CN213475996U - Enzyme decomposition accelerating device in heparin sodium production process - Google Patents
Enzyme decomposition accelerating device in heparin sodium production process Download PDFInfo
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- CN213475996U CN213475996U CN202022042432.2U CN202022042432U CN213475996U CN 213475996 U CN213475996 U CN 213475996U CN 202022042432 U CN202022042432 U CN 202022042432U CN 213475996 U CN213475996 U CN 213475996U
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- tank body
- enzymolysis
- enzymolysis tank
- heparin sodium
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Abstract
The utility model discloses an accelerating enzyme decomposition device in the production process of heparin sodium, which comprises an enzymolysis tank body, wherein a stirring shaft is vertically arranged in the enzymolysis tank body, the upper end of the stirring shaft is transversely provided with stirring blades, the middle part of the stirring shaft is vertically provided with helical blades, the top part of the stirring shaft is connected with the output end of a speed reduction motor, the two sides of the top part of the enzymolysis tank body are respectively provided with a raw material inlet and an enzymolysis agent inlet, the outer side wall of the enzymolysis tank body is provided with a heating jacket, and the bottom; the utility model discloses a cooperation between helical blade and the stirring vane can make the material take place to flow in the enzymolysis tank body more easily, and the raw materials is difficult to the deposit in enzymolysis tank body bottom, has accelerateed the enzymolysis process, has improved enzymolysis efficiency.
Description
Technical Field
The utility model relates to a heparin sodium production technical field specifically indicates an enzyme decomposition device accelerates in heparin sodium production process.
Background
Heparin sodium (Heparin sodium) can interfere with many links of the blood coagulation process and has the anticoagulation effect in vivo and in vitro; at present, heparin sodium is generally through steps such as raw materials processing, enzymolysis extraction, ion exchange absorption and refining, at the enzymolysis in-process, need constantly stir and the heating process to the internal solution of enzymolysis tank, and the agitating unit who uses at present all stirs in the single direction, and the raw materials deposits easily in enzymolysis tank body bottom, leads to the enzymolysis insufficient, slow, and enzymolysis inefficiency finally influences the yield of heparin sodium.
Disclosure of Invention
An object of the utility model is to overcome above-mentioned not enough, provide an enzyme decomposition device accelerates in the heparin sodium production process, the enzymolysis process accelerates, improves enzymolysis efficiency.
The utility model discloses a solve above-mentioned technical problem, the technical scheme who adopts is: the utility model provides an enzyme decomposition device accelerates in heparin sodium production process, includes the enzymolysis tank body, the vertical (mixing) shaft that is equipped with of the internal portion of enzymolysis tank, the (mixing) shaft upper end transversely is equipped with stirring vane, the vertical helical blade that is equipped with in (mixing) shaft middle part, (mixing) shaft top is connected with the gear motor output, and enzymolysis tank body top both sides are equipped with raw materials import and enzymolysis agent import respectively, are equipped with on the outer lateral wall of the enzymolysis tank body and add the cover, and enzymolysis tank body bottom is equipped.
Preferably, an ultrasonic generator is arranged on one side in the enzymolysis tank body.
Preferably, the heating jacket is a steam heating jacket structure, the bottom of the heating jacket is provided with a steam inlet, the top of the heating jacket is provided with a steam outlet, and the steam inlet and the steam outlet are respectively connected with an outlet and an inlet of the electric heating steam generator.
More preferably, the other outlet of the electric heating steam generator is also connected with one end of a disinfection tube, and the other end of the disinfection tube extends into the enzymolysis tank body.
Preferably, gear motor passes through the frame and is fixed in enzymolysis tank body top central zone, enzymolysis tank body bottom is fixed in ground through the support frame.
Preferably, the top of the enzymolysis tank body is also provided with a pH regulator inlet.
Preferably, the bottom of the enzymolysis tank body is of a conical structure.
The utility model has the advantages that: the utility model discloses a cooperation between helical blade and the stirring vane can make the material take place to flow in the enzymolysis tank body more easily, and the raw materials is difficult to the deposit in enzymolysis tank body bottom, has accelerateed the enzymolysis process, has improved enzymolysis efficiency.
Drawings
FIG. 1 is a schematic structural diagram of an apparatus for accelerating enzymatic decomposition during heparin sodium production;
in the figure, an enzymolysis tank body 1, a stirring shaft 2, a stirring blade 3, a helical blade 4, a speed reduction motor 5, a raw material inlet 6, an enzymolysis agent inlet 7, a heating jacket 8, a steam inlet 8.1, a steam outlet 8.2, a discharge pipe 9, an ultrasonic generator 10, an electric heating steam generator 11, a disinfection pipe 12, a frame 13, a support frame 14 and a pH regulator inlet 15.
Detailed Description
The invention is described in further detail below with reference to the figures and the embodiments.
