulcer patch based on temperature-sensitive microcapsule structure as claimed in claim 2, wherein the inner surface of the traditional Chinese medicine layer is flush with the inner surface of the adhesive layer.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202022454502.5U CN213553884U (en) | 2020-10-30 | 2020-10-30 | Chitosan oral ulcer patch based on temperature-sensitive microcapsule structure |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202022454502.5U CN213553884U (en) | 2020-10-30 | 2020-10-30 | Chitosan oral ulcer patch based on temperature-sensitive microcapsule structure |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN213553884U true CN213553884U (en) | 2021-06-29 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202022454502.5U Expired - Fee Related CN213553884U (en) | 2020-10-30 | 2020-10-30 | Chitosan oral ulcer patch based on temperature-sensitive microcapsule structure |
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| CN (1) | CN213553884U (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115192763A (en) * | 2022-07-08 | 2022-10-18 | 重庆科技学院 | Multifunctional temperature-regulating wound dressing and preparation method and application thereof |
-
2020
- 2020-10-30 CN CN202022454502.5U patent/CN213553884U/en not_active Expired - Fee Related
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115192763A (en) * | 2022-07-08 | 2022-10-18 | 重庆科技学院 | Multifunctional temperature-regulating wound dressing and preparation method and application thereof |
| CN115192763B (en) * | 2022-07-08 | 2023-12-12 | 重庆科技学院 | Multifunctional temperature-regulating wound dressing and preparation method and application thereof |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| CB03 | Change of inventor or designer information | ||
| CB03 | Change of inventor or designer information |
Inventor after: Pang Mengran Inventor after: Du Yongle Inventor after: Chen Bin Inventor after: Jin Shiyao Inventor after: Li Xintong Inventor after: Wu Yannan Inventor after: Zhao Wenying Inventor after: Luo Zixin Inventor before: Chen Bin Inventor before: Jin Shiyao Inventor before: Li Xintong Inventor before: Wu Yannan Inventor before: Zhao Wenying Inventor before: Luo Zixin Inventor before: Hou Lin Inventor before: Pang Guowei |
|
| CF01 | Termination of patent right due to non-payment of annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20210629 |