As shown in figure 1, an enzyme decomposition device accelerates in heparin sodium production process, including the enzymolysis tank body 1, the vertical (mixing) shaft 2 that is equipped with of the 1 inside of the enzymolysis tank body, the 2 upper ends of (mixing) shaft transversely are equipped with stirring vane 3, the vertical helical blade 4 that is equipped with in (mixing) shaft 2 middle part, the (mixing) shaft 2 top is connected with 5 output of gear motor, and 1 top both sides of the enzymolysis tank body are equipped with raw materials import 6 and enzymolysis agent import 7 respectively, are equipped with on the 1 lateral wall of the enzymolysis tank body and heat and press from both sides the cover 8, and 1. 4 vertical settings of helical blade, because its helical structure can mix the material and remove in vertical direction when it rotates, and stirring vane 3 transversely sets up, when it rotates, can stir the material and remove all around.
Preferably, an ultrasonic generator 10 is arranged on one side in the enzymolysis tank body 1. After the design, the ultrasonic wave generated by the ultrasonic generator 10 can accelerate the rupture of the cell wall of the raw material, the dissolution of the effective components and the enzymolysis process through the mechanical vibration, cavitation and thermal effect of the ultrasonic wave.
Preferably, the heating jacket 8 is a steam heating jacket structure, the bottom of the heating jacket is provided with a steam inlet 8.1, the top of the heating jacket is provided with a steam outlet 8.2, and the steam inlet 8.1 and the steam outlet 8.2 are respectively connected with an outlet and an inlet of the electric heating steam generator 11. Electric heating steam generator 11 produces hot steam to water and electricity heating, then enters into through steam inlet 8.1 and adds inside the jacket 8 to carry out the heating process to the enzymolysis tank body 1, in order to guarantee the required temperature of enzymolysis process, then partial steam and comdenstion water get back to in the electric heating steam generator 11 from steam outlet 8.2.
More preferably, the other outlet of the electric heating steam generator 11 is also connected with one end of a disinfection tube 12, and the other end of the disinfection tube 12 extends into the enzymolysis tank body 1. Through opening the valve on the disinfection pipe 12, the high-temperature steam that electric heating steam generator 11 produced enters into enzymolysis tank body 1 through disinfection pipe 12 in, can carry out the high-temperature sterilization process, just so need not external steam conduit in addition, directly utilizes electric heating steam generator 11 that heating jacket 8 corresponds to provide corresponding steam for entire system is retrencied.
Preferably, the speed reduction motor 5 is fixed in the center area of the top of the enzymolysis tank body 1 through a frame 13, and the bottom of the enzymolysis tank body 1 is fixed on the ground through a support frame 14.
Preferably, the top of the enzymolysis tank body 1 is also provided with a pH regulator inlet 15.
Preferably, the bottom of the enzymolysis tank body 1 is of a conical structure. After the design like this, when the material falls to the enzymolysis tank body 1 bottom, can slide to enzymolysis tank body 1 bottom central zone, and then slide to under helical blade 4, just so can be stirred by helical blade 4 again and upward movement, form the circulation.
The working principle of the embodiment is as follows:
firstly, raw materials (minced pork lungs in the embodiment) are added into an enzymolysis tank body 1 through a raw material inlet 6, an enzymolysis agent (minced fresh pancreatic pulp in the embodiment) is added into the enzymolysis tank body 1 through an enzymolysis agent inlet 7, a speed reduction motor 5 is started, which drives the stirring shaft 2 to rotate and further drives the stirring blade 3 and the helical blade 4 to rotate, in the embodiment, when the helical blade 4 rotates, the material is stirred to flow from bottom to top, the stirring blades 3 rotate transversely to continuously pull the materials outwards, the flowing direction of the whole materials is shown as the arrow direction in the enzymolysis tank body 1 in figure 1, a continuous circulating flowing process is formed, so that the materials are not easy to deposit at the bottom of the enzymolysis tank body 1, meanwhile, the stirring mode greatly enhances the mixing effect between the raw materials and the enzymolysis agent, and greatly improves the enzymolysis efficiency; in the stirring process, the electric heating steam generator 11 heats water and electricity to generate hot steam, then the hot steam enters the heating jacket 8 through the steam inlet 8.1, so that the enzymolysis tank body 1 is heated to ensure the temperature required by the enzymolysis process, and then part of the steam and condensed water return to the electric heating steam generator 11 from the steam outlet 8.2; adding alkali liquor into the enzymolysis tank body 1 through a pH regulator inlet 15, regulating the pH of the material in the enzymolysis tank body 1, keeping the pH =7.5-8 of the feed liquid, keeping the temperature of the feed liquid at 37-40 ℃, performing enzymolysis for 3-4 hours, heating to 47-50 ℃, maintaining the pH =8.0-8.5, adding a little enzymolysis agent as required, and continuing enzymolysis for 4-5 hours; after the enzymolysis process is completed, the valve on the discharge pipe 9 is opened, then the material is discharged to enter the next process, and finally, the high-temperature steam generated by the electric heating steam generator 11 enters the enzymolysis tank body 1 through the disinfection pipe 12 by opening the valve on the disinfection pipe 12, so that the high-temperature disinfection process can be carried out.
The above embodiments are merely preferred technical solutions of the present invention, and should not be considered as limitations of the present invention, and the features in the embodiments and the examples in the present application may be arbitrarily combined with each other without conflict. The protection scope of the present invention shall be defined by the claims and the technical solutions described in the claims, including the technical features of the equivalent alternatives as the protection scope. Namely, equivalent alterations and modifications within the scope of the invention are also within the scope of the invention.
Claims (7)
1. The utility model provides an enzyme decomposition device accelerates in heparin sodium production process, includes the enzymolysis tank body (1), its characterized in that: the inside vertical (mixing) shaft (2) that is equipped with of the enzymolysis tank body (1), stirring shaft (2) upper end transversely is equipped with stirring vane (3), the vertical helical blade (4) that is equipped with in (mixing) shaft (2) middle part, (mixing) shaft (2) top is connected with gear motor (5) output, and enzymolysis tank body (1) top both sides are equipped with raw materials import (6) and enzymolysis agent import (7) respectively, are equipped with on the enzymolysis tank body (1) lateral wall and add hot jacket (8), and the enzymolysis tank body (1) bottom is equipped with discharging pipe (9).
2. The device for accelerating enzymatic decomposition in the production process of heparin sodium according to claim 1, wherein: an ultrasonic generator (10) is arranged on one side in the enzymolysis tank body (1).
3. The device for accelerating enzymatic decomposition in the production process of heparin sodium according to claim 1, wherein: the heating jacket (8) is of a steam heating jacket structure, the bottom of the heating jacket is provided with a steam inlet (8.1), the top of the heating jacket is provided with a steam outlet (8.2), and the steam inlet (8.1) and the steam outlet (8.2) are respectively connected with an outlet and an inlet of the electric heating steam generator (11).
4. The device for accelerating enzymatic decomposition in the production process of heparin sodium according to claim 3, wherein: the other outlet of the electric heating steam generator (11) is also connected with one end of a disinfection tube (12), and the other end of the disinfection tube (12) extends into the enzymolysis tank body (1).
5. The device for accelerating enzymatic decomposition in the production process of heparin sodium according to claim 1, wherein: the speed reduction motor (5) is fixed in the center area of the top of the enzymolysis tank body (1) through a frame (13), and the bottom of the enzymolysis tank body (1) is fixed on the ground through a support frame (14).
6. The device for accelerating enzymatic decomposition in the production process of heparin sodium according to claim 1, wherein: the top of the enzymolysis tank body (1) is also provided with a pH regulator inlet (15).
7. The device for accelerating enzymatic decomposition in the production process of heparin sodium according to claim 1, wherein: the bottom of the enzymolysis tank body (1) is of a conical structure.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202022042432.2U CN213475996U (en) | 2020-09-17 | 2020-09-17 | Enzyme decomposition accelerating device in heparin sodium production process |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202022042432.2U CN213475996U (en) | 2020-09-17 | 2020-09-17 | Enzyme decomposition accelerating device in heparin sodium production process |
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| CN213475996U true CN213475996U (en) | 2021-06-18 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN202022042432.2U Active CN213475996U (en) | 2020-09-17 | 2020-09-17 | Enzyme decomposition accelerating device in heparin sodium production process |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114456927A (en) * | 2022-03-12 | 2022-05-10 | 江苏汉肽生物医药有限公司 | Enzymolysis furnace capable of keeping internal uniform sealing reaction and implementation method thereof |
| CN115197837A (en) * | 2022-09-15 | 2022-10-18 | 如东县新苗食品机械有限公司 | Enzymolysis equipment of edible starch suspension |
-
2020
- 2020-09-17 CN CN202022042432.2U patent/CN213475996U/en active Active
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114456927A (en) * | 2022-03-12 | 2022-05-10 | 江苏汉肽生物医药有限公司 | Enzymolysis furnace capable of keeping internal uniform sealing reaction and implementation method thereof |
| CN114456927B (en) * | 2022-03-12 | 2022-11-08 | 江苏汉肽生物医药有限公司 | Enzymolysis furnace capable of keeping uniform sealing reaction inside and implementation method thereof |
| CN115197837A (en) * | 2022-09-15 | 2022-10-18 | 如东县新苗食品机械有限公司 | Enzymolysis equipment of edible starch suspension |
| CN115197837B (en) * | 2022-09-15 | 2022-12-06 | 如东县新苗食品机械有限公司 | Enzymolysis equipment of edible starch suspension |
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